ROR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)6.21404873
2regulation of posttranscriptional gene silencing (GO:0060147)5.43174294
3regulation of gene silencing by miRNA (GO:0060964)5.43174294
4regulation of gene silencing by RNA (GO:0060966)5.43174294
5lateral sprouting from an epithelium (GO:0060601)4.96570484
6establishment of integrated proviral latency (GO:0075713)4.11339265
7regulation of non-canonical Wnt signaling pathway (GO:2000050)4.01663538
8paraxial mesoderm development (GO:0048339)3.91902545
9negative regulation of cardiac muscle tissue development (GO:0055026)3.91445214
10planar cell polarity pathway involved in neural tube closure (GO:0090179)3.78227356
11regulation of mitotic spindle checkpoint (GO:1903504)3.77948604
12regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.77948604
13insulin-like growth factor receptor signaling pathway (GO:0048009)3.74808371
14collagen fibril organization (GO:0030199)3.70968591
15cardiac myofibril assembly (GO:0055003)3.70886328
16G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.67372232
17pre-miRNA processing (GO:0031054)3.66354798
18lung-associated mesenchyme development (GO:0060484)3.63749959
19chaperone-mediated protein complex assembly (GO:0051131)3.63554030
20hippo signaling (GO:0035329)3.59388439
21L-serine metabolic process (GO:0006563)3.51451375
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.48986866
23negative regulation of cardiac muscle tissue growth (GO:0055022)3.47410506
24negative regulation of heart growth (GO:0061117)3.47410506
25positive regulation of SMAD protein import into nucleus (GO:0060391)3.45720080
26chondrocyte proliferation (GO:0035988)3.44978490
27heterochromatin organization (GO:0070828)3.44175732
28chromatin remodeling at centromere (GO:0031055)3.43094701
29negative regulation of chondrocyte differentiation (GO:0032331)3.42401881
30anterior/posterior axis specification, embryo (GO:0008595)3.41891942
31endocardial cushion morphogenesis (GO:0003203)3.41633952
32mesenchyme morphogenesis (GO:0072132)3.33961579
33somite development (GO:0061053)3.30190629
34protein heterotrimerization (GO:0070208)3.29957223
35outer ear morphogenesis (GO:0042473)3.28329551
36protein localization to kinetochore (GO:0034501)3.25151026
37notochord development (GO:0030903)3.23717759
38dorsal/ventral axis specification (GO:0009950)3.23376539
39CENP-A containing nucleosome assembly (GO:0034080)3.21878202
40negative regulation of catenin import into nucleus (GO:0035414)3.20165247
41bone trabecula formation (GO:0060346)3.17371582
42sequestering of extracellular ligand from receptor (GO:0035581)3.15869225
43regulation of heart morphogenesis (GO:2000826)3.15707478
44lung vasculature development (GO:0060426)3.12306179
45metanephric mesenchyme development (GO:0072075)3.12173129
46regulation of cardiac muscle cell proliferation (GO:0060043)3.12143511
47bundle of His cell to Purkinje myocyte communication (GO:0086069)3.11718765
48cell migration involved in sprouting angiogenesis (GO:0002042)3.10499353
49outflow tract septum morphogenesis (GO:0003148)3.10062043
50pituitary gland development (GO:0021983)3.09208176
51negative regulation of fatty acid transport (GO:2000192)3.07454468
52regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.06674153
53axon extension involved in axon guidance (GO:0048846)3.05892538
54neuron projection extension involved in neuron projection guidance (GO:1902284)3.05892538
55cellular response to osmotic stress (GO:0071470)3.01585741
56exocrine pancreas development (GO:0031017)3.01016313
57epithelial cell-cell adhesion (GO:0090136)3.00994636
58organ induction (GO:0001759)3.00417779
59polarized epithelial cell differentiation (GO:0030859)2.98217348
60regulation of catenin import into nucleus (GO:0035412)2.97698384
61kidney mesenchyme development (GO:0072074)2.97172266
62regulation of helicase activity (GO:0051095)2.96849192
63positive regulation of mesenchymal cell proliferation (GO:0002053)2.96440742
64cell proliferation involved in metanephros development (GO:0072203)2.94135110
65cell migration involved in heart development (GO:0060973)2.93636163
66negative regulation of keratinocyte proliferation (GO:0010839)2.93292403
67myofibril assembly (GO:0030239)2.92470160
68convergent extension (GO:0060026)2.92149138
69otic vesicle formation (GO:0030916)2.92003966
70negative regulation of androgen receptor signaling pathway (GO:0060766)2.91527727
71negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.90806732
72female gonad development (GO:0008585)2.90730262
73lymph vessel development (GO:0001945)2.90211646
74regulation of cell fate specification (GO:0042659)2.88420582
75regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.88031770
76establishment of viral latency (GO:0019043)2.87753066
77aorta morphogenesis (GO:0035909)2.85781106
78desmosome organization (GO:0002934)2.85750539
79histone exchange (GO:0043486)2.85179224
80cardiac muscle cell proliferation (GO:0060038)2.84914275
81mitotic metaphase plate congression (GO:0007080)2.84874096
82atrial septum morphogenesis (GO:0060413)2.84824001
83positive regulation of fatty acid beta-oxidation (GO:0032000)2.84678191
84negative regulation of cartilage development (GO:0061037)2.83834787
85establishment of apical/basal cell polarity (GO:0035089)2.83429194
86basement membrane organization (GO:0071711)2.83139633
87branching involved in salivary gland morphogenesis (GO:0060445)2.82437541
88regulation of mesoderm development (GO:2000380)2.81494976
89endocardial cushion development (GO:0003197)2.80616196
90regulation of cardiac muscle tissue development (GO:0055024)2.79441344
91kidney morphogenesis (GO:0060993)2.78958226
92skin morphogenesis (GO:0043589)2.78842063
93morphogenesis of an epithelial sheet (GO:0002011)2.78583768
94mesenchyme development (GO:0060485)2.78310458
95extracellular matrix assembly (GO:0085029)2.77991593
96protein complex localization (GO:0031503)2.77902651
97endodermal cell differentiation (GO:0035987)2.76935645
98positive regulation of hormone biosynthetic process (GO:0046886)2.76932761
99gap junction assembly (GO:0016264)2.76210657
100regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.75896804
101regulation of cardiac muscle tissue growth (GO:0055021)2.75716832
102positive regulation of catenin import into nucleus (GO:0035413)2.75707348
103trabecula formation (GO:0060343)2.75305543
104Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.74752698
105retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74058799
106middle ear morphogenesis (GO:0042474)2.74033747
107negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73957584
108negative regulation of translation, ncRNA-mediated (GO:0040033)2.73957584
109regulation of translation, ncRNA-mediated (GO:0045974)2.73957584
110negative regulation of DNA-dependent DNA replication (GO:2000104)2.73883432
111plasma membrane repair (GO:0001778)2.73592132
112regulation of cardioblast differentiation (GO:0051890)2.73428511
113regulation of mesenchymal cell proliferation (GO:0010464)2.73371854
114epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.73347353
115regulation of transforming growth factor beta2 production (GO:0032909)2.72716239
116hemidesmosome assembly (GO:0031581)2.72551581
117IMP biosynthetic process (GO:0006188)2.71290690
118negative regulation of mitotic sister chromatid separation (GO:2000816)2.71086670
119negative regulation of sister chromatid segregation (GO:0033046)2.71086670
120negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.71086670
121negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.71086670
122negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71086670
123heart morphogenesis (GO:0003007)2.70731780
124negative regulation of cell fate specification (GO:0009996)2.70604710
125glomerular basement membrane development (GO:0032836)2.70504647
126water-soluble vitamin biosynthetic process (GO:0042364)2.69179480
127heart trabecula formation (GO:0060347)2.68924336
128regulation of cell fate commitment (GO:0010453)2.68451551
129nuclear pore complex assembly (GO:0051292)2.68296778
130positive regulation of glycogen biosynthetic process (GO:0045725)2.68125316
131negative regulation of chromosome segregation (GO:0051985)2.67562071
132non-canonical Wnt signaling pathway (GO:0035567)2.67128912
133regulation of DNA endoreduplication (GO:0032875)2.66675811
134gastrulation with mouth forming second (GO:0001702)2.65582836
135renal filtration (GO:0097205)2.64462930
136mesenchymal to epithelial transition (GO:0060231)2.63964555
137inner ear receptor cell development (GO:0060119)2.63838511
138regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.63336106
139cell proliferation involved in kidney development (GO:0072111)2.63190136
140cardiac cell development (GO:0055006)2.62494632
141cardiac epithelial to mesenchymal transition (GO:0060317)2.61504480
142regulation of establishment of planar polarity (GO:0090175)2.61453037
143regulation of histone H3-K9 methylation (GO:0051570)2.61102610
144regulation of tight junction assembly (GO:2000810)2.60481208
145endothelial cell morphogenesis (GO:0001886)2.59552305
146ventricular cardiac muscle cell development (GO:0055015)2.59403184
147L-alpha-amino acid transmembrane transport (GO:1902475)2.59374528
148response to X-ray (GO:0010165)2.59239446
149cell fate commitment involved in formation of primary germ layer (GO:0060795)2.58694644
150glomerulus development (GO:0032835)2.58375820
151negative regulation of organ growth (GO:0046621)2.58082038
152regulation of gene silencing (GO:0060968)2.57357999
153nodal signaling pathway (GO:0038092)2.57254703
154midgut development (GO:0007494)2.56770330
155sarcomere organization (GO:0045214)2.56703995
156DNA replication-independent nucleosome assembly (GO:0006336)2.56322614
157DNA replication-independent nucleosome organization (GO:0034724)2.56322614
158lactate metabolic process (GO:0006089)2.56018153
159prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.54861027
160IMP metabolic process (GO:0046040)2.54725772
161craniofacial suture morphogenesis (GO:0097094)2.54716679
162collagen metabolic process (GO:0032963)2.54052938
163cardiac muscle cell development (GO:0055013)2.53755769
164DNA strand elongation involved in DNA replication (GO:0006271)2.53659949
165lung epithelium development (GO:0060428)2.52734098
166neural crest cell development (GO:0014032)2.52654963
167DNA replication checkpoint (GO:0000076)2.52147761
168mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.51509914
169mesodermal cell differentiation (GO:0048333)2.51314000
170glomerular filtration (GO:0003094)2.50615193
171negative regulation of potassium ion transmembrane transport (GO:1901380)2.49381595
172negative regulation of telomerase activity (GO:0051974)2.49044070
173RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48891764
174tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48891764
175telomere maintenance via telomerase (GO:0007004)2.48772363
176cell surface receptor signaling pathway involved in heart development (GO:0061311)2.48707961
177mesenchymal cell proliferation (GO:0010463)2.47620395
178metaphase plate congression (GO:0051310)2.47419742
179regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.47034597
180regulation of mitotic metaphase/anaphase transition (GO:0030071)2.47034597
181regulation of gastrulation (GO:0010470)2.46915941
182cellular response to BMP stimulus (GO:0071773)2.46598382
183response to BMP (GO:0071772)2.46598382
184DNA strand elongation (GO:0022616)2.46543272
185body morphogenesis (GO:0010171)2.46505904
186regulation of sister chromatid segregation (GO:0033045)2.45260018
187regulation of mitotic sister chromatid segregation (GO:0033047)2.45260018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.65129356
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.11556933
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.58576783
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.24346201
5CLOCK_20551151_ChIP-Seq_293T_Human2.89484908
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.82815613
7* EP300_21415370_ChIP-Seq_HL-1_Mouse2.77680421
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66019524
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64701936
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.62930860
11* NANOG_16153702_ChIP-ChIP_HESCs_Human2.60759531
12* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.54671121
13* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.53695475
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.42551098
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.25724845
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.24075139
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.24075139
