RP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found, which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However, the biological validity and full-length nature of some variants cannot be determined at this time. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* detection of light stimulus (GO:0009583)9.86016388
2* detection of visible light (GO:0009584)9.72570218
3* axoneme assembly (GO:0035082)9.45443608
4* visual perception (GO:0007601)8.99224793
5protein-chromophore linkage (GO:0018298)8.90232035
6* sensory perception of light stimulus (GO:0050953)8.88615722
7regulation of cilium movement (GO:0003352)8.79992161
8left/right pattern formation (GO:0060972)8.79437310
9ventricular system development (GO:0021591)8.44573497
10* retinal rod cell development (GO:0046548)8.19265384
11eye photoreceptor cell differentiation (GO:0001754)8.13037710
12photoreceptor cell differentiation (GO:0046530)8.13037710
13positive regulation of guanylate cyclase activity (GO:0031284)7.93379335
14left/right axis specification (GO:0070986)7.82307955
15retina development in camera-type eye (GO:0060041)7.16669534
16regulation of guanylate cyclase activity (GO:0031282)7.15820661
17* cellular response to light stimulus (GO:0071482)7.00423474
18* detection of external stimulus (GO:0009581)6.88921115
19* detection of abiotic stimulus (GO:0009582)6.74617035
20intraciliary transport (GO:0042073)6.19110271
21* cilium organization (GO:0044782)5.75059732
22cilium assembly (GO:0042384)5.72819146
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.71687638
24primary alcohol catabolic process (GO:0034310)5.60749624
25* microtubule bundle formation (GO:0001578)5.48755392
26regulation of cGMP metabolic process (GO:0030823)5.37285015
27vitamin transmembrane transport (GO:0035461)5.25231363
28microtubule-based movement (GO:0007018)5.16402159
29adaptation of signaling pathway (GO:0023058)5.11322715
30regulation of microtubule-based movement (GO:0060632)4.99398959
31nonmotile primary cilium assembly (GO:0035058)4.91420143
32protein localization to cilium (GO:0061512)4.86047472
33diterpenoid biosynthetic process (GO:0016102)4.84812985
34ethanol metabolic process (GO:0006067)4.71452683
35positive regulation of cGMP biosynthetic process (GO:0030828)4.71356331
36regulation of clathrin-mediated endocytosis (GO:2000369)4.63887395
37lateral ventricle development (GO:0021670)4.57778838
38* cellular component assembly involved in morphogenesis (GO:0010927)4.54797619
39retina layer formation (GO:0010842)4.53997882
40cilium morphogenesis (GO:0060271)4.48079511
41* cellular response to radiation (GO:0071478)4.46086434
42regulation of cGMP biosynthetic process (GO:0030826)4.41849530
43regulation of interleukin-5 production (GO:0032674)4.40846887
44response to xenobiotic stimulus (GO:0009410)4.29852349
45estrogen biosynthetic process (GO:0006703)4.21441789
46positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.20677543
47* sensory perception (GO:0007600)4.20108277
48regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.17035940
49regulation of short-term neuronal synaptic plasticity (GO:0048172)4.15983327
50positive regulation of cGMP metabolic process (GO:0030825)4.13525134
51receptor guanylyl cyclase signaling pathway (GO:0007168)4.11773333
52cell morphogenesis involved in neuron differentiation (GO:0048667)4.10586450
53negative regulation of humoral immune response (GO:0002921)4.05526303
54peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.04210024
55one-carbon compound transport (GO:0019755)4.02811805
56* cell projection assembly (GO:0030031)4.01565987
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.01240805
58microtubule depolymerization (GO:0007019)3.93436886
59detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.87651317
60regulation of voltage-gated calcium channel activity (GO:1901385)3.86368034
61* response to light stimulus (GO:0009416)3.82034745
62centriole assembly (GO:0098534)3.78826192
63lung epithelium development (GO:0060428)3.71941845
64pyrimidine-containing compound transmembrane transport (GO:0072531)3.71680348
65microtubule polymerization or depolymerization (GO:0031109)3.60180020
66* neuron development (GO:0048666)3.57630984
67prenylation (GO:0097354)3.57073602
68protein prenylation (GO:0018342)3.57073602
69protein localization to synapse (GO:0035418)3.52407637
70cytoplasmic microtubule organization (GO:0031122)3.50190621
71ethanol oxidation (GO:0006069)3.44994417
72negative regulation of receptor-mediated endocytosis (GO:0048261)3.43301720
73exogenous drug catabolic process (GO:0042738)3.40272484
74glomerular epithelial cell development (GO:0072310)3.35305701
75sperm capacitation (GO:0048240)3.34995808
76determination of left/right symmetry (GO:0007368)3.33702325
77CDP-diacylglycerol biosynthetic process (GO:0016024)3.33552659
78retina homeostasis (GO:0001895)3.33529602
79O-glycan processing (GO:0016266)3.33186782
80synaptic vesicle docking involved in exocytosis (GO:0016081)3.31502179
81membrane hyperpolarization (GO:0060081)3.25958178
82determination of bilateral symmetry (GO:0009855)3.25177304
83retinoic acid metabolic process (GO:0042573)3.24239789
84lipid translocation (GO:0034204)3.23201384
85phospholipid translocation (GO:0045332)3.23201384
86tolerance induction (GO:0002507)3.22526329
87negative regulation of immunoglobulin mediated immune response (GO:0002890)3.19393352
88negative regulation of B cell mediated immunity (GO:0002713)3.19393352
89synaptic vesicle maturation (GO:0016188)3.19175257
90specification of symmetry (GO:0009799)3.18518395
91retinoid metabolic process (GO:0001523)3.17385426
92positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.16181806
93nucleoside diphosphate phosphorylation (GO:0006165)3.11604052
94terpenoid biosynthetic process (GO:0016114)3.10795506
95positive regulation of neurotransmitter transport (GO:0051590)3.10794042
96regulation of germinal center formation (GO:0002634)3.09500946
97regulation of interleukin-13 production (GO:0032656)3.07811138
98phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.07580926
99negative regulation of T cell differentiation in thymus (GO:0033085)3.05860920
100CDP-diacylglycerol metabolic process (GO:0046341)3.04433141
