RPA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.86984230
2ribosomal small subunit biogenesis (GO:0042274)5.73499951
3viral transcription (GO:0019083)5.57994101
4translational termination (GO:0006415)5.42848019
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.90127252
6cotranslational protein targeting to membrane (GO:0006613)4.88637085
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.86398359
8protein targeting to ER (GO:0045047)4.80882388
9DNA deamination (GO:0045006)4.79259708
10CENP-A containing nucleosome assembly (GO:0034080)4.72987050
11maturation of SSU-rRNA (GO:0030490)4.70438612
12* telomere maintenance via semi-conservative replication (GO:0032201)4.70395174
13respiratory electron transport chain (GO:0022904)4.63409784
14translational elongation (GO:0006414)4.62692103
15* DNA strand elongation involved in DNA replication (GO:0006271)4.62088635
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.60690293
17chromatin remodeling at centromere (GO:0031055)4.59586253
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.57314966
19protein localization to endoplasmic reticulum (GO:0070972)4.55174773
20electron transport chain (GO:0022900)4.54170660
21kinetochore organization (GO:0051383)4.53452218
22* DNA strand elongation (GO:0022616)4.44131987
23ATP synthesis coupled proton transport (GO:0015986)4.39596389
24energy coupled proton transport, down electrochemical gradient (GO:0015985)4.39596389
25kinetochore assembly (GO:0051382)4.35741611
26cellular protein complex disassembly (GO:0043624)4.32717938
27* telomere maintenance via recombination (GO:0000722)4.30973996
28establishment of integrated proviral latency (GO:0075713)4.27181236
29viral life cycle (GO:0019058)4.26390277
30ribosomal large subunit biogenesis (GO:0042273)4.24380101
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.21007981
32translational initiation (GO:0006413)4.19172254
33DNA replication initiation (GO:0006270)4.11531126
34* mitotic recombination (GO:0006312)4.03034506
35DNA replication checkpoint (GO:0000076)4.02907155
36protein complex biogenesis (GO:0070271)3.99070278
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.95720577
38DNA replication-independent nucleosome organization (GO:0034724)3.93915902
39DNA replication-independent nucleosome assembly (GO:0006336)3.93915902
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.93131751
41mitochondrial respiratory chain complex assembly (GO:0033108)3.92035595
42regulation of mitochondrial translation (GO:0070129)3.91315078
43* nucleotide-excision repair, DNA gap filling (GO:0006297)3.79879740
44protein complex disassembly (GO:0043241)3.78411384
45proteasome assembly (GO:0043248)3.75024188
46translation (GO:0006412)3.74365282
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.69869496
48NADH dehydrogenase complex assembly (GO:0010257)3.69869496
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.69869496
50histone exchange (GO:0043486)3.63497255
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.62161510
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.61586392
53* telomere maintenance via telomere lengthening (GO:0010833)3.61397002
54ribonucleoprotein complex biogenesis (GO:0022613)3.59775252
55macromolecular complex disassembly (GO:0032984)3.57607721
56transcription elongation from RNA polymerase III promoter (GO:0006385)3.56901222
57termination of RNA polymerase III transcription (GO:0006386)3.56901222
58* transcription-coupled nucleotide-excision repair (GO:0006283)3.55620157
59nuclear-transcribed mRNA catabolic process (GO:0000956)3.51550301
60establishment of viral latency (GO:0019043)3.48629998
61rRNA processing (GO:0006364)3.47804390
62DNA ligation (GO:0006266)3.45260662
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.41925190
64oxidative phosphorylation (GO:0006119)3.41554382
657-methylguanosine mRNA capping (GO:0006370)3.41022164
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.40355675
67spliceosomal snRNP assembly (GO:0000387)3.39201852
687-methylguanosine RNA capping (GO:0009452)3.39091602
69RNA capping (GO:0036260)3.39091602
70positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.39002990
71purine nucleobase biosynthetic process (GO:0009113)3.38712328
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37179715
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37179715
74spliceosomal complex assembly (GO:0000245)3.36461128
75protein targeting to mitochondrion (GO:0006626)3.36371083
76negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36327990
77negative regulation of ligase activity (GO:0051352)3.36327990
78DNA unwinding involved in DNA replication (GO:0006268)3.35892106
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.35865224
80rRNA modification (GO:0000154)3.35836776
81attachment of spindle microtubules to kinetochore (GO:0008608)3.34322819
82mitotic metaphase plate congression (GO:0007080)3.33928860
83respiratory chain complex IV assembly (GO:0008535)3.33831093
84viral mRNA export from host cell nucleus (GO:0046784)3.33705924
85rRNA metabolic process (GO:0016072)3.33230577
86mRNA catabolic process (GO:0006402)3.33143608
87histone mRNA metabolic process (GO:0008334)3.33008848
88protein neddylation (GO:0045116)3.24992003
89DNA replication-dependent nucleosome organization (GO:0034723)3.24988813
90DNA replication-dependent nucleosome assembly (GO:0006335)3.24988813
91positive regulation of ligase activity (GO:0051351)3.24903875
92cullin deneddylation (GO:0010388)3.22399007
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21714508
94cytochrome complex assembly (GO:0017004)3.20434370
95protein localization to mitochondrion (GO:0070585)3.19531973
96inner mitochondrial membrane organization (GO:0007007)3.19306833
97chaperone-mediated protein transport (GO:0072321)3.17809963
98formation of translation preinitiation complex (GO:0001731)3.17765056
99establishment of protein localization to mitochondrion (GO:0072655)3.17590292
100signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16808640
101intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16808640
102establishment of protein localization to mitochondrial membrane (GO:0090151)3.15577934
103RNA catabolic process (GO:0006401)3.15575488
104transcription elongation from RNA polymerase I promoter (GO:0006362)3.14470138
105signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13769741
106signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13769741
107signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13769741
108protein deneddylation (GO:0000338)3.13129431
109ATP biosynthetic process (GO:0006754)3.13111295
110pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.11821518
111regulation of ubiquitin-protein transferase activity (GO:0051438)3.09469742
112DNA double-strand break processing (GO:0000729)3.09428917
113cellular component biogenesis (GO:0044085)3.08498529
114nucleobase biosynthetic process (GO:0046112)3.07514069
115metaphase plate congression (GO:0051310)3.07507701
116protein targeting to membrane (GO:0006612)3.07449851
117deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.07351521
118signal transduction involved in DNA damage checkpoint (GO:0072422)3.06804621
119signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06804621
120deoxyribonucleotide biosynthetic process (GO:0009263)3.05980903
121signal transduction involved in cell cycle checkpoint (GO:0072395)3.04692549
122* cell cycle G1/S phase transition (GO:0044843)3.03952339
123* G1/S transition of mitotic cell cycle (GO:0000082)3.03952339
124regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01993515
125pseudouridine synthesis (GO:0001522)3.01108750
126protein localization to kinetochore (GO:0034501)3.00079109
127regulation of cellular amino acid metabolic process (GO:0006521)2.99321565

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.07842920
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.46443712
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.31355774
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.29727839
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.86039478
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.83756118
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.81613582
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44426897
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.27135852
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.18090948
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.13930465
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.13580963
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.13387251
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.13221820
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.94890474
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89625400
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89189510
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84997863
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68760847
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61730575
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59904564
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56346129
23VDR_23849224_ChIP-Seq_CD4+_Human2.54514869
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46765206
25XRN2_22483619_ChIP-Seq_HELA_Human2.44807076
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31099623
27ELK1_19687146_ChIP-ChIP_HELA_Human2.28281539
28DCP1A_22483619_ChIP-Seq_HELA_Human2.24562762
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23982343
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21443989
31FOXP3_21729870_ChIP-Seq_TREG_Human2.18141266
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16348307
33TTF2_22483619_ChIP-Seq_HELA_Human2.07946713
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04198883
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01580422
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90571238
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89134386
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.85709885
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84937265
40AR_21909140_ChIP-Seq_LNCAP_Human1.80190520
41GABP_19822575_ChIP-Seq_HepG2_Human1.77624542
42* E2F1_21310950_ChIP-Seq_MCF-7_Human1.76399021
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.70947653
44* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70054694
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67150391
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63884294
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61728047
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61600530
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61385002
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53027200
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48568598
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46981138
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43896457
54MYC_18940864_ChIP-ChIP_HL60_Human1.43404882
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41739690
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36700020
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35120757
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29067183
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26289291
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26107578
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.24928979
62IRF1_19129219_ChIP-ChIP_H3396_Human1.23378111
63* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22399788
64* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22390704
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17467653
66CIITA_25753668_ChIP-Seq_RAJI_Human1.17086569
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13868325
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11100207
69* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08918409
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06956972
71KDM5A_27292631_Chip-Seq_BREAST_Human1.05119513
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04721985
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03941480
74VDR_22108803_ChIP-Seq_LS180_Human1.03045555
75* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02875804
76TP63_19390658_ChIP-ChIP_HaCaT_Human0.97457671
77RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96090504
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95328408
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95127110
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90930085
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88550597
82SPI1_23547873_ChIP-Seq_NB4_Human0.88320913
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86286972
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85975718
85SOX17_20123909_ChIP-Seq_XEN_Mouse0.85541874
86POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84322592
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76818373
88ZNF274_21170338_ChIP-Seq_K562_Hela0.75389721
89BP1_19119308_ChIP-ChIP_Hs578T_Human0.73130561
90FLI1_27457419_Chip-Seq_LIVER_Mouse0.72353296
91TP53_22573176_ChIP-Seq_HFKS_Human0.71275576
92ELF5_23300383_ChIP-Seq_T47D_Human0.71100779
93SOX2_16153702_ChIP-ChIP_HESCs_Human0.70094016
94* EWS_26573619_Chip-Seq_HEK293_Human0.69955257
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.68755566
96* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66958548
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.66418974
98TFEB_21752829_ChIP-Seq_HELA_Human0.65810874
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.65260188
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65205439
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.64801449
102NOTCH1_21737748_ChIP-Seq_TLL_Human0.64529091
103FUS_26573619_Chip-Seq_HEK293_Human0.64254608
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.63923502
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.63239689
106KLF4_18555785_ChIP-Seq_MESCs_Mouse0.62690343
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.62357027
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.62347039
109* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.62273359
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.60517537
111NANOG_16153702_ChIP-ChIP_HESCs_Human0.60342386
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.59939380
113SOX2_18692474_ChIP-Seq_MEFs_Mouse0.58633702
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.57957897
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.55768920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.80793747
2MP0008057_abnormal_DNA_replication4.63252762
3MP0010094_abnormal_chromosome_stability4.34772414
4MP0004957_abnormal_blastocyst_morpholog4.07449120
5MP0003077_abnormal_cell_cycle3.68509045
6MP0009379_abnormal_foot_pigmentation3.45520614
7MP0003111_abnormal_nucleus_morphology3.35919387
8MP0008058_abnormal_DNA_repair3.20439977
9MP0008007_abnormal_cellular_replicative2.95568821
10MP0008932_abnormal_embryonic_tissue2.94927146
11MP0003136_yellow_coat_color2.40722030
12MP0003786_premature_aging2.07044128
13MP0002938_white_spotting2.05366872
14MP0006292_abnormal_olfactory_placode2.02905433
15MP0000566_synostosis1.87953453
16MP0002396_abnormal_hematopoietic_system1.80075022
17MP0001529_abnormal_vocalization1.76352954
18MP0003718_maternal_effect1.75196438
19MP0002102_abnormal_ear_morphology1.70389743
20MP0003315_abnormal_perineum_morphology1.70315489
21MP0000490_abnormal_crypts_of1.68286251
22MP0003941_abnormal_skin_development1.66164732
23MP0008877_abnormal_DNA_methylation1.65325239
24MP0000350_abnormal_cell_proliferation1.62066584
25MP0002837_dystrophic_cardiac_calcinosis1.58360818
26MP0002132_abnormal_respiratory_system1.53483376
27MP0003806_abnormal_nucleotide_metabolis1.48398225
28MP0003123_paternal_imprinting1.44445825
29MP0009333_abnormal_splenocyte_physiolog1.43175312
30MP0003186_abnormal_redox_activity1.41121761
31MP0001764_abnormal_homeostasis1.40947983
32MP0005408_hypopigmentation1.38686829
33MP0001730_embryonic_growth_arrest1.37742789
34MP0003763_abnormal_thymus_physiology1.34287851
35MP0002234_abnormal_pharynx_morphology1.32018985
36MP0002095_abnormal_skin_pigmentation1.31811411
37MP0000372_irregular_coat_pigmentation1.30413076
38MP0005409_darkened_coat_color1.26581935
39MP0005084_abnormal_gallbladder_morpholo1.25255801
40MP0000313_abnormal_cell_death1.23510881
41MP0002163_abnormal_gland_morphology1.23254060
42MP0008995_early_reproductive_senescence1.19576886
43MP0005075_abnormal_melanosome_morpholog1.19265709
44MP0006054_spinal_hemorrhage1.17981151
45MP0008789_abnormal_olfactory_epithelium1.14597117
46MP0003567_abnormal_fetal_cardiomyocyte1.12275976
47MP0005174_abnormal_tail_pigmentation1.10716462
48MP0005171_absent_coat_pigmentation1.10473710
49MP0002019_abnormal_tumor_incidence1.09642607
50MP0000358_abnormal_cell_content/1.08581149
51MP0005394_taste/olfaction_phenotype1.07206519
52MP0005499_abnormal_olfactory_system1.07206519
53MP0001697_abnormal_embryo_size1.06131444
54MP0002210_abnormal_sex_determination1.05792187
55MP0005253_abnormal_eye_physiology1.05752205
56MP0001905_abnormal_dopamine_level1.04491049
57MP0002751_abnormal_autonomic_nervous1.03451545
58MP0004381_abnormal_hair_follicle1.03117766
59MP0002277_abnormal_respiratory_mucosa1.02530613
60MP0002090_abnormal_vision1.02040859
61MP0001188_hyperpigmentation1.01903602
62MP0008875_abnormal_xenobiotic_pharmacok1.00453857
63MP0004142_abnormal_muscle_tone1.00003200
64MP0001835_abnormal_antigen_presentation0.99999070
65MP0006036_abnormal_mitochondrial_physio0.99514635
66MP0003011_delayed_dark_adaptation0.99150805
67MP0002638_abnormal_pupillary_reflex0.97621079
68MP0000049_abnormal_middle_ear0.96727176
69MP0001986_abnormal_taste_sensitivity0.95992659
70MP0002160_abnormal_reproductive_system0.95149780
71MP0002398_abnormal_bone_marrow0.94768605
72MP0001485_abnormal_pinna_reflex0.93895689
73MP0002736_abnormal_nociception_after0.93363621
74MP0000631_abnormal_neuroendocrine_gland0.93255045
75MP0003938_abnormal_ear_development0.92074222
76MP0005379_endocrine/exocrine_gland_phen0.90058246
77MP0010030_abnormal_orbit_morphology0.89567129
78MP0001919_abnormal_reproductive_system0.89471879
79MP0000015_abnormal_ear_pigmentation0.89368806
80MP0000703_abnormal_thymus_morphology0.89166777
81MP0002085_abnormal_embryonic_tissue0.88851710
82MP0002080_prenatal_lethality0.88611286
83MP0003121_genomic_imprinting0.88295131
84MP0006072_abnormal_retinal_apoptosis0.87685414
85MP0003937_abnormal_limbs/digits/tail_de0.87649096
86MP0001145_abnormal_male_reproductive0.87400178
87MP0001672_abnormal_embryogenesis/_devel0.86227291
88MP0005380_embryogenesis_phenotype0.86227291
89MP0001293_anophthalmia0.85961418
90MP0002722_abnormal_immune_system0.83459731
91MP0004147_increased_porphyrin_level0.83087714
92MP0001853_heart_inflammation0.81113896
93MP0005671_abnormal_response_to0.81066251
94MP0001929_abnormal_gametogenesis0.80876474
95MP0002148_abnormal_hypersensitivity_rea0.80621662
96MP0000653_abnormal_sex_gland0.79821265
97MP0000689_abnormal_spleen_morphology0.79806658
98MP0005645_abnormal_hypothalamus_physiol0.78640219
99MP0005551_abnormal_eye_electrophysiolog0.78031677
100MP0008872_abnormal_physiological_respon0.77886943
101MP0001119_abnormal_female_reproductive0.76684092
102MP0002429_abnormal_blood_cell0.76111766
103MP0006035_abnormal_mitochondrial_morpho0.74418218
104MP0005332_abnormal_amino_acid0.74401314
105MP0003698_abnormal_male_reproductive0.73794597
106MP0004808_abnormal_hematopoietic_stem0.73604691
107MP0003890_abnormal_embryonic-extraembry0.73023040
108MP0009697_abnormal_copulation0.72532124
109MP0005389_reproductive_system_phenotype0.71217336
110MP0005451_abnormal_body_composition0.71039332
111MP0000716_abnormal_immune_system0.70530897
112MP0001727_abnormal_embryo_implantation0.70215843
113MP0005391_vision/eye_phenotype0.69575172
114MP0001984_abnormal_olfaction0.68967424
115MP0002697_abnormal_eye_size0.68541057
116MP0004133_heterotaxia0.67752100
117MP0005266_abnormal_metabolism0.67282662
118MP0002111_abnormal_tail_morphology0.66854590
119MP0002653_abnormal_ependyma_morphology0.66828597
120MP0000465_gastrointestinal_hemorrhage0.66660369
121MP0004134_abnormal_chest_morphology0.66180179
122MP0000647_abnormal_sebaceous_gland0.65903351
123MP0009046_muscle_twitch0.65619091
124MP0003984_embryonic_growth_retardation0.65433104
125MP0002233_abnormal_nose_morphology0.65155720
126MP0001346_abnormal_lacrimal_gland0.64502301
127MP0003195_calcinosis0.63673518
128MP0002420_abnormal_adaptive_immunity0.62431253
129MP0002088_abnormal_embryonic_growth/wei0.61892326
130MP0001819_abnormal_immune_cell0.61443835
131MP0001286_abnormal_eye_development0.60925658
132MP0001800_abnormal_humoral_immune0.60203839
133MP0001186_pigmentation_phenotype0.59615126

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.50228986
2Abnormal number of erythroid precursors (HP:0012131)5.16163851
3Reticulocytopenia (HP:0001896)5.08261801
4Acute necrotizing encephalopathy (HP:0006965)4.44985112
5Birth length less than 3rd percentile (HP:0003561)4.32657719
6Increased hepatocellular lipid droplets (HP:0006565)4.12183518
7Mitochondrial inheritance (HP:0001427)3.93321066
8Abnormal mitochondria in muscle tissue (HP:0008316)3.85776528
9Macrocytic anemia (HP:0001972)3.81189891
10Progressive macrocephaly (HP:0004481)3.55088087
11Lipid accumulation in hepatocytes (HP:0006561)3.55075738
12Breast hypoplasia (HP:0003187)3.49136238
13Increased CSF lactate (HP:0002490)3.47148452
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.46745519
15Pallor (HP:0000980)3.40959601
16Acute encephalopathy (HP:0006846)3.34383238
17Hepatocellular necrosis (HP:0001404)3.33897697
18Exertional dyspnea (HP:0002875)3.33494958
19Renal Fanconi syndrome (HP:0001994)3.31405874
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.21701588
21Aplastic anemia (HP:0001915)3.04816906
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.01019811
233-Methylglutaconic aciduria (HP:0003535)3.01016182
24Increased serum pyruvate (HP:0003542)2.98635085
25Abnormality of glycolysis (HP:0004366)2.98635085
26Hepatic necrosis (HP:0002605)2.92818458
27Chromsome breakage (HP:0040012)2.92301957
28Oral leukoplakia (HP:0002745)2.74594998
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73919085
30Congenital, generalized hypertrichosis (HP:0004540)2.72502586
31Increased serum lactate (HP:0002151)2.65704652
3211 pairs of ribs (HP:0000878)2.63958090
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63123889
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63123889
35Patellar aplasia (HP:0006443)2.61852254
36Respiratory difficulties (HP:0002880)2.56508683
37Colon cancer (HP:0003003)2.55398291
38Cerebral hypomyelination (HP:0006808)2.52101631
39Abnormality of the preputium (HP:0100587)2.50607113
40Aplasia/Hypoplasia of the patella (HP:0006498)2.50092609
41Type I transferrin isoform profile (HP:0003642)2.50026595
42Exercise intolerance (HP:0003546)2.49808709
43Increased intramyocellular lipid droplets (HP:0012240)2.47407496
44Premature graying of hair (HP:0002216)2.46859595
45Methylmalonic aciduria (HP:0012120)2.43496529
46Abnormality of chromosome stability (HP:0003220)2.41464764
47Abnormal lung lobation (HP:0002101)2.40041945
48Methylmalonic acidemia (HP:0002912)2.35786260
49Meckel diverticulum (HP:0002245)2.35446298
50Leukodystrophy (HP:0002415)2.33306931
51Triphalangeal thumb (HP:0001199)2.31862061
52Lethargy (HP:0001254)2.31372829
53Parakeratosis (HP:0001036)2.30433942
54Respiratory failure (HP:0002878)2.26976723
55Rough bone trabeculation (HP:0100670)2.26667985
56Abnormality of the ileum (HP:0001549)2.25924309
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.22891908
58Duplicated collecting system (HP:0000081)2.22843203
59Abnormality of methionine metabolism (HP:0010901)2.18490550
60Absent thumb (HP:0009777)2.17959100
61Cerebral edema (HP:0002181)2.15943241
62Pancreatic cysts (HP:0001737)2.14394095
63Pancreatic fibrosis (HP:0100732)2.13888198
64Abnormality of the heme biosynthetic pathway (HP:0010472)2.13557312
65Septo-optic dysplasia (HP:0100842)2.11990266
66Megaloblastic anemia (HP:0001889)2.11548400
67Abnormality of the renal collecting system (HP:0004742)2.11504045
68Abnormality of the labia minora (HP:0012880)2.10718205
69Abnormal protein glycosylation (HP:0012346)2.09050838
70Abnormal glycosylation (HP:0012345)2.09050838
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09050838
72Abnormal protein N-linked glycosylation (HP:0012347)2.09050838
73Abnormality of midbrain morphology (HP:0002418)2.07761574
74Molar tooth sign on MRI (HP:0002419)2.07761574
75Absent radius (HP:0003974)2.07682756
76Hyperglycinemia (HP:0002154)2.06571014
77Carpal bone hypoplasia (HP:0001498)2.06200889
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.02235289
79True hermaphroditism (HP:0010459)2.01403421
80Lactic acidosis (HP:0003128)2.01353837
81Horseshoe kidney (HP:0000085)2.00787138
82IgM deficiency (HP:0002850)2.00607041
83Optic disc pallor (HP:0000543)1.99277443
84Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95309320
85Bone marrow hypocellularity (HP:0005528)1.95012359
86Abnormality of renal resorption (HP:0011038)1.94887168
87Medulloblastoma (HP:0002885)1.94593199
88Myelodysplasia (HP:0002863)1.93242357
89Aplasia involving forearm bones (HP:0009822)1.92356153
90Absent forearm bone (HP:0003953)1.92356153
91CNS demyelination (HP:0007305)1.91699592
92Abnormality of the duodenum (HP:0002246)1.91528928
93Cellular immunodeficiency (HP:0005374)1.91419783
94Cleft eyelid (HP:0000625)1.90691507
95Microvesicular hepatic steatosis (HP:0001414)1.90426810
96Stenosis of the external auditory canal (HP:0000402)1.90245919
97Abnormality of the anterior horn cell (HP:0006802)1.89913389
98Degeneration of anterior horn cells (HP:0002398)1.89913389
99Abnormality of serum amino acid levels (HP:0003112)1.89653664
100Abnormal number of incisors (HP:0011064)1.89633011
101Nephroblastoma (Wilms tumor) (HP:0002667)1.89531791
102Hypoplasia of the capital femoral epiphysis (HP:0003090)1.89363216
103Patchy hypopigmentation of hair (HP:0011365)1.89087919
104Increased muscle lipid content (HP:0009058)1.88490674
105Small intestinal stenosis (HP:0012848)1.87214687
106Duodenal stenosis (HP:0100867)1.87214687
107Glycosuria (HP:0003076)1.87108915
108Abnormality of urine glucose concentration (HP:0011016)1.87108915
109Sclerocornea (HP:0000647)1.85948902
110Hypoplasia of the pons (HP:0012110)1.85233737
111Secondary amenorrhea (HP:0000869)1.84768989
112Reduced antithrombin III activity (HP:0001976)1.84114827
113Dicarboxylic aciduria (HP:0003215)1.83943302
114Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83943302
115Irregular epiphyses (HP:0010582)1.83369105
116Muscle fiber atrophy (HP:0100295)1.83308723
117Abnormality of placental membranes (HP:0011409)1.83248782
118Amniotic constriction ring (HP:0009775)1.83248782
119Type 2 muscle fiber atrophy (HP:0003554)1.82737701
120Pancytopenia (HP:0001876)1.82650655
121X-linked dominant inheritance (HP:0001423)1.82124415
122Poor head control (HP:0002421)1.81581908
123Clubbing of toes (HP:0100760)1.79860230
124Abnormality of the pons (HP:0007361)1.79307511
125Embryonal renal neoplasm (HP:0011794)1.78209105
126Depressed nasal ridge (HP:0000457)1.77185764
127Agnosia (HP:0010524)1.76757597
128Hyperphosphaturia (HP:0003109)1.76698634
129Abnormal trabecular bone morphology (HP:0100671)1.75022796
130Medial flaring of the eyebrow (HP:0010747)1.72118413
131Lymphoma (HP:0002665)1.72033431
132Sloping forehead (HP:0000340)1.70291847
133Multiple enchondromatosis (HP:0005701)1.69838500
134Supernumerary spleens (HP:0009799)1.69209044
135Selective tooth agenesis (HP:0001592)1.67641419
136Absent septum pellucidum (HP:0001331)1.66929950
137Abnormality of the carotid arteries (HP:0005344)1.66851344
138Median cleft lip (HP:0000161)1.65282797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.80297799
2BUB14.35400107
3WEE14.02941561
4STK163.93983292
5SRPK13.34650511
6CDC73.16295724
7VRK13.01823625
8EIF2AK13.00882386
9NME22.90062979
10MKNK12.38815682
11EIF2AK32.31269918
12PLK42.13533426
13TLK12.03690831
14TESK21.99779718
15PBK1.93969968
16ACVR1B1.90231569
17MKNK21.86138937
18BRSK21.78658404
19TAF11.75880639
20DYRK31.65872503
21PLK11.54339681
22CCNB11.54114861
23MST41.53836479
24TRIM281.46328892
25CDK81.43797633
26BCKDK1.41462518
27AURKB1.38453556
28TTK1.35519273
29CDK71.34731500
30PIM21.33586895
31WNK31.30401569
32NME11.27327236
33CHEK21.26978578
34NEK21.26484334
35PLK31.25800085
36DYRK21.25373034
37MAP4K21.23195852
38AURKA1.22765055
39ATR1.18112285
40MAP3K121.16591805
41EIF2AK21.08022889
42ZAK1.07337056
43BRSK11.05695348
44LIMK11.03338916
45BCR1.01225210
46PASK1.01156239
47TNIK0.99191307
48BMPR1B0.98944868
49TSSK60.95473016
50BRAF0.94483683
51CDK190.90206117
52MUSK0.86877463
53RPS6KA50.86646913
54CSNK1G20.83937193
55MAPK130.83827177
56CSNK2A10.83806974
57STK40.83170394
58RPS6KB20.81751209
59YES10.79468983
60IRAK40.79027382
61CLK10.78935060
62CHEK10.78106330
63CSNK1A1L0.78070409
64TEC0.75730663
65UHMK10.75422007
66GRK10.75237665
67CSNK2A20.74908655
68SCYL20.74009657
69BMPR20.73785569
70RPS6KA40.70698206
71STK240.66916382
72PDK20.64908405
73MAP3K80.64229911
74INSRR0.61773922
75TGFBR10.61271856
76DAPK10.60952331
77ERBB30.60607399
78ATM0.60450163
79TXK0.60161064
80KDR0.60070326
81CSNK1G30.59686088
82PLK20.56986442
83ILK0.56875904
84PAK10.56704468
85MAP2K70.54699627
86ARAF0.54187352
87OXSR10.52653893
88MYLK0.50827616
89ABL20.50556318
90PNCK0.49829619
91LRRK20.49661516
92PIM10.49147878
93DAPK30.48412991
94CDK10.47938218
95CDK20.47016692
96STK30.45514519
97MAP3K40.44548127
98KIT0.44372707
99ADRBK20.44258742
100STK100.44033265
101CDK30.43891989
102CDK40.43633028
103STK390.42343352
104LYN0.41730571
105TESK10.41179487
106OBSCN0.39676778
107MAPKAPK50.39434269
108PAK40.39116466
109BTK0.37877003
110NEK10.37451983
111CASK0.36826051
112CSNK1G10.36410482
113NUAK10.34923318
114CDK11A0.32617302
115GRK70.31819094
116MELK0.31545391
117CSNK1A10.31092668
118RAF10.31018310
119FRK0.30541894
120MAP4K10.29042903
121PRKCI0.29035256
122CDK180.27465254
123CSNK1E0.27382860
124CDK140.25773716
125CDK90.22691034
126PRKCG0.22649434

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.07452266
2* DNA replication_Homo sapiens_hsa030304.51131607
3Proteasome_Homo sapiens_hsa030504.00309691
4* Mismatch repair_Homo sapiens_hsa034303.74009004
5RNA polymerase_Homo sapiens_hsa030203.60407350
6Spliceosome_Homo sapiens_hsa030403.05357096
7* Homologous recombination_Homo sapiens_hsa034402.91087147
8Oxidative phosphorylation_Homo sapiens_hsa001902.75616426
9* Nucleotide excision repair_Homo sapiens_hsa034202.68738590
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68665319
11Parkinsons disease_Homo sapiens_hsa050122.55893218
12Pyrimidine metabolism_Homo sapiens_hsa002402.55730545
13Base excision repair_Homo sapiens_hsa034102.50734025
14Protein export_Homo sapiens_hsa030602.44283868
15Non-homologous end-joining_Homo sapiens_hsa034502.30418734
16RNA transport_Homo sapiens_hsa030132.12459963
17Cell cycle_Homo sapiens_hsa041102.12366121
18RNA degradation_Homo sapiens_hsa030182.11051768
19Huntingtons disease_Homo sapiens_hsa050162.08610391
20Basal transcription factors_Homo sapiens_hsa030222.06413887
21* Fanconi anemia pathway_Homo sapiens_hsa034602.00119850
22Alzheimers disease_Homo sapiens_hsa050101.70606982
23One carbon pool by folate_Homo sapiens_hsa006701.61714460
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44243396
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43369447
26Purine metabolism_Homo sapiens_hsa002301.40796676
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38506909
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28094862
29Propanoate metabolism_Homo sapiens_hsa006401.23096435
30Systemic lupus erythematosus_Homo sapiens_hsa053221.21345983
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20720518
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20486421
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17120689
34p53 signaling pathway_Homo sapiens_hsa041151.09408038
35Pyruvate metabolism_Homo sapiens_hsa006201.02054888
36mRNA surveillance pathway_Homo sapiens_hsa030150.97567592
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96738526
38Folate biosynthesis_Homo sapiens_hsa007900.96334071
39Glutathione metabolism_Homo sapiens_hsa004800.94267855
40Epstein-Barr virus infection_Homo sapiens_hsa051690.88799042
41Sulfur relay system_Homo sapiens_hsa041220.87515045
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86587568
43Primary immunodeficiency_Homo sapiens_hsa053400.79395142
44Fatty acid elongation_Homo sapiens_hsa000620.77842638
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76055719
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73350958
47Cardiac muscle contraction_Homo sapiens_hsa042600.70783575
48Sulfur metabolism_Homo sapiens_hsa009200.64788700
49Herpes simplex infection_Homo sapiens_hsa051680.64509027
50Allograft rejection_Homo sapiens_hsa053300.62808071
51Peroxisome_Homo sapiens_hsa041460.61652777
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61077421
53Antigen processing and presentation_Homo sapiens_hsa046120.59921072
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56976268
55Arachidonic acid metabolism_Homo sapiens_hsa005900.56973391
56Butanoate metabolism_Homo sapiens_hsa006500.56174170
57Graft-versus-host disease_Homo sapiens_hsa053320.54112370
58Oocyte meiosis_Homo sapiens_hsa041140.54023156
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52751029
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52749035
61Alcoholism_Homo sapiens_hsa050340.52445624
62Steroid biosynthesis_Homo sapiens_hsa001000.52320512
63Autoimmune thyroid disease_Homo sapiens_hsa053200.51455657
64Pentose phosphate pathway_Homo sapiens_hsa000300.50554760
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.50400326
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.50394860
67Metabolic pathways_Homo sapiens_hsa011000.49622560
68Chemical carcinogenesis_Homo sapiens_hsa052040.46101958
69Ether lipid metabolism_Homo sapiens_hsa005650.45285177
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45251100
71Viral carcinogenesis_Homo sapiens_hsa052030.45173936
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43016507
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.41736718
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41259341
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41124970
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.38485957
77Linoleic acid metabolism_Homo sapiens_hsa005910.37868830
78Regulation of autophagy_Homo sapiens_hsa041400.35842571
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.35174323
80Asthma_Homo sapiens_hsa053100.34944584
81Collecting duct acid secretion_Homo sapiens_hsa049660.33746460
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33032699
83N-Glycan biosynthesis_Homo sapiens_hsa005100.32802549
84Fatty acid degradation_Homo sapiens_hsa000710.32526117
85Tryptophan metabolism_Homo sapiens_hsa003800.32157209
86Retinol metabolism_Homo sapiens_hsa008300.31315971
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30101584
88Tyrosine metabolism_Homo sapiens_hsa003500.29814131
89HTLV-I infection_Homo sapiens_hsa051660.29487520
90Vitamin digestion and absorption_Homo sapiens_hsa049770.26977157
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25177038
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24804931
93beta-Alanine metabolism_Homo sapiens_hsa004100.24723490
94Hematopoietic cell lineage_Homo sapiens_hsa046400.24589037
95Vitamin B6 metabolism_Homo sapiens_hsa007500.22766602
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22146331
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21740467
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.21328973
99Caffeine metabolism_Homo sapiens_hsa002320.20300303
100Fatty acid metabolism_Homo sapiens_hsa012120.19871986
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.19690906
102Basal cell carcinoma_Homo sapiens_hsa052170.17836736
103Sphingolipid metabolism_Homo sapiens_hsa006000.17794147
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17270591
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.15997834
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.15369830
107Thyroid cancer_Homo sapiens_hsa052160.14535821
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13978045
109Legionellosis_Homo sapiens_hsa051340.13976707
110Galactose metabolism_Homo sapiens_hsa000520.13333646
111Measles_Homo sapiens_hsa051620.12457106
112Selenocompound metabolism_Homo sapiens_hsa004500.11653828
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11108863
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11082608
115Hepatitis B_Homo sapiens_hsa051610.10918186
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10446561
117Arginine and proline metabolism_Homo sapiens_hsa003300.10058230
118Phototransduction_Homo sapiens_hsa047440.09728574
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.09689606
120MicroRNAs in cancer_Homo sapiens_hsa052060.09464303
121TGF-beta signaling pathway_Homo sapiens_hsa043500.08761408
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.08706157
123Small cell lung cancer_Homo sapiens_hsa052220.08664490
124Apoptosis_Homo sapiens_hsa042100.08394798
125Type I diabetes mellitus_Homo sapiens_hsa049400.08002226
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05218306
127Carbon metabolism_Homo sapiens_hsa012000.04482844
128Biosynthesis of amino acids_Homo sapiens_hsa012300.04244017
129Shigellosis_Homo sapiens_hsa051310.01715988
130Pathways in cancer_Homo sapiens_hsa052000.01695774
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.00431228
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0079215

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