ROR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.56566244
2bone trabecula formation (GO:0060346)4.51038953
3polarized epithelial cell differentiation (GO:0030859)4.50737581
4heterochromatin organization (GO:0070828)4.35203332
5regulation of gene silencing by RNA (GO:0060966)4.28408154
6regulation of posttranscriptional gene silencing (GO:0060147)4.28408154
7regulation of gene silencing by miRNA (GO:0060964)4.28408154
8notochord development (GO:0030903)4.28097529
9sequestering of extracellular ligand from receptor (GO:0035581)4.17054796
10planar cell polarity pathway involved in neural tube closure (GO:0090179)4.13418343
11regulation of mesoderm development (GO:2000380)4.08425673
12regulation of cardioblast differentiation (GO:0051890)4.06494323
13establishment of apical/basal cell polarity (GO:0035089)4.00837255
14regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.92477903
15negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.89982518
16negative regulation of cell fate specification (GO:0009996)3.71957950
17atrioventricular valve morphogenesis (GO:0003181)3.69209427
18pre-miRNA processing (GO:0031054)3.66620383
19protein localization to kinetochore (GO:0034501)3.55394371
20anterior/posterior axis specification, embryo (GO:0008595)3.43974443
21establishment or maintenance of monopolar cell polarity (GO:0061339)3.39431318
22establishment of monopolar cell polarity (GO:0061162)3.39431318
23convergent extension (GO:0060026)3.31649939
24* regulation of establishment of planar polarity (GO:0090175)3.30595421
25outer ear morphogenesis (GO:0042473)3.29173804
26midgut development (GO:0007494)3.28284921
27DNA replication-dependent nucleosome assembly (GO:0006335)3.24522418
28DNA replication-dependent nucleosome organization (GO:0034723)3.24522418
29negative regulation of epidermis development (GO:0045683)3.22938065
30nuclear pore organization (GO:0006999)3.19317412
31regulation of telomere maintenance via telomerase (GO:0032210)3.19007732
32nuclear pore complex assembly (GO:0051292)3.18389426
33body morphogenesis (GO:0010171)3.16853162
34primitive streak formation (GO:0090009)3.16700696
35positive regulation of SMAD protein import into nucleus (GO:0060391)3.16194807
36cell migration involved in heart development (GO:0060973)3.15124246
37DNA unwinding involved in DNA replication (GO:0006268)3.13634881
38somite rostral/caudal axis specification (GO:0032525)3.13313586
39regulation of hippo signaling (GO:0035330)3.10837646
40ribosomal small subunit assembly (GO:0000028)3.08798963
41chromatin assembly (GO:0031497)3.08630925
42tooth mineralization (GO:0034505)3.08458082
43COPI coating of Golgi vesicle (GO:0048205)3.05539430
44Golgi transport vesicle coating (GO:0048200)3.05539430
45protein heterotrimerization (GO:0070208)3.01728767
46signal transduction involved in regulation of gene expression (GO:0023019)2.99792887
47regulation of apoptotic process involved in morphogenesis (GO:1902337)2.99067665
48regulation of gastrulation (GO:0010470)2.98665519
49atrial septum morphogenesis (GO:0060413)2.97399840
50branching involved in salivary gland morphogenesis (GO:0060445)2.97295303
51mitotic sister chromatid segregation (GO:0000070)2.97071192
52cellular response to BMP stimulus (GO:0071773)2.95831557
53response to BMP (GO:0071772)2.95831557
54maturation of SSU-rRNA (GO:0030490)2.95382379
55negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.94364601
56negative regulation of embryonic development (GO:0045992)2.93565708
57regulation of cell fate specification (GO:0042659)2.92898338
58mesenchyme development (GO:0060485)2.92654522
59proximal/distal pattern formation (GO:0009954)2.92375710
60regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.91120224
61gonadal mesoderm development (GO:0007506)2.91107645
62outflow tract septum morphogenesis (GO:0003148)2.89741121
63chondrocyte development (GO:0002063)2.89502228
64histone H4-K12 acetylation (GO:0043983)2.86663716
65trophectodermal cell differentiation (GO:0001829)2.86468181
66regulation of stem cell maintenance (GO:2000036)2.86417902
67regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.85666673
68regulation of SMAD protein import into nucleus (GO:0060390)2.84766933
69formation of translation preinitiation complex (GO:0001731)2.83474069
70regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.82092541
71axon extension involved in axon guidance (GO:0048846)2.81286163
72neuron projection extension involved in neuron projection guidance (GO:1902284)2.81286163
73G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.80748874
74anterior/posterior axis specification (GO:0009948)2.80673139
75positive regulation of catenin import into nucleus (GO:0035413)2.80098984
76dorsal/ventral axis specification (GO:0009950)2.80098296
77ribosomal small subunit biogenesis (GO:0042274)2.79682857
78cochlea morphogenesis (GO:0090103)2.79254470
79regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.78737382
80sister chromatid segregation (GO:0000819)2.78460798
81lateral sprouting from an epithelium (GO:0060601)2.77819109
82negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.75449918
83regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.74333579
84doxorubicin metabolic process (GO:0044598)2.73317560
85daunorubicin metabolic process (GO:0044597)2.73317560
86polyketide metabolic process (GO:0030638)2.73317560
87maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72336536
88head development (GO:0060322)2.72096136
89negative regulation of activin receptor signaling pathway (GO:0032926)2.72027752
90hippo signaling (GO:0035329)2.72019259
91cell migration involved in gastrulation (GO:0042074)2.71869863
92peptidyl-arginine omega-N-methylation (GO:0035247)2.68460880
93embryonic skeletal joint morphogenesis (GO:0060272)2.67315189
94histone arginine methylation (GO:0034969)2.67042207
95intestinal epithelial cell development (GO:0060576)2.66786189
96cell proliferation involved in metanephros development (GO:0072203)2.66580570
97viral transcription (GO:0019083)2.65406097
98establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.64997055
99DNA replication checkpoint (GO:0000076)2.64233659
100maternal placenta development (GO:0001893)2.63960116
101folic acid-containing compound biosynthetic process (GO:0009396)2.63663014
102regulation of mammary gland epithelial cell proliferation (GO:0033599)2.63537470
103cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.63513612
104negative regulation of cell fate commitment (GO:0010454)2.62853039
105positive regulation of smoothened signaling pathway (GO:0045880)2.62211368
106muscle organ morphogenesis (GO:0048644)2.62157416
107embryonic foregut morphogenesis (GO:0048617)2.61914046
108negative regulation of chondrocyte differentiation (GO:0032331)2.60987398
109regulation of nuclear cell cycle DNA replication (GO:0033262)2.60896062
110mRNA stabilization (GO:0048255)2.59056186
111RNA stabilization (GO:0043489)2.59056186
112negative regulation of striated muscle cell apoptotic process (GO:0010664)2.57769579
113translational termination (GO:0006415)2.57540356
114negative regulation of androgen receptor signaling pathway (GO:0060766)2.57356167
115anatomical structure regression (GO:0060033)2.57347458
116protein retention in ER lumen (GO:0006621)2.56037771
117collagen fibril organization (GO:0030199)2.55461151
118branching involved in mammary gland duct morphogenesis (GO:0060444)2.55323623
119* non-canonical Wnt signaling pathway (GO:0035567)2.55304314
120negative regulation of cartilage development (GO:0061037)2.54912159
121mesenchymal cell proliferation (GO:0010463)2.54697608
122positive regulation of gastrulation (GO:2000543)2.54583978
123protein localization to chromosome, centromeric region (GO:0071459)2.54500881
124hindlimb morphogenesis (GO:0035137)2.53462931
125regulation of non-canonical Wnt signaling pathway (GO:2000050)2.53340528
126pericardium development (GO:0060039)2.52466184
127basement membrane organization (GO:0071711)2.51400615
128regulation of translational fidelity (GO:0006450)2.51298866
129DNA duplex unwinding (GO:0032508)2.50191357
130bone morphogenesis (GO:0060349)2.49911562
131establishment of tissue polarity (GO:0007164)2.49798439
132establishment of planar polarity (GO:0001736)2.49798439
133mitotic chromosome condensation (GO:0007076)2.49265807
134cell surface receptor signaling pathway involved in heart development (GO:0061311)2.48251209
135collagen metabolic process (GO:0032963)2.47734216
136DNA geometric change (GO:0032392)2.47532453
137histone H4-K8 acetylation (GO:0043982)2.47307459
138histone H4-K5 acetylation (GO:0043981)2.47307459
139craniofacial suture morphogenesis (GO:0097094)2.47094068
140embryonic hindlimb morphogenesis (GO:0035116)2.45836595
141regulation of catenin import into nucleus (GO:0035412)2.44626922
142collagen catabolic process (GO:0030574)2.44567806
143* Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.44354233
144homocysteine metabolic process (GO:0050667)2.44097487
145positive regulation of cardiac muscle cell proliferation (GO:0060045)2.44088579
146chondrocyte proliferation (GO:0035988)2.43857318
147cell fate commitment involved in formation of primary germ layer (GO:0060795)2.43500297
148mammary gland development (GO:0030879)2.43475065
149pore complex assembly (GO:0046931)2.43473035
150embryonic body morphogenesis (GO:0010172)2.43179075
151digestive tract morphogenesis (GO:0048546)2.43106861
152negative regulation of telomerase activity (GO:0051974)2.42949155
153negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.41826942
154pituitary gland development (GO:0021983)2.41138881
155regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.40560536
156embryonic camera-type eye development (GO:0031076)2.40122531
157embryonic forelimb morphogenesis (GO:0035115)2.39679072
158middle ear morphogenesis (GO:0042474)2.39324780
159endodermal cell differentiation (GO:0035987)2.37783391
160negative regulation of DNA repair (GO:0045738)2.35568744
161nodal signaling pathway (GO:0038092)2.35550586
162regulation of heart morphogenesis (GO:2000826)2.34097280
163multicellular organismal macromolecule metabolic process (GO:0044259)2.32300790
164lung-associated mesenchyme development (GO:0060484)2.27875945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.80458132
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.33374670
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.33374670
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.33374670
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.28915764
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.11034578
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.06775631
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.96012144
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.70038731
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.66831731
11TCF3_18692474_ChIP-Seq_MEFs_Mouse2.65799238
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.54893449
13ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.53812344
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.47713843
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41932461
16TCF3_18692474_ChIP-Seq_MESCs_Mouse2.35860568
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.30120338
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28216334
19* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.28030978
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26502785
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.22637887
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.03582723
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02631201
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97325410
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93981567
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88124794
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85552036
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85503635
29NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.83884018
30* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.83462358
31* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80584753
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78925154
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78021827
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77165065
35SOX2_18555785_ChIP-Seq_MESCs_Mouse1.71747236
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70056878
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.69749269
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.67470852
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.67093801
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65180594
41* ISL1_27105846_Chip-Seq_CPCs_Mouse1.62899321
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.62164591
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60789347
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.59744607
45* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59230650
46KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.56969487
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53547160
48* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.53278695
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53230567
50NANOG_21062744_ChIP-ChIP_HESCs_Human1.52052165
51ZNF263_19887448_ChIP-Seq_K562_Human1.51151455
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50563935
53TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.50230707
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47261423
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46909771
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46784969
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43453539
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42956225
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42930123
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42930123
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42873988
62AR_21909140_ChIP-Seq_LNCAP_Human1.41314979
63NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.40132217
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39583736
65SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.39412056
66MYC_22102868_ChIP-Seq_BL_Human1.38772837
67XRN2_22483619_ChIP-Seq_HELA_Human1.38326197
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37796034
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.37627210
70SOX2_18692474_ChIP-Seq_MEFs_Mouse1.36216472
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.35377766
72* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34417428
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33765206
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31684768
75* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28738555
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28277593
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28208042
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27505061
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.26405052
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25216897
81SOX2_18692474_ChIP-Seq_MESCs_Mouse1.24732265
82* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22961248
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22642130
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.22334590
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.22242202
86* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.19926811
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18341058
88NANOG_18692474_ChIP-Seq_MEFs_Mouse1.17172749
89EOMES_21245162_ChIP-Seq_HESCs_Human1.17129081
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17020832
91* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16861758
92CLOCK_20551151_ChIP-Seq_293T_Human1.16861335
93* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15961844
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15816972
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15178221
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14314287
97TTF2_22483619_ChIP-Seq_HELA_Human1.12846158
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12218423
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11821570
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11074233
101POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11047006
102NANOG_18692474_ChIP-Seq_MESCs_Mouse1.10933718
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10439611
104WT1_19549856_ChIP-ChIP_CCG9911_Human1.10113222
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.09907853
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.08119132
107RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07369162
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06780216
109* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06717035
110* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06159382
111E2F1_21310950_ChIP-Seq_MCF-7_Human1.05940395
112ELK3_25401928_ChIP-Seq_HUVEC_Human1.05389051
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05104401
114EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03987100
115TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03790941
116RING1B_27294783_Chip-Seq_ESCs_Mouse1.02538612
117TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02208941
118* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02044309
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02009316
120* NANOG_16518401_ChIP-PET_MESCs_Mouse1.01636111
121SOX2_16153702_ChIP-ChIP_HESCs_Human1.01170882
122SOX17_20123909_ChIP-Seq_XEN_Mouse1.00926318
123CHD1_26751641_Chip-Seq_LNCaP_Human1.00766659
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00479742
125TP53_22127205_ChIP-Seq_IMR90_Human0.99659664
126KDM2B_26808549_Chip-Seq_K562_Human0.99063954
127FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98967654
128RACK7_27058665_Chip-Seq_MCF-7_Human0.96486963
129THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95937095
130JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95600563
131TFEB_21752829_ChIP-Seq_HELA_Human0.93496649
132ATF3_27146783_Chip-Seq_COLON_Human0.93150810

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting3.22887339
2MP0003122_maternal_imprinting3.18180312
3MP0003705_abnormal_hypodermis_morpholog3.10583316
4MP0008438_abnormal_cutaneous_collagen2.92860353
5* MP0010030_abnormal_orbit_morphology2.67686300
6MP0003283_abnormal_digestive_organ2.66457442
7MP0003121_genomic_imprinting2.30923251
8MP0005503_abnormal_tendon_morphology2.28942390
9MP0003890_abnormal_embryonic-extraembry2.21902027
10MP0000678_abnormal_parathyroid_gland2.16192148
11MP0003119_abnormal_digestive_system2.11147855
12MP0005275_abnormal_skin_tensile2.01832180
13MP0010352_gastrointestinal_tract_polyps2.00674615
14MP0009053_abnormal_anal_canal1.96661200
15MP0004957_abnormal_blastocyst_morpholog1.94150569
16MP0003385_abnormal_body_wall1.93770732
17MP0005257_abnormal_intraocular_pressure1.86308657
18MP0003941_abnormal_skin_development1.84641347
19MP0003942_abnormal_urinary_system1.83093485
20* MP0000049_abnormal_middle_ear1.82021591
21MP0000428_abnormal_craniofacial_morphol1.80139787
22MP0004272_abnormal_basement_membrane1.79843749
23MP0005623_abnormal_meninges_morphology1.79581471
24MP0002249_abnormal_larynx_morphology1.78842032
25MP0004264_abnormal_extraembryonic_tissu1.78715158
26* MP0002932_abnormal_joint_morphology1.74263606
27MP0009250_abnormal_appendicular_skeleto1.67365843
28MP0002653_abnormal_ependyma_morphology1.64613735
29MP0001293_anophthalmia1.64310500
30MP0005076_abnormal_cell_differentiation1.57837265
31MP0000566_synostosis1.57400845
32* MP0005508_abnormal_skeleton_morphology1.57166428
33MP0004197_abnormal_fetal_growth/weight/1.56597228
34MP0000537_abnormal_urethra_morphology1.56254549
35* MP0002085_abnormal_embryonic_tissue1.56041578
36MP0002084_abnormal_developmental_patter1.55553557
37* MP0003935_abnormal_craniofacial_develop1.55029223
38MP0005380_embryogenesis_phenotype1.51488681
39MP0001672_abnormal_embryogenesis/_devel1.51488681
40MP0009379_abnormal_foot_pigmentation1.50867972
41* MP0003755_abnormal_palate_morphology1.49036037
42MP0000534_abnormal_ureter_morphology1.46954770
43* MP0003937_abnormal_limbs/digits/tail_de1.46182264
44MP0006054_spinal_hemorrhage1.45925923
45MP0003279_aneurysm1.44635404
46MP0000762_abnormal_tongue_morphology1.43223592
47MP0004233_abnormal_muscle_weight1.43156185
48MP0004133_heterotaxia1.38153211
49MP0002088_abnormal_embryonic_growth/wei1.37820891
50MP0003984_embryonic_growth_retardation1.36942536
51* MP0000432_abnormal_head_morphology1.35941530
52* MP0002116_abnormal_craniofacial_bone1.34339188