101lateral sprouting from an epithelium (GO:0060601)3.02671902
102positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.02542873
103establishment of apical/basal cell polarity (GO:0035089)3.02348144
104cilium or flagellum-dependent cell motility (GO:0001539)22.2686800
105axonemal dynein complex assembly (GO:0070286)20.3616394
106diterpenoid metabolic process (GO:0016101)2.94527081
107positive regulation of sodium ion transmembrane transport (GO:1902307)2.93733328
108* microtubule-based process (GO:0007017)2.89899764
109negative regulation of inclusion body assembly (GO:0090084)2.88599361
110positive regulation of tolerance induction (GO:0002645)2.88522814
111negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.87500377
112cellular potassium ion homeostasis (GO:0030007)2.86608295
113establishment of tissue polarity (GO:0007164)2.86281852
114establishment of planar polarity (GO:0001736)2.86281852
115drug catabolic process (GO:0042737)2.83602319
116apical protein localization (GO:0045176)2.83233616
117short-term memory (GO:0007614)2.82624818
118response to pheromone (GO:0019236)2.79952923
119sperm motility (GO:0030317)2.79883602
120chemosensory behavior (GO:0007635)2.79584141
121behavioral response to ethanol (GO:0048149)2.79291723
122positive regulation of smoothened signaling pathway (GO:0045880)2.76082766
123vitamin A metabolic process (GO:0006776)2.73970914
124lipoprotein transport (GO:0042953)2.70415136
125terpenoid metabolic process (GO:0006721)2.68958938
126smoothened signaling pathway (GO:0007224)2.68494982
127regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.68179382
128regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.68179382
129establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.65365390
130mitochondrion transport along microtubule (GO:0047497)2.65365390
131dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.64850063
132response to histamine (GO:0034776)2.64155078
133negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.63399988
134lactate metabolic process (GO:0006089)2.62684022
135heart looping (GO:0001947)2.62403957
136sodium ion export (GO:0071436)2.61211835
137post-embryonic morphogenesis (GO:0009886)2.59996743
138potassium ion homeostasis (GO:0055075)2.59917040
139retinol metabolic process (GO:0042572)2.59270071
140* response to radiation (GO:0009314)2.57841421
141glutathione derivative metabolic process (GO:1901685)2.57765127
142glutathione derivative biosynthetic process (GO:1901687)2.57765127
143establishment or maintenance of monopolar cell polarity (GO:0061339)2.54652487
144establishment of monopolar cell polarity (GO:0061162)2.54652487
145brain morphogenesis (GO:0048854)2.51909726
146organelle assembly (GO:0070925)2.51326221
147regulation of penile erection (GO:0060405)2.50883365
148positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.50151917
149multicellular organismal water homeostasis (GO:0050891)2.50098244
150protein O-linked glycosylation (GO:0006493)2.48268645
151regulation of synaptic vesicle exocytosis (GO:2000300)2.48187949
152regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.47940867
153negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47628870
154primary alcohol metabolic process (GO:0034308)2.47378154
155dopamine receptor signaling pathway (GO:0007212)2.45037607
156microtubule severing (GO:0051013)2.44158239
157excretion (GO:0007588)2.43415488
158iron ion import (GO:0097286)2.41959329
159icosanoid secretion (GO:0032309)2.39332031
160arachidonic acid secretion (GO:0050482)2.39332031
161metanephric mesenchyme development (GO:0072075)2.37604136
162hepatocyte differentiation (GO:0070365)2.36625679
163embryonic heart tube morphogenesis (GO:0003143)2.35071818
164righting reflex (GO:0060013)2.33362050
165positive regulation of vesicle fusion (GO:0031340)2.33180685
166establishment of mitochondrion localization (GO:0051654)2.31996482
167negative regulation of cation channel activity (GO:2001258)2.31675526
168asymmetric protein localization (GO:0008105)2.31086420
169myoblast migration (GO:0051451)2.30334042
170negative regulation of calcium ion transmembrane transport (GO:1903170)2.26979018
171negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.26979018
172positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.26800481
173regulation of microtubule depolymerization (GO:0031114)2.21576431
174regulation of smoothened signaling pathway (GO:0008589)2.20894009
175hypotonic response (GO:0006971)2.19682571
176hydrogen peroxide biosynthetic process (GO:0050665)2.19582663
177gas transport (GO:0015669)2.18476679
178sodium ion homeostasis (GO:0055078)2.17210209
179multicellular organismal aging (GO:0010259)2.17031368
180calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.16379873
181centriole replication (GO:0007099)2.15884114
182regulation of rhodopsin mediated signaling pathway (GO:0022400)17.5966857
183cilium movement (GO:0003341)17.2567403
184rhodopsin mediated signaling pathway (GO:0016056)17.2347947
185epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)16.7503050
186motile cilium assembly (GO:0044458)15.5255418
187epithelial cilium movement (GO:0003351)13.9068290
188* photoreceptor cell development (GO:0042461)12.2438174
189* photoreceptor cell maintenance (GO:0045494)11.7942597
190* eye photoreceptor cell development (GO:0042462)11.4340700
191* retinal cone cell development (GO:0046549)10.9360381
192detection of light stimulus involved in visual perception (GO:0050908)10.8708166
193detection of light stimulus involved in sensory perception (GO:0050962)10.8708166
194* phototransduction (GO:0007602)10.3756742
195GMP metabolic process (GO:0046037)10.2794125
196* phototransduction, visible light (GO:0007603)10.1472193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.22324980
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.98261776
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.95622006
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.32142173
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.08941073
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.88902841
7GBX2_23144817_ChIP-Seq_PC3_Human2.69895604
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.58611640
