RORC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.90694158
2L-phenylalanine catabolic process (GO:0006559)6.90694158
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.61842261
4L-phenylalanine metabolic process (GO:0006558)6.61842261
5epoxygenase P450 pathway (GO:0019373)6.41064979
6exogenous drug catabolic process (GO:0042738)6.24786838
7aromatic amino acid family catabolic process (GO:0009074)6.07990641
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.56744879
9kynurenine metabolic process (GO:0070189)5.40891100
10tryptophan catabolic process (GO:0006569)5.39808502
11indole-containing compound catabolic process (GO:0042436)5.39808502
12indolalkylamine catabolic process (GO:0046218)5.39808502
13omega-hydroxylase P450 pathway (GO:0097267)5.27204079
14bile acid biosynthetic process (GO:0006699)5.24176289
15glyoxylate metabolic process (GO:0046487)5.22150117
16alpha-linolenic acid metabolic process (GO:0036109)5.14842878
17actin-myosin filament sliding (GO:0033275)5.14735262
18muscle filament sliding (GO:0030049)5.14735262
19tryptophan metabolic process (GO:0006568)5.11842148
20cysteine metabolic process (GO:0006534)5.09482081
21sulfur amino acid catabolic process (GO:0000098)5.05498046
22complement activation, alternative pathway (GO:0006957)4.97622349
23urea cycle (GO:0000050)4.97445846
24urea metabolic process (GO:0019627)4.97445846
25skeletal muscle contraction (GO:0003009)4.95571043
26lysine metabolic process (GO:0006553)4.89937969
27lysine catabolic process (GO:0006554)4.89937969
28ethanol metabolic process (GO:0006067)4.81098631
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.73983005
30high-density lipoprotein particle remodeling (GO:0034375)4.72921052
31homocysteine metabolic process (GO:0050667)4.72090403
32serine family amino acid catabolic process (GO:0009071)4.70120414
33protein carboxylation (GO:0018214)4.67639443
34peptidyl-glutamic acid carboxylation (GO:0017187)4.67639443
35regulation of protein activation cascade (GO:2000257)4.59645093
36nitrogen cycle metabolic process (GO:0071941)4.57218513
37bile acid metabolic process (GO:0008206)4.55354447
38negative regulation of fibrinolysis (GO:0051918)4.54553319
39regulation of triglyceride catabolic process (GO:0010896)4.52336920
40amino-acid betaine metabolic process (GO:0006577)4.50435656
41drug metabolic process (GO:0017144)4.44382198
42regulation of skeletal muscle contraction (GO:0014819)4.41639466
43aromatic amino acid family metabolic process (GO:0009072)4.39571308
44regulation of fibrinolysis (GO:0051917)4.39155112
45sarcoplasmic reticulum calcium ion transport (GO:0070296)4.38713211
46cellular ketone body metabolic process (GO:0046950)4.38677740
47alpha-amino acid catabolic process (GO:1901606)4.36148911
48acylglycerol homeostasis (GO:0055090)4.34683407
49triglyceride homeostasis (GO:0070328)4.34683407
50regulation of complement activation (GO:0030449)4.31818898
51fructose metabolic process (GO:0006000)4.27417458
52actin-mediated cell contraction (GO:0070252)4.26176128
53tyrosine metabolic process (GO:0006570)4.23943238
54valine metabolic process (GO:0006573)4.21716798
55creatine metabolic process (GO:0006600)4.17055088
56negative regulation of cholesterol transport (GO:0032375)4.15611899
57negative regulation of sterol transport (GO:0032372)4.15611899
58reverse cholesterol transport (GO:0043691)4.14541824
59oxidative demethylation (GO:0070989)4.14419938
60short-chain fatty acid metabolic process (GO:0046459)4.14144453
61plasma lipoprotein particle remodeling (GO:0034369)4.12112939
62protein-lipid complex remodeling (GO:0034368)4.12112939
63macromolecular complex remodeling (GO:0034367)4.12112939
64phospholipid efflux (GO:0033700)4.11416848
652-oxoglutarate metabolic process (GO:0006103)4.11397981
66regulation of cholesterol esterification (GO:0010872)4.11202983
67cellular modified amino acid catabolic process (GO:0042219)4.10697365
68response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.08694629
69cellular glucuronidation (GO:0052695)4.06941656
70cellular amino acid catabolic process (GO:0009063)4.05394810
71regulation of cholesterol homeostasis (GO:2000188)4.03819260
72bile acid and bile salt transport (GO:0015721)4.00297877
73skeletal muscle adaptation (GO:0043501)3.99945416
74glutamate metabolic process (GO:0006536)3.99291498
75coenzyme catabolic process (GO:0009109)3.95352089
76ethanol oxidation (GO:0006069)3.93998674
77drug catabolic process (GO:0042737)3.91549342
78plasma lipoprotein particle assembly (GO:0034377)3.83511235
79fatty acid beta-oxidation (GO:0006635)3.83265359
80indolalkylamine metabolic process (GO:0006586)3.80702467
81plasma lipoprotein particle clearance (GO:0034381)3.79775167
82ketone body metabolic process (GO:1902224)3.79427337
83glycine metabolic process (GO:0006544)3.77091307
84NADH metabolic process (GO:0006734)3.77084548
85very-low-density lipoprotein particle assembly (GO:0034379)3.74875095
86benzene-containing compound metabolic process (GO:0042537)3.74805743
87fatty acid oxidation (GO:0019395)3.73488714
88acetyl-CoA metabolic process (GO:0006084)3.73297534
89aspartate family amino acid catabolic process (GO:0009068)3.70924404
