ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	7.72131433
2	* acrosome reaction (GO:0007340)	7.28408413
3	* sperm motility (GO:0030317)	7.24220882
4	response to pheromone (GO:0019236)	7.17857820
5	tyrosine metabolic process (GO:0006570)	7.00648737
6	melanocyte differentiation (GO:0030318)	6.46459618
7	* fusion of sperm to egg plasma membrane (GO:0007342)	6.24334312
8	pigment cell differentiation (GO:0050931)	6.18856571
9	sperm capacitation (GO:0048240)	6.14943865
10	phenol-containing compound biosynthetic process (GO:0046189)	5.90157546
11	cilium or flagellum-dependent cell motility (GO:0001539)	5.73569041
12	developmental pigmentation (GO:0048066)	5.66583254
13	spermatid development (GO:0007286)	5.48207360
14	ketone body metabolic process (GO:1902224)	5.35561337
15	motile cilium assembly (GO:0044458)	5.31741817
16	epithelial cilium movement (GO:0003351)	4.92656733
17	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.84387883
18	multicellular organism reproduction (GO:0032504)	4.75815814
19	sperm-egg recognition (GO:0035036)	4.74232985
20	cilium movement (GO:0003341)	4.73815075
21	* plasma membrane fusion (GO:0045026)	4.71093974
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.70920524
23	binding of sperm to zona pellucida (GO:0007339)	4.63039704
24	negative regulation of inclusion body assembly (GO:0090084)	4.54697883
25	phosphatidylethanolamine metabolic process (GO:0046337)	4.51243406
26	secondary metabolic process (GO:0019748)	4.51066874
27	microtubule depolymerization (GO:0007019)	4.49798928
28	regulation of cilium movement (GO:0003352)	4.42463364
29	pigment biosynthetic process (GO:0046148)	4.32605936
30	melanosome organization (GO:0032438)	4.25996579
31	microtubule severing (GO:0051013)	4.17949905
32	DNA packaging (GO:0006323)	4.15827000
33	reproduction (GO:0000003)	4.14404339
34	neuroepithelial cell differentiation (GO:0060563)	4.10650036
35	single strand break repair (GO:0000012)	4.05279326
36	pigment granule organization (GO:0048753)	4.04734585
37	chromosome condensation (GO:0030261)	3.99502027
38	protein polyglutamylation (GO:0018095)	3.99283008
39	pigmentation (GO:0043473)	3.97053160
40	* calcium ion-dependent exocytosis (GO:0017156)	3.90937890
41	microtubule polymerization or depolymerization (GO:0031109)	3.87177026
42	organic cation transport (GO:0015695)	3.86788556
43	piRNA metabolic process (GO:0034587)	3.80600026
44	male meiosis (GO:0007140)	3.74244412
45	cell-cell recognition (GO:0009988)	3.70079342
46	pigment metabolic process (GO:0042440)	3.68949030
47	cellular ketone body metabolic process (GO:0046950)	3.62653963
48	* spermatogenesis (GO:0007283)	3.58799237
49	* male gamete generation (GO:0048232)	3.57615770
50	short-chain fatty acid metabolic process (GO:0046459)	3.48209945
51	synapsis (GO:0007129)	3.47161636
52	DNA methylation involved in gamete generation (GO:0043046)	3.45342608
53	retinal rod cell development (GO:0046548)	3.44357794
54	single fertilization (GO:0007338)	3.42639387
55	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.42007501
56	coenzyme catabolic process (GO:0009109)	3.31878663
57	* gamete generation (GO:0007276)	3.25813161
58	spermatid nucleus differentiation (GO:0007289)	3.20669315
59	regulation of inclusion body assembly (GO:0090083)	3.19519300
60	cornea development in camera-type eye (GO:0061303)	3.19189953
61	endosome to melanosome transport (GO:0035646)	3.17516162
62	endosome to pigment granule transport (GO:0043485)	3.17516162
63	sexual reproduction (GO:0019953)	3.14026539
64	germ cell development (GO:0007281)	3.13069770
65	fertilization (GO:0009566)	3.13041894
66	carnitine metabolic process (GO:0009437)	3.10294486
67	intraciliary transport (GO:0042073)	3.07318489
68	response to parathyroid hormone (GO:0071107)	3.06178125
