RPA2P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron fate determination (GO:0048664)7.93023641
2DNA deamination (GO:0045006)6.25823333
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.54524489
4hepatocyte differentiation (GO:0070365)4.59195633
5regulation of cytokine production involved in inflammatory response (GO:1900015)4.57575194
6sulfate transport (GO:0008272)4.41617317
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.32124195
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.32124195
9NADH dehydrogenase complex assembly (GO:0010257)4.32124195
10resolution of meiotic recombination intermediates (GO:0000712)4.31744895
11DNA catabolic process, exonucleolytic (GO:0000738)4.21754678
12spinal cord association neuron differentiation (GO:0021527)4.21566206
13ribonucleoprotein complex disassembly (GO:0032988)4.10891526
14cytidine metabolic process (GO:0046087)4.08483887
15cytidine catabolic process (GO:0006216)4.08483887
16cytidine deamination (GO:0009972)4.08483887
17protein-cofactor linkage (GO:0018065)4.01663251
18negative regulation of cell aging (GO:0090344)4.00712573
19specification of organ identity (GO:0010092)3.95134832
20positive regulation of lamellipodium assembly (GO:0010592)3.86277885
21inner mitochondrial membrane organization (GO:0007007)3.78157995
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74883735
23chaperone-mediated protein transport (GO:0072321)3.57640964
24heart field specification (GO:0003128)3.57269511
25secondary heart field specification (GO:0003139)3.57269511
26regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.56891292
27organelle disassembly (GO:1903008)3.56854694
28DNA double-strand break processing (GO:0000729)3.50639536
29DNA demethylation (GO:0080111)3.49978503
30retinal ganglion cell axon guidance (GO:0031290)3.49956695
31receptor guanylyl cyclase signaling pathway (GO:0007168)3.45286699
32negative regulation of thymocyte apoptotic process (GO:0070244)3.43655462
33negative regulation of telomere maintenance (GO:0032205)3.42001901
34regulation of rhodopsin mediated signaling pathway (GO:0022400)3.41908283
35protein complex biogenesis (GO:0070271)3.41684951
36protein localization to cilium (GO:0061512)3.35563384
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.34320828
38pyrimidine ribonucleoside catabolic process (GO:0046133)3.33347797
39opioid receptor signaling pathway (GO:0038003)3.30711453
40respiratory electron transport chain (GO:0022904)3.28689256
41hematopoietic stem cell proliferation (GO:0071425)3.27933373
42mitochondrial respiratory chain complex assembly (GO:0033108)3.24470247
43electron transport chain (GO:0022900)3.24439066
44rhodopsin mediated signaling pathway (GO:0016056)3.23345951
45positive regulation of Notch signaling pathway (GO:0045747)3.19777579
46prenylation (GO:0097354)3.18839090
47protein prenylation (GO:0018342)3.18839090
48regulation of double-strand break repair via homologous recombination (GO:0010569)3.18279317
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.16892225
50ATP synthesis coupled proton transport (GO:0015986)3.15285870
51energy coupled proton transport, down electrochemical gradient (GO:0015985)3.15285870
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.13959609
53positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.11744467
54detection of calcium ion (GO:0005513)3.09754155
55positive regulation of lamellipodium organization (GO:1902745)3.07879228
56negative regulation of interleukin-1 beta production (GO:0032691)3.06433107
57mismatch repair (GO:0006298)3.04301065
58positive T cell selection (GO:0043368)3.02744291
59radial glial cell differentiation (GO:0060019)3.02308291
60pyrimidine nucleobase catabolic process (GO:0006208)3.00484626
61positive regulation of cell fate commitment (GO:0010455)2.94676438
62positive regulation of action potential (GO:0045760)2.94290232
63mitochondrial genome maintenance (GO:0000002)2.93717247
64DNA dealkylation (GO:0035510)2.90645228
65neuron fate specification (GO:0048665)2.88235350
66midbrain development (GO:0030901)2.88037565
67negative regulation of alpha-beta T cell differentiation (GO:0046639)2.82896810
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82034642