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.24075139
19* SOX2_16153702_ChIP-ChIP_HESCs_Human2.17929353
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.17722263
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16792904
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.15459202
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.14300053
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.13547012
25WT1_19549856_ChIP-ChIP_CCG9911_Human2.13531999
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.13196316
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08866594
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02687337
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.01388321
30ESR1_20079471_ChIP-ChIP_T-47D_Human2.00525351
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00310836
32* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.00101794
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99373877
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97609921
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97082536
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.93659397
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.93428994
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90987726
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89818708
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.88548030
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87748490
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85966069
43* CJUN_26792858_Chip-Seq_BT549_Human1.83961418
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82821986
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77888867
46FUS_26573619_Chip-Seq_HEK293_Human1.77677292
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.75690600
48ISL1_27105846_Chip-Seq_CPCs_Mouse1.75638176
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.75026603
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74712780
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.70737738
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.67867978
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.67867978
54* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.67476698
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.66440076
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.64451358
57BRD4_25478319_ChIP-Seq_HGPS_Human1.64334108
58* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63915136
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63515957
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63396922
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63396922
62SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.62800672
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57690314
64TBX20_22080862_ChIP-Seq_HEART_Mouse1.57367371
65TBX20_22328084_ChIP-Seq_HEART_Mouse1.57367371
66RXR_22158963_ChIP-Seq_LIVER_Mouse1.56501754
67LXR_22158963_ChIP-Seq_LIVER_Mouse1.56008419
68* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.55145905
69EWS_26573619_Chip-Seq_HEK293_Human1.51633370
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51229357
71P300_19829295_ChIP-Seq_ESCs_Human1.50730274
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.50342696
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.49909100
74* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48860783
75ELK1_19687146_ChIP-ChIP_HELA_Human1.48691718
76* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47991365
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46895662
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46812787
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46464979
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.46423216
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44651810
82TAF15_26573619_Chip-Seq_HEK293_Human1.44264729
83TBX3_20139965_ChIP-Seq_ESCs_Mouse1.43944275
84E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43719323
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.42991976
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42846939
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42793288
88TBX3_20139965_ChIP-Seq_MESCs_Mouse1.42768207
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42196219
90TP53_18474530_ChIP-ChIP_U2OS_Human1.41755142
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.41666804
92TP53_16413492_ChIP-PET_HCT116_Human1.41335729
93* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40380349
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38267946
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36914919
96* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36121392
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34796578
98MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34466622
99EZH2_27304074_Chip-Seq_ESCs_Mouse1.34042243
100* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33180070
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32540327
102HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31965660
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30869656
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.30667585
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29913231
106PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29679280
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29476296
108SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29476296
109SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28699949
110* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.28396184
111* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28172013
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27538338
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26924750
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26753628
115* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.25211607
116EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24547803
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23776732
118* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.23349528
119* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.22896250
120* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22731274
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22465690
122* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22406981
123EGR1_19374776_ChIP-ChIP_THP-1_Human1.22132713
124NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20671956
125MYC_18940864_ChIP-ChIP_HL60_Human1.20216696
126* UBF1/2_26484160_Chip-Seq_HMECs_Human1.19229467
127* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18724633
128* AR_21572438_ChIP-Seq_LNCaP_Human1.17558743
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17484121
130AHR_22903824_ChIP-Seq_MCF-7_Human1.16661402
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15281865
132* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14849426
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14480750
134BCAT_22108803_ChIP-Seq_LS180_Human1.14408813
135* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14199693
136* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13978996
137JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13553199
138KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12268385
139AR_21909140_ChIP-Seq_LNCAP_Human1.11916120
140* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11900694
141RING1B_27294783_Chip-Seq_NPCs_Mouse1.11585370
142ARNT_22903824_ChIP-Seq_MCF-7_Human1.11339622
143NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09742829
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09142850
145PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08757158
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07750006
147NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07576640
148TP63_19390658_ChIP-ChIP_HaCaT_Human1.07336634
149POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07034423
150RNF2_27304074_Chip-Seq_ESCs_Mouse1.05800372
151* SOX2_20726797_ChIP-Seq_SW620_Human1.05598589
152ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05510690
153SOX17_20123909_ChIP-Seq_XEN_Mouse1.05486739
154TCF4_18268006_ChIP-ChIP_LS174T_Human1.04527959
155* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04384780
156GATA1_26923725_Chip-Seq_HPCs_Mouse1.04171167
157* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03361049
158CDX2_20551321_ChIP-Seq_CACO-2_Human1.02117842
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00315906
160* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99161663
161PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99099476
162FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98722607
163NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97353678
164* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97095995
165JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95650111
166PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95560525
167MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95233031
168PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94042086
169ETS1_20019798_ChIP-Seq_JURKAT_Human0.92982527
170* NANOG_16518401_ChIP-PET_MESCs_Mouse0.92560004
171TTF2_22483619_ChIP-Seq_HELA_Human0.91640075
172THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89929873
173SOX9_26525672_Chip-Seq_HEART_Mouse0.89770315
174STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89515591
175* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89164047
176ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88195752
177ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87998996
178RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87772931
179E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87652217
180* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87366997
181ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86940803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.83280167
2MP0008438_abnormal_cutaneous_collagen4.33105852
3MP0003705_abnormal_hypodermis_morpholog3.34598157
4MP0005275_abnormal_skin_tensile3.17125863
5MP0005503_abnormal_tendon_morphology3.12185590
6MP0004185_abnormal_adipocyte_glucose3.02605420
7MP0006292_abnormal_olfactory_placode2.98371297
8MP0010030_abnormal_orbit_morphology2.97426595
9MP0004272_abnormal_basement_membrane2.90903392
10MP0010368_abnormal_lymphatic_system2.74539090
11MP0003279_aneurysm2.57138980
12MP0009053_abnormal_anal_canal2.38443945
13MP0009384_cardiac_valve_regurgitation2.28377121
14MP0003890_abnormal_embryonic-extraembry2.26805230
15MP0005623_abnormal_meninges_morphology2.11354894
16MP0003693_abnormal_embryo_hatching2.08674651
17MP0003385_abnormal_body_wall1.95537782
18MP0004957_abnormal_blastocyst_morpholog1.93050509
19MP0000537_abnormal_urethra_morphology1.91245793
20MP0002837_dystrophic_cardiac_calcinosis1.84734109
21MP0003122_maternal_imprinting1.82046605
22MP0003942_abnormal_urinary_system1.76822924
23* MP0009250_abnormal_appendicular_skeleto1.73305032
24MP0004084_abnormal_cardiac_muscle1.71535552
25MP0001958_emphysema1.71233243
26MP0002234_abnormal_pharynx_morphology1.69473294
27MP0000534_abnormal_ureter_morphology1.68595764
28MP0005508_abnormal_skeleton_morphology1.65895876
29MP0006054_spinal_hemorrhage1.64531615
30MP0008932_abnormal_embryonic_tissue1.64431102
31MP0003566_abnormal_cell_adhesion1.61592413
32MP0002233_abnormal_nose_morphology1.59216484
33MP0000733_abnormal_muscle_development1.57006810
34MP0000767_abnormal_smooth_muscle1.55624036
35MP0002108_abnormal_muscle_morphology1.55556799
36MP0008057_abnormal_DNA_replication1.53685532
37MP0000049_abnormal_middle_ear1.52782869
38MP0003123_paternal_imprinting1.51509629
39MP0000428_abnormal_craniofacial_morphol1.51097862
40MP0002249_abnormal_larynx_morphology1.50343016
41MP0003111_abnormal_nucleus_morphology1.50158250
42MP0003935_abnormal_craniofacial_develop1.50040447
43MP0009672_abnormal_birth_weight1.50032062
44MP0004133_heterotaxia1.49997174
45MP0003941_abnormal_skin_development1.46490237
46MP0001299_abnormal_eye_distance/1.46072141
47MP0000516_abnormal_urinary_system1.45205533
48MP0005367_renal/urinary_system_phenotyp1.45205533
49MP0006138_congestive_heart_failure1.44283036
50MP0002282_abnormal_trachea_morphology1.43016306
51MP0003755_abnormal_palate_morphology1.41361458
52MP0000762_abnormal_tongue_morphology1.40699500
53MP0001879_abnormal_lymphatic_vessel1.40291792
54MP0001853_heart_inflammation1.39670509
55MP0008789_abnormal_olfactory_epithelium1.36855733
56MP0003115_abnormal_respiratory_system1.36813254
57MP0000750_abnormal_muscle_regeneration1.35828409
58MP0003938_abnormal_ear_development1.35629651
59MP0002932_abnormal_joint_morphology1.34848157
60MP0001286_abnormal_eye_development1.34827366
61MP0008877_abnormal_DNA_methylation1.34449818
62MP0002084_abnormal_developmental_patter1.34099662
