ROS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1seminiferous tubule development (GO:0072520)9.87645884
2surfactant homeostasis (GO:0043129)9.67973053
3chemical homeostasis within a tissue (GO:0048875)7.58343709
4sperm capacitation (GO:0048240)6.26705603
5production of molecular mediator involved in inflammatory response (GO:0002532)5.62132000
6regulation of T cell tolerance induction (GO:0002664)5.59837805
7negative regulation of complement activation (GO:0045916)5.29092172
8peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.26813698
9cellular anion homeostasis (GO:0030002)5.25178397
10collecting duct development (GO:0072044)4.94742414
11positive regulation of p38MAPK cascade (GO:1900745)4.89253656
12negative regulation of immunoglobulin mediated immune response (GO:0002890)4.86316072
13negative regulation of B cell mediated immunity (GO:0002713)4.86316072
14negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.83794791
15negative regulation of T-helper cell differentiation (GO:0045623)4.83794791
16cell-substrate junction assembly (GO:0007044)4.79244917
17facial nerve structural organization (GO:0021612)4.76455343
18cell adhesion mediated by integrin (GO:0033627)4.74568314
19negative regulation of protein activation cascade (GO:2000258)4.69077278
20cellular response to nitric oxide (GO:0071732)4.65630475
21phosphate ion homeostasis (GO:0055062)4.57487444
22trivalent inorganic anion homeostasis (GO:0072506)4.57487444
23positive regulation of tolerance induction (GO:0002645)4.49177761
24phospholipid scrambling (GO:0017121)4.17900612
25negative regulation of humoral immune response (GO:0002921)4.15894625
26sulfate transmembrane transport (GO:1902358)4.09394043
27regulation of hippo signaling (GO:0035330)4.07071658
28negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.05680109
29regulation of glycogen (starch) synthase activity (GO:2000465)4.01922678
30cranial nerve structural organization (GO:0021604)4.00676208
31regulation of tolerance induction (GO:0002643)3.96549827
32lung epithelium development (GO:0060428)3.92546181
33regulation of germinal center formation (GO:0002634)3.90633253
34nephron epithelium morphogenesis (GO:0072088)3.87343796
35nephron tubule morphogenesis (GO:0072078)3.87343796
36hyperosmotic salinity response (GO:0042538)3.86004159
37negative regulation of hormone biosynthetic process (GO:0032353)3.85261371
38negative regulation of hormone metabolic process (GO:0032351)3.85261371
39regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.81561714
40positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.80550249
41positive regulation of cellular amide metabolic process (GO:0034250)3.78968042
42single fertilization (GO:0007338)3.78945046
43regulation of chronic inflammatory response (GO:0002676)3.77100259
44negative regulation of Rho protein signal transduction (GO:0035024)3.75107654
45negative regulation of keratinocyte proliferation (GO:0010839)3.70956541
46renal filtration (GO:0097205)3.69341032
47kynurenine metabolic process (GO:0070189)3.68546882
48positive regulation of type 2 immune response (GO:0002830)3.66471148
49neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.65982425
50protein targeting to Golgi (GO:0000042)3.60735381
51regulation of memory T cell differentiation (GO:0043380)3.60268041
52dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.56324773
53cellular response to reactive nitrogen species (GO:1902170)3.54261131
54regulation of T-helper 2 cell differentiation (GO:0045628)3.53978323
55phosphate ion transport (GO:0006817)3.53701376
56keratinocyte proliferation (GO:0043616)3.51982760
57membrane raft organization (GO:0031579)3.51977250
58response to vitamin A (GO:0033189)3.51558461
59metanephric nephron tubule development (GO:0072234)3.50579596
60metanephric tubule development (GO:0072170)3.50579596
61anatomical structure arrangement (GO:0048532)3.48395390
62retrograde transport, vesicle recycling within Golgi (GO:0000301)3.45580507
63one-carbon compound transport (GO:0019755)3.40627022
64regulation of p38MAPK cascade (GO:1900744)3.39028549
65endocrine hormone secretion (GO:0060986)3.36742059
66negative regulation of alpha-beta T cell differentiation (GO:0046639)3.33739732
67heterotypic cell-cell adhesion (GO:0034113)3.33635790
68germinal center formation (GO:0002467)3.32953723
69mesodermal cell differentiation (GO:0048333)3.29344394
70negative regulation of B cell apoptotic process (GO:0002903)3.26236057
71pyrimidine-containing compound transmembrane transport (GO:0072531)3.26091542
72regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.23984478
73sodium ion homeostasis (GO:0055078)3.22587694
74metanephric nephron epithelium development (GO:0072243)3.22009044
75regulation of integrin-mediated signaling pathway (GO:2001044)3.20493267
76regulation of type 2 immune response (GO:0002828)3.20128985
77sulfate transport (GO:0008272)3.19667525
78response to nitric oxide (GO:0071731)3.19562508
79regulation of complement activation (GO:0030449)3.17870386
80hemidesmosome assembly (GO:0031581)3.17409798
81negative regulation of fatty acid transport (GO:2000192)3.13821322
82regulation of transforming growth factor beta2 production (GO:0032909)3.12583449
83glomerular filtration (GO:0003094)3.10283293
84transepithelial transport (GO:0070633)3.07872451
85negative regulation of type 2 immune response (GO:0002829)3.07807275
86establishment of protein localization to Golgi (GO:0072600)3.05524916
87multicellular organismal water homeostasis (GO:0050891)3.05060350
88phosphate ion transmembrane transport (GO:0035435)3.04342444
89lymphangiogenesis (GO:0001946)3.03657492
90sphingosine metabolic process (GO:0006670)3.01961411
91renal tubule morphogenesis (GO:0061333)3.01677237
92tryptophan catabolic process (GO:0006569)3.00467559
93indole-containing compound catabolic process (GO:0042436)3.00467559
94indolalkylamine catabolic process (GO:0046218)3.00467559
95bundle of His cell to Purkinje myocyte communication (GO:0086069)2.99211170
