RP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene can be bound and phosphorylated by the protooncogene PIM1 product, a serine/threonine protein kinase . This protein localizes in nuclear speckles containing the splicing factors, and has a role in pre-mRNA splicing. CBF1-interacting protein (CIR), a corepressor of CBF1, can also bind to this protein and effects alternative splicing. Mutations in this gene result in autosomal dominant retinitis pigmentosa-9. This gene has a pseudogene (GeneID: 441212), which is located in tandem array approximately 166 kb distal to this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.69819050
2viral transcription (GO:0019083)8.55210036
3translational termination (GO:0006415)8.16119833
4ribosomal small subunit biogenesis (GO:0042274)7.56062239
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.14134107
6translational elongation (GO:0006414)7.03903995
7protein targeting to ER (GO:0045047)6.99030804
8cotranslational protein targeting to membrane (GO:0006613)6.98956174
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.67018089
10protein localization to endoplasmic reticulum (GO:0070972)6.60926395
11maturation of SSU-rRNA (GO:0030490)6.58616499
12viral life cycle (GO:0019058)6.35473317
13cellular protein complex disassembly (GO:0043624)6.27171910
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.16882714
15DNA deamination (GO:0045006)6.14523673
16translational initiation (GO:0006413)5.92233283
17chaperone-mediated protein transport (GO:0072321)5.63366071
18protein complex disassembly (GO:0043241)5.50524828
19ribosomal large subunit biogenesis (GO:0042273)5.38327649
20macromolecular complex disassembly (GO:0032984)5.17303586
21establishment of protein localization to mitochondrial membrane (GO:0090151)5.08471154
22protein targeting to membrane (GO:0006612)4.57668594
23translation (GO:0006412)4.53748452
24nuclear-transcribed mRNA catabolic process (GO:0000956)4.46843047
25mRNA catabolic process (GO:0006402)4.25443223
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.01871747
27ribonucleoprotein complex biogenesis (GO:0022613)3.99574120
28RNA catabolic process (GO:0006401)3.99138526
29telomere maintenance via semi-conservative replication (GO:0032201)3.87470753
30protein neddylation (GO:0045116)3.70938815
31DNA strand elongation involved in DNA replication (GO:0006271)3.69870864
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58597864
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.58597864
34DNA strand elongation (GO:0022616)3.54907434
35behavioral response to nicotine (GO:0035095)3.53952743
36establishment of protein localization to mitochondrion (GO:0072655)3.51919102
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50538490
38base-excision repair, AP site formation (GO:0006285)3.42856963
39DNA damage response, detection of DNA damage (GO:0042769)3.40840256
40cellular component biogenesis (GO:0044085)3.38066334
41protein localization to mitochondrion (GO:0070585)3.37741384
42UTP metabolic process (GO:0046051)3.32304737
43respiratory chain complex IV assembly (GO:0008535)3.27353505
44rRNA processing (GO:0006364)3.27316584
45pseudouridine synthesis (GO:0001522)3.26671598
46ATP synthesis coupled proton transport (GO:0015986)3.20041973
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20041973
48rRNA metabolic process (GO:0016072)3.16820924
49telomere maintenance via recombination (GO:0000722)3.15947116
50guanosine-containing compound biosynthetic process (GO:1901070)3.13584045
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13240938
52establishment of protein localization to membrane (GO:0090150)3.12604965
53formation of translation preinitiation complex (GO:0001731)3.12524226
54heme biosynthetic process (GO:0006783)3.11913367
55protein targeting (GO:0006605)3.04220654
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.03524421
57termination of RNA polymerase III transcription (GO:0006386)3.03272161
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.03272161
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02972762
60negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.02348077
61ncRNA 3-end processing (GO:0043628)3.01967570
62substrate-independent telencephalic tangential migration (GO:0021826)2.99842153
63substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.99842153
64antigen processing and presentation of endogenous antigen (GO:0019883)2.99795887
65inner mitochondrial membrane organization (GO:0007007)2.96505075
66cullin deneddylation (GO:0010388)2.95588870
67establishment of protein localization to organelle (GO:0072594)2.93990343
68spliceosomal snRNP assembly (GO:0000387)2.90949071
69tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90834368
70RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90834368
71sequestering of actin monomers (GO:0042989)2.90091057
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89739747
73DNA replication initiation (GO:0006270)2.89427473
74deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.86072720
75hydrogen ion transmembrane transport (GO:1902600)2.84739841
76mitotic recombination (GO:0006312)2.84269975
77ubiquinone biosynthetic process (GO:0006744)2.82942185
78respiratory electron transport chain (GO:0022904)2.82656584
79nucleotide-excision repair, DNA gap filling (GO:0006297)2.82287971
80ribonucleoprotein complex disassembly (GO:0032988)2.80422383
81pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.80339195
82electron transport chain (GO:0022900)2.79610955