63MP0000751_myopathy1.32650494
64MP0008058_abnormal_DNA_repair1.31188195
65MP0010094_abnormal_chromosome_stability1.30403280
66MP0002896_abnormal_bone_mineralization1.30034944
67MP0002060_abnormal_skin_morphology1.29798423
68MP0003937_abnormal_limbs/digits/tail_de1.27137199
69MP0001485_abnormal_pinna_reflex1.26280224
70MP0002085_abnormal_embryonic_tissue1.25094689
71MP0002295_abnormal_pulmonary_circulatio1.23217680
72MP0003283_abnormal_digestive_organ1.23181827
73* MP0000163_abnormal_cartilage_morphology1.22474315
74MP0003567_abnormal_fetal_cardiomyocyte1.19598085
75MP0010630_abnormal_cardiac_muscle1.17870818
76MP0005330_cardiomyopathy1.17557665
77MP0003252_abnormal_bile_duct1.16154795
78MP0004215_abnormal_myocardial_fiber1.15713843
79MP0002938_white_spotting1.15583096
80MP0004087_abnormal_muscle_fiber1.15054076
81MP0003828_pulmonary_edema1.14839544
82MP0003119_abnormal_digestive_system1.12230629
83MP0004233_abnormal_muscle_weight1.11897097
84MP0000432_abnormal_head_morphology1.10677039
85MP0005023_abnormal_wound_healing1.08250895
86MP0002972_abnormal_cardiac_muscle1.07475379
87MP0002697_abnormal_eye_size1.05195890
88MP0003718_maternal_effect1.04987076
89MP0000749_muscle_degeneration1.04685509
90MP0002102_abnormal_ear_morphology1.04586602
91MP0005076_abnormal_cell_differentiation1.01809842
92MP0005187_abnormal_penis_morphology1.01785629
93MP0003077_abnormal_cell_cycle1.00546305
94MP0001730_embryonic_growth_arrest0.99135498
95MP0000631_abnormal_neuroendocrine_gland0.99120418
96MP0002116_abnormal_craniofacial_bone0.99098775
97MP0001177_atelectasis0.98548138
98MP0004036_abnormal_muscle_relaxation0.97731228
99MP0001666_abnormal_nutrient_absorption0.97529525
100MP0005380_embryogenesis_phenotype0.96275951
101MP0001672_abnormal_embryogenesis/_devel0.96275951
102MP0003137_abnormal_impulse_conducting0.95793994
103MP0001661_extended_life_span0.95538026
104MP0005257_abnormal_intraocular_pressure0.95258253
105MP0002128_abnormal_blood_circulation0.94484242
106MP0009703_decreased_birth_body0.93336461
107MP0004145_abnormal_muscle_electrophysio0.93245561
108MP0008007_abnormal_cellular_replicative0.93101598
109MP0001270_distended_abdomen0.92993934
110MP0006072_abnormal_retinal_apoptosis0.92623419
111MP0002925_abnormal_cardiovascular_devel0.92383058
112MP0002168_other_aberrant_phenotype0.90969653
113MP0002009_preneoplasia0.90779629
114MP0004197_abnormal_fetal_growth/weight/0.90388961
115MP0005620_abnormal_muscle_contractility0.90008774
116MP0001544_abnormal_cardiovascular_syste0.89433425
117MP0005385_cardiovascular_system_phenoty0.89433425
118MP0002254_reproductive_system_inflammat0.89332056
119MP0003136_yellow_coat_color0.89146103
120MP0002092_abnormal_eye_morphology0.88617736
121MP0001697_abnormal_embryo_size0.88390904
122MP0003091_abnormal_cell_migration0.87108745
123* MP0002115_abnormal_skeleton_extremities0.86439375
124MP0003984_embryonic_growth_retardation0.86357410
125MP0005248_abnormal_Harderian_gland0.86191436
126MP0000579_abnormal_nail_morphology0.85635105
127MP0002088_abnormal_embryonic_growth/wei0.85237932
128MP0002653_abnormal_ependyma_morphology0.84763515
129MP0001340_abnormal_eyelid_morphology0.84351059
130MP0003121_genomic_imprinting0.83738854
131* MP0000266_abnormal_heart_morphology0.83705167
132MP0005499_abnormal_olfactory_system0.83473873
133MP0005394_taste/olfaction_phenotype0.83473873
134MP0008775_abnormal_heart_ventricle0.83379031
135MP0004147_increased_porphyrin_level0.82567407
136MP0005369_muscle_phenotype0.81771119
137MP0002111_abnormal_tail_morphology0.81258021
138MP0010352_gastrointestinal_tract_polyps0.80913296
139MP0002109_abnormal_limb_morphology0.80130642
140MP0005666_abnormal_adipose_tissue0.78862679
141MP0001293_anophthalmia0.78638949
142MP0001614_abnormal_blood_vessel0.78269235
143MP0001188_hyperpigmentation0.77823970
144MP0003861_abnormal_nervous_system0.73220852
145MP0000566_synostosis0.70979118
146MP0000350_abnormal_cell_proliferation0.63598974
147MP0002080_prenatal_lethality0.62548101
148MP0002086_abnormal_extraembryonic_tissu0.61976560
149MP0004130_abnormal_muscle_cell0.61725406
150MP0002177_abnormal_outer_ear0.61038914

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)4.96952229
2Protrusio acetabuli (HP:0003179)4.60562302
3Premature rupture of membranes (HP:0001788)4.50771192
4Broad metatarsal (HP:0001783)3.92268749
5Abnormality of the middle phalanges of the toes (HP:0010183)3.91791509
6Shallow orbits (HP:0000586)3.86853650
7Ankle contracture (HP:0006466)3.73821946
8Right ventricular cardiomyopathy (HP:0011663)3.68368911
9Abnormality of the proximal phalanges of the hand (HP:0009834)3.41515250
10Abnormality of the labia minora (HP:0012880)3.37489853
11Maternal diabetes (HP:0009800)3.27412238
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.19389847
13Short 4th metacarpal (HP:0010044)3.19389847
14Aortic dissection (HP:0002647)3.16486636
15Humeroradial synostosis (HP:0003041)3.13130847
16Synostosis involving the elbow (HP:0003938)3.13130847
17Aortic aneurysm (HP:0004942)3.09386914
18Fused cervical vertebrae (HP:0002949)3.03343310
19Colon cancer (HP:0003003)3.01882300
20Increased connective tissue (HP:0009025)2.97949618
21Aplasia/Hypoplasia of the sternum (HP:0006714)2.93046700
22Cerebral aneurysm (HP:0004944)2.87531595
23Abnormality of the calf musculature (HP:0001430)2.86091551
24Morphological abnormality of the middle ear (HP:0008609)2.85684779
25Bladder diverticulum (HP:0000015)2.84400103
26Absent septum pellucidum (HP:0001331)2.84022038
27Abnormality of the 4th metacarpal (HP:0010012)2.81513204
28Atrophic scars (HP:0001075)2.81500676
29Mildly elevated creatine phosphokinase (HP:0008180)2.80915310
30Muscle fiber splitting (HP:0003555)2.78274704
31Type 1 muscle fiber predominance (HP:0003803)2.73489380
32Abnormality of the septum pellucidum (HP:0007375)2.66813917
33Spinal rigidity (HP:0003306)2.65070969
34Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.64022353
35Short 1st metacarpal (HP:0010034)2.64022353
36Dilatation of the ascending aorta (HP:0005111)2.58201048
37Pulmonary artery stenosis (HP:0004415)2.57393724
38Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.56354578
39Scapular winging (HP:0003691)2.56153232
40Hepatoblastoma (HP:0002884)2.54597769
412-3 toe syndactyly (HP:0004691)2.53696840
42Mitral valve prolapse (HP:0001634)2.53351146
43Cutaneous finger syndactyly (HP:0010554)2.52317258