69	regulation of Rab GTPase activity (GO:0032313)	2.98568306
70	positive regulation of Rab GTPase activity (GO:0032851)	2.98568306
71	aromatic amino acid family metabolic process (GO:0009072)	2.94431147
72	phenol-containing compound metabolic process (GO:0018958)	2.87103630
73	centriole assembly (GO:0098534)	2.86364184
74	centriole replication (GO:0007099)	2.85547324
75	Golgi to endosome transport (GO:0006895)	2.83405658
76	axoneme assembly (GO:0035082)	2.82570121
77	basement membrane organization (GO:0071711)	2.82394586
78	desmosome organization (GO:0002934)	2.80706627
79	response to acidic pH (GO:0010447)	2.80308112
80	response to methylmercury (GO:0051597)	2.79629744
81	dendritic spine organization (GO:0097061)	2.79196114
82	* cellular process involved in reproduction in multicellular organism (GO:0022412)	2.78625163
83	columnar/cuboidal epithelial cell differentiation (GO:0002065)	2.77694122
84	ventricular system development (GO:0021591)	2.76143874
85	regulation of microtubule-based movement (GO:0060632)	2.69375502
86	chromosome organization involved in meiosis (GO:0070192)	2.69075183
87	regulation of female gonad development (GO:2000194)	2.68989970
88	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.68550266
89	* multicellular organismal reproductive process (GO:0048609)	2.66210959
90	enteric nervous system development (GO:0048484)	2.64573357
91	negative regulation of metanephros development (GO:0072217)	2.59819387
92	protein targeting to Golgi (GO:0000042)	2.56391254
93	positive regulation of neuroblast proliferation (GO:0002052)	2.54215669
94	establishment of protein localization to Golgi (GO:0072600)	2.52965107
95	outflow tract septum morphogenesis (GO:0003148)	2.51450512
96	left/right axis specification (GO:0070986)	2.50060122
97	cellular response to pH (GO:0071467)	2.49014852
98	melanin biosynthetic process (GO:0042438)	16.2757030
99	melanin metabolic process (GO:0006582)	14.8845883
100	secondary metabolite biosynthetic process (GO:0044550)	13.7124114

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.43998609
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.30710771
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.19831079
4	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18728010
5	AR_21572438_ChIP-Seq_LNCaP_Human	2.02410311
6	SMC4_20622854_ChIP-Seq_HELA_Human	2.01717173
7	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.89143488
8	MITF_21258399_ChIP-Seq_MELANOMA_Human	1.79676160
9	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.73641360
10	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.72761564
11	RBPJ_21746931_ChIP-Seq_IB4_Human	1.71438121
12	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.67213837
13	ERG_20517297_ChIP-Seq_VCAP_Human	1.66337071
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65616020
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.65446716
16	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.63477155
17	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.63408250
18	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.63043579
19	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62475680
20	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.62475680
21	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.61397473
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.61212191
23	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.61212191
24	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.59508943
25	CTCF_27219007_Chip-Seq_Bcells_Human	1.59432092
26	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.58764775
27	DROSHA_22980978_ChIP-Seq_HELA_Human	1.56905525
28	PHF8_20622853_ChIP-Seq_HELA_Human	1.56126059