96lung lobe morphogenesis (GO:0060463)2.99006494
97peptide cross-linking (GO:0018149)2.98020545
98positive regulation of endothelial cell differentiation (GO:0045603)2.97842530
99regulation of cardioblast differentiation (GO:0051890)2.96307002
100cell morphogenesis involved in neuron differentiation (GO:0048667)2.94827203
101metanephric epithelium development (GO:0072207)2.93073313
102iron ion import (GO:0097286)2.92466993
103indolalkylamine metabolic process (GO:0006586)2.92045634
104regulation of protein activation cascade (GO:2000257)2.91691763
105negative regulation of interleukin-2 production (GO:0032703)2.91347953
106endodermal cell differentiation (GO:0035987)2.88038226
107glial cell proliferation (GO:0014009)2.87224437
108atrioventricular valve morphogenesis (GO:0003181)2.86025541
109epithelial tube branching involved in lung morphogenesis (GO:0060441)2.85601227
110mesenchymal cell differentiation involved in renal system development (GO:2001012)2.84244716
111mesenchymal cell differentiation involved in kidney development (GO:0072161)2.84244716
112hypotonic response (GO:0006971)2.84117486
113endocardial cushion development (GO:0003197)2.83701414
114negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.83685170
115respiratory gaseous exchange (GO:0007585)2.82244342
116regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.81853559
117mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.80960866
118renal absorption (GO:0070293)2.80381937
119lung vasculature development (GO:0060426)2.79727298
120negative regulation of protein autophosphorylation (GO:0031953)2.79321038
121wound healing, spreading of epidermal cells (GO:0035313)2.77834335
122toxin transport (GO:1901998)2.76082537
123pattern specification involved in kidney development (GO:0061004)2.75328596
124regulation of cardioblast proliferation (GO:0003264)2.74846854
125regulation of secondary heart field cardioblast proliferation (GO:0003266)2.74846854
126regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.73551437
127membrane protein proteolysis (GO:0033619)2.72951463
128gland morphogenesis (GO:0022612)2.72596504
129glycerol metabolic process (GO:0006071)2.71902314
130epithelial cell morphogenesis (GO:0003382)2.71509547
131interleukin-6-mediated signaling pathway (GO:0070102)2.69439732
132positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.68638487
133diol metabolic process (GO:0034311)2.67376726
134protein localization to endosome (GO:0036010)2.66912100
135regulation of keratinocyte proliferation (GO:0010837)2.66576098
136establishment of tissue polarity (GO:0007164)2.66489125
137establishment of planar polarity (GO:0001736)2.66489125
138negative regulation of lymphocyte apoptotic process (GO:0070229)2.65254678
139water homeostasis (GO:0030104)2.65227367
140tryptophan metabolic process (GO:0006568)2.64962835
141post-embryonic morphogenesis (GO:0009886)2.64607622
142peptide catabolic process (GO:0043171)2.64423666
143desmosome organization (GO:0002934)2.64010213
144lung alveolus development (GO:0048286)2.62474162
145extracellular matrix assembly (GO:0085029)2.62028967
146cellular sodium ion homeostasis (GO:0006883)2.61891677
147response to increased oxygen levels (GO:0036296)2.60206350
148response to hyperoxia (GO:0055093)2.60206350
149negative regulation of stress fiber assembly (GO:0051497)2.58787198
150neuron remodeling (GO:0016322)2.58112483
151developmental induction (GO:0031128)2.55823901
152regulation of glomerular filtration (GO:0003093)2.55130328
153regulation of female gonad development (GO:2000194)2.55068479
154protein destabilization (GO:0031648)2.54801726
155negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.53915483
156regulation of platelet aggregation (GO:0090330)2.53324540
157negative regulation of interleukin-10 production (GO:0032693)2.53060223
158cholesterol efflux (GO:0033344)2.52918966
159fertilization (GO:0009566)2.52843206
160regulation of glucocorticoid metabolic process (GO:0031943)2.51674224
161endothelial cell chemotaxis (GO:0035767)2.51649160
162vascular endothelial growth factor signaling pathway (GO:0038084)2.51508926
163regulation of metalloenzyme activity (GO:0048552)2.51022441
164G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.49624505
165regulation of endothelial cell differentiation (GO:0045601)2.49350944
166blood vessel remodeling (GO:0001974)2.47736010
167smooth muscle tissue development (GO:0048745)2.46236999
168regulation of macrophage chemotaxis (GO:0010758)2.45093468
169regulation of vasculogenesis (GO:2001212)2.42652193
170regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.39758264
171lipid translocation (GO:0034204)2.37250467
172phospholipid translocation (GO:0045332)2.37250467
173extracellular matrix disassembly (GO:0022617)2.36803723
174cell junction assembly (GO:0034329)2.34706921
175positive regulation of digestive system process (GO:0060456)2.32697190
176cell migration involved in heart development (GO:0060973)2.31633343
177import into cell (GO:0098657)2.31377915
178epithelial cell differentiation involved in prostate gland development (GO:0060742)2.30365358
179paraxial mesoderm development (GO:0048339)2.29665320
180endothelial cell morphogenesis (GO:0001886)2.29047340
181neuromuscular junction development (GO:0007528)2.28625239
182regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.28611174
183wound healing (GO:0042060)2.28520131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.29816049
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.85868023
3CDX2_19796622_ChIP-Seq_MESCs_Mouse2.51389666
4EZH2_22144423_ChIP-Seq_EOC_Human2.35382027
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.25673640
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.12938358
7SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.09681655
8SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.09681655
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00658115