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.56620258
10DROSHA_22980978_ChIP-Seq_HELA_Human2.32397462
11PIAS1_25552417_ChIP-Seq_VCAP_Human2.27616225
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19659836
13DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.10067886
14FOXM1_26456572_ChIP-Seq_MCF-7_Human2.09736727
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.04944076
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04164914
17BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.96173229
18VDR_22108803_ChIP-Seq_LS180_Human1.89605211
19* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87804411
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80591420
21NR3C1_21868756_ChIP-Seq_MCF10A_Human1.79635546
22SMAD3_21741376_ChIP-Seq_HESCs_Human1.76707822
23KDM2B_26808549_Chip-Seq_K562_Human1.76152361
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.73073527
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70256008
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.69317275
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.67509096
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66971845
29AR_21572438_ChIP-Seq_LNCaP_Human1.65471565
30CTNNB1_20460455_ChIP-Seq_HCT116_Human1.63400968
31REST_21632747_ChIP-Seq_MESCs_Mouse1.62621065
32AR_19668381_ChIP-Seq_PC3_Human1.61853120
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61206769
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61034375
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59318856
36P53_22127205_ChIP-Seq_FIBROBLAST_Human1.59156789
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58444067
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58429845
39TP63_23658742_ChIP-Seq_EP156T_Human1.57438219
40AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.56668427
41FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.55228141
42* EZH2_27294783_Chip-Seq_ESCs_Mouse1.54315098
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.53951447
44TP53_16413492_ChIP-PET_HCT116_Human1.52329590
45TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.50797234
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.50397076
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48724765
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47997884
49TP53_18474530_ChIP-ChIP_U2OS_Human1.47203965
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46155497
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.45143684
52SMAD4_21799915_ChIP-Seq_A2780_Human1.44411366
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43428890
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42460769
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42460769
56ETV1_20927104_ChIP-Seq_GIST48_Human1.42015686
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40062671
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.40060352
59TBL1_22424771_ChIP-Seq_293T_Human1.38162243
60PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.36306000
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36240351
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.35820253
63IGF1R_20145208_ChIP-Seq_DFB_Human1.35079257
64SMRT_27268052_Chip-Seq_Bcells_Human1.34112606
65FOXA1_25552417_ChIP-Seq_VCAP_Human1.33247783
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32564737
67CTCF_27219007_Chip-Seq_Bcells_Human1.32530467
68* SMAD3_21741376_ChIP-Seq_EPCs_Human1.31487450
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31399014
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30511808
71STAT3_23295773_ChIP-Seq_U87_Human1.30337894
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.29018388
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.28883590
74* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28801504
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.28393573
76BCAT_22108803_ChIP-Seq_LS180_Human1.25990886
77CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.25902236
78TCF4_22108803_ChIP-Seq_LS180_Human1.25813199
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25417775
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25315933
81PHF8_20622853_ChIP-Seq_HELA_Human1.24245766
82WDR5_24793694_ChIP-Seq_LNCAP_Human1.23034609
83SMC4_20622854_ChIP-Seq_HELA_Human1.21995671
84NFYA_21822215_ChIP-Seq_K562_Human1.21981161
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.21663174
86GATA4_25053715_ChIP-Seq_YYC3_Human1.19324315
87DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18968372
88KLF5_25053715_ChIP-Seq_YYC3_Human1.18903160
89ER_23166858_ChIP-Seq_MCF-7_Human1.18010662
90NFYB_21822215_ChIP-Seq_K562_Human1.17883258
91CREB1_26743006_Chip-Seq_LNCaP_Human1.16545120
92HNFA_21074721_ChIP-Seq_CACO-2_Human1.15065957
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14296346
94RBPJ_21746931_ChIP-Seq_IB4_Human1.13854443
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13252653
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10994897
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.10862732
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09572604
99EZH2_27304074_Chip-Seq_ESCs_Mouse1.09431766
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09419784
101CBX2_22325352_ChIP-Seq_293T-Rex_Human1.08912556
102* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08552741
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08442119
104CDX2_22108803_ChIP-Seq_LS180_Human1.08286992
105* SMAD4_21741376_ChIP-Seq_EPCs_Human1.07677940
106CDX2_20551321_ChIP-Seq_CACO-2_Human1.06444733
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.06017678
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05533557
109SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05514548
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.04225406
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03969930
112P300_19829295_ChIP-Seq_ESCs_Human1.03911311
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03867524
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03729317
115ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03516116
116NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.03377960
117PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03255846