29	E2F1_20622854_ChIP-Seq_HELA_Human	1.55222064
30	P53_21459846_ChIP-Seq_SAOS-2_Human	1.53233889
31	NANOG_20526341_ChIP-Seq_ESCs_Human	1.52959859
32	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.52625776
33	ETV1_20927104_ChIP-Seq_GIST48_Human	1.52420982
34	TP63_22573176_ChIP-Seq_HFKS_Human	1.51632684
35	BCOR_27268052_Chip-Seq_Bcells_Human	1.51109807
36	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.50706924
37	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.50629716
38	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.49119658
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.48899103
40	NFYB_21822215_ChIP-Seq_K562_Human	1.47905182
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46501178
42	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.45167102
43	PHF8_20622854_ChIP-Seq_HELA_Human	1.44958020
44	RAC3_21632823_ChIP-Seq_H3396_Human	1.44487305
45	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.43008315
46	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.39711852
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39395218
48	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.39331509
49	CTCF_20526341_ChIP-Seq_ESCs_Human	1.38846039
50	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.37418016
51	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.37114547
52	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.36773718
53	MYC_19829295_ChIP-Seq_ESCs_Human	1.36097824
54	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.35853864
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35343765
56	TBL1_22424771_ChIP-Seq_293T_Human	1.34846391
57	NFYA_21822215_ChIP-Seq_K562_Human	1.32272022
58	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.30892858
59	HOXB7_26014856_ChIP-Seq_BT474_Human	1.30401825
60	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.29840150
61	ERA_21632823_ChIP-Seq_H3396_Human	1.28159116
62	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.28148421
63	FUS_26573619_Chip-Seq_HEK293_Human	1.27958550
64	AR_25329375_ChIP-Seq_VCAP_Human	1.27040502
65	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.26590691
66	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.26439285
67	KLF5_25053715_ChIP-Seq_YYC3_Human	1.25679912
68	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.24495439
69	OCT4_20526341_ChIP-Seq_ESCs_Human	1.24400820
70	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.22552125
71	BCL6_27268052_Chip-Seq_Bcells_Human	1.22216140
72	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.20960169
73	AHR_22903824_ChIP-Seq_MCF-7_Human	1.17192834
74	LXR_22292898_ChIP-Seq_THP-1_Human	1.16247419
75	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.15050026
76	P68_20966046_ChIP-Seq_HELA_Human	1.14693947
77	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.14692248
78	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.13963383
79	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.13458934
80	P300_27268052_Chip-Seq_Bcells_Human	1.11126625
81	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.08788758
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08087985
83	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07352235
84	* PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07066992
85	TCF4_23295773_ChIP-Seq_U87_Human	1.05943516
86	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05603117
87	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05603117
88	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.04931791
89	STAT3_23295773_ChIP-Seq_U87_Human	1.04232714
90	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.03103132
91	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.02777031
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02393451
