ROMO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.70510043
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.64583955
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.50655051
4ATP synthesis coupled proton transport (GO:0015986)7.50655051
5respiratory electron transport chain (GO:0022904)6.97822293
6electron transport chain (GO:0022900)6.79622985
7viral transcription (GO:0019083)6.77336007
8translational termination (GO:0006415)6.44465407
9ribosomal small subunit assembly (GO:0000028)6.40300803
10ribosomal small subunit biogenesis (GO:0042274)6.15298843
11DNA deamination (GO:0045006)6.05463732
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.05253840
13cotranslational protein targeting to membrane (GO:0006613)5.93764858
14protein targeting to ER (GO:0045047)5.91618703
15protein localization to endoplasmic reticulum (GO:0070972)5.63283788
16translational elongation (GO:0006414)5.62809339
17establishment of protein localization to endoplasmic reticulum (GO:0072599)5.59698743
18sequestering of actin monomers (GO:0042989)5.48132575
19chaperone-mediated protein transport (GO:0072321)5.45956028
20viral life cycle (GO:0019058)5.25361581
21protein complex biogenesis (GO:0070271)5.10014191
22cellular protein complex disassembly (GO:0043624)5.06490332
23mitochondrial respiratory chain complex assembly (GO:0033108)4.72326837
24protein neddylation (GO:0045116)4.68593162
25oxidative phosphorylation (GO:0006119)4.68551262
26translation (GO:0006412)4.63585554
27translational initiation (GO:0006413)4.63072785
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.62518448
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.59781602
30NADH dehydrogenase complex assembly (GO:0010257)4.59781602
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.59781602
32regulation of mitochondrial translation (GO:0070129)4.48955742
33ribosomal large subunit biogenesis (GO:0042273)4.40995439
34GTP biosynthetic process (GO:0006183)4.34608471
35proteasome assembly (GO:0043248)4.33537285
36protein complex disassembly (GO:0043241)4.27511820
37macromolecular complex disassembly (GO:0032984)4.12290720
38inner mitochondrial membrane organization (GO:0007007)4.08632963
39termination of RNA polymerase III transcription (GO:0006386)4.06624207
40transcription elongation from RNA polymerase III promoter (GO:0006385)4.06624207
41purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.05224975
42protein targeting to mitochondrion (GO:0006626)4.03850148
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.99378800
44cytochrome complex assembly (GO:0017004)3.98198691
45respiratory chain complex IV assembly (GO:0008535)3.97996979
46ATP biosynthetic process (GO:0006754)3.96829691
47protein targeting to membrane (GO:0006612)3.96237364
48maturation of SSU-rRNA (GO:0030490)3.91995987
49hydrogen ion transmembrane transport (GO:1902600)3.88111674
50establishment of protein localization to mitochondrion (GO:0072655)3.86227112
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.85639424
52UTP biosynthetic process (GO:0006228)3.71504986
53protein localization to mitochondrion (GO:0070585)3.68032270
54guanosine-containing compound biosynthetic process (GO:1901070)3.65861858
55ribonucleoside triphosphate biosynthetic process (GO:0009201)3.65521439
56regulation of oxidative phosphorylation (GO:0002082)3.65227482
57cellular component biogenesis (GO:0044085)3.56057567
58nucleobase-containing small molecule interconversion (GO:0015949)3.54935111
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.47087887
60pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.46166082
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40218482
62intracellular protein transmembrane import (GO:0044743)3.38217218
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.38196244
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.38196244
65iron-sulfur cluster assembly (GO:0016226)3.38011640
66metallo-sulfur cluster assembly (GO:0031163)3.38011640
67regulation of cellular amino acid metabolic process (GO:0006521)3.37577821
68cullin deneddylation (GO:0010388)3.34924193
69proton transport (GO:0015992)3.34885193
70peptidyl-histidine modification (GO:0018202)3.32361005
71UTP metabolic process (GO:0046051)3.32205245
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.32199422
73ribonucleoprotein complex biogenesis (GO:0022613)3.31919089
74CTP biosynthetic process (GO:0006241)3.31897330
75CTP metabolic process (GO:0046036)3.31897330
76RNA catabolic process (GO:0006401)3.31876448
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31749090
78rRNA modification (GO:0000154)3.31110858
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.30707948
80pseudouridine synthesis (GO:0001522)3.28753672
81aldehyde catabolic process (GO:0046185)3.28339335
82hydrogen transport (GO:0006818)3.27120680
83mitochondrial transport (GO:0006839)3.25215026
84nucleoside triphosphate biosynthetic process (GO:0009142)3.20770832