118RUNX2_22187159_ChIP-Seq_PCA_Human1.02965114
119TAF15_26573619_Chip-Seq_HEK293_Human1.02537679
120TAF2_19829295_ChIP-Seq_ESCs_Human1.02521827
121OCT1_27270436_Chip-Seq_PROSTATE_Human1.02104093
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02012188
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01185273
124STAT1_20625510_ChIP-Seq_HELA_Human1.00855731
125CJUN_26792858_Chip-Seq_BT549_Human1.00367417
126TCF4_23295773_ChIP-Seq_U87_Human1.00117928
127AR_25329375_ChIP-Seq_VCAP_Human0.99847910
128EGR1_19032775_ChIP-ChIP_M12_Human0.99793872
129FOXA2_19822575_ChIP-Seq_HepG2_Human0.99605418
130RXR_22108803_ChIP-Seq_LS180_Human0.98878860
131CBP_21632823_ChIP-Seq_H3396_Human0.98584239
132* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98219424
133DPY_21335234_ChIP-Seq_ESCs_Mouse0.98145257
134MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97680753
135SMAD4_21741376_ChIP-Seq_ESCs_Human0.97504770
136* PRDM14_20953172_ChIP-Seq_ESCs_Human0.97047510
137WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96377667
138CBP_20019798_ChIP-Seq_JUKART_Human0.95929757
139IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95929757
140AHR_22903824_ChIP-Seq_MCF-7_Human0.95864689
141CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95686682
142CEBPB_22108803_ChIP-Seq_LS180_Human0.95589301
143* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95579369
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95484988
145NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95484988
146JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95363222
147RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95267517
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94966777
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.94805485
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94656578
151RING1B_27294783_Chip-Seq_ESCs_Mouse0.94571599
152P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94092074
153PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93717610
154EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92763090
155GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92297946
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92261776
157FUS_26573619_Chip-Seq_HEK293_Human0.92255044
158TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.92088116
159ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91400997
160CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91243031
161ARNT_22903824_ChIP-Seq_MCF-7_Human0.88409053
162ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88372771
163OCT4_19829295_ChIP-Seq_ESCs_Human0.87707909
164KDM2B_26808549_Chip-Seq_DND41_Human0.87259264
165TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87050189
166GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86769056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.46560513
2MP0006072_abnormal_retinal_apoptosis6.66890911
3* MP0005253_abnormal_eye_physiology6.59587981
4MP0008875_abnormal_xenobiotic_pharmacok5.69852904
5MP0005623_abnormal_meninges_morphology4.58142400
6MP0002132_abnormal_respiratory_system4.31020862
7* MP0005195_abnormal_posterior_eye3.95521321
8MP0003950_abnormal_plasma_membrane3.78007304
9MP0001324_abnormal_eye_pigmentation3.75687960
10MP0000383_abnormal_hair_follicle3.27206453
11* MP0005391_vision/eye_phenotype3.25566090
12MP0005377_hearing/vestibular/ear_phenot2.92322657
13MP0003878_abnormal_ear_physiology2.92322657
14MP0002090_abnormal_vision2.88702767
15MP0002638_abnormal_pupillary_reflex2.83826969
16MP0010678_abnormal_skin_adnexa2.73157112
17MP0002277_abnormal_respiratory_mucosa2.70359374
18* MP0002229_neurodegeneration2.60180461
19MP0005083_abnormal_biliary_tract2.54386256
20MP0004133_heterotaxia2.41663826
21MP0002282_abnormal_trachea_morphology2.25775815
22MP0005423_abnormal_somatic_nervous2.23205683
23MP0002168_other_aberrant_phenotype2.17203469
24MP0002160_abnormal_reproductive_system2.05760514
25MP0002752_abnormal_somatic_nervous2.00942144
26MP0003011_delayed_dark_adaptation11.0912393
27MP0001764_abnormal_homeostasis1.92444407
28MP0002653_abnormal_ependyma_morphology1.85156449
29MP0001502_abnormal_circadian_rhythm1.50979193
30MP0000566_synostosis1.46943482
31MP0002882_abnormal_neuron_morphology1.46003388
32MP0003656_abnormal_erythrocyte_physiolo1.44053675
33MP0001765_abnormal_ion_homeostasis1.38829912
34MP0001986_abnormal_taste_sensitivity1.34166467
35MP0004019_abnormal_vitamin_homeostasis1.33887534
36MP0003195_calcinosis1.33352729
37MP0000678_abnormal_parathyroid_gland1.33105199
38MP0005395_other_phenotype1.32877360
39MP0004885_abnormal_endolymph1.27003570
40MP0002822_catalepsy1.23901677
41MP0004233_abnormal_muscle_weight1.13947961
42MP0006292_abnormal_olfactory_placode1.13051745
43MP0005085_abnormal_gallbladder_physiolo1.08632912
44MP0005197_abnormal_uvea_morphology1.02839532
45MP0005165_increased_susceptibility_to1.00832719
46MP0004270_analgesia1.00414944
47MP0001984_abnormal_olfaction1.00053677
48MP0009643_abnormal_urine_homeostasis0.99824807
49MP0005394_taste/olfaction_phenotype0.98665703
50MP0005499_abnormal_olfactory_system0.98665703
51MP0005503_abnormal_tendon_morphology0.94690718
52MP0008995_early_reproductive_senescence0.93955167
53MP0005389_reproductive_system_phenotype0.93799984
54MP0002909_abnormal_adrenal_gland0.93621417
55MP0005220_abnormal_exocrine_pancreas0.91953504
56MP0003698_abnormal_male_reproductive0.89629402
57MP0001929_abnormal_gametogenesis0.89185079
58MP0003634_abnormal_glial_cell0.87389736
59MP0010234_abnormal_vibrissa_follicle0.87008767
60MP0005636_abnormal_mineral_homeostasis0.86982063
61MP0002136_abnormal_kidney_physiology0.86906938
62MP0001485_abnormal_pinna_reflex0.86788041
63MP0008789_abnormal_olfactory_epithelium0.85793674
64MP0001486_abnormal_startle_reflex0.85607563
65MP0005187_abnormal_penis_morphology0.83621419
66MP0002127_abnormal_cardiovascular_syste0.83213726
67MP0005164_abnormal_response_to0.79898660
68MP0002332_abnormal_exercise_endurance0.77079877
69MP0005310_abnormal_salivary_gland0.75968303
70MP0008057_abnormal_DNA_replication0.75931991
71MP0002876_abnormal_thyroid_physiology0.73938367
72MP0002233_abnormal_nose_morphology0.73210165
73MP0005248_abnormal_Harderian_gland0.73175792
74MP0003880_abnormal_central_pattern0.71985263
