RPA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.04119651
2DNA replication initiation (GO:0006270)5.34553316
3* DNA strand elongation involved in DNA replication (GO:0006271)5.32872001
4protein localization to kinetochore (GO:0034501)5.11808030
5* DNA strand elongation (GO:0022616)5.03791684
6DNA replication-dependent nucleosome assembly (GO:0006335)4.83104682
7DNA replication-dependent nucleosome organization (GO:0034723)4.83104682
8* telomere maintenance via semi-conservative replication (GO:0032201)4.73963098
9nuclear pore organization (GO:0006999)4.67783596
10nuclear pore complex assembly (GO:0051292)4.59676899
11folic acid-containing compound biosynthetic process (GO:0009396)4.56435645
12mitotic nuclear envelope disassembly (GO:0007077)4.42757028
13protein localization to chromosome, centromeric region (GO:0071459)4.34669564
14IMP biosynthetic process (GO:0006188)4.31618114
15mitotic chromosome condensation (GO:0007076)4.26700786
16* telomere maintenance via recombination (GO:0000722)4.21040425
17* mitotic recombination (GO:0006312)4.17714051
18mitotic sister chromatid segregation (GO:0000070)4.16143556
19membrane disassembly (GO:0030397)4.13756069
20nuclear envelope disassembly (GO:0051081)4.13756069
21DNA replication checkpoint (GO:0000076)4.13692119
22DNA duplex unwinding (GO:0032508)4.09457748
23DNA geometric change (GO:0032392)4.07429183
24sister chromatid segregation (GO:0000819)4.00529943
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.98889381
26somatic diversification of immune receptors via somatic mutation (GO:0002566)3.98889381
27nucleobase biosynthetic process (GO:0046112)3.97512155
28DNA ligation (GO:0006266)3.92881040
29establishment of viral latency (GO:0019043)3.91309161
30IMP metabolic process (GO:0046040)3.88723270
31formation of translation preinitiation complex (GO:0001731)3.80983531
32* nucleotide-excision repair, DNA gap filling (GO:0006297)3.77390288
33* telomere maintenance via telomere lengthening (GO:0010833)3.75255485
34mitotic metaphase plate congression (GO:0007080)3.68004965
35deoxyribonucleotide biosynthetic process (GO:0009263)3.64724815
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.62058859
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.61159905
38chromatin remodeling at centromere (GO:0031055)3.59297405
39translesion synthesis (GO:0019985)3.56135483
40maturation of SSU-rRNA (GO:0030490)3.55736606
41ribosomal small subunit assembly (GO:0000028)3.54966974
42regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.54637295
43pore complex assembly (GO:0046931)3.52384287
44regulation of translational termination (GO:0006449)3.49458150
45CENP-A containing nucleosome assembly (GO:0034080)3.49150909
46postreplication repair (GO:0006301)3.48162417
47regulation of translational fidelity (GO:0006450)3.45552672
48DNA replication-independent nucleosome assembly (GO:0006336)3.44101893
49DNA replication-independent nucleosome organization (GO:0034724)3.44101893
50DNA conformation change (GO:0071103)3.40979172
51attachment of spindle microtubules to kinetochore (GO:0008608)3.40332052
52purine nucleobase biosynthetic process (GO:0009113)3.37826206
53non-recombinational repair (GO:0000726)3.35885917
54double-strand break repair via nonhomologous end joining (GO:0006303)3.35885917
55regulation of histone H3-K9 methylation (GO:0051570)3.32051640
56L-serine metabolic process (GO:0006563)3.32032147
57metaphase plate congression (GO:0051310)3.31708094
58regulation of spindle organization (GO:0090224)3.31116953
59mitotic sister chromatid cohesion (GO:0007064)3.30533320
60ATP-dependent chromatin remodeling (GO:0043044)3.26266842
61positive regulation of chromosome segregation (GO:0051984)3.26191567
62kinetochore organization (GO:0051383)3.24650770
63chromatin assembly or disassembly (GO:0006333)3.24031521
64heterochromatin organization (GO:0070828)3.23086815
65regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.23064913
66regulation of centrosome cycle (GO:0046605)3.22393434
67nuclear envelope organization (GO:0006998)3.21932835
68establishment of chromosome localization (GO:0051303)3.21019069
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17911519
70chromosome condensation (GO:0030261)3.15745969
71regulation of chromosome segregation (GO:0051983)3.15451566
72histone exchange (GO:0043486)3.13240991
73protein localization to chromosome (GO:0034502)3.13141352
74regulation of gene silencing by RNA (GO:0060966)3.10939997
75regulation of posttranscriptional gene silencing (GO:0060147)3.10939997
76regulation of gene silencing by miRNA (GO:0060964)3.10939997
77* telomere maintenance (GO:0000723)3.10610480
78* telomere organization (GO:0032200)3.10325287