93	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02183440
94	TP63_23658742_ChIP-Seq_EP156T_Human	1.01513444
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01409461
96	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.00198169
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00115972
98	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.99815199
99	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99707481
100	P300_19829295_ChIP-Seq_ESCs_Human	0.99551496

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	9.01973235
2	MP0000372_irregular_coat_pigmentation	6.72781582
3	MP0005408_hypopigmentation	6.28735723
4	MP0003136_yellow_coat_color	5.62420044
5	MP0004381_abnormal_hair_follicle	4.66525400
6	MP0005075_abnormal_melanosome_morpholog	4.57717939
7	MP0000015_abnormal_ear_pigmentation	4.51047948
8	MP0002095_abnormal_skin_pigmentation	3.67545922
9	MP0005174_abnormal_tail_pigmentation	3.64891841
10	MP0005410_abnormal_fertilization	3.58290086
11	MP0000569_abnormal_digit_pigmentation	3.13444511
12	MP0000371_diluted_coat_color	3.06859064
13	MP0005377_hearing/vestibular/ear_phenot	2.83072538
14	MP0003878_abnormal_ear_physiology	2.83072538
15	MP0005257_abnormal_intraocular_pressure	2.58384667
16	MP0001324_abnormal_eye_pigmentation	2.24193434
17	MP0002938_white_spotting	2.23360125
18	MP0002075_abnormal_coat/hair_pigmentati	1.90119190
19	MP0002877_abnormal_melanocyte_morpholog	1.87640319
20	MP0005248_abnormal_Harderian_gland	1.86701984
21	MP0005670_abnormal_white_adipose	1.66656658
22	MP0001186_pigmentation_phenotype	1.62556849
23	MP0003698_abnormal_male_reproductive	1.43687844
24	MP0002822_catalepsy	1.26898569
25	MP0001929_abnormal_gametogenesis	1.17111400
26	MP0003646_muscle_fatigue	1.15332550
27	MP0005197_abnormal_uvea_morphology	1.14660720
28	MP0003123_paternal_imprinting	1.12915490
29	MP0005058_abnormal_lysosome_morphology	1.08155500
30	MP0003172_abnormal_lysosome_physiology	1.02081223
31	MP0002090_abnormal_vision	0.97535518
32	MP0005253_abnormal_eye_physiology	0.93195012
33	MP0003806_abnormal_nucleotide_metabolis	0.93047014
34	MP0002102_abnormal_ear_morphology	0.91169054
35	MP0002282_abnormal_trachea_morphology	0.88871763
36	MP0009379_abnormal_foot_pigmentation	0.88580356
37	MP0009697_abnormal_copulation	0.85676294
38	MP0002638_abnormal_pupillary_reflex	0.84976161
39	MP0002161_abnormal_fertility/fecundity	0.76334896
40	MP0005409_darkened_coat_color	0.74871643
41	MP0002249_abnormal_larynx_morphology	0.73115092
42	MP0001485_abnormal_pinna_reflex	0.67687767
43	MP0001984_abnormal_olfaction	0.60640703
44	MP0002229_neurodegeneration	0.60404494
45	MP0004885_abnormal_endolymph	0.59897990
46	MP0003718_maternal_effect	0.59437904
47	MP0005551_abnormal_eye_electrophysiolog	0.58490096
48	MP0001661_extended_life_span	0.58160663
49	MP0000367_abnormal_coat/_hair	0.56602614
50	MP0002132_abnormal_respiratory_system	0.55176689
51	MP0006138_congestive_heart_failure	0.55122155
52	MP0010234_abnormal_vibrissa_follicle	0.53296707
53	MP0000377_abnormal_hair_follicle	0.52896226
54	MP0002177_abnormal_outer_ear	0.51362227
55	MP0002210_abnormal_sex_determination	0.51314311
56	MP0001963_abnormal_hearing_physiology	0.48880495
57	MP0008875_abnormal_xenobiotic_pharmacok	0.48297836
58	MP0000678_abnormal_parathyroid_gland	0.44472315
59	MP0000920_abnormal_myelination	0.44077731
60	MP0001881_abnormal_mammary_gland	0.42275763
61	MP0000026_abnormal_inner_ear	0.41740849
62	MP0002098_abnormal_vibrissa_morphology	0.40906153
63	MP0005395_other_phenotype	0.40511163
64	MP0005391_vision/eye_phenotype	0.40006899
65	MP0001145_abnormal_male_reproductive	0.39458069
66	MP0005193_abnormal_anterior_eye	0.38693602
67	MP0000653_abnormal_sex_gland	0.36968821
68	MP0004019_abnormal_vitamin_homeostasis	0.36783849