44Sudden death (HP:0001699)2.49708326
45Patent foramen ovale (HP:0001655)2.48937563
46Soft skin (HP:0000977)2.47992366
47Abnormality of the phalanges of the 5th finger (HP:0004213)2.47481407
48Synostosis of carpal bones (HP:0005048)2.46310385
49Hypoglycemic seizures (HP:0002173)2.45468816
50Wormian bones (HP:0002645)2.45016438
51Abnormality of homocysteine metabolism (HP:0010919)2.42840748
52Homocystinuria (HP:0002156)2.42840748
53Cutaneous syndactyly (HP:0012725)2.42688269
54Aplasia/hypoplasia of the humerus (HP:0006507)2.40095723
55Abnormal lung lobation (HP:0002101)2.39909686
56Fragile skin (HP:0001030)2.39907464
57Short hallux (HP:0010109)2.37701149
58Optic nerve hypoplasia (HP:0000609)2.36119113
59Lymphangioma (HP:0100764)2.35505492
60Short humerus (HP:0005792)2.35156376
61Broad thumb (HP:0011304)2.34579479
62Bilateral microphthalmos (HP:0007633)2.33177551
63Aneurysm (HP:0002617)2.32110998
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.31183298
65Blue sclerae (HP:0000592)2.27901147
66Vascular tortuosity (HP:0004948)2.27866864
67Rectal prolapse (HP:0002035)2.26823618
68Osteolytic defects of the hand bones (HP:0009699)2.26154757
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.26154757
70Renal duplication (HP:0000075)2.25683910
71Wide anterior fontanel (HP:0000260)2.25600240
72Abnormality of the 1st metacarpal (HP:0010009)2.25552003
73Spastic diplegia (HP:0001264)2.25073750
74Supernumerary spleens (HP:0009799)2.18692713
75Abnormality of the nasal septum (HP:0000419)2.17141218
76Aplasia/Hypoplasia of the hallux (HP:0008362)2.15541571
77Choanal stenosis (HP:0000452)2.14006869
78Methylmalonic acidemia (HP:0002912)2.11881206
79Camptodactyly of toe (HP:0001836)2.11162882
80Lipoatrophy (HP:0100578)2.10975364
81Cervical subluxation (HP:0003308)2.09890318
82Long nose (HP:0003189)2.08472164
83Neonatal short-limb short stature (HP:0008921)2.07880574
84Coronal craniosynostosis (HP:0004440)2.07398851
85Hyperinsulinemic hypoglycemia (HP:0000825)2.05873445
86Absent phalangeal crease (HP:0006109)2.04414912
87Stenosis of the external auditory canal (HP:0000402)2.04179373
88Preaxial foot polydactyly (HP:0001841)2.03350573
89Fibular aplasia (HP:0002990)2.02698104
90Facial cleft (HP:0002006)2.02102571
91Short nail (HP:0001799)2.01654370
92Microglossia (HP:0000171)2.01509411
93Follicular hyperkeratosis (HP:0007502)2.01287964
94Thin bony cortex (HP:0002753)2.00429888
95Deviation of the hallux (HP:0010051)1.99803750
96Ventricular tachycardia (HP:0004756)1.99302762
97Abnormality of the metopic suture (HP:0005556)1.98838420
98Anophthalmia (HP:0000528)1.98836893
99Bifid tongue (HP:0010297)1.98570670
100Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.95764527
101Abnormality of the distal phalanges of the toes (HP:0010182)1.95715078
102Overgrowth (HP:0001548)1.95618469
103Subaortic stenosis (HP:0001682)1.95322801
104Abnormality of the left ventricular outflow tract (HP:0011103)1.95322801
105Midline defect of the nose (HP:0004122)1.95110660
106Nephroblastoma (Wilms tumor) (HP:0002667)1.95048999
107Abnormality of dentin (HP:0010299)1.94341620
108Embryonal renal neoplasm (HP:0011794)1.94229578
109Pancreatic islet-cell hyperplasia (HP:0004510)1.93037687
110Broad phalanx (HP:0006009)1.92808262
111Broad toe (HP:0001837)1.91550662
112Prominent metopic ridge (HP:0005487)1.91496748
113Hyperglycinemia (HP:0002154)1.90325387
114Mesomelia (HP:0003027)1.90038257
115Broad phalanges of the hand (HP:0009768)1.89702599
116Broad finger (HP:0001500)1.89673948
117Broad hallux (HP:0010055)1.89095108
118Ependymoma (HP:0002888)1.87935039
119Hyporeflexia of lower limbs (HP:0002600)1.87695293
120Knee flexion contracture (HP:0006380)1.87687869
121Hallux valgus (HP:0001822)1.87625152
122Myelomeningocele (HP:0002475)1.86657743
123Atrial fibrillation (HP:0005110)1.85646261
124Abnormal number of incisors (HP:0011064)1.82678730
125Bronchomalacia (HP:0002780)1.82229038
126Ectopic kidney (HP:0000086)1.82014192
127Down-sloping shoulders (HP:0200021)1.81905941
128Buphthalmos (HP:0000557)1.81835243
129Turricephaly (HP:0000262)1.81389879
130Difficulty climbing stairs (HP:0003551)1.81341969
131Meckel diverticulum (HP:0002245)1.80653424
132Asymmetry of the thorax (HP:0001555)1.79904277
133Carpal synostosis (HP:0009702)1.79881987
134Periauricular skin pits (HP:0100277)1.79868189
135Preauricular pit (HP:0004467)1.79868189
136Short phalanx of the thumb (HP:0009660)1.79446157
137Hyperextensible skin (HP:0000974)1.79126722
138Hip contracture (HP:0003273)1.78471122
139Abdominal situs inversus (HP:0003363)1.77897335
140Abnormality of abdominal situs (HP:0011620)1.77897335
141Abnormality of methionine metabolism (HP:0010901)1.76692597
142Distal lower limb amyotrophy (HP:0008944)1.75805398
143True hermaphroditism (HP:0010459)1.75178789
144Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75109542
145Neoplasm of the adrenal cortex (HP:0100641)1.74952046
146Long toe (HP:0010511)1.74652801
147Broad ribs (HP:0000885)1.73753560
148Elbow flexion contracture (HP:0002987)1.73552510
149Joint laxity (HP:0001388)1.72842485
150Selective tooth agenesis (HP:0001592)1.72839908
151Arterial tortuosity (HP:0005116)1.72754084
152Mitral regurgitation (HP:0001653)1.72382875
153Bowel diverticulosis (HP:0005222)1.72315145
154Peritonitis (HP:0002586)1.72149446
155Hypoplastic pelvis (HP:0008839)1.71505020
156Absent toe (HP:0010760)1.71448436
157Methylmalonic aciduria (HP:0012120)1.71279199
158Hypoplastic ischia (HP:0003175)1.71268853
159Aqueductal stenosis (HP:0002410)1.70788561
160Ectopia lentis (HP:0001083)1.70065984
161Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.69872749
162Hypoplastic labia majora (HP:0000059)1.69733294
163Broad long bones (HP:0005622)1.67896417
164Aplasia/Hypoplasia of the fibula (HP:0006492)1.67838497
165Spondylolisthesis (HP:0003302)1.67520352
166Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66524710
167Primary atrial arrhythmia (HP:0001692)1.66027200
168Exostoses (HP:0100777)1.66020230
169Chromsome breakage (HP:0040012)1.65783838
170Abnormal finger flexion creases (HP:0006143)1.63726132
171Abnormality of the ileum (HP:0001549)1.63643882
172Increased variability in muscle fiber diameter (HP:0003557)1.63414356
173Abnormality of the ischium (HP:0003174)1.63229374
174Spinal cord lesions (HP:0100561)1.63063058
175Syringomyelia (HP:0003396)1.63063058
176Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62935794