79nucleobase-containing small molecule interconversion (GO:0015949)3.08950898
80viral transcription (GO:0019083)3.07893690
81microtubule depolymerization (GO:0007019)3.06254340
82negative regulation of mRNA processing (GO:0050686)3.06024381
83negative regulation of chromosome segregation (GO:0051985)3.05865950
84peptidyl-arginine omega-N-methylation (GO:0035247)3.05791887
85translational termination (GO:0006415)3.05594868
86chromatin assembly (GO:0031497)3.05007777
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02802700
88proline biosynthetic process (GO:0006561)3.01406494
89negative regulation of histone methylation (GO:0031061)3.00957968
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00503379
91spliceosomal tri-snRNP complex assembly (GO:0000244)3.00149613
92positive regulation of DNA-dependent DNA replication (GO:2000105)3.00147395
93negative regulation of mitotic sister chromatid separation (GO:2000816)2.99375962
94negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99375962
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.99375962
96negative regulation of sister chromatid segregation (GO:0033046)2.99375962
97regulation of centriole replication (GO:0046599)2.99113244
98spindle checkpoint (GO:0031577)2.98080398
99translational elongation (GO:0006414)2.97993208
100chromosome segregation (GO:0007059)2.97347379
101meiotic chromosome segregation (GO:0045132)2.97333368
102spindle assembly checkpoint (GO:0071173)2.95533963
103ribosome assembly (GO:0042255)2.95326721
104* mitotic cell cycle (GO:0000278)2.94012571
105negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.94011197
106* G1/S transition of mitotic cell cycle (GO:0000082)2.92727278
107* cell cycle G1/S phase transition (GO:0044843)2.92727278
108regulation of sister chromatid cohesion (GO:0007063)2.92305109
109dosage compensation (GO:0007549)2.92093740
110regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91895152
111pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.91872560
112mitotic spindle assembly checkpoint (GO:0007094)2.91716621
113translational initiation (GO:0006413)2.90970675
114V(D)J recombination (GO:0033151)2.90554234
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90329314
116DNA synthesis involved in DNA repair (GO:0000731)2.90098636
117protein K6-linked ubiquitination (GO:0085020)2.89156173
118regulation of mitotic spindle organization (GO:0060236)2.88967343
119DNA packaging (GO:0006323)2.87571370
120establishment of integrated proviral latency (GO:0075713)2.87178425
121mitotic spindle checkpoint (GO:0071174)2.86668601
122DNA topological change (GO:0006265)2.85834557
123* base-excision repair (GO:0006284)2.85690174
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85074579
125regulation of double-strand break repair via homologous recombination (GO:0010569)2.84766064
126* transcription-coupled nucleotide-excision repair (GO:0006283)2.82285764

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.72747887
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.94103281
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.83241656
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55789602
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.16473614
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79127500
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54911011
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44192354
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42645977
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.31632828
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.29895734
12* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27749515
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.18871557
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18626243
15AR_21909140_ChIP-Seq_LNCAP_Human2.18084426
16XRN2_22483619_ChIP-Seq_HELA_Human2.13048400
17MYC_22102868_ChIP-Seq_BL_Human2.12981787
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10763281
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.10424383
20E2F7_22180533_ChIP-Seq_HELA_Human10.4262126
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.96436563
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95547602
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93768800
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92260279
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90948912
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89101850
27VDR_23849224_ChIP-Seq_CD4+_Human1.82684278
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76174428
29FOXP3_21729870_ChIP-Seq_TREG_Human1.74410729
30CIITA_25753668_ChIP-Seq_RAJI_Human1.71770333
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70656900