85nuclear-transcribed mRNA catabolic process (GO:0000956)3.17132037
86quinone biosynthetic process (GO:1901663)3.16102307
87ubiquinone biosynthetic process (GO:0006744)3.16102307
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15905304
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15384143
90protein deneddylation (GO:0000338)3.13700678
91antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.13223371
92DNA damage response, detection of DNA damage (GO:0042769)3.13190993
93regulation of cellular respiration (GO:0043457)3.09573005
947-methylguanosine mRNA capping (GO:0006370)3.09357045
95aerobic respiration (GO:0009060)3.08328885
96GDP-mannose metabolic process (GO:0019673)3.07583135
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06394118
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06394118
99rRNA processing (GO:0006364)3.05511030
100negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04859907
101negative regulation of ligase activity (GO:0051352)3.04859907
102protein-cofactor linkage (GO:0018065)3.04142027
103signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03831181
104signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03831181
105signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03831181
106RNA capping (GO:0036260)3.03577828
1077-methylguanosine RNA capping (GO:0009452)3.03577828
108spliceosomal snRNP assembly (GO:0000387)3.02348337
109mRNA catabolic process (GO:0006402)3.00532215
110anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98613366
111positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96914180
112purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.96291350
113purine nucleoside monophosphate biosynthetic process (GO:0009127)2.96291350
114L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95708714
115protein targeting (GO:0006605)2.95084942
116rRNA metabolic process (GO:0016072)2.94202359
117establishment of protein localization to membrane (GO:0090150)2.93768778
118water-soluble vitamin biosynthetic process (GO:0042364)2.93070861
119signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93039409
120chromatin remodeling at centromere (GO:0031055)2.91071962
121base-excision repair, AP site formation (GO:0006285)2.89688351
122signal transduction involved in DNA damage checkpoint (GO:0072422)2.87647486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.44551403
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.42716545
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.39278587
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.98503121
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.97896083
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.93713406
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.76060543
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.56620876
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.32555031
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.27179668
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.15759163
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.09918189
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99893358
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93893401
15CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.85301437
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.73472173
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66589465
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.59899441
19XRN2_22483619_ChIP-Seq_HELA_Human2.52311185
20DCP1A_22483619_ChIP-Seq_HELA_Human2.39648571
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.35984253
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.35023826
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34292717
24VDR_23849224_ChIP-Seq_CD4+_Human2.31543804
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28811257
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.27882852
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19484736
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.19000396
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18937376
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12548938
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03139156
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96332790
33TTF2_22483619_ChIP-Seq_HELA_Human1.96101189
34* GABP_19822575_ChIP-Seq_HepG2_Human1.85625218
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84937565
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83175443
37ELK1_19687146_ChIP-ChIP_HELA_Human1.82753887
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81964684
39ELK1_22589737_ChIP-Seq_MCF10A_Human1.80370682
40FOXP3_21729870_ChIP-Seq_TREG_Human1.78909662
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74634283
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73589931
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.73190468