90serine family amino acid metabolic process (GO:0009069)3.70905685
91amino-acid betaine transport (GO:0015838)3.70325959
92carnitine transport (GO:0015879)3.70325959
93dicarboxylic acid biosynthetic process (GO:0043650)3.70053746
94organic acid catabolic process (GO:0016054)3.67582520
95carboxylic acid catabolic process (GO:0046395)3.67582520
96monocarboxylic acid catabolic process (GO:0072329)3.65856304
97positive regulation of fatty acid beta-oxidation (GO:0032000)3.65770976
98lipid oxidation (GO:0034440)3.65546808
99amine catabolic process (GO:0009310)3.65095845
100cellular biogenic amine catabolic process (GO:0042402)3.65095845
101regulation of bile acid biosynthetic process (GO:0070857)3.63560744
102fatty acid catabolic process (GO:0009062)3.60683886
103phospholipid homeostasis (GO:0055091)3.58827809
104pyrimidine nucleoside catabolic process (GO:0046135)3.57804586
105positive regulation of lipid catabolic process (GO:0050996)3.57257769
106cholesterol efflux (GO:0033344)3.55983225
107glucuronate metabolic process (GO:0019585)3.55785289
108uronic acid metabolic process (GO:0006063)3.55785289
109phenylpropanoid metabolic process (GO:0009698)3.55777607
110response to mercury ion (GO:0046689)3.54743086
111quaternary ammonium group transport (GO:0015697)3.53319545
112intestinal cholesterol absorption (GO:0030299)3.52137471
113drug transmembrane transport (GO:0006855)3.51847542
114imidazole-containing compound metabolic process (GO:0052803)3.50853764
115negative regulation of lipase activity (GO:0060192)3.49050539
116response to muscle activity (GO:0014850)3.48112530
117carnitine metabolic process (GO:0009437)3.47401871
118negative regulation of protein activation cascade (GO:2000258)3.45363306
119cholesterol homeostasis (GO:0042632)3.44076907
120protein-lipid complex assembly (GO:0065005)3.42676464
121arginine metabolic process (GO:0006525)3.42010441
122low-density lipoprotein particle remodeling (GO:0034374)3.41690658
123glycogen catabolic process (GO:0005980)3.41677831
124regulation of relaxation of muscle (GO:1901077)3.40083035
125glucan catabolic process (GO:0009251)3.38683415
126sterol homeostasis (GO:0055092)3.38598010
127macroautophagy (GO:0016236)3.37500984
128actin filament-based movement (GO:0030048)3.36124621
129positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.35885912
130flavonoid metabolic process (GO:0009812)3.35781618
131myofibril assembly (GO:0030239)3.34576154
132blood coagulation, intrinsic pathway (GO:0007597)3.31275473
133protein activation cascade (GO:0072376)3.27686049
134fibrinolysis (GO:0042730)3.26172009
135striated muscle contraction (GO:0006941)3.25900578
136carnitine shuttle (GO:0006853)3.24283383
137regulation of humoral immune response (GO:0002920)3.22867783
138oxaloacetate metabolic process (GO:0006107)3.21239925
139fatty acid transmembrane transport (GO:1902001)3.21204774
140negative regulation of complement activation (GO:0045916)3.16007972
141primary alcohol catabolic process (GO:0034310)3.14808098
142complement activation (GO:0006956)3.13634873
143complement activation, classical pathway (GO:0006958)3.12394332
144cellular polysaccharide catabolic process (GO:0044247)3.12257209
145carnitine transmembrane transport (GO:1902603)3.09299441
146positive regulation of lipoprotein lipase activity (GO:0051006)3.08966142
147positive regulation of triglyceride lipase activity (GO:0061365)3.08966142
148negative regulation of humoral immune response (GO:0002921)3.08907974
149striated muscle atrophy (GO:0014891)3.02033661
150acute-phase response (GO:0006953)3.00242327
151alkaloid metabolic process (GO:0009820)2.96989209
152sarcomere organization (GO:0045214)2.85128385
153polysaccharide catabolic process (GO:0000272)2.83715332
154regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.78738318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.54181902
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.58313487
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.97586468
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.55566708
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.43738111
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.82538151
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.33876703
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.74610676
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.17489074
10* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.59768781
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.18763659
12* CLOCK_20551151_ChIP-Seq_293T_Human2.00967384
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4691491
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90837594
15BP1_19119308_ChIP-ChIP_Hs578T_Human1.85069072
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84731281
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72777606
18FOXA2_19822575_ChIP-Seq_HepG2_Human1.58768330
19DROSHA_22980978_ChIP-Seq_HELA_Human1.53552504
20* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49266627
21GATA1_22025678_ChIP-Seq_K562_Human1.43336116
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40943477
23ZNF263_19887448_ChIP-Seq_K562_Human1.39883671
24* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34293590
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34032928
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29541666
27* HNF4A_19822575_ChIP-Seq_HepG2_Human1.29303166
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25774906
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24248835
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.22715928
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22139354
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19846159
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.12476160
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10671079
35GATA4_25053715_ChIP-Seq_YYC3_Human1.08495649
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08177089
37HTT_18923047_ChIP-ChIP_STHdh_Human1.01713962
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01238630
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98913859
40FOXO3_23340844_ChIP-Seq_DLD1_Human0.98908331
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97658683
42* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96611325
43ESR1_20079471_ChIP-ChIP_T-47D_Human0.96274421
44RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94127747
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92548544
46IRF8_22096565_ChIP-ChIP_GC-B_Human0.91637495
47SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90856049
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90271495
49GATA2_21666600_ChIP-Seq_HMVEC_Human0.90056279
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89925145
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88478664
52ER_23166858_ChIP-Seq_MCF-7_Human0.87984722
53PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87753978
54CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87132775
55TBX20_22080862_ChIP-Seq_HEART_Mouse0.86687511
56TBX20_22328084_ChIP-Seq_HEART_Mouse0.86687511
57NFE2_27457419_Chip-Seq_LIVER_Mouse0.86175254
58EP300_21415370_ChIP-Seq_HL-1_Mouse0.85620113
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85011664
60SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84224986
61CDX2_22108803_ChIP-Seq_LS180_Human0.84053767
62EZH2_27294783_Chip-Seq_NPCs_Mouse0.83670927
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83550902
64PIAS1_25552417_ChIP-Seq_VCAP_Human0.83087440
65EGR1_19032775_ChIP-ChIP_M12_Human0.82843207
66* LXR_22292898_ChIP-Seq_THP-1_Human0.82774720
67GATA6_21074721_ChIP-Seq_CACO-2_Human0.82636907
68* CTCF_27219007_Chip-Seq_Bcells_Human0.82509893
69STAT1_20625510_ChIP-Seq_HELA_Human0.81408612
70* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81282417
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.80289547
72AR_21572438_ChIP-Seq_LNCaP_Human0.80275993
73SMAD_19615063_ChIP-ChIP_OVARY_Human0.79896484
74HNFA_21074721_ChIP-Seq_CACO-2_Human0.79833874
75AHR_22903824_ChIP-Seq_MCF-7_Human0.79711263
76CDX2_20551321_ChIP-Seq_CACO-2_Human0.77490712
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.77420898
78FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77163348
79RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77099932
80GATA6_25053715_ChIP-Seq_YYC3_Human0.76860782
81STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.76747908
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76687573
83CRX_20693478_ChIP-Seq_RETINA_Mouse0.75840100
84RACK7_27058665_Chip-Seq_MCF-7_Human0.75562573
85CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75497042
86PHF8_20622853_ChIP-Seq_HELA_Human0.75456126
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.75160657
88OCT4_21477851_ChIP-Seq_ESCs_Mouse0.74310478
89GATA2_19941826_ChIP-Seq_K562_Human0.74304064
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73916636
91FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73837186
92PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73744412
93TRIM28_21343339_ChIP-Seq_HEK293_Human0.73369715
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72990097
95GATA1_19941826_ChIP-Seq_K562_Human0.72835158
96FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.72252014
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72228411
98SMC4_20622854_ChIP-Seq_HELA_Human0.71902514
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71801291
100BCAT_22108803_ChIP-Seq_LS180_Human0.71795112
101CEBPB_22108803_ChIP-Seq_LS180_Human0.71656387
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.71435252
103TCF4_18268006_ChIP-ChIP_LS174T_Human0.70503245
104FOXA1_25552417_ChIP-Seq_VCAP_Human0.70417032
105* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70245995
106TP63_17297297_ChIP-ChIP_HaCaT_Human0.70036683
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69787131
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69710060
109RUNX_20019798_ChIP-Seq_JUKART_Human0.67378950
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.67255864
111RARA_24833708_ChIP-Seq_LIVER_Mouse0.64663783
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.63852150
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62198016
114* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62099144
