

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proline biosynthetic process (GO:0006561) | 6.55055356 |
| 2 | DNA deamination (GO:0045006) | 6.47826037 |
| 3 | replication fork processing (GO:0031297) | 5.93934936 |
| 4 | transcription from mitochondrial promoter (GO:0006390) | 5.60882986 |
| 5 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 5.51820185 |
| 6 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 5.22808542 |
| 7 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 5.22808542 |
| 8 | * telomere maintenance via semi-conservative replication (GO:0032201) | 5.13436999 |
| 9 | * DNA strand elongation involved in DNA replication (GO:0006271) | 5.13155897 |
| 10 | * DNA strand elongation (GO:0022616) | 4.85744388 |
| 11 | formation of translation preinitiation complex (GO:0001731) | 4.82477501 |
| 12 | proline metabolic process (GO:0006560) | 4.81967064 |
| 13 | viral mRNA export from host cell nucleus (GO:0046784) | 4.76160466 |
| 14 | embryonic process involved in female pregnancy (GO:0060136) | 4.57544100 |
| 15 | DNA strand renaturation (GO:0000733) | 4.46168869 |
| 16 | DNA replication initiation (GO:0006270) | 4.43213102 |
| 17 | * telomere maintenance via recombination (GO:0000722) | 4.37913188 |
| 18 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.30993133 |
| 19 | mitochondrial DNA metabolic process (GO:0032042) | 4.29469029 |
| 20 | chromatin remodeling at centromere (GO:0031055) | 4.19476889 |
| 21 | CENP-A containing nucleosome assembly (GO:0034080) | 4.17480088 |
| 22 | DNA unwinding involved in DNA replication (GO:0006268) | 4.07528840 |
| 23 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.07342739 |
| 24 | kinetochore assembly (GO:0051382) | 4.06528520 |
| 25 | meiotic chromosome segregation (GO:0045132) | 4.06351010 |
| 26 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 4.05376433 |
| 27 | * nucleotide-excision repair, DNA gap filling (GO:0006297) | 4.02588535 |
| 28 | * mitotic recombination (GO:0006312) | 4.00591183 |
| 29 | positive regulation of protein homooligomerization (GO:0032464) | 3.99497555 |
| 30 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.99246793 |
| 31 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.94825646 |
| 32 | DNA replication checkpoint (GO:0000076) | 3.91827723 |
| 33 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.90957544 |
| 34 | negative regulation of ligase activity (GO:0051352) | 3.90714736 |
| 35 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.90714736 |
| 36 | kinetochore organization (GO:0051383) | 3.88727967 |
| 37 | * telomere maintenance via telomere lengthening (GO:0010833) | 3.82913438 |
| 38 | oxidative demethylation (GO:0070989) | 3.75049346 |
| 39 | termination of RNA polymerase II transcription (GO:0006369) | 3.74028817 |
| 40 | * base-excision repair (GO:0006284) | 3.73206352 |
| 41 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.70839054 |
| 42 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.68227990 |
| 43 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.68227990 |
| 44 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.68227990 |
| 45 | establishment of integrated proviral latency (GO:0075713) | 3.67311840 |
| 46 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.67051291 |
| 47 | DNA double-strand break processing (GO:0000729) | 3.65106685 |
| 48 | histone exchange (GO:0043486) | 3.64551693 |
| 49 | maturation of 5.8S rRNA (GO:0000460) | 3.63909267 |
| 50 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.63098557 |
| 51 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.63098557 |
| 52 | mRNA cleavage (GO:0006379) | 3.60514959 |
| 53 | establishment of apical/basal cell polarity (GO:0035089) | 3.60178969 |
| 54 | protein K6-linked ubiquitination (GO:0085020) | 3.60112909 |
| 55 | negative regulation of mRNA processing (GO:0050686) | 3.58707889 |
| 56 | poly(A)+ mRNA export from nucleus (GO:0016973) | 3.56809351 |
| 57 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.56242550 |
| 58 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.56242550 |
| 59 | non-recombinational repair (GO:0000726) | 3.54740201 |
| 60 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.54740201 |
| 61 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.53612410 |
| 62 | ATP synthesis coupled proton transport (GO:0015986) | 3.53612410 |
| 63 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.53580129 |
| 64 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.52676766 |
| 65 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.52656345 |
| 66 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.51086091 |
| 67 | ribosome biogenesis (GO:0042254) | 3.50389211 |
| 68 | DNA topological change (GO:0006265) | 3.47866327 |
| 69 | DNA ligation (GO:0006266) | 3.47860978 |
| 70 | mitotic sister chromatid segregation (GO:0000070) | 3.47135397 |
| 71 | negative regulation of RNA splicing (GO:0033119) | 3.44936793 |
| 72 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.44709027 |
| 73 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.44709027 |
| 74 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.44709027 |
| 75 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.43874969 |
| 76 | mitochondrial RNA metabolic process (GO:0000959) | 3.43125931 |
| 77 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.41480005 |
| 78 | spliceosomal complex assembly (GO:0000245) | 3.39580599 |
| 79 | positive regulation of chromosome segregation (GO:0051984) | 3.39553883 |
| 80 | base-excision repair, AP site formation (GO:0006285) | 3.38478200 |
| 81 | mitotic chromosome condensation (GO:0007076) | 3.37550772 |
| 82 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.37107267 |
| 83 | positive regulation of ligase activity (GO:0051351) | 3.36533723 |
| 84 | dosage compensation (GO:0007549) | 3.36366516 |
| 85 | lactate metabolic process (GO:0006089) | 3.36344773 |
| 86 | regulation of translational fidelity (GO:0006450) | 3.35554795 |
| 87 | histone mRNA metabolic process (GO:0008334) | 3.34383047 |
| 88 | regulation of sister chromatid cohesion (GO:0007063) | 3.32813999 |
| 89 | regulation of integrin activation (GO:0033623) | 3.32771066 |
| 90 | mitotic nuclear envelope disassembly (GO:0007077) | 3.32377213 |
| 91 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.32345086 |
| 92 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.31668091 |
| 93 | nucleobase biosynthetic process (GO:0046112) | 3.29460486 |
| 94 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.28069561 |
| 95 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.27322523 |