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69763015
45CTCF_18555785_ChIP-Seq_MESCs_Mouse1.66915092
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65193640
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62990903
48BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.52367642
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52237445
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50210423
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.50145534
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40619349
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39064739
54ZNF274_21170338_ChIP-Seq_K562_Hela1.34674587
55VDR_22108803_ChIP-Seq_LS180_Human1.34219612
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29752907
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26276270
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25682291
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24985148
60HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24081269
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23848955
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23707972
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21307400
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20459199
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.20083445
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19973207
67CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18280926
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16580959
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15066792
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13271480
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12169510
72MYC_18940864_ChIP-ChIP_HL60_Human1.11726750
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11628854
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10365502
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09724035
76* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08049272
77* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08022589
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07634419
79TP53_22573176_ChIP-Seq_HFKS_Human1.05223037
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.04035223
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03768122
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03438563
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03329954
84CIITA_25753668_ChIP-Seq_RAJI_Human1.02890586
85* YY1_22570637_ChIP-Seq_MALME-3M_Human1.01717788
86EWS_26573619_Chip-Seq_HEK293_Human1.01390547
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01159267
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.01096525
89NANOG_16153702_ChIP-ChIP_HESCs_Human0.97181845
90FUS_26573619_Chip-Seq_HEK293_Human0.96383394
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96018223
92TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95405857
93BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94552850
94KDM5A_27292631_Chip-Seq_BREAST_Human0.94084242
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93737781
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91263374
97STAT1_20625510_ChIP-Seq_HELA_Human0.91197052
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90311219
99FOXP1_21924763_ChIP-Seq_HESCs_Human0.89748107
100OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89432579
101SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89293810
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87570219
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86215284
104NANOG_20526341_ChIP-Seq_ESCs_Human0.86102162
105ZNF263_19887448_ChIP-Seq_K562_Human0.86061935
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85479981
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85032393
108EZH2_22144423_ChIP-Seq_EOC_Human0.84623708
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84433864
110ERG_20517297_ChIP-Seq_VCAP_Human0.84342080
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84179512
112PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83800520
113RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83608976
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83568480
115* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83426087
116SPI1_23547873_ChIP-Seq_NB4_Human0.82963677
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82320774
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82237935
119CBX2_27304074_Chip-Seq_ESCs_Mouse0.82137327
120TP63_19390658_ChIP-ChIP_HaCaT_Human0.81905212
121BCL6_27268052_Chip-Seq_Bcells_Human0.81604828
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80645884
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79756987
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78306557
125HTT_18923047_ChIP-ChIP_STHdh_Human0.75929619
126E2F1_21310950_ChIP-Seq_MCF-7_Human0.75798884
127* AR_20517297_ChIP-Seq_VCAP_Human0.74864687
