RPE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)5.00182978
2nuclear pore complex assembly (GO:0051292)4.74012639
3proteasome assembly (GO:0043248)4.04803021
4ribosomal small subunit assembly (GO:0000028)3.96015636
5regulation of centriole replication (GO:0046599)3.92998451
6histone exchange (GO:0043486)3.82174692
7mitotic sister chromatid cohesion (GO:0007064)3.76673530
8metaphase plate congression (GO:0051310)3.76394452
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.72519541
10double-strand break repair via nonhomologous end joining (GO:0006303)3.70955530
11non-recombinational repair (GO:0000726)3.70955530
12DNA double-strand break processing (GO:0000729)3.69938314
13establishment of viral latency (GO:0019043)3.69568844
14mitotic sister chromatid segregation (GO:0000070)3.54954518
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.47352542
16sister chromatid segregation (GO:0000819)3.44659566
17DNA ligation (GO:0006266)3.44539274
18pore complex assembly (GO:0046931)3.41845042
19folic acid-containing compound biosynthetic process (GO:0009396)3.40748072
20spindle checkpoint (GO:0031577)3.40723901
21cullin deneddylation (GO:0010388)3.36146517
22viral transcription (GO:0019083)3.35457524
23response to X-ray (GO:0010165)3.34624476
24translational termination (GO:0006415)3.33854809
25negative regulation of DNA-dependent DNA replication (GO:2000104)3.30926097
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.29308143
27mitotic spindle checkpoint (GO:0071174)3.28986076
28DNA strand elongation involved in DNA replication (GO:0006271)3.28783210
29tRNA aminoacylation for protein translation (GO:0006418)3.25957519
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.24882374
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.24882374
32amino acid activation (GO:0043038)3.24070691
33tRNA aminoacylation (GO:0043039)3.24070691
34cotranslational protein targeting to membrane (GO:0006613)3.22409621
35negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22398437
36negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22398437
37negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22398437
38negative regulation of mitotic sister chromatid separation (GO:2000816)3.22398437
39negative regulation of sister chromatid segregation (GO:0033046)3.22398437
40protein targeting to ER (GO:0045047)3.20771672
41negative regulation of chromosome segregation (GO:0051985)3.19799934
42telomere maintenance via semi-conservative replication (GO:0032201)3.19725404
43establishment of chromosome localization (GO:0051303)3.18614291
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18312135
45regulation of mitotic spindle checkpoint (GO:1903504)3.18312135
46DNA deamination (GO:0045006)3.18261057
47negative regulation of ligase activity (GO:0051352)3.15589512
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15589512
49regulation of chromosome segregation (GO:0051983)3.15340063
50regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14716977
51regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14716977
52DNA strand elongation (GO:0022616)3.10887998
53postreplication repair (GO:0006301)3.09784337
54RNA-dependent DNA replication (GO:0006278)3.08086454
55protein localization to endoplasmic reticulum (GO:0070972)3.06293260
56protein deneddylation (GO:0000338)3.03576121
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.03414295
58DNA catabolic process, exonucleolytic (GO:0000738)3.02912881
59regulation of sister chromatid segregation (GO:0033045)3.01971978
60regulation of mitotic sister chromatid separation (GO:0010965)3.01971978
61regulation of mitotic sister chromatid segregation (GO:0033047)3.01971978
62mitotic spindle assembly checkpoint (GO:0007094)3.01096122
63ribosomal small subunit biogenesis (GO:0042274)3.00996640
64formation of translation preinitiation complex (GO:0001731)3.00815099
65DNA unwinding involved in DNA replication (GO:0006268)2.99513222
66spindle assembly checkpoint (GO:0071173)2.99332858
67replication fork processing (GO:0031297)2.97554911
68telomere maintenance via recombination (GO:0000722)2.96720619
69lactate metabolic process (GO:0006089)2.95709262
70L-serine metabolic process (GO:0006563)2.95637829
71nucleobase biosynthetic process (GO:0046112)2.94694699
72translational elongation (GO:0006414)2.94073109
73telomere maintenance via telomerase (GO:0007004)2.93466586
74regulation of centrosome cycle (GO:0046605)2.92734474
75positive regulation of chromosome segregation (GO:0051984)2.92042427
76maturation of SSU-rRNA (GO:0030490)2.91587879
77regulation of helicase activity (GO:0051095)2.90548959
78RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90393132
79somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89146925
80somatic hypermutation of immunoglobulin genes (GO:0016446)2.89146925
81protein K6-linked ubiquitination (GO:0085020)2.88852502
82maturation of 5.8S rRNA (GO:0000460)2.87372720
83DNA damage response, detection of DNA damage (GO:0042769)2.87255864
84purine nucleobase biosynthetic process (GO:0009113)2.87062145
85translational initiation (GO:0006413)2.85561061
86spliceosomal snRNP assembly (GO:0000387)2.83792925
87rRNA modification (GO:0000154)2.83513797