177Skin pits (HP:0100276)1.62831993
178Supraventricular arrhythmia (HP:0005115)1.62611901
179Tarsal synostosis (HP:0008368)1.62249091
180Wrist flexion contracture (HP:0001239)1.62095761
181Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62072710
182Natal tooth (HP:0000695)1.60760221
183Symptomatic seizures (HP:0011145)1.60490034
184Abnormality of the labia majora (HP:0012881)1.60278686
185Genu recurvatum (HP:0002816)1.59799630
186Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.59705870
187Carpal bone hypoplasia (HP:0001498)1.57207926
188Birth length less than 3rd percentile (HP:0003561)1.57051538
189Absent radius (HP:0003974)1.56431645
190Esophageal atresia (HP:0002032)1.56180506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA34.01911564
2LATS14.01522288
3EPHB23.79510611
4CDC73.25419084
5MAP3K93.13646229
6PDGFRA3.05972899
7TTN3.05685870
8BUB13.03031552
9VRK22.80778507
10DDR22.78296485
11TTK2.70495493
12TNIK2.69330031
13TAF12.51537227
14PLK32.38702870
15TRIB32.36448693
16STK162.27661886
17SIK12.22869724
18FRK2.13704699
19DMPK2.13246567
20SRPK12.12040199
21LATS22.08094726
22MYLK1.98114581
23PBK1.96026550
24TSSK61.94146927
25STK38L1.91057746
26RIPK11.89244653
27FGFR41.86081289
28MAP3K31.85629210
29LMTK21.80698302
30PKN21.76978414
31MST41.76913914
32PLK41.66730664
33BRSK21.64552082
34NLK1.63198035
35NUAK11.57840712
36VRK11.55259392
37PAK31.50406782
38FER1.48722113
39WNK31.47255820
40PTK61.47184667
41ERN11.42332619
42TRIM281.36584564
43ZAK1.35991706
44PTK21.34000110
45DYRK21.33180951
46PAK21.32017289
47PLK11.30044334
48MET1.28682703
49ERBB31.28115935
50NEK11.26178213
51FGFR21.23148108
52STK31.22469309
53MTOR1.18665603
54ACVR1B1.16784162
55PDGFRB1.15853482
56NME11.15283112
57ROCK11.15159726
58CSNK1G11.14807347
59MAP3K21.13787723
60FGFR11.11148238
61CDK191.10199087
62EPHA21.07640679
63ILK1.07307231
64INSRR1.07271469
65MAP3K101.05844514
66GRK11.04888455
67STK41.02526393
68PAK41.02116855
69ERBB41.01900418
70WEE11.00964497
71STK240.99003343
72YES10.97912103
73DYRK30.97109994
74TGFBR10.94082364
75BMPR1B0.93093397
76BMX0.92536571
77CAMK1G0.92418204
78CHEK20.91672276
79TRPM70.91428142
80WNK40.89837117
81CDC42BPA0.87392306
82EPHB10.86702954
83OBSCN0.84649998
84BRSK10.82902534
85NEK20.82032008
86NEK90.80898892
87MKNK20.80141212
88ERBB20.79903922
89ATR0.79816269
90WNK10.79045120
91MELK0.78527842
92RPS6KB20.77951229
93CASK0.75318931
94TGFBR20.73833453
95AURKB0.72766809
96ALK0.72222911
97MAP3K70.72153023
98MAPK150.72087979
99MKNK10.71926918
100MAPKAPK30.71615461
101PIK3CA0.70806006
102TIE10.69590207
103CDK60.68292638
104ATM0.67792902
105OXSR10.67362942
106CHEK10.66807163
107MAP2K10.65011569
108FGFR30.63310149
109FLT30.61647909
110SMG10.61245993
111PDK20.59940562
112PRKD10.59879542
113GSK3A0.59324637
114PLK20.58494965
115CDK120.57982234
116MUSK0.57847206
117PNCK0.57390129
118RPS6KA40.57041351
119EIF2AK20.55472962
120STK380.55166419
121CSNK1G20.52640505
122PRKD30.51461346
123HIPK20.51293109
124LRRK20.50582844
125ROCK20.50349146
126CSNK1G30.48456662
127EIF2AK30.47471948
128RIPK40.46668993
129PRKDC0.44980732
130CSNK1E0.44103823
131CDK30.43618594
132RET0.43398512
133DYRK1B0.43300245
134PRKCE0.43208378
135CHUK0.42090563
136PTK2B0.39931191
137CDK20.38750892
138PRKAA20.37181586
139EEF2K0.37116511
140PRKCH0.36677675
141BCR0.36309194
142KSR10.35987953
143INSR0.35491624
144PDK30.35435359
145PDK40.35435359
146BRD40.35025941
147AURKA0.34767711
148MST1R0.34304561
149CDK10.34231189
150AKT20.33425437
151CSNK2A10.32803229
152CAMK40.32343498
153TAOK20.31665656
154PRKCG0.31171170
155CSNK2A20.30928165
156CAMK1D0.30869644
157MAPK10.30854393
158ADRBK10.30717361
159CSNK1A10.30486336
160MAP3K40.30350722
161CDK70.30052013
162IGF1R0.30026084
163CSNK1A1L0.29684757
164MOS0.27776513
165NTRK10.27750119
166PIK3CG0.27544105
167PASK0.27477307

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.17832369
2DNA replication_Homo sapiens_hsa030302.98013511
3Mismatch repair_Homo sapiens_hsa034302.81342813
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.59911134
5Non-homologous end-joining_Homo sapiens_hsa034502.54995305
6Dilated cardiomyopathy_Homo sapiens_hsa054142.54823518
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54282558
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.49346039
9Focal adhesion_Homo sapiens_hsa045102.45799559
10Basal cell carcinoma_Homo sapiens_hsa052172.38982040
11Proteasome_Homo sapiens_hsa030502.30482540
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.25983673
13One carbon pool by folate_Homo sapiens_hsa006702.21073933
14Homologous recombination_Homo sapiens_hsa034402.14997739
15Adherens junction_Homo sapiens_hsa045202.14146221
16Protein digestion and absorption_Homo sapiens_hsa049742.12696154
17Hippo signaling pathway_Homo sapiens_hsa043902.08967837
18TGF-beta signaling pathway_Homo sapiens_hsa043502.07999860
19Spliceosome_Homo sapiens_hsa030401.99882195
20RNA polymerase_Homo sapiens_hsa030201.99422937
21Hedgehog signaling pathway_Homo sapiens_hsa043401.99020751
22Proteoglycans in cancer_Homo sapiens_hsa052051.90981363
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84914328
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.83477510
25RNA transport_Homo sapiens_hsa030131.79522456
26Fatty acid degradation_Homo sapiens_hsa000711.72962958
27Cell cycle_Homo sapiens_hsa041101.72293266
28Protein export_Homo sapiens_hsa030601.67537891
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64217675
30Nucleotide excision repair_Homo sapiens_hsa034201.62146381
31Amoebiasis_Homo sapiens_hsa051461.61932654
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.60644845
33Ribosome_Homo sapiens_hsa030101.57729160
34RNA degradation_Homo sapiens_hsa030181.56113864
35Basal transcription factors_Homo sapiens_hsa030221.54513097
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.53186461
37Lysine degradation_Homo sapiens_hsa003101.47575090
38Steroid biosynthesis_Homo sapiens_hsa001001.47229488
39Small cell lung cancer_Homo sapiens_hsa052221.46357981
40Starch and sucrose metabolism_Homo sapiens_hsa005001.41013890
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40558072
42MicroRNAs in cancer_Homo sapiens_hsa052061.39538513
43Vitamin B6 metabolism_Homo sapiens_hsa007501.38687284
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38645535
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36994359
46Chemical carcinogenesis_Homo sapiens_hsa052041.36402953