83oxidative phosphorylation (GO:0006119)2.78971021
84pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.78688527
85ribonucleoside triphosphate biosynthetic process (GO:0009201)2.77293780
86iron-sulfur cluster assembly (GO:0016226)2.76191498
87metallo-sulfur cluster assembly (GO:0031163)2.76191498
88protein deneddylation (GO:0000338)2.75912091
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75657553
90mitochondrial respiratory chain complex I assembly (GO:0032981)2.75657553
91NADH dehydrogenase complex assembly (GO:0010257)2.75657553
92DNA replication checkpoint (GO:0000076)2.74941718
93pyrimidine nucleotide catabolic process (GO:0006244)2.74929172
94mitochondrial respiratory chain complex assembly (GO:0033108)2.74739095
95organelle disassembly (GO:1903008)2.74371855
96proteasome assembly (GO:0043248)2.74349060
97pteridine-containing compound biosynthetic process (GO:0042559)2.73780286
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73717176
99cytochrome complex assembly (GO:0017004)2.73046893
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.72899621
101regulation of mitochondrial translation (GO:0070129)2.71474728
102ATP biosynthetic process (GO:0006754)2.71371524
103protein-cofactor linkage (GO:0018065)2.68886319
104mitochondrial transport (GO:0006839)2.67870032
105intracellular protein transmembrane import (GO:0044743)2.67672292
106DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.67413280
107DNA unwinding involved in DNA replication (GO:0006268)2.66323754
108telomere maintenance via telomere lengthening (GO:0010833)2.66295844
109protein complex biogenesis (GO:0070271)2.66228633
110mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65384135
111heme metabolic process (GO:0042168)2.63974413
112regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.62025074
113pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.61610162
114deoxyribonucleotide catabolic process (GO:0009264)2.58982722
115GTP biosynthetic process (GO:0006183)2.58023211
116spliceosomal complex assembly (GO:0000245)2.57893232
117viral mRNA export from host cell nucleus (GO:0046784)2.57208486
118establishment of integrated proviral latency (GO:0075713)2.56081400
119folic acid-containing compound biosynthetic process (GO:0009396)2.56001305
120CTP biosynthetic process (GO:0006241)2.55739510
121CTP metabolic process (GO:0046036)2.55739510
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55466970
123pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.48664775
124positive regulation of B cell differentiation (GO:0045579)2.46486335
125transcription-coupled nucleotide-excision repair (GO:0006283)2.45478425
126deoxyribose phosphate catabolic process (GO:0046386)2.44456493
127pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.44433923
128tRNA methylation (GO:0030488)2.44046791
129UTP biosynthetic process (GO:0006228)2.42398892
130histone mRNA metabolic process (GO:0008334)2.42201151
131negative regulation of erythrocyte differentiation (GO:0045647)2.41333778
132chromatin remodeling at centromere (GO:0031055)2.39383401
133protein targeting to mitochondrion (GO:0006626)2.38183781
134protein localization to membrane (GO:0072657)2.37399352
135pyrimidine nucleoside biosynthetic process (GO:0046134)2.37304458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.16542920
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.25093579
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.04312054
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.02179770
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.75606990
6EZH2_22144423_ChIP-Seq_EOC_Human3.01828304
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.92248225
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85651118
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.83962562
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.80191853
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.78806420
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74627632
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69241023
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56402926
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.54106768
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51371897
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42693752
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41464324
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.39826344
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.38968421
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31185630
22XRN2_22483619_ChIP-Seq_HELA_Human2.30938123
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23874106
24VDR_23849224_ChIP-Seq_CD4+_Human2.21825527
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.16514625
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12456812
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07129058
28FOXP3_21729870_ChIP-Seq_TREG_Human2.06105811
29DCP1A_22483619_ChIP-Seq_HELA_Human2.02336855
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91149984
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.87974904
32VDR_21846776_ChIP-Seq_THP-1_Human1.86510517
33SCL_19346495_ChIP-Seq_HPC-7_Human1.84034275
34ZNF274_21170338_ChIP-Seq_K562_Hela1.83098194
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79544738
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78995056
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78911199
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77679916
39ERG_20887958_ChIP-Seq_HPC-7_Mouse1.77057735