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.74417390
129FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73518994
130FOXA1_25329375_ChIP-Seq_VCAP_Human0.73518994
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71687168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.46161474
2MP0003646_muscle_fatigue4.19959604
3MP0006036_abnormal_mitochondrial_physio3.60916691
4MP0003186_abnormal_redox_activity3.56763545
5MP0003693_abnormal_embryo_hatching3.44500567
6MP0002837_dystrophic_cardiac_calcinosis3.41749815
7MP0003806_abnormal_nucleotide_metabolis2.81354791
8MP0000749_muscle_degeneration2.62406550
9MP0001986_abnormal_taste_sensitivity2.34024075
10MP0006292_abnormal_olfactory_placode2.18058170
11MP0006035_abnormal_mitochondrial_morpho2.17074948
12MP0006072_abnormal_retinal_apoptosis2.07194675
13MP0005084_abnormal_gallbladder_morpholo2.07050646
14MP0002653_abnormal_ependyma_morphology2.06966531
15MP0002638_abnormal_pupillary_reflex2.05028709
16MP0001293_anophthalmia1.95613162
17MP0008058_abnormal_DNA_repair1.92981458
18MP0000566_synostosis1.83801442
19MP0006276_abnormal_autonomic_nervous1.81166711
20MP0000750_abnormal_muscle_regeneration1.76240677
21MP0008932_abnormal_embryonic_tissue1.65969242
22MP0000751_myopathy1.62117834
23MP0002148_abnormal_hypersensitivity_rea1.61297831
24MP0000372_irregular_coat_pigmentation1.59877462
25MP0002132_abnormal_respiratory_system1.58935483
26MP0009785_altered_susceptibility_to1.58370444
27MP0009697_abnormal_copulation1.56468894
28MP0005330_cardiomyopathy1.56130997
29MP0004084_abnormal_cardiac_muscle1.54772259
30MP0008995_early_reproductive_senescence1.52918723
31MP0005083_abnormal_biliary_tract1.51870110
32MP0003724_increased_susceptibility_to1.51502241
33MP0000631_abnormal_neuroendocrine_gland1.49682344
34MP0003880_abnormal_central_pattern1.49645620
35MP0004133_heterotaxia1.49223256
36MP0005408_hypopigmentation1.48302509
37MP0003195_calcinosis1.48242596
38MP0005636_abnormal_mineral_homeostasis1.47967627
39MP0003315_abnormal_perineum_morphology1.46993383
40MP0003656_abnormal_erythrocyte_physiolo1.45445510
41MP0009333_abnormal_splenocyte_physiolog1.43929889
42MP0001485_abnormal_pinna_reflex1.42540106
43MP0004215_abnormal_myocardial_fiber1.42463025
44MP0001529_abnormal_vocalization1.41936555
45MP0003123_paternal_imprinting1.41484042
46MP0000343_altered_response_to1.39882627
47MP0003137_abnormal_impulse_conducting1.37157839
48MP0008875_abnormal_xenobiotic_pharmacok1.36851959
49MP0004036_abnormal_muscle_relaxation1.36622549
50MP0004957_abnormal_blastocyst_morpholog1.36602011
51MP0005551_abnormal_eye_electrophysiolog1.36205485
52MP0001984_abnormal_olfaction1.35054706
53MP0005394_taste/olfaction_phenotype1.34511292
54MP0005499_abnormal_olfactory_system1.34511292
55MP0003938_abnormal_ear_development1.31334413
56MP0003718_maternal_effect1.30737744
57MP0003122_maternal_imprinting1.28476258
58MP0001905_abnormal_dopamine_level1.28324211
59MP0002234_abnormal_pharynx_morphology1.27882978
60MP0003121_genomic_imprinting1.27455184
61MP0000358_abnormal_cell_content/1.26691935
62MP0008877_abnormal_DNA_methylation1.24716880
63MP0001853_heart_inflammation1.23738320
64MP0002751_abnormal_autonomic_nervous1.20698263
65MP0005646_abnormal_pituitary_gland1.17303374
66MP0001968_abnormal_touch/_nociception1.16570929
67MP0002938_white_spotting1.16241173
68MP0002972_abnormal_cardiac_muscle1.15222405
69MP0003878_abnormal_ear_physiology1.14774371
70MP0005377_hearing/vestibular/ear_phenot1.14774371
71MP0001544_abnormal_cardiovascular_syste1.13930468
72MP0005385_cardiovascular_system_phenoty1.13930468
73MP0001764_abnormal_homeostasis1.13391596
74MP0002163_abnormal_gland_morphology1.12697236
75MP0002332_abnormal_exercise_endurance1.10591348
76MP0002095_abnormal_skin_pigmentation1.09603510
77MP0000026_abnormal_inner_ear1.09179933
78MP0002822_catalepsy1.08727117
79MP0002106_abnormal_muscle_physiology1.04755809
80MP0005332_abnormal_amino_acid1.04710314
81MP0005266_abnormal_metabolism1.03860835
82MP0002736_abnormal_nociception_after1.03838055
83MP0000538_abnormal_urinary_bladder1.03329914
84MP0004019_abnormal_vitamin_homeostasis1.02505901
85MP0005253_abnormal_eye_physiology1.02205222
86MP0010030_abnormal_orbit_morphology1.01963958
87MP0001188_hyperpigmentation1.00533672
88MP0009643_abnormal_urine_homeostasis0.99415088
89MP0001286_abnormal_eye_development0.99238594
90MP0010386_abnormal_urinary_bladder0.99215776
91MP0003136_yellow_coat_color0.99128777
92MP0005174_abnormal_tail_pigmentation0.99074261
93MP0005389_reproductive_system_phenotype0.98701862
94MP0000858_altered_metastatic_potential0.98695035
95MP0008469_abnormal_protein_level0.98662256
96MP0003786_premature_aging0.98138550
97MP0004145_abnormal_muscle_electrophysio0.97412739
98MP0000678_abnormal_parathyroid_gland0.96372711
99MP0005195_abnormal_posterior_eye0.96078721
100MP0002210_abnormal_sex_determination0.95645120
101MP0002282_abnormal_trachea_morphology0.95290850