88DNA replication initiation (GO:0006270)2.82903981
89histone mRNA metabolic process (GO:0008334)2.81165526
90antigen processing and presentation of endogenous antigen (GO:0019883)2.80105848
91CENP-A containing nucleosome assembly (GO:0034080)2.80035138
92mitotic recombination (GO:0006312)2.77692860
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.73245877
94antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.73091608
95chromatin remodeling at centromere (GO:0031055)2.69941916
96folic acid metabolic process (GO:0046655)2.67823970
97protein localization to kinetochore (GO:0034501)2.66113581
98viral life cycle (GO:0019058)2.65910865
99DNA replication checkpoint (GO:0000076)2.63602231
100Arp2/3 complex-mediated actin nucleation (GO:0034314)2.62941650
101ribosomal large subunit biogenesis (GO:0042273)2.62016417
102nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.61298768
103DNA replication-dependent nucleosome assembly (GO:0006335)2.56355257
104DNA replication-dependent nucleosome organization (GO:0034723)2.56355257
105mitotic metaphase plate congression (GO:0007080)2.56009253
106mitotic nuclear envelope disassembly (GO:0007077)2.55609094
107attachment of spindle microtubules to kinetochore (GO:0008608)2.53686308
108pteridine-containing compound biosynthetic process (GO:0042559)2.53452448
109cellular protein complex disassembly (GO:0043624)2.52481587
110telomere maintenance via telomere lengthening (GO:0010833)2.52388584
111IMP biosynthetic process (GO:0006188)2.45343824
112ribonucleoprotein complex biogenesis (GO:0022613)2.45139536
113B cell mediated immunity (GO:0019724)2.45061129
114DNA replication-independent nucleosome assembly (GO:0006336)2.43993281
115DNA replication-independent nucleosome organization (GO:0034724)2.43993281
116kinetochore organization (GO:0051383)2.43373964
117tetrahydrofolate metabolic process (GO:0046653)2.41716517
118antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.41516363
119IMP metabolic process (GO:0046040)2.40033022
120ribosome assembly (GO:0042255)2.39790184
121negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.38902356
122nucleotide-excision repair, DNA gap filling (GO:0006297)2.38358299
123membrane disassembly (GO:0030397)2.38121227
124nuclear envelope disassembly (GO:0051081)2.38121227
125protein localization to chromosome, centromeric region (GO:0071459)2.37710475
126natural killer cell mediated cytotoxicity (GO:0042267)2.37697430
127natural killer cell mediated immunity (GO:0002228)2.37697430
128translation (GO:0006412)2.35172159
129regulation of spindle organization (GO:0090224)2.34115977
130* pentose-phosphate shunt (GO:0006098)2.31543927
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.30482591
132signal peptide processing (GO:0006465)2.29983765
133somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.29750683
134isotype switching (GO:0045190)2.29750683
135somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.29750683
136pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.28229818
137valine metabolic process (GO:0006573)2.27541152
138positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.26698458
139anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.25856950
140regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.23751608
141nuclear pore organization (GO:0006999)2.23137175
142glycine metabolic process (GO:0006544)2.21962812
143ribosome biogenesis (GO:0042254)2.21541065
144serine family amino acid biosynthetic process (GO:0009070)2.20347131
145rRNA processing (GO:0006364)2.19423306
146neutrophil activation involved in immune response (GO:0002283)2.19147303
147DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.19101282
148folic acid-containing compound metabolic process (GO:0006760)2.18800143
149signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.18716762
150intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.18716762
151regulation of protein heterodimerization activity (GO:0043497)2.18243591
152* NADPH regeneration (GO:0006740)2.18185786
153cell cycle G1/S phase transition (GO:0044843)2.16702690
154G1/S transition of mitotic cell cycle (GO:0000082)2.16702690
155signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.15781495
156signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.15781495
157signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.15781495
158telomere organization (GO:0032200)2.15618528
159telomere maintenance (GO:0000723)2.14501090
160regulation of cellular amino acid metabolic process (GO:0006521)2.14175935
161signal transduction involved in DNA damage checkpoint (GO:0072422)2.13505734
162signal transduction involved in DNA integrity checkpoint (GO:0072401)2.13505734
163nucleobase-containing small molecule interconversion (GO:0015949)2.12867516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.69357742
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.29816268
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16332501
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.97213427
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.86326657
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85482380
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72029889