| 96 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.27322523 |
| 97 | DNA integration (GO:0015074) | 3.25509900 |
| 98 | spliceosomal snRNP assembly (GO:0000387) | 3.24115113 |
| 99 | regulation of protein homooligomerization (GO:0032462) | 3.22619965 |
| 100 | pseudouridine synthesis (GO:0001522) | 3.22258469 |
| 101 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.21561778 |
| 102 | DNA replication-independent nucleosome organization (GO:0034724) | 3.21561778 |
| 103 | * cell cycle G1/S phase transition (GO:0044843) | 3.21321866 |
| 104 | * G1/S transition of mitotic cell cycle (GO:0000082) | 3.21321866 |
| 105 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.17424639 |
| 106 | resolution of meiotic recombination intermediates (GO:0000712) | 3.16972645 |
| 107 | protein localization to kinetochore (GO:0034501) | 3.15449433 |
| 108 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.15274027 |
| 109 | negative regulation of cell cycle arrest (GO:0071157) | 3.15126967 |
| 110 | mitochondrial DNA replication (GO:0006264) | 3.14069571 |
| 111 | rRNA processing (GO:0006364) | 3.13977055 |
| 112 | cullin deneddylation (GO:0010388) | 3.13550150 |
| 113 | oxidative phosphorylation (GO:0006119) | 3.12889047 |
| 114 | rRNA modification (GO:0000154) | 3.12214446 |
| 115 | regulation of ligase activity (GO:0051340) | 3.10367030 |
| 116 | mitotic metaphase plate congression (GO:0007080) | 3.08872410 |
| 117 | mRNA export from nucleus (GO:0006406) | 3.06161014 |
| 118 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.05626822 |
| 119 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.05626822 |
| 120 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.05499458 |
| 121 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.03927711 |
| 122 | proteasome assembly (GO:0043248) | 3.03651663 |
| 123 | nuclear envelope disassembly (GO:0051081) | 3.03545453 |
| 124 | membrane disassembly (GO:0030397) | 3.03545453 |
| 125 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.03020405 |
| 126 | establishment of monopolar cell polarity (GO:0061162) | 3.02826770 |
| 127 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 3.02826770 |
| 128 | rRNA metabolic process (GO:0016072) | 3.02585176 |
| 129 | histone H4-K12 acetylation (GO:0043983) | 3.02368712 |
| 130 | IMP biosynthetic process (GO:0006188) | 3.01495676 |
| 131 | regulation of helicase activity (GO:0051095) | 3.01417409 |
| 132 | regulation of gene silencing by RNA (GO:0060966) | 3.01335145 |
| 133 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.01335145 |
| 134 | regulation of gene silencing by miRNA (GO:0060964) | 3.01335145 |
| 135 | DNA duplex unwinding (GO:0032508) | 3.00846285 |
| 136 | DNA geometric change (GO:0032392) | 2.99584035 |
| 137 | translational initiation (GO:0006413) | 2.99420195 |
| 138 | regulation of mitochondrial translation (GO:0070129) | 2.98944636 |
| 139 | * mismatch repair (GO:0006298) | 2.98737128 |
| 140 | purine nucleobase biosynthetic process (GO:0009113) | 2.98514127 |
| 141 | establishment of viral latency (GO:0019043) | 2.96987742 |
| 142 | RNA export from nucleus (GO:0006405) | 2.96339936 |
| 143 | sister chromatid segregation (GO:0000819) | 2.95551404 |
| 144 | postreplication repair (GO:0006301) | 2.94292237 |
| 145 | negative regulation of chromosome segregation (GO:0051985) | 2.94185845 |
| 146 | maturation of SSU-rRNA (GO:0030490) | 2.93253200 |
| 147 | viral transcription (GO:0019083) | 2.92092255 |
| 148 | protein deneddylation (GO:0000338) | 2.91680697 |
| 149 | ribosome assembly (GO:0042255) | 2.90628695 |
| 150 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.89665333 |
| 151 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.89665333 |
| 152 | chaperone-mediated protein transport (GO:0072321) | 2.89571098 |
| 153 | protein complex biogenesis (GO:0070271) | 2.88783162 |
| 154 | negative regulation of mRNA metabolic process (GO:1903312) | 2.88264511 |
| 155 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.88157390 |
| 156 | isotype switching (GO:0045190) | 2.88157390 |
| 157 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.88157390 |
| 158 | * telomere maintenance (GO:0000723) | 2.87831430 |
| 159 | negative regulation of JAK-STAT cascade (GO:0046426) | 2.84722686 |
| 160 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.83877741 |
| 161 | translational termination (GO:0006415) | 2.83169344 |
| 162 | * transcription-coupled nucleotide-excision repair (GO:0006283) | 2.82486163 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.90622514 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.08803616 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.46976935 |
| 4 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.31535045 |
| 5 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.95591986 |
| 6 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.95342820 |
| 7 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.86388533 |
| 8 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.76072466 |
| 9 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.68839502 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.60996769 |
| 11 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.34994399 |
| 12 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.29005461 |
| 13 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 2.28218601 |
| 14 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.24934416 |
| 15 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.13587120 |
| 16 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.06372893 |
| 17 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.06336660 |
| 18 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.02829145 |
| 19 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.00306704 |
| 20 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.99259489 |
| 21 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.98494370 |
| 22 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.92708323 |
| 23 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.92708323 |
| 24 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.92708323 |
| 25 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.92608285 |
| 26 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.92191721 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.86207599 |
| 28 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.83982271 |
| 29 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.80576919 |
| 30 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.80255728 |
| 31 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.79439648 |
| 32 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.77512209 |