102MP0002876_abnormal_thyroid_physiology0.94810257
103MP0008789_abnormal_olfactory_epithelium0.94405986
104MP0003011_delayed_dark_adaptation0.94262709
105MP0001835_abnormal_antigen_presentation0.94162036
106MP0004043_abnormal_pH_regulation0.94068580
107MP0002160_abnormal_reproductive_system0.93815153
108MP0003436_decreased_susceptibility_to0.93173236
109MP0005645_abnormal_hypothalamus_physiol0.93129230
110MP0008872_abnormal_physiological_respon0.92372292
111MP0001346_abnormal_lacrimal_gland0.91987622
112MP0005319_abnormal_enzyme/_coenzyme0.88655515
113MP0002697_abnormal_eye_size0.88383832
114MP0003567_abnormal_fetal_cardiomyocyte0.88342837
115MP0008775_abnormal_heart_ventricle0.87804749
116MP0005025_abnormal_response_to0.87286342
117MP0002735_abnormal_chemical_nociception0.86757189
118MP0003787_abnormal_imprinting0.86599813
119MP0002233_abnormal_nose_morphology0.86323530
120MP0000759_abnormal_skeletal_muscle0.86123607
121MP0003937_abnormal_limbs/digits/tail_de0.84595632
122MP0004142_abnormal_muscle_tone0.84460128
123MP0003283_abnormal_digestive_organ0.83706283
124MP0000049_abnormal_middle_ear0.82984851
125MP0001542_abnormal_bone_strength0.82819239
126MP0005451_abnormal_body_composition0.82667873
127MP0003221_abnormal_cardiomyocyte_apopto0.82570096
128MP0002693_abnormal_pancreas_physiology0.82234116
129MP0002752_abnormal_somatic_nervous0.81802444
130MP0005171_absent_coat_pigmentation0.81743648
131MP0009764_decreased_sensitivity_to0.80493773
132MP0003828_pulmonary_edema0.79754288
133MP0004742_abnormal_vestibular_system0.79726374
134MP0009046_muscle_twitch0.78329324
135MP0001727_abnormal_embryo_implantation0.78267660
136MP0004147_increased_porphyrin_level0.78059793
137MP0005391_vision/eye_phenotype0.77489115
138MP0001663_abnormal_digestive_system0.77290589
139MP0001919_abnormal_reproductive_system0.76691870
140MP0009745_abnormal_behavioral_response0.75869411
141MP0005369_muscle_phenotype0.75820659
142MP0002272_abnormal_nervous_system0.75523978
143MP0005379_endocrine/exocrine_gland_phen0.75329398
144MP0010094_abnormal_chromosome_stability0.74831130
145MP0000490_abnormal_crypts_of0.74795534
146MP0000653_abnormal_sex_gland0.74609863
147MP0005165_increased_susceptibility_to0.74546888
148MP0002139_abnormal_hepatobiliary_system0.74304138
149MP0003077_abnormal_cell_cycle0.74126107
150MP0001324_abnormal_eye_pigmentation0.72892658
151MP0002277_abnormal_respiratory_mucosa0.72792491
152MP0001145_abnormal_male_reproductive0.72788773
153MP0005376_homeostasis/metabolism_phenot0.72455258
154MP0003279_aneurysm0.72428337
155MP0002102_abnormal_ear_morphology0.72032263
156MP0005000_abnormal_immune_tolerance0.71593815
157MP0000681_abnormal_thyroid_gland0.71545144
158MP0005620_abnormal_muscle_contractility0.71037871
159MP0005671_abnormal_response_to0.69347377

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.40162414
2Abnormal mitochondria in muscle tissue (HP:0008316)6.88964227
3Mitochondrial inheritance (HP:0001427)6.54159555
4Acute encephalopathy (HP:0006846)6.28581839
5Progressive macrocephaly (HP:0004481)6.02136134
6Hepatocellular necrosis (HP:0001404)5.92876642
7Hepatic necrosis (HP:0002605)5.67278698
8Increased CSF lactate (HP:0002490)5.58296041
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)5.22436663
10Decreased activity of mitochondrial respiratory chain (HP:0008972)5.22436663
11Abnormality of cells of the erythroid lineage (HP:0012130)5.13461592
12Increased hepatocellular lipid droplets (HP:0006565)5.00307348
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.96141626
14Lipid accumulation in hepatocytes (HP:0006561)4.76596195
15Abnormal number of erythroid precursors (HP:0012131)4.63764042
16Cerebral edema (HP:0002181)4.53064947
17Increased intramyocellular lipid droplets (HP:0012240)4.51167457
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.42200255
19Renal Fanconi syndrome (HP:0001994)4.36084969
20Exercise intolerance (HP:0003546)4.18342443
21Increased muscle lipid content (HP:0009058)4.13810922
22Lactic acidosis (HP:0003128)4.13078438
23Respiratory failure (HP:0002878)4.07535704
24Exertional dyspnea (HP:0002875)3.96355220
253-Methylglutaconic aciduria (HP:0003535)3.84104521
26Increased serum lactate (HP:0002151)3.76062460
27Optic disc pallor (HP:0000543)3.62344455
28Reticulocytopenia (HP:0001896)3.53981475
29Macrocytic anemia (HP:0001972)3.21252399
30Leukodystrophy (HP:0002415)3.10530130
31Respiratory difficulties (HP:0002880)3.09206769
32Pallor (HP:0000980)2.99449594
33Congenital, generalized hypertrichosis (HP:0004540)2.95215191
34Abnormality of renal resorption (HP:0011038)2.88697561
35Pancreatic fibrosis (HP:0100732)2.83565789
36Molar tooth sign on MRI (HP:0002419)2.80303255
37Abnormality of midbrain morphology (HP:0002418)2.80303255
38Glycosuria (HP:0003076)2.79944277
39Abnormality of urine glucose concentration (HP:0011016)2.79944277
40Pancreatic cysts (HP:0001737)2.72349470
41Lethargy (HP:0001254)2.66538965