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68569343
33DCP1A_22483619_ChIP-Seq_HELA_Human1.66916329
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65235013
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64887912
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64151754
37GABP_19822575_ChIP-Seq_HepG2_Human1.57787787
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53201820
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52659470
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51771234
41TTF2_22483619_ChIP-Seq_HELA_Human1.51611921
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50684158
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50106789
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47802434
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45779745
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40385950
47KDM5A_27292631_Chip-Seq_BREAST_Human1.39633034
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38122076
49ELK1_19687146_ChIP-ChIP_HELA_Human1.37155912
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36753369
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32390764
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32121332
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30428946
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26342748
55* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26126881
56TFEB_21752829_ChIP-Seq_HELA_Human1.25721471
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25614674
58VDR_21846776_ChIP-Seq_THP-1_Human1.24025133
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20404241
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18600124
61* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17359758
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15745129
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15724015
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14265013
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13708526
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.13072985
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12818742
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11527462
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10136024
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09027781
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07252467
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06015632
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05654328
74ZNF263_19887448_ChIP-Seq_K562_Human1.05544046
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04618481
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04326202
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03839034
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01677816
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98062060
80ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97458668
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96848214
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96307655
83NANOG_21062744_ChIP-ChIP_HESCs_Human0.93578897
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92672533
85* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92135369
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90722404
87SOX17_20123909_ChIP-Seq_XEN_Mouse0.89691887
88TP63_19390658_ChIP-ChIP_HaCaT_Human0.88296012
89SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88071104
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88032988
91SRF_21415370_ChIP-Seq_HL-1_Mouse0.87815930
92CHD1_26751641_Chip-Seq_LNCaP_Human0.87584535
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86936567
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85866359
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85637834
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84711518
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84711518
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84711518
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84537053
100TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84013113
101UTX_26944678_Chip-Seq_JUKART_Human0.83558623
102TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83008605
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82889936
104SPI1_23547873_ChIP-Seq_NB4_Human0.81224219
105MYC_18940864_ChIP-ChIP_HL60_Human0.81083119
106* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80933215
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80326547
108TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80245057
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79967559
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79896309