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61945969
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.61026165
117RARB_24833708_ChIP-Seq_LIVER_Mouse0.60717401
118Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.59611958
119AR_20517297_ChIP-Seq_VCAP_Human0.58652306
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.58407402
121ATF3_27146783_Chip-Seq_COLON_Human0.58219546
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.57735585
123P63_26484246_Chip-Seq_KERATINOCYTES_Human0.57498292
124* GATA3_24758297_ChIP-Seq_MCF-7_Human0.57493267
125SOX2_20726797_ChIP-Seq_SW620_Human0.56411192
126RUNX1_27514584_Chip-Seq_MCF-7_Human0.55812272
127* CREB1_26743006_Chip-Seq_LNCaP_Human0.55676066
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.54325024
129TCF7_22412390_ChIP-Seq_EML_Mouse0.54244907
130SALL4_18804426_ChIP-ChIP_XEN_Mouse0.53563375
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53345929
132ESR1_15608294_ChIP-ChIP_MCF-7_Human0.53333762
133LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.52997083
134E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.52683248
135KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.52602874
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52531679
137TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.51973754
138CTCF_21964334_ChIP-Seq_BJAB-B_Human0.51170234
139KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.50513751
140CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.50065443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.22169736
2MP0005360_urolithiasis6.77480022
3MP0005365_abnormal_bile_salt5.96761028
4MP0005085_abnormal_gallbladder_physiolo5.85400540
5MP0008875_abnormal_xenobiotic_pharmacok4.52665679
6MP0003252_abnormal_bile_duct4.07423678
7MP0004145_abnormal_muscle_electrophysio3.76150730
8MP0003806_abnormal_nucleotide_metabolis3.61352927
9MP0010329_abnormal_lipoprotein_level3.24855710
10MP0005083_abnormal_biliary_tract2.92244535
11MP0000751_myopathy2.80814216
12MP0001666_abnormal_nutrient_absorption2.80709451
13MP0003195_calcinosis2.72209093
14MP0009840_abnormal_foam_cell2.66963932
15MP0005332_abnormal_amino_acid2.62409713
16MP0000609_abnormal_liver_physiology2.18235993
17MP0004019_abnormal_vitamin_homeostasis2.06570914
18MP0002138_abnormal_hepatobiliary_system2.06439174
19MP0002118_abnormal_lipid_homeostasis2.05582879
20MP0002106_abnormal_muscle_physiology1.92141579
21MP0003868_abnormal_feces_composition1.90813794
22MP0003191_abnormal_cellular_cholesterol1.84759764
23MP0004084_abnormal_cardiac_muscle1.84536662
24MP0002332_abnormal_exercise_endurance1.83012365
25MP0005319_abnormal_enzyme/_coenzyme1.75515058
26MP0004233_abnormal_muscle_weight1.73841810
27MP0003879_abnormal_hair_cell1.70205649
28MP0005369_muscle_phenotype1.61220036
29MP0000759_abnormal_skeletal_muscle1.57671312
30MP0001764_abnormal_homeostasis1.55773211
31MP0004130_abnormal_muscle_cell1.55417166
32MP0009780_abnormal_chondrocyte_physiolo1.54196797
33MP0005584_abnormal_enzyme/coenzyme_acti1.51085151
34MP0009643_abnormal_urine_homeostasis1.50151114
35MP0002837_dystrophic_cardiac_calcinosis1.48063205
36MP0000013_abnormal_adipose_tissue1.45936969
37MP0005620_abnormal_muscle_contractility1.44827953
38MP0005451_abnormal_body_composition1.41341744
39MP0003705_abnormal_hypodermis_morpholog1.31016652
40MP0003300_gastrointestinal_ulcer1.29334774
41MP0004484_altered_response_of1.16045175
42MP0006036_abnormal_mitochondrial_physio1.14197777
43MP0002972_abnormal_cardiac_muscle1.14063826
44MP0003045_fibrosis1.10804770
45MP0001661_extended_life_span1.09111401
46MP0000598_abnormal_liver_morphology1.07988280
47MP0002078_abnormal_glucose_homeostasis1.06918974
48MP0005636_abnormal_mineral_homeostasis1.05992450
49MP0002822_catalepsy1.04406131
50MP0002971_abnormal_brown_adipose1.03965314
51MP0002108_abnormal_muscle_morphology1.03709051
52MP0005647_abnormal_sex_gland1.02764856
53MP0002168_other_aberrant_phenotype1.02281689
54MP0003186_abnormal_redox_activity0.99733876
55MP0005220_abnormal_exocrine_pancreas0.98761872
56MP0002254_reproductive_system_inflammat0.97268230
57MP0004510_myositis0.96585676
58MP0005670_abnormal_white_adipose0.94286210
59MP0009764_decreased_sensitivity_to0.93365195
60MP0004264_abnormal_extraembryonic_tissu0.93182205
61MP0000003_abnormal_adipose_tissue0.92965376
62MP0005666_abnormal_adipose_tissue0.92729550
63MP0010234_abnormal_vibrissa_follicle0.90915329
64MP0008872_abnormal_physiological_respon0.90745807
65MP0009697_abnormal_copulation0.90326181
66MP0005334_abnormal_fat_pad0.89433342
67MP0002166_altered_tumor_susceptibility0.88265980
68MP0005377_hearing/vestibular/ear_phenot0.88253588
69MP0003878_abnormal_ear_physiology0.88253588
70MP0000750_abnormal_muscle_regeneration0.87249092
71MP0009763_increased_sensitivity_to0.86778576
72MP0009642_abnormal_blood_homeostasis0.86763467
73MP0004947_skin_inflammation0.84093872
74* MP0008469_abnormal_protein_level0.83810641
75MP0003656_abnormal_erythrocyte_physiolo0.83028136
76MP0004215_abnormal_myocardial_fiber0.82867713
77MP0002928_abnormal_bile_duct0.82216311
78MP0005535_abnormal_body_temperature0.81147255
79MP0003646_muscle_fatigue0.80194253