10CLOCK_20551151_ChIP-Seq_293T_Human2.00185910
11FLI1_27457419_Chip-Seq_LIVER_Mouse1.97513475
12ZNF217_24962896_ChIP-Seq_MCF-7_Human1.96824969
13TCF4_18268006_ChIP-ChIP_LS174T_Human1.96598735
14SALL1_21062744_ChIP-ChIP_HESCs_Human1.95833360
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94871451
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.94320603
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86972902
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.83382511
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81935180
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80936309
21CDX2_20551321_ChIP-Seq_CACO-2_Human1.80729647
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73559672
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.71179951
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70625171
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.64294773
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63589357
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62948963
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62448425
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61186803
30TP63_23658742_ChIP-Seq_EP156T_Human1.57813211
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.48639919
32TBX20_22328084_ChIP-Seq_HEART_Mouse1.48639919
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.48262318
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46890967
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44100263
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.44082412
37CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43154037
38SOX2_20726797_ChIP-Seq_SW620_Human1.42746019
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42316161
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41378523
41STAT1_17558387_ChIP-Seq_HELA_Human1.39883522
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39242923
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38894365
44SMAD3_21741376_ChIP-Seq_HESCs_Human1.37683331
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.37438349
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34297640
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34275367
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32590227
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.32531249
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31918866
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30955474
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30595203
53AHR_22903824_ChIP-Seq_MCF-7_Human1.30433315
54GATA1_22025678_ChIP-Seq_K562_Human1.30364748
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.27966331
56NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27471072
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27162742
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27162742
59* EZH2_27294783_Chip-Seq_NPCs_Mouse1.27080644
60BRD4_25478319_ChIP-Seq_HGPS_Human1.26492377
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25427037
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24434796
63SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24284881
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24260809
65TP53_16413492_ChIP-PET_HCT116_Human1.24038604
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.23717171
67TP53_18474530_ChIP-ChIP_U2OS_Human1.23697062
68GATA4_25053715_ChIP-Seq_YYC3_Human1.23221196
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22348134
70* AR_21572438_ChIP-Seq_LNCaP_Human1.22336452
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22088396
72P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21708062
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21405754
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21245285
75ESRRB_18555785_Chip-Seq_ESCs_Mouse1.20874159
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19750020
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19053190
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18321656
79SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18280589
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.17838704
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17419778
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16896070
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16734813
84* SMAD4_21741376_ChIP-Seq_HESCs_Human1.16472540
85DROSHA_22980978_ChIP-Seq_HELA_Human1.14840103
86CDX2_22108803_ChIP-Seq_LS180_Human1.14732036
87RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14269459
88EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14269459
89PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13616610
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13482236
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11847737
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.11753164
93JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11406397
94AR_21909140_ChIP-Seq_LNCAP_Human1.10870491
95* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10746217
96* SMAD4_21799915_ChIP-Seq_A2780_Human1.10339721
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09138532
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.08823801
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08415903
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.08276118
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.08238880
102FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07920842
103SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07282045
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06732478
105CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04847720
106* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04004600
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03852412
108JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03671107
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03603116
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02681481
