RPA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)9.79502599
2piRNA metabolic process (GO:0034587)9.45164697
3male meiosis I (GO:0007141)8.43867364
4DNA methylation involved in gamete generation (GO:0043046)7.79468617
5chromosome organization involved in meiosis (GO:0070192)7.45327801
6regulation of meiosis I (GO:0060631)7.44433140
7meiosis I (GO:0007127)6.54605443
8male meiosis (GO:0007140)6.43223872
9V(D)J recombination (GO:0033151)6.22960524
10synaptonemal complex assembly (GO:0007130)6.03449526
11negative regulation of thymocyte apoptotic process (GO:0070244)5.77166214
12synaptonemal complex organization (GO:0070193)5.44879359
13meiotic nuclear division (GO:0007126)5.41076688
14DNA synthesis involved in DNA repair (GO:0000731)5.18903476
15sister chromatid cohesion (GO:0007062)5.14101163
16resolution of meiotic recombination intermediates (GO:0000712)5.09105826
17meiotic cell cycle process (GO:1903046)4.87751846
18reciprocal DNA recombination (GO:0035825)4.54965785
19reciprocal meiotic recombination (GO:0007131)4.54965785
20negative regulation of interleukin-1 beta production (GO:0032691)4.54044038
21meiotic chromosome segregation (GO:0045132)4.45405073
22proteasome assembly (GO:0043248)4.12101636
23lactate metabolic process (GO:0006089)4.07066919
24positive regulation of meiosis (GO:0045836)4.00711479
25regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.99848077
26positive regulation of steroid hormone secretion (GO:2000833)3.93292532
27gene silencing by RNA (GO:0031047)3.89555833
28intra-S DNA damage checkpoint (GO:0031573)3.87856923
29activated T cell proliferation (GO:0050798)3.76424125
30negative regulation of interleukin-1 production (GO:0032692)3.71254071
31mesenchymal-epithelial cell signaling (GO:0060638)3.68545722
32histone H3-K36 demethylation (GO:0070544)3.66270732
33positive regulation of meiotic cell cycle (GO:0051446)3.66186167
34regulation of thymocyte apoptotic process (GO:0070243)3.65144639
35adult feeding behavior (GO:0008343)3.55469241
36somatic cell DNA recombination (GO:0016444)3.54644893
37somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.54644893
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.50837231
39female gamete generation (GO:0007292)3.50105284
40somatic diversification of immune receptors (GO:0002200)3.49003369
41response to hydroperoxide (GO:0033194)3.44011593
42regulation of interleukin-6 biosynthetic process (GO:0045408)3.40470287
43T cell lineage commitment (GO:0002360)3.38747346
44genitalia morphogenesis (GO:0035112)3.38443881
45growth hormone secretion (GO:0030252)3.36975005
46interkinetic nuclear migration (GO:0022027)3.32651031
47regulation of translation in response to stress (GO:0043555)3.31291748
48mitotic sister chromatid cohesion (GO:0007064)3.30342849
49positive regulation of growth hormone secretion (GO:0060124)3.27921745
50DNA alkylation (GO:0006305)3.26450084
51DNA methylation (GO:0006306)3.26450084
52decidualization (GO:0046697)3.26268957
53monoubiquitinated protein deubiquitination (GO:0035520)3.25851537
54cellular response to ethanol (GO:0071361)3.23222166
55regulation of transforming growth factor beta2 production (GO:0032909)3.18344640
56histone exchange (GO:0043486)3.16038286
57regulation of response to food (GO:0032095)3.15459433
58keratan sulfate catabolic process (GO:0042340)3.09585471
59regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.06539143
60attachment of spindle microtubules to kinetochore (GO:0008608)3.03386329
61purine nucleotide salvage (GO:0032261)2.98950018
62positive regulation of protein homodimerization activity (GO:0090073)2.97977991
63T cell differentiation in thymus (GO:0033077)2.97318917
64phosphate ion homeostasis (GO:0055062)2.94902243
65trivalent inorganic anion homeostasis (GO:0072506)2.94902243
66regulation of histone H3-K9 methylation (GO:0051570)2.94544075
67histone H3-K9 demethylation (GO:0033169)2.94478315
68rRNA methylation (GO:0031167)2.93349071
69negative regulation of gene silencing (GO:0060969)2.93221383
70regulation of nuclear cell cycle DNA replication (GO:0033262)2.90261465
71germ cell migration (GO:0008354)2.87849653
72regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85463339
73regulation of RIG-I signaling pathway (GO:0039535)2.84639325
74DNA modification (GO:0006304)2.83565200
75nucleotide transmembrane transport (GO:1901679)2.79818226
76serotonin metabolic process (GO:0042428)2.77691333
77negative regulation of DNA-dependent DNA replication (GO:2000104)2.72915955
78protein localization to cell surface (GO:0034394)2.72069101
79response to interferon-beta (GO:0035456)2.71277219
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.70499059
81oocyte development (GO:0048599)2.69602985
82primary amino compound metabolic process (GO:1901160)2.68776000
83chromatin remodeling at centromere (GO:0031055)2.66301377
84rRNA modification (GO:0000154)2.66040336
85indolalkylamine metabolic process (GO:0006586)2.63769861
86meiotic cell cycle (GO:0051321)2.63543176
87GMP metabolic process (GO:0046037)2.61119516
88nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.59787459
89replicative senescence (GO:0090399)2.59013364
90CENP-A containing nucleosome assembly (GO:0034080)2.57777178
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47576074
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47576074
93DNA replication-dependent nucleosome assembly (GO:0006335)2.46169552
94DNA replication-dependent nucleosome organization (GO:0034723)2.46169552
95DNA biosynthetic process (GO:0071897)2.45157162
96multicellular organismal movement (GO:0050879)2.43856551
97musculoskeletal movement (GO:0050881)2.43856551
98DNA methylation or demethylation (GO:0044728)2.43092556
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42194686
100endocrine hormone secretion (GO:0060986)2.40935935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.18714941
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.12599456
3VDR_22108803_ChIP-Seq_LS180_Human3.07609087
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.58317904
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.50179902
6IGF1R_20145208_ChIP-Seq_DFB_Human2.50005812
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.46696766
8ZNF274_21170338_ChIP-Seq_K562_Hela2.44604146
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39504925
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.31628691
11GATA1_22025678_ChIP-Seq_K562_Human2.19820881
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18691641
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17768304
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.06245761
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.03924230
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.97518751
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92259574
18PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89599562
19ELK1_19687146_ChIP-ChIP_HELA_Human1.84574298
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81519745
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79575467
22* EWS_26573619_Chip-Seq_HEK293_Human1.79027154
23PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.77525742
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76550099
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73745189
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68592996
27GBX2_23144817_ChIP-Seq_PC3_Human1.67313600
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.67124497
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66132675
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65583045
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64303822
32FUS_26573619_Chip-Seq_HEK293_Human1.62045943
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.61060519
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57395548
35TP53_22573176_ChIP-Seq_HFKS_Human1.46202939
36ER_23166858_ChIP-Seq_MCF-7_Human1.44061447
37* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42929934
38VDR_23849224_ChIP-Seq_CD4+_Human1.42438346
39* P300_19829295_ChIP-Seq_ESCs_Human1.42061507
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35411747
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34719631
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34012444
