RPAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of pigment cell differentiation (GO:0050932)4.92719709
2positive regulation of developmental pigmentation (GO:0048087)4.89613411
3piRNA metabolic process (GO:0034587)4.73497271
4tryptophan catabolic process (GO:0006569)4.29625402
5indole-containing compound catabolic process (GO:0042436)4.29625402
6indolalkylamine catabolic process (GO:0046218)4.29625402
7negative regulation of translation, ncRNA-mediated (GO:0040033)4.19735051
8regulation of translation, ncRNA-mediated (GO:0045974)4.19735051
9negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.19735051
10kynurenine metabolic process (GO:0070189)4.15452173
11establishment of protein localization to Golgi (GO:0072600)4.10296528
12interkinetic nuclear migration (GO:0022027)4.09767719
13mitotic metaphase plate congression (GO:0007080)4.06083909
14folic acid-containing compound biosynthetic process (GO:0009396)3.99438179
15indolalkylamine metabolic process (GO:0006586)3.98922501
16regulation of hippo signaling (GO:0035330)3.94295586
17rRNA modification (GO:0000154)3.92798181
18rRNA methylation (GO:0031167)3.87372542
19neural tube formation (GO:0001841)3.85126516
20attachment of spindle microtubules to kinetochore (GO:0008608)3.84006755
21regulation of establishment of cell polarity (GO:2000114)3.83194045
22protein K48-linked deubiquitination (GO:0071108)3.82873074
23ribosome assembly (GO:0042255)3.82468201
24signal peptide processing (GO:0006465)3.80370857
25nucleobase biosynthetic process (GO:0046112)3.75316757
26cilium or flagellum-dependent cell motility (GO:0001539)3.68697521
27proteasome assembly (GO:0043248)3.65820506
28IMP metabolic process (GO:0046040)3.64792089
29maturation of 5.8S rRNA (GO:0000460)3.64370168
30formation of translation preinitiation complex (GO:0001731)3.63621374
31tryptophan metabolic process (GO:0006568)3.62139363
32negative regulation of sodium ion transport (GO:0010766)3.59396952
33purine nucleobase biosynthetic process (GO:0009113)3.57475758
34protein deneddylation (GO:0000338)3.57168030
35IMP biosynthetic process (GO:0006188)3.54588138
36regulation of posttranscriptional gene silencing (GO:0060147)3.54543193
37regulation of gene silencing by miRNA (GO:0060964)3.54543193
38regulation of gene silencing by RNA (GO:0060966)3.54543193
39protein localization to kinetochore (GO:0034501)3.53789590
40ribosomal large subunit biogenesis (GO:0042273)3.52901048
41ribosome biogenesis (GO:0042254)3.51357320
42behavioral response to nicotine (GO:0035095)3.50406922
43metaphase plate congression (GO:0051310)3.46108779
44lipid translocation (GO:0034204)3.42303386
45phospholipid translocation (GO:0045332)3.42303386
46regulation of establishment or maintenance of cell polarity (GO:0032878)3.39568657
47maturation of SSU-rRNA (GO:0030490)3.38459603
48binding of sperm to zona pellucida (GO:0007339)3.33262344
49DNA replication initiation (GO:0006270)3.30771564
50positive regulation of chromosome segregation (GO:0051984)3.30281533
51gamma-aminobutyric acid transport (GO:0015812)3.29431714
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.28015641
53cytoplasmic mRNA processing body assembly (GO:0033962)3.25503846
54cellular response to ethanol (GO:0071361)3.25371014
55regulation of sister chromatid cohesion (GO:0007063)3.21181544
56mitotic chromosome condensation (GO:0007076)3.20960852
57CENP-A containing nucleosome assembly (GO:0034080)3.20256569
58negative regulation of systemic arterial blood pressure (GO:0003085)3.19581638
59DNA methylation involved in gamete generation (GO:0043046)3.19293040
60DNA replication-dependent nucleosome organization (GO:0034723)3.19117254
61DNA replication-dependent nucleosome assembly (GO:0006335)3.19117254
62meiotic cell cycle (GO:0051321)3.18195414
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.18143089
64oxidative demethylation (GO:0070989)3.17464071
65negative regulation of protein localization to cell surface (GO:2000009)3.16884045
66establishment of integrated proviral latency (GO:0075713)3.16768670
67male meiosis (GO:0007140)3.16131862
68DNA strand elongation (GO:0022616)3.16060059
69DNA strand elongation involved in DNA replication (GO:0006271)3.15517789
70ribonucleoprotein complex biogenesis (GO:0022613)3.15407066
71DNA unwinding involved in DNA replication (GO:0006268)3.15038822
72DNA replication checkpoint (GO:0000076)3.14348196
73chromatin remodeling at centromere (GO:0031055)3.14246951
74establishment of chromosome localization (GO:0051303)3.12767924
75detection of light stimulus involved in sensory perception (GO:0050962)3.12319194
76detection of light stimulus involved in visual perception (GO:0050908)3.12319194
77rRNA processing (GO:0006364)3.11836126
78pseudouridine synthesis (GO:0001522)3.11588141
79regulation of sarcomere organization (GO:0060297)3.09708732
80indole-containing compound metabolic process (GO:0042430)3.09312915
81histone H3-K4 trimethylation (GO:0080182)3.09249873
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09093961
83protein K11-linked deubiquitination (GO:0035871)3.08707230
84protein localization to chromosome, centromeric region (GO:0071459)3.08439139
85negative regulation of cytosolic calcium ion concentration (GO:0051481)3.07831393
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07019472
87serotonin metabolic process (GO:0042428)3.06506577
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06470435
89regulation of histone H3-K27 methylation (GO:0061085)3.04816952
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02295871
91rRNA metabolic process (GO:0016072)3.01587337
92somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.00418017
93somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.00418017
94isotype switching (GO:0045190)3.00418017
95histone H2A monoubiquitination (GO:0035518)2.99327498
96regulation of spindle organization (GO:0090224)2.99158665
97reflex (GO:0060004)2.98850721
98L-fucose catabolic process (GO:0042355)2.98466044
99fucose catabolic process (GO:0019317)2.98466044
100L-fucose metabolic process (GO:0042354)2.98466044
101ribosomal small subunit assembly (GO:0000028)2.96881143
1027-methylguanosine mRNA capping (GO:0006370)2.96650451
103histone exchange (GO:0043486)2.96173863
104protein K63-linked deubiquitination (GO:0070536)2.95819824
105meiotic chromosome segregation (GO:0045132)2.94888113
106positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94608114
107endosome to melanosome transport (GO:0035646)2.94234363
108endosome to pigment granule transport (GO:0043485)2.94234363
109mitotic nuclear envelope disassembly (GO:0007077)2.93900892
110negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93487026
111cellular response to sterol (GO:0036315)2.92882163
112protein K6-linked ubiquitination (GO:0085020)2.92131242
113folic acid metabolic process (GO:0046655)2.91822904
114monoubiquitinated protein deubiquitination (GO:0035520)2.91187493
115signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.90801360
116intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.90801360
117photoreceptor cell maintenance (GO:0045494)2.90121486
118transcription-coupled nucleotide-excision repair (GO:0006283)2.89567707
119protein targeting to lysosome (GO:0006622)2.89458242
120establishment of protein localization to vacuole (GO:0072666)2.89458242
121protein targeting to vacuole (GO:0006623)2.89458242
122pericardium development (GO:0060039)2.89341553
123DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88913245
124flavonoid metabolic process (GO:0009812)2.87368594
1257-methylguanosine RNA capping (GO:0009452)2.86549739
126RNA capping (GO:0036260)2.86549739
127cullin deneddylation (GO:0010388)2.86484012
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86354099
129signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86354099
130signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86354099
131DNA replication-independent nucleosome organization (GO:0034724)2.85159093
132DNA replication-independent nucleosome assembly (GO:0006336)2.85159093
133regulation of mitotic spindle organization (GO:0060236)2.83994391
134regulation of meiosis I (GO:0060631)2.83449775
135mitotic sister chromatid segregation (GO:0000070)2.83445441
136central nervous system neuron axonogenesis (GO:0021955)2.82938759
137telomere maintenance via recombination (GO:0000722)2.82672664
138sperm-egg recognition (GO:0035036)2.81282677
139primary amino compound metabolic process (GO:1901160)2.80972805
140behavioral response to ethanol (GO:0048149)2.80845793
141synaptic vesicle docking involved in exocytosis (GO:0016081)2.79377852
142regulation of chromosome segregation (GO:0051983)2.79338126
143signal transduction involved in DNA integrity checkpoint (GO:0072401)2.79050133
144signal transduction involved in DNA damage checkpoint (GO:0072422)2.79050133
145appendage development (GO:0048736)2.78565225
146limb development (GO:0060173)2.78565225
147female gamete generation (GO:0007292)2.77864338
148histone H3-K9 methylation (GO:0051567)2.77805170
149peptidyl-histidine modification (GO:0018202)2.77714099
150microtubule anchoring (GO:0034453)2.76649539
151positive regulation of mitotic sister chromatid separation (GO:1901970)2.76390339
152positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76390339
153positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76390339
154cardiovascular system development (GO:0072358)2.75424316
155nuclear envelope disassembly (GO:0051081)2.74052141
156membrane disassembly (GO:0030397)2.74052141
157negative regulation of ligase activity (GO:0051352)2.73681289
158negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73681289
159thyroid hormone metabolic process (GO:0042403)2.73486470
160regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.73416568
161signal transduction involved in cell cycle checkpoint (GO:0072395)2.73095472
162histone H2A ubiquitination (GO:0033522)2.72301134
163mitotic recombination (GO:0006312)2.71018589
164snRNA processing (GO:0016180)2.70753896
165cell cycle G1/S phase transition (GO:0044843)2.70553009
166G1/S transition of mitotic cell cycle (GO:0000082)2.70553009
167gene silencing by RNA (GO:0031047)2.68931126
168membrane depolarization during action potential (GO:0086010)2.68618550
169tachykinin receptor signaling pathway (GO:0007217)2.67901231
170sulfation (GO:0051923)2.67621603
171nucleus localization (GO:0051647)2.67187051
172protein targeting to Golgi (GO:0000042)2.65756749
173neuronal action potential (GO:0019228)2.64330305
174central nervous system projection neuron axonogenesis (GO:0021952)2.64318865
175cellular ketone body metabolic process (GO:0046950)2.62634814
176NAD biosynthetic process (GO:0009435)2.61438546
177retrograde transport, vesicle recycling within Golgi (GO:0000301)2.58413364
178regulation of short-term neuronal synaptic plasticity (GO:0048172)2.56549067
179cilium organization (GO:0044782)2.56329485
180negative regulation of mast cell activation (GO:0033004)2.55574608
181cilium assembly (GO:0042384)2.54536558
182protein prenylation (GO:0018342)2.54460405
183prenylation (GO:0097354)2.54460405
184regulation of developmental pigmentation (GO:0048070)2.54326499
185phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.52612024
186UDP-N-acetylglucosamine metabolic process (GO:0006047)2.52204520
187cerebellar Purkinje cell differentiation (GO:0021702)2.49578259
188negative regulation of keratinocyte proliferation (GO:0010839)2.48894811
189G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48280515
190peptidyl-lysine methylation (GO:0018022)2.47584561
191cAMP catabolic process (GO:0006198)2.43678469
192cilium movement (GO:0003341)2.43242775
193detection of mechanical stimulus involved in sensory perception (GO:0050974)2.42878993
194cilium morphogenesis (GO:0060271)2.42599318
195glucocorticoid receptor signaling pathway (GO:0042921)2.42387239
196amine catabolic process (GO:0009310)2.42014804
197cellular biogenic amine catabolic process (GO:0042402)2.42014804
198spinal cord motor neuron differentiation (GO:0021522)2.41288442
199benzene-containing compound metabolic process (GO:0042537)2.38665143

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.84603284
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.65883981
3GBX2_23144817_ChIP-Seq_PC3_Human3.54517609
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.52088618
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.45744587
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45337859
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17111404
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.16730580
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06435188
10EZH2_22144423_ChIP-Seq_EOC_Human3.02385291
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00382584
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.90707963
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.88257634
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.82657269
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.81202333
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.79230733
17VDR_22108803_ChIP-Seq_LS180_Human2.72497768
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65129218
19ZNF274_21170338_ChIP-Seq_K562_Hela2.62385564
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61677023
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59858302
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59440073
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57810079
24VDR_23849224_ChIP-Seq_CD4+_Human2.54779530
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52398321
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.50554617
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46761019
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43304120
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43290096
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37542875
31CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36290209
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.35959191
33TAF15_26573619_Chip-Seq_HEK293_Human2.35223745
34AR_21909140_ChIP-Seq_LNCAP_Human2.33958358
35MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33170861
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28885972
37FOXM1_23109430_ChIP-Seq_U2OS_Human2.28467170
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.22490379
39IGF1R_20145208_ChIP-Seq_DFB_Human2.18795559
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16619022
41FOXP3_21729870_ChIP-Seq_TREG_Human2.15319037
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03758252
43P300_19829295_ChIP-Seq_ESCs_Human2.03702147
44STAT3_23295773_ChIP-Seq_U87_Human2.01574623
45ELK1_19687146_ChIP-ChIP_HELA_Human2.01072991
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.99569818
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98729136
48XRN2_22483619_ChIP-Seq_HELA_Human1.97892232
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.97715244
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95298597
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.94988716
52EWS_26573619_Chip-Seq_HEK293_Human1.94909901
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93981304
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92455154
55AR_21572438_ChIP-Seq_LNCaP_Human1.91421796
56SMAD4_21799915_ChIP-Seq_A2780_Human1.89717554
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89048243
58GABP_19822575_ChIP-Seq_HepG2_Human1.88597652
59ER_23166858_ChIP-Seq_MCF-7_Human1.87031977
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84405780
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84319427
62TP53_16413492_ChIP-PET_HCT116_Human1.82046693
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81108147
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80512314
65DCP1A_22483619_ChIP-Seq_HELA_Human1.76906800
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76093729
67TCF4_23295773_ChIP-Seq_U87_Human1.75052522
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74286780
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.72853886
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72853886
71TTF2_22483619_ChIP-Seq_HELA_Human1.70562240
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.69193408
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.68379328
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67898395
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65971016
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.65786148
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64410557
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62699509
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61758958
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.61555113
81BCAT_22108803_ChIP-Seq_LS180_Human1.59402900
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.58627946
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58346431
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58254899
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56586955
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56198414
87KDM5A_27292631_Chip-Seq_BREAST_Human1.55946495
88AR_25329375_ChIP-Seq_VCAP_Human1.52527561
89CBP_20019798_ChIP-Seq_JUKART_Human1.51958368
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51958368
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50446930
92ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49162890
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48888737
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.46750152
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46537155
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.46022288
97AHR_22903824_ChIP-Seq_MCF-7_Human1.44936350
98DROSHA_22980978_ChIP-Seq_HELA_Human1.44079277
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43416330
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43381164
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42513142
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.41347984
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40471240
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39658364
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39160035
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37925314
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36444955
108TCF4_22108803_ChIP-Seq_LS180_Human1.34924840
109RUNX2_22187159_ChIP-Seq_PCA_Human1.34474862
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34229564
111CIITA_25753668_ChIP-Seq_RAJI_Human1.33938278
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.32509778
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31391611
114TFEB_21752829_ChIP-Seq_HELA_Human1.31207661
115FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30528269
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29918397
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.29006345
118* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28851927
119EGR1_19374776_ChIP-ChIP_THP-1_Human1.28769297
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.25400177
121TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25078922
122REST_21632747_ChIP-Seq_MESCs_Mouse1.24832893
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.24184942
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.23705740
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22025082
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20921050
127* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20781869
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20445457
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19721223
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.19528073
131KDM2B_26808549_Chip-Seq_REH_Human1.19411556
132RXR_22108803_ChIP-Seq_LS180_Human1.18434490
133ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16630505
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16437493
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.16263068
136CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16220900
137ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16032869
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15486189
139NFE2_27457419_Chip-Seq_LIVER_Mouse1.15301804
140NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15016810
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14906013
142FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13207416
143* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11947570
144* CBX2_27304074_Chip-Seq_ESCs_Mouse1.11484514
145CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10875646
146TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10685985
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10161106
148EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08978361
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08826010
150RNF2_27304074_Chip-Seq_NSC_Mouse1.08039484
151MYC_18940864_ChIP-ChIP_HL60_Human1.07333340
152SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06958330
153NOTCH1_21737748_ChIP-Seq_TLL_Human1.06495319
154AR_19668381_ChIP-Seq_PC3_Human1.06467437
155E2F1_18555785_Chip-Seq_ESCs_Mouse1.06457498
156P53_22387025_ChIP-Seq_ESCs_Mouse1.05892446
157SMAD3_21741376_ChIP-Seq_HESCs_Human1.04259959
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04236197
159CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03678716
160GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03110485
161CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02816931
162NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02086308
163NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02086308
164SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02083335
165STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01259538
166CRX_20693478_ChIP-Seq_RETINA_Mouse1.01096567
167CDX2_22108803_ChIP-Seq_LS180_Human1.00648028
168SMAD3_21741376_ChIP-Seq_ESCs_Human1.00461700
169NANOG_19829295_ChIP-Seq_ESCs_Human1.00210214
170SOX2_19829295_ChIP-Seq_ESCs_Human1.00210214
171OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99224725
172FUS_26573619_Chip-Seq_HEK293_Human0.99159857
173SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98977682
174FLI1_27457419_Chip-Seq_LIVER_Mouse0.98280474
175TP53_18474530_ChIP-ChIP_U2OS_Human0.97613894
176CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96065439
177BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95728637
178PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95050831
179KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94077066
180STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92688851
181POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91718208
182POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90259932
183IRF8_21731497_ChIP-ChIP_J774_Mouse0.88915403
184* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87023149
185SPI1_23547873_ChIP-Seq_NB4_Human0.85451381
186ELK1_22589737_ChIP-Seq_MCF10A_Human0.82350040
187TP63_19390658_ChIP-ChIP_HaCaT_Human0.81344197
188FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81131885
189NANOG_21062744_ChIP-ChIP_HESCs_Human0.77511799
190STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76255009
191SOX17_20123909_ChIP-Seq_XEN_Mouse0.75492789
192MYB_26560356_Chip-Seq_TH2_Human0.72915262
193CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72204304
194MYC_22102868_ChIP-Seq_BL_Human0.71497012
195KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70677652
196MYB_21317192_ChIP-Seq_ERMYB_Mouse0.68942454

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.47832969
2MP0010094_abnormal_chromosome_stability4.77772279
3MP0008877_abnormal_DNA_methylation4.08267918
4MP0003693_abnormal_embryo_hatching4.04223582
5MP0003111_abnormal_nucleus_morphology3.71747978
6MP0004957_abnormal_blastocyst_morpholog3.70304465
7MP0003077_abnormal_cell_cycle3.66741202
8MP0008058_abnormal_DNA_repair3.52808950
9MP0003195_calcinosis3.33080120
10MP0003718_maternal_effect3.31558914
11MP0003806_abnormal_nucleotide_metabolis3.22017727
12MP0003646_muscle_fatigue3.20131443
13MP0002396_abnormal_hematopoietic_system3.16721124
14MP0008007_abnormal_cellular_replicative3.04223345
15MP0008057_abnormal_DNA_replication2.96019003
16MP0009046_muscle_twitch2.71365474
17MP0004043_abnormal_pH_regulation2.47271405
18MP0003890_abnormal_embryonic-extraembry2.36704445
19MP0008932_abnormal_embryonic_tissue2.36384383
20MP0001968_abnormal_touch/_nociception2.25057424
21MP0010307_abnormal_tumor_latency2.24158432
22MP0000427_abnormal_hair_cycle2.22463042
23MP0005551_abnormal_eye_electrophysiolog2.22097002
24MP0001501_abnormal_sleep_pattern2.10426253
25MP0001929_abnormal_gametogenesis2.05869567
26MP0003186_abnormal_redox_activity1.98846740
27MP0000383_abnormal_hair_follicle1.98382894
28MP0001730_embryonic_growth_arrest1.97841403
29MP0002736_abnormal_nociception_after1.95592527
30MP0010352_gastrointestinal_tract_polyps1.90677855
31MP0003136_yellow_coat_color1.90196666
32MP0003123_paternal_imprinting1.89477095
33MP0009745_abnormal_behavioral_response1.86839362
34MP0000350_abnormal_cell_proliferation1.86426030
35MP0002210_abnormal_sex_determination1.82840614
36MP0003763_abnormal_thymus_physiology1.78162636
37MP0002653_abnormal_ependyma_morphology1.70797729
38MP0001486_abnormal_startle_reflex1.70365245
39MP0008961_abnormal_basal_metabolism1.67153227
40MP0000653_abnormal_sex_gland1.66875861
41MP0005174_abnormal_tail_pigmentation1.66104204
42MP0002735_abnormal_chemical_nociception1.65267314
43MP0004142_abnormal_muscle_tone1.63862933
44MP0003045_fibrosis1.63031492
45MP0001529_abnormal_vocalization1.60716919
46MP0005410_abnormal_fertilization1.57764030
47MP0005408_hypopigmentation1.56114892
48MP0003950_abnormal_plasma_membrane1.54840563
49MP0002272_abnormal_nervous_system1.52771601
50MP0003121_genomic_imprinting1.52294397
51MP0002837_dystrophic_cardiac_calcinosis1.51450947
52MP0000703_abnormal_thymus_morphology1.51224980
53MP0004924_abnormal_behavior1.51144628
54MP0005386_behavior/neurological_phenoty1.51144628
55MP0002064_seizures1.49696410
56MP0004130_abnormal_muscle_cell1.48667998
57MP0004233_abnormal_muscle_weight1.48352073
58MP0002019_abnormal_tumor_incidence1.48342250
59MP0004145_abnormal_muscle_electrophysio1.47447482
60MP0002398_abnormal_bone_marrow1.46924040
61MP0005671_abnormal_response_to1.46678653
62MP0009697_abnormal_copulation1.46470758
63MP0001119_abnormal_female_reproductive1.45345393
64MP0005646_abnormal_pituitary_gland1.45229808
65MP0002067_abnormal_sensory_capabilities1.43969960
66MP0006276_abnormal_autonomic_nervous1.43873100
67MP0001145_abnormal_male_reproductive1.43569047
68MP0001800_abnormal_humoral_immune1.42269287
69MP0003635_abnormal_synaptic_transmissio1.42011676
70MP0003880_abnormal_central_pattern1.40683800
71MP0001697_abnormal_embryo_size1.39025197
72MP0005395_other_phenotype1.38748848
73MP0000689_abnormal_spleen_morphology1.36685082
74MP0005253_abnormal_eye_physiology1.36311932
75MP0002572_abnormal_emotion/affect_behav1.35785674
76MP0002722_abnormal_immune_system1.33611868
77MP0000778_abnormal_nervous_system1.33158465
78MP0009333_abnormal_splenocyte_physiolog1.32774436
79MP0001986_abnormal_taste_sensitivity1.32592717
80MP0001485_abnormal_pinna_reflex1.31949524
81MP0003699_abnormal_female_reproductive1.29270103
82MP0002168_other_aberrant_phenotype1.27255319
83MP0000631_abnormal_neuroendocrine_gland1.26895686
84MP0010386_abnormal_urinary_bladder1.24435132
85MP0005380_embryogenesis_phenotype1.22828463
86MP0001672_abnormal_embryogenesis/_devel1.22828463
87MP0002557_abnormal_social/conspecific_i1.22268221
88MP0002063_abnormal_learning/memory/cond1.21710908
89MP0003786_premature_aging1.21659007
90MP0002080_prenatal_lethality1.21394121
91MP0005645_abnormal_hypothalamus_physiol1.19815703
92MP0006072_abnormal_retinal_apoptosis1.19309373