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02318304
112SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01947163
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.01938699
114WT1_19549856_ChIP-ChIP_CCG9911_Human1.01513035
115* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01104756
116CTCF_18555785_Chip-Seq_ESCs_Mouse1.00698094
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.00237398
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00039157
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99630648
120* VDR_24787735_ChIP-Seq_THP-1_Human0.99595647
121RUNX1_27514584_Chip-Seq_MCF-7_Human0.99067589
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98872463
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98773134
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98767086
125* CJUN_26792858_Chip-Seq_BT549_Human0.98210807
126ZFX_18555785_Chip-Seq_ESCs_Mouse0.97959016
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97227969
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97219116
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97015162
130VDR_22108803_ChIP-Seq_LS180_Human0.96725429
131KLF5_25053715_ChIP-Seq_YYC3_Human0.96563443
132JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96382765
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96076545
134P53_22387025_ChIP-Seq_ESCs_Mouse0.95934375
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.94690924
136UBF1/2_26484160_Chip-Seq_HMECs_Human0.94345238
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.94241568
138* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94198998
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94043035
140PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93994325
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.93974027
142NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93547375
143STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93138945
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92441019
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.92002835
146* FOXA2_19822575_ChIP-Seq_HepG2_Human0.89527521
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89269425
148KDM2B_26808549_Chip-Seq_REH_Human0.89147977
149OCT4_18555785_Chip-Seq_ESCs_Mouse0.89005082
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87253948
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81271089
152TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78872193
153SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75608891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog6.30048015
2MP0008995_early_reproductive_senescence5.63384767
3MP0008004_abnormal_stomach_pH5.01607961
4MP0001958_emphysema4.08273601
5MP0000462_abnormal_digestive_system3.59859469
6MP0003252_abnormal_bile_duct3.29758214
7MP0003941_abnormal_skin_development2.67128321
8MP0003705_abnormal_hypodermis_morpholog2.66506246
9MP0005083_abnormal_biliary_tract2.61527403
10MP0010234_abnormal_vibrissa_follicle2.56516228
11MP0008438_abnormal_cutaneous_collagen2.56150889
12MP0001177_atelectasis2.54664028
13MP0003045_fibrosis2.52634135
14MP0002234_abnormal_pharynx_morphology2.45469423
15MP0002138_abnormal_hepatobiliary_system2.42620972
16MP0010678_abnormal_skin_adnexa2.41107093
17MP0003303_peritoneal_inflammation2.38215429
18MP0000383_abnormal_hair_follicle2.29837888
19MP0010352_gastrointestinal_tract_polyps2.27418798
20MP0005388_respiratory_system_phenotype2.02298875
21MP0002133_abnormal_respiratory_system2.02298875
22MP0002139_abnormal_hepatobiliary_system2.00763858
23MP0004185_abnormal_adipocyte_glucose1.99090488
24MP0003191_abnormal_cellular_cholesterol1.91663604
25MP0009384_cardiac_valve_regurgitation1.90125323
26MP0003453_abnormal_keratinocyte_physiol1.89716713
27MP0002060_abnormal_skin_morphology1.89675431
28MP0000537_abnormal_urethra_morphology1.89097181
29MP0001188_hyperpigmentation1.84723669
30MP0005623_abnormal_meninges_morphology1.84325007
31MP0001542_abnormal_bone_strength1.82886061
32MP0005379_endocrine/exocrine_gland_phen1.82513907
33MP0005360_urolithiasis1.72910061
34MP0002168_other_aberrant_phenotype1.72831954
35MP0002249_abnormal_larynx_morphology1.72115011
36MP0001879_abnormal_lymphatic_vessel1.69795726
37MP0005409_darkened_coat_color1.65152422
38MP0005451_abnormal_body_composition1.64872704
39MP0005085_abnormal_gallbladder_physiolo1.57777478
40MP0005408_hypopigmentation1.56828989
41MP0001666_abnormal_nutrient_absorption1.56762073
42MP0002928_abnormal_bile_duct1.55022799
43MP0009780_abnormal_chondrocyte_physiolo1.47977152
44MP0001853_heart_inflammation1.45905481
45MP0010368_abnormal_lymphatic_system1.41886705
46MP0000566_synostosis1.38475571
47MP0003828_pulmonary_edema1.37437378
48MP0004043_abnormal_pH_regulation1.36191204
49MP0000613_abnormal_salivary_gland1.34948669
50MP0004272_abnormal_basement_membrane1.34648916
51MP0005164_abnormal_response_to1.34457343
52MP0006138_congestive_heart_failure1.34440039
53MP0000013_abnormal_adipose_tissue1.33988630
54MP0005220_abnormal_exocrine_pancreas1.32151711
55MP0001216_abnormal_epidermal_layer1.25231119
56MP0001765_abnormal_ion_homeostasis1.22713572
57MP0003279_aneurysm1.22635061
58MP0001661_extended_life_span1.22531928
59MP0004130_abnormal_muscle_cell1.20726391
60MP0010329_abnormal_lipoprotein_level1.19553042
61MP0003385_abnormal_body_wall1.19263957
62MP0005595_abnormal_vascular_smooth1.17995959
63MP0002295_abnormal_pulmonary_circulatio1.17633270
64MP0001849_ear_inflammation1.17180707
65MP0000767_abnormal_smooth_muscle1.11410833
66MP0000534_abnormal_ureter_morphology1.10267119
67MP0004883_abnormal_blood_vessel1.09244104
68MP0004264_abnormal_extraembryonic_tissu1.08398617
69MP0002254_reproductive_system_inflammat1.08140001
70MP0005395_other_phenotype1.08093678
71MP0000467_abnormal_esophagus_morphology1.07955588
72MP0005503_abnormal_tendon_morphology1.06670195
73MP0000377_abnormal_hair_follicle1.05313951
74MP0001175_abnormal_lung_morphology1.04693391