42Septo-optic dysplasia (HP:0100842)2.63333091
43Hyperphosphaturia (HP:0003109)2.61903081
44True hermaphroditism (HP:0010459)2.60860074
45Generalized aminoaciduria (HP:0002909)2.52653887
46Myotonia (HP:0002486)2.50265396
47Abnormal hemoglobin (HP:0011902)2.46330348
48CNS demyelination (HP:0007305)2.45388108
49Palpitations (HP:0001962)2.44140927
50Colon cancer (HP:0003003)2.37553819
51Medial flaring of the eyebrow (HP:0010747)2.31683024
52Sclerocornea (HP:0000647)2.26914085
53Nephronophthisis (HP:0000090)2.26210016
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25444309
55Dicarboxylic aciduria (HP:0003215)2.25444309
56Aplastic anemia (HP:0001915)2.22962010
57Neuroendocrine neoplasm (HP:0100634)2.22065850
58Multiple enchondromatosis (HP:0005701)2.16279294
59Emotional lability (HP:0000712)2.15448956
60Type I transferrin isoform profile (HP:0003642)2.14024915
61Nausea (HP:0002018)2.13453599
62Abnormal urine phosphate concentration (HP:0012599)2.11251253
63Increased serum pyruvate (HP:0003542)2.10025841
64Abnormality of glycolysis (HP:0004366)2.10025841
65Rib fusion (HP:0000902)2.08932536
66X-linked dominant inheritance (HP:0001423)2.08500478
67Methylmalonic acidemia (HP:0002912)2.08118512
68Ragged-red muscle fibers (HP:0003200)2.07460172
69Pheochromocytoma (HP:0002666)2.05584337
70Myokymia (HP:0002411)2.04271104
71Hyperglycinemia (HP:0002154)2.03909026
72Absent thumb (HP:0009777)2.03463439
73Concave nail (HP:0001598)2.00877667
74Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00765611
75Renal tubular dysfunction (HP:0000124)2.00579889
76Abnormality of the heme biosynthetic pathway (HP:0010472)2.00227566
77Ventricular tachycardia (HP:0004756)1.99780352
78Conjunctival hamartoma (HP:0100780)1.98093945
79Vomiting (HP:0002013)1.96161695
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96146385
81Partial duplication of thumb phalanx (HP:0009944)1.94499540
82Esophageal neoplasm (HP:0100751)1.94367027
83Neoplasm of head and neck (HP:0012288)1.94367027
84Amniotic constriction ring (HP:0009775)1.93785255
85Abnormality of placental membranes (HP:0011409)1.93785255
86Absent septum pellucidum (HP:0001331)1.93272203
87Hypothermia (HP:0002045)1.89112314
88Microvesicular hepatic steatosis (HP:0001414)1.88802286
89Abnormal respiratory motile cilium physiology (HP:0012261)1.86851208
90Sudden death (HP:0001699)1.84678985
91Abnormality of aromatic amino acid family metabolism (HP:0004338)1.84121924
92Stenosis of the external auditory canal (HP:0000402)1.83716943
93Gliosis (HP:0002171)1.82208960
94Rhabdomyolysis (HP:0003201)1.82025088
95Progressive muscle weakness (HP:0003323)1.81596083
96Progressive external ophthalmoplegia (HP:0000590)1.80770416
97Maternal diabetes (HP:0009800)1.79891308
98Congenital primary aphakia (HP:0007707)1.79869650
99Anophthalmia (HP:0000528)1.77844728
100Gait imbalance (HP:0002141)1.77284827
101Partial duplication of the phalanx of hand (HP:0009999)1.76835156
102Pancytopenia (HP:0001876)1.76688083
103Cleft eyelid (HP:0000625)1.76310259
104Proximal tubulopathy (HP:0000114)1.75956272
105Abnormality of fatty-acid metabolism (HP:0004359)1.75539609
106Muscle stiffness (HP:0003552)1.74783802
107Male pseudohermaphroditism (HP:0000037)1.73632407
108Lipoatrophy (HP:0100578)1.73590911
109Calf muscle hypertrophy (HP:0008981)1.72442689
110Anencephaly (HP:0002323)1.71807080
111Congenital stationary night blindness (HP:0007642)1.71037322
112Abnormal ciliary motility (HP:0012262)1.70750900
113Abnormality of the labia minora (HP:0012880)1.69078567
114Abnormality of the renal medulla (HP:0100957)1.68772288
115Blindness (HP:0000618)1.68142627
116Nephrogenic diabetes insipidus (HP:0009806)1.66689258
117Depressed nasal ridge (HP:0000457)1.66653738
118Sparse eyelashes (HP:0000653)1.66028882
119Triphalangeal thumb (HP:0001199)1.64465348
120Myoglobinuria (HP:0002913)1.64439087
121Methylmalonic aciduria (HP:0012120)1.62514612
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60700713
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.60523440
124Poor head control (HP:0002421)1.60334313
125Muscle hypertrophy of the lower extremities (HP:0008968)1.60192032
126Abnormal respiratory epithelium morphology (HP:0012253)1.60043021
127Trismus (HP:0000211)1.59635247
128Reduced antithrombin III activity (HP:0001976)1.58370790
129Neoplasm of the adrenal gland (HP:0100631)1.57839819
130Testicular atrophy (HP:0000029)1.56751087
131Redundant skin (HP:0001582)1.55486103
132Dilated cardiomyopathy (HP:0001644)1.55134001
133Hypoglycemic coma (HP:0001325)1.54818357
134Aplasia/hypoplasia of the uterus (HP:0008684)1.52467689
135Muscle fiber atrophy (HP:0100295)1.52357171
136Pulmonary artery stenosis (HP:0004415)1.48690552
137Abnormal protein N-linked glycosylation (HP:0012347)1.48151324
138Abnormal protein glycosylation (HP:0012346)1.48151324
139Abnormal glycosylation (HP:0012345)1.48151324
140Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.48151324