| 33 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.77489526 |
| 34 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.76902353 |
| 35 | * CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.76801584 |
| 36 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.76472785 |
| 37 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.72751205 |
| 38 | * NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.72645803 |
| 39 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.65344812 |
| 40 | MYC_22102868_ChIP-Seq_BL_Human | 1.64456169 |
| 41 | * YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.63146591 |
| 42 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.60246495 |
| 43 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.58227005 |
| 44 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.58196258 |
| 45 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.55704570 |
| 46 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.54997087 |
| 47 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.52616148 |
| 48 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.50553935 |
| 49 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.50091706 |
| 50 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.49275051 |
| 51 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.49226404 |
| 52 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.46445674 |
| 53 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.46444333 |
| 54 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.46339720 |
| 55 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.45336390 |
| 56 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.44655786 |
| 57 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.44036451 |
| 58 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.43235501 |
| 59 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.42842842 |
| 60 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.41968505 |
| 61 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.41636192 |
| 62 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.38639946 |
| 63 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.35802188 |
| 64 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.35349980 |
| 65 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.33433548 |
| 66 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.32052294 |
| 67 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.30886533 |
| 68 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.30509691 |
| 69 | * CIITA_25753668_ChIP-Seq_RAJI_Human | 1.28423599 |
| 70 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.28201814 |
| 71 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.28146515 |
| 72 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.27711185 |
| 73 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.26342135 |
| 74 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.25732773 |
| 75 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.24698417 |
| 76 | * NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.23125584 |
| 77 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.22356053 |
| 78 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.20721505 |
| 79 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.19472432 |
| 80 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.18211337 |
| 81 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.14975423 |
| 82 | * PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.14266687 |
| 83 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.12687434 |
| 84 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.12006718 |
| 85 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.11692272 |
| 86 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.11449637 |
| 87 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.09730065 |
| 88 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.08838128 |
| 89 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.07244705 |
| 90 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.06820142 |
| 91 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.06803624 |
| 92 | * NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.06793923 |
| 93 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.05706925 |
| 94 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.04953699 |
| 95 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.04038945 |
| 96 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.03701027 |
| 97 | * POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 1.02320975 |
| 98 | * CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.02313038 |
| 99 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.01687947 |
| 100 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.01123521 |
| 101 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.00493307 |
| 102 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.99035710 |
| 103 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.97688946 |
| 104 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.96644295 |
| 105 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.95838375 |
| 106 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.95146311 |
| 107 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.94588708 |
| 108 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 0.94301298 |
| 109 | SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.90215126 |
| 110 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.89011216 |
| 111 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.88631582 |
| 112 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.88402168 |
| 113 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.88382104 |
| 114 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.88355118 |
| 115 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.88037369 |
| 116 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.87925356 |
| 117 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.85625213 |
| 118 | EWS_26573619_Chip-Seq_HEK293_Human | 0.84835979 |
| 119 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.84007146 |
| 120 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.83822491 |
| 121 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.77604557 |
| 122 | * SPI1_23547873_ChIP-Seq_NB4_Human | 0.76381106 |
| 123 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.76241102 |
| 124 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.75587596 |
| 125 | MYB_26560356_Chip-Seq_TH2_Human | 0.73656250 |
| 126 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.71731331 |
| 127 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.70258380 |