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76556193
41TTF2_22483619_ChIP-Seq_HELA_Human1.75707741
42MYC_22102868_ChIP-Seq_BL_Human1.71703548
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.70572918
44GABP_19822575_ChIP-Seq_HepG2_Human1.70456137
45IRF1_19129219_ChIP-ChIP_H3396_Human1.67755928
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.64291001
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63608946
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63192332
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.60336425
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59117783
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58839508
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.58805128
53CIITA_25753668_ChIP-Seq_RAJI_Human1.57024136
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56780938
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52550216
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51402447
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.49665302
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48709109
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45820661
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45461590
61SPI1_23547873_ChIP-Seq_NB4_Human1.44810923
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41454076
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.39861433
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36379651
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.35910464
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34160067
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33918086
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33697468
69* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33313196
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29302264
71EWS_26573619_Chip-Seq_HEK293_Human1.28576117
72ELK1_19687146_ChIP-ChIP_HELA_Human1.28150864
73TP53_22573176_ChIP-Seq_HFKS_Human1.27998584
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27319478
75IGF1R_20145208_ChIP-Seq_DFB_Human1.24501807
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23833354
77VDR_22108803_ChIP-Seq_LS180_Human1.22523192
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21520566
79SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21018432
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20896678
81MAF_26560356_Chip-Seq_TH1_Human1.19594624
82CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19146096
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18330686
84MAF_26560356_Chip-Seq_TH2_Human1.18056711
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17167203
86GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16420353
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15167995
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14569832
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14160961
90MYC_18940864_ChIP-ChIP_HL60_Human1.13992850
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13389826
92UTX_26944678_Chip-Seq_JUKART_Human1.13326500
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12762728
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12012395
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.11360943
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11108442
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11095332
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11067768
99VDR_24763502_ChIP-Seq_THP-1_Human1.11041211
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10835453
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09566277
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.08911691
103MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08854893
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08568974
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06781181
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05467821
107RUNX1_22412390_ChIP-Seq_EML_Mouse1.05440891
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05325976
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05233295
110KDM5A_27292631_Chip-Seq_BREAST_Human1.03623638
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01942930
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01006941
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00944010
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00572662
115MYB_26560356_Chip-Seq_TH2_Human1.00313635
116RNF2_27304074_Chip-Seq_NSC_Mouse0.98807212
117* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97928682
118FOXP1_21924763_ChIP-Seq_HESCs_Human0.97278312
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97097612
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96734296
121ELK1_22589737_ChIP-Seq_MCF10A_Human0.95854525
122PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95725326
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.94917727
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94283690
125MYB_26560356_Chip-Seq_TH1_Human0.94146556
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93208738
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92510962
128CTCF_26484167_Chip-Seq_Bcells_Mouse0.91637481
129CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87793903
130CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85327295
131RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84702676
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81077188
133* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79843008