141Oral leukoplakia (HP:0002745)1.47643966

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.77128210
2VRK26.12387095
3PIM23.51580085
4STK163.45164033
5NME12.92099364
6ARAF2.73721840
7MYLK2.56899172
8LIMK12.55469138
9MUSK2.46986304
10INSRR2.39527113
11BCKDK2.32614590
12TLK12.32354021
13CDC72.26218659
14NUAK12.18610612
15TESK12.09376324
16VRK12.08105552
17GRK52.02546590
18MAP3K122.01861171
19TAF11.98267765
20BRAF1.95635267
21EIF2AK11.91119787
22BUB11.90301330
23IRAK31.89558236
24WNK31.69763376
25TESK21.67545226
26ABL21.55092275
27IRAK41.53668239
28MAP4K21.44838471
29EIF2AK31.43747265
30KDR1.40817744
31MAPKAPK31.38022683
32PLK41.34522873
33GRK11.33909164
34MAP3K111.32800592
35DAPK31.21277394
36SRPK11.20712857
37PLK31.20178387
38IRAK11.19728965
39PBK1.19198921
40OBSCN1.17617389
41CDK81.16279221
42MAP2K71.14484902
43ZAK1.12146956
44ILK1.09770193
45DYRK31.06181490
46IRAK21.03098484
47MAPK151.00965231
48TNIK0.95270217
49DYRK20.94989909
50PLK10.94802872
51NEK10.93511656
52PDK20.92962228
53PIK3CG0.88303758
54ERN10.83474618
55GRK70.83146143
56CASK0.82907239
57CSNK1G30.78241832
58MST40.77341473
59WEE10.76308597
60PINK10.74722454
61MAP3K40.74700785
62PASK0.74519369
63AURKA0.74508149
64PRKCG0.73442025
65STK38L0.72181647
66SIK30.70778231
67RPS6KA50.69934343
68TBK10.69680882
69CSNK1G20.69246818
70CHEK20.68983723
71CSNK1G10.68284670
72TEC0.67731622
73FGFR20.67118377
74ADRBK20.66332145
75BMPR1B0.66235502
76LMTK20.65661553
77LRRK20.63277025
78BRSK10.63254376
79MAP2K20.62646408
80PAK10.61422580
81TRIM280.61173437
82BLK0.60460398
83WNK40.60249513
84LATS20.60151332
85TTK0.59230689
86OXSR10.56083282
87PNCK0.56078856
88FLT30.55586266
89RPS6KB20.55339850
90BRSK20.55226814
91RPS6KC10.54654760
92RPS6KL10.54654760
93NEK20.54538204
94RPS6KA40.54027596
95STK40.53141995
96CSNK2A10.52714344
97MOS0.51983761
98PRKCI0.51757251
99RPS6KA60.51223594
100ATR0.50216175
101CDK190.47956746
102EPHB20.47034333
103BMPR20.46681886
104PRKG20.46464467
105ADRBK10.45165694
106BTK0.44499289
107MAPKAPK50.44006548
108CCNB10.43957833
109PIM10.43840513
110AURKB0.43503940
111IKBKB0.42409613
112EIF2AK20.41849897
113PRKACA0.40600293
114IKBKE0.40581201
115PRKCE0.40532310
116CSNK1A10.40274601
117MAPKAPK20.40159679
118CAMK2D0.39338670
119TYK20.38679499
120CSNK1E0.38215635
121PAK30.37770434
122DAPK10.37715367
123PHKG10.37224260
124PHKG20.37224260
125TXK0.37130446
126CAMK2G0.37091280
127EPHA40.36675487
128PLK20.35594670
129TGFBR10.35460330
130CSNK1A1L0.35226496
131PRKCD0.34379161
132CSNK2A20.33576951
133TIE10.33493707
134NEK90.30803692
135STK390.30679515
136MST1R0.30144390
137ACVR1B0.30106709
138KIT0.29850590
139MAPK130.29796235
140MAPK40.28704480
141MAP3K50.27292840
142LYN0.25426657
143MKNK20.25334915
144MKNK10.25123661
145ZAP700.25082592

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.70664725
2Ribosome_Homo sapiens_hsa030105.63166994
3Parkinsons disease_Homo sapiens_hsa050125.21728884
4Huntingtons disease_Homo sapiens_hsa050163.77975414
5Alzheimers disease_Homo sapiens_hsa050103.68447300
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.56125679
7Proteasome_Homo sapiens_hsa030503.48106178
8RNA polymerase_Homo sapiens_hsa030203.04936623
9Protein export_Homo sapiens_hsa030602.80096904
10Cardiac muscle contraction_Homo sapiens_hsa042602.56164922
11Pyrimidine metabolism_Homo sapiens_hsa002402.22029148
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69017876
13DNA replication_Homo sapiens_hsa030301.67731022
14Sulfur relay system_Homo sapiens_hsa041221.59839735
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59107462
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55045263
17Homologous recombination_Homo sapiens_hsa034401.30909370
18Spliceosome_Homo sapiens_hsa030401.28776911
19Folate biosynthesis_Homo sapiens_hsa007901.28470933
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22488837
21Nucleotide excision repair_Homo sapiens_hsa034201.17244391
22Purine metabolism_Homo sapiens_hsa002301.12808151
23Sulfur metabolism_Homo sapiens_hsa009201.08962594
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06821446
25Mismatch repair_Homo sapiens_hsa034301.05744227
26Glutathione metabolism_Homo sapiens_hsa004801.04382152
27Base excision repair_Homo sapiens_hsa034100.97908735
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95779648
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92928620
30Metabolic pathways_Homo sapiens_hsa011000.90821362
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88383188
32Propanoate metabolism_Homo sapiens_hsa006400.85385174
33Phototransduction_Homo sapiens_hsa047440.85324297
34Peroxisome_Homo sapiens_hsa041460.84711692
35Carbon metabolism_Homo sapiens_hsa012000.83833476
36Pyruvate metabolism_Homo sapiens_hsa006200.81168030
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78758036
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77489862
39Basal transcription factors_Homo sapiens_hsa030220.75210860