| 128 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.66430451 |
| 129 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.64494461 |
| 130 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.63491991 |
| 131 | FUS_26573619_Chip-Seq_HEK293_Human | 0.60845917 |
| 132 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.60107898 |
| 133 | VDR_22108803_ChIP-Seq_LS180_Human | 0.59790609 |
| 134 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.59013520 |
| 135 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.58968028 |
| 136 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.58560661 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 6.41390021 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.51402865 |
| 3 | MP0003693_abnormal_embryo_hatching | 3.83572376 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.68633660 |
| 5 | MP0003111_abnormal_nucleus_morphology | 3.66918001 |
| 6 | MP0008058_abnormal_DNA_repair | 3.33767494 |
| 7 | MP0003077_abnormal_cell_cycle | 3.14102410 |
| 8 | MP0009278_abnormal_bone_marrow | 2.89933838 |
| 9 | MP0010030_abnormal_orbit_morphology | 2.84499726 |
| 10 | MP0008877_abnormal_DNA_methylation | 2.61643412 |
| 11 | MP0000372_irregular_coat_pigmentation | 2.55655798 |
| 12 | MP0003786_premature_aging | 2.52105823 |
| 13 | MP0008932_abnormal_embryonic_tissue | 2.49006255 |
| 14 | MP0005171_absent_coat_pigmentation | 2.36424016 |
| 15 | MP0002938_white_spotting | 2.15140596 |
| 16 | MP0008995_early_reproductive_senescence | 2.01258777 |
| 17 | MP0002009_preneoplasia | 1.99313674 |
| 18 | MP0009697_abnormal_copulation | 1.99213451 |
| 19 | MP0003890_abnormal_embryonic-extraembry | 1.97572616 |
| 20 | MP0010352_gastrointestinal_tract_polyps | 1.95549442 |
| 21 | MP0005397_hematopoietic_system_phenotyp | 1.95311844 |
| 22 | MP0001545_abnormal_hematopoietic_system | 1.95311844 |
| 23 | MP0004233_abnormal_muscle_weight | 1.93903268 |
| 24 | MP0000350_abnormal_cell_proliferation | 1.90164819 |
| 25 | MP0008007_abnormal_cellular_replicative | 1.89942217 |
| 26 | MP0006036_abnormal_mitochondrial_physio | 1.86985616 |
| 27 | MP0001730_embryonic_growth_arrest | 1.86705475 |
| 28 | MP0000490_abnormal_crypts_of | 1.86066387 |
| 29 | MP0001697_abnormal_embryo_size | 1.77697737 |
| 30 | MP0002396_abnormal_hematopoietic_system | 1.71452422 |
| 31 | MP0004133_heterotaxia | 1.65450508 |
| 32 | MP0006035_abnormal_mitochondrial_morpho | 1.64417527 |
| 33 | MP0004147_increased_porphyrin_level | 1.64378126 |
| 34 | MP0005174_abnormal_tail_pigmentation | 1.63699101 |
| 35 | MP0001293_anophthalmia | 1.60490189 |
| 36 | MP0005380_embryogenesis_phenotype | 1.59535887 |
| 37 | MP0001672_abnormal_embryogenesis/_devel | 1.59535887 |
| 38 | MP0002085_abnormal_embryonic_tissue | 1.59512475 |
| 39 | MP0008789_abnormal_olfactory_epithelium | 1.58029497 |
| 40 | MP0002084_abnormal_developmental_patter | 1.56864156 |
| 41 | MP0002086_abnormal_extraembryonic_tissu | 1.56650265 |
| 42 | MP0003567_abnormal_fetal_cardiomyocyte | 1.55831444 |
| 43 | MP0005671_abnormal_response_to | 1.52956150 |
| 44 | MP0004197_abnormal_fetal_growth/weight/ | 1.47375467 |
| 45 | MP0002019_abnormal_tumor_incidence | 1.47308030 |
| 46 | MP0003119_abnormal_digestive_system | 1.44515641 |
| 47 | MP0010307_abnormal_tumor_latency | 1.42305102 |
| 48 | MP0002080_prenatal_lethality | 1.39917030 |
| 49 | MP0003718_maternal_effect | 1.39667428 |
| 50 | MP0000566_synostosis | 1.37930824 |
| 51 | MP0002102_abnormal_ear_morphology | 1.37553111 |
| 52 | MP0005076_abnormal_cell_differentiation | 1.35315233 |
| 53 | MP0002653_abnormal_ependyma_morphology | 1.33679471 |
| 54 | MP0003186_abnormal_redox_activity | 1.32786483 |
| 55 | MP0005075_abnormal_melanosome_morpholog | 1.32737499 |
| 56 | MP0003984_embryonic_growth_retardation | 1.29882878 |
| 57 | MP0000313_abnormal_cell_death | 1.28342380 |
| 58 | MP0002088_abnormal_embryonic_growth/wei | 1.24654026 |
| 59 | MP0002095_abnormal_skin_pigmentation | 1.24079841 |
| 60 | MP0005408_hypopigmentation | 1.23421997 |
| 61 | MP0002249_abnormal_larynx_morphology | 1.22090768 |
| 62 | MP0009333_abnormal_splenocyte_physiolog | 1.20273043 |
| 63 | MP0002210_abnormal_sex_determination | 1.17739636 |
| 64 | MP0006072_abnormal_retinal_apoptosis | 1.17612938 |
| 65 | MP0001145_abnormal_male_reproductive | 1.17220344 |
| 66 | MP0000015_abnormal_ear_pigmentation | 1.14383124 |
| 67 | MP0003283_abnormal_digestive_organ | 1.09150653 |
| 68 | MP0008873_increased_physiological_sensi | 1.06693249 |
| 69 | MP0002111_abnormal_tail_morphology | 1.03009444 |
| 70 | MP0003763_abnormal_thymus_physiology | 1.02929496 |
| 71 | MP0002163_abnormal_gland_morphology | 1.02504756 |
| 72 | MP0002282_abnormal_trachea_morphology | 1.02326505 |
| 73 | MP0003123_paternal_imprinting | 1.02034100 |
| 74 | MP0001764_abnormal_homeostasis | 1.00964291 |
| 75 | MP0005394_taste/olfaction_phenotype | 1.00577520 |
| 76 | MP0005499_abnormal_olfactory_system | 1.00577520 |
| 77 | MP0001346_abnormal_lacrimal_gland | 0.98718295 |
| 78 | MP0000371_diluted_coat_color | 0.95096719 |
| 79 | MP0003453_abnormal_keratinocyte_physiol | 0.94303207 |
| 80 | MP0005645_abnormal_hypothalamus_physiol | 0.94239612 |
| 81 | MP0001929_abnormal_gametogenesis | 0.93804520 |
| 82 | MP0000653_abnormal_sex_gland | 0.92551656 |
| 83 | MP0000689_abnormal_spleen_morphology | 0.91785672 |
| 84 | MP0000703_abnormal_thymus_morphology | 0.89552136 |
| 85 | MP0005187_abnormal_penis_morphology | 0.88596892 |
| 86 | MP0003315_abnormal_perineum_morphology | 0.88499217 |
| 87 | MP0006292_abnormal_olfactory_placode | 0.88425275 |
| 88 | MP0005253_abnormal_eye_physiology | 0.85874363 |
| 89 | MP0001853_heart_inflammation | 0.85053695 |
| 90 | MP0002075_abnormal_coat/hair_pigmentati | 0.85002838 |
| 91 | MP0000470_abnormal_stomach_morphology | 0.83589126 |
| 92 | MP0002398_abnormal_bone_marrow | 0.81862503 |
| 93 | MP0009765_abnormal_xenobiotic_induced | 0.80683789 |
| 94 | MP0003121_genomic_imprinting | 0.80158093 |
| 95 | MP0000685_abnormal_immune_system | 0.80131127 |
| 96 | MP0000647_abnormal_sebaceous_gland | 0.79410752 |
| 97 | MP0002722_abnormal_immune_system | 0.79301190 |
| 98 | MP0005266_abnormal_metabolism | 0.78371532 |
| 99 | MP0001119_abnormal_female_reproductive | 0.77501470 |
| 100 | MP0002269_muscular_atrophy | 0.76922196 |
| 101 | MP0002405_respiratory_system_inflammati | 0.76407345 |
| 102 | MP0008872_abnormal_physiological_respon | 0.74192048 |
| 103 | MP0002114_abnormal_axial_skeleton | 0.72150395 |
| 104 | MP0002132_abnormal_respiratory_system | 0.72019987 |
| 105 | MP0001186_pigmentation_phenotype | 0.71764462 |