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76133994
112TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72713716
113NCOR1_26117541_ChIP-Seq_K562_Human0.71414521
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70708940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability4.88875840
2MP0003693_abnormal_embryo_hatching4.57509040
3MP0003111_abnormal_nucleus_morphology4.48320763
4MP0004957_abnormal_blastocyst_morpholog4.21307026
5MP0003077_abnormal_cell_cycle3.99330506
6MP0008057_abnormal_DNA_replication3.96428047
7MP0008058_abnormal_DNA_repair3.09083074
8MP0010352_gastrointestinal_tract_polyps2.96484162
9MP0010307_abnormal_tumor_latency2.81863710
10MP0008007_abnormal_cellular_replicative2.73668668
11MP0001730_embryonic_growth_arrest2.65821161
12MP0008932_abnormal_embryonic_tissue2.49227196
13* MP0000350_abnormal_cell_proliferation2.39816278
14MP0005464_abnormal_platelet_physiology2.26545044
15MP0003123_paternal_imprinting2.16272889
16MP0002396_abnormal_hematopoietic_system2.13526368
17MP0008877_abnormal_DNA_methylation2.10670227
18MP0003786_premature_aging1.88380390
19MP0001697_abnormal_embryo_size1.87032428
20MP0009697_abnormal_copulation1.85176549
21MP0001672_abnormal_embryogenesis/_devel1.80979794
22MP0005380_embryogenesis_phenotype1.80979794
23* MP0002080_prenatal_lethality1.74036351
24MP0005076_abnormal_cell_differentiation1.73686421
25MP0004197_abnormal_fetal_growth/weight/1.66619180
26MP0002085_abnormal_embryonic_tissue1.65800119
27MP0003806_abnormal_nucleotide_metabolis1.63081545
28MP0003984_embryonic_growth_retardation1.63037155
29MP0003705_abnormal_hypodermis_morpholog1.62668181
30MP0002084_abnormal_developmental_patter1.61070220
31* MP0002019_abnormal_tumor_incidence1.59970070
32MP0002088_abnormal_embryonic_growth/wei1.59830323
33MP0004808_abnormal_hematopoietic_stem1.59111845
34MP0002086_abnormal_extraembryonic_tissu1.54252908
35MP0000490_abnormal_crypts_of1.52530303
36MP0003763_abnormal_thymus_physiology1.49494912
37MP0000313_abnormal_cell_death1.47409250
38MP0000703_abnormal_thymus_morphology1.41706681
39MP0008260_abnormal_autophagy1.34299746
40MP0006035_abnormal_mitochondrial_morpho1.32627202
41MP0004185_abnormal_adipocyte_glucose1.31897004
42MP0006054_spinal_hemorrhage1.30112937
43MP0010234_abnormal_vibrissa_follicle1.27346312
44MP0002398_abnormal_bone_marrow1.24722666
45MP0002210_abnormal_sex_determination1.23309259
46MP0003121_genomic_imprinting1.22544788
47MP0009333_abnormal_splenocyte_physiolog1.20390500
48MP0005023_abnormal_wound_healing1.17138033
49MP0002722_abnormal_immune_system1.16284163
50MP0003567_abnormal_fetal_cardiomyocyte1.15104433
51MP0003890_abnormal_embryonic-extraembry1.14856079
52MP0001346_abnormal_lacrimal_gland1.13724649
53MP0001145_abnormal_male_reproductive1.13046489
54MP0006036_abnormal_mitochondrial_physio1.11970263
55MP0001929_abnormal_gametogenesis1.11795338
56MP0000537_abnormal_urethra_morphology1.11450961
57MP0003566_abnormal_cell_adhesion1.11401160
58MP0000689_abnormal_spleen_morphology1.09237807
59MP0002877_abnormal_melanocyte_morpholog1.08539866
60MP0001293_anophthalmia1.06989319
61MP0001661_extended_life_span1.02154653
62MP0010030_abnormal_orbit_morphology1.00235575
63MP0005075_abnormal_melanosome_morpholog0.99543870
64MP0000358_abnormal_cell_content/0.99530607
65MP0002796_impaired_skin_barrier0.95078386
66MP0000653_abnormal_sex_gland0.93285919
67* MP0002429_abnormal_blood_cell0.90789921
68MP0005384_cellular_phenotype0.90688146
69MP0001545_abnormal_hematopoietic_system0.90103085
70MP0005397_hematopoietic_system_phenotyp0.90103085
71MP0005621_abnormal_cell_physiology0.89399699
72MP0001849_ear_inflammation0.88477793
73MP0001915_intracranial_hemorrhage0.88229335
74MP0003941_abnormal_skin_development0.87260718
75MP0000858_altered_metastatic_potential0.85969880
76MP0004233_abnormal_muscle_weight0.85624482
77MP0009672_abnormal_birth_weight0.84494805
78MP0000372_irregular_coat_pigmentation0.81456128
79MP0009278_abnormal_bone_marrow0.80685241
80MP0003656_abnormal_erythrocyte_physiolo0.79099805
81MP0002160_abnormal_reproductive_system0.79046183
82MP0002653_abnormal_ependyma_morphology0.77749325
83MP0003718_maternal_effect0.76368029
84MP0003119_abnormal_digestive_system0.76361595
85MP0000733_abnormal_muscle_development0.76161207
86* MP0000716_abnormal_immune_system0.75433871
87MP0002111_abnormal_tail_morphology0.74829255
88MP0000428_abnormal_craniofacial_morphol0.74468018
89MP0003186_abnormal_redox_activity0.73910047
90MP0009703_decreased_birth_body0.72886431
91MP0003221_abnormal_cardiomyocyte_apopto0.71751646
92MP0002092_abnormal_eye_morphology0.71649623
93MP0002009_preneoplasia0.70986567
94MP0004133_heterotaxia0.70294260
95MP0001800_abnormal_humoral_immune0.68311182
96MP0005389_reproductive_system_phenotype0.67796672
97MP0004147_increased_porphyrin_level0.66094897
98MP0005395_other_phenotype0.65895526
99MP0000477_abnormal_intestine_morphology0.65454966
100MP0002269_muscular_atrophy0.65126971
101MP0003699_abnormal_female_reproductive0.64853754
102MP0009053_abnormal_anal_canal0.63596454
103MP0005666_abnormal_adipose_tissue0.63357889
104MP0005451_abnormal_body_composition0.63010908
105MP0002405_respiratory_system_inflammati0.62375904
106MP0001727_abnormal_embryo_implantation0.61879788
107MP0000579_abnormal_nail_morphology0.61391891
108MP0008770_decreased_survivor_rate0.61232608
109MP0001119_abnormal_female_reproductive0.60826846
110MP0002925_abnormal_cardiovascular_devel0.60400266
111MP0003950_abnormal_plasma_membrane0.60225185
112MP0001216_abnormal_epidermal_layer0.59789474
113MP0003698_abnormal_male_reproductive0.58968370
114MP0005083_abnormal_biliary_tract0.58907647
115MP0002075_abnormal_coat/hair_pigmentati0.58846628
116MP0002420_abnormal_adaptive_immunity0.58296745
117MP0003453_abnormal_keratinocyte_physiol0.57685403
118MP0003937_abnormal_limbs/digits/tail_de0.57157142
119MP0003315_abnormal_perineum_morphology0.56640301
120MP0001881_abnormal_mammary_gland0.56608232
121MP0000465_gastrointestinal_hemorrhage0.56424581
122MP0001853_heart_inflammation0.55892470
123MP0001819_abnormal_immune_cell0.55536081
124MP0005623_abnormal_meninges_morphology0.55402057
125MP0002697_abnormal_eye_size0.54876577
126MP0000377_abnormal_hair_follicle0.54452261
127MP0005266_abnormal_metabolism0.53351181
128MP0003448_altered_tumor_morphology0.52798804
129MP0005501_abnormal_skin_physiology0.52560532

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.40750858
2Birth length less than 3rd percentile (HP:0003561)4.21509554
3Colon cancer (HP:0003003)3.77158332
4Selective tooth agenesis (HP:0001592)3.73752244
5Medulloblastoma (HP:0002885)3.69793406
6Increased mean platelet volume (HP:0011877)3.68569317
7Chromsome breakage (HP:0040012)3.55871143
8Reticulocytopenia (HP:0001896)3.52369404
9Abnormal platelet volume (HP:0011876)3.37424336
10Agnosia (HP:0010524)3.35061529
11Cholecystitis (HP:0001082)3.34585171
12Abnormal gallbladder physiology (HP:0012438)3.34585171
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19643029
14Abnormality of chromosome stability (HP:0003220)3.17882279
15Petechiae (HP:0000967)3.13850969
16Rhabdomyosarcoma (HP:0002859)3.13437155
17Basal cell carcinoma (HP:0002671)3.09222579
18Astrocytoma (HP:0009592)3.01742564
19Abnormality of the astrocytes (HP:0100707)3.01742564
20Breast hypoplasia (HP:0003187)2.97802916
21Increased nuchal translucency (HP:0010880)2.89277050
22Abnormality of cells of the erythroid lineage (HP:0012130)2.87144561
23Microvesicular hepatic steatosis (HP:0001414)2.85213145
24Patellar aplasia (HP:0006443)2.81839340
25Meckel diverticulum (HP:0002245)2.81550849
26Abnormality of the anterior horn cell (HP:0006802)2.80986456
27Degeneration of anterior horn cells (HP:0002398)2.80986456
28Abnormality of glycolysis (HP:0004366)2.80967431
29Progressive muscle weakness (HP:0003323)2.74927412
30Cortical dysplasia (HP:0002539)2.73156820
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.70333844
32Abnormality of the ileum (HP:0001549)2.68223933
33Absent thumb (HP:0009777)2.66966715
34Abnormal number of erythroid precursors (HP:0012131)2.63566948
35Proximal placement of thumb (HP:0009623)2.62413477
3611 pairs of ribs (HP:0000878)2.62302601
37Abnormality of the preputium (HP:0100587)2.61671609
38Missing ribs (HP:0000921)2.61169020
39Deviation of the thumb (HP:0009603)2.60952800
40Aplasia/Hypoplasia of the patella (HP:0006498)2.58324317
41Nephroblastoma (Wilms tumor) (HP:0002667)2.53871648
42Neoplasm of the pancreas (HP:0002894)2.53278375
43Oral leukoplakia (HP:0002745)2.53258357
44Duodenal stenosis (HP:0100867)2.52198084
45Small intestinal stenosis (HP:0012848)2.52198084
46Myelodysplasia (HP:0002863)2.51981482
47Menorrhagia (HP:0000132)2.50990456
48Biliary tract neoplasm (HP:0100574)2.50582557
49Abnormality of the labia minora (HP:0012880)2.50002093
50Cafe-au-lait spot (HP:0000957)2.49072066
51Increased serum pyruvate (HP:0003542)2.47740725
52Glioma (HP:0009733)2.46940305
53High pitched voice (HP:0001620)2.45474646
54Abnormality of DNA repair (HP:0003254)2.43159531
55Neoplasm of striated muscle (HP:0009728)2.42710005
56Poikiloderma (HP:0001029)2.40296168
57Progressive external ophthalmoplegia (HP:0000590)2.39991291
58Volvulus (HP:0002580)2.34895284
59Abnormality of the umbilical cord (HP:0010881)2.33968410
60Sloping forehead (HP:0000340)2.33138490
61Amaurosis fugax (HP:0100576)2.32778845
62Embryonal renal neoplasm (HP:0011794)2.32654219