75MP0000003_abnormal_adipose_tissue1.03621358
76MP0001664_abnormal_digestion1.01758447
77MP0000733_abnormal_muscle_development0.99270846
78MP0002136_abnormal_kidney_physiology0.98520640
79MP0003950_abnormal_plasma_membrane0.98361401
80MP0008961_abnormal_basal_metabolism0.97154244
81MP0002098_abnormal_vibrissa_morphology0.96316629
82MP0000685_abnormal_immune_system0.95170066
83MP0001851_eye_inflammation0.94639402
84MP0003786_premature_aging0.93686978
85MP0010030_abnormal_orbit_morphology0.93438138
86MP0002118_abnormal_lipid_homeostasis0.92965436
87MP0005501_abnormal_skin_physiology0.92145255
88MP0003724_increased_susceptibility_to0.92122834
89MP0003183_abnormal_peptide_metabolism0.90205097
90MP0000639_abnormal_adrenal_gland0.90081082
91MP0002796_impaired_skin_barrier0.89590148
92MP0003091_abnormal_cell_migration0.86712681
93MP0005381_digestive/alimentary_phenotyp0.86118304
94MP0005365_abnormal_bile_salt0.85729866
95MP0003195_calcinosis0.85043665
96MP0005375_adipose_tissue_phenotype0.84674549
97MP0003718_maternal_effect0.84254283
98MP0006054_spinal_hemorrhage0.83873883
99MP0005058_abnormal_lysosome_morphology0.83674934
100MP0000678_abnormal_parathyroid_gland0.83486463
101MP0001943_abnormal_respiration0.83051009
102MP0002909_abnormal_adrenal_gland0.82424010
103MP0004145_abnormal_muscle_electrophysio0.82416119
104MP0005165_increased_susceptibility_to0.80496132
105MP0003566_abnormal_cell_adhesion0.79112761
106MP0000579_abnormal_nail_morphology0.78021874
107MP0005084_abnormal_gallbladder_morpholo0.77486269
108MP0002925_abnormal_cardiovascular_devel0.76581484
109MP0005257_abnormal_intraocular_pressure0.76555764
110MP0000427_abnormal_hair_cycle0.75602570
111MP0005666_abnormal_adipose_tissue0.74956582
112MP0002998_abnormal_bone_remodeling0.74480301
113MP0000627_abnormal_mammary_gland0.74470423
114MP0002877_abnormal_melanocyte_morpholog0.74266236
115MP0002405_respiratory_system_inflammati0.73843496
116* MP0005410_abnormal_fertilization0.72984803
117MP0002108_abnormal_muscle_morphology0.72019367
118MP0005166_decreased_susceptibility_to0.71403679
119MP0004084_abnormal_cardiac_muscle0.70521307
120MP0001614_abnormal_blood_vessel0.70189667
121MP0003300_gastrointestinal_ulcer0.69786837
122MP0005023_abnormal_wound_healing0.69591384
123MP0002332_abnormal_exercise_endurance0.67928272
124MP0005275_abnormal_skin_tensile0.67533762
125MP0009643_abnormal_urine_homeostasis0.67336316
126MP0004947_skin_inflammation0.67083517
127MP0005387_immune_system_phenotype0.66862391
128MP0001790_abnormal_immune_system0.66862391
129MP0001440_abnormal_grooming_behavior0.66652008
130MP0003890_abnormal_embryonic-extraembry0.66586306
131MP0002896_abnormal_bone_mineralization0.66308970
132MP0006072_abnormal_retinal_apoptosis0.65898685
133MP0000465_gastrointestinal_hemorrhage0.65794386
134MP0000762_abnormal_tongue_morphology0.65549054
135MP0000249_abnormal_blood_vessel0.64374179
136MP0003448_altered_tumor_morphology0.64113687
137MP0002736_abnormal_nociception_after0.63713287
138MP0004742_abnormal_vestibular_system0.63703292
139MP0003115_abnormal_respiratory_system0.63195259
140MP0005076_abnormal_cell_differentiation0.62913963
141MP0002932_abnormal_joint_morphology0.62323919
142MP0002128_abnormal_blood_circulation0.61245937
143MP0005508_abnormal_skeleton_morphology0.61092347
144MP0009840_abnormal_foam_cell0.60510842
145MP0010771_integument_phenotype0.60034217
146MP0009931_abnormal_skin_appearance0.57877825
147MP0003075_altered_response_to0.57781601
148MP0001243_abnormal_dermal_layer0.52044124
149MP0000681_abnormal_thyroid_gland0.51707222
150MP0005621_abnormal_cell_physiology0.50161508

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)9.01272498
2Tachypnea (HP:0002789)5.95044702
3Tubulointerstitial fibrosis (HP:0005576)5.85327285
4Hyperactive renin-angiotensin system (HP:0000841)5.57298254
5Upper limb muscle weakness (HP:0003484)5.02522977
6Respiratory distress (HP:0002098)4.58783748
7Hyperkalemia (HP:0002153)4.52052371
8Cerebral aneurysm (HP:0004944)4.48230273
9Onycholysis (HP:0001806)4.43888432
10Plantar hyperkeratosis (HP:0007556)4.20037511
11Tubulointerstitial abnormality (HP:0001969)4.19009242
12Abnormality of chloride homeostasis (HP:0011422)4.17869655
13Neurofibrillary tangles (HP:0002185)4.12043093
14Chronic bronchitis (HP:0004469)3.96712688
15Cystic liver disease (HP:0006706)3.79119007
16Tubulointerstitial nephritis (HP:0001970)3.75208497
17Scanning speech (HP:0002168)3.65866801
18Popliteal pterygium (HP:0009756)3.65727555
19Gout (HP:0001997)3.62876353
20Right ventricular cardiomyopathy (HP:0011663)3.58705389
21Lip pit (HP:0100267)3.57714769
22Stomach cancer (HP:0012126)3.53811037
23Renal salt wasting (HP:0000127)3.45984684
24Abnormality of the renal cortex (HP:0011035)3.43826686
25Renal cortical cysts (HP:0000803)3.40098626
26Abnormality of the parathyroid morphology (HP:0011766)3.39185670
27Neonatal respiratory distress (HP:0002643)3.30105306
28Cerebral inclusion bodies (HP:0100314)3.28436918
29Osteolytic defects of the phalanges of the hand (HP:0009771)3.20915033
30Osteolytic defects of the hand bones (HP:0009699)3.20915033
31Thick nail (HP:0001805)3.16832758
32Abnormality of the fingertips (HP:0001211)3.15049874
33Alopecia of scalp (HP:0002293)3.15021932
34Glomerulosclerosis (HP:0000096)3.14950789
35Atrophic scars (HP:0001075)3.12796740
36Autoimmune thrombocytopenia (HP:0001973)3.05528643
37Congenital stationary night blindness (HP:0007642)3.01710892
38Nail dystrophy (HP:0008404)2.99554076
39Hyperaldosteronism (HP:0000859)2.92154857
40Tetany (HP:0001281)2.90321172
41Arterial tortuosity (HP:0005116)2.89141885
42Vascular tortuosity (HP:0004948)2.86152711
43Unilateral renal agenesis (HP:0000122)2.82745326
44Complement deficiency (HP:0004431)2.75428009
45Abnormality of nail color (HP:0100643)2.74339260
46Abnormality of renin-angiotensin system (HP:0000847)2.73275975
47Aortic aneurysm (HP:0004942)2.72267828
48Aortic dissection (HP:0002647)2.71748509
49Fragile skin (HP:0001030)2.71190854