| 106 | MP0001727_abnormal_embryo_implantation | 0.71718079 |
| 107 | MP0002277_abnormal_respiratory_mucosa | 0.71198126 |
| 108 | MP0001529_abnormal_vocalization | 0.70874575 |
| 109 | MP0004808_abnormal_hematopoietic_stem | 0.70804123 |
| 110 | MP0009785_altered_susceptibility_to | 0.70612532 |
| 111 | MP0002148_abnormal_hypersensitivity_rea | 0.70445526 |
| 112 | MP0002932_abnormal_joint_morphology | 0.70300090 |
| 113 | MP0005410_abnormal_fertilization | 0.69820058 |
| 114 | MP0003698_abnormal_male_reproductive | 0.69398124 |
| 115 | MP0003787_abnormal_imprinting | 0.69341566 |
| 116 | MP0003656_abnormal_erythrocyte_physiolo | 0.68339138 |
| 117 | MP0009053_abnormal_anal_canal | 0.67775094 |
| 118 | MP0001835_abnormal_antigen_presentation | 0.67465915 |
| 119 | MP0003646_muscle_fatigue | 0.65887407 |
| 120 | MP0000477_abnormal_intestine_morphology | 0.65571716 |
| 121 | MP0003828_pulmonary_edema | 0.65409552 |
| 122 | MP0003941_abnormal_skin_development | 0.65141589 |
| 123 | MP0003806_abnormal_nucleotide_metabolis | 0.64015334 |
| 124 | MP0003755_abnormal_palate_morphology | 0.63551694 |
| 125 | MP0002420_abnormal_adaptive_immunity | 0.63272745 |
| 126 | MP0005501_abnormal_skin_physiology | 0.63173194 |
| 127 | MP0003935_abnormal_craniofacial_develop | 0.63071834 |
| 128 | MP0000716_abnormal_immune_system | 0.62646718 |
| 129 | MP0003136_yellow_coat_color | 0.61685592 |
| 130 | MP0000049_abnormal_middle_ear | 0.61653059 |
| 131 | MP0001819_abnormal_immune_cell | 0.61102033 |
| 132 | MP0002160_abnormal_reproductive_system | 0.60706296 |
| 133 | MP0001800_abnormal_humoral_immune | 0.59780980 |
| 134 | MP0005636_abnormal_mineral_homeostasis | 0.59747644 |
| 135 | MP0000579_abnormal_nail_morphology | 0.59693615 |
| 136 | MP0000432_abnormal_head_morphology | 0.59362951 |
| 137 | MP0002429_abnormal_blood_cell | 0.58997387 |
| 138 | MP0003699_abnormal_female_reproductive | 0.58356389 |
| 139 | MP0009672_abnormal_birth_weight | 0.57265341 |
| 140 | MP0001188_hyperpigmentation | 0.57212630 |
| 141 | MP0003448_altered_tumor_morphology | 0.56699890 |
| 142 | MP0003172_abnormal_lysosome_physiology | 0.56526587 |
| 143 | MP0004264_abnormal_extraembryonic_tissu | 0.55418274 |
| 144 | MP0002234_abnormal_pharynx_morphology | 0.55353838 |
| 145 | MP0005389_reproductive_system_phenotype | 0.55131188 |
| 146 | MP0003221_abnormal_cardiomyocyte_apopto | 0.55091337 |
| 147 | MP0000358_abnormal_cell_content/ | 0.55075841 |
| 148 | MP0005647_abnormal_sex_gland | 0.55041553 |
| 149 | MP0003936_abnormal_reproductive_system | 0.54777931 |
| 150 | MP0005023_abnormal_wound_healing | 0.54161110 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Facial hemangioma (HP:0000329) | 4.31330031 |
| 2 | Rib fusion (HP:0000902) | 4.30100484 |
| 3 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 4.11824028 |
| 4 | Rectovaginal fistula (HP:0000143) | 4.08938727 |
| 5 | Rectal fistula (HP:0100590) | 4.08938727 |
| 6 | Concave nail (HP:0001598) | 3.99667069 |
| 7 | Aplastic anemia (HP:0001915) | 3.90057430 |
| 8 | Patellar aplasia (HP:0006443) | 3.87103508 |
| 9 | Acute necrotizing encephalopathy (HP:0006965) | 3.86266612 |
| 10 | Absent thumb (HP:0009777) | 3.79669841 |
| 11 | Absent radius (HP:0003974) | 3.78591464 |
| 12 | Poikiloderma (HP:0001029) | 3.73353674 |
| 13 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.65518067 |
| 14 | Birth length less than 3rd percentile (HP:0003561) | 3.64452844 |
| 15 | Pustule (HP:0200039) | 3.64270391 |
| 16 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.61766420 |
| 17 | Intestinal fistula (HP:0100819) | 3.61035680 |
| 18 | Absent forearm bone (HP:0003953) | 3.55876440 |
| 19 | Aplasia involving forearm bones (HP:0009822) | 3.55876440 |
| 20 | Annular pancreas (HP:0001734) | 3.55677233 |
| 21 | Mitochondrial inheritance (HP:0001427) | 3.51953635 |
| 22 | Selective tooth agenesis (HP:0001592) | 3.51852325 |
| 23 | Acute encephalopathy (HP:0006846) | 3.48879066 |
| 24 | Vaginal fistula (HP:0004320) | 3.45753789 |
| 25 | Breast hypoplasia (HP:0003187) | 3.43211523 |
| 26 | Hepatocellular necrosis (HP:0001404) | 3.38441032 |
| 27 | Tongue fasciculations (HP:0001308) | 3.37322469 |
| 28 | Increased CSF lactate (HP:0002490) | 3.36041637 |
| 29 | Increased IgM level (HP:0003496) | 3.34442985 |
| 30 | Premature graying of hair (HP:0002216) | 3.28960846 |
| 31 | Abnormality of cochlea (HP:0000375) | 3.24289363 |
| 32 | Aplasia/hypoplasia of the humerus (HP:0006507) | 3.24173074 |
| 33 | Basal cell carcinoma (HP:0002671) | 3.23150174 |
| 34 | Progressive macrocephaly (HP:0004481) | 3.15248796 |
| 35 | Squamous cell carcinoma (HP:0002860) | 3.15242743 |
| 36 | Abnormality of the ileum (HP:0001549) | 3.06924366 |
| 37 | Hepatic necrosis (HP:0002605) | 3.04227696 |
| 38 | Short humerus (HP:0005792) | 3.01972251 |
| 39 | Muscle fibrillation (HP:0010546) | 2.98813058 |
| 40 | Duodenal stenosis (HP:0100867) | 2.96832569 |
| 41 | Small intestinal stenosis (HP:0012848) | 2.96832569 |
| 42 | Increased hepatocellular lipid droplets (HP:0006565) | 2.93582456 |
| 43 | Intestinal atresia (HP:0011100) | 2.91837451 |
| 44 | Hypochromic microcytic anemia (HP:0004840) | 2.87943884 |
| 45 | Microvesicular hepatic steatosis (HP:0001414) | 2.85027677 |
| 46 | Methylmalonic acidemia (HP:0002912) | 2.81479269 |
| 47 | Reticulocytopenia (HP:0001896) | 2.80069323 |
| 48 | Pancytopenia (HP:0001876) | 2.79970760 |
| 49 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.77434499 |
| 50 | Abnormal hemoglobin (HP:0011902) | 2.76888293 |
| 51 | Abnormality of male internal genitalia (HP:0000022) | 2.73570846 |
| 52 | Abnormal number of erythroid precursors (HP:0012131) | 2.71990611 |
| 53 | Abnormality of the labia minora (HP:0012880) | 2.69136051 |
| 54 | Abnormal number of incisors (HP:0011064) | 2.65139008 |
| 55 | Cerebral edema (HP:0002181) | 2.64082914 |
| 56 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.64010202 |
| 57 | Orthostatic hypotension (HP:0001278) | 2.63944477 |
| 58 | Ulnar bowing (HP:0003031) | 2.63849916 |
| 59 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.63334578 |
| 60 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.63334578 |
| 61 | Broad alveolar ridges (HP:0000187) | 2.62641753 |
| 62 | Abnormality of the duodenum (HP:0002246) | 2.61140835 |
| 63 | Lipid accumulation in hepatocytes (HP:0006561) | 2.61039738 |
| 64 | Increased serum lactate (HP:0002151) | 2.60547711 |
| 65 | Ependymoma (HP:0002888) | 2.60454443 |
| 66 | Triphalangeal thumb (HP:0001199) | 2.58823326 |
| 67 | Chromsome breakage (HP:0040012) | 2.58311204 |
| 68 | Hypoplasia of the radius (HP:0002984) | 2.57725004 |
| 69 | Volvulus (HP:0002580) | 2.56660706 |