43VDR_24787735_ChIP-Seq_THP-1_Human1.33692031
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.32934322
45FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31532623
46RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29388649
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28444167
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28302608
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26994221
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26994221
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26994221
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26977378
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.26280977
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25629765
55SMRT_27268052_Chip-Seq_Bcells_Human1.25347585
56* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22793729
57TCF4_23295773_ChIP-Seq_U87_Human1.21474138
58FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21113410
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20432955
60TCF4_22108803_ChIP-Seq_LS180_Human1.20418278
61* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19503370
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19421512
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.19421512
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.19029818
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.14099775
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13993967
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13993967
68AR_25329375_ChIP-Seq_VCAP_Human1.11836621
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.11552094
70STAT3_23295773_ChIP-Seq_U87_Human1.10827496
71SOX2_19829295_ChIP-Seq_ESCs_Human1.10522962
72NANOG_19829295_ChIP-Seq_ESCs_Human1.10522962
73FOXP3_21729870_ChIP-Seq_TREG_Human1.10407472
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10314365
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09396700
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08622638
77CDX2_22108803_ChIP-Seq_LS180_Human1.08222324
78GATA3_26560356_Chip-Seq_TH2_Human1.07771737
79SMAD4_21799915_ChIP-Seq_A2780_Human1.07148333
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06452689
81SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06187790
82GATA3_26560356_Chip-Seq_TH1_Human1.05627431
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.04690067
84TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04510994
85* RUNX2_22187159_ChIP-Seq_PCA_Human1.03733951
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02824912
87BCAT_22108803_ChIP-Seq_LS180_Human1.01975388
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01685357
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00433546
90TAF15_26573619_Chip-Seq_HEK293_Human1.00370788
91HOXB7_26014856_ChIP-Seq_BT474_Human1.00265562
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00212337
93OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98845604
94STAT3_18555785_Chip-Seq_ESCs_Mouse0.98794169
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97483148
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96890630
97RUNX_20019798_ChIP-Seq_JUKART_Human0.96250965
98NOTCH1_21737748_ChIP-Seq_TLL_Human0.95823059
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95173511
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.94362852

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.98996092
2MP0002132_abnormal_respiratory_system4.62202110
3MP0002876_abnormal_thyroid_physiology4.21026550
4MP0005451_abnormal_body_composition3.53575603
5MP0009785_altered_susceptibility_to2.93465538
6MP0010094_abnormal_chromosome_stability2.91736201
7MP0008058_abnormal_DNA_repair2.84782120
8MP0009278_abnormal_bone_marrow2.57874575
9MP0002166_altered_tumor_susceptibility2.57034366
10MP0001835_abnormal_antigen_presentation2.43074191
11MP0002210_abnormal_sex_determination2.37646397
12MP0002006_tumorigenesis2.35449340
13MP0002160_abnormal_reproductive_system2.30662762
14MP0003693_abnormal_embryo_hatching2.19124305
15MP0005389_reproductive_system_phenotype2.06578643
16MP0001929_abnormal_gametogenesis1.98841540
17MP0006072_abnormal_retinal_apoptosis1.85190574
