RPAIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.63893827
2behavioral response to nicotine (GO:0035095)4.67229732
3ATP synthesis coupled proton transport (GO:0015986)4.63387869
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.63387869
5DNA deamination (GO:0045006)4.46222529
6telomere maintenance via semi-conservative replication (GO:0032201)4.31882698
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.10972425
8regulation of RIG-I signaling pathway (GO:0039535)4.06493553
9proteasome assembly (GO:0043248)3.94266824
10DNA strand elongation involved in DNA replication (GO:0006271)3.87953304
11telomere maintenance via recombination (GO:0000722)3.87749277
12regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.82703217
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82515351
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.82515351
15NADH dehydrogenase complex assembly (GO:0010257)3.82515351
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.74397530
17DNA strand elongation (GO:0022616)3.71533517
18respiratory electron transport chain (GO:0022904)3.67041352
19electron transport chain (GO:0022900)3.65728672
20protein complex biogenesis (GO:0070271)3.63201275
21pyrimidine nucleobase catabolic process (GO:0006208)3.53293134
22ribosomal small subunit biogenesis (GO:0042274)3.40208330
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.39965011
24nucleotide-excision repair, DNA gap filling (GO:0006297)3.38787197
25mitochondrial respiratory chain complex assembly (GO:0033108)3.36495304
26viral transcription (GO:0019083)3.35874122
27respiratory chain complex IV assembly (GO:0008535)3.35021414
28mitotic recombination (GO:0006312)3.34277604
29termination of RNA polymerase III transcription (GO:0006386)3.34029985
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.34029985
31L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.32808815
32nonmotile primary cilium assembly (GO:0035058)3.31869466
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28341024
34antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.27059395
35water-soluble vitamin biosynthetic process (GO:0042364)3.26344098
36translational termination (GO:0006415)3.23675522
37protein neddylation (GO:0045116)3.21103905
38regulation of cellular amino acid metabolic process (GO:0006521)3.19648485
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.13790622
40DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.12344382
41protein-cofactor linkage (GO:0018065)3.10639999
427-methylguanosine RNA capping (GO:0009452)3.10197053
43RNA capping (GO:0036260)3.10197053
44maturation of SSU-rRNA (GO:0030490)3.09472008
45cytochrome complex assembly (GO:0017004)3.09030112
46cotranslational protein targeting to membrane (GO:0006613)3.08518642
47DNA replication initiation (GO:0006270)3.08394489
487-methylguanosine mRNA capping (GO:0006370)3.07622933
49intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07242294
50signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07242294
51telomere maintenance via telomere lengthening (GO:0010833)3.07033125
52signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05488930
53signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05488930
54signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05488930
55epithelial cilium movement (GO:0003351)3.05357775
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04258550
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04258550
58cellular protein complex disassembly (GO:0043624)3.02693841
59protein targeting to ER (GO:0045047)3.02559782
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99257454
61deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.98739973
62neutrophil activation involved in immune response (GO:0002283)2.97737075
63transcription-coupled nucleotide-excision repair (GO:0006283)2.97270471
642-deoxyribonucleotide biosynthetic process (GO:0009265)2.96644518
65deoxyribose phosphate biosynthetic process (GO:0046385)2.96644518
66pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96395583
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96207998
68translational elongation (GO:0006414)2.95413517
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95245434
70negative regulation of ligase activity (GO:0051352)2.95245434
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92853752
72response to interferon-beta (GO:0035456)2.92773848
73polyketide metabolic process (GO:0030638)2.91692248
74doxorubicin metabolic process (GO:0044598)2.91692248
75daunorubicin metabolic process (GO:0044597)2.91692248
76protein localization to endoplasmic reticulum (GO:0070972)2.90926777
77metallo-sulfur cluster assembly (GO:0031163)2.90873170
78iron-sulfur cluster assembly (GO:0016226)2.90873170
79pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.90863670
80signal transduction involved in DNA damage checkpoint (GO:0072422)2.89804857
81signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89804857
82regulation of cilium movement (GO:0003352)2.88232445
83nucleobase catabolic process (GO:0046113)2.87884881
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87685429
85signal transduction involved in cell cycle checkpoint (GO:0072395)2.86947843
86L-methionine biosynthetic process (GO:0071265)2.86762735
87amino acid salvage (GO:0043102)2.86762735
88L-methionine salvage (GO:0071267)2.86762735
89DNA damage response, detection of DNA damage (GO:0042769)2.86669990
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86181564
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83248479
92intraciliary transport (GO:0042073)2.82693764
93establishment of protein localization to endoplasmic reticulum (GO:0072599)2.82554913
94translational initiation (GO:0006413)2.82290198
95chaperone-mediated protein transport (GO:0072321)2.81720119
96fucose catabolic process (GO:0019317)2.81664553
97L-fucose metabolic process (GO:0042354)2.81664553
98L-fucose catabolic process (GO:0042355)2.81664553
99cellular response to interferon-beta (GO:0035458)2.81460919
100sequestering of actin monomers (GO:0042989)2.80259149
101negative regulation of telomere maintenance (GO:0032205)2.79075712
102exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.78415671
103somite development (GO:0061053)2.77481100
104translation (GO:0006412)2.77456696
105purine nucleobase biosynthetic process (GO:0009113)2.77344312
106regulation of nuclear cell cycle DNA replication (GO:0033262)2.74329938
107CENP-A containing nucleosome assembly (GO:0034080)2.73547232
108intracellular protein transmembrane import (GO:0044743)2.72347891
109DNA replication checkpoint (GO:0000076)2.70633846
110mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69934682
111heme biosynthetic process (GO:0006783)2.69257922
112cellular component biogenesis (GO:0044085)2.68436816
113deoxyribonucleotide biosynthetic process (GO:0009263)2.68347452
114hydrogen ion transmembrane transport (GO:1902600)2.66902352
115purine-containing compound salvage (GO:0043101)2.66813901
116pseudouridine synthesis (GO:0001522)2.66290942
117viral life cycle (GO:0019058)2.65902329
118protein localization to cilium (GO:0061512)2.65534423
119deoxyribonucleotide catabolic process (GO:0009264)2.64449547
120platelet dense granule organization (GO:0060155)2.64258330
121DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.63697826
122protein complex disassembly (GO:0043241)2.63553410
123defense response to protozoan (GO:0042832)2.63097562
124ribosomal large subunit biogenesis (GO:0042273)2.62509110
125detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62105633
126nucleobase biosynthetic process (GO:0046112)2.61774166
127heme metabolic process (GO:0042168)2.61592899
128replication fork processing (GO:0031297)2.61174236
129ribonucleoprotein complex biogenesis (GO:0022613)2.61036367
130chromatin remodeling at centromere (GO:0031055)2.60243801
131limb bud formation (GO:0060174)2.59956574
132ubiquinone metabolic process (GO:0006743)2.59915318
133retinal ganglion cell axon guidance (GO:0031290)2.59775276
134neural tube formation (GO:0001841)2.59281128
135ATP biosynthetic process (GO:0006754)2.59223203
136antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.58922224
137spliceosomal snRNP assembly (GO:0000387)2.58558433
138spliceosomal complex assembly (GO:0000245)2.58388401
139ubiquinone biosynthetic process (GO:0006744)2.58346045
140rRNA modification (GO:0000154)2.56875783
141protein polyglutamylation (GO:0018095)2.56850703
142presynaptic membrane organization (GO:0097090)2.56725513
143mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.56699239
144macromolecular complex disassembly (GO:0032984)2.56694326
145regulation of mitochondrial translation (GO:0070129)2.56357453
146presynaptic membrane assembly (GO:0097105)2.55590969
147purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.54392716
148purine nucleoside triphosphate biosynthetic process (GO:0009145)2.53091037
149axoneme assembly (GO:0035082)2.52450114
150kidney morphogenesis (GO:0060993)2.52333283
151cilium morphogenesis (GO:0060271)2.51611365
152negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51504822
153preassembly of GPI anchor in ER membrane (GO:0016254)2.50551223
154proton transport (GO:0015992)2.50110324
155neuron fate determination (GO:0048664)2.49841020
156mannosylation (GO:0097502)2.45942461
157hydrogen transport (GO:0006818)2.45165621
158transmission of nerve impulse (GO:0019226)2.44213040
159cilium movement (GO:0003341)2.44101822
160DNA double-strand break processing (GO:0000729)2.41298640
161negative regulation of translation, ncRNA-mediated (GO:0040033)2.40428324
162regulation of translation, ncRNA-mediated (GO:0045974)2.40428324
163negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.40428324
164nuclear-transcribed mRNA catabolic process (GO:0000956)2.39419241
165GTP biosynthetic process (GO:0006183)2.39096174
166tRNA processing (GO:0008033)2.38474888
167cilium organization (GO:0044782)2.37609358
168spinal cord motor neuron differentiation (GO:0021522)2.37457393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.60999923
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.14398869
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.63522808
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.62371097
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.46624899
6EZH2_22144423_ChIP-Seq_EOC_Human3.45703724
7ZNF274_21170338_ChIP-Seq_K562_Hela3.29923475
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27734344
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.22995874
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.18222188
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.10197805
12IRF8_22096565_ChIP-ChIP_GC-B_Human3.06915056
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.96125730
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.79024151
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73773872
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71593033
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64354047
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.59917535
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.58488111
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.55012784
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54786696
22VDR_23849224_ChIP-Seq_CD4+_Human2.53609006
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51946252
24VDR_22108803_ChIP-Seq_LS180_Human2.51025844
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49495529
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46379173
27IGF1R_20145208_ChIP-Seq_DFB_Human2.41120374
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36763754
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30641223
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.29775239
31FUS_26573619_Chip-Seq_HEK293_Human2.29062698
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27720627
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26269147
34EWS_26573619_Chip-Seq_HEK293_Human2.20837796
35FOXP3_21729870_ChIP-Seq_TREG_Human2.18141200
36MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16066437
37DCP1A_22483619_ChIP-Seq_HELA_Human2.15646020
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15214976
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.09250033
40GBX2_23144817_ChIP-Seq_PC3_Human2.09229573
41HOXB4_20404135_ChIP-ChIP_EML_Mouse2.08173591
42ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08150514
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06545014
44BP1_19119308_ChIP-ChIP_Hs578T_Human2.06026359
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98950914
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97716078
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94238669
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93337137
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.88545719
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.88255359
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86912189
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86615527
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.85227598
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85136478
55ELK1_19687146_ChIP-ChIP_HELA_Human1.85132264
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82538659
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81949798
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77511176
59TAF15_26573619_Chip-Seq_HEK293_Human1.77214305
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74235099
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71211525
62P300_19829295_ChIP-Seq_ESCs_Human1.70992506
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.70478491
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.70466746
65XRN2_22483619_ChIP-Seq_HELA_Human1.70293980
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68815133
67GABP_19822575_ChIP-Seq_HepG2_Human1.68499014
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65887822
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65788404
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.63620733
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62026582
72* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61140501
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60930368
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59379504
75SPI1_23547873_ChIP-Seq_NB4_Human1.59052067
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54681034
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53084586
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53023852
79GATA1_22025678_ChIP-Seq_K562_Human1.52189481
80RNF2_27304074_Chip-Seq_NSC_Mouse1.51939375
81TTF2_22483619_ChIP-Seq_HELA_Human1.47341879
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46383522
83IRF1_19129219_ChIP-ChIP_H3396_Human1.43582736
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.42307645
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42183467
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42092105
87TP53_22573176_ChIP-Seq_HFKS_Human1.41593953
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40691721
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40387807
90REST_21632747_ChIP-Seq_MESCs_Mouse1.38464793
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37068919
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.36393111
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34658912
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.30522823
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29913680
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29913680
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27737558
98SOX2_16153702_ChIP-ChIP_HESCs_Human1.27137679
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26997279
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23340074
101ER_23166858_ChIP-Seq_MCF-7_Human1.23069463
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21140466
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20219621
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17736338
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16797064
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16031135
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15573323
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15169695
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13351434
110SCL_19346495_ChIP-Seq_HPC-7_Human1.13257453
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12626646
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12188525
113CBP_20019798_ChIP-Seq_JUKART_Human1.12188525
114MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10673165
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10181253
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08495433
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07666448
118YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07606833
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07235182
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06498709
121LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06346995
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06323078
123CIITA_25753668_ChIP-Seq_RAJI_Human1.05648218
124MYC_18940864_ChIP-ChIP_HL60_Human1.04870046
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04171969
126MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02944838
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02914851
128REST_18959480_ChIP-ChIP_MESCs_Mouse1.02397383
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.01366563
130NANOG_19829295_ChIP-Seq_ESCs_Human1.01359740
131SOX2_19829295_ChIP-Seq_ESCs_Human1.01359740
132PIAS1_25552417_ChIP-Seq_VCAP_Human1.01230733
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01146471
134AR_25329375_ChIP-Seq_VCAP_Human1.00287784
135PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99600568
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98930715
137JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98322882
138FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98285969
139FOXA1_25329375_ChIP-Seq_VCAP_Human0.98285969
140NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96905124
141EED_16625203_ChIP-ChIP_MESCs_Mouse0.96522639
142BCAT_22108803_ChIP-Seq_LS180_Human0.96273338
143* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95226480
144SMAD4_21799915_ChIP-Seq_A2780_Human0.94178326
145ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93932110
146* NCOR_22424771_ChIP-Seq_293T_Human0.93796485
147ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93057340
148PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92819815
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92392886
150* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91559126
151ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91366617
152GATA3_21878914_ChIP-Seq_MCF-7_Human0.90587508
153RUNX2_22187159_ChIP-Seq_PCA_Human0.90087624
154TCF4_22108803_ChIP-Seq_LS180_Human0.89743836
155ELK1_22589737_ChIP-Seq_MCF10A_Human0.88929402
156CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87612097
157GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87573333
158PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86905248
159FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86335974
160MYB_26560356_Chip-Seq_TH1_Human0.85827476
161IRF8_27001747_Chip-Seq_BMDM_Mouse0.85677794
162* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85077300
163SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81194777
164NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80875790
165KDM5A_27292631_Chip-Seq_BREAST_Human0.80486212
166AR_21909140_ChIP-Seq_LNCAP_Human0.79477876
167RUNX1_22412390_ChIP-Seq_EML_Mouse0.79341302
168TFEB_21752829_ChIP-Seq_HELA_Human0.78200135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.91900648
2MP0009785_altered_susceptibility_to3.20439643
3MP0008057_abnormal_DNA_replication2.98199634
4MP0002148_abnormal_hypersensitivity_rea2.77815289
5MP0003693_abnormal_embryo_hatching2.62321872
6MP0003880_abnormal_central_pattern2.61391930
7MP0003136_yellow_coat_color2.56271801
8MP0003186_abnormal_redox_activity2.56125884
9MP0008058_abnormal_DNA_repair2.54753730
10MP0003656_abnormal_erythrocyte_physiolo2.52185385
11MP0002396_abnormal_hematopoietic_system2.50988136
12MP0005671_abnormal_response_to2.49133970
13MP0010094_abnormal_chromosome_stability2.46805711
14MP0002653_abnormal_ependyma_morphology2.39988990
15MP0003806_abnormal_nucleotide_metabolis2.31639223
16MP0009379_abnormal_foot_pigmentation2.28783153
17MP0003787_abnormal_imprinting2.21911369
18MP0003724_increased_susceptibility_to2.20974513
19MP0003763_abnormal_thymus_physiology2.16031493
20MP0005025_abnormal_response_to2.10018147
21MP0004147_increased_porphyrin_level2.09719218
22MP0002938_white_spotting2.05913786
23MP0006072_abnormal_retinal_apoptosis2.05355174
24MP0000685_abnormal_immune_system1.99737187
25MP0003077_abnormal_cell_cycle1.99424330
26MP0001853_heart_inflammation1.98639803
27MP0004142_abnormal_muscle_tone1.96609929
28MP0009697_abnormal_copulation1.93573451
29MP0009333_abnormal_splenocyte_physiolog1.92269202
30MP0001800_abnormal_humoral_immune1.90661795
31MP0002723_abnormal_immune_serum1.90469584
32MP0002638_abnormal_pupillary_reflex1.87871037
33MP0005000_abnormal_immune_tolerance1.86736535
34MP0002419_abnormal_innate_immunity1.85361330
35MP0008789_abnormal_olfactory_epithelium1.84364627
36MP0000778_abnormal_nervous_system1.83056663
37MP0002452_abnormal_antigen_presenting1.82385399
38MP0008007_abnormal_cellular_replicative1.80321169
39MP0002398_abnormal_bone_marrow1.79574273
40MP0005387_immune_system_phenotype1.78656937
41MP0001790_abnormal_immune_system1.78656937
42MP0001968_abnormal_touch/_nociception1.78599526
43MP0006276_abnormal_autonomic_nervous1.77585447
44MP0002163_abnormal_gland_morphology1.77404415
45MP0002420_abnormal_adaptive_immunity1.77339514
46MP0005551_abnormal_eye_electrophysiolog1.77136550
47MP0001545_abnormal_hematopoietic_system1.76363379
48MP0005397_hematopoietic_system_phenotyp1.76363379
49MP0002132_abnormal_respiratory_system1.76258157
50MP0000631_abnormal_neuroendocrine_gland1.75994203
51MP0001819_abnormal_immune_cell1.75885012
52MP0004957_abnormal_blastocyst_morpholog1.74782192
53MP0003121_genomic_imprinting1.69821666
54MP0006036_abnormal_mitochondrial_physio1.65770723
55MP0009046_muscle_twitch1.65646425
56MP0003111_abnormal_nucleus_morphology1.65376173
57MP0005423_abnormal_somatic_nervous1.64088468
58MP0004133_heterotaxia1.63701241
59MP0001984_abnormal_olfaction1.61842260
60MP0005645_abnormal_hypothalamus_physiol1.61656309
61MP0002736_abnormal_nociception_after1.61045718
62MP0003122_maternal_imprinting1.61023345
63MP0000716_abnormal_immune_system1.60382343
64MP0002837_dystrophic_cardiac_calcinosis1.59345577
65MP0004885_abnormal_endolymph1.58421599
66MP0005394_taste/olfaction_phenotype1.58088274
67MP0005499_abnormal_olfactory_system1.58088274
68MP0003786_premature_aging1.57430925
69MP0000689_abnormal_spleen_morphology1.57299886
70MP0002876_abnormal_thyroid_physiology1.55897800
71MP0005075_abnormal_melanosome_morpholog1.54959986
72MP0009745_abnormal_behavioral_response1.53625960
73MP0002429_abnormal_blood_cell1.52327802
74MP0009764_decreased_sensitivity_to1.51504878
75MP0003436_decreased_susceptibility_to1.50900669
76MP0005253_abnormal_eye_physiology1.48814611
77MP0002272_abnormal_nervous_system1.48294469
78MP0002722_abnormal_immune_system1.48049374
79MP0001293_anophthalmia1.47318990
80MP0006082_CNS_inflammation1.44166760
81MP0001485_abnormal_pinna_reflex1.43808176
82MP0001188_hyperpigmentation1.41190884
83MP0000569_abnormal_digit_pigmentation1.40923995
84MP0000015_abnormal_ear_pigmentation1.40552912
85MP0001764_abnormal_homeostasis1.38195007
86MP0005174_abnormal_tail_pigmentation1.37926260
87MP0000490_abnormal_crypts_of1.37430637
88MP0008995_early_reproductive_senescence1.37170929
89MP0008469_abnormal_protein_level1.36131754
90MP0002138_abnormal_hepatobiliary_system1.33236570
91MP0004742_abnormal_vestibular_system1.33158964
92MP0005379_endocrine/exocrine_gland_phen1.32716940
93MP0003890_abnormal_embryonic-extraembry1.32582563
94MP0002751_abnormal_autonomic_nervous1.31558144
95MP0002557_abnormal_social/conspecific_i1.31252783
96MP0002735_abnormal_chemical_nociception1.31002733
97MP0002405_respiratory_system_inflammati1.30178855
98MP0002166_altered_tumor_susceptibility1.29196344
99MP0003011_delayed_dark_adaptation1.28832287
100MP0005646_abnormal_pituitary_gland1.27966550
101MP0002572_abnormal_emotion/affect_behav1.25593292
102MP0002184_abnormal_innervation1.25353307
103MP0001486_abnormal_startle_reflex1.21942068
104MP0002822_catalepsy1.21449078
105MP0002234_abnormal_pharynx_morphology1.20229723
106MP0000049_abnormal_middle_ear1.19693895
107MP0003938_abnormal_ear_development1.19506172
108MP0005084_abnormal_gallbladder_morpholo1.18040063
109MP0002006_tumorigenesis1.17494703
110MP0004145_abnormal_muscle_electrophysio1.17258526
111MP0002752_abnormal_somatic_nervous1.16693110
112MP0003635_abnormal_synaptic_transmissio1.16339804
113MP0005464_abnormal_platelet_physiology1.16289298
114MP0001529_abnormal_vocalization1.12550065
115MP0008877_abnormal_DNA_methylation1.12490377
116MP0001845_abnormal_inflammatory_respons1.12162823
117MP0002064_seizures1.11944805
118MP0002095_abnormal_skin_pigmentation1.11861514
119MP0006292_abnormal_olfactory_placode1.10729488
120MP0005058_abnormal_lysosome_morphology1.10456269
121MP0003937_abnormal_limbs/digits/tail_de1.09600358
122MP0000026_abnormal_inner_ear1.08881701
123MP0002067_abnormal_sensory_capabilities1.08285615
124MP0008932_abnormal_embryonic_tissue1.07784916
125MP0005195_abnormal_posterior_eye1.07596204
126MP0002734_abnormal_mechanical_nocicepti1.07595800
127MP0003119_abnormal_digestive_system1.06921765
128MP0006035_abnormal_mitochondrial_morpho1.06390145
129MP0003567_abnormal_fetal_cardiomyocyte1.06311868
130MP0000703_abnormal_thymus_morphology1.06176837
131MP0002063_abnormal_learning/memory/cond1.05996263
132MP0001986_abnormal_taste_sensitivity1.05747836
133MP0000955_abnormal_spinal_cord1.05643432
134MP0000566_synostosis1.02877799
135MP0002277_abnormal_respiratory_mucosa1.02100380
136MP0001970_abnormal_pain_threshold0.99568069
137MP0002733_abnormal_thermal_nociception0.98275783
138MP0001286_abnormal_eye_development0.98242980
139MP0010030_abnormal_orbit_morphology0.97260908
140MP0001542_abnormal_bone_strength0.97046604
141MP0002102_abnormal_ear_morphology0.96964844
142MP0003718_maternal_effect0.96696309
143MP0006054_spinal_hemorrhage0.96444630
144MP0002019_abnormal_tumor_incidence0.96110639
145MP0002233_abnormal_nose_morphology0.95596087
146MP0002928_abnormal_bile_duct0.93633338
147MP0002882_abnormal_neuron_morphology0.93613075
148MP0005391_vision/eye_phenotype0.93455823
149MP0009763_increased_sensitivity_to0.93220183
150MP0002160_abnormal_reproductive_system0.93093877
151MP0000372_irregular_coat_pigmentation0.91859995
152MP0005310_abnormal_salivary_gland0.91626671
153MP0003172_abnormal_lysosome_physiology0.90365240
154MP0004924_abnormal_behavior0.89763231
155MP0005386_behavior/neurological_phenoty0.89763231
156MP0004808_abnormal_hematopoietic_stem0.89034903
157MP0005636_abnormal_mineral_homeostasis0.88887750
158MP0000313_abnormal_cell_death0.87620936
159MP0002210_abnormal_sex_determination0.87106179
160MP0005408_hypopigmentation0.84519186
161MP0003195_calcinosis0.84448631
162MP0003861_abnormal_nervous_system0.82561862
163MP0000647_abnormal_sebaceous_gland0.82100303
164MP0004043_abnormal_pH_regulation0.81683757
165MP0003315_abnormal_perineum_morphology0.81504277
166MP0010155_abnormal_intestine_physiology0.80835809
167MP0001324_abnormal_eye_pigmentation0.80632156
168MP0001348_abnormal_lacrimal_gland0.77673727
169MP0001905_abnormal_dopamine_level0.77576415
170MP0004782_abnormal_surfactant_physiolog0.76941028
171MP0000858_altered_metastatic_potential0.76861949
172MP0005085_abnormal_gallbladder_physiolo0.75758853
173MP0009765_abnormal_xenobiotic_induced0.72063517
174MP0004510_myositis0.71652698
175MP0009840_abnormal_foam_cell0.71501866
176MP0001873_stomach_inflammation0.70361035
177MP0002139_abnormal_hepatobiliary_system0.69018513
178MP0005584_abnormal_enzyme/coenzyme_acti0.68769647
179MP0001119_abnormal_female_reproductive0.67608515
180MP0005409_darkened_coat_color0.66993822
181MP0008872_abnormal_physiological_respon0.65397180

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.31757573
2Abnormality of cells of the erythroid lineage (HP:0012130)4.22755537
3Aplastic anemia (HP:0001915)4.16127306
4Abnormality of the heme biosynthetic pathway (HP:0010472)4.02497809
5Acute necrotizing encephalopathy (HP:0006965)3.89147239
63-Methylglutaconic aciduria (HP:0003535)3.77978757
7Pancreatic cysts (HP:0001737)3.73534823
8Mitochondrial inheritance (HP:0001427)3.70944084
9Type I transferrin isoform profile (HP:0003642)3.64831993
10Molar tooth sign on MRI (HP:0002419)3.63292362
11Abnormality of midbrain morphology (HP:0002418)3.63292362
12Hepatocellular necrosis (HP:0001404)3.60566226
13Abnormal mitochondria in muscle tissue (HP:0008316)3.58499607
14Reticulocytopenia (HP:0001896)3.52047289
15Pancreatic fibrosis (HP:0100732)3.49290171
16True hermaphroditism (HP:0010459)3.39302017
17Increased CSF lactate (HP:0002490)3.37061214
18Hepatic necrosis (HP:0002605)3.33804428
19Acute encephalopathy (HP:0006846)3.27640738
20Nephronophthisis (HP:0000090)3.26921062
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.09501668
22Microvesicular hepatic steatosis (HP:0001414)3.09200901
23Medial flaring of the eyebrow (HP:0010747)3.08884724
24Progressive macrocephaly (HP:0004481)3.02243114
25Congenital stationary night blindness (HP:0007642)2.93710055
26Exertional dyspnea (HP:0002875)2.93378704
27Petechiae (HP:0000967)2.92232880
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.90428305
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.90428305
30Increased serum lactate (HP:0002151)2.88656123
31Reduced antithrombin III activity (HP:0001976)2.84515883
32Chromsome breakage (HP:0040012)2.81307544
33Increased hepatocellular lipid droplets (HP:0006565)2.80436684
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.78879512
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78616273
36Recurrent abscess formation (HP:0002722)2.78246672
37Abnormality of the renal medulla (HP:0100957)2.75326056
38Colon cancer (HP:0003003)2.70188771
39Renal Fanconi syndrome (HP:0001994)2.70099222
40Abnormality of the labia minora (HP:0012880)2.64061060
41Thrombocytosis (HP:0001894)2.63932703
42Gait imbalance (HP:0002141)2.62710763
43Recurrent bacterial skin infections (HP:0005406)2.61610174
44Elevated erythrocyte sedimentation rate (HP:0003565)2.61463464
45Hypothermia (HP:0002045)2.59908266
46Lipid accumulation in hepatocytes (HP:0006561)2.57800348
47Abnormal protein glycosylation (HP:0012346)2.51639831
48Abnormal glycosylation (HP:0012345)2.51639831
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51639831
50Abnormal protein N-linked glycosylation (HP:0012347)2.51639831
51Congenital primary aphakia (HP:0007707)2.49946904
52Pancytopenia (HP:0001876)2.47759584
53Birth length less than 3rd percentile (HP:0003561)2.46210089
54Exercise intolerance (HP:0003546)2.45139274
55Macrocytic anemia (HP:0001972)2.43723839
56Optic disc pallor (HP:0000543)2.40981274
57Abnormality of the renal cortex (HP:0011035)2.40275878
58Cerebral edema (HP:0002181)2.39288029
59Nephrogenic diabetes insipidus (HP:0009806)2.37011861
60Pallor (HP:0000980)2.34243906
61Lactic acidosis (HP:0003128)2.32828378
62IgM deficiency (HP:0002850)2.32146479
63Increased IgM level (HP:0003496)2.31288378
64Pendular nystagmus (HP:0012043)2.26821552
65Increased intramyocellular lipid droplets (HP:0012240)2.25649645
66Type II lissencephaly (HP:0007260)2.25588210
67Sclerocornea (HP:0000647)2.25478286
68Neutropenia (HP:0001875)2.25031686
69Oral leukoplakia (HP:0002745)2.23540697
70Hyperglycinemia (HP:0002154)2.22948669
71Septo-optic dysplasia (HP:0100842)2.22672344
72Rib fusion (HP:0000902)2.21987383
73Autoimmune thrombocytopenia (HP:0001973)2.21048538
74Methylmalonic acidemia (HP:0002912)2.16295210
75Cystic liver disease (HP:0006706)2.16123163
76Abnormality of glycolysis (HP:0004366)2.15682468
77Increased serum pyruvate (HP:0003542)2.15682468
78Genital tract atresia (HP:0001827)2.14886181
79Vaginal atresia (HP:0000148)2.14239171
80Anencephaly (HP:0002323)2.13243012
81Congenital, generalized hypertrichosis (HP:0004540)2.12477020
82Respiratory difficulties (HP:0002880)2.11864476
83Chronic hepatic failure (HP:0100626)2.10716105
84Prolonged partial thromboplastin time (HP:0003645)2.10418981
85Poor head control (HP:0002421)2.10259291
86Chronic otitis media (HP:0000389)2.09820506
87Renal cortical cysts (HP:0000803)2.09263137
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07100937
89Abnormality of B cell number (HP:0010975)2.06785790
90B lymphocytopenia (HP:0010976)2.06785790
91Generalized aminoaciduria (HP:0002909)2.06140459
92Abnormality of pyrimidine metabolism (HP:0004353)2.06082070
93Abnormality of T cell physiology (HP:0011840)2.05644188
94Abnormal rod and cone electroretinograms (HP:0008323)2.05364013
95Broad-based gait (HP:0002136)2.04653483
96Abnormality of alanine metabolism (HP:0010916)2.02805424
97Hyperalaninemia (HP:0003348)2.02805424
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02805424
99Abnormality of chromosome stability (HP:0003220)2.02161733
100Abnormality of the preputium (HP:0100587)2.01418514
101Limb dystonia (HP:0002451)2.01284804
102Abnormality of DNA repair (HP:0003254)2.00069402
103Respiratory failure (HP:0002878)1.99976255
104Granulocytopenia (HP:0001913)1.99173390
105Abnormal delayed hypersensitivity skin test (HP:0002963)1.99092891
106Anophthalmia (HP:0000528)1.98218432
107Patellar aplasia (HP:0006443)1.97292266
108Optic nerve hypoplasia (HP:0000609)1.97139022
109Lissencephaly (HP:0001339)1.96945378
110Increased muscle lipid content (HP:0009058)1.96769904
111Male pseudohermaphroditism (HP:0000037)1.94632804
112Myelodysplasia (HP:0002863)1.94100409
113Microcytic anemia (HP:0001935)1.93995818
114Bone marrow hypocellularity (HP:0005528)1.92876175
115Agnosia (HP:0010524)1.91657997
116Abnormality of the prostate (HP:0008775)1.91449660
117Abnormal hair whorl (HP:0010721)1.91016426
118Hyperventilation (HP:0002883)1.90983537
119Intestinal atresia (HP:0011100)1.90278999
120Progressive external ophthalmoplegia (HP:0000590)1.89434068
121Mediastinal lymphadenopathy (HP:0100721)1.88593376
122Joint hemorrhage (HP:0005261)1.87615619
123Aplasia/Hypoplasia of the patella (HP:0006498)1.87393096
124Oligodactyly (hands) (HP:0001180)1.87237867
125Abnormality of the ileum (HP:0001549)1.87199674
126Abolished electroretinogram (ERG) (HP:0000550)1.87095191
127Postaxial foot polydactyly (HP:0001830)1.86697583
128Clubbing of toes (HP:0100760)1.86213038
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86084690
130Myositis (HP:0100614)1.86041980
131Attenuation of retinal blood vessels (HP:0007843)1.85328959
132Abnormality of renal resorption (HP:0011038)1.85213902
133Meckel diverticulum (HP:0002245)1.85106064
134Severe visual impairment (HP:0001141)1.84685678
135Lymphoma (HP:0002665)1.83333391
136Hyperbilirubinemia (HP:0002904)1.80941840
137Absent thumb (HP:0009777)1.80582525
138Epistaxis (HP:0000421)1.80575959
139Poor coordination (HP:0002370)1.79787865
140Aplasia/Hypoplasia of the uvula (HP:0010293)1.79032631
141Aplasia/Hypoplasia of the tongue (HP:0010295)1.78832542
142Recurrent bronchitis (HP:0002837)1.78219535
143CNS demyelination (HP:0007305)1.77997735
144Postaxial hand polydactyly (HP:0001162)1.77984336
145Leukodystrophy (HP:0002415)1.76410381
146Congenital hepatic fibrosis (HP:0002612)1.76129498
147Vacuolated lymphocytes (HP:0001922)1.75928751
148Duplicated collecting system (HP:0000081)1.75844792
149Prolonged neonatal jaundice (HP:0006579)1.75801904
150Purpura (HP:0000979)1.75595630
151Retinal dysplasia (HP:0007973)1.75040170
152Recurrent skin infections (HP:0001581)1.74890309
153Cerebellar dysplasia (HP:0007033)1.74807974
154Hyperglycinuria (HP:0003108)1.74787958
155Large for gestational age (HP:0001520)1.74333447
156Methylmalonic aciduria (HP:0012120)1.73963253
157Preaxial hand polydactyly (HP:0001177)1.72735926
158Hypochromic anemia (HP:0001931)1.72707824
159Amaurosis fugax (HP:0100576)1.72705982
160Focal motor seizures (HP:0011153)1.71886533
161Concave nail (HP:0001598)1.69883734
162Stenosis of the external auditory canal (HP:0000402)1.69216856
163Inability to walk (HP:0002540)1.69166813
164Pachygyria (HP:0001302)1.68550293
165Abnormal biliary tract physiology (HP:0012439)1.68013060
166Bile duct proliferation (HP:0001408)1.68013060
167Glycosuria (HP:0003076)1.67418558
168Abnormality of urine glucose concentration (HP:0011016)1.67418558
169Triphalangeal thumb (HP:0001199)1.67337587
170Myokymia (HP:0002411)1.66642773
171Progressive cerebellar ataxia (HP:0002073)1.65325033
172Abnormal respiratory epithelium morphology (HP:0012253)1.63940759
173Abnormal respiratory motile cilium morphology (HP:0005938)1.63940759
174Specific learning disability (HP:0001328)1.63923591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.98171425
2FRK3.12228252
3WNK32.83326441
4EIF2AK12.78195605
5NME22.77554762
6BUB12.75852923
7CASK2.75059733
8VRK12.52344588
9PIM22.52037863
10DYRK22.30522047
11MAP3K122.29060837
12EIF2AK32.26284204
13MARK12.18615664
14NUAK12.16662010
15MAP4K22.11874040
16MAP3K42.06863019
17BRSK22.06317747
18VRK22.05428055
19MAP3K142.05067259
20IRAK42.04551562
21GRK11.92446856
22WEE11.92343500
23TEC1.79901575
24KIT1.77674215
25MAPK131.71126467
26IRAK31.61237282
27MKNK21.58456699
28TYK21.57537653
29IKBKB1.57320313
30SRPK11.54893008
31MAP4K11.54752650
32PINK11.53715000
33TRIM281.49288544
34TNIK1.49199552
35INSRR1.45437845
36TXK1.44659553
37ZAK1.44008149
38BLK1.43398455
39WNK41.42676403
40PNCK1.41670862
41EIF2AK21.35546483
42CDC71.33193311
43PLK41.31617815
44EPHA41.27448176
45TLK11.22681028
46CSNK1G21.22480677
47MYLK1.18353100
48PRKCG1.18212713
49BTK1.17270965
50IKBKE1.16733976
51TBK11.15741315
52GRK71.15284482
53FLT31.15202771
54ADRBK21.14892207
55CSF1R1.13857083
56CSNK1G11.13357680
57ACVR1B1.12998656
58CSNK1G31.11529239
59JAK31.07710978
60PAK31.06064627
61MST41.05404634
62SYK1.04634079
63PIM11.04097826
64ATR1.03146663
65NTRK21.03015570
66MUSK1.02449313
67OXSR11.02377046
68FGFR20.99729494
69CSNK1A1L0.98332874
70ZAP700.96586408
71TSSK60.96117059
72BRSK10.95691017
73YES10.94748455
74MAPK150.93618903
75ARAF0.93274141
76PBK0.91950741
77STK40.89723991
78CDK190.89161997
79CCNB10.88926967
80LYN0.86465970
81PHKG10.84121826
82PHKG20.84121826
83BRAF0.83841749
84CHUK0.80903368
85SIK20.79577735
86TAF10.79559223
87SIK30.78132524
88TGFBR20.77968075
89BMPR20.77959341
90PLK20.74358512
91ABL20.74128716
92TAOK30.73182230
93MAP3K110.72381468
94CLK10.72246676
95ADRBK10.71888466
96NTRK30.71332512
97STK390.71032273
98IRAK10.70136434
99FES0.69920286
100CDK70.69137402
101PLK10.69117444
102NEK20.68696685
103CSNK2A10.68062400
104DAPK10.67928835
105NLK0.67206220
106IRAK20.66936363
107DAPK20.66912483
108EPHB20.66656084
109DYRK30.65437092
110STK38L0.65284608
111MAP2K40.65129810
112STK240.64926194
113PRKCE0.63532149
114AURKB0.62386676
115CDK30.61539727
116MKNK10.59836413
117KDR0.57896380
118GRK60.57579275
119PASK0.56844655
120NEK90.56735782
121RPS6KA50.56585593
122NME10.56381129
123PLK30.55469969
124DYRK1A0.55224663
125MAP2K70.54847463
126OBSCN0.54100954
127LCK0.54090192
128ERBB30.52270546
129MINK10.52029304
130AURKA0.51898086
131UHMK10.51861189
132CSNK1E0.50678848
133BCKDK0.49903116
134BMPR1B0.49519778
135CSNK2A20.49471534
136PRKACA0.49326153
137CSNK1A10.48695158
138ATM0.48618974
139CHEK20.48596050
140RPS6KA40.46992858
141CAMKK20.46778988
142CDK80.46453347
143EPHA30.46425014
144CAMK10.46084410
145TIE10.45807691
146PKN10.45146075
147PRKCD0.45077021
148CSNK1D0.44762308
149MAPKAPK50.42625995
150CAMK2A0.41188668
151GRK50.39767783
152BCR0.39519801
153MAPK40.36799583
154PIK3CA0.36406318
155SGK2230.35968036
156SGK4940.35968036
157STK110.35638724
158MAP3K30.35619334
159PRKACB0.35313368
160TGFBR10.35105641
161RPS6KA60.33701784
162RPS6KB10.33124028
163PAK40.32955112

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.98491069
2Proteasome_Homo sapiens_hsa030503.92839481
3Ribosome_Homo sapiens_hsa030103.66447889
4RNA polymerase_Homo sapiens_hsa030203.23499096
5Mismatch repair_Homo sapiens_hsa034303.15271486
6Base excision repair_Homo sapiens_hsa034102.71933664
7Homologous recombination_Homo sapiens_hsa034402.50164721
8Pyrimidine metabolism_Homo sapiens_hsa002402.50013502
9Oxidative phosphorylation_Homo sapiens_hsa001902.40425828
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.40226764
11Nucleotide excision repair_Homo sapiens_hsa034202.23617714
12Protein export_Homo sapiens_hsa030602.22539117
13Parkinsons disease_Homo sapiens_hsa050122.21660569
14Cardiac muscle contraction_Homo sapiens_hsa042602.19455886
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18826881
16Nicotine addiction_Homo sapiens_hsa050332.08242041
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97880248
18Phototransduction_Homo sapiens_hsa047441.93922643
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.93038639
20Fanconi anemia pathway_Homo sapiens_hsa034601.91611469
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90358986
22Spliceosome_Homo sapiens_hsa030401.88746052
23Butanoate metabolism_Homo sapiens_hsa006501.70173533
24Allograft rejection_Homo sapiens_hsa053301.64775307
25Huntingtons disease_Homo sapiens_hsa050161.63189510
26One carbon pool by folate_Homo sapiens_hsa006701.61869916
27Purine metabolism_Homo sapiens_hsa002301.47277402
28Non-homologous end-joining_Homo sapiens_hsa034501.43923709
29Nitrogen metabolism_Homo sapiens_hsa009101.42777879
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.39629935
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39088041
32Alzheimers disease_Homo sapiens_hsa050101.37573067
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36054111
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34775701
35Basal transcription factors_Homo sapiens_hsa030221.32872635
36Linoleic acid metabolism_Homo sapiens_hsa005911.32064262
37RNA degradation_Homo sapiens_hsa030181.26689175
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26050237
39Propanoate metabolism_Homo sapiens_hsa006401.24962443
40RNA transport_Homo sapiens_hsa030131.24894875
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22940308
42Primary immunodeficiency_Homo sapiens_hsa053401.20404263
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18190648
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17844321
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17452717
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15715477
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.14148294
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13281945
49Graft-versus-host disease_Homo sapiens_hsa053321.10099279
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09236001
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.08713100
52Vitamin B6 metabolism_Homo sapiens_hsa007501.04459453
53SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02298707
54Herpes simplex infection_Homo sapiens_hsa051681.01572195
55Cell cycle_Homo sapiens_hsa041101.01282484
56Measles_Homo sapiens_hsa051621.00932256
57Tryptophan metabolism_Homo sapiens_hsa003800.99850669
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97874075
59Taste transduction_Homo sapiens_hsa047420.97321933
60Folate biosynthesis_Homo sapiens_hsa007900.94758794
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.94026574
62Antigen processing and presentation_Homo sapiens_hsa046120.92103844
63Autoimmune thyroid disease_Homo sapiens_hsa053200.90527978
64Basal cell carcinoma_Homo sapiens_hsa052170.90407838
65Morphine addiction_Homo sapiens_hsa050320.90354585
66Pentose phosphate pathway_Homo sapiens_hsa000300.89828450
67Ether lipid metabolism_Homo sapiens_hsa005650.89796941
68Systemic lupus erythematosus_Homo sapiens_hsa053220.85961721
69GABAergic synapse_Homo sapiens_hsa047270.84545762
70Hedgehog signaling pathway_Homo sapiens_hsa043400.81574432
71Epstein-Barr virus infection_Homo sapiens_hsa051690.81305944
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.78667322
73Legionellosis_Homo sapiens_hsa051340.78547720
74Olfactory transduction_Homo sapiens_hsa047400.78306885
75Steroid biosynthesis_Homo sapiens_hsa001000.77716829
76Peroxisome_Homo sapiens_hsa041460.76936788
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74904816
78p53 signaling pathway_Homo sapiens_hsa041150.73932765
79Other glycan degradation_Homo sapiens_hsa005110.73436603
80Glutathione metabolism_Homo sapiens_hsa004800.70990815
81Arachidonic acid metabolism_Homo sapiens_hsa005900.70386381
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69774295
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.68328667
84Metabolic pathways_Homo sapiens_hsa011000.68189606
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66129856
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66052717
87Glutamatergic synapse_Homo sapiens_hsa047240.65628183
88Leishmaniasis_Homo sapiens_hsa051400.64180123
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61235224
90Serotonergic synapse_Homo sapiens_hsa047260.60098807
91Rheumatoid arthritis_Homo sapiens_hsa053230.60042686
92Cocaine addiction_Homo sapiens_hsa050300.59817249
93Chemical carcinogenesis_Homo sapiens_hsa052040.59553399
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58889069
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57008426
96Hematopoietic cell lineage_Homo sapiens_hsa046400.56996085
97Circadian entrainment_Homo sapiens_hsa047130.56227803
98Insulin secretion_Homo sapiens_hsa049110.55996016
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.52475542
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51467482
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50668370
102Sulfur relay system_Homo sapiens_hsa041220.50343406
103Caffeine metabolism_Homo sapiens_hsa002320.49899537
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49849668
105Influenza A_Homo sapiens_hsa051640.49201342
106Retinol metabolism_Homo sapiens_hsa008300.47882399
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47797328
108Type I diabetes mellitus_Homo sapiens_hsa049400.47515346
109Pyruvate metabolism_Homo sapiens_hsa006200.46738604
110Dopaminergic synapse_Homo sapiens_hsa047280.46459771
111Asthma_Homo sapiens_hsa053100.45099006
112beta-Alanine metabolism_Homo sapiens_hsa004100.44698068
113Malaria_Homo sapiens_hsa051440.44570314
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43821787
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43797126
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42738282
117Selenocompound metabolism_Homo sapiens_hsa004500.42659387
118Galactose metabolism_Homo sapiens_hsa000520.42498817
119Biosynthesis of amino acids_Homo sapiens_hsa012300.42014673
120Regulation of autophagy_Homo sapiens_hsa041400.41894067
121N-Glycan biosynthesis_Homo sapiens_hsa005100.41861148
122Apoptosis_Homo sapiens_hsa042100.41711767
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41616673
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41453437
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38618852
126Fructose and mannose metabolism_Homo sapiens_hsa000510.38398184
127Fatty acid elongation_Homo sapiens_hsa000620.37655288
128mRNA surveillance pathway_Homo sapiens_hsa030150.37098466
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36793453
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36404335
131Staphylococcus aureus infection_Homo sapiens_hsa051500.36058644
132Pertussis_Homo sapiens_hsa051330.35957674
133Amphetamine addiction_Homo sapiens_hsa050310.34860178
134Carbon metabolism_Homo sapiens_hsa012000.33492548
135Fat digestion and absorption_Homo sapiens_hsa049750.31166187
136Axon guidance_Homo sapiens_hsa043600.30235903
137Phenylalanine metabolism_Homo sapiens_hsa003600.29885560
138Alcoholism_Homo sapiens_hsa050340.29675644
139Collecting duct acid secretion_Homo sapiens_hsa049660.29357240
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29079625
141African trypanosomiasis_Homo sapiens_hsa051430.28831745
142Phagosome_Homo sapiens_hsa041450.28666694
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28412019
144Complement and coagulation cascades_Homo sapiens_hsa046100.26821258
145Calcium signaling pathway_Homo sapiens_hsa040200.26687280
146Tyrosine metabolism_Homo sapiens_hsa003500.26212391
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.24810140
148Hippo signaling pathway_Homo sapiens_hsa043900.24681813
149Glycerolipid metabolism_Homo sapiens_hsa005610.24647439
150Vitamin digestion and absorption_Homo sapiens_hsa049770.23867599

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