75MP0002272_abnormal_nervous_system0.70453418
76MP0004859_abnormal_synaptic_plasticity0.68158638
77MP0002249_abnormal_larynx_morphology0.67090272
78MP0005388_respiratory_system_phenotype0.66340114
79MP0002133_abnormal_respiratory_system0.66340114
80MP0002405_respiratory_system_inflammati0.66154456
81MP0005647_abnormal_sex_gland0.65358399
82MP0001286_abnormal_eye_development0.64491732
83MP0001851_eye_inflammation0.64424493
84MP0000427_abnormal_hair_cycle0.63718953
85MP0001664_abnormal_digestion0.63599311
86MP0009765_abnormal_xenobiotic_induced0.61536712
87MP0002135_abnormal_kidney_morphology0.61319985
88MP0010155_abnormal_intestine_physiology0.58898488
89MP0002735_abnormal_chemical_nociception0.58623018
90MP0003635_abnormal_synaptic_transmissio0.58164572
91MP0001299_abnormal_eye_distance/0.57832178
92MP0003453_abnormal_keratinocyte_physiol0.57639513
93MP0002064_seizures0.57141869
94MP0002734_abnormal_mechanical_nocicepti0.54587383
95MP0000681_abnormal_thyroid_gland0.52166156
96MP0001944_abnormal_pancreas_morphology0.52070501
97MP0009046_muscle_twitch0.51908840
98MP0001963_abnormal_hearing_physiology0.50278389
99MP0005646_abnormal_pituitary_gland0.49985230
100MP0003937_abnormal_limbs/digits/tail_de0.49319100
101MP0002697_abnormal_eye_size0.48973486
102MP0004215_abnormal_myocardial_fiber0.47597679
103MP0001666_abnormal_nutrient_absorption0.47189815
104MP0002063_abnormal_learning/memory/cond0.45182313
105MP0005365_abnormal_bile_salt0.45076279
106MP0003890_abnormal_embryonic-extraembry0.45063051
107MP0002116_abnormal_craniofacial_bone0.43997880
108MP0006082_CNS_inflammation0.43585563
109MP0000465_gastrointestinal_hemorrhage0.42566393
110MP0002067_abnormal_sensory_capabilities0.41978661
111MP0005376_homeostasis/metabolism_phenot0.40132504
112MP0005386_behavior/neurological_phenoty0.39172976
113MP0004924_abnormal_behavior0.39172976
114MP0004782_abnormal_surfactant_physiolog0.38450845
115MP0004145_abnormal_muscle_electrophysio0.35830368
116MP0002572_abnormal_emotion/affect_behav0.34945483
117MP0003045_fibrosis0.34293932
118MP0000631_abnormal_neuroendocrine_gland0.34191566
119MP0009780_abnormal_chondrocyte_physiolo0.33891749
120MP0009745_abnormal_behavioral_response0.33448967
121MP0010030_abnormal_orbit_morphology0.33382747
122MP0005193_abnormal_anterior_eye0.33367417
123MP0004742_abnormal_vestibular_system0.31223015
124MP0004085_abnormal_heartbeat0.30999213
125MP0001968_abnormal_touch/_nociception0.30533432
126MP0002184_abnormal_innervation0.29919672
127MP0002152_abnormal_brain_morphology0.29660121
128MP0010386_abnormal_urinary_bladder0.29059642
129MP0005620_abnormal_muscle_contractility0.28816712
130MP0000778_abnormal_nervous_system0.27700157
131MP0004043_abnormal_pH_regulation0.27538589
132MP0003632_abnormal_nervous_system0.25937592
133MP0003633_abnormal_nervous_system0.25867199
134MP0008569_lethality_at_weaning0.25693472
135MP0004811_abnormal_neuron_physiology0.25374883
136MP0005076_abnormal_cell_differentiation0.25134864
137MP0002066_abnormal_motor_capabilities/c0.24722799
138MP0008004_abnormal_stomach_pH0.24357901
139MP0002234_abnormal_pharynx_morphology0.24081345
140MP0001915_intracranial_hemorrhage0.23942996
141MP0002102_abnormal_ear_morphology0.23857578
142MP0000026_abnormal_inner_ear0.23477046
143MP0000751_myopathy0.22427468
144MP0001293_anophthalmia0.21607805
145MP0005595_abnormal_vascular_smooth0.21183988
146MP0001346_abnormal_lacrimal_gland0.20659369
147MP0003631_nervous_system_phenotype0.19811490
148MP0004036_abnormal_muscle_relaxation0.19458242
149MP0001177_atelectasis0.17851831
150MP0002092_abnormal_eye_morphology0.17811819
151MP0004142_abnormal_muscle_tone0.15923837
152MP0008961_abnormal_basal_metabolism0.15878510
153MP0000955_abnormal_spinal_cord0.15734328
154MP0001879_abnormal_lymphatic_vessel0.15694737
155MP0003943_abnormal_hepatobiliary_system0.15183399
156MP0002928_abnormal_bile_duct0.14777362
157MP0002108_abnormal_muscle_morphology0.14729373
158MP0001661_extended_life_span0.14576733
159MP0004084_abnormal_cardiac_muscle0.14550999
160MP0010368_abnormal_lymphatic_system0.14060080
161MP0002557_abnormal_social/conspecific_i0.13498869

Predicted human phenotypes

RankGene SetZ-score
1Chorioretinal atrophy (HP:0000533)9.57218714
2* Absent rod-and cone-mediated responses on ERG (HP:0007688)9.34937022
3* Abnormal rod and cone electroretinograms (HP:0008323)9.26359837
4Rhinitis (HP:0012384)9.21823834
5Pigmentary retinal degeneration (HP:0001146)9.07990017
6Central scotoma (HP:0000603)9.03060092
7Pendular nystagmus (HP:0012043)8.81392240
8Scotoma (HP:0000575)8.10617734
9Abolished electroretinogram (ERG) (HP:0000550)8.10076011
10Abnormality of macular pigmentation (HP:0008002)7.78315038
11Dyschromatopsia (HP:0007641)7.77682242
12Chronic bronchitis (HP:0004469)7.52062223
13Attenuation of retinal blood vessels (HP:0007843)7.34204078
14Bronchiectasis (HP:0002110)7.00856526
15Decreased central vision (HP:0007663)6.64333330
16Nasal polyposis (HP:0100582)6.33790222
17Posterior subcapsular cataract (HP:0007787)5.81505377
18Severe visual impairment (HP:0001141)5.64896850
19Cone-rod dystrophy (HP:0000548)5.61201469
20Increased corneal curvature (HP:0100692)5.59700847
21Keratoconus (HP:0000563)5.59700847
22Macular degeneration (HP:0000608)5.56277726
23* Type II diabetes mellitus (HP:0005978)5.55145315
24* Photophobia (HP:0000613)5.42354322
25Vitreoretinal degeneration (HP:0000655)5.41061548
26Abnormality of the nasal mucosa (HP:0000433)5.29431714
27Bronchitis (HP:0012387)4.64384912
28Choroideremia (HP:0001139)4.24004560
29* Retinitis pigmentosa (HP:0000510)4.06668969
30Chronic sinusitis (HP:0011109)3.82271629
31Recurrent otitis media (HP:0000403)3.77711613
32Decreased electroretinogram (ERG) amplitude (HP:0000654)3.72991003
33Infertility (HP:0000789)3.69881920
34Tubulointerstitial nephritis (HP:0001970)3.64849757
35Subcapsular cataract (HP:0000523)3.57132143
36Progressive visual loss (HP:0000529)3.46116316
37* Constricted visual fields (HP:0001133)3.36412379
38Occipital encephalocele (HP:0002085)3.14803354
39Male infertility (HP:0003251)3.03905002
40Retinal atrophy (HP:0001105)3.03220375
41Hyperactive renin-angiotensin system (HP:0000841)2.93672637