18MP0000427_abnormal_hair_cycle1.76856544
19MP0006054_spinal_hemorrhage1.74503172
20MP0005275_abnormal_skin_tensile1.70670978
21MP0001145_abnormal_male_reproductive1.69479454
22MP0000653_abnormal_sex_gland1.68760745
23MP0005084_abnormal_gallbladder_morpholo1.68522456
24MP0005671_abnormal_response_to1.66147847
25MP0005503_abnormal_tendon_morphology1.61176185
26MP0001879_abnormal_lymphatic_vessel1.60968367
27MP0000383_abnormal_hair_follicle1.57623182
28MP0005397_hematopoietic_system_phenotyp1.55464703
29MP0001545_abnormal_hematopoietic_system1.55464703
30MP0001243_abnormal_dermal_layer1.54103308
31MP0002095_abnormal_skin_pigmentation1.47923054
32MP0005387_immune_system_phenotype1.47045970
33MP0001790_abnormal_immune_system1.47045970
34MP0000015_abnormal_ear_pigmentation1.43831848
35MP0002102_abnormal_ear_morphology1.43018977
36MP0001800_abnormal_humoral_immune1.41173994
37MP0003698_abnormal_male_reproductive1.39580356
38MP0010386_abnormal_urinary_bladder1.37735727
39MP0001919_abnormal_reproductive_system1.37316122
40MP0003787_abnormal_imprinting1.33782340
41MP0000685_abnormal_immune_system1.32831283
42MP0002148_abnormal_hypersensitivity_rea1.31870357
43MP0008057_abnormal_DNA_replication1.30709826
44MP0003195_calcinosis1.26133201
45MP0008995_early_reproductive_senescence1.23169727
46MP0003786_premature_aging1.20445819
47MP0003950_abnormal_plasma_membrane1.18665386
48MP0001191_abnormal_skin_condition1.18428678
49MP0001542_abnormal_bone_strength1.17144029
50MP0003943_abnormal_hepatobiliary_system1.15310017
51MP0010155_abnormal_intestine_physiology1.14092478
52MP0001119_abnormal_female_reproductive1.13355792
53MP0000490_abnormal_crypts_of1.11858724
54MP0005645_abnormal_hypothalamus_physiol1.09946406
55MP0005410_abnormal_fertilization1.09807487
56MP0005253_abnormal_eye_physiology1.08531773
57MP0002723_abnormal_immune_serum1.08001068
58MP0010678_abnormal_skin_adnexa1.05879822
59MP0003763_abnormal_thymus_physiology1.04059049
60MP0002452_abnormal_antigen_presenting1.01443506
61MP0000470_abnormal_stomach_morphology0.98280608
62MP0004808_abnormal_hematopoietic_stem0.96878996
63MP0000462_abnormal_digestive_system0.95183890
64MP0008872_abnormal_physiological_respon0.93230223
65MP0006292_abnormal_olfactory_placode0.91728426
66MP0002420_abnormal_adaptive_immunity0.91305242
67MP0001905_abnormal_dopamine_level0.90303551
68MP0002419_abnormal_innate_immunity0.89877363
69MP0001819_abnormal_immune_cell0.85814361
70MP0003646_muscle_fatigue0.84936874
71MP0004947_skin_inflammation0.83540625
72MP0005000_abnormal_immune_tolerance0.81846280
73MP0005025_abnormal_response_to0.81804163
74MP0002396_abnormal_hematopoietic_system0.81639269
75MP0005360_urolithiasis0.80882184
76MP0002398_abnormal_bone_marrow0.79898646
77MP0005174_abnormal_tail_pigmentation0.79876979
78MP0000689_abnormal_spleen_morphology0.77340204
79MP0000716_abnormal_immune_system0.75849916
80MP0004142_abnormal_muscle_tone0.74267449
81MP0002928_abnormal_bile_duct0.74035456
82MP0001663_abnormal_digestive_system0.72433757
83MP0002998_abnormal_bone_remodeling0.72407111
84MP0003077_abnormal_cell_cycle0.71649940
85MP0000013_abnormal_adipose_tissue0.71131339
86MP0001849_ear_inflammation0.70744402
87MP0000703_abnormal_thymus_morphology0.70589432
88MP0005220_abnormal_exocrine_pancreas0.70268210
89MP0001845_abnormal_inflammatory_respons0.68118510
90MP0003699_abnormal_female_reproductive0.67350412
91MP0002161_abnormal_fertility/fecundity0.67143139
92MP0000371_diluted_coat_color0.66975973
93MP0000858_altered_metastatic_potential0.66751992
94MP0002075_abnormal_coat/hair_pigmentati0.65780910
95MP0001764_abnormal_homeostasis0.65012226
96MP0004036_abnormal_muscle_relaxation0.63884548
97MP0002722_abnormal_immune_system0.63640937
98MP0003567_abnormal_fetal_cardiomyocyte0.62201254
99MP0005551_abnormal_eye_electrophysiolog0.61208669
100MP0009764_decreased_sensitivity_to0.59895938

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)9.27995969
2Hypoproteinemia (HP:0003075)8.47589308
3Abnormality of B cell number (HP:0010975)8.40720738
4Panhypogammaglobulinemia (HP:0003139)7.72891467
5Thyroiditis (HP:0100646)7.59164716
6Hypoplasia of the thymus (HP:0000778)7.55862342
7Severe combined immunodeficiency (HP:0004430)7.04148707
8Combined immunodeficiency (HP:0005387)6.10329582
9Erythroderma (HP:0001019)4.79338913
10T lymphocytopenia (HP:0005403)4.73207363
11Eosinophilia (HP:0001880)4.50759671
12Absent frontal sinuses (HP:0002688)4.04286112
13Abnormality of T cell number (HP:0011839)3.92008611
14IgG deficiency (HP:0004315)3.80094574
15Volvulus (HP:0002580)3.77761333
16Granulocytopenia (HP:0001913)3.60725010
17Spondylolisthesis (HP:0003302)3.44957686
18Abnormality of eosinophils (HP:0001879)3.38216742
19Metaphyseal dysplasia (HP:0100255)3.14766524
20Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.10750053
21Recurrent fungal infections (HP:0002841)2.96928520
22Azoospermia (HP:0000027)2.91338150
23Recurrent viral infections (HP:0004429)2.86097429
24Abnormality of the frontal sinuses (HP:0002687)2.77059297
25Agammaglobulinemia (HP:0004432)2.69050157
26Meningitis (HP:0001287)2.47120814
27Abnormality of the pons (HP:0007361)2.37684168
28Hypoplasia of the pons (HP:0012110)2.32663081
29Leukocytosis (HP:0001974)2.31312307
30Chronic sinusitis (HP:0011109)2.31037323
31Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.25755112
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17813873
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.17813873
34Chromsome breakage (HP:0040012)2.15599156
35Aplasia/Hypoplasia of the thymus (HP:0010515)2.14188897
36Type I transferrin isoform profile (HP:0003642)2.13835963
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.03722666
38Subacute progressive viral hepatitis (HP:0006572)2.02706144
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02017384
40Abnormality of chromosome stability (HP:0003220)2.00806790
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.00155131
42Absent/shortened dynein arms (HP:0200106)2.00155131
43Abnormal spermatogenesis (HP:0008669)1.99396893
44Type II lissencephaly (HP:0007260)1.98285500
45Abnormality of T cells (HP:0002843)1.96796748
46Abnormality of midbrain morphology (HP:0002418)1.94641163
47Molar tooth sign on MRI (HP:0002419)1.94641163
48Stomach cancer (HP:0012126)1.93983610
49Methylmalonic acidemia (HP:0002912)1.91807664
50Abnormality of the renal collecting system (HP:0004742)1.86676989
51Abnormality of the renal medulla (HP:0100957)1.86321673
52Hypoplastic iliac wings (HP:0002866)1.85722372
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84499094
54Abnormal protein N-linked glycosylation (HP:0012347)1.84499094
55Abnormal protein glycosylation (HP:0012346)1.84499094
56Abnormal glycosylation (HP:0012345)1.84499094
57Scotoma (HP:0000575)1.82138425
58Metaphyseal cupping (HP:0003021)1.80451423
59Choroideremia (HP:0001139)1.80445588
60Nephronophthisis (HP:0000090)1.77737410
61Ectopic kidney (HP:0000086)1.73964968
62Sepsis (HP:0100806)1.73706052
63Abnormality of the ileum (HP:0001549)1.73261703
64Duplicated collecting system (HP:0000081)1.72246565
65Meckel diverticulum (HP:0002245)1.71701841
66Enlarged epiphyses (HP:0010580)1.71528717
6711 pairs of ribs (HP:0000878)1.71522997
68Aplasia/Hypoplasia of the tibia (HP:0005772)1.70427922
69Medial flaring of the eyebrow (HP:0010747)1.70201311
70Abnormality of DNA repair (HP:0003254)1.67817287
71Widely spaced teeth (HP:0000687)1.67763153
72Short tibia (HP:0005736)1.63994745
73Abnormality of the preputium (HP:0100587)1.63560416
74Abnormality of the vitamin B12 metabolism (HP:0004341)1.61873732
75Clubbing of toes (HP:0100760)1.60582303
76Hypoplasia of the radius (HP:0002984)1.60279992
77Gonadotropin excess (HP:0000837)1.58476571
78Oligodactyly (hands) (HP:0001180)1.57697403
79Osteomyelitis (HP:0002754)1.57656379
80Colon cancer (HP:0003003)1.56683822
81Abnormality of the renal cortex (HP:0011035)1.55232342
82Abnormality of the thymus (HP:0000777)1.49945916
83Fatigue (HP:0012378)1.49734411
84Abnormality of vitamin B metabolism (HP:0004340)1.49528729
85Delayed closure of the anterior fontanelle (HP:0001476)1.47668728
86Abnormal pancreas size (HP:0012094)1.45768112
87Homocystinuria (HP:0002156)1.45458595
88Abnormality of homocysteine metabolism (HP:0010919)1.45458595
89Chronic diarrhea (HP:0002028)1.45223407
90Micronodular cirrhosis (HP:0001413)1.44729585
91Abnormality of the phalanges of the 2nd finger (HP:0009541)1.43171691
92Nephrotic syndrome (HP:0000100)1.42498624
93Small intestinal stenosis (HP:0012848)1.41357780
94Duodenal stenosis (HP:0100867)1.41357780
95Prominent nose (HP:0000448)1.39255939
96Triphalangeal thumb (HP:0001199)1.39215298
97Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.39116008
98Short middle phalanx of the 5th finger (HP:0004220)1.38355758
99Recurrent bronchitis (HP:0002837)1.37943977
100Premature ovarian failure (HP:0008209)1.37740335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.24012578
2PNCK4.79137615
3MST44.11976732
4MET3.33032830
5BMPR1B3.26348143
6STK163.00701461
7CDK192.96781359
8INSRR2.74495777
9EIF2AK32.67295941
10FRK2.34773570
11TAOK32.28586034
12VRK12.21033189
13MAP3K122.09550087
14NLK2.02671995
15OXSR11.75908170
16TGFBR21.70897035
17MAP3K131.66778760
18CDK81.65304242
19NUAK11.58549762
20FLT31.58213471
21STK38L1.52950869
22PTK2B1.37762899
23ZAK1.32889023
24FES1.28546265
25PLK41.25892659
26PDK21.22030902
27TRPM71.22028010
28ADRBK21.21171521
29TEC1.19819290
30CSF1R1.19452608
31TGFBR11.13377447
32MAP3K91.11912230
33MAP3K141.08075556
34CAMK1G1.07254451
35STK101.02963039
36CLK11.02895577
37PLK30.99715779
38SRPK10.98667539
39PLK20.95064041
40KIT0.93216142
41PIK3CG0.88696026
42TYRO30.87863512
43CDK90.84401967
44MARK30.83512683
45PDGFRB0.83115135
46RIPK10.76098513
47TYK20.75870121
48PKN20.73647896
49BMX0.72666178
50FGR0.71975329
51GRK70.62506251
52CDK30.62385441
53MELK0.61984986
54ATM0.61682846
55IKBKB0.61190209
56MAP2K60.60626474
57CDK40.60055999
58RET0.59997017
59PLK10.59101789
60NEK90.56735207
61ATR0.55280017
62JAK30.55054054
63IRAK10.51215204
64GRK10.49628994
65PIK3CA0.49105789
66TTK0.48623372
67LYN0.47946953
68EGFR0.47747510
69CDK60.47462065
70VRK20.46532817
71MAP2K20.46122656
72PRKCE0.45936369
73SCYL20.45156528
74TXK0.43807031
75HIPK20.43458303
76ITK0.42982919
77ADRBK10.41087995
78CASK0.41082102
79MAPK130.40669755
80RPS6KB10.40528531
81IGF1R0.40114194
82MAP3K70.38445016
83MKNK20.37894656
84STK240.37740315
85PRKCI0.37297732
86CAMK10.36625688
87IRAK30.35668506
88WNK10.33941351
89TSSK60.28603932
90PIM10.28328587
91CHEK10.26661101
92LCK0.26479648
93BTK0.26270091
94ABL10.24450550
95RPS6KA50.23461640
96WNK30.22730889
97CSNK2A10.21469960
98TIE10.20610741
99DYRK1A0.20609353
100EIF2AK20.20363171

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034505.94184230
2Primary immunodeficiency_Homo sapiens_hsa053403.68712569
3Asthma_Homo sapiens_hsa053102.80076027
4Proteasome_Homo sapiens_hsa030502.67335700
5Propanoate metabolism_Homo sapiens_hsa006402.63516684
6Basal transcription factors_Homo sapiens_hsa030222.18183671
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.17455086
8* Homologous recombination_Homo sapiens_hsa034402.12683618
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04623079
10Graft-versus-host disease_Homo sapiens_hsa053322.01008876
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95861964
12Caffeine metabolism_Homo sapiens_hsa002321.89061179
13Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.85298062
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79992257
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.79498626
16Allograft rejection_Homo sapiens_hsa053301.78874540
17RNA transport_Homo sapiens_hsa030131.77095040
18Tryptophan metabolism_Homo sapiens_hsa003801.75893468
19Selenocompound metabolism_Homo sapiens_hsa004501.72489355
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.71307238
21Autoimmune thyroid disease_Homo sapiens_hsa053201.70961583
22Antigen processing and presentation_Homo sapiens_hsa046121.63801583
23RNA degradation_Homo sapiens_hsa030181.63173632
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59521845
25* Fanconi anemia pathway_Homo sapiens_hsa034601.56767939
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46631253
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.45443041
28Rheumatoid arthritis_Homo sapiens_hsa053231.42107736
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38962711
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37039932
31* Nucleotide excision repair_Homo sapiens_hsa034201.26055622
32Hematopoietic cell lineage_Homo sapiens_hsa046401.21900809
33Melanoma_Homo sapiens_hsa052181.11887429
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.11384247
35Cell cycle_Homo sapiens_hsa041101.08163133
36Type I diabetes mellitus_Homo sapiens_hsa049401.04794322
37Protein export_Homo sapiens_hsa030600.95514537
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95437191
39Leishmaniasis_Homo sapiens_hsa051400.93352240
40Viral myocarditis_Homo sapiens_hsa054160.91239412
41Fatty acid elongation_Homo sapiens_hsa000620.89986856
42Phototransduction_Homo sapiens_hsa047440.89542028
43Linoleic acid metabolism_Homo sapiens_hsa005910.89206260
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83111714
45p53 signaling pathway_Homo sapiens_hsa041150.82708022
46Oxidative phosphorylation_Homo sapiens_hsa001900.82280880
47Parkinsons disease_Homo sapiens_hsa050120.80925024
48N-Glycan biosynthesis_Homo sapiens_hsa005100.80750218
49Measles_Homo sapiens_hsa051620.80134142
50Staphylococcus aureus infection_Homo sapiens_hsa051500.77811396
51Shigellosis_Homo sapiens_hsa051310.77432709
52Dorso-ventral axis formation_Homo sapiens_hsa043200.76429985
53Regulation of autophagy_Homo sapiens_hsa041400.74893779
54Legionellosis_Homo sapiens_hsa051340.74863537
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74805825
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.71715294
57Oocyte meiosis_Homo sapiens_hsa041140.71202747
58Influenza A_Homo sapiens_hsa051640.67668800
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63851645
60Malaria_Homo sapiens_hsa051440.59399980
61Toxoplasmosis_Homo sapiens_hsa051450.57490850
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56846990
63FoxO signaling pathway_Homo sapiens_hsa040680.56803621
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56179793
65mRNA surveillance pathway_Homo sapiens_hsa030150.55078068
66Fatty acid metabolism_Homo sapiens_hsa012120.55066200
67Collecting duct acid secretion_Homo sapiens_hsa049660.54965344
68B cell receptor signaling pathway_Homo sapiens_hsa046620.53476497
69Olfactory transduction_Homo sapiens_hsa047400.52947275
70TNF signaling pathway_Homo sapiens_hsa046680.50057879
71Butanoate metabolism_Homo sapiens_hsa006500.49973584
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49635197
73Herpes simplex infection_Homo sapiens_hsa051680.47412855
74* DNA replication_Homo sapiens_hsa030300.45440445
75Renin-angiotensin system_Homo sapiens_hsa046140.45122967
76Huntingtons disease_Homo sapiens_hsa050160.45026725
77* Mismatch repair_Homo sapiens_hsa034300.43878617
78Arachidonic acid metabolism_Homo sapiens_hsa005900.43066417
79HTLV-I infection_Homo sapiens_hsa051660.41639262
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.41441020
81Base excision repair_Homo sapiens_hsa034100.41106965
82Pertussis_Homo sapiens_hsa051330.40556529
83Epstein-Barr virus infection_Homo sapiens_hsa051690.39657491
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.39464401
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39318240
86beta-Alanine metabolism_Homo sapiens_hsa004100.38241185
87Arginine and proline metabolism_Homo sapiens_hsa003300.37991702
88RNA polymerase_Homo sapiens_hsa030200.37745883
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.37553956
90Osteoclast differentiation_Homo sapiens_hsa043800.36560627
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35344487
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34949243
93One carbon pool by folate_Homo sapiens_hsa006700.34539476
94Pyruvate metabolism_Homo sapiens_hsa006200.34512701
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33613504
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33144214
97TGF-beta signaling pathway_Homo sapiens_hsa043500.31205261
98Glycerolipid metabolism_Homo sapiens_hsa005610.30905255
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.29795040
100Ether lipid metabolism_Homo sapiens_hsa005650.29546178

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