69	MP0005365_abnormal_bile_salt	0.34280393
70	MP0000749_muscle_degeneration	0.32840459
71	MP0000427_abnormal_hair_cycle	0.31804122
72	MP0009384_cardiac_valve_regurgitation	0.29801061
73	MP0002876_abnormal_thyroid_physiology	0.28062325
74	MP0001270_distended_abdomen	0.27909087
75	MP0002067_abnormal_sensory_capabilities	0.27171937
76	MP0003632_abnormal_nervous_system	0.27015790
77	MP0000566_synostosis	0.26997682
78	MP0008569_lethality_at_weaning	0.26541209
79	MP0008260_abnormal_autophagy	0.26519426
80	MP0005195_abnormal_posterior_eye	0.26268114
81	MP0003868_abnormal_feces_composition	0.25700915
82	MP0009053_abnormal_anal_canal	0.24743318
83	MP0003936_abnormal_reproductive_system	0.24585043
84	MP0000383_abnormal_hair_follicle	0.24406582
85	MP0004233_abnormal_muscle_weight	0.24128277
86	MP0009046_muscle_twitch	0.24094147
87	MP0005085_abnormal_gallbladder_physiolo	0.23471720
88	MP0001905_abnormal_dopamine_level	0.22824062
89	MP0000627_abnormal_mammary_gland	0.22764368
90	MP0002168_other_aberrant_phenotype	0.21946341
91	MP0010678_abnormal_skin_adnexa	0.21087063
92	MP0000681_abnormal_thyroid_gland	0.20850598
93	MP0001348_abnormal_lacrimal_gland	0.20494730
94	MP0002653_abnormal_ependyma_morphology	0.20440254
95	MP0000639_abnormal_adrenal_gland	0.20070027
96	MP0008770_decreased_survivor_rate	0.19680425
97	MP0002160_abnormal_reproductive_system	0.19257551
98	MP0002909_abnormal_adrenal_gland	0.18941534
99	MP0001502_abnormal_circadian_rhythm	0.18692775
100	MP0005423_abnormal_somatic_nervous	0.18669485

Predicted human phenotypes

Rank	Gene Set	Z-score
1	White forelock (HP:0002211)	9.01401493
2	Patchy hypopigmentation of hair (HP:0011365)	8.40340933
3	Blue irides (HP:0000635)	7.23929220
4	Aplasia/Hypoplasia of the macula (HP:0008059)	6.72596788
5	Aplasia/Hypoplasia of the fovea (HP:0008060)	6.54545448
6	Hypoplasia of the fovea (HP:0007750)	6.54545448
7	Ocular albinism (HP:0001107)	6.47532196
8	Aplasia/Hypoplasia affecting the retina (HP:0008061)	6.26277069
9	Abnormality of the fovea (HP:0000493)	5.73736496
10	Iris hypopigmentation (HP:0007730)	5.55984493
11	Generalized hypopigmentation (HP:0007513)	5.13346485
12	Congenital sensorineural hearing impairment (HP:0008527)	4.84828525
13	Abnormal respiratory motile cilium morphology (HP:0005938)	4.78064529
14	Abnormal respiratory epithelium morphology (HP:0012253)	4.78064529
15	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.75229370
16	Hypopigmentation of the fundus (HP:0007894)	4.64066243
17	Hypoplasia of the iris (HP:0007676)	4.45047492
18	Albinism (HP:0001022)	4.42238648
19	Abnormal respiratory motile cilium physiology (HP:0012261)	4.33683866
20	Abnormal ciliary motility (HP:0012262)	4.21278146
21	Heterochromia iridis (HP:0001100)	4.16913955
22	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.12312774
23	Absent/shortened dynein arms (HP:0200106)	4.12312774
24	Abnormal auditory evoked potentials (HP:0006958)	4.10694083
25	Rhinitis (HP:0012384)	3.59946286
26	Severe visual impairment (HP:0001141)	3.59457779
27	Premature graying of hair (HP:0002216)	3.48228765
28	Peripheral hypomyelination (HP:0007182)	3.06091885
29	Spastic paraparesis (HP:0002313)	2.92079871
30	Absent epiphyses (HP:0010577)	2.91690085
31	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.91690085
32	Bell-shaped thorax (HP:0001591)	2.78082605
33	Abnormality of macular pigmentation (HP:0008002)	2.73761626
34	Chronic bronchitis (HP:0004469)	2.64698179
35	Cutaneous melanoma (HP:0012056)	2.63092062
36	Tubulointerstitial nephritis (HP:0001970)	2.62526260
37	Generalized hypopigmentation of hair (HP:0011358)	2.58128273
38	Nasal polyposis (HP:0100582)	2.56847939
39	Decreased central vision (HP:0007663)	2.53891772
40	Male infertility (HP:0003251)	2.52997187