80MP0006138_congestive_heart_failure0.78215592
81MP0006035_abnormal_mitochondrial_morpho0.76868724
82MP0002796_impaired_skin_barrier0.76053481
83MP0001756_abnormal_urination0.74851970
84MP0004043_abnormal_pH_regulation0.73759562
85MP0009765_abnormal_xenobiotic_induced0.72136909
86MP0002127_abnormal_cardiovascular_syste0.71792586
87MP0001544_abnormal_cardiovascular_syste0.71142912
88MP0005385_cardiovascular_system_phenoty0.71142912
89MP0003011_delayed_dark_adaptation0.71087894
90MP0005448_abnormal_energy_balance0.70084599
91MP0002876_abnormal_thyroid_physiology0.69872371
92MP0004782_abnormal_surfactant_physiolog0.68657726
93MP0000733_abnormal_muscle_development0.68194009
94MP0008961_abnormal_basal_metabolism0.67702445
95MP0005376_homeostasis/metabolism_phenot0.67641402
96MP0001501_abnormal_sleep_pattern0.66194904
97MP0010630_abnormal_cardiac_muscle0.66156294
98MP0005166_decreased_susceptibility_to0.65968702
99* MP0010155_abnormal_intestine_physiology0.65549784
100MP0001984_abnormal_olfaction0.64301028
101MP0002269_muscular_atrophy0.64287685
102MP0005330_cardiomyopathy0.63354917
103MP0002136_abnormal_kidney_physiology0.63279002
104MP0010368_abnormal_lymphatic_system0.63094775
105MP0001881_abnormal_mammary_gland0.62488845
106MP0001765_abnormal_ion_homeostasis0.61195520
107MP0005266_abnormal_metabolism0.60539826
108MP0004185_abnormal_adipocyte_glucose0.59970357
109MP0000604_amyloidosis0.58638048
110MP0000249_abnormal_blood_vessel0.58362055
111MP0003866_abnormal_defecation0.57869849
112MP0005409_darkened_coat_color0.57557597
113MP0001243_abnormal_dermal_layer0.57317520
114MP0001944_abnormal_pancreas_morphology0.56829697
115MP0003436_decreased_susceptibility_to0.56602612
116MP0003959_abnormal_lean_body0.55335759
117MP0002060_abnormal_skin_morphology0.55062232
118MP0003724_increased_susceptibility_to0.55039859
119MP0004036_abnormal_muscle_relaxation0.54697634
120MP0005408_hypopigmentation0.54690599
121MP0002132_abnormal_respiratory_system0.52946140
122MP0000685_abnormal_immune_system0.52637991
123MP0005375_adipose_tissue_phenotype0.52408671
124MP0003638_abnormal_response/metabolism_0.52008550
125MP0005084_abnormal_gallbladder_morpholo0.51427168
126MP0003953_abnormal_hormone_level0.51219605
127MP0000230_abnormal_systemic_arterial0.50813353
128MP0001849_ear_inflammation0.49300619
129MP0000747_muscle_weakness0.47375846
130* MP0001845_abnormal_inflammatory_respons0.46813314
131MP0000749_muscle_degeneration0.46405207
132MP0004087_abnormal_muscle_fiber0.45775655
133MP0002970_abnormal_white_adipose0.45496871
134MP0001853_heart_inflammation0.45435768
135MP0002933_joint_inflammation0.45021226
136MP0003453_abnormal_keratinocyte_physiol0.43425167
137MP0005464_abnormal_platelet_physiology0.43093907
138MP0009115_abnormal_fat_cell0.42308621
139MP0004381_abnormal_hair_follicle0.41962719

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.65061199
2Nemaline bodies (HP:0003798)7.51897159
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.25436867
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.37142834
5Intrahepatic cholestasis (HP:0001406)6.09061891
6Deep venous thrombosis (HP:0002625)6.02168886
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.64184901
8Xanthomatosis (HP:0000991)5.54568996
9Hypobetalipoproteinemia (HP:0003563)5.41551896
10Type 1 muscle fiber predominance (HP:0003803)5.33104776
11Prolonged partial thromboplastin time (HP:0003645)5.09305029
12Exercise-induced muscle cramps (HP:0003710)4.98895541
13Muscle hypertrophy of the lower extremities (HP:0008968)4.59609601
14Hypoglycemic coma (HP:0001325)4.58767999
15Ketosis (HP:0001946)4.56062977
16Hyperlipoproteinemia (HP:0010980)4.53765517
17Hyperammonemia (HP:0001987)4.41621466
18Hyperglycinuria (HP:0003108)4.41528146
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.35596408
20Hypolipoproteinemia (HP:0010981)4.22991349
21Complement deficiency (HP:0004431)4.20890121
22Calf muscle hypertrophy (HP:0008981)4.13345933
23Abnormality of serine family amino acid metabolism (HP:0010894)4.12917005
24Abnormality of glycine metabolism (HP:0010895)4.12917005
25Myopathic facies (HP:0002058)4.10566474
26Hyperglycinemia (HP:0002154)3.97731103
27Epidermoid cyst (HP:0200040)3.90507594
28Ketoacidosis (HP:0001993)3.88576007
29Abnormality of the common coagulation pathway (HP:0010990)3.84693749
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.83266018
31Hypoalphalipoproteinemia (HP:0003233)3.82823685
32Joint hemorrhage (HP:0005261)3.82728093
33EMG: myopathic abnormalities (HP:0003458)3.82017336
34Distal arthrogryposis (HP:0005684)3.81824981
35Abnormality of sulfur amino acid metabolism (HP:0004339)3.79016269
36Fat malabsorption (HP:0002630)3.67967994
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.66671778
38Hyporeflexia of lower limbs (HP:0002600)3.56378440
39Abnormality of fatty-acid metabolism (HP:0004359)3.53730418
40Abnormality of methionine metabolism (HP:0010901)3.50324780
41Muscle fiber splitting (HP:0003555)3.45259623
42Abnormality of the intrinsic pathway (HP:0010989)3.33635308
43Round ear (HP:0100830)3.33342222
44Abnormality of the calf musculature (HP:0001430)3.26003180
