ROPN1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ropporin family. The encoded protein is present in sperm and interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.65303036
2spermatid development (GO:0007286)9.52308138
3* epithelial cilium movement (GO:0003351)9.49389600
4piRNA metabolic process (GO:0034587)9.32463268
5reproduction (GO:0000003)9.17433390
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.61655897
7regulation of cilium movement (GO:0003352)8.46155441
8* cilium movement (GO:0003341)8.34954196
9male meiosis (GO:0007140)8.01806488
10synaptonemal complex organization (GO:0070193)7.77566008
11synaptonemal complex assembly (GO:0007130)7.59595257
12single fertilization (GO:0007338)7.38823615
13primary alcohol catabolic process (GO:0034310)6.51528503
14left/right axis specification (GO:0070986)6.42428720
15fertilization (GO:0009566)6.30564592
16negative regulation of inclusion body assembly (GO:0090084)6.27605154
17spermatogenesis (GO:0007283)6.14290226
18male gamete generation (GO:0048232)6.12163790
19organic cation transport (GO:0015695)6.05209774
20microtubule bundle formation (GO:0001578)5.98717042
21ventricular system development (GO:0021591)5.71055152
22vitamin transmembrane transport (GO:0035461)5.69192657
23tolerance induction (GO:0002507)5.64151903
24gamete generation (GO:0007276)5.61968104
25diterpenoid biosynthetic process (GO:0016102)5.60501884
26male meiosis I (GO:0007141)5.55696301
27DNA methylation involved in gamete generation (GO:0043046)5.55504509
28* sperm capacitation (GO:0048240)5.48961511
29microtubule depolymerization (GO:0007019)5.48446445
30germ cell development (GO:0007281)5.42808145
31ethanol metabolic process (GO:0006067)5.41912502
32regulation of inclusion body assembly (GO:0090083)5.32028472
33negative regulation of B cell mediated immunity (GO:0002713)5.25183356
34negative regulation of immunoglobulin mediated immune response (GO:0002890)5.25183356
35* cellular process involved in reproduction in multicellular organism (GO:0022412)5.21888284
36pyrimidine-containing compound transmembrane transport (GO:0072531)5.21691887
37chromosome organization involved in meiosis (GO:0070192)5.20569216
38regulation of microtubule-based movement (GO:0060632)4.99181202
39calcium ion-dependent exocytosis (GO:0017156)4.98185564
40seminiferous tubule development (GO:0072520)4.93214055
41cell recognition (GO:0008037)4.82030346
42meiotic nuclear division (GO:0007126)4.78783355
43microtubule severing (GO:0051013)4.77878644
44response to xenobiotic stimulus (GO:0009410)4.77767014
45left/right pattern formation (GO:0060972)4.67948461
46one-carbon compound transport (GO:0019755)4.64882193
47positive regulation of tolerance induction (GO:0002645)4.56921306
48meiosis I (GO:0007127)4.46753103
49negative regulation of humoral immune response (GO:0002921)4.44937383
50multicellular organismal reproductive process (GO:0048609)4.44160157
51lung epithelium development (GO:0060428)4.38369005
52spermatid nucleus differentiation (GO:0007289)4.37103562
53regulation of germinal center formation (GO:0002634)4.35005234
54meiotic cell cycle (GO:0051321)4.28502576
55negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.27763849
56negative regulation of T cell differentiation in thymus (GO:0033085)4.20214984
57cell projection assembly (GO:0030031)4.19437549
58regulation of interleukin-5 production (GO:0032674)4.17712946
59ethanol oxidation (GO:0006069)4.10363150
60protein localization to cilium (GO:0061512)4.09953913
61genitalia morphogenesis (GO:0035112)4.05223404
62glomerular epithelial cell development (GO:0072310)3.99075391
63monoubiquitinated protein deubiquitination (GO:0035520)3.94800044
64glycerol ether metabolic process (GO:0006662)3.94673512
65terpenoid biosynthetic process (GO:0016114)3.93226025
66establishment of apical/basal cell polarity (GO:0035089)3.85930983
67protein polyglutamylation (GO:0018095)3.79199726
68regulation of interleukin-13 production (GO:0032656)3.76929510
69chaperone-mediated protein complex assembly (GO:0051131)3.74517661
70regulation of tolerance induction (GO:0002643)3.70852291
71retinoic acid metabolic process (GO:0042573)3.64219352
72ether metabolic process (GO:0018904)3.63718641
73hydrogen peroxide biosynthetic process (GO:0050665)3.60737696
74chromosome condensation (GO:0030261)3.59556751
75multicellular organismal development (GO:0007275)3.53770052
76intraciliary transport (GO:0042073)3.53277011
77DNA packaging (GO:0006323)3.51981340
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.49483816
79gene silencing by RNA (GO:0031047)3.48521558
80axoneme assembly (GO:0035082)3.40781152
81carnitine transport (GO:0015879)3.39777377
82amino-acid betaine transport (GO:0015838)3.39777377
83sexual reproduction (GO:0019953)3.36992448
84reactive oxygen species biosynthetic process (GO:1903409)3.33945416
85cytoplasmic microtubule organization (GO:0031122)3.33768796
86negative regulation of organelle assembly (GO:1902116)3.30460895
87carnitine transmembrane transport (GO:1902603)3.30418048
88establishment or maintenance of monopolar cell polarity (GO:0061339)3.28874526
89establishment of monopolar cell polarity (GO:0061162)3.28874526
90alditol metabolic process (GO:0019400)3.25379205
91protein K11-linked deubiquitination (GO:0035871)3.22011756
92single strand break repair (GO:0000012)3.18266180
93* microtubule-based movement (GO:0007018)3.15640956
94lateral ventricle development (GO:0021670)3.14291815
95protein refolding (GO:0042026)3.11951918
96cilium organization (GO:0044782)3.10090112
97peptidyl-glutamic acid modification (GO:0018200)3.08992329
98meiotic cell cycle process (GO:1903046)3.06302690
99nucleoside diphosphate phosphorylation (GO:0006165)3.05458182
100retinol metabolic process (GO:0042572)3.05004153
101lactate metabolic process (GO:0006089)3.04269274
102glutathione derivative metabolic process (GO:1901685)3.01039995
103glutathione derivative biosynthetic process (GO:1901687)3.01039995
104regulation of centriole replication (GO:0046599)3.00233367
105cilium assembly (GO:0042384)2.96360523
106polyol catabolic process (GO:0046174)2.96012196