53MP0002938_white_spotting1.33789141
54MP0001849_ear_inflammation1.33604578
55MP0001299_abnormal_eye_distance/1.30908042
56* MP0002111_abnormal_tail_morphology1.29430889
57MP0008057_abnormal_DNA_replication1.29318497
58* MP0002114_abnormal_axial_skeleton1.28287492
59MP0002877_abnormal_melanocyte_morpholog1.27580515
60MP0006292_abnormal_olfactory_placode1.27475049
61MP0005367_renal/urinary_system_phenotyp1.26240803
62MP0000516_abnormal_urinary_system1.26240803
63MP0002086_abnormal_extraembryonic_tissu1.25309928
64MP0008004_abnormal_stomach_pH1.23878630
65MP0008932_abnormal_embryonic_tissue1.22556634
66MP0001730_embryonic_growth_arrest1.21951051
67* MP0001697_abnormal_embryo_size1.20200808
68MP0003077_abnormal_cell_cycle1.19176671
69MP0000350_abnormal_cell_proliferation1.18717669
70MP0003566_abnormal_cell_adhesion1.16514832
71MP0002282_abnormal_trachea_morphology1.14733301
72* MP0002233_abnormal_nose_morphology1.12449820
73* MP0000163_abnormal_cartilage_morphology1.11947645
74MP0003115_abnormal_respiratory_system1.11263012
75MP0002092_abnormal_eye_morphology1.11084959
76MP0005248_abnormal_Harderian_gland1.10013709
77MP0003693_abnormal_embryo_hatching1.09562928
78MP0005394_taste/olfaction_phenotype1.08344818
79MP0005499_abnormal_olfactory_system1.08344818
80MP0003111_abnormal_nucleus_morphology1.07994341
81MP0002254_reproductive_system_inflammat1.07918156
82MP0003861_abnormal_nervous_system1.07889534
83MP0004858_abnormal_nervous_system1.07279428
84MP0002108_abnormal_muscle_morphology1.07180918
85* MP0002109_abnormal_limb_morphology1.06272407
86MP0003567_abnormal_fetal_cardiomyocyte1.06176072
87MP0002697_abnormal_eye_size1.03404082
88* MP0009703_decreased_birth_body1.03013909
89MP0005023_abnormal_wound_healing1.02808160
90MP0002127_abnormal_cardiovascular_syste1.02793622
91MP0008007_abnormal_cellular_replicative1.00804557
92MP0001286_abnormal_eye_development1.00738389
93MP0001958_emphysema1.00042579
94MP0002925_abnormal_cardiovascular_devel0.99297288
95MP0002080_prenatal_lethality0.97237727
96MP0005197_abnormal_uvea_morphology0.94734246
97MP0000462_abnormal_digestive_system0.93117129
98MP0010094_abnormal_chromosome_stability0.91913717
99MP0000733_abnormal_muscle_development0.91710344
100MP0003315_abnormal_perineum_morphology0.90555638
101MP0009672_abnormal_birth_weight0.87304185
102MP0008789_abnormal_olfactory_epithelium0.87093907
103MP0003938_abnormal_ear_development0.85941625
104MP0002060_abnormal_skin_morphology0.83330677
105MP0002751_abnormal_autonomic_nervous0.83137854
106MP0005391_vision/eye_phenotype0.82716899
107MP0000767_abnormal_smooth_muscle0.82338229
108* MP0002115_abnormal_skeleton_extremities0.81198949
109* MP0002896_abnormal_bone_mineralization0.78391572
110MP0001346_abnormal_lacrimal_gland0.78027614
111MP0009384_cardiac_valve_regurgitation0.78012435
112MP0000579_abnormal_nail_morphology0.77393386
113* MP0002081_perinatal_lethality0.75451945
114MP0005193_abnormal_anterior_eye0.71033639
115MP0001661_extended_life_span0.70307800
116MP0000751_myopathy0.70237774

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.41733956
2Hepatoblastoma (HP:0002884)3.84018288
3Premature rupture of membranes (HP:0001788)3.80310098
4Bilateral microphthalmos (HP:0007633)3.44095691
5Shallow orbits (HP:0000586)3.10944032
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.01715495
7Short 4th metacarpal (HP:0010044)3.01715495
8Anophthalmia (HP:0000528)2.92830621
9Ependymoma (HP:0002888)2.91427877
10* Renal duplication (HP:0000075)2.79124478
11Selective tooth agenesis (HP:0001592)2.75483912
12Ankle contracture (HP:0006466)2.72665068
13Short humerus (HP:0005792)2.68038015
14Aplasia/hypoplasia of the humerus (HP:0006507)2.64922408
15Abdominal situs inversus (HP:0003363)2.62223529
16Abnormality of abdominal situs (HP:0011620)2.62223529
17Abnormality of the phalanges of the hallux (HP:0010057)2.57426421
18Reticulocytopenia (HP:0001896)2.54608488
19Abnormality of the distal phalanx of the thumb (HP:0009617)2.51867829
20Vitreoretinal degeneration (HP:0000655)2.44534489
21Duplication of thumb phalanx (HP:0009942)2.44352932
22Bladder diverticulum (HP:0000015)2.44064307
23Abnormality of the 4th metacarpal (HP:0010012)2.43714817
24Abnormality of the phalanges of the 2nd finger (HP:0009541)2.41536421
25Patent foramen ovale (HP:0001655)2.40878862
26Abnormality of dentin (HP:0010299)2.39529223
27Abnormality of the calcaneus (HP:0008364)2.37348440
28Abnormality of the ischium (HP:0003174)2.35901502
29Mildly elevated creatine phosphokinase (HP:0008180)2.35362786
30Rectal fistula (HP:0100590)2.34973070
31Rectovaginal fistula (HP:0000143)2.34973070
32Fused cervical vertebrae (HP:0002949)2.33655376
33* Rib fusion (HP:0000902)2.33515760
34Thin ribs (HP:0000883)2.32780233
35Double outlet right ventricle (HP:0001719)2.32707502
36Congenital malformation of the right heart (HP:0011723)2.32707502
37Nephroblastoma (Wilms tumor) (HP:0002667)2.30056178
38Partial duplication of the phalanx of hand (HP:0009999)2.29832269
39Abnormality of the astrocytes (HP:0100707)2.29790728
40Astrocytoma (HP:0009592)2.29790728
41Abnormality of the fetal cardiovascular system (HP:0010948)2.27572460
42Abnormal umbilical cord blood vessels (HP:0011403)2.27572460
43Single umbilical artery (HP:0001195)2.27572460
44Soft skin (HP:0000977)2.25449849
45Abnormality of the parietal bone (HP:0002696)2.23415629
46Embryonal renal neoplasm (HP:0011794)2.23295048
47Neonatal short-limb short stature (HP:0008921)2.20488413
48Cerebral aneurysm (HP:0004944)2.19788421
49High anterior hairline (HP:0009890)2.19721774
50Midline defect of the nose (HP:0004122)2.19550974
51Hyperinsulinemic hypoglycemia (HP:0000825)2.18898978
52Shawl scrotum (HP:0000049)2.18253445
53Chin dimple (HP:0010751)2.17731020
54Ulnar bowing (HP:0003031)2.16987976
55Anal stenosis (HP:0002025)2.16446149
56Multiple enchondromatosis (HP:0005701)2.15911920
57Intestinal fistula (HP:0100819)2.15462957
58Neoplasm of striated muscle (HP:0009728)2.15414224
59Trismus (HP:0000211)2.14966487
60Abnormality of the aortic arch (HP:0012303)2.12854553
61Hypoplastic pelvis (HP:0008839)2.11139062
62Broad palm (HP:0001169)2.11136087
63Cervical subluxation (HP:0003308)2.10517856
64Atrophic scars (HP:0001075)2.10161956
65* Broad thumb (HP:0011304)2.07941292
66Transposition of the great arteries (HP:0001669)2.07193655
67Abnormal connection of the cardiac segments (HP:0011545)2.07193655
68Abnormal ventriculo-arterial connection (HP:0011563)2.07193655
69Genu recurvatum (HP:0002816)2.07055951
70Irregular epiphyses (HP:0010582)2.06539126
71Mitral valve prolapse (HP:0001634)2.05716512
72Aortic aneurysm (HP:0004942)2.03974502
73Vaginal fistula (HP:0004320)2.01962100
74Neoplasm of the heart (HP:0100544)2.00514372
75Peritonitis (HP:0002586)1.99555442
76Atresia of the external auditory canal (HP:0000413)1.99381206
77Absent frontal sinuses (HP:0002688)1.99136838
78Calcaneovalgus deformity (HP:0001848)1.97699297
79Pancreatic islet-cell hyperplasia (HP:0004510)1.96485057
80Bowel diverticulosis (HP:0005222)1.96356039
81Fragile skin (HP:0001030)1.95780739
82Abnormality of the pubic bones (HP:0003172)1.95744035
83Coronal craniosynostosis (HP:0004440)1.95190636
84Supernumerary ribs (HP:0005815)1.94349395
85Hypoplastic ischia (HP:0003175)1.94001500
86Preauricular skin tag (HP:0000384)1.93225697
87* Short 5th finger (HP:0009237)1.92044647
88* Wide anterior fontanel (HP:0000260)1.91668376
89Abnormality of the 2nd finger (HP:0004100)1.90609255
90Increased connective tissue (HP:0009025)1.90552956
91* Broad long bones (HP:0005622)1.89523547
92Supernumerary spleens (HP:0009799)1.88641796
93Skin tags (HP:0010609)1.88495811
94* Broad toe (HP:0001837)1.88472628
95Glioma (HP:0009733)1.88109796
96Broad metatarsal (HP:0001783)1.86510421
97Deviation of the hallux (HP:0010051)1.85313554
98Bell-shaped thorax (HP:0001591)1.84365525
99* Broad phalanges of the hand (HP:0009768)1.84349269
100Aortic dissection (HP:0002647)1.83883671
101Abnormal lung lobation (HP:0002101)1.83075656
102Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82047527
103Ectopic kidney (HP:0000086)1.81194265
104Myelomeningocele (HP:0002475)1.79884133
105Turricephaly (HP:0000262)1.79552097
106Rhabdomyosarcoma (HP:0002859)1.79341634
107Disproportionate tall stature (HP:0001519)1.79065525
108Absent radius (HP:0003974)1.78323051
109Aplasia/Hypoplasia of the sternum (HP:0006714)1.77012116
110Medulloblastoma (HP:0002885)1.76964444
111* Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.76260277
112* Missing ribs (HP:0000921)1.75318417
113Cupped ribs (HP:0000887)1.75067326
114Colon cancer (HP:0003003)1.75010146
115* Broad phalanx (HP:0006009)1.74898594
116Hallux valgus (HP:0001822)1.74814381
117Skin pits (HP:0100276)1.74484018
118Supernumerary bones of the axial skeleton (HP:0009144)1.74207343
119Abnormal pancreas size (HP:0012094)1.73545341
120Chromsome breakage (HP:0040012)1.73073915
121Periauricular skin pits (HP:0100277)1.72900425
122Preauricular pit (HP:0004467)1.72900425
123* Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.71824585
124Joint laxity (HP:0001388)1.71149484
125* Bifid tongue (HP:0010297)1.70703799
126Increased nuchal translucency (HP:0010880)1.70216025
127* Broad finger (HP:0001500)1.70061193
128Short phalanx of the thumb (HP:0009660)1.69959501
129Deformed tarsal bones (HP:0008119)1.69513950
130Dilatation of the ascending aorta (HP:0005111)1.69463953
131Facial cleft (HP:0002006)1.69237489
132Mild short stature (HP:0003502)1.68667939
133* Blue sclerae (HP:0000592)1.68210325
134Morphological abnormality of the middle ear (HP:0008609)1.67912173
135Delayed epiphyseal ossification (HP:0002663)1.67837676
136Infantile muscular hypotonia (HP:0008947)1.67471619
137Abnormality of the umbilical cord (HP:0010881)1.66552589
138* Cutaneous syndactyly (HP:0012725)1.66420104
139Diastasis recti (HP:0001540)1.65885758
140Neoplasm of the oral cavity (HP:0100649)1.65010850
141Rectal prolapse (HP:0002035)1.65004128
142Spinal rigidity (HP:0003306)1.64941078
143* Cutaneous finger syndactyly (HP:0010554)1.64634994
144Mixed hearing impairment (HP:0000410)1.64556332
145Abnormal vertebral ossification (HP:0100569)1.64124310
146Dislocated radial head (HP:0003083)1.62939957
147Short hallux (HP:0010109)1.62865628
148Metaphyseal cupping (HP:0003021)1.62625178
149Biconcave vertebral bodies (HP:0004586)1.62599357
150* Vertebral fusion (HP:0002948)1.62329241
151Down-sloping shoulders (HP:0200021)1.62113997
152Omphalocele (HP:0001539)1.61229731
153* Preaxial foot polydactyly (HP:0001841)1.61140956
154Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.60956741
155Vertebral hypoplasia (HP:0008417)1.60956741
156Thin bony cortex (HP:0002753)1.59293228
157Abnormal number of incisors (HP:0011064)1.59230775
158Absent forearm bone (HP:0003953)1.58957516
159Aplasia involving forearm bones (HP:0009822)1.58957516
160Ectopia lentis (HP:0001083)1.58906380
161Partial duplication of thumb phalanx (HP:0009944)1.58428867
162Trigonocephaly (HP:0000243)1.57975289
163Abnormality of the middle phalanges of the toes (HP:0010183)1.57927184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.33579939
2ICK2.99991190
3ERN12.96953333
4LATS22.89061889
5DDR22.77648594
6PDGFRA2.61406560
7LATS12.42309207
8PLK42.40306447
9MAP3K102.25457119
10PASK2.23362055
11PBK2.15926938
12EPHA22.15524503
13PDK22.07570989
14TTK1.96370659
15ERBB41.76677919
16CDK71.75766206
17GRK51.66450173
18CDC71.64617721
19TRIB31.64027618
20MYLK1.57006452
21NEK21.56104065
22STK38L1.51716694
23FGFR21.50916855
24PAK41.50795862
25EPHB21.48844252
26SMG11.47350137
27MAP3K61.41517485
28MTOR1.38539873
29TYRO31.36022395
30DMPK1.35177737
31AKT31.32792635
32PTK21.30837940
33PLK11.27753017
34PKN21.26781304
35MAP3K91.19741000
36TTN1.16995066
37MKNK21.16949493
38PRKD31.16208108
39CLK11.15648503
40STK161.15600618
41CASK1.14714936
42PAK21.13162590
43WNK11.12616074
44GRK61.10522183
45FGFR11.09789565
46NME11.08272521
47PTK61.06700852
48HIPK21.05704357
49BUB11.04403496
50RPS6KB21.03792825
51CHEK21.01928541
52BRSK11.01917550
53FLT31.01357207
54BRD40.98688729
55MAPK150.98425657
56BMX0.97730045
57NEK10.96531855
58MET0.93351493
59STK100.93148151
60CAMK1G0.91749765
61PRKCI0.91710951
62TGFBR10.90705209
63NTRK10.90184823
64SIK10.88362844
65CHEK10.87939577
66WNK30.86954769
67CDC42BPA0.86893488
68STK30.86809518
69MKNK10.85416945
70PRKG20.84478177
71TGFBR20.84346062
72PNCK0.82540010
73WEE10.80010313
74BRSK20.79443543
75ALK0.79018881
76MATK0.77967285
77STK40.77232568
78AURKB0.75067770
79RIPK10.74917407
80LRRK20.73781668
81DYRK30.73648484
82MAP3K80.73450977
83PRKD20.72868118
84MAPK70.72759817
85TNIK0.72538890
86DYRK1B0.71454740
87ZAK0.71414889
88BRAF0.71329523
89MAP3K30.71092689
90GRK10.70131182
91ADRBK10.69344899
92SRPK10.68616427
93AURKA0.68209887
94CDK80.67284803
95AKT20.66708452
96CDK20.65900125
97UHMK10.64836999
98PIM20.64657915
99MAP3K40.62434640
100CDK40.60723976
101TAOK20.60374705
102PAK10.60347583
103MAP2K70.59402179
104MELK0.59127086
105RPS6KC10.58531991
106RPS6KL10.58531991
107DAPK30.58453236
108ATM0.58357691
109PLK30.58116898
110MAP3K70.55907131
111PAK30.55823440
112TAF10.55344228
113CAMK1D0.55051704
114CDK60.54524741
115MOS0.54120009
116EPHA40.53402937
117NME20.53319334
118MARK20.53283527
119VRK20.52735528
120RPS6KA20.52490204
121FER0.52138356
122ILK0.52009203
123RPS6KA40.51656704
124CAMK40.50944697
125PDGFRB0.50553022
126ERBB20.50250464
127INSRR0.49275555
128ACVR1B0.48958417
129WNK40.48543737
130ATR0.47601381
131NLK0.47437158
132SCYL20.46649637
133CDK10.46520469
134CSNK1E0.46308682
135ADRBK20.45967984
136TLK10.45911514
137MAPK10.45482423
138RPS6KA60.44948913
139EEF2K0.44467832

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.19147611
2Hedgehog signaling pathway_Homo sapiens_hsa043402.75016944
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59791807
4RNA transport_Homo sapiens_hsa030132.52639015
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.50726910
6Hippo signaling pathway_Homo sapiens_hsa043902.48900311
7Mismatch repair_Homo sapiens_hsa034302.39425721
8DNA replication_Homo sapiens_hsa030302.15713108
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14930216
10Cell cycle_Homo sapiens_hsa041102.14221160
11Spliceosome_Homo sapiens_hsa030402.11254087
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.05043088
13mRNA surveillance pathway_Homo sapiens_hsa030152.03635456
14Adherens junction_Homo sapiens_hsa045202.00590666
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.93378685
16One carbon pool by folate_Homo sapiens_hsa006701.84297634
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.81503684
18TGF-beta signaling pathway_Homo sapiens_hsa043501.79000750
19Protein digestion and absorption_Homo sapiens_hsa049741.77305977
20ECM-receptor interaction_Homo sapiens_hsa045121.73612286
21Bladder cancer_Homo sapiens_hsa052191.63894500
22Base excision repair_Homo sapiens_hsa034101.61969456
23MicroRNAs in cancer_Homo sapiens_hsa052061.61524866
24Thyroid cancer_Homo sapiens_hsa052161.60106451
25Wnt signaling pathway_Homo sapiens_hsa043101.58067856
26mTOR signaling pathway_Homo sapiens_hsa041501.52888594
27Proteoglycans in cancer_Homo sapiens_hsa052051.49110905
28p53 signaling pathway_Homo sapiens_hsa041151.47008503
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46154013
30Ribosome_Homo sapiens_hsa030101.44022935
31Focal adhesion_Homo sapiens_hsa045101.38779943
32Tight junction_Homo sapiens_hsa045301.33940523
33RNA degradation_Homo sapiens_hsa030181.30530733
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26284519
35Notch signaling pathway_Homo sapiens_hsa043301.24478685