| 70 | Methylmalonic aciduria (HP:0012120) | 2.53372025 |
| 71 | Alopecia of scalp (HP:0002293) | 2.52693884 |
| 72 | Increased intramyocellular lipid droplets (HP:0012240) | 2.49937575 |
| 73 | Capillary hemangiomas (HP:0005306) | 2.47485022 |
| 74 | Morphological abnormality of the inner ear (HP:0011390) | 2.44999230 |
| 75 | Vertebral hypoplasia (HP:0008417) | 2.44752627 |
| 76 | Aplasia/Hypoplasia of the vertebrae (HP:0008515) | 2.44752627 |
| 77 | 3-Methylglutaconic aciduria (HP:0003535) | 2.40930044 |
| 78 | Lactic acidosis (HP:0003128) | 2.37371251 |
| 79 | Male infertility (HP:0003251) | 2.37070643 |
| 80 | Acute lymphatic leukemia (HP:0006721) | 2.36810530 |
| 81 | Degeneration of anterior horn cells (HP:0002398) | 2.36676070 |
| 82 | Abnormality of the anterior horn cell (HP:0006802) | 2.36676070 |
| 83 | Muscle fiber atrophy (HP:0100295) | 2.36392560 |
| 84 | Medulloblastoma (HP:0002885) | 2.36318068 |
| 85 | Short thumb (HP:0009778) | 2.34921286 |
| 86 | Abnormal lung lobation (HP:0002101) | 2.34855567 |
| 87 | Rhabdomyosarcoma (HP:0002859) | 2.34822350 |
| 88 | Renal Fanconi syndrome (HP:0001994) | 2.33545575 |
| 89 | Astrocytoma (HP:0009592) | 2.31181045 |
| 90 | Abnormality of the astrocytes (HP:0100707) | 2.31181045 |
| 91 | Type I transferrin isoform profile (HP:0003642) | 2.30566562 |
| 92 | Cystic liver disease (HP:0006706) | 2.29702409 |
| 93 | Colon cancer (HP:0003003) | 2.29186023 |
| 94 | Meckel diverticulum (HP:0002245) | 2.28600467 |
| 95 | Back pain (HP:0003418) | 2.28495061 |
| 96 | Hyperglycinemia (HP:0002154) | 2.27790282 |
| 97 | Esophageal atresia (HP:0002032) | 2.26232424 |
| 98 | Abnormality of the aortic arch (HP:0012303) | 2.25708051 |
| 99 | Exercise intolerance (HP:0003546) | 2.24835189 |
| 100 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.24751420 |
| 101 | Abnormality of the preputium (HP:0100587) | 2.24100238 |
| 102 | Type 2 muscle fiber atrophy (HP:0003554) | 2.19305308 |
| 103 | Oral leukoplakia (HP:0002745) | 2.18514872 |
| 104 | Albinism (HP:0001022) | 2.18010611 |
| 105 | Agnosia (HP:0010524) | 2.16593831 |
| 106 | Exertional dyspnea (HP:0002875) | 2.16451520 |
| 107 | Congenital hip dislocation (HP:0001374) | 2.15529269 |
| 108 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.14348416 |
| 109 | Short chin (HP:0000331) | 2.14066972 |
| 110 | Cerebral hypomyelination (HP:0006808) | 2.13923502 |
| 111 | Hypochromic anemia (HP:0001931) | 2.13083738 |
| 112 | Rough bone trabeculation (HP:0100670) | 2.12724862 |
| 113 | Abnormality of chromosome stability (HP:0003220) | 2.12604211 |
| 114 | Myelodysplasia (HP:0002863) | 2.12110258 |
| 115 | Carpal bone hypoplasia (HP:0001498) | 2.11909916 |
| 116 | Neoplasm of the oral cavity (HP:0100649) | 2.11421662 |
| 117 | Anteriorly placed anus (HP:0001545) | 2.10692909 |
| 118 | Prostate neoplasm (HP:0100787) | 2.10359353 |
| 119 | Clubbing of toes (HP:0100760) | 2.09877133 |
| 120 | IgG deficiency (HP:0004315) | 2.09786564 |
| 121 | Sloping forehead (HP:0000340) | 2.09367318 |
| 122 | Combined immunodeficiency (HP:0005387) | 2.06442881 |
| 123 | Impulsivity (HP:0100710) | 2.06120988 |
| 124 | Severe combined immunodeficiency (HP:0004430) | 2.05827678 |
| 125 | Coronal craniosynostosis (HP:0004440) | 2.05348685 |
| 126 | Dysautonomia (HP:0002459) | 2.05051462 |
| 127 | Premature skin wrinkling (HP:0100678) | 2.03581216 |
| 128 | Respiratory failure (HP:0002878) | 2.02954377 |
| 129 | Glioma (HP:0009733) | 2.02156246 |
| 130 | Respiratory difficulties (HP:0002880) | 2.01349515 |
| 131 | Turricephaly (HP:0000262) | 2.01324651 |
| 132 | Bifid uvula (HP:0000193) | 2.00803724 |
| 133 | IgM deficiency (HP:0002850) | 2.00779322 |
| 134 | Increased serum pyruvate (HP:0003542) | 2.00426025 |
| 135 | Cellular immunodeficiency (HP:0005374) | 1.99746637 |
| 136 | Spinal muscular atrophy (HP:0007269) | 1.97107154 |
| 137 | Optic disc pallor (HP:0000543) | 1.96909391 |
| 138 | Abnormality of the prostate (HP:0008775) | 1.96084306 |
| 139 | IgA deficiency (HP:0002720) | 1.95777646 |
| 140 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.95728935 |
| 141 | Supernumerary spleens (HP:0009799) | 1.95702415 |
| 142 | Bone marrow hypocellularity (HP:0005528) | 1.95056018 |
| 143 | Increased muscle lipid content (HP:0009058) | 1.94677889 |
| 144 | Leukodystrophy (HP:0002415) | 1.92472315 |
| 145 | Abnormality of glycolysis (HP:0004366) | 1.90296864 |
| 146 | Alacrima (HP:0000522) | 1.90102340 |
| 147 | Hypotelorism (HP:0000601) | 1.89741510 |
| 148 | Abnormality of the carotid arteries (HP:0005344) | 1.88188162 |
| 149 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.87809609 |
| 150 | Pancreatic cysts (HP:0001737) | 1.86623043 |
| 151 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.84566189 |
| 152 | Abnormal protein glycosylation (HP:0012346) | 1.84537174 |
| 153 | Abnormal glycosylation (HP:0012345) | 1.84537174 |
| 154 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.84537174 |
| 155 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.84537174 |
| 156 | Diaphragmatic weakness (HP:0009113) | 1.84363321 |
| 157 | Gastrointestinal atresia (HP:0002589) | 1.84251715 |
| 158 | Abnormality of serum amino acid levels (HP:0003112) | 1.83328933 |
| 159 | Short 5th finger (HP:0009237) | 1.82775901 |
| 160 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.82670144 |
| 161 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.82474550 |
| 162 | Vertebral fusion (HP:0002948) | 1.82460710 |
| 163 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.82239241 |
| 164 | Horseshoe kidney (HP:0000085) | 1.82108748 |
| 165 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.81056125 |
| 166 | Neoplasm of the adrenal gland (HP:0100631) | 1.79280729 |
| 167 | Abnormality of the pons (HP:0007361) | 1.78692016 |
| 168 | Breech presentation (HP:0001623) | 1.78512972 |
| 169 | CNS demyelination (HP:0007305) | 1.75570382 |
| 170 | Abnormality of methionine metabolism (HP:0010901) | 1.72188028 |
| 171 | Cleft eyelid (HP:0000625) | 1.71719703 |
| 172 | Pancreatic fibrosis (HP:0100732) | 1.71617142 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ICK | 4.15219248 |
| 2 | VRK2 | 3.67903252 |
| 3 | WEE1 | 3.32169996 |
| 4 | DDR2 | 3.31860045 |
| 5 | MAP3K6 | 3.28992101 |
| 6 | ZAK | 3.20035524 |
| 7 | CDC7 | 3.16609185 |
| 8 | MAPK15 | 3.13490930 |
| 9 | BUB1 | 3.08879619 |
| 10 | MAP3K11 | 2.97072668 |
| 11 | CDK7 | 2.50307403 |
| 12 | PINK1 | 2.32806473 |
| 13 | MST4 | 2.30797735 |
| 14 | PIM2 | 2.25547491 |
| 15 | MATK | 2.25234516 |
| 16 | DAPK1 | 2.08746112 |
| 17 | NME1 | 1.94609282 |
| 18 | NUAK1 | 1.93364781 |
| 19 | PBK | 1.92528646 |
| 20 | YES1 | 1.91403514 |
| 21 | EIF2AK1 | 1.88588253 |
| 22 | PLK1 | 1.88216868 |
| 23 | BCKDK | 1.83424857 |
| 24 | NEK2 | 1.82866181 |
| 25 | FGR | 1.81891144 |
| 26 | TYRO3 | 1.75444533 |
| 27 | DYRK3 | 1.74722883 |
| 28 | UHMK1 | 1.73100409 |
| 29 | KDR | 1.68178198 |
| 30 | TXK | 1.64702312 |
| 31 | CHEK2 | 1.63208241 |
| 32 | PIM1 | 1.55358160 |
| 33 | ACVR1B | 1.54117734 |
| 34 | TRIM28 | 1.49994620 |
| 35 | DYRK1B | 1.46461689 |
| 36 | TLK1 | 1.45182260 |
| 37 | CSK | 1.44487535 |
| 38 | PRKD2 | 1.42585021 |
| 39 | TTK | 1.32535999 |
| 40 | BRSK2 | 1.32148512 |
| 41 | SRPK1 | 1.31563055 |
| 42 | CDK6 | 1.31235106 |
| 43 | NEK1 | 1.28013107 |
| 44 | NME2 | 1.27146375 |
| 45 | BMX | 1.26846337 |
| 46 | * ATR | 1.22203522 |
| 47 | RPS6KB2 | 1.21311359 |
| 48 | AURKB | 1.18253186 |
| 49 | TESK2 | 1.16563567 |
| 50 | MAP4K2 | 1.11213795 |
| 51 | AURKA | 1.09149143 |
| 52 | RPS6KL1 | 1.07986620 |
| 53 | RPS6KC1 | 1.07986620 |
| 54 | WNK3 | 1.05550708 |
| 55 | PDGFRA | 1.01603879 |
| 56 | MAP3K10 | 1.00075063 |
| 57 | AKT3 | 0.99587537 |
| 58 | VRK1 | 0.98528119 |
| 59 | MAPK11 | 0.98265711 |
| 60 | CDK4 | 0.97757565 |
| 61 | BRSK1 | 0.97540702 |
| 62 | CSNK1G3 | 0.97535480 |
| 63 | RPS6KA6 | 0.96912315 |
| 64 | PLK4 | 0.95995114 |
| 65 | TAOK2 | 0.95883251 |
| 66 | EIF2AK2 | 0.95169624 |
| 67 | EIF2AK3 | 0.93341340 |
| 68 | CHEK1 | 0.91338349 |
| 69 | TRPM7 | 0.88201775 |
| 70 | MKNK1 | 0.87547939 |
| 71 | MKNK2 | 0.85758721 |
| 72 | CLK1 | 0.84112433 |
| 73 | * CDK2 | 0.81565634 |
| 74 | CDK12 | 0.80904639 |
| 75 | CSNK2A1 | 0.78846326 |
| 76 | STK16 | 0.77808578 |
| 77 | LATS2 | 0.76546085 |
| 78 | CDK8 | 0.76011039 |
| 79 | CSNK1G1 | 0.75779859 |
| 80 | MAP3K8 | 0.73075077 |
| 81 | CSNK1G2 | 0.70525349 |
| 82 | TSSK6 | 0.70385300 |
| 83 | PDK2 | 0.69411151 |
| 84 | TAF1 | 0.68292774 |
| 85 | PLK2 | 0.66563885 |
| 86 | CSNK2A2 | 0.65476600 |
| 87 | ERBB3 | 0.65303821 |
| 88 | CCNB1 | 0.64974118 |
| 89 | EPHA2 | 0.62540882 |
| 90 | STK4 | 0.60636624 |
| 91 | * ATM | 0.60200953 |
| 92 | CSNK1A1L | 0.59381264 |
| 93 | TEC | 0.58139872 |
| 94 | MAP4K1 | 0.57777096 |
| 95 | GSK3A | 0.57754934 |
| 96 | BMPR2 | 0.57066045 |
| 97 | DYRK2 | 0.56715262 |
| 98 | STK10 | 0.56407183 |
| 99 | RPS6KA1 | 0.55712727 |
| 100 | AKT2 | 0.55446708 |
| 101 | CDC42BPA | 0.54321734 |
| 102 | BMPR1B | 0.54171943 |
| 103 | FLT3 | 0.53317074 |
| 104 | KSR1 | 0.52840769 |
| 105 | * CDK1 | 0.50569997 |
| 106 | PAK6 | 0.49770049 |
| 107 | RPS6KA4 | 0.49761484 |
| 108 | RAF1 | 0.49298187 |
| 109 | PLK3 | 0.48110295 |
| 110 | MTOR | 0.47737303 |
| 111 | PASK | 0.47402026 |
| 112 | LYN | 0.47257580 |
| 113 | PAK4 | 0.46900607 |
| 114 | BCR | 0.46316214 |
| 115 | IKBKB | 0.45601628 |
| 116 | RPS6KA5 | 0.44855728 |
| 117 | PAK1 | 0.43881583 |
| 118 | PRPF4B | 0.42151121 |
| 119 | MARK3 | 0.42020329 |
| 120 | RPS6KB1 | 0.39823956 |
| 121 | ALK | 0.39094600 |
| 122 | MAPKAPK5 | 0.38254640 |
| 123 | CSF1R | 0.37869706 |
| 124 | BRAF | 0.37131214 |
| 125 | * PRKDC | 0.34776616 |
| 126 | PRKCI | 0.34686245 |
| 127 | FES | 0.34637877 |
| 128 | KSR2 | 0.33983039 |
| 129 | TAOK3 | 0.33852539 |
| 130 | PAK3 | 0.32861510 |
| 131 | HIPK2 | 0.32383226 |
| 132 | SCYL2 | 0.32212080 |
| 133 | RIPK4 | 0.32038717 |
| 134 | STK3 | 0.31925321 |
| 135 | MAPKAPK3 | 0.31781652 |
| 136 | PHKG1 | 0.31467635 |
| 137 | PHKG2 | 0.31467635 |
| 138 | MINK1 | 0.31384191 |
| 139 | MAPK1 | 0.29036100 |
| 140 | MAPK3 | 0.28608241 |
| 141 | MELK | 0.27542760 |
| 142 | CSNK1E | 0.26795069 |
| 143 | IKBKE | 0.26655371 |
| 144 | * MAPK14 | 0.26615926 |
| 145 | MAP3K12 | 0.24777953 |
| 146 | PNCK | 0.20519885 |
| 147 | OXSR1 | 0.20335050 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * DNA replication_Homo sapiens_hsa03030 | 5.55411512 |
| 2 | * Mismatch repair_Homo sapiens_hsa03430 | 4.98722515 |
| 3 | Base excision repair_Homo sapiens_hsa03410 | 4.66284805 |
| 4 | Protein export_Homo sapiens_hsa03060 | 3.95846109 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.47210810 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.30017376 |
| 7 | Ribosome_Homo sapiens_hsa03010 | 2.95034526 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 2.90062036 |
| 9 | * Nucleotide excision repair_Homo sapiens_hsa03420 | 2.85249733 |
| 10 | * Homologous recombination_Homo sapiens_hsa03440 | 2.63890248 |
| 11 | Cell cycle_Homo sapiens_hsa04110 | 2.63419489 |
| 12 | Proteasome_Homo sapiens_hsa03050 | 2.52383323 |
| 13 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.43398823 |
| 14 | RNA polymerase_Homo sapiens_hsa03020 | 2.39427348 |
| 15 | * Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.18574022 |
| 16 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.15089315 |
| 17 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 2.09116097 |
| 18 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.02419402 |
| 19 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.98320210 |
| 20 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.84305670 |
| 21 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.61716710 |
| 22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.60034866 |
| 23 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.57758057 |
| 24 | Basal transcription factors_Homo sapiens_hsa03022 | 1.52567056 |
| 25 | RNA degradation_Homo sapiens_hsa03018 | 1.47234971 |
| 26 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.38661405 |
| 27 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.31466130 |
| 28 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.29069897 |
| 29 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.27469135 |
| 30 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.23463015 |
| 31 | Sulfur relay system_Homo sapiens_hsa04122 | 1.23287119 |
| 32 | Alzheimers disease_Homo sapiens_hsa05010 | 1.20635438 |
| 33 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.20121541 |
| 34 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.11455586 |
| 35 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.10759774 |
| 36 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.09175006 |
| 37 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.08782657 |
| 38 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.08272624 |
| 39 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.05259025 |
| 40 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.03946631 |
| 41 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.02113819 |
| 42 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.99140989 |
| 43 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.97754458 |
| 44 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.94839094 |
| 45 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.92297226 |
| 46 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.91809250 |
| 47 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.90340545 |
| 48 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.86191404 |
| 49 | Purine metabolism_Homo sapiens_hsa00230 | 0.84652085 |
| 50 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.82239546 |
| 51 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.81846876 |
| 52 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.81518532 |
| 53 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.78198865 |
| 54 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.78006413 |
| 55 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.73469414 |
| 56 | Shigellosis_Homo sapiens_hsa05131 | 0.72264038 |
| 57 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.71753713 |
| 58 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.71587314 |
| 59 | Bladder cancer_Homo sapiens_hsa05219 | 0.69651779 |
| 60 | Circadian rhythm_Homo sapiens_hsa04710 | 0.68311153 |
| 61 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.66512096 |
| 62 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.66341086 |
| 63 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.64209271 |
| 64 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.62884914 |
| 65 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.62699475 |
| 66 | Adherens junction_Homo sapiens_hsa04520 | 0.62035189 |
| 67 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.61828368 |
| 68 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.60642951 |
| 69 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.60088563 |
| 70 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.59096258 |
| 71 | HTLV-I infection_Homo sapiens_hsa05166 | 0.58786384 |
| 72 | Legionellosis_Homo sapiens_hsa05134 | 0.58711890 |
| 73 | Thyroid cancer_Homo sapiens_hsa05216 | 0.58553594 |
| 74 | Peroxisome_Homo sapiens_hsa04146 | 0.57745786 |
| 75 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.55678780 |
| 76 | Colorectal cancer_Homo sapiens_hsa05210 | 0.52852868 |
| 77 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.51619552 |
| 78 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.51319161 |
| 79 | Phototransduction_Homo sapiens_hsa04744 | 0.49957657 |
| 80 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.48413027 |
| 81 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.47301095 |
| 82 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.46348411 |
| 83 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.45612989 |
| 84 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.45467818 |
| 85 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.42912026 |
| 86 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.41357740 |
| 87 | Lysine degradation_Homo sapiens_hsa00310 | 0.41243210 |
| 88 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.41116197 |
| 89 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.40869108 |
| 90 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.39839567 |
| 91 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.38749928 |
| 92 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.37632515 |
| 93 | Huntingtons disease_Homo sapiens_hsa05016 | 0.37447220 |
| 94 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.37151941 |
| 95 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.37058371 |
| 96 | Galactose metabolism_Homo sapiens_hsa00052 | 0.36417887 |
| 97 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.36222027 |
| 98 | Allograft rejection_Homo sapiens_hsa05330 | 0.34310368 |
| 99 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.33456866 |
| 100 | Viral myocarditis_Homo sapiens_hsa05416 | 0.31802595 |
| 101 | Hepatitis B_Homo sapiens_hsa05161 | 0.31441415 |
| 102 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.31313970 |
| 103 | Measles_Homo sapiens_hsa05162 | 0.31035312 |
| 104 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.30778039 |
| 105 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.30615130 |
| 106 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.29525091 |
| 107 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.29166746 |
| 108 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.28765909 |
| 109 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.27628506 |
| 110 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.22969867 |
| 111 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.22637097 |
| 112 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.22514373 |
| 113 | Asthma_Homo sapiens_hsa05310 | 0.21583760 |
| 114 | Apoptosis_Homo sapiens_hsa04210 | 0.20631317 |
| 115 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.20104033 |
| 116 | Carbon metabolism_Homo sapiens_hsa01200 | 0.19368641 |
| 117 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.19044691 |
| 118 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.17927466 |
| 119 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.17539719 |
| 120 | Metabolic pathways_Homo sapiens_hsa01100 | 0.17020480 |
| 121 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.16629924 |
| 122 | Pathways in cancer_Homo sapiens_hsa05200 | 0.16627535 |
| 123 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.16285720 |
| 124 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.16216611 |
| 125 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.15898534 |
| 126 | Tight junction_Homo sapiens_hsa04530 | 0.15205644 |
| 127 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.15137256 |
| 128 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.13920933 |
| 129 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.13903528 |
| 130 | Parkinsons disease_Homo sapiens_hsa05012 | 0.13655905 |
| 131 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.12721488 |
| 132 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.12154436 |
| 133 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.11499977 |
| 134 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.11028725 |
| 135 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.10794967 |
| 136 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.10656911 |
| 137 | Prostate cancer_Homo sapiens_hsa05215 | 0.09943092 |
| 138 | Olfactory transduction_Homo sapiens_hsa04740 | 0.09323504 |
| 139 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.09179026 |
| 140 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.08924277 |
| 141 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.08766609 |
| 142 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.08402217 |