42Congenital sensorineural hearing impairment (HP:0008527)2.75734192
43Nephronophthisis (HP:0000090)2.75070146
44Recurrent bronchitis (HP:0002837)2.66606761
45Chronic otitis media (HP:0000389)2.54711817
46* Wide nasal bridge (HP:0000431)2.46247712
47Atelectasis (HP:0100750)2.37561234
48Optic disc pallor (HP:0000543)2.31478524
49Gait imbalance (HP:0002141)2.30963211
50Congenital primary aphakia (HP:0007707)2.28189051
51Abnormality of the renal medulla (HP:0100957)2.27739516
52Decreased circulating renin level (HP:0003351)2.18315084
53Bell-shaped thorax (HP:0001591)2.05082506
54Nephrogenic diabetes insipidus (HP:0009806)2.01359921
55Congenital stationary night blindness (HP:0007642)13.1082773
56Dynein arm defect of respiratory motile cilia (HP:0012255)12.3526134
57Absent/shortened dynein arms (HP:0200106)12.3526134
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.9960942
59Abnormal ciliary motility (HP:0012262)11.0470139
60Abnormal respiratory epithelium morphology (HP:0012253)10.8393460
61Abnormal respiratory motile cilium morphology (HP:0005938)10.8393460
62Abnormal respiratory motile cilium physiology (HP:0012261)10.7384667
63* Bony spicule pigmentary retinopathy (HP:0007737)10.6409415
64Polar cataract (HP:0010696)1.98021941
65Medial flaring of the eyebrow (HP:0010747)1.92482612
66Tubulointerstitial abnormality (HP:0001969)1.89555707
67Hyperkalemia (HP:0002153)1.86762654
68Renal salt wasting (HP:0000127)1.75364508
69Poor coordination (HP:0002370)1.75019426
70Horizontal nystagmus (HP:0000666)1.71850130
71True hermaphroditism (HP:0010459)1.69513508
72Pancreatic fibrosis (HP:0100732)1.68734860
73Tubular atrophy (HP:0000092)1.66802094
74Interstitial pulmonary disease (HP:0006530)1.64073963
75Male pseudohermaphroditism (HP:0000037)1.61317220
76Vaginal atresia (HP:0000148)1.57436180
77* Optic atrophy (HP:0000648)1.56434778
78Supernumerary spleens (HP:0009799)1.55325155
79Severe Myopia (HP:0011003)1.53332548
80Hyperaldosteronism (HP:0000859)1.52528410
81Genital tract atresia (HP:0001827)1.51001048
82Absent frontal sinuses (HP:0002688)1.50071930
83Nephropathy (HP:0000112)1.46347480
84Asplenia (HP:0001746)1.43385561
85Aplasia/Hypoplasia of the spleen (HP:0010451)1.41956476
86Cystic liver disease (HP:0006706)1.41565526
87Abnormality of renin-angiotensin system (HP:0000847)1.40780232
88Oculomotor apraxia (HP:0000657)1.39335809
89Aplasia/Hypoplasia of the lens (HP:0008063)1.36389248
90Abnormality of chloride homeostasis (HP:0011422)1.35845543
91Pancreatic cysts (HP:0001737)1.35651010
92Portal hypertension (HP:0001409)1.32315853
93Hypokalemic alkalosis (HP:0001949)1.30938575
94Dysdiadochokinesis (HP:0002075)1.30814219
95Progressive sensorineural hearing impairment (HP:0000408)1.30422820
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.29080589
97Median cleft lip (HP:0000161)1.26382702
98Menstrual irregularities (HP:0000858)1.26211920
99Stage 5 chronic kidney disease (HP:0003774)1.25321742
100Abnormality of the fovea (HP:0000493)1.24266851
101Sclerocornea (HP:0000647)1.23671765
102Abnormality of the hepatic vasculature (HP:0006707)1.19053575
103Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.18632204
104Preaxial hand polydactyly (HP:0001177)1.18147683
105Abnormality of the dental pulp (HP:0006479)1.18114978
106Abnormality of the dental root (HP:0006486)1.16900496
107Taurodontia (HP:0000679)1.16900496
108Abnormality of permanent molar morphology (HP:0011071)1.16900496
109Short nail (HP:0001799)1.15928316
110Hypoplasia of the fovea (HP:0007750)1.15708849
111Aplasia/Hypoplasia of the fovea (HP:0008060)1.15708849
112Short thorax (HP:0010306)1.14843019
113Epileptic encephalopathy (HP:0200134)1.14024293
114Retinal detachment (HP:0000541)1.13825549
115Abnormality of the renal cortex (HP:0011035)1.11135843
116Lip pit (HP:0100267)1.09926120
117Tubulointerstitial fibrosis (HP:0005576)1.09010271
118Astigmatism (HP:0000483)1.08846027
119Bifid scrotum (HP:0000048)1.08421829
120Recurrent pneumonia (HP:0006532)1.08352327
121Abnormality of molar morphology (HP:0011070)1.07381099
122Abnormality of molar (HP:0011077)1.07381099
123Glucose intolerance (HP:0000833)1.06547070
124Furrowed tongue (HP:0000221)1.03711594
125Chorioretinal coloboma (HP:0000567)1.03687949
126Febrile seizures (HP:0002373)1.03174753
127Visual hallucinations (HP:0002367)1.03112846
128Renovascular hypertension (HP:0100817)0.99275021
129Aplasia/Hypoplasia of the macula (HP:0008059)0.98907378
130Recurrent sinusitis (HP:0011108)0.98830039
131Hyponatremia (HP:0002902)0.98265488
132Truncal ataxia (HP:0002078)0.98172245
133Facial cleft (HP:0002006)0.98056087
134Abnormality of dentin (HP:0010299)0.97314843
135Hypermetropia (HP:0000540)0.96197211
136Left ventricular hypertrophy (HP:0001712)0.93691050
137Specific learning disability (HP:0001328)0.93578411
138Aplasia/Hypoplasia affecting the retina (HP:0008061)0.93099007
139Progressive cerebellar ataxia (HP:0002073)0.92382162
140Broad foot (HP:0001769)0.89487113
141Abnormality of the lower motor neuron (HP:0002366)0.87839726
142Genetic anticipation (HP:0003743)0.86640201
143Asthma (HP:0002099)0.86378148
144Anencephaly (HP:0002323)0.86352790
145Decreased testicular size (HP:0008734)0.84364437
146Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.83051968
147Molar tooth sign on MRI (HP:0002419)0.79558834
148Abnormality of midbrain morphology (HP:0002418)0.79558834
149Prolonged QT interval (HP:0001657)0.78556447
150Congenital hepatic fibrosis (HP:0002612)0.77396087
151Macroorchidism (HP:0000053)0.73800017
152Abnormality of the fingertips (HP:0001211)0.73332221
153Postaxial hand polydactyly (HP:0001162)0.69926254
154Postaxial foot polydactyly (HP:0001830)0.68502309
155Cerebellar dysplasia (HP:0007033)0.66171574
156Hypodontia (HP:0000668)0.64969085
157Supranuclear gaze palsy (HP:0000605)0.64377015
158Hypoventilation (HP:0002791)0.64237277
159Anophthalmia (HP:0000528)0.64229402
160Abnormality of dental color (HP:0011073)0.64027195
161Dental crowding (HP:0000678)0.63011968
162Aqueductal stenosis (HP:0002410)0.62898760
163Depression (HP:0000716)0.62290470
164Short foot (HP:0001773)0.61542493
165Postural instability (HP:0002172)0.61110622
166Chronic hepatic failure (HP:0100626)0.60663138
167Abnormal EKG (HP:0003115)0.59451524
168Intention tremor (HP:0002080)0.58539706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.89623131
2PBK4.84416177
3EPHA23.94471462
4PINK13.51819060
5MAP3K102.98938752
6IRAK22.90001483
7BCR2.43294975
8MAP3K22.18546507
9MST1R2.13263959
10GRK110.8623629
11MAPK1510.0427685
12CAMK1G1.82545289
13NME11.80682054
14STK161.79707306
15SIK21.75155861
16PTK2B1.74315348
17MAPKAPK31.53893848
18SGK2231.51526228
19SGK4941.51526228
20CAMK1D1.48155376
21HIPK21.47235503
22PNCK1.46591841
23EEF2K1.40531927
24CDK121.36887710
25ADRBK11.36586892
26PRKD31.36013416
27ERBB21.35529291
28MARK11.35445148
29STK241.31587342
30MAP3K31.30636721
31TRPM71.29148312
32STK38L1.28182749
33PAK61.27760166
34BRD41.27621798
35ICK1.26703666
36TLK11.25383139
37MAPK121.25227088
38IRAK11.24512519
39MAP3K41.24438062
40MAPK71.23180367
41CSK1.22664234
42STK101.21006632
43NEK11.18083009
44MET1.13734993
45TYK21.13167284
46CSNK1D1.13060915
47STK381.12580851
48PRKCH1.11784582
49MARK21.11395549
50SGK21.05259229
51TAOK31.00429907
52INSRR0.99924784
53SGK30.98208234
54CAMKK10.97593712
55SCYL20.91950811
56LRRK20.88433628
57RPS6KA40.88307469
58DYRK1B0.88222641
59BRSK20.88137994
60NEK60.86956844
61PRKCI0.85247923
62WNK10.83622747
63PRKCZ0.82866899
64DYRK1A0.78563352
65LATS10.77960938
66PRKAA10.77552926
67PRKCB0.76192745
68FER0.76099294
69EPHB10.76013612
70AKT30.71929301
71MUSK0.71276229
72CAMK2D0.67722750
73RPS6KA30.66745136
74SGK10.63987450
75SIK10.62995154
76GRK50.62105469
77OXSR10.61252394
78EPHA30.61030806
79PRKACG0.60527773
80PIK3CA0.59790829
81PLK20.58623913
82FRK0.57723274
83PRKAA20.57451705
84CDK90.57377049
85SMG10.54753102
86PRKD20.54706851
87GSK3B0.54547003
88CDK50.54422388
89MINK10.54184610
90CDK30.53557582
91NEK20.52689453
92MAPK100.52329017
93RPS6KA20.51864663
94FES0.51483379
95MAPK140.51121143
96STK110.50786045
97MAPK90.50743795
98PLK30.50233798
99PRKCQ0.48591125
100PRKDC0.48559828
101EGFR0.47120433
102ERBB30.47014885
103TBK10.46481660
104CAMK40.45967830
105CDK10.45128668
106CAMK10.44778386
107STK30.44436460
108PHKG20.42845084
109PHKG10.42845084
110MAP2K70.42830033
111NLK0.42651520
112MAP3K70.39832625
113AURKA0.39618433
114CDC42BPA0.39577331
115NTRK20.39553051
116CAMK2A0.38789427
117STK390.38675376
118LMTK20.38469282
119NEK90.38404647
120ZAP700.38329267
121ADRBK20.37185584
122ALK0.37143236
123PTK60.36806105
124AKT20.35812614
125PRKD10.35488805
126MAP2K40.35461437
127BMPR1B0.34543873
128PKN10.34208872
129CSNK1E0.33991340
130PAK30.32522778
131RET0.31636923
132RIPK10.31575015
133PRKACA0.31434776
134ACVR1B0.31287071
135BLK0.30811214
136MAPK80.30726964
137RPS6KB20.30160780
138WNK40.29849388
139CSNK1G20.29630157
140ATM0.29606256
141CHUK0.29312945
142FGFR20.28992050
143PRKCG0.28633178
144CSNK1A1L0.28183156
145ROCK10.27813116
146PDPK10.27596168
147CAMK2G0.27342901
148FYN0.27274108
149PRKCD0.27096810
150TAOK10.26941136
151PDGFRB0.26703348
152ABL10.26424392
153MYLK0.25633525
154RPS6KB10.25398744
155PRKCE0.24975353
156PRKCA0.24763184
157TTK0.24514026
158CHEK10.22722771
159TEC0.21834856
160ERBB40.21765125
161SRC0.21664791
162TGFBR10.21630851
163MELK0.18545269
164RPS6KA60.17537168
165IGF1R0.16510238
166CDK60.16154330

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.69257303
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.10471910
3Chemical carcinogenesis_Homo sapiens_hsa052044.02441237
4Histidine metabolism_Homo sapiens_hsa003403.89384898
5Phenylalanine metabolism_Homo sapiens_hsa003603.62080536
6Tyrosine metabolism_Homo sapiens_hsa003502.89824751
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.66715611
8beta-Alanine metabolism_Homo sapiens_hsa004102.64118737
9Huntingtons disease_Homo sapiens_hsa050162.51532811
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.11755999
11Linoleic acid metabolism_Homo sapiens_hsa005912.09607481
12Phototransduction_Homo sapiens_hsa0474415.5500425
13Sphingolipid metabolism_Homo sapiens_hsa006001.94788732
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.87023176
15Synaptic vesicle cycle_Homo sapiens_hsa047211.80910084
16Glutathione metabolism_Homo sapiens_hsa004801.77087958
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.69010828
18Olfactory transduction_Homo sapiens_hsa047401.61145625
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.44443212
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36684237
21GABAergic synapse_Homo sapiens_hsa047271.35606074
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18736768
23Nitrogen metabolism_Homo sapiens_hsa009101.11673605
24Arachidonic acid metabolism_Homo sapiens_hsa005901.06819926
25Taste transduction_Homo sapiens_hsa047421.03060236
26Fatty acid degradation_Homo sapiens_hsa000711.02040840
27Cholinergic synapse_Homo sapiens_hsa047251.00489627
28Circadian rhythm_Homo sapiens_hsa047100.96856876
29Tryptophan metabolism_Homo sapiens_hsa003800.93327803
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92881872
31Circadian entrainment_Homo sapiens_hsa047130.92219164
32Adherens junction_Homo sapiens_hsa045200.92028139
33Starch and sucrose metabolism_Homo sapiens_hsa005000.91342897
34Retinol metabolism_Homo sapiens_hsa008300.89809303
35Morphine addiction_Homo sapiens_hsa050320.89180323
36Glutamatergic synapse_Homo sapiens_hsa047240.89018975
37Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86242791
38Dopaminergic synapse_Homo sapiens_hsa047280.84298099
39Peroxisome_Homo sapiens_hsa041460.83453500
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76893583
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74472712
42Hematopoietic cell lineage_Homo sapiens_hsa046400.71517422
43ABC transporters_Homo sapiens_hsa020100.71427562
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71135021
45Leukocyte transendothelial migration_Homo sapiens_hsa046700.70014601
46Complement and coagulation cascades_Homo sapiens_hsa046100.69184366
47Notch signaling pathway_Homo sapiens_hsa043300.68777817
48Hepatitis C_Homo sapiens_hsa051600.68313069
49Insulin secretion_Homo sapiens_hsa049110.66445381
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63753871
51Serotonergic synapse_Homo sapiens_hsa047260.62411769
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61352883
53Nicotine addiction_Homo sapiens_hsa050330.58490755
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.55033919
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52536621
56Oxytocin signaling pathway_Homo sapiens_hsa049210.52394725
57ECM-receptor interaction_Homo sapiens_hsa045120.51693030
58Hedgehog signaling pathway_Homo sapiens_hsa043400.50782519
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49697238
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49453131
61Ovarian steroidogenesis_Homo sapiens_hsa049130.49433724
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47694681
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47326262
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46285276
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46249256
66Amoebiasis_Homo sapiens_hsa051460.45106826
67mTOR signaling pathway_Homo sapiens_hsa041500.44954029
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44935874
69Dorso-ventral axis formation_Homo sapiens_hsa043200.42964331
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42559656
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42259386
72Renin secretion_Homo sapiens_hsa049240.41495513
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41339913
74Salivary secretion_Homo sapiens_hsa049700.41102313
75cAMP signaling pathway_Homo sapiens_hsa040240.41093834
76Dilated cardiomyopathy_Homo sapiens_hsa054140.41050287
77Inositol phosphate metabolism_Homo sapiens_hsa005620.39174242
78PPAR signaling pathway_Homo sapiens_hsa033200.38004443
79Vitamin digestion and absorption_Homo sapiens_hsa049770.37575368
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37506452
81Gastric acid secretion_Homo sapiens_hsa049710.36131591
82Lysine degradation_Homo sapiens_hsa003100.35674093
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.35176843
84Glycerolipid metabolism_Homo sapiens_hsa005610.35084064
85Cardiac muscle contraction_Homo sapiens_hsa042600.34951458
86Basal cell carcinoma_Homo sapiens_hsa052170.34412707
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33686986
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33369942
89Fructose and mannose metabolism_Homo sapiens_hsa000510.33171249
90Long-term potentiation_Homo sapiens_hsa047200.32888412
91Purine metabolism_Homo sapiens_hsa002300.30514497
92Cocaine addiction_Homo sapiens_hsa050300.29933711
93Butanoate metabolism_Homo sapiens_hsa006500.29892870
94Type II diabetes mellitus_Homo sapiens_hsa049300.29281668
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29171523
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.28616038
97Glucagon signaling pathway_Homo sapiens_hsa049220.28564784
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.27234172
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27170152
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26802052
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.26670605
102Amphetamine addiction_Homo sapiens_hsa050310.26327333
103Arginine biosynthesis_Homo sapiens_hsa002200.26219694
104Caffeine metabolism_Homo sapiens_hsa002320.25729140
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24925932
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24851752
107Alcoholism_Homo sapiens_hsa050340.24825622
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23737130
109Bile secretion_Homo sapiens_hsa049760.23563777
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23358147
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23322818
112Fatty acid elongation_Homo sapiens_hsa000620.23184740
113HIF-1 signaling pathway_Homo sapiens_hsa040660.23014627
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.21878743
115AMPK signaling pathway_Homo sapiens_hsa041520.21726649
116Tight junction_Homo sapiens_hsa045300.21317597
117Prostate cancer_Homo sapiens_hsa052150.20594573
118Small cell lung cancer_Homo sapiens_hsa052220.19929619
119Arginine and proline metabolism_Homo sapiens_hsa003300.19861841
120Chemokine signaling pathway_Homo sapiens_hsa040620.19145123
121GnRH signaling pathway_Homo sapiens_hsa049120.17665247
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.17627313
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.17423202
124Glioma_Homo sapiens_hsa052140.16695924
125Thyroid hormone synthesis_Homo sapiens_hsa049180.16626501
126Fatty acid biosynthesis_Homo sapiens_hsa000610.16191549
127Axon guidance_Homo sapiens_hsa043600.15665431
128Ras signaling pathway_Homo sapiens_hsa040140.15394107
129Asthma_Homo sapiens_hsa053100.15306864
130Calcium signaling pathway_Homo sapiens_hsa040200.15282834
131Pancreatic secretion_Homo sapiens_hsa049720.14931971
132mRNA surveillance pathway_Homo sapiens_hsa030150.13763716
133Renal cell carcinoma_Homo sapiens_hsa052110.13662958
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.13525101
135Biosynthesis of amino acids_Homo sapiens_hsa012300.12963638
136Insulin resistance_Homo sapiens_hsa049310.12714497
137MAPK signaling pathway_Homo sapiens_hsa040100.12313776
138Choline metabolism in cancer_Homo sapiens_hsa052310.12186624
139Metabolic pathways_Homo sapiens_hsa011000.12175814
140Mineral absorption_Homo sapiens_hsa049780.11838355
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.11335915
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11096288
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.10670897
144Hippo signaling pathway_Homo sapiens_hsa043900.10378869
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.09653480
146Endometrial cancer_Homo sapiens_hsa052130.09237554
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.08763375
148Galactose metabolism_Homo sapiens_hsa000520.07507304
149Wnt signaling pathway_Homo sapiens_hsa043100.07495848
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.07121259
151ErbB signaling pathway_Homo sapiens_hsa040120.06803083
152Melanogenesis_Homo sapiens_hsa049160.06705515
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.05784943
154Endocytosis_Homo sapiens_hsa041440.05510774
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05438041
156Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.05302000
157Collecting duct acid secretion_Homo sapiens_hsa049660.05066331
158Non-small cell lung cancer_Homo sapiens_hsa052230.04537802

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »