RORA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.47038318
2negative regulation of cell killing (GO:0031342)5.47038318
3negative T cell selection (GO:0043383)5.23364316
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.89587774
5regulation of isotype switching to IgG isotypes (GO:0048302)4.84007119
6negative thymic T cell selection (GO:0045060)4.78704257
7positive T cell selection (GO:0043368)4.28152178
8activated T cell proliferation (GO:0050798)4.16647583
9response to interleukin-15 (GO:0070672)4.16573985
10cellular response to interleukin-15 (GO:0071350)4.15491401
11regulation of gamma-delta T cell differentiation (GO:0045586)4.11777383
12positive regulation of gamma-delta T cell activation (GO:0046645)4.06086564
13tolerance induction (GO:0002507)4.04814822
14regulation of B cell receptor signaling pathway (GO:0050855)4.03227907
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.96981304
16establishment of skin barrier (GO:0061436)3.92341111
17keratinization (GO:0031424)3.87234769
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78623820
19cellular potassium ion homeostasis (GO:0030007)3.77452942
20positive regulation of granulocyte differentiation (GO:0030854)3.74844301
21regulation of gamma-delta T cell activation (GO:0046643)3.70006402
22T cell selection (GO:0045058)3.61254489
23negative regulation of T cell mediated immunity (GO:0002710)3.60945056
24cerebellar granule cell differentiation (GO:0021707)3.59787655
25gamma-aminobutyric acid transport (GO:0015812)3.54891485
26G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.48116075
27thymic T cell selection (GO:0045061)3.34350679
28interferon-gamma production (GO:0032609)3.34072162
29regulation of short-term neuronal synaptic plasticity (GO:0048172)3.32413913
30* alpha-beta T cell differentiation (GO:0046632)3.30887380
31T cell migration (GO:0072678)3.29551152
32phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.26034714
33regulation of regulatory T cell differentiation (GO:0045589)3.24227341
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.24199619
35sodium ion export (GO:0071436)3.23091616
36negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.22732624
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.20804767
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.12761397
39antigen processing and presentation of endogenous antigen (GO:0019883)3.08590015
40negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08327652
41negative regulation of T-helper cell differentiation (GO:0045623)3.08327652
42* CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.05170287
43* T-helper cell differentiation (GO:0042093)3.05170287
44positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.03587957
45neurotransmitter secretion (GO:0007269)3.03135001
46detection of light stimulus involved in sensory perception (GO:0050962)3.01825142
47detection of light stimulus involved in visual perception (GO:0050908)3.01825142
48leukocyte aggregation (GO:0070486)3.01570324
49neuronal action potential propagation (GO:0019227)3.01357192
50positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.01154444
51positive thymic T cell selection (GO:0045059)3.00705426
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.99845033
53retinal cone cell development (GO:0046549)2.98412077
54gamma-aminobutyric acid signaling pathway (GO:0007214)2.98087334
55regulation of energy homeostasis (GO:2000505)2.94467777
56glutamate secretion (GO:0014047)2.93656861
57negative regulation of adaptive immune response (GO:0002820)2.91363935
58regulation of water loss via skin (GO:0033561)2.89828642
59* alpha-beta T cell differentiation involved in immune response (GO:0002293)2.88871990
60* alpha-beta T cell activation involved in immune response (GO:0002287)2.88871990
61* T cell differentiation involved in immune response (GO:0002292)2.88871990
62regulation of alpha-beta T cell proliferation (GO:0046640)2.88672797
63synaptic vesicle exocytosis (GO:0016079)2.88575211
64* alpha-beta T cell activation (GO:0046631)2.85030060
65positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.81536936
66vocalization behavior (GO:0071625)2.81473870
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80874295
68regulation of T cell mediated cytotoxicity (GO:0001914)2.80785090
69positive regulation of tolerance induction (GO:0002645)2.80218018
70positive regulation of alpha-beta T cell proliferation (GO:0046641)2.78394201
71protein K11-linked deubiquitination (GO:0035871)2.76785098
72glutamate receptor signaling pathway (GO:0007215)2.76712098
73* CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.76316920
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.75853742
75L-phenylalanine catabolic process (GO:0006559)2.75853742
76T cell receptor signaling pathway (GO:0050852)2.75054764
77cellular response to ethanol (GO:0071361)2.73779765
78dicarboxylic acid biosynthetic process (GO:0043650)2.73014669
79glutamate metabolic process (GO:0006536)2.72505005
80neurotransmitter-gated ion channel clustering (GO:0072578)2.71457673
81regulation of synaptic vesicle exocytosis (GO:2000300)2.71017864
82negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.70819916
83response to pheromone (GO:0019236)2.69586332
84regulation of germinal center formation (GO:0002634)2.69485175
85regulation of T cell tolerance induction (GO:0002664)2.68818353
86histone H3-K36 demethylation (GO:0070544)2.67618390
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.63830299
88potassium ion homeostasis (GO:0055075)2.60521315
89protein targeting to Golgi (GO:0000042)2.56858038
90locomotory exploration behavior (GO:0035641)2.56372386
91regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.55522911
92regulation of natural killer cell mediated immunity (GO:0002715)2.55522911
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.55454018
94negative regulation of protein oligomerization (GO:0032460)2.54813687
95cellular sodium ion homeostasis (GO:0006883)2.54752508
96retinal rod cell development (GO:0046548)2.54430345
97* T cell differentiation (GO:0030217)2.54415168
98keratinocyte development (GO:0003334)2.52232995
99positive regulation of natural killer cell mediated immunity (GO:0002717)2.51217632
100positive regulation of cardiac muscle hypertrophy (GO:0010613)2.49852005
101positive regulation of muscle hypertrophy (GO:0014742)2.49852005
102antigen receptor-mediated signaling pathway (GO:0050851)2.49452302
103positive regulation of DNA recombination (GO:0045911)2.48907426
104neurotransmitter transport (GO:0006836)2.48809896
105synaptic vesicle maturation (GO:0016188)2.48675382
106regulation of leukocyte mediated cytotoxicity (GO:0001910)2.48193922
107histone H3-K4 trimethylation (GO:0080182)2.48109890
108regulation of T cell receptor signaling pathway (GO:0050856)2.47687372
109glucocorticoid metabolic process (GO:0008211)2.47574613
110ionotropic glutamate receptor signaling pathway (GO:0035235)2.46995357
111positive regulation of T cell mediated cytotoxicity (GO:0001916)2.46962982
112negative regulation of leukocyte mediated immunity (GO:0002704)2.46187683
113mucosal-associated lymphoid tissue development (GO:0048537)2.44240571
114Peyers patch development (GO:0048541)2.44240571
115positive regulation of isotype switching (GO:0045830)2.43063778
116response to histamine (GO:0034776)2.42841855
117regulation of memory T cell differentiation (GO:0043380)2.42036898
118establishment of protein localization to Golgi (GO:0072600)2.41981559
119potassium ion import (GO:0010107)2.41358955
120* cerebellar Purkinje cell differentiation (GO:0021702)2.40951923
121membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40330488
122very-low-density lipoprotein particle assembly (GO:0034379)2.40098947
123regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.39753581
124L-phenylalanine metabolic process (GO:0006558)2.39603157
125erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.39603157
126regulation of interleukin-2 biosynthetic process (GO:0045076)2.39430226
127lymph node development (GO:0048535)2.39326985
128dicarboxylic acid catabolic process (GO:0043649)2.39156794
129regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.38934863
130positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.38675434
131regulation of cell killing (GO:0031341)2.38377277
132regulation of voltage-gated calcium channel activity (GO:1901385)2.37794756
133regulation of bile acid biosynthetic process (GO:0070857)2.35766517
134positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.35393884
135T cell mediated immunity (GO:0002456)2.34754327
136cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.33475682
137regulation of tolerance induction (GO:0002643)2.32868130
138photoreceptor cell development (GO:0042461)2.32786946
139desmosome organization (GO:0002934)2.32422143
140eye photoreceptor cell development (GO:0042462)2.32238276
141cellular response to epinephrine stimulus (GO:0071872)2.31744312
142regulation of synaptic vesicle transport (GO:1902803)2.31446853
143negative regulation of glycoprotein biosynthetic process (GO:0010561)2.31242449
144regulation of calcium-mediated signaling (GO:0050848)2.31002006
145behavioral response to cocaine (GO:0048148)2.30233236
146regulation of interleukin-12 biosynthetic process (GO:0045075)2.30072334
147regulation of granulocyte differentiation (GO:0030852)2.29548822
148regulation of fibroblast apoptotic process (GO:2000269)2.29145975
149positive regulation of cell killing (GO:0031343)2.28954905
150succinate metabolic process (GO:0006105)2.28730625
151RNA destabilization (GO:0050779)2.28659356
152peptidyl-glutamic acid carboxylation (GO:0017187)2.28100709
153protein carboxylation (GO:0018214)2.28100709
154regulation of neurotransmitter levels (GO:0001505)2.27910365
155positive regulation of fatty acid beta-oxidation (GO:0032000)2.27680365
156* CD4-positive, alpha-beta T cell activation (GO:0035710)2.27509578
157positive regulation of humoral immune response (GO:0002922)2.27416503
158regulation of clathrin-mediated endocytosis (GO:2000369)2.26813602
159triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.26236081
160phospholipid efflux (GO:0033700)2.26235225
161* cell differentiation in hindbrain (GO:0021533)2.25510490
162long term synaptic depression (GO:0060292)2.25416013
163aromatic amino acid family catabolic process (GO:0009074)2.25234003
164neuron-neuron synaptic transmission (GO:0007270)2.25022085
165rhodopsin mediated signaling pathway (GO:0016056)2.22922658
166regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.21333576
167protein localization to synapse (GO:0035418)2.20645311
168synaptic transmission, glutamatergic (GO:0035249)2.18821209
169relaxation of cardiac muscle (GO:0055119)2.18516420
170retrograde transport, vesicle recycling within Golgi (GO:0000301)2.17326708
171high-density lipoprotein particle remodeling (GO:0034375)2.14728169
172bile acid biosynthetic process (GO:0006699)2.14076866
173regulation of activation of Janus kinase activity (GO:0010533)2.13339608
174negative regulation of protein activation cascade (GO:2000258)2.12616493
175regulation of glutamate receptor signaling pathway (GO:1900449)2.11549904
176mating behavior (GO:0007617)2.09897834
177plasma lipoprotein particle assembly (GO:0034377)2.09667509
178alpha-linolenic acid metabolic process (GO:0036109)2.08280878
179regulation of ARF protein signal transduction (GO:0032012)2.07501699
180negative regulation of lipase activity (GO:0060192)2.07191705
181regulation of vesicle fusion (GO:0031338)2.06549830
182regulation of protein activation cascade (GO:2000257)2.05850215
183peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.05220693
184long-term memory (GO:0007616)2.05009690
185regulation of synaptic transmission, glutamatergic (GO:0051966)2.04789011
186negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.03771215
187negative regulation of synaptic transmission, GABAergic (GO:0032229)2.03221394
188regulation of postsynaptic membrane potential (GO:0060078)2.02893510
189long-term synaptic potentiation (GO:0060291)2.02666886
190regulation of rhodopsin mediated signaling pathway (GO:0022400)2.02261326
191protein-chromophore linkage (GO:0018298)2.01598319
192neuromuscular process controlling posture (GO:0050884)2.01531582
193negative regulation of cytosolic calcium ion concentration (GO:0051481)2.01334727
194regulation of excitatory postsynaptic membrane potential (GO:0060079)2.00941579
195linoleic acid metabolic process (GO:0043651)2.00564311
196detection of calcium ion (GO:0005513)1.99644190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human2.78911892
2GBX2_23144817_ChIP-Seq_PC3_Human2.50186529
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36169159
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30380957
5EZH2_22144423_ChIP-Seq_EOC_Human2.25486869
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.21722505
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17620076
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05607940
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05553074
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.04923414
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.03014441
12JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92756141
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88436170
14AR_21572438_ChIP-Seq_LNCaP_Human1.87803940
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87362388
16* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83412311
17* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83412311
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83283278
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81619342
20DROSHA_22980978_ChIP-Seq_HELA_Human1.81484528
21RXR_22158963_ChIP-Seq_LIVER_Mouse1.78949840
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78817005
23* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77665060
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.76339764
25* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74230295
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72847935
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72481764
28LXR_22158963_ChIP-Seq_LIVER_Mouse1.70806123
29* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68589020
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.67439880
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.64761696
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.62511293
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61473163
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56571377
35TAF15_26573619_Chip-Seq_HEK293_Human1.53733209
36MYB_26560356_Chip-Seq_TH2_Human1.53617424
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53573336
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52264719
39* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51126356
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.49263013
41SMAD4_21799915_ChIP-Seq_A2780_Human1.48715205
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47840725
43VDR_22108803_ChIP-Seq_LS180_Human1.47767425
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45721249
45* RNF2_27304074_Chip-Seq_ESCs_Mouse1.45113060
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.40126031
47* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39098744
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36434531
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35499924
50* BCAT_22108803_ChIP-Seq_LS180_Human1.35208674
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35176680
52GATA3_27048872_Chip-Seq_THYMUS_Human1.33029472
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31989164
54* REST_21632747_ChIP-Seq_MESCs_Mouse1.31017732
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30068892
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.29590906
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29264958
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.28101574
59* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27716959
60* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27712934
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27233599
62* AR_25329375_ChIP-Seq_VCAP_Human1.25877463
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25292074
64* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25057480
65P300_19829295_ChIP-Seq_ESCs_Human1.24097749
66* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22351798
67ER_23166858_ChIP-Seq_MCF-7_Human1.22301173
68* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21386069
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21142100
70* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20619039
71VDR_24787735_ChIP-Seq_THP-1_Human1.19868750
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18881891
73OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17168785
74GATA3_26560356_Chip-Seq_TH2_Human1.17105488
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16578870
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16245042
77AHR_22903824_ChIP-Seq_MCF-7_Human1.13800769
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.13797855
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.13755501
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.13716328
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13694566
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13365487
83RXR_22108803_ChIP-Seq_LS180_Human1.10758072
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09060093
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.08739798
86IRF8_27001747_Chip-Seq_BMDM_Mouse1.08326244
87TP63_23658742_ChIP-Seq_EP156T_Human1.08096739
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.07838341
89* SMAD3_21741376_ChIP-Seq_EPCs_Human1.07796863
90* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07566381
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06756736
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06756736
93MYB_26560356_Chip-Seq_TH1_Human1.05938810
94FUS_26573619_Chip-Seq_HEK293_Human1.05816083
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05650480
96* RARB_27405468_Chip-Seq_BRAIN_Mouse1.05555202
97* REST_18959480_ChIP-ChIP_MESCs_Mouse1.04232578
98* STAT3_23295773_ChIP-Seq_U87_Human1.04180480
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.04173856
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03826058
101* SOX2_21211035_ChIP-Seq_LN229_Gbm1.02831810
102P53_22387025_ChIP-Seq_ESCs_Mouse1.02828064
103GATA1_22025678_ChIP-Seq_K562_Human1.02101106
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01301771
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00941045
106* AR_19668381_ChIP-Seq_PC3_Human1.00738136
107* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00666895
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99852664
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99467621
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98157485
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97926166
112EP300_21415370_ChIP-Seq_HL-1_Mouse0.97693256
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.96917354
114TP53_16413492_ChIP-PET_HCT116_Human0.96875685
115* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95841234
116SCL_19346495_ChIP-Seq_HPC-7_Human0.95204175
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95150010
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.95149353
119TCF4_18268006_ChIP-ChIP_LS174T_Human0.94524464
120IGF1R_20145208_ChIP-Seq_DFB_Human0.94043975
121* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93730692
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.93255225
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92798102
124* TP53_18474530_ChIP-ChIP_U2OS_Human0.92665791
125TP63_17297297_ChIP-ChIP_HaCaT_Human0.92414174
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92090547
127* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91393937
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90514813
129EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90200405
130* CDX2_22108803_ChIP-Seq_LS180_Human0.90196359
131CMYC_18555785_Chip-Seq_ESCs_Mouse0.90168028
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89580614
133MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89460367
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88939624
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88741404
136TCF4_22108803_ChIP-Seq_LS180_Human0.88075535
137PRDM14_20953172_ChIP-Seq_ESCs_Human0.88059080
138TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87785992
139ESR2_21235772_ChIP-Seq_MCF-7_Human0.87338231
140* FOXA2_19822575_ChIP-Seq_HepG2_Human0.87266126
141TCF4_23295773_ChIP-Seq_U87_Human0.87113870
142* RUNX_20019798_ChIP-Seq_JUKART_Human0.85626066
143PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84717575
144RING1B_27294783_Chip-Seq_ESCs_Mouse0.84689272
145* SMAD4_21741376_ChIP-Seq_EPCs_Human0.84236921
146* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83517276
147ERG_21242973_ChIP-ChIP_JURKAT_Human0.82476637
148CLOCK_20551151_ChIP-Seq_293T_Human0.81860257
149RUNX2_22187159_ChIP-Seq_PCA_Human0.81774267

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.24770788
2MP0005671_abnormal_response_to3.68593011
3MP0005551_abnormal_eye_electrophysiolog3.37448722
4MP0009046_muscle_twitch3.01878622
5MP0002139_abnormal_hepatobiliary_system2.95656429
6MP0005365_abnormal_bile_salt2.79401831
7MP0005360_urolithiasis2.72931603
8MP0006082_CNS_inflammation2.65189751
9MP0003724_increased_susceptibility_to2.58466125
10MP0001501_abnormal_sleep_pattern2.47707753
11MP0004859_abnormal_synaptic_plasticity2.46008400
12MP0003011_delayed_dark_adaptation2.43288158
13MP0001502_abnormal_circadian_rhythm2.43086397
14MP0000569_abnormal_digit_pigmentation2.36629493
15MP0003880_abnormal_central_pattern2.36283465
16MP0001873_stomach_inflammation2.30937767
17MP0008875_abnormal_xenobiotic_pharmacok2.30915739
18* MP0001800_abnormal_humoral_immune2.29268767
19MP0005085_abnormal_gallbladder_physiolo2.28012469
20* MP0003635_abnormal_synaptic_transmissio2.25965259
21MP0002090_abnormal_vision2.22717784
22MP0009745_abnormal_behavioral_response2.10678642
23MP0002166_altered_tumor_susceptibility2.05227676
24MP0002796_impaired_skin_barrier2.05053883
25MP0002064_seizures2.04874072
26MP0005423_abnormal_somatic_nervous2.02416402
27MP0001835_abnormal_antigen_presentation1.90347580
28MP0006072_abnormal_retinal_apoptosis1.88747306
29MP0002272_abnormal_nervous_system1.87144819
30MP0000685_abnormal_immune_system1.85945416
31MP0005000_abnormal_immune_tolerance1.85408693
32MP0009333_abnormal_splenocyte_physiolog1.84546997
33MP0002254_reproductive_system_inflammat1.78950397
34MP0010234_abnormal_vibrissa_follicle1.77500259
35* MP0002723_abnormal_immune_serum1.72491113
36MP0003252_abnormal_bile_duct1.70998767
37MP0003436_decreased_susceptibility_to1.67668056
38MP0005253_abnormal_eye_physiology1.66938428
39MP0000465_gastrointestinal_hemorrhage1.66210085
40MP0002909_abnormal_adrenal_gland1.65275414
41* MP0010329_abnormal_lipoprotein_level1.65033725
42* MP0001790_abnormal_immune_system1.64471653
43* MP0005387_immune_system_phenotype1.64471653
44MP0002933_joint_inflammation1.61481582
45MP0001486_abnormal_startle_reflex1.60526631
46MP0000013_abnormal_adipose_tissue1.60408220
47MP0004145_abnormal_muscle_electrophysio1.60137008
48* MP0002420_abnormal_adaptive_immunity1.59039882
49MP0009780_abnormal_chondrocyte_physiolo1.58565531
50MP0009785_altered_susceptibility_to1.56369033
51* MP0001819_abnormal_immune_cell1.54674091
52* MP0002063_abnormal_learning/memory/cond1.53227382
53MP0002572_abnormal_emotion/affect_behav1.51147049
54* MP0008569_lethality_at_weaning1.50377677
55MP0004270_analgesia1.50163648
56MP0003329_amyloid_beta_deposits1.43625528
57MP0001968_abnormal_touch/_nociception1.41286907
58* MP0002067_abnormal_sensory_capabilities1.40894948
59MP0004019_abnormal_vitamin_homeostasis1.40574008
60MP0003866_abnormal_defecation1.40347254
61MP0005025_abnormal_response_to1.39901616
62MP0003646_muscle_fatigue1.37494156
63MP0001440_abnormal_grooming_behavior1.37127398
64* MP0000703_abnormal_thymus_morphology1.33617688
65* MP0001984_abnormal_olfaction1.33279304
66* MP0002452_abnormal_antigen_presenting1.33185547
67MP0005083_abnormal_biliary_tract1.28392375
68* MP0002405_respiratory_system_inflammati1.27348696
69MP0003195_calcinosis1.25730610
70MP0004885_abnormal_endolymph1.25646162
71MP0002734_abnormal_mechanical_nocicepti1.25131453
72MP0004381_abnormal_hair_follicle1.21201637
73MP0002009_preneoplasia1.21048457
74MP0004883_abnormal_blood_vessel1.20354519
75MP0002398_abnormal_bone_marrow1.20287693
76MP0000372_irregular_coat_pigmentation1.20207357
77MP0005075_abnormal_melanosome_morpholog1.19310386
78MP0003868_abnormal_feces_composition1.19168690
79MP0001348_abnormal_lacrimal_gland1.18758819
80MP0000716_abnormal_immune_system1.17323477
81MP0001986_abnormal_taste_sensitivity1.15345839
82MP0001188_hyperpigmentation1.14931507
83MP0000015_abnormal_ear_pigmentation1.14877225
84MP0002638_abnormal_pupillary_reflex1.12691505
85MP0005174_abnormal_tail_pigmentation1.12631725
86MP0002822_catalepsy1.12376251
87MP0005646_abnormal_pituitary_gland1.11509650
88MP0010155_abnormal_intestine_physiology1.11269610
89MP0005275_abnormal_skin_tensile1.10865441
90* MP0002118_abnormal_lipid_homeostasis1.10313031
91MP0003633_abnormal_nervous_system1.09706263
92MP0005310_abnormal_salivary_gland1.08575244
93MP0002876_abnormal_thyroid_physiology1.08095037
94MP0003690_abnormal_glial_cell1.07332623
95MP0005535_abnormal_body_temperature1.07190837
96MP0002837_dystrophic_cardiac_calcinosis1.06123918
97MP0003879_abnormal_hair_cell1.06046676
98MP0002060_abnormal_skin_morphology1.04709202
99MP0002998_abnormal_bone_remodeling1.04215651
100MP0005332_abnormal_amino_acid1.03585848
101* MP0002229_neurodegeneration1.03444731
102MP0002006_tumorigenesis1.02841803
103MP0002184_abnormal_innervation1.02818372
104* MP0002419_abnormal_innate_immunity1.01632351
105* MP0000689_abnormal_spleen_morphology1.01154306
106* MP0002722_abnormal_immune_system0.98459600
107MP0008961_abnormal_basal_metabolism0.97892811
108MP0000604_amyloidosis0.96385597
109MP0001666_abnormal_nutrient_absorption0.96129328
110* MP0002557_abnormal_social/conspecific_i0.96102135
111MP0010386_abnormal_urinary_bladder0.93861842
112MP0003045_fibrosis0.93406086
113MP0004130_abnormal_muscle_cell0.92848854
114MP0001881_abnormal_mammary_gland0.92277084
115MP0005386_behavior/neurological_phenoty0.92073845
116MP0004924_abnormal_behavior0.92073845
117MP0003787_abnormal_imprinting0.91770748
118MP0000427_abnormal_hair_cycle0.91223761
119MP0005195_abnormal_posterior_eye0.90294240
120MP0001853_heart_inflammation0.89030322
121MP0001765_abnormal_ion_homeostasis0.86743315
122MP0001845_abnormal_inflammatory_respons0.85995070
123MP0002332_abnormal_exercise_endurance0.85348477
124MP0008874_decreased_physiological_sensi0.84997492
125MP0004742_abnormal_vestibular_system0.84210332
126MP0004036_abnormal_muscle_relaxation0.83673473
127MP0000579_abnormal_nail_morphology0.83530176
128MP0001177_atelectasis0.83230799
129MP0003638_abnormal_response/metabolism_0.83148941
130MP0004142_abnormal_muscle_tone0.81483338
131MP0003950_abnormal_plasma_membrane0.81041968
132MP0003828_pulmonary_edema0.80072859
133MP0004947_skin_inflammation0.80039993
134MP0000609_abnormal_liver_physiology0.78365616
135MP0005501_abnormal_skin_physiology0.78288701
136MP0002138_abnormal_hepatobiliary_system0.78280100
137MP0004215_abnormal_myocardial_fiber0.76976855
138MP0004782_abnormal_surfactant_physiolog0.76778274
139MP0009384_cardiac_valve_regurgitation0.76309222
140MP0001851_eye_inflammation0.75168334
141MP0001533_abnormal_skeleton_physiology0.74201891
142MP0002148_abnormal_hypersensitivity_rea0.73121503
143MP0005379_endocrine/exocrine_gland_phen0.71954095
144MP0005584_abnormal_enzyme/coenzyme_acti0.71233076
145MP0004043_abnormal_pH_regulation0.71190775
146MP0003631_nervous_system_phenotype0.71067752
147MP0002066_abnormal_motor_capabilities/c0.69495099
148MP0003191_abnormal_cellular_cholesterol0.69366970
149MP0002095_abnormal_skin_pigmentation0.69221415
150MP0003300_gastrointestinal_ulcer0.68804125
151MP0010771_integument_phenotype0.68380421
152MP0002971_abnormal_brown_adipose0.68249285
153MP0004484_altered_response_of0.66995654
154MP0002429_abnormal_blood_cell0.66754938
155MP0002078_abnormal_glucose_homeostasis0.66139383
156MP0002736_abnormal_nociception_after0.65872543
157MP0001970_abnormal_pain_threshold0.65532302
158* MP0005620_abnormal_muscle_contractility0.65381012

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.95749549
2T lymphocytopenia (HP:0005403)5.15792380
3Abnormality of T cell number (HP:0011839)5.00577073
4Focal motor seizures (HP:0011153)4.65700194
5Stomatitis (HP:0010280)4.62801799
6Eczematoid dermatitis (HP:0000976)4.39403961
7Abnormality of secondary sexual hair (HP:0009888)4.28727574
8Abnormality of the axillary hair (HP:0100134)4.28727574
9Increased IgE level (HP:0003212)4.12390041
10Progressive cerebellar ataxia (HP:0002073)4.00327005
11Abnormality of macular pigmentation (HP:0008002)3.97778775
12Febrile seizures (HP:0002373)3.71154356
13Atonic seizures (HP:0010819)3.63104625
14Dysdiadochokinesis (HP:0002075)3.57205820
15Absence seizures (HP:0002121)3.53905863
16Pigmentary retinal degeneration (HP:0001146)3.50013576
17Central scotoma (HP:0000603)3.41869429
18Abnormality of T cells (HP:0002843)3.30427140
19Scanning speech (HP:0002168)3.29209645
20Epileptic encephalopathy (HP:0200134)3.21066581
21Pustule (HP:0200039)3.14954148
22Bony spicule pigmentary retinopathy (HP:0007737)3.14516005
23IgG deficiency (HP:0004315)3.11904680
24Hyperventilation (HP:0002883)3.10715569
25Dysmetric saccades (HP:0000641)3.08242064
26Autoimmune hemolytic anemia (HP:0001890)3.07572008
27Xanthomatosis (HP:0000991)3.07250050
28Deep venous thrombosis (HP:0002625)2.98632682
29Focal seizures (HP:0007359)2.98325237
30Hyperlipoproteinemia (HP:0010980)2.98286205
31Action tremor (HP:0002345)2.95602350
32Exercise-induced myalgia (HP:0003738)2.95438524
33Visual hallucinations (HP:0002367)2.92874405
34Papilledema (HP:0001085)2.90741513
35Intrahepatic cholestasis (HP:0001406)2.90184698
36Chorioretinal atrophy (HP:0000533)2.89064434
37Decreased central vision (HP:0007663)2.87391338
38Dialeptic seizures (HP:0011146)2.83186522
39Genetic anticipation (HP:0003743)2.82773065
40Abnormal rod and cone electroretinograms (HP:0008323)2.79385516
41Gaze-evoked nystagmus (HP:0000640)2.79179596
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.76517704
43Retrobulbar optic neuritis (HP:0100654)2.75356330
44Optic neuritis (HP:0100653)2.75356330
45Hypotrichosis (HP:0001006)2.73375530
46Stomach cancer (HP:0012126)2.71811631
47Status epilepticus (HP:0002133)2.71091420
48Chronic mucocutaneous candidiasis (HP:0002728)2.69903853
49Recurrent cutaneous fungal infections (HP:0011370)2.69903853
50Spontaneous hematomas (HP:0007420)2.69010848
51Hemiplegia (HP:0002301)2.67311746
52Myositis (HP:0100614)2.65620400
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.65313205
54Prolonged partial thromboplastin time (HP:0003645)2.64342774
55Generalized tonic-clonic seizures (HP:0002069)2.60885112
56Joint swelling (HP:0001386)2.59372836
57Intention tremor (HP:0002080)2.58968151
58Severe combined immunodeficiency (HP:0004430)2.56488518
59Recurrent bronchitis (HP:0002837)2.56216900
60Hypoalphalipoproteinemia (HP:0003233)2.54143986
61Hyperkalemia (HP:0002153)2.53414052
62Recurrent fungal infections (HP:0002841)2.52982048
63Scotoma (HP:0000575)2.52346607
64Erythroderma (HP:0001019)2.52276633
65Gastrointestinal infarctions (HP:0005244)2.51874778
66Recurrent skin infections (HP:0001581)2.50702871
67Abnormality of eosinophils (HP:0001879)2.49208517
68Generalized hypopigmentation of hair (HP:0011358)2.41760590
69Hyporeflexia of lower limbs (HP:0002600)2.40778644
70Thyroiditis (HP:0100646)2.39957054
71Truncal ataxia (HP:0002078)2.37873637
72Ketoacidosis (HP:0001993)2.37342510
73Elevated erythrocyte sedimentation rate (HP:0003565)2.37336925
74Dyschromatopsia (HP:0007641)2.36615211
75Diplopia (HP:0000651)2.35654031
76Abnormality of binocular vision (HP:0011514)2.35654031
77Chronic diarrhea (HP:0002028)2.30258935
78Complement deficiency (HP:0004431)2.30251204
79Ketosis (HP:0001946)2.29270334
80Abnormality of the common coagulation pathway (HP:0010990)2.27641307
81Orchitis (HP:0100796)2.27258730
82Broad-based gait (HP:0002136)2.25374060
83Macular degeneration (HP:0000608)2.25294037
84Erythema (HP:0010783)2.24924527
85Abnormality of incisor morphology (HP:0011063)2.23857316
86Keratoconjunctivitis sicca (HP:0001097)2.22488314
87Abnormality of T cell physiology (HP:0011840)2.22299110
88Parakeratosis (HP:0001036)2.21819201
89Hemiparesis (HP:0001269)2.21097666
90Decreased circulating renin level (HP:0003351)2.20644735
91Dysmetria (HP:0001310)2.20537964
92Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17360015
93Abnormality of the columella (HP:0009929)2.14350748
94Palmoplantar hyperkeratosis (HP:0000972)2.13352045
95Epidermoid cyst (HP:0200040)2.12146380
96Hemoptysis (HP:0002105)2.08597457
97Eosinophilia (HP:0001880)2.08528416
98Pulmonary infiltrates (HP:0002113)2.07763600
99Increased IgM level (HP:0003496)2.07512348
100Conjunctival hamartoma (HP:0100780)2.05610394
101Vasculitis (HP:0002633)2.05138568
102Palmar hyperkeratosis (HP:0010765)2.04418409
103Corneal erosion (HP:0200020)2.04117452
104Gangrene (HP:0100758)2.03361667
105Attenuation of retinal blood vessels (HP:0007843)2.02119254
106Abolished electroretinogram (ERG) (HP:0000550)2.01072769
107Recurrent bacterial skin infections (HP:0005406)2.00036978
108Hypolipoproteinemia (HP:0010981)2.00021903
109Widely spaced teeth (HP:0000687)1.99806673
110Keratoconjunctivitis (HP:0001096)1.98508537
111Leukocytosis (HP:0001974)1.98412293
112Blue irides (HP:0000635)1.97165254
113Tetraplegia (HP:0002445)1.96861193
114Mitral stenosis (HP:0001718)1.94444227
115Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91159642
116Hypergammaglobulinemia (HP:0010702)1.89265426
117Cone-rod dystrophy (HP:0000548)1.88811621
118Photophobia (HP:0000613)1.88669776
119Skin nodule (HP:0200036)1.88302387
120Anxiety (HP:0000739)1.87438067
121Impaired smooth pursuit (HP:0007772)1.87250048
122Muscle fiber inclusion bodies (HP:0100299)1.87093758
123Impaired social interactions (HP:0000735)1.86667397
124Abnormal social behavior (HP:0012433)1.86667397
125Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.85881006
126Abnormality of glutamine family amino acid metabolism (HP:0010902)1.85745093
127Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.85606198
128Recurrent gram-negative bacterial infections (HP:0005420)1.84376956
129Nemaline bodies (HP:0003798)1.82784395
130Hematochezia (HP:0002573)1.79709240
131Conjugated hyperbilirubinemia (HP:0002908)1.77262602
132Verrucae (HP:0200043)1.77222801
133Papilloma (HP:0012740)1.77222801
134Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76929751
135Abnormality of saccadic eye movements (HP:0000570)1.75156682
136Generalized myoclonic seizures (HP:0002123)1.74993090
137Neurofibrillary tangles (HP:0002185)1.74714877
138Alopecia of scalp (HP:0002293)1.74489513
139Areflexia of lower limbs (HP:0002522)1.73746895
140Encephalitis (HP:0002383)1.72952446
141Agitation (HP:0000713)1.72084964
142Aplasia involving bones of the upper limbs (HP:0009823)1.71941234
143Aplasia of the phalanges of the hand (HP:0009802)1.71941234
144Aplasia involving bones of the extremities (HP:0009825)1.71941234
145Depression (HP:0000716)1.71474751
146Fair hair (HP:0002286)1.71473830
147Severe Myopia (HP:0011003)1.71456206
148Drooling (HP:0002307)1.71266273
149Excessive salivation (HP:0003781)1.71266273
150EEG with generalized epileptiform discharges (HP:0011198)1.70369113
151Pulmonary embolism (HP:0002204)1.69915019
152Neoplasm of the tracheobronchial system (HP:0100552)1.69611948
153Conical tooth (HP:0000698)1.69452181
154Hypobetalipoproteinemia (HP:0003563)1.69072754
155Synostosis involving the elbow (HP:0003938)1.69021795
156Humeroradial synostosis (HP:0003041)1.69021795
157Myokymia (HP:0002411)1.68649744
158Epileptiform EEG discharges (HP:0011182)1.68599904
159Thick nail (HP:0001805)1.68017005
160Anhidrosis (HP:0000970)1.67743292
161Autoimmune thrombocytopenia (HP:0001973)1.66424658
162Poor eye contact (HP:0000817)1.66357649
163Abnormality of ocular smooth pursuit (HP:0000617)1.65356928
164Gingival bleeding (HP:0000225)1.65203212
165Atrioventricular block (HP:0001678)1.64946963
166Increased corneal curvature (HP:0100692)1.62231477
167Keratoconus (HP:0000563)1.62231477
168Decreased electroretinogram (ERG) amplitude (HP:0000654)1.61769437
169Vitreoretinal degeneration (HP:0000655)1.60160950
170Abnormality of vision evoked potentials (HP:0000649)1.59838570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK32.91301057
2TXK2.87475709
3INSRR2.32716771
4MAP4K12.23508998
5MAP2K42.21647824
6NLK2.14610480
7STK242.13227010
8MAP3K42.01524119
9SIK11.87983845
10AKT31.75939148
11CASK1.67439836
12NTRK31.64024682
13MAP3K71.61833977
14CAMKK21.60591154
15MAP2K71.57210592
16JAK11.55276154
17MAPK151.55218095
18RIPK11.50621163
19GRK61.48487386
20IRAK31.46221007
21NTRK21.44588224
22MAP3K91.44151822
23CAMK1G1.42011276
24TYK21.41207369
25SGK21.40366931
26STK381.39020042
27EPHA41.37697245
28TRPM71.34809119
29EPHA31.32800125
30CSK1.30455663
31DAPK21.30066620
32FER1.29747782
33TEC1.25269369
34FRK1.23621380
35FGFR31.23503270
36SGK31.21621028
37PNCK1.17651810
38SGK2231.16170407
39SGK4941.16170407
40GRK11.15871508
41MAP3K21.15512827
42TNIK1.14450132
43LCK1.14179833
44FGFR41.12203241
45PINK11.11833675
46ITK1.08436826
47BTK1.07679327
48SYK1.07125404
49MINK11.05962348
50PAK61.03393581
51FGFR21.02955703
52ZAP701.02276392
53PHKG21.02262294
54PHKG11.02262294
55MAPK121.02191333
56CAMKK11.02142332
57CDK31.01622561
58MARK31.01093506
59TNK21.00959214
60STK110.96742199
61HIPK20.96141110
62SIK20.94415170
63IKBKB0.93920333
64WNK10.93891200
65MAP3K120.93566932
66PRKCH0.92670494
67BRD40.90292935
68RIPK40.90287237
69GRK50.88833478
70MAPKAPK50.88775644
71MAP3K140.87276319
72NTRK10.86806078
73MAP3K130.86349860
74MAPK70.85885965
75MAP3K60.85169837
76BLK0.84801919
77JAK30.84403062
78RET0.83436878
79HCK0.80629921
80PASK0.80146316
81PIM10.78957620
82JAK20.78280081
83TGFBR20.77329698
84PIK3CG0.76563059
85PTK60.76121986
86CAMK2G0.76098240
87CDK50.73783794
88CAMK2A0.73627672
89LATS10.73440975
90MST1R0.73414051
91MELK0.72813732
92CAMK10.71040293
93PDK10.69250717
94SIK30.68709852
95NEK60.68277059
96CAMK2D0.67974305
97MAP2K60.67961676
98FES0.67823694
99SGK10.67002694
100CAMK1D0.66956586
101PRKCG0.66641532
102PRKCE0.66597917
103ERBB40.65723882
104PRKAA20.64684770
105MUSK0.63633550
106MAP3K10.62798723
107PAK30.60969591
108DYRK1A0.60854319
109BMPR20.60604398
110PKN10.59755609
111GRK70.57504793
112LYN0.55734217
113PRKG10.55634684
114MAPKAPK30.55386419
115PDGFRB0.55384777
116PRKCZ0.54892691
117IRAK10.54209431
118RPS6KB10.54113540
119PIK3CA0.53923009
120EPHB10.53690909
121PDPK10.53682058
122TGFBR10.53411690
123DMPK0.52829528
124CAMK40.52780713
125PRKAA10.51478031
126OBSCN0.51434181
127STK100.50276512
128MARK20.49665142
129PRPF4B0.49653834
130ADRBK20.49598522
131KIT0.48714937
132RPS6KA30.48423590
133PRKCQ0.48189333
134FGFR10.47915846
135IKBKE0.47835022
136MAPK110.47553994
137TYRO30.47242806
138MOS0.45187902
139KSR20.44804840
140FYN0.44397334
141MAP3K30.43477796
142FGR0.42451290
143CHUK0.40555081

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.05096632
2Phototransduction_Homo sapiens_hsa047442.79980852
3T cell receptor signaling pathway_Homo sapiens_hsa046602.76088406
4Primary immunodeficiency_Homo sapiens_hsa053402.65264272
5Nicotine addiction_Homo sapiens_hsa050332.53164374
6GABAergic synapse_Homo sapiens_hsa047272.13480564
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09099753
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.99685135
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97780034
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92654601
11Arginine biosynthesis_Homo sapiens_hsa002201.85836785
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84248397
13Synaptic vesicle cycle_Homo sapiens_hsa047211.68896111
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68810227
15Glutamatergic synapse_Homo sapiens_hsa047241.62106028
16Allograft rejection_Homo sapiens_hsa053301.55429501
17Autoimmune thyroid disease_Homo sapiens_hsa053201.54735922
18Circadian entrainment_Homo sapiens_hsa047131.54017635
19* Circadian rhythm_Homo sapiens_hsa047101.53504456
20Morphine addiction_Homo sapiens_hsa050321.53009224
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.51407521
22Graft-versus-host disease_Homo sapiens_hsa053321.39441175
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38354863
24Butanoate metabolism_Homo sapiens_hsa006501.37576101
25Salivary secretion_Homo sapiens_hsa049701.35548185
26Long-term potentiation_Homo sapiens_hsa047201.32600277
27Insulin secretion_Homo sapiens_hsa049111.32562173
28Measles_Homo sapiens_hsa051621.30617929
29Linoleic acid metabolism_Homo sapiens_hsa005911.28331889
30Taste transduction_Homo sapiens_hsa047421.27178811
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27134419
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25935237
33Osteoclast differentiation_Homo sapiens_hsa043801.25472244
34Bile secretion_Homo sapiens_hsa049761.25448280
35Renin secretion_Homo sapiens_hsa049241.24466846
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.23508502
37FoxO signaling pathway_Homo sapiens_hsa040681.21103379
38B cell receptor signaling pathway_Homo sapiens_hsa046621.20031075
39Olfactory transduction_Homo sapiens_hsa047401.19670694
40Long-term depression_Homo sapiens_hsa047301.19098442
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15811303
42Amphetamine addiction_Homo sapiens_hsa050311.11116430
43Complement and coagulation cascades_Homo sapiens_hsa046101.10864134
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10671493
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08446289
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.08208532
47Chemokine signaling pathway_Homo sapiens_hsa040621.05656457