47Tryptophan metabolism_Homo sapiens_hsa003801.36257215
48Tight junction_Homo sapiens_hsa045301.36047600
49Vitamin digestion and absorption_Homo sapiens_hsa049771.32918948
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31333999
51Pyruvate metabolism_Homo sapiens_hsa006201.30207402
52Fanconi anemia pathway_Homo sapiens_hsa034601.29721944
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25482941
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25075307
55Base excision repair_Homo sapiens_hsa034101.22926458
56Primary bile acid biosynthesis_Homo sapiens_hsa001201.20132243
57Viral myocarditis_Homo sapiens_hsa054161.18650156
58Wnt signaling pathway_Homo sapiens_hsa043101.12249697
59Propanoate metabolism_Homo sapiens_hsa006401.11944443
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11479310
61Bladder cancer_Homo sapiens_hsa052191.10677931
62PI3K-Akt signaling pathway_Homo sapiens_hsa041511.09333326
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.07977281
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07340112
65Insulin resistance_Homo sapiens_hsa049311.06644651
66Melanoma_Homo sapiens_hsa052181.06220680
67mRNA surveillance pathway_Homo sapiens_hsa030151.05200485
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04558079
69Biosynthesis of amino acids_Homo sapiens_hsa012301.03912432
70Prostate cancer_Homo sapiens_hsa052151.03567921
71Sulfur metabolism_Homo sapiens_hsa009201.02767971
72Axon guidance_Homo sapiens_hsa043601.01814537
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01659549
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.97807498
75p53 signaling pathway_Homo sapiens_hsa041150.96795980
76Complement and coagulation cascades_Homo sapiens_hsa046100.95872208
77Melanogenesis_Homo sapiens_hsa049160.94384448
78Pathways in cancer_Homo sapiens_hsa052000.94098744
79Oxidative phosphorylation_Homo sapiens_hsa001900.92850508
80Fatty acid metabolism_Homo sapiens_hsa012120.92458900
81Butanoate metabolism_Homo sapiens_hsa006500.92448324
82Purine metabolism_Homo sapiens_hsa002300.88779611
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88510847
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88391105
85Nitrogen metabolism_Homo sapiens_hsa009100.88314261
86Fatty acid elongation_Homo sapiens_hsa000620.87835420
87Cardiac muscle contraction_Homo sapiens_hsa042600.86058318
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85823302
89Folate biosynthesis_Homo sapiens_hsa007900.84524115
90Parkinsons disease_Homo sapiens_hsa050120.83637217
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82554016
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82253999
93Huntingtons disease_Homo sapiens_hsa050160.81902064
94Pyrimidine metabolism_Homo sapiens_hsa002400.81451692
95Notch signaling pathway_Homo sapiens_hsa043300.80597356
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.79286607
97Galactose metabolism_Homo sapiens_hsa000520.77857288
98N-Glycan biosynthesis_Homo sapiens_hsa005100.77795786
99PPAR signaling pathway_Homo sapiens_hsa033200.77351818
100Bile secretion_Homo sapiens_hsa049760.76045854
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75647182
102Rap1 signaling pathway_Homo sapiens_hsa040150.75507304
103Chronic myeloid leukemia_Homo sapiens_hsa052200.74021362
104Caffeine metabolism_Homo sapiens_hsa002320.73275084
105Glutathione metabolism_Homo sapiens_hsa004800.71503793
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.70927011
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70795808
108Glucagon signaling pathway_Homo sapiens_hsa049220.69530104
109Retinol metabolism_Homo sapiens_hsa008300.69444257
110Oocyte meiosis_Homo sapiens_hsa041140.68822837
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67879234
112Phenylalanine metabolism_Homo sapiens_hsa003600.66700754
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64605434
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64128076
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.63426409
116Endometrial cancer_Homo sapiens_hsa052130.62953189
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61575040
118Dorso-ventral axis formation_Homo sapiens_hsa043200.61551785
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61338052
120Ovarian steroidogenesis_Homo sapiens_hsa049130.61127104
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59755063
122Prion diseases_Homo sapiens_hsa050200.59729034
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58447872
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58425216
125Arginine biosynthesis_Homo sapiens_hsa002200.56346950
126Thyroid cancer_Homo sapiens_hsa052160.54881889
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.54307238
128Alzheimers disease_Homo sapiens_hsa050100.53811874
129HTLV-I infection_Homo sapiens_hsa051660.53516422
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53511014
131Thyroid hormone synthesis_Homo sapiens_hsa049180.53243628
132Selenocompound metabolism_Homo sapiens_hsa004500.52646952
133Glioma_Homo sapiens_hsa052140.52412684
134Metabolic pathways_Homo sapiens_hsa011000.49184619
135Arginine and proline metabolism_Homo sapiens_hsa003300.48985422
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48318875
137Type II diabetes mellitus_Homo sapiens_hsa049300.47773728
138Estrogen signaling pathway_Homo sapiens_hsa049150.46642269
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46373644
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44654894
141AMPK signaling pathway_Homo sapiens_hsa041520.43961568
142Insulin signaling pathway_Homo sapiens_hsa049100.43159665
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42808223
144Carbon metabolism_Homo sapiens_hsa012000.42735342
145Gap junction_Homo sapiens_hsa045400.42528923
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.41328810
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41264517
148Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41249971
149Drug metabolism - other enzymes_Homo sapiens_hsa009830.40894911
150Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40461889
151Pancreatic cancer_Homo sapiens_hsa052120.40204609
152Systemic lupus erythematosus_Homo sapiens_hsa053220.32991826
153Fat digestion and absorption_Homo sapiens_hsa049750.32301388
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30568018

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