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71232050
9* GABP_17652178_ChIP-ChIP_JURKAT_Human2.61925325
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43851990
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.41633106
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35406240
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32036962
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.29180403
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16920897
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15610786
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13274828
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.11450995
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07589040
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07008809
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04577767
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.04534642
23VDR_23849224_ChIP-Seq_CD4+_Human1.99737664
24* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99187937
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98212037
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97766527
27AR_21909140_ChIP-Seq_LNCAP_Human1.93644911
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90957037
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86211233
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83672742
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82502347
32GATA1_22025678_ChIP-Seq_K562_Human1.81428166
33XRN2_22483619_ChIP-Seq_HELA_Human1.79870749
34* ELK1_19687146_ChIP-ChIP_HELA_Human1.77376046
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74481567
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.74361971
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74355175
38DCP1A_22483619_ChIP-Seq_HELA_Human1.74338598
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72548806
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71309943
41FOXP3_21729870_ChIP-Seq_TREG_Human1.66609097
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65945953
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65663960
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65461934
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63627750
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62669091
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.62459098
48* EWS_26573619_Chip-Seq_HEK293_Human1.61245035
49* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60656703
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60305974
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57577484
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56359825
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.55458995
54* FUS_26573619_Chip-Seq_HEK293_Human1.55141630
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53678061
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53121738
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51391563
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.46085233
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45809110
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44843707
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44679171
62* SPI1_23547873_ChIP-Seq_NB4_Human1.43367495
63* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42581090
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42147928
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37148818
66* GABP_19822575_ChIP-Seq_HepG2_Human1.36190085
67* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35371944
68* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34898764
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34237244
70* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33955083
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.32371433
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30715179
73* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30697627
74* FLI1_27457419_Chip-Seq_LIVER_Mouse1.27843051
75TFEB_21752829_ChIP-Seq_HELA_Human1.27412623
76SOX17_20123909_ChIP-Seq_XEN_Mouse1.27045231
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26262018
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.26187495
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23486212
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22175412
81TTF2_22483619_ChIP-Seq_HELA_Human1.21865552
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21246574
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19690938
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19649367
85* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19161338
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19069675
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18903192
88MYC_18940864_ChIP-ChIP_HL60_Human1.17508604
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17027008
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15557252
91PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13847455
92MYB_26560356_Chip-Seq_TH2_Human1.13035219
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11699498
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11488593
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10983535
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10466951
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08597441
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07271680
99RXR_22158963_ChIP-Seq_LIVER_Mouse1.07100019
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06027765
101* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05953436
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05667937
103* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05567209
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05296722
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05286788
106KDM5A_27292631_Chip-Seq_BREAST_Human1.03021449
107* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02487943
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02205152
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00518349
110* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00412516
111MYC_22102868_ChIP-Seq_BL_Human1.00397540
112MYB_26560356_Chip-Seq_TH1_Human0.99899155
113VDR_21846776_ChIP-Seq_THP-1_Human0.98526612
114SOX2_16153702_ChIP-ChIP_HESCs_Human0.98315185
115* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97588930
116ELK1_22589737_ChIP-Seq_MCF10A_Human0.95946308
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95629637
118KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95223791
119* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95111844
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94179418
121IRF8_27001747_Chip-Seq_BMDM_Mouse0.94126343
122* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91882728
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91647223
124SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90553863
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90165806
126* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89774838
127VDR_22108803_ChIP-Seq_LS180_Human0.89760762
128WT1_19549856_ChIP-ChIP_CCG9911_Human0.89576403
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86438265
130ZNF274_21170338_ChIP-Seq_K562_Hela0.86057736
131IGF1R_20145208_ChIP-Seq_DFB_Human0.84636480
132NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84116326
133TAF15_26573619_Chip-Seq_HEK293_Human0.83050326
134P300_19829295_ChIP-Seq_ESCs_Human0.76641368
135* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76029547
136EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.75017795
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73378197
138* EZH2_27294783_Chip-Seq_NPCs_Mouse0.73281074
139* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72877834
140* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71380866
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.69950944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.72049433
2MP0003806_abnormal_nucleotide_metabolis3.39193039
3MP0003693_abnormal_embryo_hatching3.10195827
4MP0004957_abnormal_blastocyst_morpholog2.51603814
5MP0001835_abnormal_antigen_presentation2.30771892
6MP0009785_altered_susceptibility_to2.28357940
7MP0010094_abnormal_chromosome_stability2.26043722
8MP0003724_increased_susceptibility_to2.15128584
9MP0003436_decreased_susceptibility_to2.10497735
10MP0003186_abnormal_redox_activity2.05011377
11MP0003890_abnormal_embryonic-extraembry1.97994938
12MP0002139_abnormal_hepatobiliary_system1.94647539
13MP0003077_abnormal_cell_cycle1.93088294
14MP0002396_abnormal_hematopoietic_system1.92632673
15MP0008057_abnormal_DNA_replication1.90306201
16MP0000685_abnormal_immune_system1.87522723
17MP0010352_gastrointestinal_tract_polyps1.87388927
18MP0003111_abnormal_nucleus_morphology1.86575383
19MP0005360_urolithiasis1.85541394
20MP0008877_abnormal_DNA_methylation1.80225933
21MP0005671_abnormal_response_to1.76228156
22MP0002166_altered_tumor_susceptibility1.76140881
23MP0005025_abnormal_response_to1.66611619
24MP0002938_white_spotting1.63415262
25MP0001293_anophthalmia1.63094875
26MP0010307_abnormal_tumor_latency1.59594155
27MP0005000_abnormal_immune_tolerance1.56990787
28MP0002006_tumorigenesis1.56681602
29MP0001697_abnormal_embryo_size1.56190216
30MP0001853_heart_inflammation1.53487599
31MP0002148_abnormal_hypersensitivity_rea1.52272931
32MP0001672_abnormal_embryogenesis/_devel1.51947671
33MP0005380_embryogenesis_phenotype1.51947671
34MP0002419_abnormal_innate_immunity1.50561712
35MP0003937_abnormal_limbs/digits/tail_de1.50342054
36MP0003763_abnormal_thymus_physiology1.49148141
37MP0008007_abnormal_cellular_replicative1.46807098
38MP0001800_abnormal_humoral_immune1.46022285
39MP0000490_abnormal_crypts_of1.44962101
40MP0009840_abnormal_foam_cell1.43395845
41MP0009333_abnormal_splenocyte_physiolog1.42517222
42MP0002452_abnormal_antigen_presenting1.41072301
43MP0002084_abnormal_developmental_patter1.40960557
44MP0006082_CNS_inflammation1.39884741
45MP0009672_abnormal_birth_weight1.36578674
46MP0000358_abnormal_cell_content/1.35182620
47MP0002723_abnormal_immune_serum1.34623078
48MP0003984_embryonic_growth_retardation1.33919438
49MP0002088_abnormal_embryonic_growth/wei1.33207916
50MP0002420_abnormal_adaptive_immunity1.31254287
51MP0000858_altered_metastatic_potential1.30589001
52MP0001819_abnormal_immune_cell1.30114937
53MP0002085_abnormal_embryonic_tissue1.28698677
54MP0006054_spinal_hemorrhage1.28653416
55MP0001545_abnormal_hematopoietic_system1.28532073
56MP0005397_hematopoietic_system_phenotyp1.28532073
57MP0010234_abnormal_vibrissa_follicle1.28443287
58MP0002080_prenatal_lethality1.26893305
59MP0002398_abnormal_bone_marrow1.26472178
60MP0002090_abnormal_vision1.25290303
61MP0009379_abnormal_foot_pigmentation1.23874660
62MP0000372_irregular_coat_pigmentation1.22971754
63MP0004947_skin_inflammation1.22734015
64MP0005365_abnormal_bile_salt1.20981214
65MP0002019_abnormal_tumor_incidence1.20743604
66MP0000689_abnormal_spleen_morphology1.20585358
67MP0006292_abnormal_olfactory_placode1.20317622
68MP0008058_abnormal_DNA_repair1.20220015
69MP0001533_abnormal_skeleton_physiology1.19471453
70MP0003656_abnormal_erythrocyte_physiolo1.19219937
71MP0003567_abnormal_fetal_cardiomyocyte1.19212896
72MP0002722_abnormal_immune_system1.18268915
73MP0002233_abnormal_nose_morphology1.17948973
74MP0001845_abnormal_inflammatory_respons1.16824980
75MP0003121_genomic_imprinting1.16802314
76MP0000716_abnormal_immune_system1.16654783
77MP0008469_abnormal_protein_level1.16377787
78MP0001790_abnormal_immune_system1.16157877
79MP0005387_immune_system_phenotype1.16157877
80MP0008932_abnormal_embryonic_tissue1.15967474
81MP0002697_abnormal_eye_size1.15255256
82MP0000647_abnormal_sebaceous_gland1.14636833
83MP0006035_abnormal_mitochondrial_morpho1.14567230
84MP0005076_abnormal_cell_differentiation1.13501158
85MP0006072_abnormal_retinal_apoptosis1.13130267
86MP0010155_abnormal_intestine_physiology1.12838586
87MP0002405_respiratory_system_inflammati1.12802836
88MP0000350_abnormal_cell_proliferation1.11070869
89MP0002429_abnormal_blood_cell1.09905914
90MP0005464_abnormal_platelet_physiology1.06883279
91MP0009764_decreased_sensitivity_to1.06551583
92MP0002086_abnormal_extraembryonic_tissu1.05802070
93MP0005058_abnormal_lysosome_morphology1.05629868
94MP0001730_embryonic_growth_arrest1.04220636
95MP0005023_abnormal_wound_healing1.03729898
96MP0001177_atelectasis1.03037829
97MP0005085_abnormal_gallbladder_physiolo1.02886904
98MP0000609_abnormal_liver_physiology1.02616374
99MP0003718_maternal_effect1.02557748
100MP0009763_increased_sensitivity_to1.01291932
101MP0001286_abnormal_eye_development1.00482790
102MP0001666_abnormal_nutrient_absorption0.99541998
103MP0009703_decreased_birth_body0.98987710
104MP0003123_paternal_imprinting0.98887617
105MP0004197_abnormal_fetal_growth/weight/0.97796588
106MP0008438_abnormal_cutaneous_collagen0.97091274
107MP0003191_abnormal_cellular_cholesterol0.95992181
108MP0010678_abnormal_skin_adnexa0.95602883
109MP0003300_gastrointestinal_ulcer0.95535760
110MP0008875_abnormal_xenobiotic_pharmacok0.94231278
111MP0003172_abnormal_lysosome_physiology0.92388135
112MP0003448_altered_tumor_morphology0.91979750
113MP0002102_abnormal_ear_morphology0.90744307
114MP0005319_abnormal_enzyme/_coenzyme0.86991361
115MP0003453_abnormal_keratinocyte_physiol0.86861232
116MP0000598_abnormal_liver_morphology0.85917028
117MP0000428_abnormal_craniofacial_morphol0.85825336
118MP0003950_abnormal_plasma_membrane0.85776442
119MP0009697_abnormal_copulation0.85744062
120MP0009643_abnormal_urine_homeostasis0.85196849
121MP0002111_abnormal_tail_morphology0.84888521
122MP0001243_abnormal_dermal_layer0.84653592
123MP0005395_other_phenotype0.84347908
124MP0004272_abnormal_basement_membrane0.83919342
125MP0000343_altered_response_to0.83915163
126MP0003755_abnormal_palate_morphology0.83622053
127MP0005332_abnormal_amino_acid0.83594980
128MP0000703_abnormal_thymus_morphology0.82472802
129MP0001661_extended_life_span0.81792641
130MP0003786_premature_aging0.81537372
131MP0002796_impaired_skin_barrier0.81114434
132MP0002933_joint_inflammation0.80381164
133MP0004808_abnormal_hematopoietic_stem0.80249756
134MP0000579_abnormal_nail_morphology0.79487151
135MP0000313_abnormal_cell_death0.78983209
136MP0001929_abnormal_gametogenesis0.78923796
137MP0002092_abnormal_eye_morphology0.78877484
138MP0002877_abnormal_melanocyte_morpholog0.78566356
139MP0005384_cellular_phenotype0.78209667
140MP0003705_abnormal_hypodermis_morpholog0.78024974
141MP0002160_abnormal_reproductive_system0.77882012
142MP0005408_hypopigmentation0.77535760
143MP0005248_abnormal_Harderian_gland0.77397843
144MP0005171_absent_coat_pigmentation0.76996059
145MP0003252_abnormal_bile_duct0.76920507
146MP0010329_abnormal_lipoprotein_level0.76793139
147MP0003566_abnormal_cell_adhesion0.76674011
148MP0002751_abnormal_autonomic_nervous0.76577580
149MP0002210_abnormal_sex_determination0.76183060
150MP0003935_abnormal_craniofacial_develop0.74927061
151MP0004381_abnormal_hair_follicle0.73934441
152MP0003385_abnormal_body_wall0.73060710
153MP0001529_abnormal_vocalization0.72287839
154MP0000427_abnormal_hair_cycle0.71678939
155MP0001727_abnormal_embryo_implantation0.71623619
156MP0001145_abnormal_male_reproductive0.69870219
157MP0005187_abnormal_penis_morphology0.68933909
158MP0005501_abnormal_skin_physiology0.68640819
159MP0002060_abnormal_skin_morphology0.68501709
160MP0001299_abnormal_eye_distance/0.68488954
161MP0005220_abnormal_exocrine_pancreas0.67805229
162MP0000762_abnormal_tongue_morphology0.67381924
163MP0006036_abnormal_mitochondrial_physio0.67005709
164MP0003315_abnormal_perineum_morphology0.66983569
165MP0000653_abnormal_sex_gland0.66773200
166MP0005391_vision/eye_phenotype0.66153973
167MP0003221_abnormal_cardiomyocyte_apopto0.66096452
168MP0004233_abnormal_muscle_weight0.65531130
169MP0000432_abnormal_head_morphology0.64503476
170MP0000627_abnormal_mammary_gland0.63363119
171MP0010030_abnormal_orbit_morphology0.62199330
172MP0004215_abnormal_myocardial_fiber0.62033376
173MP0001915_intracranial_hemorrhage0.60017951
174MP0009780_abnormal_chondrocyte_physiolo0.59890759

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22747289
2Chromsome breakage (HP:0040012)4.18508368
3Abnormality of chromosome stability (HP:0003220)3.79763868
4Abnormality of the labia minora (HP:0012880)3.52366908
5Meckel diverticulum (HP:0002245)3.49240550
6Abnormality of cells of the erythroid lineage (HP:0012130)3.25610519
7Abnormality of the ileum (HP:0001549)3.24958239
8Thrombocytosis (HP:0001894)3.24620586
9Abnormality of the preputium (HP:0100587)3.19502496
10Abnormality of glycolysis (HP:0004366)3.18973782
11Abnormal number of erythroid precursors (HP:0012131)3.18674981
12Increased serum pyruvate (HP:0003542)3.17969868
13Reticulocytopenia (HP:0001896)3.12126880
14Nephroblastoma (Wilms tumor) (HP:0002667)3.03765914
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.99921701
16Birth length less than 3rd percentile (HP:0003561)2.99887007
17Embryonal renal neoplasm (HP:0011794)2.90039380
18Elevated erythrocyte sedimentation rate (HP:0003565)2.88948105
19Eczematoid dermatitis (HP:0000976)2.87381110
20Abnormal lung lobation (HP:0002101)2.80863820
21Autoimmune thrombocytopenia (HP:0001973)2.75429295
22Small intestinal stenosis (HP:0012848)2.74163023
23Duodenal stenosis (HP:0100867)2.74163023
24Rhabdomyosarcoma (HP:0002859)2.70044219
25Abnormality of the anterior horn cell (HP:0006802)2.70006775
26Degeneration of anterior horn cells (HP:0002398)2.70006775
27Autoimmune hemolytic anemia (HP:0001890)2.65466303
28Recurrent abscess formation (HP:0002722)2.64082145
29Recurrent gram-negative bacterial infections (HP:0005420)2.57193151
30Glioma (HP:0009733)2.56734896
31Multiple enchondromatosis (HP:0005701)2.45874537
32Acute encephalopathy (HP:0006846)2.45666725
33Abnormality of T cell number (HP:0011839)2.41886317
34Abnormality of the duodenum (HP:0002246)2.40905808
35Reduced antithrombin III activity (HP:0001976)2.40642651
36Recurrent bacterial skin infections (HP:0005406)2.38527453
37Ependymoma (HP:0002888)2.38472117
38Hypobetalipoproteinemia (HP:0003563)2.35812123
39Chronic otitis media (HP:0000389)2.35620339
40Medulloblastoma (HP:0002885)2.35156472
41Type I transferrin isoform profile (HP:0003642)2.35077523
42Abnormality of serum amino acid levels (HP:0003112)2.34711416
43Postnatal microcephaly (HP:0005484)2.33365064
44Megaloblastic anemia (HP:0001889)2.31543734
45Abnormality of T cell physiology (HP:0011840)2.31520305
46Pallor (HP:0000980)2.29554673
47Microvesicular hepatic steatosis (HP:0001414)2.29480250
48Oral leukoplakia (HP:0002745)2.29445014
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.27862270
50Neoplasm of the adrenal gland (HP:0100631)2.27615750
51Microglossia (HP:0000171)2.27300563
52Increased nuchal translucency (HP:0010880)2.26834063
53Acute necrotizing encephalopathy (HP:0006965)2.25216606
54Poor head control (HP:0002421)2.24035629
55T lymphocytopenia (HP:0005403)2.23178414
56Volvulus (HP:0002580)2.23161699
57Hypoglycemic seizures (HP:0002173)2.23065577
58Macrocytic anemia (HP:0001972)2.22364113
59Abnormality of T cells (HP:0002843)2.22224020
60Aplastic anemia (HP:0001915)2.22163902
61IgM deficiency (HP:0002850)2.21203529
62Abnormality of monocarboxylic acid metabolism (HP:0010996)2.21028587
63Agnosia (HP:0010524)2.17660927
64Bifid tongue (HP:0010297)2.16528842
65Neoplasm of the colon (HP:0100273)2.15755788
66Facial cleft (HP:0002006)2.15005861
67Abnormality of the carotid arteries (HP:0005344)2.12418135
68Recurrent viral infections (HP:0004429)2.11576788
69Abnormality of pyrimidine metabolism (HP:0004353)2.10012706
70Granulocytopenia (HP:0001913)2.09027146
71Myositis (HP:0100614)2.07866387
72Sloping forehead (HP:0000340)2.07232224
73Vacuolated lymphocytes (HP:0001922)2.06881757
74Colon cancer (HP:0003003)2.06411367
75Abnormality of the astrocytes (HP:0100707)2.06356647
76Astrocytoma (HP:0009592)2.06356647
77Nausea (HP:0002018)2.05568926
78Intrahepatic cholestasis (HP:0001406)2.05539656
79Abnormality of aromatic amino acid family metabolism (HP:0004338)2.05279073
80Abnormality of serine family amino acid metabolism (HP:0010894)2.05085679
81Abnormality of glycine metabolism (HP:0010895)2.05085679
82Combined immunodeficiency (HP:0005387)2.02888196
83Abnormal hemoglobin (HP:0011902)2.02332436
84Rough bone trabeculation (HP:0100670)2.02144649
85Pancreatic islet-cell hyperplasia (HP:0004510)2.01983561
86Hypoplasia of the thymus (HP:0000778)2.01937737
87IgG deficiency (HP:0004315)2.01258903
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01076739
89Abnormality of macrophages (HP:0004311)2.00629094
90Stenosis of the external auditory canal (HP:0000402)2.00374427