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.24386899
46Ulnar deviation of the wrist (HP:0003049)3.18544668
47Centrally nucleated skeletal muscle fibers (HP:0003687)3.18262011
48Gout (HP:0001997)3.16745967
49Conjugated hyperbilirubinemia (HP:0002908)3.12058234
50Dicarboxylic aciduria (HP:0003215)3.10751891
51Abnormality of dicarboxylic acid metabolism (HP:0010995)3.10751891
52Glomerulonephritis (HP:0000099)3.10274535
53Hyperkalemia (HP:0002153)3.07333982
54Hypercholesterolemia (HP:0003124)3.06788420
55Asymmetric septal hypertrophy (HP:0001670)3.04753186
56Abnormality of purine metabolism (HP:0004352)3.03575884
57Neck muscle weakness (HP:0000467)3.00566761
58Hypoplasia of the thymus (HP:0000778)2.98654750
59Abnormality of nucleobase metabolism (HP:0010932)2.98159753
60Abnormality of complement system (HP:0005339)2.95959182
61Hypoglycemic seizures (HP:0002173)2.91416916
62Hyperbilirubinemia (HP:0002904)2.90961215
63Metabolic acidosis (HP:0001942)2.90211266
64Abnormality of pyrimidine metabolism (HP:0004353)2.87327493
65Distal lower limb muscle weakness (HP:0009053)2.86556885
66Myoglobinuria (HP:0002913)2.79799937
67Hyperinsulinemic hypoglycemia (HP:0000825)2.76554393
68Abnormality of skeletal muscle fiber size (HP:0012084)2.75120488
69Rimmed vacuoles (HP:0003805)2.74462579
70Hydroxyprolinuria (HP:0003080)2.73120636
71Abnormality of proline metabolism (HP:0010907)2.73120636
72Myocardial infarction (HP:0001658)2.70236515
73Difficulty running (HP:0009046)2.69034079
74Abnormality of serum amino acid levels (HP:0003112)2.68821209
75Late onset (HP:0003584)2.66775234
76Steatorrhea (HP:0002570)2.66121603
77Sudden death (HP:0001699)2.64149424
78Generalized aminoaciduria (HP:0002909)2.61907631
79Bundle branch block (HP:0011710)2.61274213
80Abnormality of the left ventricular outflow tract (HP:0011103)2.59080099
81Subaortic stenosis (HP:0001682)2.59080099
82Skin nodule (HP:0200036)2.56611416
83Delayed CNS myelination (HP:0002188)2.51241438
84Lethargy (HP:0001254)2.48978601
85Hepatocellular carcinoma (HP:0001402)2.47852757
86Hyperglycemia (HP:0003074)2.45815816
87Frequent falls (HP:0002359)2.42154024
88Neonatal onset (HP:0003623)2.38003875
89Muscle stiffness (HP:0003552)2.37984241
90Pancreatitis (HP:0001733)2.37683224
91Malignant hyperthermia (HP:0002047)2.37418347
92Abnormal gallbladder morphology (HP:0012437)2.36120508
93Increased connective tissue (HP:0009025)2.34405717
94Vascular calcification (HP:0004934)2.32825998
95Hyperuricemia (HP:0002149)2.32409950
96Increased purine levels (HP:0004368)2.32409950
97Exercise-induced myalgia (HP:0003738)2.30403800
98Cholelithiasis (HP:0001081)2.28434803
99Cerebral edema (HP:0002181)2.26984865
100T lymphocytopenia (HP:0005403)2.23369644
101Mildly elevated creatine phosphokinase (HP:0008180)2.23282296
102Increased variability in muscle fiber diameter (HP:0003557)2.22094672
103Spontaneous abortion (HP:0005268)2.21474837
104Absent phalangeal crease (HP:0006109)2.20685182
105Esophageal varix (HP:0002040)2.19364352
106Nephritis (HP:0000123)2.17959941
107Symptomatic seizures (HP:0011145)2.17855138
108EMG: neuropathic changes (HP:0003445)2.14059330
109Malnutrition (HP:0004395)2.13450463
110Bulbar palsy (HP:0001283)2.12457458
111Hyperactive renin-angiotensin system (HP:0000841)2.12154788
112Abnormality of T cell number (HP:0011839)2.11355162
113Rhabdomyolysis (HP:0003201)2.10303111
114Decreased circulating renin level (HP:0003351)2.08686565
115Vomiting (HP:0002013)2.08364980
116Acanthocytosis (HP:0001927)2.07393194
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.06938482
118Areflexia of lower limbs (HP:0002522)2.05489849
119Heart block (HP:0012722)2.04120703
120Renal cortical cysts (HP:0000803)2.03735818
121Cardiovascular calcification (HP:0011915)2.02715024
122Abnormality of potassium homeostasis (HP:0011042)2.02152389
123Hypochromic microcytic anemia (HP:0004840)2.00831065
124Irritability (HP:0000737)2.00410318
125Alkalosis (HP:0001948)2.00276954
126Proximal tubulopathy (HP:0000114)1.99670767
127Rhinitis (HP:0012384)1.99400855
128Absent/shortened dynein arms (HP:0200106)1.98429912
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.98429912
130Abnormal respiratory epithelium morphology (HP:0012253)1.97203412
131Abnormal respiratory motile cilium morphology (HP:0005938)1.97203412
132Spastic diplegia (HP:0001264)1.96677030
133Severe combined immunodeficiency (HP:0004430)1.92123531
134Recurrent gram-negative bacterial infections (HP:0005420)1.90838073
135Hypokalemia (HP:0002900)1.90505488
136Generalized muscle weakness (HP:0003324)1.89874734
137Systemic lupus erythematosus (HP:0002725)1.89528499
138Abnormal cartilage morphology (HP:0002763)1.87804884
139Abnormal atrioventricular conduction (HP:0005150)1.87472019
140Menorrhagia (HP:0000132)1.87318169
141Mitral stenosis (HP:0001718)1.87124816
142Thrombophlebitis (HP:0004418)1.85152290
143Abnormal ciliary motility (HP:0012262)1.84598312
144Abnormality of the gallbladder (HP:0005264)1.83301363
145Dilated cardiomyopathy (HP:0001644)1.83150768
146Acute hepatic failure (HP:0006554)1.83081263
147Popliteal pterygium (HP:0009756)1.82480525
148Enlarged kidneys (HP:0000105)1.82250966