41	Hand muscle atrophy (HP:0009130)	2.50872449
42	Lip pit (HP:0100267)	2.43506482
43	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.38141764
44	Infertility (HP:0000789)	2.37480123
45	Chronic hepatic failure (HP:0100626)	2.35896746
46	Hypoplastic ischia (HP:0003175)	2.31347997
47	Retinal dysplasia (HP:0007973)	2.27956783
48	Chronic sinusitis (HP:0011109)	2.27788866
49	Asymmetric septal hypertrophy (HP:0001670)	2.24845809
50	Freckling (HP:0001480)	2.22488306
51	Abnormal pupillary function (HP:0007686)	2.21749899
52	Enlarged epiphyses (HP:0010580)	2.20043557
53	Bronchiectasis (HP:0002110)	2.20041537
54	Bilateral sensorineural hearing impairment (HP:0008619)	2.19066083
55	Upper limb muscle weakness (HP:0003484)	2.12172572
56	Abnormality of the nasal mucosa (HP:0000433)	2.11079258
57	Bony spicule pigmentary retinopathy (HP:0007737)	2.08330617
58	Underdeveloped nasal alae (HP:0000430)	2.07284122
59	Paraparesis (HP:0002385)	2.06635216
60	Resting tremor (HP:0002322)	2.03891732
61	Cone-rod dystrophy (HP:0000548)	2.01044421
62	Atelectasis (HP:0100750)	1.97608991
63	Distal upper limb amyotrophy (HP:0007149)	1.97595856
64	Upper limb amyotrophy (HP:0009129)	1.97595856
65	Cerebral hypomyelination (HP:0006808)	1.92012286
66	Attenuation of retinal blood vessels (HP:0007843)	1.91464239
67	Hyperkalemia (HP:0002153)	1.85745058
68	Abnormality of the ischium (HP:0003174)	1.83437995
69	Epiphyseal dysplasia (HP:0002656)	1.80164894
70	J-shaped sella turcica (HP:0002680)	1.78376334
71	Vertebral clefting (HP:0008428)	1.71475660
72	Insidious onset (HP:0003587)	1.69167943
73	Termporal pattern (HP:0011008)	1.69167943
74	Photophobia (HP:0000613)	1.67947571
75	Occipital encephalocele (HP:0002085)	1.66518792
76	Congenital stationary night blindness (HP:0007642)	1.66399800
77	Postural instability (HP:0002172)	1.65953365
78	Abnormality of the nasal septum (HP:0000419)	1.65404144
79	Amblyopia (HP:0000646)	1.63650786
80	Facial cleft (HP:0002006)	1.62729182
81	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.61047108
82	Renal dysplasia (HP:0000110)	1.59471144
83	Abnormality of femoral epiphyses (HP:0006499)	1.58182838
84	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.58182838
85	Ulnar claw (HP:0001178)	1.57458004
86	Synophrys (HP:0000664)	1.57174333
87	Bronchitis (HP:0012387)	1.56791723
88	Horizontal nystagmus (HP:0000666)	1.55223559
89	Sex reversal (HP:0012245)	1.54947907
90	Abnormal sex determination (HP:0012244)	1.54947907
91	Macular degeneration (HP:0000608)	1.52018825
92	Morphological abnormality of the inner ear (HP:0011390)	1.50552948
93	Hypoalphalipoproteinemia (HP:0003233)	1.49945418
94	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.42710625
95	Recurrent otitis media (HP:0000403)	1.42480370
96	Beaking of vertebral bodies (HP:0004568)	1.41761300
97	Abnormality of the femoral head (HP:0003368)	1.41097138
98	Insulin-resistant diabetes mellitus (HP:0000831)	1.39777438
99	Astigmatism (HP:0000483)	1.39234762
100	Median cleft lip (HP:0000161)	1.36954393

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	DDR2	6.23365534
2	TESK1	4.52355779
3	MAPK15	3.94838849
4	MARK3	3.79627692
5	STK38	3.59997463
6	PLK4	3.44863171
7	WEE1	3.33389095
8	MST1R	3.10679898
9	CDK12	2.65303821
10	PRKD3	2.34419593
11	PLK2	2.13863437
12	INSRR	1.89534664
13	ACVR1B	1.81851248
14	CDK7	1.75663083
15	STK38L	1.72296219
16	BMPR1B	1.60662833
17	PDK2	1.55769338
18	BRD4	1.50293469
19	FER	1.48804465
20	LATS1	1.48178406
21	NEK6	1.39530990
22	ICK	1.37358269
23	TRIM28	1.36606540
24	PIK3CA	1.31762285
25	MAP3K6	1.26261725
26	MET	1.25356983
27	PTK2B	1.22975223
28	MAP3K3	1.19054479
29	PINK1	1.12986785
30	FRK	1.09193757
31	PRKAA2	1.08257706
32	CAMK1G	1.07079411
33	PDPK1	1.06709185
34	PIK3CG	1.03801412