69behavioral response to nicotine (GO:0035095)2.81459975
70heparin metabolic process (GO:0030202)2.78013261
71heparin biosynthetic process (GO:0030210)2.78013261
72cerebral cortex radially oriented cell migration (GO:0021799)2.76958948
73cellular ketone body metabolic process (GO:0046950)2.76264799
74regulation of immunoglobulin secretion (GO:0051023)2.72672163
75platelet dense granule organization (GO:0060155)2.72487940
76intraciliary transport (GO:0042073)2.70444373
77signal peptide processing (GO:0006465)2.69765247
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69680839
79protein neddylation (GO:0045116)2.67725112
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.66580810
81inner ear receptor stereocilium organization (GO:0060122)2.66291824
82regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.62500728
83regulation of cellular amino acid metabolic process (GO:0006521)2.61291141
84cell differentiation in spinal cord (GO:0021515)2.60666702
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59900474
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59900474
87alpha-beta T cell differentiation (GO:0046632)2.58495711
88cullin deneddylation (GO:0010388)2.58478944
89cGMP biosynthetic process (GO:0006182)2.54054792
90regulation of voltage-gated calcium channel activity (GO:1901385)2.53700949
91negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.52978325
92purine nucleobase biosynthetic process (GO:0009113)2.52928294
93anterograde axon cargo transport (GO:0008089)2.50124767
94negative regulation of interleukin-12 production (GO:0032695)2.49471605
95DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.49335883
96ketone body metabolic process (GO:1902224)2.45998650
97male meiosis (GO:0007140)2.45913355
98positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.45901528
99hydrogen ion transmembrane transport (GO:1902600)2.45388811
100sequestering of actin monomers (GO:0042989)11.2566766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.30608471
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.92034067
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.74967014
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.60975476
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.38259234
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.08829461
7TAF15_26573619_Chip-Seq_HEK293_Human2.79256024
8VDR_22108803_ChIP-Seq_LS180_Human2.76344246
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.69196244
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.67154946
11IGF1R_20145208_ChIP-Seq_DFB_Human2.62762980
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.57769203
13FUS_26573619_Chip-Seq_HEK293_Human2.30057303
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27578318
15ZNF274_21170338_ChIP-Seq_K562_Hela2.22189655
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.20250578
17NFE2_27457419_Chip-Seq_LIVER_Mouse2.19833345
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15692871
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14563933
20AR_21572438_ChIP-Seq_LNCaP_Human2.12943457
21SUZ12_27294783_Chip-Seq_NPCs_Mouse2.09903435
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01411215
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97939531
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89993396
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81134679
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.79526738
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.73549447
28RNF2_27304074_Chip-Seq_NSC_Mouse1.73324101
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72499300
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68805137
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.65382218
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62153889
33VDR_23849224_ChIP-Seq_CD4+_Human1.60835388
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58309507
35P300_19829295_ChIP-Seq_ESCs_Human1.53957605
36EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53474127
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53147630
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48269365