50Supranuclear gaze palsy (HP:0000605)2.70711457
51Milia (HP:0001056)2.65335906
52Thyroid-stimulating hormone excess (HP:0002925)2.60768979
53Pterygium (HP:0001059)2.60212041
54Palmoplantar hyperkeratosis (HP:0000972)2.57400697
55Loss of speech (HP:0002371)2.50425327
56Facial shape deformation (HP:0011334)2.50246636
57Potter facies (HP:0002009)2.50246636
58Abnormality of the neuromuscular junction (HP:0003398)2.42463863
59Fatigable weakness (HP:0003473)2.42463863
60Abnormality of complement system (HP:0005339)2.42290814
61Glomerulonephritis (HP:0000099)2.42115496
62Palmar hyperkeratosis (HP:0010765)2.41604682
63Nephroblastoma (Wilms tumor) (HP:0002667)2.40640015
64Dynein arm defect of respiratory motile cilia (HP:0012255)2.39830853
65Absent/shortened dynein arms (HP:0200106)2.39830853
66Premature rupture of membranes (HP:0001788)2.34790536
67Fragile nails (HP:0001808)2.33811516
68Stage 5 chronic kidney disease (HP:0003774)2.32276423
69Hyperuricemia (HP:0002149)2.31544825
70Increased purine levels (HP:0004368)2.31544825
71Nephritis (HP:0000123)2.31541544
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30580480
73Abnormality of purine metabolism (HP:0004352)2.28463200
74Prostate neoplasm (HP:0100787)2.23173805
75Striae distensae (HP:0001065)2.23111066
76Natal tooth (HP:0000695)2.22914482
77Pulmonary hypertension (HP:0002092)2.19363262
78Embryonal renal neoplasm (HP:0011794)2.18989254
79Tubular atrophy (HP:0000092)2.18106348
80Hyperparathyroidism (HP:0000843)2.18067740
81Dehydration (HP:0001944)2.15579744
82Hypotrichosis (HP:0001006)2.13881338
83Embryonal neoplasm (HP:0002898)2.11276853
84Aneurysm (HP:0002617)2.09807212
85Genetic anticipation (HP:0003743)2.07029411
86Ridged nail (HP:0001807)2.06655946
87Ankyloglossia (HP:0010296)2.04399789
88Adrenal hypoplasia (HP:0000835)2.04345505
89Abnormal blistering of the skin (HP:0008066)2.02675530
90Subcapsular cataract (HP:0000523)2.02489319
91Alveolar cell carcinoma (HP:0006519)2.00432102
92Pili torti (HP:0003777)1.99413198
93Hypophosphatemic rickets (HP:0004912)1.99398614
94Nasolacrimal duct obstruction (HP:0000579)1.99031975
95Abnormality of macrophages (HP:0004311)1.97009605
96Aplasia cutis congenita (HP:0001057)1.95669337
97Camptodactyly of toe (HP:0001836)1.94432864
98Amniotic constriction ring (HP:0009775)1.90072438
99Abnormality of placental membranes (HP:0011409)1.90072438
100Abnormal hemoglobin (HP:0011902)1.89599997
101Wormian bones (HP:0002645)1.89219506
102Xerostomia (HP:0000217)1.87394793
103Sensorimotor neuropathy (HP:0007141)1.87185987
104Neoplasm of the adrenal cortex (HP:0100641)1.87115493
105Progressive muscle weakness (HP:0003323)1.86355199
106Aplasia of the musculature (HP:0100854)1.86034351
107Abnormality of the lacrimal duct (HP:0011481)1.85793414
108Neoplasm of the tracheobronchial system (HP:0100552)1.85670390
109Shallow orbits (HP:0000586)1.84858409
110Hypoplastic labia majora (HP:0000059)1.84043820
111Systemic lupus erythematosus (HP:0002725)1.83787406
112Advanced eruption of teeth (HP:0006288)1.83333724
113Focal segmental glomerulosclerosis (HP:0000097)1.83138520
114Polycystic kidney dysplasia (HP:0000113)1.83093610
115Malnutrition (HP:0004395)1.82938803
116Abnormality of potassium homeostasis (HP:0011042)1.82257547
117Hoarse voice (HP:0001609)1.81875686
118Vascular calcification (HP:0004934)1.81196522
119Abnormality of the renal collecting system (HP:0004742)1.80996409
120Mitral stenosis (HP:0001718)1.80987916
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78553931
122Postural instability (HP:0002172)1.78382116
123Pustule (HP:0200039)1.77685463
124Abnormality of the labia majora (HP:0012881)1.77133928
125Periodontitis (HP:0000704)1.76793974
126Chromsome breakage (HP:0040012)1.76405670
127Cardiovascular calcification (HP:0011915)1.76151140
128Congenital sensorineural hearing impairment (HP:0008527)1.75900146
129Wrist flexion contracture (HP:0001239)1.74404037
130Abnormality of the renal medulla (HP:0100957)1.73653695
131Hypotension (HP:0002615)1.73527304
132Acne (HP:0001061)1.72595048
133Hypodontia (HP:0000668)1.72516517
134Prolonged neonatal jaundice (HP:0006579)1.71889957
135Abnormality of the nasolacrimal system (HP:0000614)1.71206453
136Lower limb amyotrophy (HP:0007210)1.70712499
137Rectal prolapse (HP:0002035)1.70596909
138Abnormality of the peritoneum (HP:0002585)1.69596655
139Corneal erosion (HP:0200020)1.68532313
140Down-sloping shoulders (HP:0200021)1.68503332
141Pulmonary artery stenosis (HP:0004415)1.67996428
142Mitral valve prolapse (HP:0001634)1.65655947
143Growth hormone excess (HP:0000845)1.65440127
144Glucose intolerance (HP:0000833)1.65058174
145Humeroradial synostosis (HP:0003041)1.62344021
146Synostosis involving the elbow (HP:0003938)1.62344021
147Abnormality of oral frenula (HP:0000190)1.60367744
148Follicular hyperkeratosis (HP:0007502)1.60171471
149Absent hand (HP:0004050)1.59744599
150Increased CSF protein (HP:0002922)1.58950348
151Ulnar claw (HP:0001178)1.58893634
152Polycythemia (HP:0001901)1.58603179
153True hermaphroditism (HP:0010459)1.58024430
154Distal lower limb muscle weakness (HP:0009053)1.57853011
155Abnormality of the gastric mucosa (HP:0004295)1.57638516
156Tibial bowing (HP:0002982)1.57135812
157Stenosis of the external auditory canal (HP:0000402)1.56955919
158Reduced subcutaneous adipose tissue (HP:0003758)1.56328602
159Pulmonary fibrosis (HP:0002206)1.56237892
160Midline defect of the nose (HP:0004122)1.56067960
161Male pseudohermaphroditism (HP:0000037)1.54932702
162Flat acetabular roof (HP:0003180)1.54196883
163Short nail (HP:0001799)1.54136040
164Abnormality of the salivary glands (HP:0010286)1.53518987
165Polar cataract (HP:0010696)1.52029804
166Bronchiectasis (HP:0002110)1.50486014
167Mediastinal lymphadenopathy (HP:0100721)1.50362140
168Breast carcinoma (HP:0003002)1.49822221
169Subacute progressive viral hepatitis (HP:0006572)1.47574382
170Febrile seizures (HP:0002373)1.47315052
171Chronic hepatic failure (HP:0100626)1.47290713