149Right ventricular cardiomyopathy (HP:0011663)1.80984725
150B lymphocytopenia (HP:0010976)1.80100879
151Abnormality of B cell number (HP:0010975)1.80100879
152Proximal amyotrophy (HP:0007126)1.80062331
153Ventricular tachycardia (HP:0004756)1.79546233
154Gingival bleeding (HP:0000225)1.79522421
155Abnormal respiratory motile cilium physiology (HP:0012261)1.78721857
156Cholecystitis (HP:0001082)1.78147762
157Abnormal gallbladder physiology (HP:0012438)1.78147762
158Abnormality of urine glucose concentration (HP:0011016)1.77834003
159Glycosuria (HP:0003076)1.77834003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.97641547
2SIK13.56083054
3FGFR43.24004697
4ERN13.20538647
5TAOK33.13120639
6MAP3K73.09183452
7TRIB33.05285238
8PKN22.95706535
9INSRR2.80044788
10MUSK2.51341247
11PIK3CA2.15712051
12TXK1.89138118
13NUAK11.87171038
14PTK61.77647495
15OBSCN1.77048047
16PIK3CG1.71170773
17STK38L1.66830168
18TRPM71.63891246
19NLK1.52641914
20TTN1.51089424
21MAPK151.50882105
22MAP2K31.44157582
23DMPK1.41251707
24FLT31.40165004
25MST1R1.40002649
26MAPK111.31869036
27FRK1.30824554
28TYK21.30444503
29EPHA21.28661119
30EPHB11.19880961
31MAP2K41.18373840
32ZAP701.15440481
33IRAK31.14808437
34MAP4K11.14250521
35JAK11.11888314
36ERBB41.09651182
37JAK21.07216125
38NEK91.05805751
39LATS11.02812640
40TEC1.02641822
41PHKG11.02038179
42PHKG21.02038179
43GRK61.00318415
44PRKAA21.00252832
45EPHA30.98818454
46ITK0.98344328
47FGFR30.96828243
48TBK10.95217183
49PINK10.94927509
50MAPK120.92483253
51MAP3K30.91533281
52MAP2K20.88842861
53PDK30.88826045
54PDK40.88826045
55MAP3K100.88656740
56CSK0.84394405
57TNK20.80618635
58RIPK10.78732968
59PDGFRB0.78462077
60DYRK1B0.77024344
61MAP2K60.76830258
62FER0.76417200
63CDK60.75299327
64PRKCQ0.73787669
65MAPK40.72105542
66MAPK70.70992987
67MAP3K140.70116579
68PRKAA10.69302280
69ACVR1B0.69149223
70KDR0.68933704
71SGK30.68777714
72AKT30.67894486
73FGFR20.67004085
74MST40.64992491
75IKBKE0.62067059
76MAP3K10.61386130
77ERBB20.61216366
78RET0.60906591
79CAMK1D0.60121068
80PDPK10.59814654
81CDC42BPA0.59403004
82EEF2K0.58782110
83MAPKAPK30.56650492
84STK380.54372270
85TAOK10.53902446
86PDK10.53689764
87GSK3A0.53533020
88TIE10.52067501
89MARK20.51544826
90CDK40.51343282
91MAP3K20.50671180
92LRRK20.50261602
93DAPK20.49951295
94CAMK40.49051407
95STK390.48199548
96WNK40.47793752
97MTOR0.44795812
98PRKG10.44698963
99MAP3K130.43492643
100ICK0.43193421
101PRKACG0.43105497
102TGFBR20.43023295
103PRKD10.42945147
104NEK60.41832187
105JAK30.40545868
106ERBB30.40139941
107PRKACA0.39402670
108MYLK0.39364694
109LMTK20.38915965
110PRKCH0.37409822
111SYK0.36224164
112MAP2K10.35423672
113CAMK2G0.35159578
114MAP3K110.35119931
115RPS6KA20.34949836
116SGK2230.34704604
117SGK4940.34704604
118SGK20.34549212
119PDK20.34424140
120BTK0.34106069
121CAMK1G0.33924228
122NME10.33693044
123MAP3K60.33649957
124BLK0.32576398
125RPS6KB10.31747031
126SGK10.30808976
127AKT20.30649455
128PRKD30.30501739
129TESK20.29922904
130OXSR10.29323181
131CAMK2D0.28123833
132HCK0.27637612
133MAPK30.26392592
134IKBKB0.25574746

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.03815039
2Nitrogen metabolism_Homo sapiens_hsa009103.31307961
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26952742
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.22968210
5Fatty acid degradation_Homo sapiens_hsa000712.85182678
6Arginine biosynthesis_Homo sapiens_hsa002202.84146686
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72969961
8Tryptophan metabolism_Homo sapiens_hsa003802.68730179
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55448124
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.41337578
11Propanoate metabolism_Homo sapiens_hsa006402.34718737
12Butanoate metabolism_Homo sapiens_hsa006502.33221582
13Complement and coagulation cascades_Homo sapiens_hsa046102.30651858
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25489464
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15313726
16Fatty acid metabolism_Homo sapiens_hsa012122.00475658
17Peroxisome_Homo sapiens_hsa041462.00157737
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96239686
19PPAR signaling pathway_Homo sapiens_hsa033201.91814163
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82372232
21Chemical carcinogenesis_Homo sapiens_hsa052041.73522371
22Histidine metabolism_Homo sapiens_hsa003401.73060308
23Caffeine metabolism_Homo sapiens_hsa002321.72901536
24beta-Alanine metabolism_Homo sapiens_hsa004101.69973782
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68553961
26Pyruvate metabolism_Homo sapiens_hsa006201.68055745
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.65975684
28Sulfur metabolism_Homo sapiens_hsa009201.59542310
29Retinol metabolism_Homo sapiens_hsa008301.59203182
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56402191
31Selenocompound metabolism_Homo sapiens_hsa004501.56355241
32Starch and sucrose metabolism_Homo sapiens_hsa005001.54427106
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53753275
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.51923890
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.51545370
36Staphylococcus aureus infection_Homo sapiens_hsa051501.50393877
37Fat digestion and absorption_Homo sapiens_hsa049751.47805874
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47081542
39Phenylalanine metabolism_Homo sapiens_hsa003601.45358496
40Bile secretion_Homo sapiens_hsa049761.44618470
41Tyrosine metabolism_Homo sapiens_hsa003501.44482155
42Carbon metabolism_Homo sapiens_hsa012001.39589522
43Fatty acid elongation_Homo sapiens_hsa000621.34338736
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24903671
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21541512
46Biosynthesis of amino acids_Homo sapiens_hsa012301.17432242
47ABC transporters_Homo sapiens_hsa020101.16273802
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.12455024
49Arginine and proline metabolism_Homo sapiens_hsa003301.06466527
50Folate biosynthesis_Homo sapiens_hsa007901.05951626
51Lysine degradation_Homo sapiens_hsa003101.05120738
52Arachidonic acid metabolism_Homo sapiens_hsa005900.99379452
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92680009
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.92515696
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91009549
56Glycerolipid metabolism_Homo sapiens_hsa005610.90066385
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89329373
58Sulfur relay system_Homo sapiens_hsa041220.85584497
59Vitamin digestion and absorption_Homo sapiens_hsa049770.81485533
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81419424
61Steroid biosynthesis_Homo sapiens_hsa001000.76279786
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75062960
63Dilated cardiomyopathy_Homo sapiens_hsa054140.72719638
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72582975
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66186685
66Insulin resistance_Homo sapiens_hsa049310.60355762
67Glutathione metabolism_Homo sapiens_hsa004800.56894784
68Fatty acid biosynthesis_Homo sapiens_hsa000610.53610905
69Pentose phosphate pathway_Homo sapiens_hsa000300.53413551
70Galactose metabolism_Homo sapiens_hsa000520.52988011
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46890540
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.44485540
73Mineral absorption_Homo sapiens_hsa049780.42668569
74Metabolic pathways_Homo sapiens_hsa011000.41772501
75Renin-angiotensin system_Homo sapiens_hsa046140.39684914
76Fructose and mannose metabolism_Homo sapiens_hsa000510.39349162
77Primary immunodeficiency_Homo sapiens_hsa053400.38364383
78Vitamin B6 metabolism_Homo sapiens_hsa007500.35994002
79One carbon pool by folate_Homo sapiens_hsa006700.35892020
80Glucagon signaling pathway_Homo sapiens_hsa049220.35578443
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34313519
82Cardiac muscle contraction_Homo sapiens_hsa042600.33331846
83Pertussis_Homo sapiens_hsa051330.32667978
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.32027358
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30595014
86Renin secretion_Homo sapiens_hsa049240.28344922
87Linoleic acid metabolism_Homo sapiens_hsa005910.25788458
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25295057
89AMPK signaling pathway_Homo sapiens_hsa041520.23867050
90Sphingolipid metabolism_Homo sapiens_hsa006000.23822522
91Insulin signaling pathway_Homo sapiens_hsa049100.19015278
92Insulin secretion_Homo sapiens_hsa049110.17765678
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16806487
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.16400753
95Calcium signaling pathway_Homo sapiens_hsa040200.16064798
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15365853
97Oxytocin signaling pathway_Homo sapiens_hsa049210.14432232
98Prion diseases_Homo sapiens_hsa050200.12413196
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.11239989
100Regulation of autophagy_Homo sapiens_hsa041400.10680483
101Gastric acid secretion_Homo sapiens_hsa049710.08819203
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.07543220
103Other glycan degradation_Homo sapiens_hsa005110.07260387
104* Circadian rhythm_Homo sapiens_hsa047100.03192347
105T cell receptor signaling pathway_Homo sapiens_hsa046600.00608520
106Prolactin signaling pathway_Homo sapiens_hsa04917-0.1506162
107Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1476747
108Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1405122
109Pancreatic secretion_Homo sapiens_hsa04972-0.1359467
110FoxO signaling pathway_Homo sapiens_hsa04068-0.1357517
111Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1310491
112* Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321-0.1092473
113Acute myeloid leukemia_Homo sapiens_hsa05221-0.1034237
114Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0818172
115Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0638104
116Type II diabetes mellitus_Homo sapiens_hsa04930-0.0537617
117Protein digestion and absorption_Homo sapiens_hsa04974-0.0452645
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0418397
119Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0249457
120Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0013395
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0001113

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