48Choline metabolism in cancer_Homo sapiens_hsa052311.05261859
49Retinol metabolism_Homo sapiens_hsa008301.03289610
50Gastric acid secretion_Homo sapiens_hsa049711.02308548
51Hematopoietic cell lineage_Homo sapiens_hsa046401.01038773
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00465004
53Regulation of autophagy_Homo sapiens_hsa041401.00249504
54Fatty acid degradation_Homo sapiens_hsa000711.00069057
55Platelet activation_Homo sapiens_hsa046110.99967407
56PPAR signaling pathway_Homo sapiens_hsa033200.99536003
57Dopaminergic synapse_Homo sapiens_hsa047280.99519109
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98225901
59Type II diabetes mellitus_Homo sapiens_hsa049300.98080571
60ABC transporters_Homo sapiens_hsa020100.97855871
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96473167
62Fatty acid biosynthesis_Homo sapiens_hsa000610.96063736
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94707494
64VEGF signaling pathway_Homo sapiens_hsa043700.94074084
65Cholinergic synapse_Homo sapiens_hsa047250.93992247
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92709592
67Calcium signaling pathway_Homo sapiens_hsa040200.92077527
68Oxytocin signaling pathway_Homo sapiens_hsa049210.90982625
69Type I diabetes mellitus_Homo sapiens_hsa049400.90215798
70Non-small cell lung cancer_Homo sapiens_hsa052230.89971508
71TNF signaling pathway_Homo sapiens_hsa046680.89679879
72Serotonergic synapse_Homo sapiens_hsa047260.88702046
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86072414
74mTOR signaling pathway_Homo sapiens_hsa041500.85865306
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85397555
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84578060
77* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84551292
78Cocaine addiction_Homo sapiens_hsa050300.83946321
79Caffeine metabolism_Homo sapiens_hsa002320.83926184
80Tryptophan metabolism_Homo sapiens_hsa003800.83278504
81Fatty acid metabolism_Homo sapiens_hsa012120.82314674
82Pancreatic secretion_Homo sapiens_hsa049720.78765491
83cAMP signaling pathway_Homo sapiens_hsa040240.78039108
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76738314
85Ras signaling pathway_Homo sapiens_hsa040140.76284562
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74640777
87GnRH signaling pathway_Homo sapiens_hsa049120.72965566
88beta-Alanine metabolism_Homo sapiens_hsa004100.72867852
89Peroxisome_Homo sapiens_hsa041460.71013706
90Phenylalanine metabolism_Homo sapiens_hsa003600.70982369
91Prolactin signaling pathway_Homo sapiens_hsa049170.70690661
92Glycerolipid metabolism_Homo sapiens_hsa005610.70659733
93Renal cell carcinoma_Homo sapiens_hsa052110.69834926
94Acute myeloid leukemia_Homo sapiens_hsa052210.69497363
95Estrogen signaling pathway_Homo sapiens_hsa049150.68645948
96Malaria_Homo sapiens_hsa051440.67953277
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.67664882
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.66689518
99Ether lipid metabolism_Homo sapiens_hsa005650.66578584
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66054242
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.65846809
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64963752
103Leishmaniasis_Homo sapiens_hsa051400.64258521
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63356403
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.62809755
106Fatty acid elongation_Homo sapiens_hsa000620.62747793
107Glucagon signaling pathway_Homo sapiens_hsa049220.62310976
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61913323
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.61791214
110Propanoate metabolism_Homo sapiens_hsa006400.61724583
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61170210
112Staphylococcus aureus infection_Homo sapiens_hsa051500.60608938
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60597474
114Inositol phosphate metabolism_Homo sapiens_hsa005620.58643273
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.58483811
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.57215875
117Insulin resistance_Homo sapiens_hsa049310.56827078
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56751678
119Dorso-ventral axis formation_Homo sapiens_hsa043200.56538879
120Tyrosine metabolism_Homo sapiens_hsa003500.56140235
121Thyroid hormone synthesis_Homo sapiens_hsa049180.55228968
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55207612
123Chemical carcinogenesis_Homo sapiens_hsa052040.55054761
124Toxoplasmosis_Homo sapiens_hsa051450.54952556
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.54822961
126Collecting duct acid secretion_Homo sapiens_hsa049660.53380911
127Histidine metabolism_Homo sapiens_hsa003400.53018018
128Dilated cardiomyopathy_Homo sapiens_hsa054140.53010587
129African trypanosomiasis_Homo sapiens_hsa051430.51806851
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51464754
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51090058
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.50256910
133Glioma_Homo sapiens_hsa052140.48846700
134Starch and sucrose metabolism_Homo sapiens_hsa005000.48252717
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48128748
136Fat digestion and absorption_Homo sapiens_hsa049750.42703262
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42215530
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41973194
139Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41926225
140Sulfur metabolism_Homo sapiens_hsa009200.41572384
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41300827
142MAPK signaling pathway_Homo sapiens_hsa040100.41005143
143Ovarian steroidogenesis_Homo sapiens_hsa049130.39284220
144Melanogenesis_Homo sapiens_hsa049160.37931781
145Gap junction_Homo sapiens_hsa045400.37764167
146ErbB signaling pathway_Homo sapiens_hsa040120.36311065
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35306754
148Rheumatoid arthritis_Homo sapiens_hsa053230.34623202

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