172Hemiplegia (HP:0002301)1.47284019
173Absent eyebrow (HP:0002223)1.45055015
174Hypoplasia of dental enamel (HP:0006297)1.44704551
175Adrenal overactivity (HP:0002717)1.44670576
176Decreased circulating renin level (HP:0003351)1.44161582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.60173413
2MAP3K94.07909212
3ZAK4.07778475
4GRK13.92765099
5LATS13.28162896
6LMTK23.22341991
7STK393.05206805
8WNK42.80999602
9MST1R2.29579583
10TIE12.24097745
11NTRK32.20164750
12TTK2.11925917
13MST42.02953198
14FRK1.86075787
15STK241.82627083
16ARAF1.80090010
17MAP3K131.73180915
18FGFR21.71287654
19PRKCH1.66491350
20MAP3K21.63965805
21FGFR41.60446699
22MOS1.51107847
23STK38L1.49091330
24MAPK151.39558633
25EPHB21.38592354
26MET1.36452434
27FGFR31.34711431
28LRRK21.33365465
29MUSK1.33157173
30CAMK1D1.31359729
31TRIB31.28137832
32CDC42BPA1.21705248
33RPS6KA21.20924386
34MATK1.18616555
35RIPK11.16561608
36TNIK1.16532943
37PDGFRB1.14505759
38TRPM71.14021053
39PRPF4B1.13708470
40NEK61.09984962
41FER1.08416201
42MAP3K71.07912619
43TAOK11.07336986
44WNK11.05472872
45EEF2K1.00443926
46MELK0.99818860
47NLK0.98580389
48PTK20.96672413
49JAK10.96278409
50FLT30.96224792
51ERN10.96197186
52TGFBR10.94845457
53PRKAA20.94377028
54TYRO30.93689678
55STK30.91684176
56CDK120.91429773
57TTN0.91402365
58DMPK0.87531339
59CSK0.85655819
60ERBB20.84539533
61MARK20.83648221
62EPHA20.81781285
63AKT30.81694268
64TXK0.80156651
65GSK3A0.80061491
66TEC0.77992481
67EPHB10.76466769
68STK380.74411549
69MAPKAPK30.74388953
70CDK90.73694745
71PRKCQ0.71901253
72PAK20.69680357
73NEK90.68600241
74NUAK10.68005583
75CHUK0.67649155
76LATS20.67619225
77MAP2K10.66901715
78PDPK10.66461931
79SGK30.66330834
80PRKCE0.65660443
81CAMK1G0.64769376
82OXSR10.64286815
83DAPK20.63922699
84MTOR0.62835933
85PRKD20.62292894
86PTK60.61404064
87EPHA30.60771156
88SIK10.60182779
89FES0.60082183
90ERBB40.58879559
91SGK20.56674001
92KSR20.55969404
93ILK0.55428452
94CASK0.53645214
95ABL10.52824941
96BCR0.52282899
97MAP2K60.50190542
98IRAK10.49381004
99PKN20.49312896
100ICK0.49106283
101MAP3K30.48370430
102CDK60.48295929
103PAK30.47051792
104MAP3K60.46918857
105BRSK20.45704852
106INSRR0.45682557
107ZAP700.44740012
108CDK30.43789854
109RET0.43335945
110PRKD10.43275289
111KDR0.42792182
112EGFR0.42451466
113CSNK1E0.41940009
114BLK0.41643431
115MAP3K120.41230709
116ROCK20.40250007
117ALK0.39032752
118MAP3K10.38593171
119IGF1R0.38519234
120YES10.38310844
121PAK40.38257303
122SGK10.37893568
123PIK3CA0.37360133
124ROCK10.37239259
125MAP3K140.37174995
126PRKACA0.37057214
127CLK10.35537074
128TYK20.35516772
129PRKG20.35381140
130PDGFRA0.34772549
131PIK3CG0.32792726
132MAPK70.32194397
133MAPKAPK20.31742741
134CSNK1G10.31368398
135RPS6KL10.31024211
136RPS6KC10.31024211
137RAF10.29183106
138NTRK10.28992576
139PRKCD0.28873973
140CAMK2G0.28318221
141EIF2AK20.27782753
142MYLK0.27621102
143TGFBR20.27061562
144MAPK110.26406350
145RPS6KA40.26373419
146STK100.26137483
147* INSR0.25942290
148PRKACG0.25449180
149SGK2230.24580134

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049783.41217675
2Tryptophan metabolism_Homo sapiens_hsa003802.95303102
3Vitamin B6 metabolism_Homo sapiens_hsa007502.68284091
4Glutathione metabolism_Homo sapiens_hsa004802.59252656
5Nitrogen metabolism_Homo sapiens_hsa009102.49858784
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.22947172
7Thyroid hormone synthesis_Homo sapiens_hsa049182.21480006
8Complement and coagulation cascades_Homo sapiens_hsa046102.13710464
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.03811924
10Pertussis_Homo sapiens_hsa051332.00023667
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.89498077
12ABC transporters_Homo sapiens_hsa020101.88737752
13ECM-receptor interaction_Homo sapiens_hsa045121.69717952
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68579514
15Sphingolipid metabolism_Homo sapiens_hsa006001.68569474
16Arachidonic acid metabolism_Homo sapiens_hsa005901.64066833
17Phagosome_Homo sapiens_hsa041451.53794371
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.51962697
19Fatty acid biosynthesis_Homo sapiens_hsa000611.51203290
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.49863143
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45941902
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45539339
23Fatty acid degradation_Homo sapiens_hsa000711.42018253
24Gastric acid secretion_Homo sapiens_hsa049711.40079079
25Toxoplasmosis_Homo sapiens_hsa051451.38622108
26Staphylococcus aureus infection_Homo sapiens_hsa051501.35966036
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35325210
28Renal cell carcinoma_Homo sapiens_hsa052111.34981832
29Circadian rhythm_Homo sapiens_hsa047101.33881055
30Lysosome_Homo sapiens_hsa041421.33690427
31Adherens junction_Homo sapiens_hsa045201.32529886
32Dorso-ventral axis formation_Homo sapiens_hsa043201.23995418
33TGF-beta signaling pathway_Homo sapiens_hsa043501.22523206
34African trypanosomiasis_Homo sapiens_hsa051431.18558372
35Protein digestion and absorption_Homo sapiens_hsa049741.16203262
36Tight junction_Homo sapiens_hsa045301.15183057
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14095294
38Fatty acid metabolism_Homo sapiens_hsa012121.13144686
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.12681307
40beta-Alanine metabolism_Homo sapiens_hsa004101.11560761
41PI3K-Akt signaling pathway_Homo sapiens_hsa041511.09963435
42Sulfur metabolism_Homo sapiens_hsa009201.09746750
43Taste transduction_Homo sapiens_hsa047421.09711170
44Salivary secretion_Homo sapiens_hsa049701.08387262
45Prion diseases_Homo sapiens_hsa050201.08324783
46Bile secretion_Homo sapiens_hsa049761.07848926
47Fat digestion and absorption_Homo sapiens_hsa049751.06346468
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05831779
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04661767
50Phototransduction_Homo sapiens_hsa047441.03881552
51Malaria_Homo sapiens_hsa051441.02272343
52Histidine metabolism_Homo sapiens_hsa003401.00627861
53Notch signaling pathway_Homo sapiens_hsa043300.95575627
54MicroRNAs in cancer_Homo sapiens_hsa052060.93355854
55Estrogen signaling pathway_Homo sapiens_hsa049150.92387636
56Pathways in cancer_Homo sapiens_hsa052000.92274829
57Pancreatic cancer_Homo sapiens_hsa052120.90994347
58PPAR signaling pathway_Homo sapiens_hsa033200.86928291
59Hippo signaling pathway_Homo sapiens_hsa043900.86559361
60Fatty acid elongation_Homo sapiens_hsa000620.84511867
61Thyroid cancer_Homo sapiens_hsa052160.84479698
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84243919
63Focal adhesion_Homo sapiens_hsa045100.84114903
64Vitamin digestion and absorption_Homo sapiens_hsa049770.83838898
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81919594
66Chronic myeloid leukemia_Homo sapiens_hsa052200.81142342
67Viral myocarditis_Homo sapiens_hsa054160.79061661
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78831485
69Starch and sucrose metabolism_Homo sapiens_hsa005000.78694214
70Arginine biosynthesis_Homo sapiens_hsa002200.75531550
71Butanoate metabolism_Homo sapiens_hsa006500.75010462
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73651827
73Gap junction_Homo sapiens_hsa045400.71832420
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.71263152
75Small cell lung cancer_Homo sapiens_hsa052220.71132336
76Ether lipid metabolism_Homo sapiens_hsa005650.70880287
77Ovarian steroidogenesis_Homo sapiens_hsa049130.70159859
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68531209
79Basal cell carcinoma_Homo sapiens_hsa052170.67720834
80Bladder cancer_Homo sapiens_hsa052190.67479786
81Platelet activation_Homo sapiens_hsa046110.67120954
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66816812
83GnRH signaling pathway_Homo sapiens_hsa049120.66197430
84Endometrial cancer_Homo sapiens_hsa052130.65648526
85Melanogenesis_Homo sapiens_hsa049160.64076826
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63383914
87VEGF signaling pathway_Homo sapiens_hsa043700.63138430
88Lysine degradation_Homo sapiens_hsa003100.62998599
89Endocytosis_Homo sapiens_hsa041440.62912040
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62181057
91Insulin resistance_Homo sapiens_hsa049310.61351003
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60621185
93Dilated cardiomyopathy_Homo sapiens_hsa054140.59620357
94Glycerolipid metabolism_Homo sapiens_hsa005610.59343738
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59279609
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58513139
97Choline metabolism in cancer_Homo sapiens_hsa052310.57967634
98Hepatitis C_Homo sapiens_hsa051600.57960903
99Leishmaniasis_Homo sapiens_hsa051400.57376650
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56687209
101mTOR signaling pathway_Homo sapiens_hsa041500.55446360
102Amoebiasis_Homo sapiens_hsa051460.55251667
103Influenza A_Homo sapiens_hsa051640.55128825
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54564341
105ErbB signaling pathway_Homo sapiens_hsa040120.54102314
106Renin-angiotensin system_Homo sapiens_hsa046140.54083804
107Inositol phosphate metabolism_Homo sapiens_hsa005620.53598872
108Insulin secretion_Homo sapiens_hsa049110.53473593
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53358700
110TNF signaling pathway_Homo sapiens_hsa046680.53195927
111Retinol metabolism_Homo sapiens_hsa008300.53160881
112Type II diabetes mellitus_Homo sapiens_hsa049300.52477871
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52444080
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.51944033
115Asthma_Homo sapiens_hsa053100.51872840
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.51049553
117Long-term depression_Homo sapiens_hsa047300.50606218
118Hematopoietic cell lineage_Homo sapiens_hsa046400.50450985
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49997418
120Pancreatic secretion_Homo sapiens_hsa049720.49430258
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49212664
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48120935
123Prostate cancer_Homo sapiens_hsa052150.47575505
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47497566
125Ras signaling pathway_Homo sapiens_hsa040140.47155321
126Chemical carcinogenesis_Homo sapiens_hsa052040.46829025
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.46578272
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46483959
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46056535
130Apoptosis_Homo sapiens_hsa042100.45631083
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.45366704
132p53 signaling pathway_Homo sapiens_hsa041150.44775336
133Insulin signaling pathway_Homo sapiens_hsa049100.43930102
134Selenocompound metabolism_Homo sapiens_hsa004500.43917366
135Axon guidance_Homo sapiens_hsa043600.43541828
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.43452633
137MAPK signaling pathway_Homo sapiens_hsa040100.41514080
138Oxytocin signaling pathway_Homo sapiens_hsa049210.40819989
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40523361
140Renin secretion_Homo sapiens_hsa049240.39832685
141Cocaine addiction_Homo sapiens_hsa050300.38917700
142Arginine and proline metabolism_Homo sapiens_hsa003300.38641108
143cAMP signaling pathway_Homo sapiens_hsa040240.37720672
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37531932
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.37261058
146Rap1 signaling pathway_Homo sapiens_hsa040150.35213663
147Proteoglycans in cancer_Homo sapiens_hsa052050.34813940
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34511677
149Morphine addiction_Homo sapiens_hsa050320.32909120
150Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32383571
151Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32320511
152Cholinergic synapse_Homo sapiens_hsa047250.32158358
153Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31381108
154FoxO signaling pathway_Homo sapiens_hsa040680.30593537

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