36Galactose metabolism_Homo sapiens_hsa000521.22501934
37Fructose and mannose metabolism_Homo sapiens_hsa000511.20841871
38Homologous recombination_Homo sapiens_hsa034401.20649000
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20058558
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19503670
41Steroid biosynthesis_Homo sapiens_hsa001001.16308804
42Pathways in cancer_Homo sapiens_hsa052001.15604059
43Nucleotide excision repair_Homo sapiens_hsa034201.14810551
44Pyruvate metabolism_Homo sapiens_hsa006201.12325501
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.09272368
46Fanconi anemia pathway_Homo sapiens_hsa034601.06886134
47HTLV-I infection_Homo sapiens_hsa051661.02401550
48Small cell lung cancer_Homo sapiens_hsa052221.00950190
49PI3K-Akt signaling pathway_Homo sapiens_hsa041510.98285350
50Selenocompound metabolism_Homo sapiens_hsa004500.96129395
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94780945
52Axon guidance_Homo sapiens_hsa043600.93193613
53Melanogenesis_Homo sapiens_hsa049160.91913239
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91562431
55Protein export_Homo sapiens_hsa030600.90877866
56Colorectal cancer_Homo sapiens_hsa052100.90746905
57Melanoma_Homo sapiens_hsa052180.89905716
58Dilated cardiomyopathy_Homo sapiens_hsa054140.89090692
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87991266
60Prostate cancer_Homo sapiens_hsa052150.85849881
61Lysine degradation_Homo sapiens_hsa003100.84322643
62Oocyte meiosis_Homo sapiens_hsa041140.84087846
63RNA polymerase_Homo sapiens_hsa030200.82993810
64Viral carcinogenesis_Homo sapiens_hsa052030.82947662
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77113220
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76245064
67Endometrial cancer_Homo sapiens_hsa052130.75744134
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75660271
69Chronic myeloid leukemia_Homo sapiens_hsa052200.73561905
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73107739
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71240641
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71097829
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68665072
74Rap1 signaling pathway_Homo sapiens_hsa040150.67592670
75Carbon metabolism_Homo sapiens_hsa012000.67583433
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67289950
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65937524
78Huntingtons disease_Homo sapiens_hsa050160.65240950
79Arachidonic acid metabolism_Homo sapiens_hsa005900.63993240
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.62183658
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62150761
82Glucagon signaling pathway_Homo sapiens_hsa049220.61500475
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61456243
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59617216
85AMPK signaling pathway_Homo sapiens_hsa041520.59243165
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56886095
87Pyrimidine metabolism_Homo sapiens_hsa002400.56073881
88Sulfur relay system_Homo sapiens_hsa041220.54065424
89Basal transcription factors_Homo sapiens_hsa030220.53573909
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52617494
91Insulin resistance_Homo sapiens_hsa049310.52394818
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.51126771
93N-Glycan biosynthesis_Homo sapiens_hsa005100.50475800
94Biosynthesis of amino acids_Homo sapiens_hsa012300.50268371
95Alcoholism_Homo sapiens_hsa050340.50254422
96Purine metabolism_Homo sapiens_hsa002300.49952273
97Amoebiasis_Homo sapiens_hsa051460.49155611
98Glutathione metabolism_Homo sapiens_hsa004800.48435687
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47982514
100Renin-angiotensin system_Homo sapiens_hsa046140.47211477
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.43636451
102Viral myocarditis_Homo sapiens_hsa054160.42233874
103Insulin signaling pathway_Homo sapiens_hsa049100.41211350
104Cardiac muscle contraction_Homo sapiens_hsa042600.39990518
105Glioma_Homo sapiens_hsa052140.39750788
106Pancreatic cancer_Homo sapiens_hsa052120.38566932
107Linoleic acid metabolism_Homo sapiens_hsa005910.38320633
108Thyroid hormone synthesis_Homo sapiens_hsa049180.38312789
109Systemic lupus erythematosus_Homo sapiens_hsa053220.38135899
110Folate biosynthesis_Homo sapiens_hsa007900.37660780
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37504029
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36162961
113Parkinsons disease_Homo sapiens_hsa050120.35189535
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.34656654
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34520837
116Non-homologous end-joining_Homo sapiens_hsa034500.33808387
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.33664895
118Insulin secretion_Homo sapiens_hsa049110.32840788
119Gap junction_Homo sapiens_hsa045400.31907953
120HIF-1 signaling pathway_Homo sapiens_hsa040660.31211060
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30223461
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30132381
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29884395

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