40RNA degradation_Homo sapiens_hsa030180.75081473
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74998008
42Arachidonic acid metabolism_Homo sapiens_hsa005900.74433054
43Fatty acid elongation_Homo sapiens_hsa000620.71127375
44Nitrogen metabolism_Homo sapiens_hsa009100.69170137
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.69006224
46Phenylalanine metabolism_Homo sapiens_hsa003600.67589439
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61280759
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61090139
49Tyrosine metabolism_Homo sapiens_hsa003500.60403172
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59354835
51RNA transport_Homo sapiens_hsa030130.59319687
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59039044
53Collecting duct acid secretion_Homo sapiens_hsa049660.57609835
54Pentose phosphate pathway_Homo sapiens_hsa000300.57546013
55Arginine and proline metabolism_Homo sapiens_hsa003300.55045244
56Chemical carcinogenesis_Homo sapiens_hsa052040.53136995
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.51342701
58Linoleic acid metabolism_Homo sapiens_hsa005910.51127359
59Vitamin digestion and absorption_Homo sapiens_hsa049770.49742513
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49256061
61Basal cell carcinoma_Homo sapiens_hsa052170.49170772
62Steroid biosynthesis_Homo sapiens_hsa001000.49072886
63Fructose and mannose metabolism_Homo sapiens_hsa000510.48582956
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.48054179
65Selenocompound metabolism_Homo sapiens_hsa004500.45616698
66Galactose metabolism_Homo sapiens_hsa000520.44865785
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44834491
68Vibrio cholerae infection_Homo sapiens_hsa051100.44117455
69Fanconi anemia pathway_Homo sapiens_hsa034600.43858226
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42032117
71Fatty acid degradation_Homo sapiens_hsa000710.41799968
72Epstein-Barr virus infection_Homo sapiens_hsa051690.41793996
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.41609900
74Non-homologous end-joining_Homo sapiens_hsa034500.40530751
75Regulation of autophagy_Homo sapiens_hsa041400.40357970
76Caffeine metabolism_Homo sapiens_hsa002320.40052094
77p53 signaling pathway_Homo sapiens_hsa041150.39977247
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39843571
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38754401
80Rheumatoid arthritis_Homo sapiens_hsa053230.38602398
81beta-Alanine metabolism_Homo sapiens_hsa004100.36159657
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35996846
83Legionellosis_Homo sapiens_hsa051340.35211950
84Asthma_Homo sapiens_hsa053100.33250769
85Allograft rejection_Homo sapiens_hsa053300.32838702
86Systemic lupus erythematosus_Homo sapiens_hsa053220.32013433
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31819693
88One carbon pool by folate_Homo sapiens_hsa006700.31801131
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31769977
90Biosynthesis of amino acids_Homo sapiens_hsa012300.31403887
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31355985
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31326274
93Hedgehog signaling pathway_Homo sapiens_hsa043400.30408345
94Graft-versus-host disease_Homo sapiens_hsa053320.28140019
95N-Glycan biosynthesis_Homo sapiens_hsa005100.27946271
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26951891
97Nicotine addiction_Homo sapiens_hsa050330.26566009
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25308276
99Phagosome_Homo sapiens_hsa041450.25239889
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25037077
101Mineral absorption_Homo sapiens_hsa049780.23674981
102Cell cycle_Homo sapiens_hsa041100.23514877
103Vitamin B6 metabolism_Homo sapiens_hsa007500.22449045
104Ether lipid metabolism_Homo sapiens_hsa005650.22087025
105Starch and sucrose metabolism_Homo sapiens_hsa005000.19160827
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18228036
107Other glycan degradation_Homo sapiens_hsa005110.18122059
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18035086
109Histidine metabolism_Homo sapiens_hsa003400.17406796
110Fat digestion and absorption_Homo sapiens_hsa049750.16057819
111Butanoate metabolism_Homo sapiens_hsa006500.15757128
112Alcoholism_Homo sapiens_hsa050340.15753946
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15676289
114Tryptophan metabolism_Homo sapiens_hsa003800.14654896
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13351468
116Fatty acid metabolism_Homo sapiens_hsa012120.13295798
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.12520723
118Retinol metabolism_Homo sapiens_hsa008300.11588486
119Pertussis_Homo sapiens_hsa051330.10104348
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.10036239
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.09898997
122Hematopoietic cell lineage_Homo sapiens_hsa046400.09773179

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