35	LMTK2	1.03522516
36	MAP4K2	1.00302046
37	MAP3K2	0.96447892
38	PDK1	0.91962100
39	PRKCH	0.88343343
40	SIK3	0.86076171
41	PNCK	0.84695166
42	NTRK3	0.84195712
43	CDK3	0.82400608
44	CAMK1D	0.79331398
45	RIPK1	0.74786510
46	NEK2	0.68328047
47	NME2	0.66727418
48	ERBB4	0.65166035
49	ERBB2	0.64285061
50	PRKD1	0.62284614
51	MINK1	0.61868935
52	BCR	0.60607972
53	MAP2K1	0.58613022
54	EPHA2	0.54971343
55	TYRO3	0.54658437
56	MAP2K2	0.54153367
57	ERBB3	0.52963149
58	PRKCG	0.52610004
59	PAK3	0.52538339
60	MUSK	0.51452446
61	STK16	0.51375597
62	AKT2	0.50918623
63	LATS2	0.50474139
64	GRK6	0.46244480
65	TRIB3	0.43104710
66	MAPK1	0.42335514
67	MAP2K6	0.40962106
68	SGK1	0.40891485
69	MAPKAPK3	0.39664258
70	PRKAA1	0.39477493
71	RPS6KA1	0.39206608
72	RPS6KA2	0.39089476
73	STK3	0.36903584
74	PRKCB	0.35115737
75	GSK3B	0.34961029
76	TGFBR1	0.34902809
77	FGFR1	0.34769587
78	PRKACB	0.34034417
79	WNK1	0.32301498
80	CDK2	0.32126007
81	DYRK1B	0.32031420
82	PLK1	0.31900093
83	PHKG2	0.31519814
84	PHKG1	0.31519814
85	CAMK2A	0.31464165
86	GSK3A	0.29923185
87	CSNK1G2	0.29494384
88	CCNB1	0.27951830
89	PRKACA	0.27540443
90	MAPK14	0.26896638
91	CHEK1	0.26832046
92	CAMK1	0.25919111
93	RET	0.25603005
94	EGFR	0.24968433
95	CSNK1A1	0.24926628
96	STK39	0.23865365
97	ROCK1	0.23190824
98	CSNK1A1L	0.22739336
99	MAPK11	0.22319086
100	FGR	0.21865389

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Tyrosine metabolism_Homo sapiens_hsa00350	4.46030605
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.11760323
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.40803384
4	Phenylalanine metabolism_Homo sapiens_hsa00360	3.10206668
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.85425002
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.47299339
7	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.36810015
8	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.24031301
9	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.22315293
10	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.05279043
11	Chemical carcinogenesis_Homo sapiens_hsa05204	2.03782751
12	beta-Alanine metabolism_Homo sapiens_hsa00410	1.96525049
13	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.94682935
14	Retinol metabolism_Homo sapiens_hsa00830	1.94262807
15	Arginine and proline metabolism_Homo sapiens_hsa00330	1.87498549
16	Histidine metabolism_Homo sapiens_hsa00340	1.80451736
17	Propanoate metabolism_Homo sapiens_hsa00640	1.77700291
18	Sulfur relay system_Homo sapiens_hsa04122	1.76578297
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.74214146
20	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.72217569
21	Melanogenesis_Homo sapiens_hsa04916	1.70760324
22	Caffeine metabolism_Homo sapiens_hsa00232	1.67662472
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.56558249
24	Butanoate metabolism_Homo sapiens_hsa00650	1.55511650
25	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.51913379
26	Arginine biosynthesis_Homo sapiens_hsa00220	1.48691223
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.40552925
28	Fatty acid degradation_Homo sapiens_hsa00071	1.39615403
29	Olfactory transduction_Homo sapiens_hsa04740	1.38541630
30	Peroxisome_Homo sapiens_hsa04146	1.37203030
31	Glutathione metabolism_Homo sapiens_hsa00480	1.36776122
32	Fatty acid metabolism_Homo sapiens_hsa01212	1.36108039
33	Lysine degradation_Homo sapiens_hsa00310	1.34162236
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.32777679
35	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.31214333
36	PPAR signaling pathway_Homo sapiens_hsa03320	1.30392912
37	ABC transporters_Homo sapiens_hsa02010	1.27847991
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.26559308
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.18990866
40	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.15948815
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.05583252
42	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.01329885
43	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.97924227
44	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.95000274
45	Sphingolipid metabolism_Homo sapiens_hsa00600	0.94528217
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.94486123
47	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.88945753
48	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.88939766
49	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.87768063
50	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.83170395
51	Metabolic pathways_Homo sapiens_hsa01100	0.82033941
52	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.79720541
53	Pyruvate metabolism_Homo sapiens_hsa00620	0.75109457
54	Adherens junction_Homo sapiens_hsa04520	0.72994500
55	Bile secretion_Homo sapiens_hsa04976	0.72073554
56	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.70204283
57	Proteasome_Homo sapiens_hsa03050	0.69703195
58	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.69168596
59	Lysosome_Homo sapiens_hsa04142	0.68228258
60	Huntingtons disease_Homo sapiens_hsa05016	0.65623977
61	Linoleic acid metabolism_Homo sapiens_hsa00591	0.65544528
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.63969731
63	Circadian rhythm_Homo sapiens_hsa04710	0.63265375
64	Complement and coagulation cascades_Homo sapiens_hsa04610	0.63205923
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62464765
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62344465
67	Selenocompound metabolism_Homo sapiens_hsa00450	0.60300516
68	Non-homologous end-joining_Homo sapiens_hsa03450	0.56929661
69	Phototransduction_Homo sapiens_hsa04744	0.56761005
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.55777236
71	Folate biosynthesis_Homo sapiens_hsa00790	0.55287269
72	Fatty acid elongation_Homo sapiens_hsa00062	0.54729483
73	Nitrogen metabolism_Homo sapiens_hsa00910	0.53770605
74	Carbon metabolism_Homo sapiens_hsa01200	0.52779351
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51870396
76	Prostate cancer_Homo sapiens_hsa05215	0.51789472
77	Oocyte meiosis_Homo sapiens_hsa04114	0.51005127
78	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.48764263
79	Taste transduction_Homo sapiens_hsa04742	0.48680800
80	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.42394170
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40712508
82	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.38119872
83	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.36669086
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.35372115
85	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.30642888
86	Endocytosis_Homo sapiens_hsa04144	0.29890077
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.29193055
88	Morphine addiction_Homo sapiens_hsa05032	0.28742619
89	Sulfur metabolism_Homo sapiens_hsa00920	0.28434266
90	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.26686099
91	Vibrio cholerae infection_Homo sapiens_hsa05110	0.25676871
92	Tryptophan metabolism_Homo sapiens_hsa00380	0.25516886
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.23710626
94	Cocaine addiction_Homo sapiens_hsa05030	0.22182264
95	RNA polymerase_Homo sapiens_hsa03020	0.22180674
96	Estrogen signaling pathway_Homo sapiens_hsa04915	0.21974761
97	Insulin resistance_Homo sapiens_hsa04931	0.21317705
98	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.20616126
99	Purine metabolism_Homo sapiens_hsa00230	0.19519403
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.16117882

ROPN1B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »