RPAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)6.55301356
2daunorubicin metabolic process (GO:0044597)6.55301356
3polyketide metabolic process (GO:0030638)6.55301356
4protein localization to kinetochore (GO:0034501)6.01298091
5regulation of nuclear cell cycle DNA replication (GO:0033262)5.39060839
6DNA replication-dependent nucleosome assembly (GO:0006335)4.99963108
7DNA replication-dependent nucleosome organization (GO:0034723)4.99963108
8nuclear pore complex assembly (GO:0051292)4.95164267
9histone H4-K12 acetylation (GO:0043983)4.93856183
10heterochromatin organization (GO:0070828)4.88594759
11regulation of telomere maintenance via telomerase (GO:0032210)4.88541907
12mitotic sister chromatid segregation (GO:0000070)4.86582760
13protein localization to chromosome, centromeric region (GO:0071459)4.81022064
14nuclear pore organization (GO:0006999)4.74757140
15negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.68106693
16histone H4-K5 acetylation (GO:0043981)4.55865911
17histone H4-K8 acetylation (GO:0043982)4.55865911
18maintenance of protein location in nucleus (GO:0051457)4.52202032
19DNA replication checkpoint (GO:0000076)4.50517222
20regulation of gene silencing by RNA (GO:0060966)4.46085194
21regulation of posttranscriptional gene silencing (GO:0060147)4.46085194
22regulation of gene silencing by miRNA (GO:0060964)4.46085194
23regulation of mammary gland epithelial cell proliferation (GO:0033599)4.41912813
24L-serine metabolic process (GO:0006563)4.39247812
25pre-miRNA processing (GO:0031054)4.35441828
26negative regulation of cell cycle G2/M phase transition (GO:1902750)4.35332393
27negative regulation of telomerase activity (GO:0051974)4.30247789
28negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.28135508
29DNA unwinding involved in DNA replication (GO:0006268)4.27899868
30negative regulation of epidermis development (GO:0045683)4.23479928
31sister chromatid segregation (GO:0000819)4.22299955
32formation of translation preinitiation complex (GO:0001731)4.18197758
33rRNA transcription (GO:0009303)4.17702831
34somite rostral/caudal axis specification (GO:0032525)4.15224154
35aminoglycoside antibiotic metabolic process (GO:0030647)4.08174143
36chromatin assembly (GO:0031497)4.07576270
37histone H2A acetylation (GO:0043968)4.07355893
38rRNA methylation (GO:0031167)3.86450439
39regulation of translation in response to stress (GO:0043555)3.86142380
40rRNA modification (GO:0000154)3.85127692
41regulation of translational fidelity (GO:0006450)3.84935623
42DNA duplex unwinding (GO:0032508)3.82276700
43muscle organ morphogenesis (GO:0048644)3.80465353
44DNA geometric change (GO:0032392)3.80009184
45DNA replication initiation (GO:0006270)3.77060720
46ribosome biogenesis (GO:0042254)3.75016284
47establishment of integrated proviral latency (GO:0075713)3.71734533
48positive regulation of DNA-dependent DNA replication (GO:2000105)3.70578443
49pore complex assembly (GO:0046931)3.67367981
50notochord development (GO:0030903)3.64944176
51mitotic nuclear envelope disassembly (GO:0007077)3.64425016
52regulation of response to osmotic stress (GO:0047484)3.61473777
53mitotic chromosome condensation (GO:0007076)3.58256406
54telomere maintenance via semi-conservative replication (GO:0032201)3.49783873
55negative regulation of telomere maintenance (GO:0032205)3.45936433
56peptidyl-arginine omega-N-methylation (GO:0035247)3.43838791
57IMP metabolic process (GO:0046040)3.39564791
58histone H4-K16 acetylation (GO:0043984)3.37642968
59negative regulation of epidermal cell differentiation (GO:0045605)3.35934626
60nuclear envelope disassembly (GO:0051081)3.35554619
61membrane disassembly (GO:0030397)3.35554619
62spliceosomal snRNP assembly (GO:0000387)3.33000594
63ribosomal small subunit biogenesis (GO:0042274)3.30281714
64tRNA aminoacylation for protein translation (GO:0006418)3.26129923
65DNA strand renaturation (GO:0000733)3.26074017
66regulation of MHC class I biosynthetic process (GO:0045343)3.24530490
67pseudouridine synthesis (GO:0001522)3.22277572
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21965944
69RNA stabilization (GO:0043489)3.21569827
70mRNA stabilization (GO:0048255)3.21569827
71negative regulation of gene silencing (GO:0060969)3.20177660
72tRNA aminoacylation (GO:0043039)3.19935537
73amino acid activation (GO:0043038)3.19935537
74trophectodermal cell differentiation (GO:0001829)3.16525625
75ribonucleoprotein complex biogenesis (GO:0022613)3.16046847
76purine nucleobase biosynthetic process (GO:0009113)3.15691674
77chromatin remodeling at centromere (GO:0031055)3.12823629
78peptidyl-arginine methylation (GO:0018216)3.12210630
79peptidyl-arginine N-methylation (GO:0035246)3.12210630
80primitive streak formation (GO:0090009)3.11798639
81somatic hypermutation of immunoglobulin genes (GO:0016446)3.11055378
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.11055378
83non-recombinational repair (GO:0000726)3.10355747
84double-strand break repair via nonhomologous end joining (GO:0006303)3.10355747
85histone arginine methylation (GO:0034969)3.06997697
86folic acid-containing compound biosynthetic process (GO:0009396)3.06615985
87mitochondrial DNA replication (GO:0006264)3.06471729
88negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05825733
89regulation of gene silencing (GO:0060968)3.03683911
90nucleoside transmembrane transport (GO:1901642)3.03472196
91cullin deneddylation (GO:0010388)3.03074373
92DNA conformation change (GO:0071103)3.02875999
93mitochondrial DNA metabolic process (GO:0032042)3.01730796
94branching involved in mammary gland duct morphogenesis (GO:0060444)3.01496893
95intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.01448272
96transcription from mitochondrial promoter (GO:0006390)3.00553953
97CENP-A containing nucleosome assembly (GO:0034080)2.97901879
98DNA strand elongation involved in DNA replication (GO:0006271)2.97600699
99IMP biosynthetic process (GO:0006188)2.97490949
100mitochondrial RNA metabolic process (GO:0000959)2.95604259
101cell fate commitment involved in formation of primary germ layer (GO:0060795)2.95227097
102serine family amino acid biosynthetic process (GO:0009070)2.95207824
103base-excision repair (GO:0006284)2.94500896
104nucleobase biosynthetic process (GO:0046112)2.93368744
105DNA damage response, detection of DNA damage (GO:0042769)2.92768415
106chromatin assembly or disassembly (GO:0006333)2.92482538
107intestinal epithelial cell development (GO:0060576)2.91201322
108intracellular estrogen receptor signaling pathway (GO:0030520)2.90876451
109spindle assembly (GO:0051225)2.90787624
110pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.90518609
111regulation of double-strand break repair (GO:2000779)2.89854566
112regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.89025652
113regulation of DNA-dependent DNA replication (GO:0090329)2.88738033
114pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.87764611
115negative regulation of mRNA processing (GO:0050686)2.87416937
116mitotic recombination (GO:0006312)2.86888014
117telomere maintenance via recombination (GO:0000722)2.86681411
118regulation of telomere maintenance (GO:0032204)2.86554324
119negative regulation of histone methylation (GO:0031061)2.85971235
120regulation of apoptotic process involved in morphogenesis (GO:1902337)2.85059276
121mitotic metaphase plate congression (GO:0007080)2.83942845
122maturation of 5.8S rRNA (GO:0000460)2.83686077
123regulation of histone H3-K9 methylation (GO:0051570)2.83342062
124attachment of spindle microtubules to kinetochore (GO:0008608)2.82564232
125DNA strand elongation (GO:0022616)2.81231315
126DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.80946633
127DNA replication-independent nucleosome organization (GO:0034724)2.79273684
128DNA replication-independent nucleosome assembly (GO:0006336)2.79273684
129metaphase plate congression (GO:0051310)2.78028864
130nucleosome disassembly (GO:0006337)2.77442954
131protein-DNA complex disassembly (GO:0032986)2.77442954
132protein localization to chromosome (GO:0034502)2.76272159
133pteridine-containing compound biosynthetic process (GO:0042559)2.75622658
134pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.75390766
135snRNA processing (GO:0016180)2.75139858
136regulation of cilium movement (GO:0003352)2.74286682
137establishment of viral latency (GO:0019043)2.72622180
138pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72584605
139spliceosomal tri-snRNP complex assembly (GO:0000244)2.68944316
140positive regulation of chromosome segregation (GO:0051984)2.68369349
141regulation of mitotic spindle checkpoint (GO:1903504)2.66814907
142regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66814907
143establishment of protein localization to mitochondrial membrane (GO:0090151)2.66670917
144termination of RNA polymerase II transcription (GO:0006369)2.66318609
145telomere maintenance via telomere lengthening (GO:0010833)2.65351654
146protein complex localization (GO:0031503)2.65161411
147protein deneddylation (GO:0000338)2.64814525
148snRNA metabolic process (GO:0016073)2.64721984
149regulation of spindle checkpoint (GO:0090231)2.63514858
150mRNA cleavage (GO:0006379)2.63143567
151regulation of sister chromatid cohesion (GO:0007063)2.62385982
152negative regulation of mRNA metabolic process (GO:1903312)2.62355950
153nuclear envelope organization (GO:0006998)2.60510798
154DNA topological change (GO:0006265)2.57849817
155ATP-dependent chromatin remodeling (GO:0043044)2.56628917
156regulation of spindle organization (GO:0090224)2.55738240
157transcription-coupled nucleotide-excision repair (GO:0006283)2.55632168
158glutamine metabolic process (GO:0006541)2.55408988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.89112355
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.59008818
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.59008818
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.59008818
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.42462900
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.20161706
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16402340
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.04011895
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.71787233
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.71648492
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63761018
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57783880
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52184956
14* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.51394227
15* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.42879560
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.41711321
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26099663
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14608044
19SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.13289836
20NANOG_18555785_ChIP-Seq_MESCs_Mouse2.08779585
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08448962
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04292196
23* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.02938408
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98649688
25* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.97834685
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96632024
27MYC_22102868_ChIP-Seq_BL_Human1.95383542
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.94202307
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.86364968
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86075278
31* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80617231
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79782287
33* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78418405
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.78240192
35* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.77960172
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76737105
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76680727
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.73300641
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66607647
40* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.62138160
41* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.61426716
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60668939
43* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59011992
44SOX2_18555785_ChIP-Seq_MESCs_Mouse1.58553279
45XRN2_22483619_ChIP-Seq_HELA_Human1.58312310
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.56976847
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.55027902
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.54536575
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53563761
50* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52002393
51* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51952862
52* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50286332
53* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49737650
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.49285617
55* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.47250023
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42948714
57CIITA_25753668_ChIP-Seq_RAJI_Human1.41728196
58MYC_18940864_ChIP-ChIP_HL60_Human1.41347726
59* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.41134339
60ELK1_19687146_ChIP-ChIP_HELA_Human1.40943594
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40481080
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36081400
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32540770
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.32115909
65ZNF263_19887448_ChIP-Seq_K562_Human1.31646880
66FOXP3_21729870_ChIP-Seq_TREG_Human1.31179621
67* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30371463
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30322136
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27579766
70OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25250325
71* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.23654664
72NANOG_21062744_ChIP-ChIP_HESCs_Human1.21750178
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21740086
74TTF2_22483619_ChIP-Seq_HELA_Human1.20590310
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19620839
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.18827985
77* GABP_17652178_ChIP-ChIP_JURKAT_Human1.18770798
78* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.18122613
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17769640
80KDM5A_27292631_Chip-Seq_BREAST_Human1.17531352
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.16493034
82AR_21909140_ChIP-Seq_LNCAP_Human1.16485632
83* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16411173
84* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16384273
85VDR_23849224_ChIP-Seq_CD4+_Human1.16356101
86IRF1_19129219_ChIP-ChIP_H3396_Human1.15637785
87* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14951096
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14870687
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.14020545
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.13628759
91* GABP_19822575_ChIP-Seq_HepG2_Human1.13588010
92* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.13510894
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13113298
94* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.13100252
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12699570
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12097966
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11596417
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10923703
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10790047
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10766578
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10044866
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07393924
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06486593
104* FOXP1_21924763_ChIP-Seq_HESCs_Human1.05372894
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03919803
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02444832
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02112792
108DCP1A_22483619_ChIP-Seq_HELA_Human1.01213007
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00001346
110ZNF274_21170338_ChIP-Seq_K562_Hela0.99780059
111* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98200997
112CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97394152
113PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96772749
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96598653
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95121425
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94606495
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94262342
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93404059
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92814635
120* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92713107
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92151193
122ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92121417
123TFEB_21752829_ChIP-Seq_HELA_Human0.91316339
124* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90290384
125NCOR1_26117541_ChIP-Seq_K562_Human0.89720292
126TCF7_22412390_ChIP-Seq_EML_Mouse0.89278784
127VDR_21846776_ChIP-Seq_THP-1_Human0.87341949
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86927051
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86543138
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.85679237
131KAP1_27257070_Chip-Seq_ESCs_Mouse0.85454565
132* NANOG_16518401_ChIP-PET_MESCs_Mouse0.83549695
133E2F1_17053090_ChIP-ChIP_MCF-7_Human0.83390897
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83108859
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.81253185
136SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80265940
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79333165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.11727934
2MP0004957_abnormal_blastocyst_morpholog3.90063900
3MP0004264_abnormal_extraembryonic_tissu3.49189647
4MP0006292_abnormal_olfactory_placode3.14269209
5MP0003890_abnormal_embryonic-extraembry3.11609868
6MP0003111_abnormal_nucleus_morphology2.92311229
7MP0010094_abnormal_chromosome_stability2.90063111
8MP0003077_abnormal_cell_cycle2.84309775
9MP0002254_reproductive_system_inflammat2.62874629
10MP0010352_gastrointestinal_tract_polyps2.61771343
11MP0003693_abnormal_embryo_hatching2.61705655
12MP0005075_abnormal_melanosome_morpholog2.44942028
13MP0003011_delayed_dark_adaptation2.38767405
14MP0002653_abnormal_ependyma_morphology2.37224644
15MP0003121_genomic_imprinting2.27133120
16MP0001672_abnormal_embryogenesis/_devel2.22493236
17MP0005380_embryogenesis_phenotype2.22493236
18MP0003136_yellow_coat_color2.16823014
19MP0000350_abnormal_cell_proliferation2.10269864
20MP0003123_paternal_imprinting2.07388922
21MP0009672_abnormal_birth_weight2.06539752
22MP0003705_abnormal_hypodermis_morpholog2.04761653
23MP0005394_taste/olfaction_phenotype2.04632803
24MP0005499_abnormal_olfactory_system2.04632803
25MP0003984_embryonic_growth_retardation2.02730087
26MP0002088_abnormal_embryonic_growth/wei2.01935098
27MP0003122_maternal_imprinting1.98562904
28MP0001730_embryonic_growth_arrest1.92426505
29MP0010030_abnormal_orbit_morphology1.86029190
30MP0002085_abnormal_embryonic_tissue1.80578708
31MP0003718_maternal_effect1.75997996
32MP0008932_abnormal_embryonic_tissue1.74358459
33MP0008058_abnormal_DNA_repair1.74327438
34MP0002086_abnormal_extraembryonic_tissu1.71862994
35MP0002084_abnormal_developmental_patter1.71591387
36MP0003567_abnormal_fetal_cardiomyocyte1.70787625
37MP0002938_white_spotting1.69768126
38MP0002396_abnormal_hematopoietic_system1.68316124
39MP0001293_anophthalmia1.67093012
40MP0004233_abnormal_muscle_weight1.64790445
41MP0008007_abnormal_cellular_replicative1.62168127
42MP0005257_abnormal_intraocular_pressure1.60019915
43MP0004133_heterotaxia1.59925273
44MP0004858_abnormal_nervous_system1.58522930
45MP0002332_abnormal_exercise_endurance1.58505333
46MP0003941_abnormal_skin_development1.55718032
47MP0001697_abnormal_embryo_size1.53957432
48MP0004197_abnormal_fetal_growth/weight/1.53824331
49MP0000537_abnormal_urethra_morphology1.53179975
50MP0000678_abnormal_parathyroid_gland1.52823313
51MP0000372_irregular_coat_pigmentation1.52441104
52MP0003119_abnormal_digestive_system1.49489958
53MP0005377_hearing/vestibular/ear_phenot1.48255940
54MP0003878_abnormal_ear_physiology1.48255940
55MP0006035_abnormal_mitochondrial_morpho1.47381185
56MP0001849_ear_inflammation1.43061241
57MP0002080_prenatal_lethality1.40411796
58MP0000751_myopathy1.36352679
59MP0003283_abnormal_digestive_organ1.32078590
60MP0000490_abnormal_crypts_of1.32045595
61MP0000313_abnormal_cell_death1.31706895
62MP0008961_abnormal_basal_metabolism1.27525738
63MP0002127_abnormal_cardiovascular_syste1.26435212
64MP0001661_extended_life_span1.25334418
65MP0003646_muscle_fatigue1.25187026
66MP0002092_abnormal_eye_morphology1.24558354
67MP0009697_abnormal_copulation1.24365747
68MP0005171_absent_coat_pigmentation1.19826875
69MP0003315_abnormal_perineum_morphology1.19668472
70MP0002932_abnormal_joint_morphology1.16706498
71MP0003786_premature_aging1.16512050
72MP0000049_abnormal_middle_ear1.15231838
73MP0003943_abnormal_hepatobiliary_system1.12572457
74MP0000428_abnormal_craniofacial_morphol1.12343733
75MP0003938_abnormal_ear_development1.05718406
76MP0005266_abnormal_metabolism1.05213731
77MP0002019_abnormal_tumor_incidence1.00533153
78MP0002277_abnormal_respiratory_mucosa0.99989198
79MP0003787_abnormal_imprinting0.99483311
80MP0003935_abnormal_craniofacial_develop0.99410750
81MP0000762_abnormal_tongue_morphology0.98680630
82MP0000432_abnormal_head_morphology0.98395480
83MP0002102_abnormal_ear_morphology0.96551611
84MP0004147_increased_porphyrin_level0.95638365
85MP0000566_synostosis0.94301160
86MP0002114_abnormal_axial_skeleton0.94016261
87MP0005076_abnormal_cell_differentiation0.92880903
88MP0003942_abnormal_urinary_system0.92606322
89MP0009703_decreased_birth_body0.91352062
90MP0002925_abnormal_cardiovascular_devel0.90525015
91MP0006072_abnormal_retinal_apoptosis0.90399279
92MP0003385_abnormal_body_wall0.89763985
93MP0002233_abnormal_nose_morphology0.89353761
94MP0008789_abnormal_olfactory_epithelium0.88698267
95MP0005023_abnormal_wound_healing0.84865468
96MP0003755_abnormal_palate_morphology0.84812013
97MP0004145_abnormal_muscle_electrophysio0.84719989
98MP0001348_abnormal_lacrimal_gland0.83162551
99MP0002751_abnormal_autonomic_nervous0.83000972
100MP0008770_decreased_survivor_rate0.82998363
101MP0002111_abnormal_tail_morphology0.82770060
102MP0001764_abnormal_homeostasis0.82473010
103MP0001286_abnormal_eye_development0.81920052
104MP0005330_cardiomyopathy0.80529467
105MP0003937_abnormal_limbs/digits/tail_de0.80113405
106MP0008995_early_reproductive_senescence0.79060297
107MP0002249_abnormal_larynx_morphology0.78881210
108MP0001145_abnormal_male_reproductive0.78794951
109MP0006036_abnormal_mitochondrial_physio0.78578838
110MP0002877_abnormal_melanocyte_morpholog0.78119218
111MP0002970_abnormal_white_adipose0.78023488
112MP0001529_abnormal_vocalization0.77450429
113MP0000358_abnormal_cell_content/0.74678871
114MP0000703_abnormal_thymus_morphology0.73396313
115MP0003806_abnormal_nucleotide_metabolis0.73270517
116MP0003566_abnormal_cell_adhesion0.72314902
117MP0000579_abnormal_nail_morphology0.72305882
118MP0005384_cellular_phenotype0.72280109
119MP0010307_abnormal_tumor_latency0.72101724
120MP0002269_muscular_atrophy0.72098573
121MP0008877_abnormal_DNA_methylation0.71961534
122MP0000750_abnormal_muscle_regeneration0.70918128
123MP0005391_vision/eye_phenotype0.70836466
124MP0003183_abnormal_peptide_metabolism0.70295819
125MP0002075_abnormal_coat/hair_pigmentati0.69699360
126MP0002106_abnormal_muscle_physiology0.67760709
127MP0003861_abnormal_nervous_system0.67572808
128MP0005647_abnormal_sex_gland0.67310764
129MP0001929_abnormal_gametogenesis0.66890936
130MP0005253_abnormal_eye_physiology0.66816522
131MP0000749_muscle_degeneration0.66514980
132MP0002722_abnormal_immune_system0.66481062
133MP0002116_abnormal_craniofacial_bone0.65792711
134MP0000653_abnormal_sex_gland0.64780468
135MP0000858_altered_metastatic_potential0.64529240
136MP0002210_abnormal_sex_determination0.64459526
137MP0002089_abnormal_postnatal_growth/wei0.62996371
138MP0001299_abnormal_eye_distance/0.61559458
139MP0002697_abnormal_eye_size0.61309647
140MP0003186_abnormal_redox_activity0.59067928
141MP0005501_abnormal_skin_physiology0.58977632

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.64003414
2Ependymoma (HP:0002888)5.16900837
3Multiple enchondromatosis (HP:0005701)4.60212821
4Rib fusion (HP:0000902)4.48495340
5Hypochromic microcytic anemia (HP:0004840)4.46376027
6Abnormality of the lower motor neuron (HP:0002366)4.02073241
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.94316076
8Neoplasm of striated muscle (HP:0009728)3.92493623
9Rhabdomyosarcoma (HP:0002859)3.87757483
10Hepatoblastoma (HP:0002884)3.73686839
11Chromsome breakage (HP:0040012)3.58705706
12Abnormality of the astrocytes (HP:0100707)3.58571085
13Astrocytoma (HP:0009592)3.58571085
14Nephroblastoma (Wilms tumor) (HP:0002667)3.22916833
15Colon cancer (HP:0003003)3.21144320
16Trismus (HP:0000211)3.20667269
17Rectal fistula (HP:0100590)3.18593183
18Rectovaginal fistula (HP:0000143)3.18593183
19Aplasia/hypoplasia of the humerus (HP:0006507)3.05699817
20Medulloblastoma (HP:0002885)3.01261568
21Embryonal renal neoplasm (HP:0011794)3.00682751
22Intestinal fistula (HP:0100819)2.99996664
23Abnormality of the salivary glands (HP:0010286)2.94154487
24Reticulocytopenia (HP:0001896)2.90151799
25Short humerus (HP:0005792)2.89910545
26Glioma (HP:0009733)2.89897310
27Abnormal lung lobation (HP:0002101)2.89147031
28Fused cervical vertebrae (HP:0002949)2.81872434
29Abnormality of glycolysis (HP:0004366)2.81191976
30Supernumerary spleens (HP:0009799)2.80113200
31Meckel diverticulum (HP:0002245)2.77990472
32Impulsivity (HP:0100710)2.75162091
33Poikiloderma (HP:0001029)2.71091698
34Vaginal fistula (HP:0004320)2.70901524
35Preauricular skin tag (HP:0000384)2.67409007
36Abnormality of the ileum (HP:0001549)2.66517484
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.65124393
38Shawl scrotum (HP:0000049)2.64486670
39Cholecystitis (HP:0001082)2.58534082
40Abnormal gallbladder physiology (HP:0012438)2.58534082
41Partial duplication of thumb phalanx (HP:0009944)2.56085725
42Selective tooth agenesis (HP:0001592)2.55930422
43Missing ribs (HP:0000921)2.55580785
44Testicular atrophy (HP:0000029)2.54487656
45Birth length less than 3rd percentile (HP:0003561)2.53544437
46Amyotrophic lateral sclerosis (HP:0007354)2.52505429
47Horseshoe kidney (HP:0000085)2.50461338
48Neoplasm of the oral cavity (HP:0100649)2.49972587
49Skin tags (HP:0010609)2.48231604
50Hypoplasia of the capital femoral epiphysis (HP:0003090)2.45768524
51Ragged-red muscle fibers (HP:0003200)2.43180804
52Bifid tongue (HP:0010297)2.42302660
53Increased serum pyruvate (HP:0003542)2.39839993
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.36866070
55Atrophy/Degeneration involving motor neurons (HP:0007373)2.32795039
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.32476028
57Hypoplasia of the fovea (HP:0007750)2.32476028
58Spinal muscular atrophy (HP:0007269)2.31295614