93MP0000313_abnormal_cell_death1.17465628
94MP0005187_abnormal_penis_morphology1.17248593
95MP0001970_abnormal_pain_threshold1.16132382
96MP0008872_abnormal_physiological_respon1.15327608
97MP0003787_abnormal_imprinting1.14839673
98MP0002161_abnormal_fertility/fecundity1.13693186
99MP0002102_abnormal_ear_morphology1.13483591
100MP0003937_abnormal_limbs/digits/tail_de1.13408411
101MP0002938_white_spotting1.12993742
102MP0004808_abnormal_hematopoietic_stem1.12915448
103MP0003698_abnormal_male_reproductive1.11196555
104MP0002928_abnormal_bile_duct1.10595827
105MP0006292_abnormal_olfactory_placode1.09850855
106MP0002638_abnormal_pupillary_reflex1.09829135
107MP0002429_abnormal_blood_cell1.09813595
108MP0000716_abnormal_immune_system1.09808771
109MP0000490_abnormal_crypts_of1.09556348
110MP0002733_abnormal_thermal_nociception1.08357225
111MP0001661_extended_life_span1.06690693
112MP0002734_abnormal_mechanical_nocicepti1.06301279
113MP0003984_embryonic_growth_retardation1.05171067
114MP0001915_intracranial_hemorrhage1.04781015
115MP0000538_abnormal_urinary_bladder1.04645107
116MP0001905_abnormal_dopamine_level1.03833862
117MP0004133_heterotaxia1.02634919
118MP0005310_abnormal_salivary_gland1.01878134
119MP0003633_abnormal_nervous_system1.01343525
120MP0001835_abnormal_antigen_presentation0.99808381
121MP0006054_spinal_hemorrhage0.99111393
122MP0002452_abnormal_antigen_presenting0.99019683
123MP0005171_absent_coat_pigmentation0.98534043
124MP0002088_abnormal_embryonic_growth/wei0.97955890
125MP0001919_abnormal_reproductive_system0.97734268
126MP0002420_abnormal_adaptive_immunity0.97623967
127MP0001873_stomach_inflammation0.97604375
128MP0002095_abnormal_skin_pigmentation0.96381362
129MP0002085_abnormal_embryonic_tissue0.94585217
130MP0001819_abnormal_immune_cell0.92745828
131MP0000955_abnormal_spinal_cord0.92303442
132MP0000685_abnormal_immune_system0.92264286
133MP0010678_abnormal_skin_adnexa0.92206549
134MP0005266_abnormal_metabolism0.91576350
135MP0002876_abnormal_thyroid_physiology0.91435336
136MP0000358_abnormal_cell_content/0.90438882
137MP0002882_abnormal_neuron_morphology0.90210101
138MP0003119_abnormal_digestive_system0.90092500
139MP0002723_abnormal_immune_serum0.89132907
140MP0005075_abnormal_melanosome_morpholog0.88400870
141MP0005670_abnormal_white_adipose0.88286905
142MP0004215_abnormal_myocardial_fiber0.87944502
143MP0001984_abnormal_olfaction0.87890738
144MP0003252_abnormal_bile_duct0.87802473
145MP0002184_abnormal_innervation0.87332390
146MP0003631_nervous_system_phenotype0.87179050
147MP0009765_abnormal_xenobiotic_induced0.86980584
148MP0002086_abnormal_extraembryonic_tissu0.86909104
149MP0002163_abnormal_gland_morphology0.86855072
150MP0005195_abnormal_posterior_eye0.86462335
151MP0004742_abnormal_vestibular_system0.86406958
152MP0004185_abnormal_adipocyte_glucose0.86399040
153MP0005389_reproductive_system_phenotype0.86268065
154MP0008260_abnormal_autophagy0.85447622
155MP0002752_abnormal_somatic_nervous0.83981360
156MP0000371_diluted_coat_color0.83744079
157MP0002229_neurodegeneration0.83014808
158MP0005621_abnormal_cell_physiology0.82771997
159MP0002084_abnormal_developmental_patter0.82422591
160MP0002009_preneoplasia0.81404788
161MP0005384_cellular_phenotype0.81273613
162MP0003137_abnormal_impulse_conducting0.81251704
163MP0008873_increased_physiological_sensi0.80463770
164MP0006035_abnormal_mitochondrial_morpho0.80399348
165MP0004885_abnormal_endolymph0.80300825
166MP0003632_abnormal_nervous_system0.78939434
167MP0004147_increased_porphyrin_level0.78099170
168MP0006036_abnormal_mitochondrial_physio0.77273653
169MP0001324_abnormal_eye_pigmentation0.76733388
170MP0000647_abnormal_sebaceous_gland0.76615816
171MP0000230_abnormal_systemic_arterial0.75941158
172MP0002132_abnormal_respiratory_system0.75446838
173MP0009115_abnormal_fat_cell0.74938587
174MP0008789_abnormal_olfactory_epithelium0.74589586
175MP0000858_altered_metastatic_potential0.73578410
176MP0000470_abnormal_stomach_morphology0.70174805
177MP0001293_anophthalmia0.69872086
178MP0000372_irregular_coat_pigmentation0.69535935
179MP0002405_respiratory_system_inflammati0.69497983
180MP0005448_abnormal_energy_balance0.69397813
181MP0002109_abnormal_limb_morphology0.68724591
182MP0003943_abnormal_hepatobiliary_system0.68465083
183MP0005499_abnormal_olfactory_system0.67551738
184MP0005394_taste/olfaction_phenotype0.67551738
185MP0004197_abnormal_fetal_growth/weight/0.65962222

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.32054659
2Genetic anticipation (HP:0003743)5.48577341
3Hyperventilation (HP:0002883)5.04054197
4Pancreatic cysts (HP:0001737)4.31869040
5Progressive cerebellar ataxia (HP:0002073)4.28467362
6Gaze-evoked nystagmus (HP:0000640)4.15201891
7Protruding tongue (HP:0010808)4.08389878
8Microvesicular hepatic steatosis (HP:0001414)3.69906464
9True hermaphroditism (HP:0010459)3.64141752
10Aplastic anemia (HP:0001915)3.60842255
11Type 2 muscle fiber atrophy (HP:0003554)3.45918168
12Molar tooth sign on MRI (HP:0002419)3.33696169
13Abnormality of midbrain morphology (HP:0002418)3.33696169
14Cerebral hypomyelination (HP:0006808)3.32856703
15Breast hypoplasia (HP:0003187)3.29999497
16Aplasia/Hypoplasia of the tibia (HP:0005772)3.28413832
17Clumsiness (HP:0002312)3.25853717
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.17404562
19Nephronophthisis (HP:0000090)3.13058840
20Chronic hepatic failure (HP:0100626)3.12513578
21Supernumerary spleens (HP:0009799)3.09906471
22Abnormality of the renal cortex (HP:0011035)3.08327025
23Febrile seizures (HP:0002373)3.06741131
24Fair hair (HP:0002286)3.03255826
25Abnormality of the renal medulla (HP:0100957)3.02618957
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02221147
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02221147
28Stenosis of the external auditory canal (HP:0000402)2.96195444
29Cystic liver disease (HP:0006706)2.91830743
30Chromsome breakage (HP:0040012)2.90402436
31Broad-based gait (HP:0002136)2.90032735
32Premature ovarian failure (HP:0008209)2.88415859
33Abnormality of the anterior horn cell (HP:0006802)2.88116106
34Degeneration of anterior horn cells (HP:0002398)2.88116106
35Muscle fiber atrophy (HP:0100295)2.81047619
36Medial flaring of the eyebrow (HP:0010747)2.76657414
37Carpal bone hypoplasia (HP:0001498)2.72041633
38Congenital stationary night blindness (HP:0007642)2.71332754
39Thrombocytosis (HP:0001894)2.64388360
40Absent speech (HP:0001344)2.64229487
41Abnormality of the labia minora (HP:0012880)2.59996638
42Abnormality of cells of the erythroid lineage (HP:0012130)2.58951819
43Rhabdomyosarcoma (HP:0002859)2.57074587
44Hypoplastic ischia (HP:0003175)2.55631315
45Rough bone trabeculation (HP:0100670)2.55288645
46Pulmonary fibrosis (HP:0002206)2.54569694
47Attenuation of retinal blood vessels (HP:0007843)2.53813261
48Tubular atrophy (HP:0000092)2.53236650
49Abnormality of the ischium (HP:0003174)2.52643947
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.51325040
51Neoplasm of the tracheobronchial system (HP:0100552)2.51311033
52Gait imbalance (HP:0002141)2.49556899
53Dysmetric saccades (HP:0000641)2.49074264
54CNS hypomyelination (HP:0003429)2.45676750
55Acute myeloid leukemia (HP:0004808)2.45367753
56Widely spaced teeth (HP:0000687)2.43867913
57Hypoplastic labia majora (HP:0000059)2.43779654
58Abnormality of lateral ventricle (HP:0030047)2.40596659
59Congenital primary aphakia (HP:0007707)2.38020479
60Papillary thyroid carcinoma (HP:0002895)2.37451335
61Generalized hypopigmentation of hair (HP:0011358)2.37003615
62Inability to walk (HP:0002540)2.36213116
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35577769
64Secondary amenorrhea (HP:0000869)2.35433169
65Dialeptic seizures (HP:0011146)2.34847739
66Alveolar cell carcinoma (HP:0006519)2.34781778
67Myelodysplasia (HP:0002863)2.34508872
68Preaxial foot polydactyly (HP:0001841)2.34073595
69Focal seizures (HP:0007359)2.33319517
70Cortical dysplasia (HP:0002539)2.33154604
71Abnormality of cochlea (HP:0000375)2.31818556
72Aplasia/Hypoplasia of the tongue (HP:0010295)2.31364599
73Drooling (HP:0002307)2.30785055
74Abnormality of glycolysis (HP:0004366)2.30096789
75Increased serum pyruvate (HP:0003542)2.30096789
76Abnormality of the labia majora (HP:0012881)2.29830703
77Hepatocellular necrosis (HP:0001404)2.29253025
78Abnormality of chromosome stability (HP:0003220)2.28823663
79Poor coordination (HP:0002370)2.26784442
80Genital tract atresia (HP:0001827)2.24914945
81Progressive inability to walk (HP:0002505)2.21708068
82Hypergonadotropic hypogonadism (HP:0000815)2.18895600
83Sloping forehead (HP:0000340)2.18324976
84Abnormality of B cell number (HP:0010975)2.18301690
85B lymphocytopenia (HP:0010976)2.18301690
86Vaginal atresia (HP:0000148)2.17688148
87Congenital hepatic fibrosis (HP:0002612)2.17631423
88Medulloblastoma (HP:0002885)2.14150656
89Male infertility (HP:0003251)2.14076077
90Impulsivity (HP:0100710)2.13823155
91Furrowed tongue (HP:0000221)2.12727553
92Abnormality of alanine metabolism (HP:0010916)2.12497678
93Hyperalaninemia (HP:0003348)2.12497678
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12497678
95Severe visual impairment (HP:0001141)2.12183920
96Urinary bladder sphincter dysfunction (HP:0002839)2.11174343
97Nephrogenic diabetes insipidus (HP:0009806)2.10943412
98Absence seizures (HP:0002121)2.10860518
99Tongue fasciculations (HP:0001308)2.10854183
100Short foot (HP:0001773)2.09433846
101Oral leukoplakia (HP:0002745)2.09080380
102Excessive salivation (HP:0003781)2.07690296
103Bony spicule pigmentary retinopathy (HP:0007737)2.07324822
104Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07102858
105Agnosia (HP:0010524)2.06612437
106Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06377766
107Asplenia (HP:0001746)2.06362391
108Overlapping toe (HP:0001845)2.04721949
109Cerebellar dysplasia (HP:0007033)2.04255867
110Patellar aplasia (HP:0006443)2.03939323
111Increased serum lactate (HP:0002151)2.03766720
112Premature graying of hair (HP:0002216)2.03723027
113Lip pit (HP:0100267)2.02651210
114Abnormal trabecular bone morphology (HP:0100671)2.00731854
115Oligodactyly (hands) (HP:0001180)1.98644836
116Combined immunodeficiency (HP:0005387)1.98192976
117Large for gestational age (HP:0001520)1.96273824
118Anencephaly (HP:0002323)1.96028210
119Congenital sensorineural hearing impairment (HP:0008527)1.95938729
120Autoamputation (HP:0001218)1.95907439
121Stomach cancer (HP:0012126)1.95316181
122Tented upper lip vermilion (HP:0010804)1.95183729
123Multiple enchondromatosis (HP:0005701)1.95113793
124Preaxial hand polydactyly (HP:0001177)1.94053758
125Postnatal microcephaly (HP:0005484)1.93845165
126Recurrent bronchitis (HP:0002837)1.93421209
127Cupped ear (HP:0000378)1.93155381
128Absent thumb (HP:0009777)1.93071212
129Sclerocornea (HP:0000647)1.92871256
130Postaxial foot polydactyly (HP:0001830)1.91932293
131Highly arched eyebrow (HP:0002553)1.90700128
132Atonic seizures (HP:0010819)1.90342494
133Type II lissencephaly (HP:0007260)1.90110727
134Abnormality of T cells (HP:0002843)1.88776199
135Bone marrow hypocellularity (HP:0005528)1.88305493
136Short chin (HP:0000331)1.87963836
137Absent radius (HP:0003974)1.87901110
138Bronchitis (HP:0012387)1.87794700
139Central scotoma (HP:0000603)1.87074833
140Renal cortical cysts (HP:0000803)1.86852721
141Decreased circulating renin level (HP:0003351)1.86616940
142Focal motor seizures (HP:0011153)1.86412707
143Abnormal number of erythroid precursors (HP:0012131)1.85800990
144Small hand (HP:0200055)1.85139367
145Lissencephaly (HP:0001339)1.84968666
146Easy fatigability (HP:0003388)1.84632920
147Facial hemangioma (HP:0000329)1.84152840
148Abolished electroretinogram (ERG) (HP:0000550)1.84064929
149Poor head control (HP:0002421)1.83349060
150Astigmatism (HP:0000483)1.81394532
151Aplasia involving forearm bones (HP:0009822)1.81382594
152Absent forearm bone (HP:0003953)1.81382594
153Spastic paraparesis (HP:0002313)1.81379922
154Aplasia/Hypoplasia of the patella (HP:0006498)1.80785440
155Irregular epiphyses (HP:0010582)1.80569274
156Truncal obesity (HP:0001956)1.80287538
157Absent/shortened dynein arms (HP:0200106)1.80164164
158Dynein arm defect of respiratory motile cilia (HP:0012255)1.80164164
159IgG deficiency (HP:0004315)1.79829329
160Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79755986
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79428624
162Absent epiphyses (HP:0010577)1.79428624
163Chronic bronchitis (HP:0004469)1.79354937
164Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79346217
165Polydipsia (HP:0001959)1.79204435
166Abnormal drinking behavior (HP:0030082)1.79204435
167Impaired smooth pursuit (HP:0007772)1.77002513
168T lymphocytopenia (HP:0005403)1.76967402
169Macrocytic anemia (HP:0001972)1.76397420
170Increased corneal curvature (HP:0100692)1.76239600
171Keratoconus (HP:0000563)1.76239600
172Abnormality of the preputium (HP:0100587)1.75698931
173Respiratory difficulties (HP:0002880)1.75241625
174Lymphoma (HP:0002665)1.75134708
175Clubbing of toes (HP:0100760)1.75022358
176Macroglossia (HP:0000158)1.74381061
177Intestinal atresia (HP:0011100)1.74309540
178Small intestinal stenosis (HP:0012848)1.74276835
179Duodenal stenosis (HP:0100867)1.74276835
180Abnormality of the renal collecting system (HP:0004742)1.73449744
181Tubulointerstitial nephritis (HP:0001970)1.73256512
182Entropion (HP:0000621)1.72233713
183Nephroblastoma (Wilms tumor) (HP:0002667)1.71494382
184Muscle fibrillation (HP:0010546)1.70990524
185Aplasia/Hypoplasia of the uvula (HP:0010293)1.70941220
186Hepatic necrosis (HP:0002605)1.70451989
187Increased CSF lactate (HP:0002490)1.70064589
188Abnormal lung lobation (HP:0002101)1.69535761
189Nasal polyposis (HP:0100582)1.68967242
190Meckel diverticulum (HP:0002245)1.68869770
191Pancreatic fibrosis (HP:0100732)1.68087651
192Lactic acidosis (HP:0003128)1.67495558
193Pancytopenia (HP:0001876)1.67489672
194Volvulus (HP:0002580)1.67377738
195Adrenal hypoplasia (HP:0000835)1.66663442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.92904775
2BUB14.02479936
3BMPR23.94770537
4CDC73.77844046
5ARAF3.31173161
6MAP3K133.30940574
7EIF2AK12.68411335
8PLK42.50753543
9CDK82.41048014
10RPS6KB22.17096706
11MKNK22.14285088
12WEE12.12084459
13BRAF2.10233713
14ACVR1B2.04559275
15EIF2AK32.03911392
16AKT31.98864093
17TSSK61.95974769
18TTK1.88497367
19ADRBK21.86655257
20WNK31.81004967
21RAF11.80357895
22PIM21.74856213
23MAPK131.73077275
24BRD41.71987300
25EEF2K1.71825169
26TNIK1.60214229
27PLK31.59777168
28SRPK11.56343104
29NTRK31.54144020
30NEK21.49733316
31MAP3K41.47553209
32PDK41.46382596
33PDK31.46382596
34INSRR1.45911960
35CHEK21.42415774
36STK101.42240880
37MAP3K61.41144694
38BCKDK1.41114418
39CAMK1G1.39173655
40GRK11.35303757
41PLK11.33016483
42MELK1.29826552
43CAMK1D1.26195986
44MOS1.24794349
45MAP3K91.24188112
46MAP4K11.22840227
47ATR1.22822734
48MARK11.21152553
49OXSR11.21028880
50MAP3K121.20889999
51ADRBK11.19445372
52VRK11.18348333
53LATS11.17017328
54FLT31.16400510
55PNCK1.12929487
56SGK21.11819530
57MAP4K21.11144146
58CHEK11.08502594
59LATS21.05950126
60TXK1.03639819
61PIK3CG1.01753888
62MAP3K81.01304388
63STK390.99639117
64PAK30.98658744
65PLK20.97663002
66PINK10.97215871
67PIK3CA0.96462105
68ERBB40.94742534
69PASK0.93852586
70CSNK1G30.91315818
71MAP3K50.91083203
72STK30.91026172
73NEK10.90411259
74NLK0.88480496
75AURKB0.88389798
76PIM10.88320869
77WNK40.87067454
78TEC0.85811029
79BRSK20.85497662
80TGFBR10.83871457
81AURKA0.83549871
82CDK70.83420965
83DAPK20.82204906
84CAMKK20.81911546
85ITK0.81698078
86MAP3K70.81088983
87MKNK10.80973630
88ATM0.80159295
89CDK120.79887010
90PBK0.76960485
91SCYL20.76680661
92BMPR1B0.76605579
93TESK20.76543337
94STK38L0.76378627
95TAOK30.76363797
96PRKAA20.76079148
97NUAK10.75451211
98TAOK10.75025059
99CSNK1G10.74837053
100CDK90.73583019
101MAPKAPK30.73252228
102PTK2B0.71268483
103SGK4940.69932268
104SGK2230.69932268
105NEK90.69902531
106STK380.69696014
107PAK40.69473671
108EPHA40.68907882
109PRKCE0.68789682
110SIK20.68616325
111FGFR20.68306546
112CDK40.68020585
113KIT0.67440968
114PRKCG0.66281337
115WNK10.65620166
116OBSCN0.63923255
117CHUK0.63238167
118RPS6KA40.62678313
119STK160.60974718
120IKBKB0.60624506
121CSNK1A1L0.60042287
122CAMK40.59666162
123TLK10.59648144
124CAMK10.59607891
125ERBB20.59406834
126MAP2K30.59280069
127STK110.58776006
128NTRK20.58232639
129NME20.56451006
130PKN10.55040150
131CSNK2A20.53005047
132CSNK1G20.52224515
133SGK10.51583426
134BRSK10.50951791
135PRKAA10.49977797
136TRPM70.49068085
137MAP2K70.48014900
138ZAK0.47367841
139SGK30.46929880
140CDK20.46863486
141CAMK2A0.46821212
142PAK10.45913974
143KSR20.44171159
144CSNK1D0.44104221
145IRAK10.43930884
146EPHA30.43787041
147CASK0.43475665
148FER0.43293967
149TNK20.43078585
150JAK30.43011069
151PDK20.42683068
152RPS6KB10.42537700
153ILK0.41391704
154ZAP700.40770700
155MAPKAPK50.40264516
156STK240.39224597
157CSNK2A10.37934395
158CDK30.36434913
159CDK10.34718339
160MAPK110.33352636
161DYRK1A0.33233087
162PRKCH0.33063734
163RPS6KA30.32498464
164GSK3B0.31347426
165PRKACB0.30888065
166MARK20.30571339
167MARK30.29588882
168MAP2K60.29459931
169MAPK80.29072065
170PRKG10.28598755
171PRKACA0.27865342
172MAP2K10.27320010
173MAP2K40.27102759
174PDGFRB0.26212361
175PRKCZ0.23995809
176PRKCB0.23724359

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.05290253
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.91207960
3RNA polymerase_Homo sapiens_hsa030203.67828054
4DNA replication_Homo sapiens_hsa030303.32419276
5Non-homologous end-joining_Homo sapiens_hsa034503.31185418
6Mismatch repair_Homo sapiens_hsa034303.30091067
7Nicotine addiction_Homo sapiens_hsa050332.99174200
8RNA transport_Homo sapiens_hsa030132.91932661
9Basal transcription factors_Homo sapiens_hsa030222.85482155
10Cell cycle_Homo sapiens_hsa041102.79926158
11Ribosome_Homo sapiens_hsa030102.65080667
12Base excision repair_Homo sapiens_hsa034102.57454852
13RNA degradation_Homo sapiens_hsa030182.55766686
14Homologous recombination_Homo sapiens_hsa034402.48507907
15Nucleotide excision repair_Homo sapiens_hsa034202.44909261
16Spliceosome_Homo sapiens_hsa030402.35683321
17Pyrimidine metabolism_Homo sapiens_hsa002402.27465679
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26030732
19ABC transporters_Homo sapiens_hsa020102.25366208
20Phototransduction_Homo sapiens_hsa047442.23081600
21Butanoate metabolism_Homo sapiens_hsa006502.20358244
22One carbon pool by folate_Homo sapiens_hsa006702.17730582
23Taste transduction_Homo sapiens_hsa047422.09909848
24Nitrogen metabolism_Homo sapiens_hsa009102.09430164
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91632088
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.86909627
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85392425
28Tryptophan metabolism_Homo sapiens_hsa003801.84008278
29Lysine degradation_Homo sapiens_hsa003101.77973338
30Glutamatergic synapse_Homo sapiens_hsa047241.76932083
31Morphine addiction_Homo sapiens_hsa050321.76452991
32Fanconi anemia pathway_Homo sapiens_hsa034601.73391912
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69751071
34Dorso-ventral axis formation_Homo sapiens_hsa043201.67327664
35Vitamin B6 metabolism_Homo sapiens_hsa007501.65875852
36Circadian entrainment_Homo sapiens_hsa047131.63519636
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.61828287
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60778823
39Protein export_Homo sapiens_hsa030601.60254673
40Purine metabolism_Homo sapiens_hsa002301.56927027
41Antigen processing and presentation_Homo sapiens_hsa046121.56053245
42p53 signaling pathway_Homo sapiens_hsa041151.49817435
43Olfactory transduction_Homo sapiens_hsa047401.45462528
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.41538898
45Calcium signaling pathway_Homo sapiens_hsa040201.41159368
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.40788373
47Epstein-Barr virus infection_Homo sapiens_hsa051691.39237854
48mRNA surveillance pathway_Homo sapiens_hsa030151.38922069
49Serotonergic synapse_Homo sapiens_hsa047261.34561801
50GABAergic synapse_Homo sapiens_hsa047271.32436903
51Salivary secretion_Homo sapiens_hsa049701.30645864
52Insulin secretion_Homo sapiens_hsa049111.26982548
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25848005
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24459426
55Histidine metabolism_Homo sapiens_hsa003401.23818442
56Glycerolipid metabolism_Homo sapiens_hsa005611.20359631
57Long-term depression_Homo sapiens_hsa047301.18047401
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.15448637
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13434420
60Cholinergic synapse_Homo sapiens_hsa047251.10237263
61Biosynthesis of amino acids_Homo sapiens_hsa012301.07922578
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07203784
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07169364
64Pentose phosphate pathway_Homo sapiens_hsa000301.05494893
65Regulation of autophagy_Homo sapiens_hsa041401.02428167
66Dopaminergic synapse_Homo sapiens_hsa047281.01643654
67Sulfur relay system_Homo sapiens_hsa041221.01131495
68Graft-versus-host disease_Homo sapiens_hsa053321.00329587
69cAMP signaling pathway_Homo sapiens_hsa040241.00037236
70Gastric acid secretion_Homo sapiens_hsa049710.98782833
71Oxytocin signaling pathway_Homo sapiens_hsa049210.95967059
72Oocyte meiosis_Homo sapiens_hsa041140.93331805
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92817310
74Primary immunodeficiency_Homo sapiens_hsa053400.92568240
75Type II diabetes mellitus_Homo sapiens_hsa049300.88793514
76Retinol metabolism_Homo sapiens_hsa008300.88631325
77Chemical carcinogenesis_Homo sapiens_hsa052040.86790311
78Renin secretion_Homo sapiens_hsa049240.84863063
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84730475
80Herpes simplex infection_Homo sapiens_hsa051680.83906184
81Fatty acid biosynthesis_Homo sapiens_hsa000610.81720840
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80908773
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80838870
84Glutathione metabolism_Homo sapiens_hsa004800.77043248
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76903547
86Folate biosynthesis_Homo sapiens_hsa007900.76875967
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76289106
88beta-Alanine metabolism_Homo sapiens_hsa004100.75894334
89Systemic lupus erythematosus_Homo sapiens_hsa053220.75724288
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75702498
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75302665
92Viral carcinogenesis_Homo sapiens_hsa052030.75206083
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73715714
94Pancreatic cancer_Homo sapiens_hsa052120.73631173
95Cocaine addiction_Homo sapiens_hsa050300.72565660
96Amphetamine addiction_Homo sapiens_hsa050310.72405738
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.72314119
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71900851
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70275517
100Type I diabetes mellitus_Homo sapiens_hsa049400.69067739
101Allograft rejection_Homo sapiens_hsa053300.67426298
102Thyroid cancer_Homo sapiens_hsa052160.66996799
103Pyruvate metabolism_Homo sapiens_hsa006200.66140528
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65750004
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65719224
106T cell receptor signaling pathway_Homo sapiens_hsa046600.61633698
107Pancreatic secretion_Homo sapiens_hsa049720.61183333
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60404292
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60016359
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.58929661
111Sphingolipid metabolism_Homo sapiens_hsa006000.58912346
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.58583938
113Axon guidance_Homo sapiens_hsa043600.58235650
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58108599
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57610675
116Apoptosis_Homo sapiens_hsa042100.57237893
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56945650
118Choline metabolism in cancer_Homo sapiens_hsa052310.55205694
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54638236
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54275641
121Huntingtons disease_Homo sapiens_hsa050160.53665785
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53390309
123Measles_Homo sapiens_hsa051620.53190518
124TGF-beta signaling pathway_Homo sapiens_hsa043500.52820431
125Selenocompound metabolism_Homo sapiens_hsa004500.52774831
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52004338
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51008551
128MAPK signaling pathway_Homo sapiens_hsa040100.49979557
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48724539
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.48636084
131Ras signaling pathway_Homo sapiens_hsa040140.48279407
132Melanoma_Homo sapiens_hsa052180.47728764
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46771596
134Carbon metabolism_Homo sapiens_hsa012000.46741305
135Hippo signaling pathway_Homo sapiens_hsa043900.45566222
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.45564611
137Bile secretion_Homo sapiens_hsa049760.45440958
138Hedgehog signaling pathway_Homo sapiens_hsa043400.45342376
139Shigellosis_Homo sapiens_hsa051310.44522775
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44105913
141Arachidonic acid metabolism_Homo sapiens_hsa005900.43475669
142Fructose and mannose metabolism_Homo sapiens_hsa000510.43030560
143Platelet activation_Homo sapiens_hsa046110.42914981
144Caffeine metabolism_Homo sapiens_hsa002320.42795559
145Estrogen signaling pathway_Homo sapiens_hsa049150.42514100
146Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41921144
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39220758
148NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38905725
149HTLV-I infection_Homo sapiens_hsa051660.37961742
150Basal cell carcinoma_Homo sapiens_hsa052170.37151569
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37066085
152MicroRNAs in cancer_Homo sapiens_hsa052060.35995630
153Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34980656
154Ovarian steroidogenesis_Homo sapiens_hsa049130.33872133
155NF-kappa B signaling pathway_Homo sapiens_hsa040640.33630756
156Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32692566
157Colorectal cancer_Homo sapiens_hsa052100.32306037
158Legionellosis_Homo sapiens_hsa051340.31921737
159Ether lipid metabolism_Homo sapiens_hsa005650.31088843
160Metabolic pathways_Homo sapiens_hsa011000.30649650
161Linoleic acid metabolism_Homo sapiens_hsa005910.29455403
162Influenza A_Homo sapiens_hsa051640.28568336
163Circadian rhythm_Homo sapiens_hsa047100.26746993
164Peroxisome_Homo sapiens_hsa041460.26465242
165Hepatitis B_Homo sapiens_hsa051610.26372047
166Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25177102
167Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23970575
168Oxidative phosphorylation_Homo sapiens_hsa001900.23494256
169Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23424615
170Jak-STAT signaling pathway_Homo sapiens_hsa046300.20214970
171Non-small cell lung cancer_Homo sapiens_hsa052230.19893707
172HIF-1 signaling pathway_Homo sapiens_hsa040660.18976104
173Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17025208
174RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17001817
175Parkinsons disease_Homo sapiens_hsa050120.16942203
176Propanoate metabolism_Homo sapiens_hsa006400.14865773
177FoxO signaling pathway_Homo sapiens_hsa040680.12943728
178Steroid biosynthesis_Homo sapiens_hsa001000.11466347
179Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.11142163
180SNARE interactions in vesicular transport_Homo sapiens_hsa041300.10938455
181Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.09653116

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