134FUS_26573619_Chip-Seq_HEK293_Human0.78326085
135NANOG_18555785_ChIP-Seq_MESCs_Mouse0.77307276
136ERA_21632823_ChIP-Seq_H3396_Human0.76667484
137FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75092949
138* YY1_22570637_ChIP-Seq_MALME-3M_Human0.73316627
139MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.73172938
140FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72910979
141NCOR_22424771_ChIP-Seq_293T_Human0.72765117
142PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71854485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.57382396
2MP0006292_abnormal_olfactory_placode4.14898130
3MP0003693_abnormal_embryo_hatching3.15763330
4MP0002396_abnormal_hematopoietic_system2.69466404
5MP0003763_abnormal_thymus_physiology2.54671863
6MP0001529_abnormal_vocalization2.50651838
7MP0003123_paternal_imprinting2.44639631
8MP0002234_abnormal_pharynx_morphology2.38624460
9MP0008789_abnormal_olfactory_epithelium2.38139711
10MP0003656_abnormal_erythrocyte_physiolo2.32989303
11MP0004145_abnormal_muscle_electrophysio2.31497360
12MP0001835_abnormal_antigen_presentation2.29953742
13MP0004957_abnormal_blastocyst_morpholog2.25590417
14MP0002132_abnormal_respiratory_system2.20502754
15MP0000685_abnormal_immune_system2.11639839
16MP0010094_abnormal_chromosome_stability2.09637915
17MP0000490_abnormal_crypts_of2.06562543
18MP0005410_abnormal_fertilization2.05737158
19MP0001545_abnormal_hematopoietic_system2.04537265
20MP0005397_hematopoietic_system_phenotyp2.04537265
21MP0005174_abnormal_tail_pigmentation2.02175211
22MP0005499_abnormal_olfactory_system1.96512460
23MP0005394_taste/olfaction_phenotype1.96512460
24MP0002653_abnormal_ependyma_morphology1.96429554
25MP0006036_abnormal_mitochondrial_physio1.93553407
26MP0006072_abnormal_retinal_apoptosis1.93507308
27MP0002139_abnormal_hepatobiliary_system1.92981239
28MP0006276_abnormal_autonomic_nervous1.92886616
29MP0008057_abnormal_DNA_replication1.92725308
30MP0003787_abnormal_imprinting1.91305332
31MP0002398_abnormal_bone_marrow1.87746054
32MP0001800_abnormal_humoral_immune1.85666164
33MP0009333_abnormal_splenocyte_physiolog1.83053115
34MP0005671_abnormal_response_to1.80251388
35MP0005025_abnormal_response_to1.80237687
36MP0003077_abnormal_cell_cycle1.79249869
37MP0003806_abnormal_nucleotide_metabolis1.78418634
38MP0005075_abnormal_melanosome_morpholog1.75875787
39MP0005084_abnormal_gallbladder_morpholo1.75618863
40MP0009785_altered_susceptibility_to1.74832803
41MP0003121_genomic_imprinting1.74095776
42MP0002837_dystrophic_cardiac_calcinosis1.69870645
43MP0003880_abnormal_central_pattern1.68803475
44MP0003186_abnormal_redox_activity1.68269938
45MP0004142_abnormal_muscle_tone1.68140600
46MP0001293_anophthalmia1.67591163
47MP0005360_urolithiasis1.63992948
48MP0000689_abnormal_spleen_morphology1.62178557
49MP0003111_abnormal_nucleus_morphology1.61700363
50MP0001984_abnormal_olfaction1.61093651
51MP0001853_heart_inflammation1.60529330
52MP0002723_abnormal_immune_serum1.60094910
53MP0003436_decreased_susceptibility_to1.60075958
54MP0002722_abnormal_immune_system1.59740581
55MP0002736_abnormal_nociception_after1.58519542
56MP0002638_abnormal_pupillary_reflex1.57502288
57MP0002420_abnormal_adaptive_immunity1.57120722
58MP0004808_abnormal_hematopoietic_stem1.57105065
59MP0000716_abnormal_immune_system1.54579397
60MP0005085_abnormal_gallbladder_physiolo1.54264504
61MP0003011_delayed_dark_adaptation1.53829242
62MP0008877_abnormal_DNA_methylation1.53684121
63MP0001819_abnormal_immune_cell1.53368369
64MP0004133_heterotaxia1.53297018
65MP0000631_abnormal_neuroendocrine_gland1.53242126
66MP0002452_abnormal_antigen_presenting1.50703948
67MP0002429_abnormal_blood_cell1.50596301
68MP0003136_yellow_coat_color1.47738582
69MP0010155_abnormal_intestine_physiology1.46666117
70MP0002938_white_spotting1.46533179
71MP0000703_abnormal_thymus_morphology1.45724691
72MP0000372_irregular_coat_pigmentation1.45359980
73MP0002166_altered_tumor_susceptibility1.44665856
74MP0003866_abnormal_defecation1.44472368
75MP0004147_increased_porphyrin_level1.44446476
76MP0001873_stomach_inflammation1.43962832
77MP0002160_abnormal_reproductive_system1.43356579
78MP0005000_abnormal_immune_tolerance1.42849606
79MP0008875_abnormal_xenobiotic_pharmacok1.42379621
80MP0005083_abnormal_biliary_tract1.42216786
81MP0001905_abnormal_dopamine_level1.41999440
82MP0004381_abnormal_hair_follicle1.41716320
83MP0005365_abnormal_bile_salt1.40831466
84MP0005464_abnormal_platelet_physiology1.39979436
85MP0008058_abnormal_DNA_repair1.39860048
86MP0000049_abnormal_middle_ear1.39452287
87MP0001790_abnormal_immune_system1.38723257
88MP0005387_immune_system_phenotype1.38723257
89MP0002405_respiratory_system_inflammati1.37274015
90MP0005646_abnormal_pituitary_gland1.36855903
91MP0003786_premature_aging1.36374012
92MP0001968_abnormal_touch/_nociception1.34068901
93MP0003724_increased_susceptibility_to1.31718002
94MP0002148_abnormal_hypersensitivity_rea1.31639627
95MP0001986_abnormal_taste_sensitivity1.30719200
96MP0005645_abnormal_hypothalamus_physiol1.29303108
97MP0002102_abnormal_ear_morphology1.29235050
98MP0009840_abnormal_foam_cell1.28067348
99MP0002019_abnormal_tumor_incidence1.27660854
100MP0003567_abnormal_fetal_cardiomyocyte1.26641745
101MP0002928_abnormal_bile_duct1.26427629
102MP0001663_abnormal_digestive_system1.26232596
103MP0002751_abnormal_autonomic_nervous1.25810892
104MP0000465_gastrointestinal_hemorrhage1.24005817
105MP0008007_abnormal_cellular_replicative1.23973835
106MP0003315_abnormal_perineum_morphology1.21815247
107MP0003122_maternal_imprinting1.18758151
108MP0005636_abnormal_mineral_homeostasis1.18442556
109MP0003718_maternal_effect1.17684541
110MP0006035_abnormal_mitochondrial_morpho1.17504283
111MP0008469_abnormal_protein_level1.16448512
112MP0002277_abnormal_respiratory_mucosa1.15896447
113MP0001188_hyperpigmentation1.15583545
114MP0002095_abnormal_skin_pigmentation1.14890411
115MP0005451_abnormal_body_composition1.14254069
116MP0002163_abnormal_gland_morphology1.14250984
117MP0005389_reproductive_system_phenotype1.12353204
118MP0005551_abnormal_eye_electrophysiolog1.11998912
119MP0005423_abnormal_somatic_nervous1.11245304
120MP0001845_abnormal_inflammatory_respons1.11045207
121MP0001764_abnormal_homeostasis1.09503391
122MP0001919_abnormal_reproductive_system1.09409815
123MP0005379_endocrine/exocrine_gland_phen1.09070119
124MP0000778_abnormal_nervous_system1.08590957
125MP0001929_abnormal_gametogenesis1.08464691
126MP0008995_early_reproductive_senescence1.06271277
127MP0002752_abnormal_somatic_nervous1.06097792
128MP0002419_abnormal_innate_immunity1.05870281
129MP0000313_abnormal_cell_death1.04190915
130MP0002272_abnormal_nervous_system1.02992900
131MP0002184_abnormal_innervation1.02333007
132MP0001485_abnormal_pinna_reflex1.01964794
133MP0003646_muscle_fatigue1.00331214
134MP0008932_abnormal_embryonic_tissue0.99255018
135MP0009046_muscle_twitch0.97508701
136MP0000858_altered_metastatic_potential0.97051275
137MP0000750_abnormal_muscle_regeneration0.96881056
138MP0001286_abnormal_eye_development0.95425549
139MP0005195_abnormal_posterior_eye0.94191809
140MP0009745_abnormal_behavioral_response0.93255858
141MP0009278_abnormal_bone_marrow0.92894968
142MP0000955_abnormal_spinal_cord0.92195546
143MP0005220_abnormal_exocrine_pancreas0.92085713
144MP0008872_abnormal_physiological_respon0.91904649
145MP0005253_abnormal_eye_physiology0.91895794
146MP0001666_abnormal_nutrient_absorption0.91433402
147MP0003191_abnormal_cellular_cholesterol0.91413825
148MP0000653_abnormal_sex_gland0.89048807
149MP0005319_abnormal_enzyme/_coenzyme0.88736340
150MP0002006_tumorigenesis0.88511406
151MP0002557_abnormal_social/conspecific_i0.86255832
152MP0004742_abnormal_vestibular_system0.85253559
153MP0002733_abnormal_thermal_nociception0.85126037
154MP0002210_abnormal_sex_determination0.84531080
155MP0003942_abnormal_urinary_system0.83164896
156MP0002138_abnormal_hepatobiliary_system0.82574837
157MP0010030_abnormal_orbit_morphology0.80884447
158MP0001119_abnormal_female_reproductive0.80836594
159MP0006054_spinal_hemorrhage0.80621310
160MP0005501_abnormal_skin_physiology0.80290470
161MP0005391_vision/eye_phenotype0.77799812
162MP0000026_abnormal_inner_ear0.77633313
163MP0003303_peritoneal_inflammation0.77594818
164MP0001145_abnormal_male_reproductive0.77143254
165MP0005381_digestive/alimentary_phenotyp0.77140832
166MP0000609_abnormal_liver_physiology0.76356812
167MP0002796_impaired_skin_barrier0.75043426
168MP0003698_abnormal_male_reproductive0.75043195
169MP0002233_abnormal_nose_morphology0.73396848
170MP0009764_decreased_sensitivity_to0.73341119
171MP0000358_abnormal_cell_content/0.73250872
172MP0002882_abnormal_neuron_morphology0.73243134
173MP0001502_abnormal_circadian_rhythm0.73001851
174MP0001970_abnormal_pain_threshold0.71427867
175MP0003890_abnormal_embryonic-extraembry0.68839733

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.36799590
2Abnormal number of erythroid precursors (HP:0012131)6.97793810
3Reticulocytopenia (HP:0001896)6.59732683
4Pallor (HP:0000980)4.84007643
5Macrocytic anemia (HP:0001972)4.81913706
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.90361355
7Decreased activity of mitochondrial respiratory chain (HP:0008972)3.90361355
8Thrombocytosis (HP:0001894)3.86597039
9Hepatocellular necrosis (HP:0001404)3.82373834
10Hepatic necrosis (HP:0002605)3.73493998
11Abnormality of the heme biosynthetic pathway (HP:0010472)3.63407651
12Mitochondrial inheritance (HP:0001427)3.54944490
13Increased hepatocellular lipid droplets (HP:0006565)3.54525993
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.47992681
15Lipid accumulation in hepatocytes (HP:0006561)3.39970175
16Increased intramyocellular lipid droplets (HP:0012240)3.39274588
17Aplastic anemia (HP:0001915)3.32561520
18Abnormality of midbrain morphology (HP:0002418)3.26870130
19Molar tooth sign on MRI (HP:0002419)3.26870130
20Increased muscle lipid content (HP:0009058)3.21464649
21Nasal polyposis (HP:0100582)3.15726143
22Increased CSF lactate (HP:0002490)3.14233928
233-Methylglutaconic aciduria (HP:0003535)3.11417642
24Exertional dyspnea (HP:0002875)3.07500718
25Acute necrotizing encephalopathy (HP:0006965)3.02938592
26Aplasia/Hypoplasia of the sacrum (HP:0008517)3.00149088
27Abnormal hemoglobin (HP:0011902)3.00127686
28Abnormality of reticulocytes (HP:0004312)2.98016713
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.95961761
30Pancreatic fibrosis (HP:0100732)2.95384664
31Abnormal mitochondria in muscle tissue (HP:0008316)2.93755966
32Chronic otitis media (HP:0000389)2.86445546
33Abnormality of the nasal mucosa (HP:0000433)2.85378083
34Increased serum lactate (HP:0002151)2.85375852
35Renal Fanconi syndrome (HP:0001994)2.85315575
36Pancreatic cysts (HP:0001737)2.81741419
37Petechiae (HP:0000967)2.72801182
38Reduced antithrombin III activity (HP:0001976)2.70467464
39Respiratory difficulties (HP:0002880)2.68270749
40Recurrent bronchitis (HP:0002837)2.65118228
41Medial flaring of the eyebrow (HP:0010747)2.63454797
42True hermaphroditism (HP:0010459)2.62900095
43Acute encephalopathy (HP:0006846)2.59360177
44Pancytopenia (HP:0001876)2.55980503
45IgM deficiency (HP:0002850)2.55940733
46Prolonged bleeding time (HP:0003010)2.55151969
47Lactic acidosis (HP:0003128)2.52769110
48Optic disc pallor (HP:0000543)2.45475331
49Oral leukoplakia (HP:0002745)2.44895525
50Sclerocornea (HP:0000647)2.44614213
51Type 2 muscle fiber atrophy (HP:0003554)2.42668203
52Gait imbalance (HP:0002141)2.41459674
53Progressive macrocephaly (HP:0004481)2.37562856
54Absent thumb (HP:0009777)2.37360388
55Multiple enchondromatosis (HP:0005701)2.36408725
56Microcytic anemia (HP:0001935)2.36229942
57Panhypogammaglobulinemia (HP:0003139)2.33211269
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.32597330
59Cerebral edema (HP:0002181)2.28291359
60Elevated erythrocyte sedimentation rate (HP:0003565)2.27719508
61Bile duct proliferation (HP:0001408)2.26675915
62Abnormal biliary tract physiology (HP:0012439)2.26675915
63Nephronophthisis (HP:0000090)2.26465970
64Microvesicular hepatic steatosis (HP:0001414)2.25978583
65Abnormality of T cell physiology (HP:0011840)2.25936287
66Septo-optic dysplasia (HP:0100842)2.25815877
67Congenital primary aphakia (HP:0007707)2.23840347
68Exercise intolerance (HP:0003546)2.20906112
69Dicarboxylic aciduria (HP:0003215)2.18922836
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18922836
71Respiratory failure (HP:0002878)2.16195555
72Hyperglycinemia (HP:0002154)2.15131761
73Nephrogenic diabetes insipidus (HP:0009806)2.15078703
74Bronchitis (HP:0012387)2.14554285
75Abnormality of pyrimidine metabolism (HP:0004353)2.14452772
76Type I transferrin isoform profile (HP:0003642)2.13566325
77Type II lissencephaly (HP:0007260)2.10261847
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.08417880
79Epistaxis (HP:0000421)2.07240825
80Retinal dysplasia (HP:0007973)2.06063193
81Leukodystrophy (HP:0002415)2.03697147
82Ragged-red muscle fibers (HP:0003200)2.01304790
83Anencephaly (HP:0002323)1.99520993
84Agammaglobulinemia (HP:0004432)1.99277223
8511 pairs of ribs (HP:0000878)1.99174206
86Focal motor seizures (HP:0011153)1.99037339
87Hyperphosphaturia (HP:0003109)1.98638565
88Recurrent sinusitis (HP:0011108)1.98390234
89Rib fusion (HP:0000902)1.98120683
90Microretrognathia (HP:0000308)1.97800800
91Impaired platelet aggregation (HP:0003540)1.97331174
92Abnormal platelet function (HP:0011869)1.97331174
93Methylmalonic aciduria (HP:0012120)1.97259993
94Increased serum pyruvate (HP:0003542)1.96515879
95Colon cancer (HP:0003003)1.94073047
96Methylmalonic acidemia (HP:0002912)1.93533220
97Abnormality of T cells (HP:0002843)1.93172552
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92294820
99Cerebral hypomyelination (HP:0006808)1.92008260
100Abnormality of B cell number (HP:0010975)1.90962533
101B lymphocytopenia (HP:0010976)1.90962533
102Abnormality of renal resorption (HP:0011038)1.88891807
103Hypochromic anemia (HP:0001931)1.88754008
104Chronic sinusitis (HP:0011109)1.88740746
105Abnormality of urine glucose concentration (HP:0011016)1.87613512
106Glycosuria (HP:0003076)1.87613512
107Recurrent viral infections (HP:0004429)1.86180265
108Occipital encephalocele (HP:0002085)1.85525755
109Absent septum pellucidum (HP:0001331)1.84883757
110Abnormality of the preputium (HP:0100587)1.84519187
111Increased serum ferritin (HP:0003281)1.84379722
112Gastrointestinal inflammation (HP:0004386)1.83268410
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.82447331
114* Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81321243
115Congenital stationary night blindness (HP:0007642)1.81041854
116Aganglionic megacolon (HP:0002251)1.80675415
117Anophthalmia (HP:0000528)1.80545729
118Progressive microcephaly (HP:0000253)1.79634730
119Abnormality of alanine metabolism (HP:0010916)1.78420022
120Hyperalaninemia (HP:0003348)1.78420022
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78420022
122Meningitis (HP:0001287)1.77619411
123Triphalangeal thumb (HP:0001199)1.77514386
124Purpura (HP:0000979)1.75104639
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74393067
126Abnormal protein N-linked glycosylation (HP:0012347)1.74393067
127Abnormal protein glycosylation (HP:0012346)1.74393067
128Abnormal glycosylation (HP:0012345)1.74393067
129Male pseudohermaphroditism (HP:0000037)1.74217542
130Abnormal spermatogenesis (HP:0008669)1.73948556
131Horseshoe kidney (HP:0000085)1.73281109
132Myelodysplasia (HP:0002863)1.71787668
133Generalized aminoaciduria (HP:0002909)1.71619243
134Inflammation of the large intestine (HP:0002037)1.70823665
135Hypobetalipoproteinemia (HP:0003563)1.70494013
136Progressive muscle weakness (HP:0003323)1.70261734
137Abnormality of the renal medulla (HP:0100957)1.70212492
138Muscle fiber atrophy (HP:0100295)1.69482325
139Depressed nasal ridge (HP:0000457)1.69215497
140Hypothermia (HP:0002045)1.69069338
141Meckel diverticulum (HP:0002245)1.68688301
142* Abnormal rod and cone electroretinograms (HP:0008323)1.67174166
143Postaxial foot polydactyly (HP:0001830)1.65622585
144Neutropenia (HP:0001875)1.65589917
145Aplasia/Hypoplasia of the thymus (HP:0010515)1.65004975
146Cystic liver disease (HP:0006706)1.64860141
147Lethargy (HP:0001254)1.64686057
148CNS demyelination (HP:0007305)1.64599560
149Abnormal number of incisors (HP:0011064)1.63049212
150Delayed CNS myelination (HP:0002188)1.62854655
151Oculomotor apraxia (HP:0000657)1.61405562
152Emotional lability (HP:0000712)1.61299503
153Limb dystonia (HP:0002451)1.60753578
154Abnormality of the anterior horn cell (HP:0006802)1.60527628
155Degeneration of anterior horn cells (HP:0002398)1.60527628
156Absence seizures (HP:0002121)1.60018772
157Abnormality of the ileum (HP:0001549)1.59091133

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.36868820
2TLK14.26368776
3VRK23.37886941
4MAP4K12.80563689
5STK162.77984223
6ZAK2.74903482
7BCKDK2.32871629
8CDK192.20854106
9DYRK22.18287996
10BMPR1B2.16282899
11BLK2.14420597
12EIF2AK12.09571668
13WEE12.08535871
14MAP2K72.05653259
15EEF2K1.95418396
16BUB11.87690266
17VRK11.87104583
18PIM21.79778669
19DYRK31.75046149
20MAP4K21.71579257
21FLT31.69708965
22MAP3K101.68550476
23PLK41.65257306
24CDC71.61401295
25TEC1.58180632
26LIMK11.57539614
27MAPK131.56769382
28LRRK21.53314639
29GRK61.52043525
30BTK1.51885528
31ZAP701.50194379
32SRPK11.49497900
33TRIM281.48074762
34NEK21.47484927
35IRAK41.43963475
36RPS6KB21.42138186
37ARAF1.42103639
38TYK21.41640489
39PKN21.41310165
40KIT1.37522397
41MAP3K41.32045884
42WNK31.30073765
43EIF2AK31.28332079
44ACVR1B1.27802260
45MARK11.26439678
46TBK11.25607397
47MUSK1.21542949
48SYK1.20093236
49ERN11.18625057
50KDR1.17183708
51MAP3K111.16892879
52NUAK11.08103990
53NEK11.07294425
54TGFBR11.06608967
55PIM11.06362787
56CCNB11.05774487
57GRK11.05051496
58CDK71.04272894
59NME11.03947698
60IKBKE1.03750938
61RPS6KA41.03650245
62MST41.03534393
63PDK41.02962317
64PDK31.02962317
65TAOK31.02254819
66MINK11.02000145
67WNK41.01257528
68MAPKAPK31.01224821
69ILK1.00352408
70PHKG10.99977672
71PHKG20.99977672
72MAPKAPK50.99512240
73PINK10.97041814
74BRAF0.96009410
75SIK30.92254445
76TXK0.92207764
77DMPK0.91878329
78AURKB0.90961369
79CSF1R0.89972690
80OBSCN0.89742998
81IKBKB0.89614755
82IRAK30.87402013
83CHEK20.86705171
84TESK20.86087605
85STK40.84282969
86SIK20.83047741
87PRKCG0.82949398
88LMTK20.81325747
89CDK80.81077323
90CDK40.80149576
91MAPK40.78677186
92MAP2K30.77692381
93PLK30.77617777
94SCYL20.77023860
95GRK70.75919183
96EPHB20.75607714
97MAP2K20.74845112
98NTRK30.73450984
99TTK0.72404292
100MAPK110.72018786
101PNCK0.71050934
102NLK0.71047163
103AURKA0.70570334
104LYN0.70028986
105STK100.69819589
106TESK10.67468277
107RPS6KA50.65928655
108PRKG20.65147152
109MAP2K60.64842891
110PLK10.64765803
111PASK0.64024509
112MYLK0.63686891
113MOS0.63300250
114CSNK2A20.62667186
115ATR0.61551825
116PBK0.61313950
117PKN10.60573108
118LCK0.60313859
119JAK30.59813643
120PRKCI0.59770902
121TNK20.59318277
122STK390.59261624
123ADRBK20.58443854
124CSNK2A10.58320455
125BCR0.57772080
126CSNK1G30.57023914
127TNIK0.55364467
128BRSK10.54905059
129NTRK20.54673588
130TRIB30.53173807
131ABL20.52871553
132FES0.52811796
133EIF2AK20.52493389
134FGFR40.52380901
135CASK0.52232820
136RPS6KA60.52115692
137BRSK20.51767594
138CSNK1G20.50500849
139TGFBR20.49774264
140CDK30.49586273
141ERBB40.49580227
142CSNK1E0.49232365
143MKNK20.49129746
144MAP3K80.48195702
145DAPK30.47038937
146MKNK10.46051757
147CHEK10.43835141
148MATK0.43338588
149DYRK1B0.42372304
150TSSK60.42264466
151RPS6KC10.42253975
152RPS6KL10.42253975
153HIPK20.41281348
154RAF10.39835653
155MAPK150.39510205
156CSNK1A10.39331351

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.93857475
2DNA replication_Homo sapiens_hsa030304.06587986
3Mismatch repair_Homo sapiens_hsa034303.02148125
4RNA polymerase_Homo sapiens_hsa030202.67973628
5Proteasome_Homo sapiens_hsa030502.55200301
6Pyrimidine metabolism_Homo sapiens_hsa002402.52215147
7Oxidative phosphorylation_Homo sapiens_hsa001902.47714651
8Parkinsons disease_Homo sapiens_hsa050122.40254159
9Base excision repair_Homo sapiens_hsa034102.34028190
10Homologous recombination_Homo sapiens_hsa034402.33903915
11* Spliceosome_Homo sapiens_hsa030402.16621955
12Protein export_Homo sapiens_hsa030602.03891442
13Sulfur relay system_Homo sapiens_hsa041222.03055569
14Nucleotide excision repair_Homo sapiens_hsa034201.97180034
15Huntingtons disease_Homo sapiens_hsa050161.76808831
16Folate biosynthesis_Homo sapiens_hsa007901.74530888
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71926788
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68743687
19One carbon pool by folate_Homo sapiens_hsa006701.66004447
20Primary immunodeficiency_Homo sapiens_hsa053401.61617860
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61345721
22Alzheimers disease_Homo sapiens_hsa050101.58748684
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57773084
24Phototransduction_Homo sapiens_hsa047441.54949351
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46442410
26Fanconi anemia pathway_Homo sapiens_hsa034601.44746278
27Non-homologous end-joining_Homo sapiens_hsa034501.41253424
28Pentose phosphate pathway_Homo sapiens_hsa000301.39069017
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.35519869
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31141364
31RNA transport_Homo sapiens_hsa030131.27349690
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.26472724
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25003322
34Basal transcription factors_Homo sapiens_hsa030221.20074913
35Purine metabolism_Homo sapiens_hsa002301.19335018
36RNA degradation_Homo sapiens_hsa030181.06484306
37Systemic lupus erythematosus_Homo sapiens_hsa053221.01992680
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01926523
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99242558
40Antigen processing and presentation_Homo sapiens_hsa046120.94437361
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94192504
42Asthma_Homo sapiens_hsa053100.91088225
43Cell cycle_Homo sapiens_hsa041100.86115301
44Glutathione metabolism_Homo sapiens_hsa004800.85373268
45Selenocompound metabolism_Homo sapiens_hsa004500.84982803
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.83586717
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81916089
48Collecting duct acid secretion_Homo sapiens_hsa049660.80179178
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78365301
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77263725
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77130894
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74551913
53Fatty acid degradation_Homo sapiens_hsa000710.72319685
54Herpes simplex infection_Homo sapiens_hsa051680.71875313
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70391336
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.67560054
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67038049
58Peroxisome_Homo sapiens_hsa041460.66794147
59Metabolic pathways_Homo sapiens_hsa011000.66333108
60Pyruvate metabolism_Homo sapiens_hsa006200.65873638
61Propanoate metabolism_Homo sapiens_hsa006400.65547483
62p53 signaling pathway_Homo sapiens_hsa041150.65212905
63Carbon metabolism_Homo sapiens_hsa012000.64945964
64Cardiac muscle contraction_Homo sapiens_hsa042600.64655064
65Regulation of autophagy_Homo sapiens_hsa041400.64567485
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63458295
67Histidine metabolism_Homo sapiens_hsa003400.62599036
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.61457836
69Hematopoietic cell lineage_Homo sapiens_hsa046400.61440561
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61282568
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61270320
72Olfactory transduction_Homo sapiens_hsa047400.60259120
73Chemical carcinogenesis_Homo sapiens_hsa052040.60204389
74Nicotine addiction_Homo sapiens_hsa050330.60036968
75B cell receptor signaling pathway_Homo sapiens_hsa046620.59473632
76Butanoate metabolism_Homo sapiens_hsa006500.57550065
77N-Glycan biosynthesis_Homo sapiens_hsa005100.55900881
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55826276
79beta-Alanine metabolism_Homo sapiens_hsa004100.54168700
80Biosynthesis of amino acids_Homo sapiens_hsa012300.53811009
81Retinol metabolism_Homo sapiens_hsa008300.52477742
82Epstein-Barr virus infection_Homo sapiens_hsa051690.52336739
83Acute myeloid leukemia_Homo sapiens_hsa052210.52207787
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50877666
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50638233
86Caffeine metabolism_Homo sapiens_hsa002320.50285564
87Other glycan degradation_Homo sapiens_hsa005110.50168349
88Nitrogen metabolism_Homo sapiens_hsa009100.49958417
89Measles_Homo sapiens_hsa051620.48484319
90Tryptophan metabolism_Homo sapiens_hsa003800.47374369
91Steroid biosynthesis_Homo sapiens_hsa001000.45008621
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43918375
93ABC transporters_Homo sapiens_hsa020100.43730902
94mRNA surveillance pathway_Homo sapiens_hsa030150.41319823
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.40106527
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40054149
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38855614
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38611546
99Galactose metabolism_Homo sapiens_hsa000520.38320924
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38016930
101Linoleic acid metabolism_Homo sapiens_hsa005910.37685578
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.36810265
103Arachidonic acid metabolism_Homo sapiens_hsa005900.36456249
104Fatty acid elongation_Homo sapiens_hsa000620.35240883
105Basal cell carcinoma_Homo sapiens_hsa052170.34465564
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33803795
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33364795
108Oocyte meiosis_Homo sapiens_hsa041140.31690508
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.31208409
110Sulfur metabolism_Homo sapiens_hsa009200.30719691
111Fat digestion and absorption_Homo sapiens_hsa049750.30538946
112Phenylalanine metabolism_Homo sapiens_hsa003600.30365319
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30055253
114Fatty acid metabolism_Homo sapiens_hsa012120.29069129
115Fructose and mannose metabolism_Homo sapiens_hsa000510.27463565
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27242168
117Taste transduction_Homo sapiens_hsa047420.26499620
118Viral carcinogenesis_Homo sapiens_hsa052030.26385385
119Leishmaniasis_Homo sapiens_hsa051400.24667775
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24615942
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24444312
122Rheumatoid arthritis_Homo sapiens_hsa053230.23596240
123Thyroid cancer_Homo sapiens_hsa052160.23404909
124Arginine and proline metabolism_Homo sapiens_hsa003300.23092603
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21127977
126Allograft rejection_Homo sapiens_hsa053300.20535598
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19938628
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19462177
129Autoimmune thyroid disease_Homo sapiens_hsa053200.19084172
130Hedgehog signaling pathway_Homo sapiens_hsa043400.17457907
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.15952627
132Morphine addiction_Homo sapiens_hsa050320.15932193
133Alcoholism_Homo sapiens_hsa050340.14158989
134GABAergic synapse_Homo sapiens_hsa047270.10948331
135Serotonergic synapse_Homo sapiens_hsa047260.10835072
136Graft-versus-host disease_Homo sapiens_hsa053320.09819803
137Dopaminergic synapse_Homo sapiens_hsa047280.08990130
138Type I diabetes mellitus_Homo sapiens_hsa049400.08451309

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