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48232132
40MYC_18940864_ChIP-ChIP_HL60_Human1.48085914
41ER_23166858_ChIP-Seq_MCF-7_Human1.46505881
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45565816
43ELK1_19687146_ChIP-ChIP_HELA_Human1.45099837
44P300_18555785_Chip-Seq_ESCs_Mouse1.42025712
45GBX2_23144817_ChIP-Seq_PC3_Human1.42005131
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41082974
47SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39918464
48EWS_26573619_Chip-Seq_HEK293_Human1.39566336
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37828639
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.37770897
51OCT4_18555785_Chip-Seq_ESCs_Mouse1.37466942
52P53_22387025_ChIP-Seq_ESCs_Mouse1.37131213
53CRX_20693478_ChIP-Seq_RETINA_Mouse1.35510988
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34420315
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.32920422
56SMAD1_18555785_Chip-Seq_ESCs_Mouse1.29297735
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28934936
58CTCF_18555785_Chip-Seq_ESCs_Mouse1.28777831
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27511084
60ZFX_18555785_Chip-Seq_ESCs_Mouse1.26784779
61TP53_22573176_ChIP-Seq_HFKS_Human1.26154959
62STAT3_18555785_Chip-Seq_ESCs_Mouse1.25720780
63CMYC_18555785_Chip-Seq_ESCs_Mouse1.25627304
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25601630
65RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24991516
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.23762723
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.22822529
68EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22399174
69KLF4_18555785_Chip-Seq_ESCs_Mouse1.20942253
70SOX2_19829295_ChIP-Seq_ESCs_Human1.19462104
71NANOG_19829295_ChIP-Seq_ESCs_Human1.19462104
72ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17476653
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16328707
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.16328707
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16044592
76SOX2_18555785_Chip-Seq_ESCs_Mouse1.15757914
77OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14835581
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.14746375
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11861905
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09594860
81NMYC_18555785_Chip-Seq_ESCs_Mouse1.08433399
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08037027
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07977345
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07272646
85AR_25329375_ChIP-Seq_VCAP_Human1.06896595
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.06877599
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.05900470
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04279852
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03420199
90SMAD4_21799915_ChIP-Seq_A2780_Human1.03232033
91TTF2_22483619_ChIP-Seq_HELA_Human1.02794705
92RUNX2_22187159_ChIP-Seq_PCA_Human1.01444877
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01371217
94PU1_27457419_Chip-Seq_LIVER_Mouse0.97897065
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97432636
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96958709
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96397498
98JUN_21703547_ChIP-Seq_K562_Human0.96002555
99EZH2_27304074_Chip-Seq_ESCs_Mouse0.95756562
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94591394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.20751352
2MP0003136_yellow_coat_color4.19867950
3MP0003011_delayed_dark_adaptation4.05759714
4MP0002234_abnormal_pharynx_morphology3.32882945
5MP0002163_abnormal_gland_morphology3.22331079
6MP0001529_abnormal_vocalization3.10188292
7MP0002938_white_spotting2.99832333
8MP0005187_abnormal_penis_morphology2.77053549
9MP0002249_abnormal_larynx_morphology2.68002404
10MP0010030_abnormal_orbit_morphology2.56519384
11MP0005671_abnormal_response_to2.47867438
12MP0005379_endocrine/exocrine_gland_phen2.26247047
13MP0005310_abnormal_salivary_gland2.20129167
14MP0003880_abnormal_central_pattern2.15671646
15MP0004142_abnormal_muscle_tone2.12366417
16MP0000372_irregular_coat_pigmentation1.96195419