59Premature ovarian failure (HP:0008209)2.28998834
60Squamous cell carcinoma (HP:0002860)2.25724562
61Partial duplication of the phalanx of hand (HP:0009999)2.24757840
62Supernumerary ribs (HP:0005815)2.24275616
63Large earlobe (HP:0009748)2.22225589
64Renal duplication (HP:0000075)2.22141769
65Abnormality of DNA repair (HP:0003254)2.21623611
66Duodenal stenosis (HP:0100867)2.21318282
67Small intestinal stenosis (HP:0012848)2.21318282
68Hyperinsulinemic hypoglycemia (HP:0000825)2.20973901
69Myopathic facies (HP:0002058)2.20437513
70Hypochromic anemia (HP:0001931)2.19192053
71Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.18867371
72Absent epiphyses (HP:0010577)2.18867371
73Supernumerary bones of the axial skeleton (HP:0009144)2.18501976
74Vertebral fusion (HP:0002948)2.16920510
75Progressive muscle weakness (HP:0003323)2.16237375
76Entropion (HP:0000621)2.14965196
77Atresia of the external auditory canal (HP:0000413)2.14124224
78Ectopic kidney (HP:0000086)2.13803769
79Short 5th finger (HP:0009237)2.12462224
80Abnormality of chromosome segregation (HP:0002916)2.12256324
81Hyperglycinuria (HP:0003108)2.11316607
82Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09427030
83High anterior hairline (HP:0009890)2.05162940
84Glossoptosis (HP:0000162)2.04173059
85Abnormality of the labia minora (HP:0012880)2.03037729
86Horizontal nystagmus (HP:0000666)2.02884633
87Abnormality of the preputium (HP:0100587)2.02859597
88Adenoma sebaceum (HP:0009720)2.02851268
89Angiofibromas (HP:0010615)2.02851268
90Myelodysplasia (HP:0002863)2.02230225
91Absent thumb (HP:0009777)2.01826436
92Abnormality of the anterior horn cell (HP:0006802)1.99695091
93Degeneration of anterior horn cells (HP:0002398)1.99695091
94Abnormal cartilage morphology (HP:0002763)1.98399124
95Pseudobulbar signs (HP:0002200)1.97912982
96Absent forearm bone (HP:0003953)1.97802099
97Absent radius (HP:0003974)1.97333480
98Tongue fasciculations (HP:0001308)1.97278290
99Facial cleft (HP:0002006)1.97203221
100Malignant neoplasm of the central nervous system (HP:0100836)1.97074721
101Carpal bone hypoplasia (HP:0001498)1.97017687
102Retinal dysplasia (HP:0007973)1.96986875
103Neoplasm of the adrenal cortex (HP:0100641)1.96924509
104Hyperglycinemia (HP:0002154)1.96909829
105Abnormality of glycine metabolism (HP:0010895)1.96767584
106Abnormality of serine family amino acid metabolism (HP:0010894)1.96767584
107Aplasia/Hypoplasia of the patella (HP:0006498)1.96362778
108Breast hypoplasia (HP:0003187)1.96334548
109Anomalous pulmonary venous return (HP:0010772)1.95195874
110Sloping forehead (HP:0000340)1.93785918
111Abnormality of the duodenum (HP:0002246)1.92276698
112Abnormality of chromosome stability (HP:0003220)1.91969881
113Volvulus (HP:0002580)1.91516833
114Preauricular pit (HP:0004467)1.90300649
115Periauricular skin pits (HP:0100277)1.90300649
116Abnormal number of erythroid precursors (HP:0012131)1.89907886
117Duplicated collecting system (HP:0000081)1.89387558
118Hepatocellular necrosis (HP:0001404)1.88625326
119Microretrognathia (HP:0000308)1.88129821
120Abnormality of methionine metabolism (HP:0010901)1.87951547
121Cortical dysplasia (HP:0002539)1.87799999
122Pendular nystagmus (HP:0012043)1.87489720
123Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.87452526
124Abnormal number of incisors (HP:0011064)1.87229935
125Neoplasm of the heart (HP:0100544)1.87128265
126Hypopigmentation of the fundus (HP:0007894)1.86343701
127Combined immunodeficiency (HP:0005387)1.86157509
128Abnormality of the distal phalanx of the thumb (HP:0009617)1.86146637
129Pancreatic islet-cell hyperplasia (HP:0004510)1.85908096
130Spastic diplegia (HP:0001264)1.84422767
131Trigonocephaly (HP:0000243)1.82192001
132Increased nuchal translucency (HP:0010880)1.81684293
133Patellar aplasia (HP:0006443)1.81575493
134Microvesicular hepatic steatosis (HP:0001414)1.81507350
135Aplasia involving forearm bones (HP:0009822)1.80969084
136Duplication of thumb phalanx (HP:0009942)1.79278106
137Homocystinuria (HP:0002156)1.78823329
138Abnormality of homocysteine metabolism (HP:0010919)1.78823329
139Hepatic necrosis (HP:0002605)1.66816809
140Broad thumb (HP:0011304)1.66316894
141Hypoplastic pelvis (HP:0008839)1.64093385
142Abnormality of sulfur amino acid metabolism (HP:0004339)1.63777322
143Cerebellar hypoplasia (HP:0001321)1.63196369
144Short thumb (HP:0009778)1.61915703
145Progressive external ophthalmoplegia (HP:0000590)1.61694001
146Impaired proprioception (HP:0010831)1.61392324
147Increased serum lactate (HP:0002151)1.61150961
148Aplasia/Hypoplasia of the breasts (HP:0010311)1.60624138
149Abnormality of the renal collecting system (HP:0004742)1.60482816
150Septo-optic dysplasia (HP:0100842)1.60137852
151Breast aplasia (HP:0100783)1.59241536
152Coarctation of aorta (HP:0001680)1.57977092
153High pitched voice (HP:0001620)1.57286494
154Acute encephalopathy (HP:0006846)1.56944318
155Abnormality of the carotid arteries (HP:0005344)1.55701766
156Pterygium (HP:0001059)1.54395787
157Optic nerve coloboma (HP:0000588)1.53351170
158Overriding aorta (HP:0002623)1.53242288
159Prominent metopic ridge (HP:0005487)1.51864958
160Preaxial hand polydactyly (HP:0001177)1.51454603
161Triphalangeal thumb (HP:0001199)1.51021799
162Dandy-Walker malformation (HP:0001305)1.50589721
163Abnormality of cells of the erythroid lineage (HP:0012130)1.49840167
164Abnormality of the metopic suture (HP:0005556)1.49399747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.31254711
2VRK24.10020973
3ERN13.52599867
4GRK63.33008450
5SMG13.21255458
6GRK53.16984658
7TTK3.15724049
8TRIM282.76310641
9STK102.39114563
10CDC72.34142354
11CDK72.20832431
12CSF1R2.12943056
13PBK2.10749337
14TYRO32.08863610
15EPHA22.07729146
16TAF12.03198377
17WEE12.00616768
18NEK21.98503864
19GRK11.98034559
20ZAK1.86193067
21NME11.84388993
22MAP3K101.82195216
23BUB11.78024798
24ADRBK21.74377760
25PLK11.73040923
26MATK1.69611787
27MAPK71.65084890
28CHEK21.61565109
29TGFBR21.59848306
30PAK41.56957824
31CSNK1G31.41676902
32PLK41.40451874
33RPS6KB21.39231982
34CSNK1A1L1.33431296
35CSNK1G11.31193467
36AKT31.29751447
37CHEK11.24898591
38DYRK21.24758052
39SIK31.23977980
40NEK11.23658483
41WNK31.21995496
42MOS1.21705483
43SRPK11.21302435
44CDK41.21301254
45GRK71.21240976
46FGFR21.20696516
47WNK41.19793992
48WNK11.18530505
49BRD41.11738058
50MKNK21.11609601
51ALK1.10617280
52PDK20.99648737
53BCR0.98701185
54AURKB0.98464881
55STK160.98410699
56TESK20.97263640
57EEF2K0.96524459
58NUAK10.95929162
59MTOR0.95052831
60ATR0.93535253
61CAMK40.92788731
62CAMK1D0.89440364
63AURKA0.89354623
64PASK0.88314758
65CDK190.87615589
66CSNK1G20.86114786
67HIPK20.85656223
68PRKG20.84571665
69* CDK20.83494922
70VRK10.80526396
71DYRK30.79717517
72TLK10.77775735
73AKT20.77466838
74PRKCI0.77085656
75MAP3K80.76642444
76ICK0.75458484
77ATM0.73051492
78RPS6KA40.72826103
79FLT30.72703713
80BMPR1B0.70416490
81STK40.70243799
82TNIK0.69889678
83CAMK1G0.69119486
84MARK20.67935438
85TSSK60.67314721
86BCKDK0.66292410
87MAP4K20.66258398
88ERBB40.64410884
89LATS20.64058133
90PIM20.61396136
91DAPK10.61267321
92TAOK10.60237724
93CSK0.58480707
94TGFBR10.57531130
95BRSK20.55952161
96ADRBK10.54600710
97CDK80.53680902
98PAK10.52384569
99PRKDC0.50436378
100* CDK10.50161707
101FGFR10.47755758
102MST40.47581476
103FGFR30.47050817
104CSNK1E0.46817475
105EIF2AK20.46256493
106MAPKAPK30.42972049
107CDK90.42941479
108NTRK10.42557472
109PIM10.42544703
110PLK30.42342783
111FGFR40.38128299
112CSNK1A10.37785915
113MAP2K60.37613468
114MAP3K70.36716042
115CDK180.35447454
116MAP4K10.35196725
117MAPK10.35018522
118MAPK140.35005185
119RPS6KA10.34952799
120PKN20.34913918
121PINK10.34749819
122CDK11A0.34517635
123PDGFRA0.34307355
124MELK0.34013649
125CDK60.34003473
126NME20.31951970
127BRSK10.31253070
128PRKD30.30891414
129BMX0.30790436
130SIK10.29660319
131CDK150.28759984
132PTK20.28190084
133* GSK3B0.27604107
134ERBB20.26471100
135CSNK2A20.26455459
136CHUK0.26375256
137STK38L0.25370178
138RIPK10.23926003
139ACVR1B0.23534127
140ITK0.22586232
141AKT10.22023923
142EIF2AK10.21399342
143EIF2AK30.20174535
144DYRK1B0.20023027
145CSNK2A10.19452028
146CSNK1D0.17710360
147MKNK10.17260331

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.50292896
2DNA replication_Homo sapiens_hsa030303.90262518
3Mismatch repair_Homo sapiens_hsa034303.73319899
4Vitamin B6 metabolism_Homo sapiens_hsa007503.20044131
5RNA transport_Homo sapiens_hsa030133.10951902
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.98848493
7Spliceosome_Homo sapiens_hsa030402.77650253
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.69979825
9Ribosome_Homo sapiens_hsa030102.66509405
10One carbon pool by folate_Homo sapiens_hsa006702.56670043
11Base excision repair_Homo sapiens_hsa034102.44480603
12Fructose and mannose metabolism_Homo sapiens_hsa000512.42440448
13Homologous recombination_Homo sapiens_hsa034402.37779025
14Cell cycle_Homo sapiens_hsa041102.36305746
15RNA polymerase_Homo sapiens_hsa030202.25611583
16Fanconi anemia pathway_Homo sapiens_hsa034602.20178578
17mRNA surveillance pathway_Homo sapiens_hsa030152.18995805
18Nucleotide excision repair_Homo sapiens_hsa034201.91250891
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86355615
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83948201
21RNA degradation_Homo sapiens_hsa030181.79128367
22Steroid biosynthesis_Homo sapiens_hsa001001.70043960
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69785907
24Galactose metabolism_Homo sapiens_hsa000521.59123865
25Pyruvate metabolism_Homo sapiens_hsa006201.58292046
26Pyrimidine metabolism_Homo sapiens_hsa002401.57282831
27Non-homologous end-joining_Homo sapiens_hsa034501.50979607
28Basal transcription factors_Homo sapiens_hsa030221.45764550
29p53 signaling pathway_Homo sapiens_hsa041151.43198415
30Fatty acid elongation_Homo sapiens_hsa000621.40667628
31Thyroid cancer_Homo sapiens_hsa052161.31690470
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30967730
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30849131
34Propanoate metabolism_Homo sapiens_hsa006401.28995079
35Arachidonic acid metabolism_Homo sapiens_hsa005901.25454198
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24633803
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22855232
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22496679
39mTOR signaling pathway_Homo sapiens_hsa041501.22116493
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22092209
41Basal cell carcinoma_Homo sapiens_hsa052171.15157339
42Proteasome_Homo sapiens_hsa030501.09264482
43Protein export_Homo sapiens_hsa030601.08448251
44Fatty acid metabolism_Homo sapiens_hsa012121.06794176
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03926431
46Parkinsons disease_Homo sapiens_hsa050121.00261486
47Arginine and proline metabolism_Homo sapiens_hsa003300.99026599
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95851156
49Linoleic acid metabolism_Homo sapiens_hsa005910.95602338
50MicroRNAs in cancer_Homo sapiens_hsa052060.94385662
51Biosynthesis of amino acids_Homo sapiens_hsa012300.93616362
52Herpes simplex infection_Homo sapiens_hsa051680.92614659
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91570417
54Notch signaling pathway_Homo sapiens_hsa043300.90998301
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89293382
56Huntingtons disease_Homo sapiens_hsa050160.88016113
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83772323
58Pentose phosphate pathway_Homo sapiens_hsa000300.82024898
59Hedgehog signaling pathway_Homo sapiens_hsa043400.81886450
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.79410993
61Oxidative phosphorylation_Homo sapiens_hsa001900.77985984
62Hippo signaling pathway_Homo sapiens_hsa043900.77365892
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.74743118
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74343201
65Viral carcinogenesis_Homo sapiens_hsa052030.73692068
66Folate biosynthesis_Homo sapiens_hsa007900.73211560
67HTLV-I infection_Homo sapiens_hsa051660.71192237
68Sulfur relay system_Homo sapiens_hsa041220.69915578
69Acute myeloid leukemia_Homo sapiens_hsa052210.66116163
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64982528
71Metabolic pathways_Homo sapiens_hsa011000.64900353
72Pathways in cancer_Homo sapiens_hsa052000.64630412
73Lysine degradation_Homo sapiens_hsa003100.63922412
74Epstein-Barr virus infection_Homo sapiens_hsa051690.63381024
75Selenocompound metabolism_Homo sapiens_hsa004500.62783198
76Carbon metabolism_Homo sapiens_hsa012000.62155069
77Primary immunodeficiency_Homo sapiens_hsa053400.61386189
78Bladder cancer_Homo sapiens_hsa052190.60717038
79Glutathione metabolism_Homo sapiens_hsa004800.60590261
80N-Glycan biosynthesis_Homo sapiens_hsa005100.60100873
81Purine metabolism_Homo sapiens_hsa002300.59628274
82Other glycan degradation_Homo sapiens_hsa005110.58994929
83Oocyte meiosis_Homo sapiens_hsa041140.58341531
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58067346
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57781175
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.56663211
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55980290
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52739435
89Adherens junction_Homo sapiens_hsa045200.49768642
90Butanoate metabolism_Homo sapiens_hsa006500.47655504
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47637034
92Vitamin digestion and absorption_Homo sapiens_hsa049770.47037731
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46409381
94Small cell lung cancer_Homo sapiens_hsa052220.46250444
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46028977
96Wnt signaling pathway_Homo sapiens_hsa043100.45682544
97Peroxisome_Homo sapiens_hsa041460.45556408
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45286465
99Arginine biosynthesis_Homo sapiens_hsa002200.44522811
100Colorectal cancer_Homo sapiens_hsa052100.44190728
101Non-small cell lung cancer_Homo sapiens_hsa052230.43760635
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42591947
103Apoptosis_Homo sapiens_hsa042100.41615034
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41470645
105Antigen processing and presentation_Homo sapiens_hsa046120.41140895
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.39571144
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.38879566
108AMPK signaling pathway_Homo sapiens_hsa041520.35738400
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35673988
110Inositol phosphate metabolism_Homo sapiens_hsa005620.35073068
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34604313
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33322058
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32336054
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.31626425
115Tight junction_Homo sapiens_hsa045300.31383962
116Systemic lupus erythematosus_Homo sapiens_hsa053220.30689910
117Fatty acid degradation_Homo sapiens_hsa000710.30571384
118Alzheimers disease_Homo sapiens_hsa050100.30366817
119Glucagon signaling pathway_Homo sapiens_hsa049220.29780033
120beta-Alanine metabolism_Homo sapiens_hsa004100.29608660
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29259168
122Proteoglycans in cancer_Homo sapiens_hsa052050.27811200
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27128347
124Fat digestion and absorption_Homo sapiens_hsa049750.26504743
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.24869213
126TGF-beta signaling pathway_Homo sapiens_hsa043500.24478542
127Phototransduction_Homo sapiens_hsa047440.24103763
128Cardiac muscle contraction_Homo sapiens_hsa042600.22750801
129HIF-1 signaling pathway_Homo sapiens_hsa040660.21201918
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19878928
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19342049
132Tyrosine metabolism_Homo sapiens_hsa003500.18754467
133Rap1 signaling pathway_Homo sapiens_hsa040150.18021838
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17596477
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17121786
136Chronic myeloid leukemia_Homo sapiens_hsa052200.16551284
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.15509499
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.15179187
139Fatty acid biosynthesis_Homo sapiens_hsa000610.14743985
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14031372
141Choline metabolism in cancer_Homo sapiens_hsa052310.13454089
142Pancreatic cancer_Homo sapiens_hsa052120.13326133

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »