ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.01622290
2	seminiferous tubule development (GO:0072520)	3.96195418
3	translational termination (GO:0006415)	3.91480978
4	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.87533468
5	substrate-independent telencephalic tangential migration (GO:0021826)	3.87533468
6	viral transcription (GO:0019083)	3.85406565
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.70693413
8	cornea development in camera-type eye (GO:0061303)	3.65178466
9	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	3.65019017
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.58378382
11	ATP synthesis coupled proton transport (GO:0015986)	3.58378382
12	ribosomal small subunit assembly (GO:0000028)	3.57713683
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.57361749
14	auditory behavior (GO:0031223)	3.54557386
15	behavioral response to nicotine (GO:0035095)	3.50500854
16	nonmotile primary cilium assembly (GO:0035058)	3.47863774
17	cotranslational protein targeting to membrane (GO:0006613)	3.38990492
18	epithelial cilium movement (GO:0003351)	3.35594917
19	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.34738690
20	protein targeting to ER (GO:0045047)	3.32733083
21	positive regulation of gastrulation (GO:2000543)	3.27718825
22	neuron fate determination (GO:0048664)	3.22037594
23	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.20730219
24	protein complex biogenesis (GO:0070271)	3.20471978
25	intraciliary transport (GO:0042073)	3.19411556
26	somite development (GO:0061053)	3.18931902
27	cell proliferation in forebrain (GO:0021846)	3.18684338
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.17392443
29	NADH dehydrogenase complex assembly (GO:0010257)	3.17392443
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.17392443
31	ribosomal small subunit biogenesis (GO:0042274)	3.13206722
32	protein localization to endoplasmic reticulum (GO:0070972)	3.11816478
33	respiratory electron transport chain (GO:0022904)	3.10256657
34	electron transport chain (GO:0022900)	3.09760580
35	cellular protein complex disassembly (GO:0043624)	3.07943189
36	tongue development (GO:0043586)	3.02381343
37	mechanosensory behavior (GO:0007638)	3.01844389
38	translational elongation (GO:0006414)	3.00728629
39	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.00475338
40	regulation of cilium movement (GO:0003352)	2.99239314
41	negative regulation of appetite (GO:0032099)	2.98035271
42	negative regulation of response to food (GO:0032096)	2.98035271
43	pyrimidine nucleobase catabolic process (GO:0006208)	2.97861751
44	left/right pattern formation (GO:0060972)	2.95824023
45	dendritic spine morphogenesis (GO:0060997)	2.91391097
46	uterus development (GO:0060065)	2.87723473
47	retinal ganglion cell axon guidance (GO:0031290)	2.86579391
48	central nervous system myelination (GO:0022010)	2.85434317
49	axon ensheathment in central nervous system (GO:0032291)	2.85434317
50	cerebral cortex radially oriented cell migration (GO:0021799)	2.83933485
51	viral life cycle (GO:0019058)	2.83170437
52	mitochondrial respiratory chain complex assembly (GO:0033108)	2.82579214
53	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.80897080
54	axonal fasciculation (GO:0007413)	2.77507474
55	positive regulation of cAMP-mediated signaling (GO:0043950)	2.74121402
56	synaptic transmission, cholinergic (GO:0007271)	2.72568148
57	postsynaptic membrane organization (GO:0001941)	2.71281196
58	presynaptic membrane organization (GO:0097090)	2.71241253
59	cilium movement (GO:0003341)	2.69617500
60	protein K6-linked ubiquitination (GO:0085020)	2.69514978
61	regulation of response to food (GO:0032095)	2.68577407
62	protein-cofactor linkage (GO:0018065)	2.64417058
63	positive regulation of male gonad development (GO:2000020)	2.63195678
64	short-term memory (GO:0007614)	2.62654504
65	alkaloid metabolic process (GO:0009820)	2.60220034
66	protein complex disassembly (GO:0043241)	2.59028449
67	insulin secretion (GO:0030073)	2.57625561
68	transmission of nerve impulse (GO:0019226)	2.57517459
69	spinal cord association neuron differentiation (GO:0021527)	2.57511215
70	regulation of timing of cell differentiation (GO:0048505)	2.56636806
71	maturation of SSU-rRNA (GO:0030490)	2.56002685
72	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.55164620
73	macromolecular complex disassembly (GO:0032984)	2.54620901
74	hindbrain development (GO:0030902)	2.54591044
75	negative regulation of telomere maintenance (GO:0032205)	2.53472152
76	nephron epithelium morphogenesis (GO:0072088)	2.52815167
77	nephron tubule morphogenesis (GO:0072078)	2.52815167
78	chaperone-mediated protein transport (GO:0072321)	2.50250058
79	regulation of male gonad development (GO:2000018)	2.49796406
80	neuron recognition (GO:0008038)	2.47434198
81	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.47299818
82	ribosomal large subunit biogenesis (GO:0042273)	2.47007128
83	protein localization to synapse (GO:0035418)	2.45770330
84	auditory receptor cell stereocilium organization (GO:0060088)	2.45581614
85	neuronal action potential propagation (GO:0019227)	2.43950677
86	nucleobase catabolic process (GO:0046113)	2.42517236
87	behavioral response to ethanol (GO:0048149)	2.42383569
88	neuronal stem cell maintenance (GO:0097150)	2.41910913
89	cilium organization (GO:0044782)	2.41368490
90	axoneme assembly (GO:0035082)	2.40929514
91	translational initiation (GO:0006413)	2.40732567
92	chromatin remodeling at centromere (GO:0031055)	2.40646903
93	cilium assembly (GO:0042384)	2.39226219
94	limb bud formation (GO:0060174)	2.38368856
95	regulation of development, heterochronic (GO:0040034)	2.35929871
96	smoothened signaling pathway (GO:0007224)	2.34426566
97	response to auditory stimulus (GO:0010996)	2.34093966
98	dorsal/ventral pattern formation (GO:0009953)	2.33302291
99	cilium morphogenesis (GO:0060271)	2.32804840
100	regulation of appetite (GO:0032098)	2.32618062

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.12820986
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	5.07111650
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.94460587
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.52105157
5	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.54657722
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.49026914
7	VDR_22108803_ChIP-Seq_LS180_Human	2.48973994
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.46386537
9	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.41591142
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.39140447
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.34371403
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.23423141
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.12867836
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.11939912
15	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.99960435
16	EWS_26573619_Chip-Seq_HEK293_Human	1.96072456
17	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.93292919
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.83985715
19	FUS_26573619_Chip-Seq_HEK293_Human	1.83431268
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.82829988
21	RNF2_27304074_Chip-Seq_NSC_Mouse	1.82135393
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79002784
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.77851395
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.76252254
25	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.73006224
26	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.72833915
27	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.72489225
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72182944
29	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.69403887
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.68579875
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.66984487
32	REST_21632747_ChIP-Seq_MESCs_Mouse	1.65482100
33	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.63418506
34	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.58806149
35	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.58063496
36	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.56653041
37	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.55887322
38	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55442370
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.50307492
40	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.49801055
41	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.47863008
42	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.45518396
43	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.45226670
44	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.45226670
45	P300_19829295_ChIP-Seq_ESCs_Human	1.41332280
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.38022196
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.37861870
48	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.36088653
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.35359530
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31309126
51	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.30330736
52	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.30075716
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.25902346
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23737166
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23737166
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22453051
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21818295
58	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21534111
59	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.19845587
60	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19513132
61	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19075837
62	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.18937812
63	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.15764033
64	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.13382834
65	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.13023998
66	ELK1_19687146_ChIP-ChIP_HELA_Human	1.11771044
67	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.11630025
68	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.08574387
69	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.07776264
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06403246
71	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.06402111
72	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.06165185
73	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04873202
74	TP53_22573176_ChIP-Seq_HFKS_Human	1.02584161
75	SMAD4_21799915_ChIP-Seq_A2780_Human	1.01913849
76	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.01481489
77	AR_25329375_ChIP-Seq_VCAP_Human	1.00214676
78	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.99777959
79	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.99586401
80	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99194074
81	JUN_21703547_ChIP-Seq_K562_Human	0.97364284
82	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.96600167
83	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95950147
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95458477
85	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95277515
86	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.93284906
87	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.92684577
88	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.90910545
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.90266470
90	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.88821640
91	ER_23166858_ChIP-Seq_MCF-7_Human	0.88550404
92	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.88276850
93	TCF4_22108803_ChIP-Seq_LS180_Human	0.85832484
94	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.85346313
95	AR_21572438_ChIP-Seq_LNCaP_Human	0.84976435
96	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.84235506
97	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.83519744
98	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.83120271
99	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.83075125
100	RUNX2_22187159_ChIP-Seq_PCA_Human	0.81713982

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	6.29412317
2	MP0006292_abnormal_olfactory_placode	4.50205954
3	MP0002638_abnormal_pupillary_reflex	2.76836874
4	MP0003880_abnormal_central_pattern	2.61644184
5	MP0008789_abnormal_olfactory_epithelium	2.51276637
6	MP0003787_abnormal_imprinting	2.35130485
7	MP0003122_maternal_imprinting	2.25453860
8	MP0002938_white_spotting	2.22056116
9	MP0009379_abnormal_foot_pigmentation	2.21344720
10	MP0005083_abnormal_biliary_tract	2.05807958
11	MP0005187_abnormal_penis_morphology	2.01601278
12	MP0005394_taste/olfaction_phenotype	2.00390204
13	MP0005499_abnormal_olfactory_system	2.00390204
14	MP0000569_abnormal_digit_pigmentation	1.92685787
15	MP0002653_abnormal_ependyma_morphology	1.91589822
16	MP0003136_yellow_coat_color	1.89028902
17	MP0003011_delayed_dark_adaptation	1.81823185
18	MP0003121_genomic_imprinting	1.81429273
19	MP0000778_abnormal_nervous_system	1.77252545
20	MP0001529_abnormal_vocalization	1.72979026
21	MP0005551_abnormal_eye_electrophysiolog	1.71341204
22	MP0001984_abnormal_olfaction	1.70876901
23	MP0000372_irregular_coat_pigmentation	1.66496150
24	MP0001485_abnormal_pinna_reflex	1.64171990
25	MP0008877_abnormal_DNA_methylation	1.63478730
26	MP0009046_muscle_twitch	1.61581539
27	MP0005646_abnormal_pituitary_gland	1.60852610
28	MP0003123_paternal_imprinting	1.59398217
29	MP0003315_abnormal_perineum_morphology	1.55739603
30	MP0001968_abnormal_touch/_nociception	1.53966665
31	MP0002736_abnormal_nociception_after	1.51791838
32	MP0002234_abnormal_pharynx_morphology	1.49823885
33	MP0006072_abnormal_retinal_apoptosis	1.46689267
34	MP0002272_abnormal_nervous_system	1.42136162
35	MP0000049_abnormal_middle_ear	1.41782032
36	MP0001293_anophthalmia	1.41374718
37	MP0010030_abnormal_orbit_morphology	1.41303143
38	MP0004142_abnormal_muscle_tone	1.35950650
39	MP0004133_heterotaxia	1.35787633
40	MP0002557_abnormal_social/conspecific_i	1.34667446
41	MP0004885_abnormal_endolymph	1.31823253
42	MP0005171_absent_coat_pigmentation	1.30917567
43	MP0000631_abnormal_neuroendocrine_gland	1.28720852
44	MP0002160_abnormal_reproductive_system	1.28485356
45	MP0001919_abnormal_reproductive_system	1.27506968
46	MP0005389_reproductive_system_phenotype	1.26422631
47	MP0002184_abnormal_innervation	1.25571667
48	MP0005084_abnormal_gallbladder_morpholo	1.24956926
49	MP0009745_abnormal_behavioral_response	1.23841909
50	MP0002102_abnormal_ear_morphology	1.20240799
51	MP0000026_abnormal_inner_ear	1.20003075
52	MP0005253_abnormal_eye_physiology	1.19934946
53	MP0001486_abnormal_startle_reflex	1.19174133
54	MP0001905_abnormal_dopamine_level	1.17253258
55	MP0005423_abnormal_somatic_nervous	1.16238161
56	MP0002822_catalepsy	1.15800244
57	MP0006276_abnormal_autonomic_nervous	1.15713800
58	MP0002233_abnormal_nose_morphology	1.13108367
59	MP0002064_seizures	1.12242789
60	MP0002752_abnormal_somatic_nervous	1.11250107
61	MP0000955_abnormal_spinal_cord	1.09230495
62	MP0002572_abnormal_emotion/affect_behav	1.09038513
63	MP0005391_vision/eye_phenotype	1.04059939
64	MP0003635_abnormal_synaptic_transmissio	1.03564764
65	MP0004742_abnormal_vestibular_system	0.99057270
66	MP0003878_abnormal_ear_physiology	0.95433522
67	MP0005377_hearing/vestibular/ear_phenot	0.95433522
68	MP0005195_abnormal_posterior_eye	0.95429355
69	MP0004145_abnormal_muscle_electrophysio	0.93916228
70	MP0001970_abnormal_pain_threshold	0.93507764
71	MP0002063_abnormal_learning/memory/cond	0.93379181
72	MP0003186_abnormal_redox_activity	0.93099673
73	MP0002067_abnormal_sensory_capabilities	0.92547306
74	MP0003938_abnormal_ear_development	0.92381252
75	MP0002734_abnormal_mechanical_nocicepti	0.91451184
76	MP0002837_dystrophic_cardiac_calcinosis	0.91361587
77	MP0002882_abnormal_neuron_morphology	0.91308150
78	MP0000639_abnormal_adrenal_gland	0.90751000
79	MP0002733_abnormal_thermal_nociception	0.90339733
80	MP0003942_abnormal_urinary_system	0.90322865
81	MP0003755_abnormal_palate_morphology	0.89600099
82	MP0002876_abnormal_thyroid_physiology	0.88886828
83	MP0002095_abnormal_skin_pigmentation	0.87692610
84	MP0002735_abnormal_chemical_nociception	0.86925110
85	MP0001963_abnormal_hearing_physiology	0.83038894
86	MP0001502_abnormal_circadian_rhythm	0.81878786
87	MP0005645_abnormal_hypothalamus_physiol	0.80961522
88	MP0001324_abnormal_eye_pigmentation	0.80405490
89	MP0005503_abnormal_tendon_morphology	0.79825149
90	MP0004859_abnormal_synaptic_plasticity	0.78863114
91	MP0002152_abnormal_brain_morphology	0.77056090
92	MP0004924_abnormal_behavior	0.75378118
93	MP0005386_behavior/neurological_phenoty	0.75378118
94	MP0005257_abnormal_intraocular_pressure	0.75150360
95	MP0002092_abnormal_eye_morphology	0.74924073
96	MP0009250_abnormal_appendicular_skeleto	0.74306974
97	MP0005248_abnormal_Harderian_gland	0.74121234
98	MP0000534_abnormal_ureter_morphology	0.73569921
99	MP0008058_abnormal_DNA_repair	0.73382028
100	MP0001286_abnormal_eye_development	0.72242292

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Enlarged penis (HP:0000040)	4.14583789
2	Acute necrotizing encephalopathy (HP:0006965)	4.00649460
3	Septo-optic dysplasia (HP:0100842)	3.83113648
4	True hermaphroditism (HP:0010459)	3.67878538
5	Reticulocytopenia (HP:0001896)	3.60307529
6	Pancreatic fibrosis (HP:0100732)	3.54221936
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.54158762
8	Abnormality of cells of the erythroid lineage (HP:0012130)	3.52012394
9	Nephronophthisis (HP:0000090)	3.32278417
10	Progressive macrocephaly (HP:0004481)	3.24182234
11	Acute encephalopathy (HP:0006846)	3.22096354
12	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.16622640
13	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.16622640
14	Abnormal number of erythroid precursors (HP:0012131)	3.14699097
15	Molar tooth sign on MRI (HP:0002419)	3.13332480
16	Abnormality of midbrain morphology (HP:0002418)	3.13332480
17	Medial flaring of the eyebrow (HP:0010747)	3.10941514
18	Pancreatic cysts (HP:0001737)	3.07587377
19	Abnormality of the renal medulla (HP:0100957)	3.00237187
20	Congenital stationary night blindness (HP:0007642)	2.97917667
21	Mitochondrial inheritance (HP:0001427)	2.84263082
22	Gait imbalance (HP:0002141)	2.79674203
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.74449144
24	Optic nerve hypoplasia (HP:0000609)	2.74361305
25	Sclerocornea (HP:0000647)	2.71610045
26	Abnormality of the corticospinal tract (HP:0002492)	2.64680457
27	Increased CSF lactate (HP:0002490)	2.64426054
28	Congenital primary aphakia (HP:0007707)	2.61263427
29	3-Methylglutaconic aciduria (HP:0003535)	2.56796451
30	Type II lissencephaly (HP:0007260)	2.56170250
31	Oligodactyly (hands) (HP:0001180)	2.55096814
32	Limb dystonia (HP:0002451)	2.54983938
33	Focal motor seizures (HP:0011153)	2.52283413
34	Absent septum pellucidum (HP:0001331)	2.45526325
35	Gonadotropin excess (HP:0000837)	2.44653300
36	Rib fusion (HP:0000902)	2.40328069
37	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.40054386
38	Progressive microcephaly (HP:0000253)	2.39268559
39	Anophthalmia (HP:0000528)	2.37081853
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.36997446
41	Cerebral edema (HP:0002181)	2.34755475
42	Ectopic kidney (HP:0000086)	2.34112040
43	Absent thumb (HP:0009777)	2.31502512
44	Macrocytic anemia (HP:0001972)	2.31501038
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.31425674
46	Retinal dysplasia (HP:0007973)	2.30492322
47	Oligodactyly (HP:0012165)	2.28819475
48	Nephrogenic diabetes insipidus (HP:0009806)	2.26169887
49	Postaxial foot polydactyly (HP:0001830)	2.22324163
50	Bilateral microphthalmos (HP:0007633)	2.16031198
51	Cystic liver disease (HP:0006706)	2.12280987
52	Congenital hepatic fibrosis (HP:0002612)	2.11095635
53	Decreased testicular size (HP:0008734)	2.11038819
54	Hepatocellular necrosis (HP:0001404)	2.07656552
55	Median cleft lip (HP:0000161)	2.06766968
56	Myokymia (HP:0002411)	2.06204720
57	Absence seizures (HP:0002121)	2.05025863
58	Chronic hepatic failure (HP:0100626)	2.01198917
59	Genital tract atresia (HP:0001827)	2.00331186
60	Male pseudohermaphroditism (HP:0000037)	1.99687452
61	Fibular hypoplasia (HP:0003038)	1.98021327
62	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.95302191
63	Abnormality of the diencephalon (HP:0010662)	1.94485300
64	Postaxial hand polydactyly (HP:0001162)	1.94316178
65	Pendular nystagmus (HP:0012043)	1.94052201
66	Hypothermia (HP:0002045)	1.93904296
67	Vaginal atresia (HP:0000148)	1.93521702
68	Abnormality of DNA repair (HP:0003254)	1.92316575
69	Dialeptic seizures (HP:0011146)	1.92215322
70	Supernumerary spleens (HP:0009799)	1.91893430
71	Focal seizures (HP:0007359)	1.90133057
72	Short tibia (HP:0005736)	1.89995620
73	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.88705233
74	Optic disc pallor (HP:0000543)	1.88636592
75	Tubular atrophy (HP:0000092)	1.87057978
76	Hyperventilation (HP:0002883)	1.84422793
77	Hypoplasia of the fovea (HP:0007750)	1.82258439
78	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.82258439
79	Adrenal hypoplasia (HP:0000835)	1.81715263
80	Tubulointerstitial nephritis (HP:0001970)	1.79794398
81	Hepatic necrosis (HP:0002605)	1.79495240
82	Polyphagia (HP:0002591)	1.79030540
83	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.78027350
84	Abnormality of the septum pellucidum (HP:0007375)	1.76143716
85	Holoprosencephaly (HP:0001360)	1.75523149
86	Left ventricular hypertrophy (HP:0001712)	1.74989332
87	Aganglionic megacolon (HP:0002251)	1.73960585
88	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.73683711
89	Bony spicule pigmentary retinopathy (HP:0007737)	1.73594466
90	Poor suck (HP:0002033)	1.73566795
91	Atonic seizures (HP:0010819)	1.73492264
92	Hypoplasia of the ulna (HP:0003022)	1.73120207
93	Anencephaly (HP:0002323)	1.72937328
94	Optic nerve coloboma (HP:0000588)	1.72427371
95	Concave nail (HP:0001598)	1.71941292
96	Amblyopia (HP:0000646)	1.71707246
97	Hypoplastic pelvis (HP:0008839)	1.70892849
98	Aplasia/hypoplasia of the uterus (HP:0008684)	1.69854754
99	Exercise intolerance (HP:0003546)	1.67050573
100	Spastic tetraplegia (HP:0002510)	1.66401725

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK13	2.75589630
2	CASK	2.63278249
3	EPHA4	2.47688545
4	PINK1	2.39449388
5	ABL2	2.35673325
6	MAP4K2	2.10596927
7	EPHB2	2.09830713
8	WNK4	2.09227190
9	MARK1	2.08628442
10	ZAK	1.88920061
11	DAPK2	1.86514118
12	MAP3K4	1.79630781
13	PAK3	1.74048385
14	STK16	1.67829929
15	NTRK3	1.66994614
16	NUAK1	1.66225427
17	MAP2K7	1.57508882
18	PLK2	1.55077234
19	PRKCG	1.53795181
20	CDC7	1.52139740
21	FRK	1.51660298
22	GRK1	1.51067434
23	ADRBK2	1.49686435
24	BCKDK	1.48253557
25	DYRK2	1.47107972
26	CAMKK2	1.43801956
27	TLK1	1.40537561
28	WNK3	1.37463093
29	WEE1	1.37396902
30	MINK1	1.34018322
31	DMPK	1.32051599
32	STK39	1.30182273
33	CCNB1	1.26934378
34	PNCK	1.26443936
35	LIMK1	1.25522882
36	TAOK3	1.17876041
37	PHKG1	1.06697540
38	PHKG2	1.06697540
39	ADRBK1	1.06377614
40	NTRK2	1.04637894
41	PRKCE	1.04173236
42	DYRK3	1.01685351
43	BCR	1.00180058
44	MAPK15	0.98904969
45	CAMK1	0.97975256
46	BMPR1B	0.97918223
47	PLK4	0.96233950
48	EIF2AK1	0.89654746
49	MUSK	0.88361113
50	CSNK1G2	0.85756697
51	CAMK2A	0.82557259
52	RPS6KA4	0.81849065
53	VRK1	0.79356807
54	CAMK2G	0.78635474
55	TIE1	0.77596854
56	INSRR	0.77026939
57	PKN1	0.76721993
58	CAMK2D	0.76058900
59	NME1	0.75988638
60	CHUK	0.72069969
61	DYRK1B	0.70285226
62	OBSCN	0.69453200
63	STK38L	0.66711768
64	PRKACA	0.66041819
65	MAP3K9	0.65611408
66	CSNK1G3	0.64039658
67	AURKA	0.63795932
68	LRRK2	0.63151123
69	PLK3	0.63108457
70	GRK7	0.63025905
71	PAK6	0.63005533
72	CSNK1A1	0.61558751
73	PTK2B	0.60747565
74	TNIK	0.59323584
75	MARK2	0.57895387
76	CAMK2B	0.57433678
77	MAPKAPK5	0.54761407
78	MKNK2	0.53727773
79	KSR1	0.52301795
80	AURKB	0.50639040
81	CDK3	0.50185254
82	CSNK1E	0.49875453
83	LATS1	0.49858376
84	PRKCZ	0.49284647
85	PIK3CA	0.48437000
86	DYRK1A	0.48178362
87	PLK1	0.46967727
88	CAMKK1	0.46117737
89	ROCK1	0.45101169
90	CSNK2A2	0.44337027
91	TGFBR1	0.44250695
92	EIF2AK3	0.43893781
93	PRKD3	0.43702861
94	CSNK1G1	0.43609522
95	PRKACB	0.43531668
96	AKT3	0.43155696
97	CSNK2A1	0.42901167
98	MAP3K7	0.41910288
99	CDK18	0.41616522
100	CDK11A	0.40830260

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.13004173
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.92567622
3	Parkinsons disease_Homo sapiens_hsa05012	3.34897429
4	Protein export_Homo sapiens_hsa03060	3.08065140
5	Phototransduction_Homo sapiens_hsa04744	2.44295345
6	Alzheimers disease_Homo sapiens_hsa05010	2.31348571
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.26597601
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.25359482
9	Huntingtons disease_Homo sapiens_hsa05016	2.23500379
10	Homologous recombination_Homo sapiens_hsa03440	2.20828671
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.06684935
12	Insulin secretion_Homo sapiens_hsa04911	2.01632211
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95925160
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.83966316
15	Steroid biosynthesis_Homo sapiens_hsa00100	1.77791663
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.76513053
17	Nicotine addiction_Homo sapiens_hsa05033	1.73133740
18	Proteasome_Homo sapiens_hsa03050	1.64554191
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.52373711
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.51145838
21	Basal cell carcinoma_Homo sapiens_hsa05217	1.46002203
22	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.41294066
23	RNA polymerase_Homo sapiens_hsa03020	1.37535868
24	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.34538971
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33384386
26	Folate biosynthesis_Homo sapiens_hsa00790	1.32061540
27	Olfactory transduction_Homo sapiens_hsa04740	1.30576045
28	Butanoate metabolism_Homo sapiens_hsa00650	1.30314955
29	Morphine addiction_Homo sapiens_hsa05032	1.26932657
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.25990827
31	Cocaine addiction_Homo sapiens_hsa05030	1.23363521
32	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.19496022
33	Basal transcription factors_Homo sapiens_hsa03022	1.15668479
34	Dopaminergic synapse_Homo sapiens_hsa04728	1.15340166
35	Mismatch repair_Homo sapiens_hsa03430	1.14932183
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.13971361
37	Circadian entrainment_Homo sapiens_hsa04713	1.13821826
38	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.08763529
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.08175736
40	Glutamatergic synapse_Homo sapiens_hsa04724	1.05505361
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.05095555
42	Nucleotide excision repair_Homo sapiens_hsa03420	1.03897841
43	DNA replication_Homo sapiens_hsa03030	1.01996300
44	Base excision repair_Homo sapiens_hsa03410	1.01330451
45	GABAergic synapse_Homo sapiens_hsa04727	1.00435387
46	Sulfur relay system_Homo sapiens_hsa04122	1.00310172
47	Amphetamine addiction_Homo sapiens_hsa05031	0.98477423
48	Fatty acid elongation_Homo sapiens_hsa00062	0.98138167
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.96095456
50	Propanoate metabolism_Homo sapiens_hsa00640	0.91418650
51	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.89182977
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.88938316
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82788540
54	Calcium signaling pathway_Homo sapiens_hsa04020	0.80092873
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.79973563
56	Purine metabolism_Homo sapiens_hsa00230	0.78920167
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.76260493
58	Hippo signaling pathway_Homo sapiens_hsa04390	0.71386550
59	Pyruvate metabolism_Homo sapiens_hsa00620	0.70331906
60	Axon guidance_Homo sapiens_hsa04360	0.69154468
61	Metabolic pathways_Homo sapiens_hsa01100	0.68302908
62	Serotonergic synapse_Homo sapiens_hsa04726	0.66095476
63	One carbon pool by folate_Homo sapiens_hsa00670	0.65789499
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65542796
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.65065266
66	Peroxisome_Homo sapiens_hsa04146	0.64623039
67	Regulation of autophagy_Homo sapiens_hsa04140	0.64517952
68	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.63259819
69	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.63168933
70	RNA degradation_Homo sapiens_hsa03018	0.58935661
71	Melanogenesis_Homo sapiens_hsa04916	0.58591168
72	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.58525749
73	Tryptophan metabolism_Homo sapiens_hsa00380	0.58201248
74	Taste transduction_Homo sapiens_hsa04742	0.57360180
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54056306
76	Cholinergic synapse_Homo sapiens_hsa04725	0.52425297
77	Nitrogen metabolism_Homo sapiens_hsa00910	0.51955629
78	Alcoholism_Homo sapiens_hsa05034	0.51383378
79	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.50622014
80	Wnt signaling pathway_Homo sapiens_hsa04310	0.49399868
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.47956992
82	Spliceosome_Homo sapiens_hsa03040	0.45347330
83	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.45340386
84	Long-term depression_Homo sapiens_hsa04730	0.43877636
85	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.43753644
86	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.43509207
87	Salivary secretion_Homo sapiens_hsa04970	0.43390897
88	Gastric acid secretion_Homo sapiens_hsa04971	0.42833866
89	Linoleic acid metabolism_Homo sapiens_hsa00591	0.42169482
90	Glutathione metabolism_Homo sapiens_hsa00480	0.41664477
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39350951
92	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.37846159
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34472302
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.32623822
95	Renin secretion_Homo sapiens_hsa04924	0.32413647
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.31491081
97	Sulfur metabolism_Homo sapiens_hsa00920	0.30654994
98	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.29972626
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.29622072
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.28467113

RP9P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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