107primary alcohol metabolic process (GO:0034308)2.93094234
108regulation of spindle checkpoint (GO:0090231)2.92901657
109O-glycan processing (GO:0016266)2.92447463
110glycolytic process (GO:0006096)2.89740795
111regulation of interleukin-6 biosynthetic process (GO:0045408)2.88268211
112synapsis (GO:0007129)2.87525589
113hypotonic response (GO:0006971)2.86845773
114cilium morphogenesis (GO:0060271)2.85421649
115glycerol metabolic process (GO:0006071)2.84528118
116gas transport (GO:0015669)2.82908570
117cellular component assembly involved in morphogenesis (GO:0010927)2.82152111
118exogenous drug catabolic process (GO:0042738)2.80956297
119centriole assembly (GO:0098534)2.78585949
120nucleus organization (GO:0006997)2.77781362
121determination of left/right symmetry (GO:0007368)2.76821394
122centriole replication (GO:0007099)2.75158809
123establishment of planar polarity (GO:0001736)2.74598638
124establishment of tissue polarity (GO:0007164)2.74598638
125hydrogen peroxide catabolic process (GO:0042744)2.74362527
126microtubule polymerization or depolymerization (GO:0031109)2.73321239
127regulation of autophagic vacuole assembly (GO:2000785)2.73154079
128lipoxygenase pathway (GO:0019372)2.66584939
129negative regulation of lymphocyte mediated immunity (GO:0002707)2.66378133
130carnitine metabolic process (GO:0009437)2.65896583
131negative regulation of adaptive immune response (GO:0002820)2.65709401
132smoothened signaling pathway (GO:0007224)2.65063057
133phosphatidylcholine biosynthetic process (GO:0006656)2.64784850
134gene silencing (GO:0016458)2.64635053
135sequestering of actin monomers (GO:0042989)2.64294709
136mitotic sister chromatid cohesion (GO:0007064)2.64049444
137regulation of meiosis I (GO:0060631)2.63850937
138regulation of microtubule depolymerization (GO:0031114)2.62485111
139determination of bilateral symmetry (GO:0009855)2.62248947
140nuclear pore complex assembly (GO:0051292)2.60163272
141progesterone metabolic process (GO:0042448)2.57033260
142GTP biosynthetic process (GO:0006183)2.56291019
143specification of symmetry (GO:0009799)2.56251797
144mitochondrion degradation (GO:0000422)2.54562067
145organelle assembly (GO:0070925)2.54430791
146* microtubule-based process (GO:0007017)2.54126894
147phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.52520154
148positive regulation of smoothened signaling pathway (GO:0045880)2.52269183
149hydrogen peroxide metabolic process (GO:0042743)2.51607824
150regulation of cilium assembly (GO:1902017)2.49874721
151multicellular organismal water homeostasis (GO:0050891)2.48958226
152phosphatidylethanolamine biosynthetic process (GO:0006646)2.47398085
153regulation of protein polyubiquitination (GO:1902914)2.46339061
154regulation of vacuole organization (GO:0044088)2.42495795
155sialylation (GO:0097503)2.41216836
156superoxide anion generation (GO:0042554)2.37843571
157excretion (GO:0007588)2.37681041
158aldehyde catabolic process (GO:0046185)2.37164262
159regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.34355453
160retinal rod cell development (GO:0046548)2.33848676
161cilium or flagellum-dependent cell motility (GO:0001539)14.0701942
162fusion of sperm to egg plasma membrane (GO:0007342)13.2259189
163* sperm motility (GO:0030317)12.6733539
164cell wall macromolecule catabolic process (GO:0016998)11.5745716
165cell wall macromolecule metabolic process (GO:0044036)11.5745716
166sperm-egg recognition (GO:0035036)11.3408461
167acrosome reaction (GO:0007340)11.0769474
168axonemal dynein complex assembly (GO:0070286)11.0470003
169multicellular organism reproduction (GO:0032504)10.8327365
170acrosome assembly (GO:0001675)10.7962704
171binding of sperm to zona pellucida (GO:0007339)10.4530664
172cell-cell recognition (GO:0009988)10.1483983
173plasma membrane fusion (GO:0045026)10.0425114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.01892607
2EZH2_22144423_ChIP-Seq_EOC_Human4.64929308
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.43476099
4DROSHA_22980978_ChIP-Seq_HELA_Human3.26080839
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.22828718
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.91128159
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78887461
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.58761469
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49225775
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43401443
11* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.22869899
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22113421
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.12834006
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09289258
15VDR_22108803_ChIP-Seq_LS180_Human2.08261581
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.04774762
17* SMC4_20622854_ChIP-Seq_HELA_Human2.02805178
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.9888123
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.90025468
20STAT1_20625510_ChIP-Seq_HELA_Human1.89786041
21ZNF274_21170338_ChIP-Seq_K562_Hela1.85669004
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80977621
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78224722
24* RUNX1_27514584_Chip-Seq_MCF-7_Human1.76003355
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.73181434
26STAT1_17558387_ChIP-Seq_HELA_Human1.69123913
27TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.66237726
28SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.66203327
29TP63_22573176_ChIP-Seq_HFKS_Human1.64875735
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63335008
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63155026
32SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62154766
33P68_20966046_ChIP-Seq_HELA_Human1.60046136
34FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58873317
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.56172094
36KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.53998444
37RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.52665263
38GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.51901648
39KAP1_22055183_ChIP-Seq_ESCs_Mouse1.50820798
40SOX2_22085726_ChIP-Seq_NPCs_Mouse1.50168584
41* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49483924
42AHR_22903824_ChIP-Seq_MCF-7_Human1.48370435
43P63_26484246_Chip-Seq_KERATINOCYTES_Human1.47973241
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.46883905
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.46529669
46CBP_20019798_ChIP-Seq_JUKART_Human1.45625465
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45625465
48CTCF_20526341_ChIP-Seq_ESCs_Human1.43928688
49GATA3_21867929_ChIP-Seq_CD8_Mouse1.41845402
50PHF8_20622854_ChIP-Seq_HELA_Human1.41809496
51TP63_23658742_ChIP-Seq_EP156T_Human1.39947933
52* GATA1_19941826_ChIP-Seq_K562_Human1.39919010
53MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38980475
54SMRT_27268052_Chip-Seq_Bcells_Human1.38975145
55TDRD3_21172665_ChIP-Seq_MCF-7_Human1.38112150
56TAL1_26923725_Chip-Seq_HPCs_Mouse1.37838689
57KLF5_25053715_ChIP-Seq_YYC3_Human1.37057355
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.35279410
59P300_27268052_Chip-Seq_Bcells_Human1.34754345
60BCOR_27268052_Chip-Seq_Bcells_Human1.34417378
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34320380
62KDM2B_26808549_Chip-Seq_REH_Human1.33872457
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33290817
64BCL6_27268052_Chip-Seq_Bcells_Human1.32021521
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30796956
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29405311
67LXR_22292898_ChIP-Seq_THP-1_Human1.28983837
68LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28890411
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28518446
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.28108081
71TRIM28_21343339_ChIP-Seq_HEK293_Human1.27494681
72P53_21459846_ChIP-Seq_SAOS-2_Human1.26169922
73SPI1_23127762_ChIP-Seq_K562_Human1.25659293
74E2F1_20622854_ChIP-Seq_HELA_Human1.25182605
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24513744
76CTCF_27219007_Chip-Seq_Bcells_Human1.24027966
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23472968
78FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23323506
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22688704
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21084058
81GATA3_21867929_ChIP-Seq_TH1_Mouse1.20947363
82RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20495583
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.19056531
84ETV1_20927104_ChIP-Seq_GIST48_Human1.19001772
85VDR_24763502_ChIP-Seq_THP-1_Human1.18741676
86RACK7_27058665_Chip-Seq_MCF-7_Human1.16978517
87SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16967083
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16923860
89STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16418430
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16210338
91CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14951883
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14926177
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14330070
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.13738284
95* REST_21632747_ChIP-Seq_MESCs_Mouse1.12969881
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12570639
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11917987
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.11004338
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.09795703
100CEBPB_22108803_ChIP-Seq_LS180_Human1.09675512
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09152552
102* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09021005
103PHF8_20622853_ChIP-Seq_HELA_Human1.09000146
104HNFA_21074721_ChIP-Seq_CACO-2_Human1.08899022
105SOX2_20726797_ChIP-Seq_SW620_Human1.08045420
106CREB1_26743006_Chip-Seq_LNCaP_Human1.08045055
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.07155429
108CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06672734
109* GATA2_19941826_ChIP-Seq_K562_Human1.06394660
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06161796
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06161796
112EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06075995
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05249348
114GF1_26923725_Chip-Seq_HPCs_Mouse1.04760334
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04268070
116PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04221956
117* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04220790
118ESR1_21235772_ChIP-Seq_MCF-7_Human1.04139601
119MAF_26560356_Chip-Seq_TH1_Human1.03703941
120ERG_20517297_ChIP-Seq_VCAP_Human1.03596826
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03518103
122SPI1_20517297_ChIP-Seq_HL60_Human1.03510547
123RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03327775
124RBPJ_21746931_ChIP-Seq_IB4_Human1.03312148
125FOXA1_25552417_ChIP-Seq_VCAP_Human1.03101106
126YY1_22570637_ChIP-Seq_MALME-3M_Human1.02581916
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02056903
128E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01832936
129RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01634038
130SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01522362
131MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01500517
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01102652
133RARA_24833708_ChIP-Seq_LIVER_Mouse1.00511148
134SPI1_26923725_Chip-Seq_HPCs_Mouse1.00182006
135OCT4_18555785_Chip-Seq_ESCs_Mouse0.99698806
136ESET_19884257_ChIP-Seq_ESCs_Mouse0.99575984
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99460865
138CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99427040
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97422299
140GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97218634
141GATA6_21074721_ChIP-Seq_CACO-2_Human0.97023313
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96968692
143EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96824387
144* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96660791
145SA1_27219007_Chip-Seq_ERYTHROID_Human0.96627428
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95919944
147P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.95587017
148IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95458091
149RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95316243
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.95261035
151TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94954161
152CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94878117
153* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94476426
154OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94364561
155GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94013861
156* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93567777
157EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93565205
158EZH2_27294783_Chip-Seq_NPCs_Mouse0.92998098
159OCT4_20526341_ChIP-Seq_ESCs_Human0.92941358
160GATA4_25053715_ChIP-Seq_YYC3_Human0.92851396
161SOX2_21211035_ChIP-Seq_LN229_Human0.92547192
162P53_22387025_ChIP-Seq_ESCs_Mouse0.91934733
163CBX2_22325352_ChIP-Seq_293T-Rex_Human0.91738550
164RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91145847
165PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90818207
166FLI1_21867929_ChIP-Seq_CD8_Mouse0.90496062
167* IRF8_27001747_Chip-Seq_BMDM_Mouse0.90302386
168SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90264594
169GATA3_27048872_Chip-Seq_THYMUS_Human0.89772797
170PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89634275
171CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89056900
172KLF4_18555785_Chip-Seq_ESCs_Mouse0.88414901
173RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88154708
174RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88138043
175ELF1_20517297_ChIP-Seq_JURKAT_Human0.87816412
176P300_18555785_Chip-Seq_ESCs_Mouse0.87443335
177* MYC_27129775_Chip-Seq_CORNEA_Mouse0.86719122
178ESRRB_18555785_Chip-Seq_ESCs_Mouse0.86659460
179LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85914790
180NFYB_21822215_ChIP-Seq_K562_Human0.85504130
181NANOG_20526341_ChIP-Seq_ESCs_Human0.85168857
182CMYC_18555785_Chip-Seq_ESCs_Mouse0.84952823
183ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84937932
184PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83696003
185TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83270108
186NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82819335

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04957687
2MP0001929_abnormal_gametogenesis5.53832317
3MP0008877_abnormal_DNA_methylation4.30941708
4MP0002277_abnormal_respiratory_mucosa3.83994583
5MP0002210_abnormal_sex_determination3.61885804
6MP0002161_abnormal_fertility/fecundity3.28992413
7MP0002653_abnormal_ependyma_morphology3.21562134
8MP0001145_abnormal_male_reproductive3.07627560
9MP0008789_abnormal_olfactory_epithelium2.88972631
10MP0000653_abnormal_sex_gland2.66885359
11MP0005083_abnormal_biliary_tract2.57044498
12MP0009780_abnormal_chondrocyte_physiolo2.36871719
13MP0003303_peritoneal_inflammation2.33176835
14MP0000566_synostosis2.31529024
15MP0005670_abnormal_white_adipose2.28123004
16MP0005623_abnormal_meninges_morphology2.12621074
17MP0005410_abnormal_fertilization15.8742008
18MP0005394_taste/olfaction_phenotype1.94844774
19MP0005499_abnormal_olfactory_system1.94844774
20MP0003724_increased_susceptibility_to1.94011735
21MP0003656_abnormal_erythrocyte_physiolo1.90411470
22MP0002160_abnormal_reproductive_system1.84385892
23MP0002168_other_aberrant_phenotype1.74156947
24MP0000465_gastrointestinal_hemorrhage1.71396313
25MP0010155_abnormal_intestine_physiology1.64657101
26MP0002282_abnormal_trachea_morphology1.53779823
27MP0000383_abnormal_hair_follicle1.45828686
28MP0000678_abnormal_parathyroid_gland1.39649997
29MP0003646_muscle_fatigue1.35137471
30MP0005248_abnormal_Harderian_gland1.32559347
31MP0003136_yellow_coat_color1.32345856
32MP0004883_abnormal_blood_vessel1.25543461
33MP0010678_abnormal_skin_adnexa1.23169819
34MP0003436_decreased_susceptibility_to1.22821646
35MP0002909_abnormal_adrenal_gland1.20139935
36MP0001790_abnormal_immune_system1.19898103
37MP0005387_immune_system_phenotype1.19898103
38MP0005164_abnormal_response_to1.19744371
39MP0002139_abnormal_hepatobiliary_system1.19245345
40MP0005464_abnormal_platelet_physiology1.17704058
41MP0005025_abnormal_response_to1.15520302
42MP0004233_abnormal_muscle_weight1.15187699
43MP0005647_abnormal_sex_gland1.12842561
44MP0006082_CNS_inflammation1.11939331
45MP0005165_increased_susceptibility_to1.11362411
46MP0001835_abnormal_antigen_presentation1.09647851
47MP0008058_abnormal_DNA_repair1.09408103
48MP0002249_abnormal_larynx_morphology1.07897035
49MP0003866_abnormal_defecation1.02790214
50MP0001765_abnormal_ion_homeostasis1.01127072
51MP0005395_other_phenotype0.99970230
52MP0003011_delayed_dark_adaptation0.99578930
53MP0002419_abnormal_innate_immunity0.97756393
54MP0000858_altered_metastatic_potential0.97564535
55MP0009765_abnormal_xenobiotic_induced0.95400664
56MP0008004_abnormal_stomach_pH0.94707075
57MP0003191_abnormal_cellular_cholesterol0.92948155
58MP0005389_reproductive_system_phenotype0.91792408
59MP0005310_abnormal_salivary_gland0.91230317
60MP0008995_early_reproductive_senescence0.90706491
61MP0009046_muscle_twitch0.90257985
62MP0003075_altered_response_to0.89824345
63MP0001346_abnormal_lacrimal_gland0.87668064
64MP0009379_abnormal_foot_pigmentation0.86000316
65MP0005365_abnormal_bile_salt0.85893748
66MP0008057_abnormal_DNA_replication0.84923957
67MP0002734_abnormal_mechanical_nocicepti0.84771341
68MP0001849_ear_inflammation0.82015118
69MP0005360_urolithiasis0.81865566
70MP0009763_increased_sensitivity_to0.81020019
71MP0001485_abnormal_pinna_reflex0.80813157
72MP0001984_abnormal_olfaction0.80669615
73MP0010094_abnormal_chromosome_stability0.78872465
74MP0002735_abnormal_chemical_nociception0.78125992
75MP0003828_pulmonary_edema0.76564228
76MP0000358_abnormal_cell_content/0.76338090
77MP0001663_abnormal_digestive_system0.75298642
78MP0005409_darkened_coat_color0.74841336
79MP0002136_abnormal_kidney_physiology0.74659427
80MP0009643_abnormal_urine_homeostasis0.73579635
81MP0009785_altered_susceptibility_to0.73563651
82MP0008260_abnormal_autophagy0.71901731
83MP0008875_abnormal_xenobiotic_pharmacok0.71887787
84MP0003453_abnormal_keratinocyte_physiol0.71407217
85MP0001845_abnormal_inflammatory_respons0.70738624
86MP0005636_abnormal_mineral_homeostasis0.69825882
87MP0001533_abnormal_skeleton_physiology0.69295549
88MP0004264_abnormal_extraembryonic_tissu0.68434223
89MP0002638_abnormal_pupillary_reflex0.66557248
90MP0000681_abnormal_thyroid_gland0.66231867
91MP0005388_respiratory_system_phenotype0.63667864
92MP0002133_abnormal_respiratory_system0.63667864
93MP0000569_abnormal_digit_pigmentation0.61620188
94MP0001764_abnormal_homeostasis0.61495282
95MP0004019_abnormal_vitamin_homeostasis0.60977896
96MP0003115_abnormal_respiratory_system0.59118860
97MP0005166_decreased_susceptibility_to0.59001912
98MP0002928_abnormal_bile_duct0.58616770
99MP0002233_abnormal_nose_morphology0.58125949
100MP0005408_hypopigmentation0.57709901
101MP0008007_abnormal_cellular_replicative0.57700445
102MP0008873_increased_physiological_sensi0.56627788
103MP0003878_abnormal_ear_physiology0.56325288
104MP0005377_hearing/vestibular/ear_phenot0.56325288
105MP0002723_abnormal_immune_serum0.55666630
106MP0005085_abnormal_gallbladder_physiolo0.55621691
107MP0005397_hematopoietic_system_phenotyp0.54295331
108MP0001545_abnormal_hematopoietic_system0.54295331
109MP0003329_amyloid_beta_deposits0.53706546
110MP0002234_abnormal_pharynx_morphology0.53504197
111MP0001800_abnormal_humoral_immune0.53376193
112MP0000026_abnormal_inner_ear0.53154320
113MP0002452_abnormal_antigen_presenting0.52527306
114MP0003950_abnormal_plasma_membrane0.51064953
115MP0005666_abnormal_adipose_tissue0.50556750
116MP0001819_abnormal_immune_cell0.50428148
117MP0001664_abnormal_digestion0.50424887
118MP0003252_abnormal_bile_duct0.50195773
119MP0002148_abnormal_hypersensitivity_rea0.50146683
120MP0002420_abnormal_adaptive_immunity0.49822892
121MP0000685_abnormal_immune_system0.49311991
122MP0001324_abnormal_eye_pigmentation0.48659928
123MP0001293_anophthalmia0.47914817
124MP0006036_abnormal_mitochondrial_physio0.47241991
125MP0003699_abnormal_female_reproductive0.47222965
126MP0003786_premature_aging0.46672939
127MP0002971_abnormal_brown_adipose0.46110328
128MP0009278_abnormal_bone_marrow0.42947013
129MP0010329_abnormal_lipoprotein_level0.41932755
130MP0009115_abnormal_fat_cell0.40160562
131MP0002269_muscular_atrophy0.37481104
132MP0000604_amyloidosis0.37260193
133MP0001119_abnormal_female_reproductive0.37080483
134MP0003111_abnormal_nucleus_morphology0.35353792
135MP0010307_abnormal_tumor_latency0.35087460
136MP0005319_abnormal_enzyme/_coenzyme0.34436145
137MP0004808_abnormal_hematopoietic_stem0.33821967
138MP0002118_abnormal_lipid_homeostasis0.33588776
139MP0004036_abnormal_muscle_relaxation0.33345224
140MP0005551_abnormal_eye_electrophysiolog0.30858613
141MP0005391_vision/eye_phenotype0.30048231
142MP0005253_abnormal_eye_physiology0.28757452
143MP0006035_abnormal_mitochondrial_morpho0.27787116
144MP0001661_extended_life_span0.27544644
145MP0003633_abnormal_nervous_system0.26568049
146MP0001730_embryonic_growth_arrest0.26417471
147MP0000609_abnormal_liver_physiology0.25446683
148MP0002092_abnormal_eye_morphology0.24199725
149MP0004043_abnormal_pH_regulation0.24030314
150MP0000313_abnormal_cell_death0.22822178
151MP0002405_respiratory_system_inflammati0.21431698
152MP0005584_abnormal_enzyme/coenzyme_acti0.21366537
153MP0004133_heterotaxia0.19791718
154MP0003806_abnormal_nucleotide_metabolis0.19668229
155MP0002970_abnormal_white_adipose0.18042997
156MP0005332_abnormal_amino_acid0.17965854
157MP0003631_nervous_system_phenotype0.17892874
158MP0003879_abnormal_hair_cell0.17726547
159MP0004134_abnormal_chest_morphology0.17682263
160MP0008961_abnormal_basal_metabolism0.17214459
161MP0001727_abnormal_embryo_implantation0.17019649
162MP0003942_abnormal_urinary_system0.16563425
163MP0004811_abnormal_neuron_physiology0.16350843
164MP0003861_abnormal_nervous_system0.15160426
165MP0002152_abnormal_brain_morphology0.14915648
166MP0002102_abnormal_ear_morphology0.14641796
167MP0002132_abnormal_respiratory_system0.14489907
168MP0000598_abnormal_liver_morphology0.14364993
169MP0005535_abnormal_body_temperature0.14250773
170MP0002796_impaired_skin_barrier0.14235368
171MP0009642_abnormal_blood_homeostasis0.14137973
172MP0001851_eye_inflammation0.13694873
173MP0004130_abnormal_muscle_cell0.13598497
174MP0002295_abnormal_pulmonary_circulatio0.13302099

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.44452224
2Abnormal respiratory motile cilium morphology (HP:0005938)9.12881952
3Abnormal respiratory epithelium morphology (HP:0012253)9.12881952
4Rhinitis (HP:0012384)8.12394804
5Abnormal ciliary motility (HP:0012262)7.53289719
6Chronic bronchitis (HP:0004469)7.31867342
7Nasal polyposis (HP:0100582)6.69278150
8Infertility (HP:0000789)6.67084557
9Abnormality of the nasal mucosa (HP:0000433)5.51526772
10Bronchiectasis (HP:0002110)4.80955487
11Bronchitis (HP:0012387)4.76085605
12Nephronophthisis (HP:0000090)4.46424602
13Occipital encephalocele (HP:0002085)3.64374310
14Recurrent otitis media (HP:0000403)3.49944845
15Male infertility (HP:0003251)3.49551118
16Abnormality of the renal medulla (HP:0100957)3.42269967
17True hermaphroditism (HP:0010459)3.42221390
18Recurrent sinusitis (HP:0011108)3.37404746
19Chronic otitis media (HP:0000389)3.18297206
20Atelectasis (HP:0100750)3.14803458
21Tubulointerstitial nephritis (HP:0001970)3.10371479
22Recurrent bronchitis (HP:0002837)3.05564447
23Gonadotropin excess (HP:0000837)3.01784544
24Abnormal spermatogenesis (HP:0008669)2.96571374
25Impulsivity (HP:0100710)2.70997714
26Hyperactive renin-angiotensin system (HP:0000841)2.70934137
27Pancreatic cysts (HP:0001737)2.70792436
28Chronic hepatic failure (HP:0100626)2.59274712
29Abnormality of the lower motor neuron (HP:0002366)2.48945825
30Tubular atrophy (HP:0000092)2.43072477
31Tubulointerstitial abnormality (HP:0001969)2.41841069
32Abnormality of midbrain morphology (HP:0002418)2.40415338
33Molar tooth sign on MRI (HP:0002419)2.40415338
34Medial flaring of the eyebrow (HP:0010747)2.29428758
35Cholecystitis (HP:0001082)2.22235426
36Abnormal gallbladder physiology (HP:0012438)2.22235426
37Azoospermia (HP:0000027)2.20853059
38Spastic tetraparesis (HP:0001285)2.14728402
39Postaxial foot polydactyly (HP:0001830)2.05371608
40Fibular hypoplasia (HP:0003038)2.00371053
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7240737
42Dynein arm defect of respiratory motile cilia (HP:0012255)12.8741644
43Absent/shortened dynein arms (HP:0200106)12.8741644
44Anencephaly (HP:0002323)1.96194106
45Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94837750
46Amyotrophic lateral sclerosis (HP:0007354)1.91728597
47Stage 5 chronic kidney disease (HP:0003774)1.91601549
48Male pseudohermaphroditism (HP:0000037)1.89737499
49Congenital hepatic fibrosis (HP:0002612)1.81724461
50Abnormality of the renal cortex (HP:0011035)1.79467519
51J-shaped sella turcica (HP:0002680)1.77108912
52Bile duct proliferation (HP:0001408)1.76819872
53Abnormal biliary tract physiology (HP:0012439)1.76819872
54Tubulointerstitial fibrosis (HP:0005576)1.76625764
55Short ribs (HP:0000773)1.75909446
56Absent frontal sinuses (HP:0002688)1.74709141
57Heterotopia (HP:0002282)1.74241797
58Abnormality of dentin (HP:0010299)1.70207699
59Abnormality of permanent molar morphology (HP:0011071)1.69774202
60Abnormality of the dental root (HP:0006486)1.69774202
61Taurodontia (HP:0000679)1.69774202
62Microglossia (HP:0000171)1.69484698
63Bell-shaped thorax (HP:0001591)1.67871236
64Chronic sinusitis (HP:0011109)1.64458609
65Impaired proprioception (HP:0010831)1.63707698
66Renal salt wasting (HP:0000127)1.62633816
67Oculomotor apraxia (HP:0000657)1.62140409
68Renal dysplasia (HP:0000110)1.62099366
69Abnormality of molar (HP:0011077)1.58643333
70Abnormality of molar morphology (HP:0011070)1.58643333
71Polydipsia (HP:0001959)1.58349254
72Abnormal drinking behavior (HP:0030082)1.58349254
73Decreased circulating renin level (HP:0003351)1.57750874
74Furrowed tongue (HP:0000221)1.57429645
75Sclerocornea (HP:0000647)1.56574787
76Abnormality of the dental pulp (HP:0006479)1.55798594
77Abnormality of renal excretion (HP:0011036)1.53038499
78Nephrogenic diabetes insipidus (HP:0009806)1.52421399
79Dyschromatopsia (HP:0007641)1.51905762
80Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.51195750
81Absent epiphyses (HP:0010577)1.51195750
82Asplenia (HP:0001746)1.50556966
83Aplasia/Hypoplasia of the spleen (HP:0010451)1.49820362
84Deformed sella turcica (HP:0002681)1.49678330
85Absent rod-and cone-mediated responses on ERG (HP:0007688)1.45939371
86Postaxial hand polydactyly (HP:0001162)1.45853392
87Hyperkalemia (HP:0002153)1.43134191
88Cystic liver disease (HP:0006706)1.42956810
89Upper motor neuron abnormality (HP:0002127)1.42838419
90Facial cleft (HP:0002006)1.42696958
91Asymmetric septal hypertrophy (HP:0001670)1.41609631
92Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.40047406
93Supernumerary spleens (HP:0009799)1.39203583
94Short thorax (HP:0010306)1.37615961
95Decreased central vision (HP:0007663)1.37255467
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.34908810
97Nephropathy (HP:0000112)1.33014370
98Hemorrhage of the eye (HP:0011885)1.31479805
99Short nail (HP:0001799)1.30909312
100Vascular calcification (HP:0004934)1.29861022
101Choroideremia (HP:0001139)1.29365278
102Broad distal phalanx of finger (HP:0009836)1.29141994
103Congenital primary aphakia (HP:0007707)1.27984432
104Neurofibrillary tangles (HP:0002185)1.27398173
105Gait imbalance (HP:0002141)1.26302933
106Median cleft lip (HP:0000161)1.25343584
107Hemiparesis (HP:0001269)1.23954435
108Hyperaldosteronism (HP:0000859)1.23924301
109Pancreatic fibrosis (HP:0100732)1.23403677
110Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.23383369
111Pachygyria (HP:0001302)1.22198257
112Loss of speech (HP:0002371)1.21823522
113Poor coordination (HP:0002370)1.21608358
114Abnormality of chloride homeostasis (HP:0011422)1.20129492
115Aplasia/Hypoplasia of the lens (HP:0008063)1.20110012
116Cerebellar dysplasia (HP:0007033)1.19657063
117Preaxial hand polydactyly (HP:0001177)1.19114836
118Short femoral neck (HP:0100864)1.18669120
119Hypercholesterolemia (HP:0003124)1.18360775
120Aplasia/Hypoplasia of the fibula (HP:0006492)1.17580063
121Abnormal urine output (HP:0012590)1.17050694
122Recurrent gram-negative bacterial infections (HP:0005420)1.16964213
123Abnormality of renin-angiotensin system (HP:0000847)1.16760712
124Muscle fiber splitting (HP:0003555)1.16116202
125Cone-rod dystrophy (HP:0000548)1.15938127
126Cardiovascular calcification (HP:0011915)1.15370928
127Abnormality of the anterior horn cell (HP:0006802)1.15321689
128Abnormality of the distal phalanges of the toes (HP:0010182)1.15292359
129Vaginal atresia (HP:0000148)1.13277759
130Genital tract atresia (HP:0001827)1.12729722
131Fetal akinesia sequence (HP:0001989)1.11328462
132Abnormality of the frontal sinuses (HP:0002687)1.09277053
133Aplasia of the musculature (HP:0100854)1.09145333
134Recurrent abscess formation (HP:0002722)1.08907809
135Hyponatremia (HP:0002902)1.07640893
136Recurrent bacterial skin infections (HP:0005406)1.07000539
137Hypokalemic alkalosis (HP:0001949)1.05540862
138Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.04650651
139Elevated erythrocyte sedimentation rate (HP:0003565)1.04493322
140Glucose intolerance (HP:0000833)1.02374394
141Abnormal rod and cone electroretinograms (HP:0008323)1.00345444
142Hand muscle atrophy (HP:0009130)1.00333675
143Bifid scrotum (HP:0000048)0.98291871
144Popliteal pterygium (HP:0009756)0.97366060
145Retinitis pigmentosa (HP:0000510)0.96905326
146Myositis (HP:0100614)0.96666483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.71244113
2PDK38.71244113
3PDK25.63422078
4TESK15.53888083
5MST44.33183021
6PRKD34.09992099
7ICK3.69633340
8EPHA23.66295516
9WNK42.45343202
10PNCK2.42947349
11MAP3K22.35998728
12STK392.23305024
13PTK2B2.21964171
14MAP3K31.99749994
15NEK21.83552130
16MAPKAPK31.74110636
17STK241.66315145
18NME11.63459633
19SMG11.55194908
20GRK61.52372596
21STK381.48777841
22DYRK1B1.48095621
23LRRK21.35533843
24MAPK151.25190406
25BLK1.10363110
26EPHA31.07476451
27TLK11.07419444
28TBK11.06614856
29WNK11.03438999
30PDK10.98705755
31MAP2K30.93254659
32PASK0.91083948
33MAP3K70.88839399
34CCNB10.88809363
35BCR0.88100010
36TYRO30.87421229
37MAP3K120.86398671
38IRAK10.84790722
39STK30.84288233
40DYRK30.83566951
41TYK20.81634512
42IRAK40.81353470
43MAP3K110.74108644
44MAP2K40.71459918
45STK160.68322953
46WEE10.62734223
47CAMK1G0.61326135
48TRPM70.60855356
49BTK0.60276017
50MST1R0.59532242
51PINK10.57639380
52LMTK20.56745603
53TTK0.56150552
54BMPR1B0.56080362
55TNK20.54980838
56MAP3K60.53888736
57PRKCI0.53709345
58PRKCD0.49874920
59TESK20.49265058
60CDK190.49162662
61EEF2K0.48102993
62KSR20.46947147
63HCK0.46061556
64CHEK20.45696061
65PDPK10.45685324
66MAP2K60.45045797
67ERBB20.43538630
68CHEK10.43155316
69CDC70.41687210
70PTK60.41404333
71FES0.40614328
72IRAK20.40303768
73LYN0.40120751
74AURKA0.39854057
75MATK0.39577029
76PLK40.38739314
77ATR0.38121105
78MAP3K10.38055836
79RIPK40.34794811
80IKBKE0.34609301
81FYN0.34330933
82ADRBK10.34068885
83ERBB30.33847483
84MTOR0.33417772
85RET0.32373897
86SGK10.32027650
87ATM0.31527243
88FGR0.31514412
89PAK10.31043834
90PAK20.28710102
91MAP2K70.26492921
92NTRK20.25845940
93CAMKK10.25624035
94HIPK20.25432268
95STK38L0.24870169
96MUSK0.24691198
97PRKD20.22805295
98CDC42BPA0.21716231
99JAK20.21579578
100PRKCG0.21261278
101BMPR20.21224169
102ABL10.21167923
103DYRK1A0.20510606
104MAPKAPK50.20414109
105PRKAA20.20403199
106RPS6KB10.20316465
107ARAF0.20296258
108PRKAA10.20290129
109NLK0.20110832
110PLK10.19906363
111MAP2K20.18451006
112NEK60.17938960
113MYLK0.17884688
114CAMK2G0.17117130
115BRSK20.16782711
116PRKACA0.16479150
117FGFR30.16412123
118MARK20.16197235
119SRC0.16045702
120MAP3K40.15916437
121PRKD10.15048217
122RPS6KA20.14716703
123CDK120.13910360
124PAK40.12716436
125PRKCQ0.11314315
126PRKCZ0.10828877
127MAP3K100.10261723
128ZAP700.09542967
129TRIB30.08987551
130ERN10.06411414
131CSNK2A10.06237733
132MARK30.06071053
133CSF1R0.05334877
134PRKACG0.05206554
135WNK30.04959453
136RPS6KA10.04729683
137CDK60.03864967
138CSNK1D0.03703077
139GSK3B0.03312961
140YES10.03234145
141EGFR0.03174619
142CDK10.02652923
143PRKG10.02202767
144CDK20.01906554
145PRKACB0.01852691
146CDK150.01813378
147CSK0.01750337
148BRSK10.01598447
149PIM10.01308469
150CSNK2A20.01208830
151MAP3K50.01160612
152BRAF0.01120498
153PDGFRB0.00296364
154STK100.00018726
155PRKCA-0.0295512
156CDK3-0.0292695
157STK11-0.0267013
158RPS6KA3-0.0257588
159EPHB1-0.0216839
160PRKCB-0.0183751
161TAOK1-0.0177267
162PRKDC-0.0147533
163CDK11A-0.0090749
164PRKG2-0.0080034
165CDK18-0.0068789
166MAPK8-0.0062135
167CDK4-0.0049712

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.32471992
2Pyruvate metabolism_Homo sapiens_hsa006203.95365287
3Vitamin B6 metabolism_Homo sapiens_hsa007503.69739811
4Tyrosine metabolism_Homo sapiens_hsa003503.67878083
5Fatty acid biosynthesis_Homo sapiens_hsa000613.50512380
6Propanoate metabolism_Homo sapiens_hsa006403.13429118
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.74134448
8Selenocompound metabolism_Homo sapiens_hsa004502.72367167
9Glucagon signaling pathway_Homo sapiens_hsa049222.63754768
10Linoleic acid metabolism_Homo sapiens_hsa005912.60470414
11beta-Alanine metabolism_Homo sapiens_hsa004102.52859177
12Dorso-ventral axis formation_Homo sapiens_hsa043202.45117110
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.17791789
14Basal transcription factors_Homo sapiens_hsa030222.17774788
15PPAR signaling pathway_Homo sapiens_hsa033202.16256881
16Pentose phosphate pathway_Homo sapiens_hsa000302.12713422
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.07394523
18Glycerolipid metabolism_Homo sapiens_hsa005612.05961852
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.96805505
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.87791040
21Fanconi anemia pathway_Homo sapiens_hsa034601.72409143
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70561405
23Fatty acid degradation_Homo sapiens_hsa000711.69301772
24Oocyte meiosis_Homo sapiens_hsa041141.67370410
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67271380
26Huntingtons disease_Homo sapiens_hsa050161.63030338
27Carbon metabolism_Homo sapiens_hsa012001.59839662
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.59563569
29Caffeine metabolism_Homo sapiens_hsa002321.58874010
30Fructose and mannose metabolism_Homo sapiens_hsa000511.58652582
31Fatty acid metabolism_Homo sapiens_hsa012121.55552453
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.50913320
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.48528399
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.45686672
35Fat digestion and absorption_Homo sapiens_hsa049751.43296459
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42668047
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.37249896
38Sphingolipid metabolism_Homo sapiens_hsa006001.33302900
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29408746
40Amphetamine addiction_Homo sapiens_hsa050311.22710400
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22405078
42Chemical carcinogenesis_Homo sapiens_hsa052041.17986641
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17302365
44Ether lipid metabolism_Homo sapiens_hsa005651.13167255
45Biosynthesis of amino acids_Homo sapiens_hsa012301.10044479
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.09268518
47Hematopoietic cell lineage_Homo sapiens_hsa046401.07583055
48Antigen processing and presentation_Homo sapiens_hsa046121.06391005
49Glutathione metabolism_Homo sapiens_hsa004801.05797562
50mRNA surveillance pathway_Homo sapiens_hsa030151.05683740
51ABC transporters_Homo sapiens_hsa020101.05673421
52Notch signaling pathway_Homo sapiens_hsa043301.04367844
53Cardiac muscle contraction_Homo sapiens_hsa042601.03019376
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00237164
55Mineral absorption_Homo sapiens_hsa049781.00132793
56Tight junction_Homo sapiens_hsa045300.99622285
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98351873
58Staphylococcus aureus infection_Homo sapiens_hsa051500.91245614
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90841962
60Phagosome_Homo sapiens_hsa041450.90813668
61Renin secretion_Homo sapiens_hsa049240.90588429
62Hepatitis C_Homo sapiens_hsa051600.90213774
63Purine metabolism_Homo sapiens_hsa002300.89241178
64RNA transport_Homo sapiens_hsa030130.88483017
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87737867
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86825053
67Bile secretion_Homo sapiens_hsa049760.83458811
68Salivary secretion_Homo sapiens_hsa049700.83014112
69Choline metabolism in cancer_Homo sapiens_hsa052310.80081449
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.77614305
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74974950
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.73466193
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72213277
74Leishmaniasis_Homo sapiens_hsa051400.71660310
75Olfactory transduction_Homo sapiens_hsa047400.71396194
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66803781
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66569101
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.66404184
79Osteoclast differentiation_Homo sapiens_hsa043800.63825506
80Complement and coagulation cascades_Homo sapiens_hsa046100.62897864
81Tuberculosis_Homo sapiens_hsa051520.62190523
82Circadian rhythm_Homo sapiens_hsa047100.61094146
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60649817
84Starch and sucrose metabolism_Homo sapiens_hsa005000.60637265
85Allograft rejection_Homo sapiens_hsa053300.59926886
86Arachidonic acid metabolism_Homo sapiens_hsa005900.59926618
87Legionellosis_Homo sapiens_hsa051340.59585177
88Taste transduction_Homo sapiens_hsa047420.58886849
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58632642
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58560494
91Malaria_Homo sapiens_hsa051440.57988223
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.57452633
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.57203228
94Graft-versus-host disease_Homo sapiens_hsa053320.57166408
95Retinol metabolism_Homo sapiens_hsa008300.56756642
96Autoimmune thyroid disease_Homo sapiens_hsa053200.55894560
97Regulation of autophagy_Homo sapiens_hsa041400.55312129
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51031852
99Sulfur metabolism_Homo sapiens_hsa009200.50661108
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50658403
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50476522
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50325493
103Systemic lupus erythematosus_Homo sapiens_hsa053220.48950666
104Hedgehog signaling pathway_Homo sapiens_hsa043400.48932354
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48838540
106Estrogen signaling pathway_Homo sapiens_hsa049150.48189944
107AMPK signaling pathway_Homo sapiens_hsa041520.47676480
108Salmonella infection_Homo sapiens_hsa051320.47433816
109Metabolic pathways_Homo sapiens_hsa011000.47110613
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47082056
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46456809
112Collecting duct acid secretion_Homo sapiens_hsa049660.44852997
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44654767
114Peroxisome_Homo sapiens_hsa041460.44335025
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.43479897
116Amoebiasis_Homo sapiens_hsa051460.43092990
117Type I diabetes mellitus_Homo sapiens_hsa049400.42558167
118Thyroid hormone synthesis_Homo sapiens_hsa049180.42389541
119Chemokine signaling pathway_Homo sapiens_hsa040620.41181655
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41116806
121Long-term potentiation_Homo sapiens_hsa047200.41044825
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40273386
123Influenza A_Homo sapiens_hsa051640.39560153
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39028055
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38282538
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.37651295
127N-Glycan biosynthesis_Homo sapiens_hsa005100.36894513
128Insulin secretion_Homo sapiens_hsa049110.36605079
129Cocaine addiction_Homo sapiens_hsa050300.36428667
130Apoptosis_Homo sapiens_hsa042100.35857178
131Lysosome_Homo sapiens_hsa041420.35765487
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33683033
133Renin-angiotensin system_Homo sapiens_hsa046140.33669104
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33397133
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32665168
136Inositol phosphate metabolism_Homo sapiens_hsa005620.32600329
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31204571
138Calcium signaling pathway_Homo sapiens_hsa040200.31072313
139B cell receptor signaling pathway_Homo sapiens_hsa046620.30846134
140Endocytosis_Homo sapiens_hsa041440.30440615
141Adherens junction_Homo sapiens_hsa045200.30008785
142cAMP signaling pathway_Homo sapiens_hsa040240.29796916
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27358933
144Pyrimidine metabolism_Homo sapiens_hsa002400.26968524
145Serotonergic synapse_Homo sapiens_hsa047260.26830322
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25213111
147Pancreatic cancer_Homo sapiens_hsa052120.23339500
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21993794
149Tryptophan metabolism_Homo sapiens_hsa003800.21527154
150VEGF signaling pathway_Homo sapiens_hsa043700.21507362
151Toxoplasmosis_Homo sapiens_hsa051450.20856723
152Measles_Homo sapiens_hsa051620.19739616
153Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19511419
154Protein digestion and absorption_Homo sapiens_hsa049740.19438374
155Gap junction_Homo sapiens_hsa045400.18284942
156Vitamin digestion and absorption_Homo sapiens_hsa049770.15905013
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14381168
158Pancreatic secretion_Homo sapiens_hsa049720.14149543
159Nitrogen metabolism_Homo sapiens_hsa009100.13099808
160RNA degradation_Homo sapiens_hsa030180.13053660
161Insulin resistance_Homo sapiens_hsa049310.11302157
162Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.09326419
163Vascular smooth muscle contraction_Homo sapiens_hsa042700.08592954
164Phenylalanine metabolism_Homo sapiens_hsa003600.08454189
165Histidine metabolism_Homo sapiens_hsa003400.07992953

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