63Impulsivity (HP:0100710)2.31958382
64Neoplasm of the oral cavity (HP:0100649)2.31923800
65Absent radius (HP:0003974)2.30581218
66Prolonged bleeding time (HP:0003010)2.27897582
67Adenoma sebaceum (HP:0009720)2.27749147
68Angiofibromas (HP:0010615)2.27749147
69Abnormality of the calcaneus (HP:0008364)2.26675688
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.24634594
71Short 4th metacarpal (HP:0010044)2.24634594
72Ectopic kidney (HP:0000086)2.20732631
73Entropion (HP:0000621)2.19881281
74Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19712464
75Leiomyosarcoma (HP:0100243)2.18987445
76Uterine leiomyosarcoma (HP:0002891)2.18987445
77Carpal bone hypoplasia (HP:0001498)2.18761475
78Premature graying of hair (HP:0002216)2.18442875
79Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17394880
80Atresia of the external auditory canal (HP:0000413)2.14515538
81Abnormality of the carotid arteries (HP:0005344)2.14472443
82Bone marrow hypocellularity (HP:0005528)2.14466052
83Ovarian neoplasm (HP:0100615)2.13110588
84Cutaneous melanoma (HP:0012056)2.11111893
85Neoplasm of the colon (HP:0100273)2.10874720
86Abnormal number of incisors (HP:0011064)2.10809310
87Aplasia involving forearm bones (HP:0009822)2.10224619
88Absent forearm bone (HP:0003953)2.10224619
89Abnormality of the duodenum (HP:0002246)2.09633059
90Slender long bone (HP:0003100)2.07965122
91Prominent metopic ridge (HP:0005487)2.07572641
92Squamous cell carcinoma (HP:0002860)2.06054633
93Hepatosplenomegaly (HP:0001433)2.05437844
94Aplastic anemia (HP:0001915)2.04239660
95Freckling (HP:0001480)2.03294696
96Abnormal umbilical cord blood vessels (HP:0011403)2.02525681
97Single umbilical artery (HP:0001195)2.02525681
98Abnormality of the fetal cardiovascular system (HP:0010948)2.02525681
99Spastic diplegia (HP:0001264)2.02112813
100Pancytopenia (HP:0001876)2.00925008
101Lymphoma (HP:0002665)1.98998975
102Cerebral hypomyelination (HP:0006808)1.96646802
103Cholelithiasis (HP:0001081)1.95990323
104Rough bone trabeculation (HP:0100670)1.95798158
105Tracheoesophageal fistula (HP:0002575)1.95200182
106Centrally nucleated skeletal muscle fibers (HP:0003687)1.92295266
107Supernumerary spleens (HP:0009799)1.91848084
108Shoulder girdle muscle weakness (HP:0003547)1.91425547
109Pallor (HP:0000980)1.90719364
110T lymphocytopenia (HP:0005403)1.90603533
111Neoplasm of the rectum (HP:0100743)1.90096579
112Prominent nose (HP:0000448)1.89862343
113Ragged-red muscle fibers (HP:0003200)1.89523301
114Macrocytic anemia (HP:0001972)1.89376407
115Choanal atresia (HP:0000453)1.88940196
116Multiple enchondromatosis (HP:0005701)1.88639908
117Abnormal lung lobation (HP:0002101)1.87977813
118IgM deficiency (HP:0002850)1.87667897
119Gastrointestinal carcinoma (HP:0002672)1.87440585
120Malignant gastrointestinal tract tumors (HP:0006749)1.87440585
121Microglossia (HP:0000171)1.86359064
122Intestinal polyp (HP:0005266)1.86048881
123IgA deficiency (HP:0002720)1.86008133
124Combined immunodeficiency (HP:0005387)1.85548276
125Aplasia/Hypoplasia of the sternum (HP:0006714)1.84897751
126Increased density of long bones (HP:0006392)1.84824604
127Abdominal situs inversus (HP:0003363)1.84262439
128Abnormality of abdominal situs (HP:0011620)1.84262439
129Duplicated collecting system (HP:0000081)1.84224489
130Hyperacusis (HP:0010780)1.84077190
131Atrophy/Degeneration involving motor neurons (HP:0007373)1.83148971
132Aplasia/hypoplasia of the humerus (HP:0006507)1.83107371
133Horseshoe kidney (HP:0000085)1.82503260
134Paralysis (HP:0003470)1.81256397
135Trismus (HP:0000211)1.80619011
136Abnormality of reticulocytes (HP:0004312)1.78503252
137Overlapping toe (HP:0001845)1.78320121
138Orthostatic hypotension (HP:0001278)1.77534350
139IgG deficiency (HP:0004315)1.77060846
140High anterior hairline (HP:0009890)1.76592318
141Abnormal auditory evoked potentials (HP:0006958)1.75962473
142Trigonocephaly (HP:0000243)1.73620725
143Abnormality of cochlea (HP:0000375)1.73415599
144Termporal pattern (HP:0011008)1.71390870
145Insidious onset (HP:0003587)1.71390870
146Insomnia (HP:0100785)1.70503662
147Purpura (HP:0000979)1.70466570
148Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69991237
149Absent epiphyses (HP:0010577)1.69991237
150Back pain (HP:0003418)1.69690853
151Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68101710
152Impaired platelet aggregation (HP:0003540)1.67532263
153Abnormal platelet function (HP:0011869)1.67532263
154Abnormal gallbladder morphology (HP:0012437)1.65218945
155Premature ovarian failure (HP:0008209)1.65039352
156Upper limb muscle weakness (HP:0003484)1.64663571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.83960802
2BUB13.88847517
3WEE13.70191802
4VRK23.50080831
5SMG13.01280767
6NEK22.99341616
7EEF2K2.83238860
8NEK12.71949256
9PASK2.55047075
10TTK2.38529756
11CDK122.33446063
12EIF2AK12.28327889
13TESK22.13796335
14TSSK62.00538590
15STK101.96755038
16TLK11.96043188
17PKN21.93467900
18SCYL21.92369180
19PBK1.84275839
20RPS6KB21.82865941
21PLK11.80916845
22ATR1.74851397
23MAP3K101.73076694
24ARAF1.71821172
25SRPK11.67654199
26ACVR1B1.66455394
27MAP3K81.66085210
28BRSK21.61464282
29CDK71.59729032
30MAP4K11.58173917
31AURKB1.57550078
32TAF11.47824574
33TESK11.40354150
34TGFBR11.39630414
35CDK41.38057020
36RPS6KA41.37468674
37CHEK11.33133629
38EIF2AK31.32485144
39CHEK21.27075273
40BRSK11.24089648
41VRK11.24003928
42STK41.23281405
43PLK31.22805872
44AURKA1.22352130
45NME11.20116123
46LRRK21.19401975
47MKNK11.18303616
48NME21.17818697
49TTN1.17340182
50FLT31.13709226
51PAK41.09697281
52PLK41.09302308
53TRIM281.05188743
54TRIB31.02583306
55PDK40.97089796
56PDK30.97089796
57ATM0.95609944
58DYRK30.92715091
59ALK0.91371194
60CLK10.89478560
61CDK20.88930011
62CCNB10.86170189
63CDK90.84189694
64EPHA20.83513072
65BCKDK0.83512754
66PIM10.83134247
67BRD40.82749771
68DAPK10.79362769
69SIK30.78583045
70CDK60.74537417
71GRK60.73379392
72MELK0.72893220
73EIF2AK20.69995417
74NUAK10.67630689
75MAPKAPK30.64378976
76CDK10.63825607
77MTOR0.59226043
78PAK10.58857909
79CSNK2A20.58053749
80KDR0.57673463
81TAOK20.57487807
82CDK140.57403970
83MAP2K30.57316663
84RAF10.53422531
85MKNK20.52849761
86MAP3K130.52487638
87ZAP700.52348161
88PRKCI0.51988761
89CDK180.50588061
90PAK20.50261869
91CDK11A0.50158132
92MAP3K90.49086778
93CDK150.48563059
94PRPF4B0.48206871
95ZAK0.47458011
96STK30.47427710
97CSNK2A10.46748794
98STK160.44914510
99PRKDC0.43637453
100LIMK10.43143834
101MST1R0.42538539
102PNCK0.42307583
103BTK0.41590457
104CSF1R0.41184323
105ITK0.40821845
106JAK30.40670399
107KSR20.40045726
108RPS6KA50.39227699
109CSNK1D0.38699037
110BRAF0.38534189
111PIM20.38044112
112IRAK30.34910770
113PDK20.34817446
114FGFR10.34400887
115NEK90.33828851
116PRKD30.33259994
117ILK0.33073793
118CDK80.33012321
119ICK0.32897853
120AKT20.30130161
121BMX0.30029145
122MET0.29641791
123CSNK1E0.29170551
124CSNK1G30.28872846
125MST40.28361397
126MAPK110.28012842
127PTK60.27268984
128BCR0.24825048
129MAPK140.24651748
130MARK30.24585265
131FGFR40.24432937

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.64600686
2* Mismatch repair_Homo sapiens_hsa034304.63720537
3Base excision repair_Homo sapiens_hsa034103.43076947
4One carbon pool by folate_Homo sapiens_hsa006703.17682312
5Spliceosome_Homo sapiens_hsa030403.11009868
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09063133
7RNA transport_Homo sapiens_hsa030133.05145259
8* Nucleotide excision repair_Homo sapiens_hsa034203.05085373
9Cell cycle_Homo sapiens_hsa041102.99152159
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.81450117
11* Homologous recombination_Homo sapiens_hsa034402.80747221
12Ribosome_Homo sapiens_hsa030102.47095203
13Non-homologous end-joining_Homo sapiens_hsa034502.36788190
14Proteasome_Homo sapiens_hsa030502.25154097
15* Fanconi anemia pathway_Homo sapiens_hsa034602.17251907
16RNA polymerase_Homo sapiens_hsa030202.10807900
17Pyrimidine metabolism_Homo sapiens_hsa002402.03433338
18mRNA surveillance pathway_Homo sapiens_hsa030151.87196697
19RNA degradation_Homo sapiens_hsa030181.72116437
20Systemic lupus erythematosus_Homo sapiens_hsa053221.64334290
21p53 signaling pathway_Homo sapiens_hsa041151.61545358
22Fatty acid elongation_Homo sapiens_hsa000621.56866413
23Basal transcription factors_Homo sapiens_hsa030221.54470439
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35173217
25Viral carcinogenesis_Homo sapiens_hsa052031.33508038
26Antigen processing and presentation_Homo sapiens_hsa046121.24058132
27Oocyte meiosis_Homo sapiens_hsa041141.16367091
28Biosynthesis of amino acids_Homo sapiens_hsa012301.14780379
29Epstein-Barr virus infection_Homo sapiens_hsa051691.12550124
30Primary immunodeficiency_Homo sapiens_hsa053401.09337914
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07965374
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06506210
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04325376
34Purine metabolism_Homo sapiens_hsa002301.00412153
35HTLV-I infection_Homo sapiens_hsa051660.99112826
36Selenocompound metabolism_Homo sapiens_hsa004500.98683479
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.93240535
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92708345
39Pentose phosphate pathway_Homo sapiens_hsa000300.89400760
40Herpes simplex infection_Homo sapiens_hsa051680.81278598
41MicroRNAs in cancer_Homo sapiens_hsa052060.80180564
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77446294
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.75657569
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75608733
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74845220
46Carbon metabolism_Homo sapiens_hsa012000.72984110
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71870937
48Galactose metabolism_Homo sapiens_hsa000520.71720795
49Small cell lung cancer_Homo sapiens_hsa052220.70614635
50Alcoholism_Homo sapiens_hsa050340.69334866
51Steroid biosynthesis_Homo sapiens_hsa001000.68927591
52Thyroid cancer_Homo sapiens_hsa052160.65012790
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62645920
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61752646
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.59109522
56Colorectal cancer_Homo sapiens_hsa052100.58880682
57Chronic myeloid leukemia_Homo sapiens_hsa052200.58333666
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58093535
59Viral myocarditis_Homo sapiens_hsa054160.53283491
60Legionellosis_Homo sapiens_hsa051340.52954881
61Apoptosis_Homo sapiens_hsa042100.51201495
62Propanoate metabolism_Homo sapiens_hsa006400.49207449
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47647410
64mTOR signaling pathway_Homo sapiens_hsa041500.47564101
65Bladder cancer_Homo sapiens_hsa052190.47124106
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46527717
67Hepatitis B_Homo sapiens_hsa051610.46006493
68Shigellosis_Homo sapiens_hsa051310.44837301
69N-Glycan biosynthesis_Homo sapiens_hsa005100.44475530
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.43313084
71Measles_Homo sapiens_hsa051620.43010874
72Hippo signaling pathway_Homo sapiens_hsa043900.42972002
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41852492
74HIF-1 signaling pathway_Homo sapiens_hsa040660.39567587
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38716018
76Non-small cell lung cancer_Homo sapiens_hsa052230.38032273
77Fructose and mannose metabolism_Homo sapiens_hsa000510.38002135
78Adherens junction_Homo sapiens_hsa045200.37758952
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37667712
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37007027
81Arginine and proline metabolism_Homo sapiens_hsa003300.36926037
82Fatty acid metabolism_Homo sapiens_hsa012120.36879021
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35070249
84T cell receptor signaling pathway_Homo sapiens_hsa046600.34087104
85Huntingtons disease_Homo sapiens_hsa050160.33086500
86Lysine degradation_Homo sapiens_hsa003100.32792590
87TGF-beta signaling pathway_Homo sapiens_hsa043500.32717458
88Platelet activation_Homo sapiens_hsa046110.31466678
89B cell receptor signaling pathway_Homo sapiens_hsa046620.30610177
90Notch signaling pathway_Homo sapiens_hsa043300.30400527
91Basal cell carcinoma_Homo sapiens_hsa052170.29572437
92Prostate cancer_Homo sapiens_hsa052150.29104488
93Parkinsons disease_Homo sapiens_hsa050120.28834597
94Pancreatic cancer_Homo sapiens_hsa052120.28438556
95Acute myeloid leukemia_Homo sapiens_hsa052210.28225431
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.28100387
97Folate biosynthesis_Homo sapiens_hsa007900.27865849
98Pathways in cancer_Homo sapiens_hsa052000.26908412
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26148424
100Vitamin B6 metabolism_Homo sapiens_hsa007500.26040928
101Sulfur relay system_Homo sapiens_hsa041220.25697213
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25520728
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.24441594
104Proteoglycans in cancer_Homo sapiens_hsa052050.23326195
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23321741
106Glutathione metabolism_Homo sapiens_hsa004800.21298203
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20895161
108Hematopoietic cell lineage_Homo sapiens_hsa046400.20163659
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19660334
110Metabolic pathways_Homo sapiens_hsa011000.18395792
111Protein export_Homo sapiens_hsa030600.18385335
112Tight junction_Homo sapiens_hsa045300.16592917
113Pyruvate metabolism_Homo sapiens_hsa006200.15812471
114Glioma_Homo sapiens_hsa052140.15805266
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15247132
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15068153
117Wnt signaling pathway_Homo sapiens_hsa043100.14624377
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.14107071
119Influenza A_Homo sapiens_hsa051640.14028965
120Endometrial cancer_Homo sapiens_hsa052130.13674264
121Melanoma_Homo sapiens_hsa052180.13186079
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12669919
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12259389
124VEGF signaling pathway_Homo sapiens_hsa043700.11938658

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