17MP0008875_abnormal_xenobiotic_pharmacok1.93569850
18MP0000579_abnormal_nail_morphology1.85820042
19MP0004742_abnormal_vestibular_system1.84977759
20MP0001501_abnormal_sleep_pattern1.78064817
21MP0005084_abnormal_gallbladder_morpholo1.73372511
22MP0009785_altered_susceptibility_to1.71782825
23MP0001486_abnormal_startle_reflex1.67933001
24MP0002272_abnormal_nervous_system1.54227838
25MP0002638_abnormal_pupillary_reflex1.50932511
26MP0006292_abnormal_olfactory_placode1.48209427
27MP0009745_abnormal_behavioral_response1.47279086
28MP0010386_abnormal_urinary_bladder1.43625071
29MP0001188_hyperpigmentation1.41191184
30MP0000647_abnormal_sebaceous_gland1.36550202
31MP0005253_abnormal_eye_physiology1.35258558
32MP0004381_abnormal_hair_follicle1.34347008
33MP0002735_abnormal_chemical_nociception1.33792975
34MP0005387_immune_system_phenotype1.33010361
35MP0001790_abnormal_immune_system1.33010361
36MP0009046_muscle_twitch1.31861293
37MP0000569_abnormal_digit_pigmentation1.30703353
38MP0002933_joint_inflammation1.21401928
39MP0001970_abnormal_pain_threshold1.19585950
40MP0002557_abnormal_social/conspecific_i1.18705112
41MP0005645_abnormal_hypothalamus_physiol1.16507367
42MP0005248_abnormal_Harderian_gland1.16262960
43MP0010155_abnormal_intestine_physiology1.15847780
44MP0002736_abnormal_nociception_after1.13963962
45MP0006276_abnormal_autonomic_nervous1.13267163
46MP0001919_abnormal_reproductive_system1.11710485
47MP0000631_abnormal_neuroendocrine_gland1.10613351
48MP0002876_abnormal_thyroid_physiology1.09648480
49MP0001984_abnormal_olfaction1.09534356
50MP0005551_abnormal_eye_electrophysiolog1.09035477
51MP0006035_abnormal_mitochondrial_morpho1.08395411
52MP0001968_abnormal_touch/_nociception1.06137811
53MP0002095_abnormal_skin_pigmentation1.03264762
54MP0002138_abnormal_hepatobiliary_system1.02090821
55MP0009697_abnormal_copulation0.98923832
56MP0003638_abnormal_response/metabolism_0.97648926
57MP0002148_abnormal_hypersensitivity_rea0.97327133
58MP0004147_increased_porphyrin_level0.96015822
59MP0005386_behavior/neurological_phenoty0.93587819
60MP0004924_abnormal_behavior0.93587819
61MP0001346_abnormal_lacrimal_gland0.92934776
62MP0008058_abnormal_DNA_repair0.92774703
63MP0005075_abnormal_melanosome_morpholog0.92564612
64MP0005535_abnormal_body_temperature0.91419924
65MP0000538_abnormal_urinary_bladder0.91047118
66MP0008873_increased_physiological_sensi0.86213575
67MP0002733_abnormal_thermal_nociception0.86039228
68MP0002067_abnormal_sensory_capabilities0.83850168
69MP0000026_abnormal_inner_ear0.83773448
70MP0002752_abnormal_somatic_nervous0.83640468
71MP0002102_abnormal_ear_morphology0.83190892
72MP0005085_abnormal_gallbladder_physiolo0.82105860
73MP0003315_abnormal_perineum_morphology0.81895940
74MP0001800_abnormal_humoral_immune0.80682999
75MP0001905_abnormal_dopamine_level0.79968949
76MP0002277_abnormal_respiratory_mucosa0.77548966
77MP0002075_abnormal_coat/hair_pigmentati0.75652548
78MP0002160_abnormal_reproductive_system0.75235222
79MP0002184_abnormal_innervation0.73708469
80MP0006072_abnormal_retinal_apoptosis0.72737897
81MP0002572_abnormal_emotion/affect_behav0.72624835
82MP0008789_abnormal_olfactory_epithelium0.72376950
83MP0002837_dystrophic_cardiac_calcinosis0.71136383
84MP0002132_abnormal_respiratory_system0.70367615
85MP0002282_abnormal_trachea_morphology0.69708951
86MP0005408_hypopigmentation0.69595847
87MP0000490_abnormal_crypts_of0.69131947
88MP0001986_abnormal_taste_sensitivity0.67253357
89MP0001873_stomach_inflammation0.66944409
90MP0008961_abnormal_basal_metabolism0.65410651
91MP0004215_abnormal_myocardial_fiber0.65243069
92MP0002063_abnormal_learning/memory/cond0.64729686
93MP0000230_abnormal_systemic_arterial0.64413205
94MP0004085_abnormal_heartbeat0.64299566
95MP0001186_pigmentation_phenotype0.64009563
96MP0002723_abnormal_immune_serum0.63988172
97MP0003938_abnormal_ear_development0.62954899
98MP0002210_abnormal_sex_determination0.62470207
99MP0005423_abnormal_somatic_nervous0.61595885
100MP0008872_abnormal_physiological_respon0.61354044

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the pons (HP:0012110)6.16639775
2Abnormality of the pons (HP:0007361)5.63837494
3Increased hepatocellular lipid droplets (HP:0006565)4.83993989
4Lipid accumulation in hepatocytes (HP:0006561)4.29499479
5Decreased central vision (HP:0007663)4.25934483
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.14562077
7Decreased activity of mitochondrial respiratory chain (HP:0008972)4.14562077
8Elevated erythrocyte sedimentation rate (HP:0003565)3.78533733
9Retrobulbar optic neuritis (HP:0100654)3.74707136
10Optic neuritis (HP:0100653)3.74707136
11Gastrointestinal infarctions (HP:0005244)3.52167048
12Renal Fanconi syndrome (HP:0001994)3.50589535
13Mitochondrial inheritance (HP:0001427)3.48947476
14Respiratory difficulties (HP:0002880)3.46964889
15Acute necrotizing encephalopathy (HP:0006965)3.45344013
16Focal motor seizures (HP:0011153)3.32417443
17Increased CSF lactate (HP:0002490)3.31367490
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.30316452
19Absent/shortened dynein arms (HP:0200106)3.30316452
20Increased intramyocellular lipid droplets (HP:0012240)3.11113881
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.10197845
22Orchitis (HP:0100796)3.09703438
23Keratoconjunctivitis sicca (HP:0001097)3.06629082
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.02677621
25Keratoconjunctivitis (HP:0001096)2.91776375
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.87035093
27Arthropathy (HP:0003040)2.84878267
28Abnormal mitochondria in muscle tissue (HP:0008316)2.84360270
29Exertional dyspnea (HP:0002875)2.84102267
30Progressive macrocephaly (HP:0004481)2.83742115
31Acute encephalopathy (HP:0006846)2.81993276
32Decreased electroretinogram (ERG) amplitude (HP:0000654)2.80071954
33Hemoptysis (HP:0002105)2.76786776
34Congenital, generalized hypertrichosis (HP:0004540)2.69770271
35Submucous cleft hard palate (HP:0000176)2.67355252
36Absent eyebrow (HP:0002223)2.63780248
37Hepatocellular necrosis (HP:0001404)2.60708748
38Inability to walk (HP:0002540)2.57786805
39Abnormal respiratory epithelium morphology (HP:0012253)2.56667818
40Abnormal respiratory motile cilium morphology (HP:0005938)2.56667818
41Myositis (HP:0100614)2.49842819
42Increased muscle lipid content (HP:0009058)2.45858901
433-Methylglutaconic aciduria (HP:0003535)2.43252465
44Abnormal lung lobation (HP:0002101)2.43243630
45Abnormal rod and cone electroretinograms (HP:0008323)2.42726795
46Progressive inability to walk (HP:0002505)2.41734625
47Hyperglycinuria (HP:0003108)2.39737262
48Peritonitis (HP:0002586)2.38988563
49Chronic sinusitis (HP:0011109)2.37845551
50Oligodactyly (HP:0012165)2.33588346
51Hepatic necrosis (HP:0002605)2.33068087
52Absence seizures (HP:0002121)2.22773855
53Increased serum lactate (HP:0002151)2.21966493
54Optic disc pallor (HP:0000543)2.21630007
55Cerebral edema (HP:0002181)2.21018251
56Acute hepatic failure (HP:0006554)2.20922687
57Type II lissencephaly (HP:0007260)2.18398040
58Recurrent cutaneous fungal infections (HP:0011370)2.18069161
59Chronic mucocutaneous candidiasis (HP:0002728)2.18069161
60Increased corneal curvature (HP:0100692)2.17607711
61Keratoconus (HP:0000563)2.17607711
62Abnormal number of erythroid precursors (HP:0012131)2.16557636
63Abnormality of serum amino acid levels (HP:0003112)2.14410787
64Gangrene (HP:0100758)2.06252452
65Abnormality of the phalanges of the hallux (HP:0010057)2.05242830
66Congenital stationary night blindness (HP:0007642)2.03224791
67Abnormality of cells of the erythroid lineage (HP:0012130)2.01565830
68Dialeptic seizures (HP:0011146)2.01553970
69Rhinitis (HP:0012384)2.00262035
70Severe combined immunodeficiency (HP:0004430)1.99820061
71Encephalitis (HP:0002383)1.99605171
72Abnormal ciliary motility (HP:0012262)1.98835640
73Septo-optic dysplasia (HP:0100842)1.98679076
74Chronic otitis media (HP:0000389)1.98210517
75Leukodystrophy (HP:0002415)1.97239659
76Hypoproteinemia (HP:0003075)1.96878811
77Concave nail (HP:0001598)1.96345119
78Glycosuria (HP:0003076)1.96170975
79Abnormality of urine glucose concentration (HP:0011016)1.96170975
80Postaxial foot polydactyly (HP:0001830)1.94446900
81Pulmonary infiltrates (HP:0002113)1.93965829
82Hyperphosphaturia (HP:0003109)1.92487079
83Nephronophthisis (HP:0000090)1.91113655
84Thyroiditis (HP:0100646)1.89853836
85Supernumerary spleens (HP:0009799)1.89363059
86Attenuation of retinal blood vessels (HP:0007843)1.87467957
87Exercise intolerance (HP:0003546)1.86923518
88Cone-rod dystrophy (HP:0000548)1.86922886
89Ulnar claw (HP:0001178)1.82030366
90Abnormal respiratory motile cilium physiology (HP:0012261)1.81798068
91Lactic acidosis (HP:0003128)1.81176066
92Chest pain (HP:0100749)1.79592023
93Abnormality of renal resorption (HP:0011038)1.78085079
94Increased serum pyruvate (HP:0003542)1.77165628
95Facial hemangioma (HP:0000329)1.75951722
96Abnormality of the aortic arch (HP:0012303)1.75583023
97Leukocytosis (HP:0001974)1.74675559
98Autoimmune thrombocytopenia (HP:0001973)1.73224224
99Fair hair (HP:0002286)1.72765409
100Renal tubular dysfunction (HP:0000124)1.71642711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK25.15332766
2AKT34.19138479
3GRK74.10830919
4TLK14.01795448
5NEK13.70267422
6RIPK43.12141907
7EIF2AK12.80383483
8TXK2.75421793
9EPHA32.45236407
10TNIK2.32998311
11TSSK62.29586967
12PNCK2.14952874
13MST41.90164066
14DYRK31.87234458
15WNK31.85253378
16BUB11.83717740
17PASK1.83227548
18SRPK11.77357180
19EIF2AK31.65230539
20TYK21.62342836
21MAPK131.49103173
22PINK11.45268602
23PLK41.44406897
24PHKG21.41356347
25PHKG11.41356347
26SGK21.29027786
27KIT1.14935623
28MAP3K31.11435708
29ZAK1.09698664
30VRK11.06825812
31ALK1.05613733
32MARK10.98282239
33TIE10.93766437
34JAK30.91511382
35DYRK20.89606261
36MAPK110.88937090
37TAOK30.88719312
38IKBKE0.87558185
39FRK0.84196979
40EPHA40.83500572
41SGK2230.82654807
42SGK4940.82654807
43ERBB30.82624135
44GRK10.80363999
45IRAK10.72137027
46BRAF0.72050778
47IKBKB0.69261670
48TAOK10.68686900
49CAMKK20.68223901
50STK38L0.67842316
51PLK30.66540253
52OXSR10.65800481
53YES10.65064447
54ADRBK10.64098595
55CAMK1G0.62221982
56MKNK20.61358249
57PRKCE0.58438567
58CAMK2A0.57224258
59STK100.56649559
60VRK20.53044186
61EPHB10.51145356
62FGFR30.50894387
63INSRR0.50777662
64MAP3K90.49153749
65PAK30.48352798
66CAMKK10.46631764
67LCK0.46175873
68TRPM70.44637559
69BCR0.43908081
70PRKCG0.41560162
71FGFR40.40902183
72EIF2AK20.40049379
73PRKCQ0.39217381
74PRKACA0.37103588
75NME20.36483246
76PLK20.36348961
77WNK40.35981674
78TGFBR20.35436296
79MAP2K60.35227078
80PIK3CG0.35073812
81MAP2K30.34189212
82CLK10.34164399
83ATR0.32633160
84PRKCZ0.32131430
85SGK30.31922951
86MKNK10.31532732
87CSNK1E0.30849131
88PRKG10.30533881
89MAP4K10.29915315
90DAPK20.28993796
91NTRK30.28236206
92WEE10.26943099
93SYK0.25172848
94MAP3K40.24970859
95OBSCN0.23572627
96CSNK2A20.23444133
97NME10.22244781
98RPS6KA50.22154488
99SIK30.21053303
100JAK20.20245586

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.83759283
2Oxidative phosphorylation_Homo sapiens_hsa001903.66733647
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.64559375
4Caffeine metabolism_Homo sapiens_hsa002323.46477393
5Parkinsons disease_Homo sapiens_hsa050123.35584728
6Protein export_Homo sapiens_hsa030603.18666810
7One carbon pool by folate_Homo sapiens_hsa006702.77900204
8Phototransduction_Homo sapiens_hsa047442.64225881
9Cardiac muscle contraction_Homo sapiens_hsa042602.28662937
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28051996
11Huntingtons disease_Homo sapiens_hsa050162.27360555
12Alzheimers disease_Homo sapiens_hsa050102.14283983
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03963679
14Ribosome_Homo sapiens_hsa030101.96195703
15Autoimmune thyroid disease_Homo sapiens_hsa053201.91748645
16Mismatch repair_Homo sapiens_hsa034301.82851162
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68618991
18Allograft rejection_Homo sapiens_hsa053301.65656770
19Homologous recombination_Homo sapiens_hsa034401.57003410
20Primary immunodeficiency_Homo sapiens_hsa053401.54778780
21Fanconi anemia pathway_Homo sapiens_hsa034601.50976661
22RNA degradation_Homo sapiens_hsa030181.48675723
23Type I diabetes mellitus_Homo sapiens_hsa049401.47993292
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.47234736
25Asthma_Homo sapiens_hsa053101.46005550
26Basal transcription factors_Homo sapiens_hsa030221.44752181
27Butanoate metabolism_Homo sapiens_hsa006501.43208008
28Olfactory transduction_Homo sapiens_hsa047401.43171304
29Graft-versus-host disease_Homo sapiens_hsa053321.41654316
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38101174
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30187498
32RNA polymerase_Homo sapiens_hsa030201.25561463
33Sulfur metabolism_Homo sapiens_hsa009201.25501767
34Nucleotide excision repair_Homo sapiens_hsa034201.22646825
35Propanoate metabolism_Homo sapiens_hsa006401.17790911
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16876427
37Hedgehog signaling pathway_Homo sapiens_hsa043401.15061031
38Rheumatoid arthritis_Homo sapiens_hsa053231.13192610
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08334779
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04972947
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02043605
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01735693
43Linoleic acid metabolism_Homo sapiens_hsa005911.00764838
44Purine metabolism_Homo sapiens_hsa002300.99406890
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89911813
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88509548
47Nitrogen metabolism_Homo sapiens_hsa009100.82010141
48Nicotine addiction_Homo sapiens_hsa050330.81740294
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75733704
50Chemical carcinogenesis_Homo sapiens_hsa052040.70536011
51Antigen processing and presentation_Homo sapiens_hsa046120.69716515
52Basal cell carcinoma_Homo sapiens_hsa052170.69120841
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67335698
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67053548
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65686514
56Pyruvate metabolism_Homo sapiens_hsa006200.64950997
57Morphine addiction_Homo sapiens_hsa050320.63407728
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.62921796
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60028493
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58644290
61Tryptophan metabolism_Homo sapiens_hsa003800.58226507
62Ether lipid metabolism_Homo sapiens_hsa005650.56752475
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56302025
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53109332
65Collecting duct acid secretion_Homo sapiens_hsa049660.52735560
66DNA replication_Homo sapiens_hsa030300.51063625
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49642621
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49604898
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48737119
70Measles_Homo sapiens_hsa051620.47556821
71Spliceosome_Homo sapiens_hsa030400.46796994
72RNA transport_Homo sapiens_hsa030130.46669152
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46457737
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.43561759
75Metabolic pathways_Homo sapiens_hsa011000.43123696
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40531184
77Base excision repair_Homo sapiens_hsa034100.38687255
78Viral myocarditis_Homo sapiens_hsa054160.38339874
79Fat digestion and absorption_Homo sapiens_hsa049750.37680454
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37536808
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.35986368
82Pyrimidine metabolism_Homo sapiens_hsa002400.33808976
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33753640
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.33152054
85Arachidonic acid metabolism_Homo sapiens_hsa005900.31369710
86Peroxisome_Homo sapiens_hsa041460.30994208
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.29658978
88Staphylococcus aureus infection_Homo sapiens_hsa051500.29393183
89Glutathione metabolism_Homo sapiens_hsa004800.28546185
90GABAergic synapse_Homo sapiens_hsa047270.28094599
91Folate biosynthesis_Homo sapiens_hsa007900.27171633
92Epstein-Barr virus infection_Homo sapiens_hsa051690.26560785
93Retinol metabolism_Homo sapiens_hsa008300.26124515
94Cholinergic synapse_Homo sapiens_hsa047250.25707199
95beta-Alanine metabolism_Homo sapiens_hsa004100.24692597
96Renin secretion_Homo sapiens_hsa049240.24279571
97Hematopoietic cell lineage_Homo sapiens_hsa046400.24193842
98Glutamatergic synapse_Homo sapiens_hsa047240.23454317
99Salivary secretion_Homo sapiens_hsa049700.22080577
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21622389

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