91B lymphocytopenia (HP:0010976)1.99895065
92Abnormality of B cell number (HP:0010975)1.99895065
93Hepatosplenomegaly (HP:0001433)1.99364285
94Recurrent bronchitis (HP:0002837)1.99296698
95Breast hypoplasia (HP:0003187)1.97632376
96Eosinophilia (HP:0001880)1.97539946
97Lipid accumulation in hepatocytes (HP:0006561)1.97356895
98Cerebral edema (HP:0002181)1.96826061
99Abnormality of iron homeostasis (HP:0011031)1.96434690
100Hypoglycemic coma (HP:0001325)1.96109913
101Hyperglycinuria (HP:0003108)1.95702007
102Spastic diplegia (HP:0001264)1.95679862
103Abnormal protein glycosylation (HP:0012346)1.94921457
104Abnormal glycosylation (HP:0012345)1.94921457
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94921457
106Abnormal protein N-linked glycosylation (HP:0012347)1.94921457
107Increased serum ferritin (HP:0003281)1.94804249
108Exertional dyspnea (HP:0002875)1.94318449
109Selective tooth agenesis (HP:0001592)1.93812187
110Myelodysplasia (HP:0002863)1.93644559
111Abnormal mitochondria in muscle tissue (HP:0008316)1.93180585
112Increased CSF lactate (HP:0002490)1.91781066
113Progressive macrocephaly (HP:0004481)1.90916391
114Ovarian neoplasm (HP:0100615)1.90231141
115Cortical dysplasia (HP:0002539)1.90072308
116Breast carcinoma (HP:0003002)1.89797473
117Stomatitis (HP:0010280)1.88862389
118Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88137555
119Abnormal auditory evoked potentials (HP:0006958)1.88124209
120Abnormality of the common coagulation pathway (HP:0010990)1.87552796
121Absent radius (HP:0003974)1.87279372
122Clubbing of toes (HP:0100760)1.85735959
123Abnormality of transition element cation homeostasis (HP:0011030)1.85412268
124Hyperinsulinemic hypoglycemia (HP:0000825)1.85390743
125Xanthomatosis (HP:0000991)1.85218934
126Petechiae (HP:0000967)1.84880761
127Hyperglycinemia (HP:0002154)1.84411427
12811 pairs of ribs (HP:0000878)1.83265411
129Secondary amenorrhea (HP:0000869)1.82620803
130Lymphoma (HP:0002665)1.81954198
131Uterine neoplasm (HP:0010784)1.81146082
132Symptomatic seizures (HP:0011145)1.81097638
133Embryonal neoplasm (HP:0002898)1.80845658
134Increased hepatocellular lipid droplets (HP:0006565)1.76877819
135Papillary thyroid carcinoma (HP:0002895)1.76158275
136Biliary tract neoplasm (HP:0100574)1.75089313
137Recurrent fungal infections (HP:0002841)1.74891806
138Abnormal cartilage morphology (HP:0002763)1.74388522
139Abnormality of methionine metabolism (HP:0010901)1.74127830
140Increased serum lactate (HP:0002151)1.73968092
141Leukocytosis (HP:0001974)1.73954552
142Hyperammonemia (HP:0001987)1.73954271
143Abnormality of alanine metabolism (HP:0010916)1.73724760
144Hyperalaninemia (HP:0003348)1.73724760
145Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73724760
146Increased muscle lipid content (HP:0009058)1.72669529
147Pustule (HP:0200039)1.72469916
148Abnormality of the vasculature of the conjunctiva (HP:0008054)1.70910964
149Urticaria (HP:0001025)1.70812305
150Absent forearm bone (HP:0003953)1.70703409
151Aplasia involving forearm bones (HP:0009822)1.70703409
152Pancytopenia (HP:0001876)1.70319664
153Horseshoe kidney (HP:0000085)1.70054060
154Triphalangeal thumb (HP:0001199)1.69882976
155Hepatic necrosis (HP:0002605)1.69559913
156Abnormality of cells of the lymphoid lineage (HP:0012140)1.69381575
157Severe combined immunodeficiency (HP:0004430)1.69336880
158Choanal atresia (HP:0000453)1.69263137
159Neoplasm of the small intestine (HP:0100833)1.68288707
160Overlapping toe (HP:0001845)1.67448203
161Vasculitis (HP:0002633)1.67162043
162Microretrognathia (HP:0000308)1.67132291
163Abnormality of eosinophils (HP:0001879)1.66360214
164Trismus (HP:0000211)1.65449087
165Prolonged partial thromboplastin time (HP:0003645)1.65231629
166Amaurosis fugax (HP:0100576)1.65010654
167Delayed CNS myelination (HP:0002188)1.64613313
168Methylmalonic acidemia (HP:0002912)1.64031122
169Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.63996057
170Thyroid carcinoma (HP:0002890)1.62110001
171Neutropenia (HP:0001875)1.62090827
172Leukodystrophy (HP:0002415)1.61472986
173Generalized aminoaciduria (HP:0002909)1.60683482
174Gangrene (HP:0100758)1.60417744
175Increased IgM level (HP:0003496)1.60046855
176Ectopic kidney (HP:0000086)1.59417571
177Abnormality of sulfur amino acid metabolism (HP:0004339)1.59032656
178Supernumerary spleens (HP:0009799)1.58234993
179Cafe-au-lait spot (HP:0000957)1.57661942

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.77169720
2EIF2AK13.26631433
3WEE13.06095221
4BMPR1B2.70480576
5TESK22.59711297
6MKNK22.45261890
7PIM22.43007113
8NME22.42384453
9PBK2.41780920
10BCKDK2.32026595
11ACVR1B2.31172517
12EIF2AK32.26627806
13TRIM281.93531877
14IRAK41.91198638
15BRSK21.88025214
16MST41.86517980
17FLT31.81377712
18VRK21.79702153
19CDC71.78803211
20ERN11.78730276
21RPS6KA41.77198727
22TESK11.65459122
23STK161.62588065
24STK101.62209866
25SRPK11.56446503
26LRRK21.55180602
27TLK11.49952981
28TYK21.48977130
29STK38L1.46429234
30DYRK31.46110932
31MAP4K11.44271671
32TAF11.39001295
33BCR1.37454504
34ERBB31.36612001
35CDK81.36297582
36VRK11.34031523
37FRK1.32146307
38BLK1.30977517
39KDR1.29784823
40MAP3K121.28507516
41SCYL21.25420963
42BRSK11.23748990
43TEC1.21292664
44TBK11.19997540
45TGFBR11.18696668
46TNIK1.17611545
47PDK21.16403913
48RPS6KB21.16348187
49ZAP701.16069317
50TTK1.12839668
51MAP3K141.12690393
52MAPKAPK31.12046771
53NEK21.11815840
54JAK31.11042350
55BTK1.07559597
56AURKB1.07094655
57TXK1.06161983
58PLK21.04448884
59ERBB41.03337618
60IKBKE1.02427862
61MAP3K81.01144253
62PIM11.00414147
63LIMK10.97733906
64EIF2AK20.95711777
65PASK0.94541659
66KIT0.94350345
67CDK60.93720765
68WNK30.93186286
69STK30.92961104
70MAP4K20.91641200
71PLK10.89934629
72CSF1R0.89722838
73STK40.89624688
74CDK40.89563291
75ALK0.88735795
76EPHA20.88423773
77ATM0.87626073
78CSNK1G10.87534813
79ATR0.87095842
80NME10.83371543
81ARAF0.82913652
82CSK0.82084577
83IKBKB0.80697013
84PLK40.80291659
85NEK90.78713835
86IRAK30.77718177
87NEK10.77279130
88PNCK0.75842503
89NLK0.75343853
90CDK90.74274090
91FGFR10.73973981
92LATS10.73803402
93YES10.72305818
94CDK70.71405391
95BRAF0.69030781
96TSSK60.68076067
97CSNK1A1L0.67593835
98LYN0.66977200
99CSNK1G30.66938704
100STK240.64964001
101LCK0.62430039
102TAOK30.61393847
103AURKA0.60126581
104MST1R0.60008087
105PAK40.58992979
106STK390.58357260
107LMTK20.57300266
108CHEK20.56553297
109NEK60.56233894
110MAP3K30.54736145
111FGFR40.54320594
112LATS20.53556759
113CSNK1G20.53523345
114RPS6KA50.53469217
115MAP2K30.52367071
116PLK30.51546839
117ABL20.51304426
118MET0.51206249
119SYK0.50855269
120CSNK1E0.50037020
121MKNK10.49760434
122JAK10.49284951
123ZAK0.48053645
124MELK0.47222280
125TRPM70.47200366
126CSNK2A20.46568800
127MAP3K40.46466466
128CDK30.46068220
129DAPK10.45727406
130ITK0.45166201
131CSNK2A10.43031291
132NUAK10.41762523
133DYRK1B0.41315090
134OXSR10.41178505
135CHEK10.40177691
136FGFR30.40109181
137PKN20.39703007
138CDK10.38974716
139SIK10.38749973
140EEF2K0.37001632
141PRKCE0.36694708
142BRD40.36224500
143IRAK10.35195035
144PRKDC0.34616176
145CASK0.34368074
146FER0.33175712
147CDK20.30342500
148DYRK20.29957843
149FGFR20.28901187
150MAP2K70.23778180
151MAPKAPK50.20424783

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.31737763
2Proteasome_Homo sapiens_hsa030502.78794317
3Ribosome_Homo sapiens_hsa030102.78683835
4Mismatch repair_Homo sapiens_hsa034302.70468866
5One carbon pool by folate_Homo sapiens_hsa006702.08054560
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07303005
7Protein export_Homo sapiens_hsa030601.98946702
8Base excision repair_Homo sapiens_hsa034101.91375160
9Folate biosynthesis_Homo sapiens_hsa007901.89213186
10Homologous recombination_Homo sapiens_hsa034401.83029843
11Caffeine metabolism_Homo sapiens_hsa002321.79551327
12Nucleotide excision repair_Homo sapiens_hsa034201.75745190
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75452906
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71783694
15Spliceosome_Homo sapiens_hsa030401.70221765
16Non-homologous end-joining_Homo sapiens_hsa034501.67842097
17RNA polymerase_Homo sapiens_hsa030201.63969139
18Pyrimidine metabolism_Homo sapiens_hsa002401.63248785
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57980134
20RNA transport_Homo sapiens_hsa030131.54901710
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45089740
22Cell cycle_Homo sapiens_hsa041101.43920135
23Antigen processing and presentation_Homo sapiens_hsa046121.40194385
24p53 signaling pathway_Homo sapiens_hsa041151.38037809
25Systemic lupus erythematosus_Homo sapiens_hsa053221.30027648
26Selenocompound metabolism_Homo sapiens_hsa004501.27929692
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.22426307
28Legionellosis_Homo sapiens_hsa051341.22278439
29* Pentose phosphate pathway_Homo sapiens_hsa000301.21200048
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20344626
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.19616870
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16998919
33mRNA surveillance pathway_Homo sapiens_hsa030151.13789239
34Glutathione metabolism_Homo sapiens_hsa004801.13319342
35Graft-versus-host disease_Homo sapiens_hsa053321.11854862
36Allograft rejection_Homo sapiens_hsa053301.08966573
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08161672
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06693696
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04746096
40Oxidative phosphorylation_Homo sapiens_hsa001901.03639754
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03356101
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01702691
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01508769
44Sulfur relay system_Homo sapiens_hsa041221.01058989
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00657134
46Oocyte meiosis_Homo sapiens_hsa041141.00651468
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99054620
48Peroxisome_Homo sapiens_hsa041460.98673575
49Herpes simplex infection_Homo sapiens_hsa051680.96916333
50Primary immunodeficiency_Homo sapiens_hsa053400.96466725
51Staphylococcus aureus infection_Homo sapiens_hsa051500.95393726
52Fatty acid degradation_Homo sapiens_hsa000710.94032047
53Parkinsons disease_Homo sapiens_hsa050120.93630630
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93319573
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.92834092
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91233916
57Measles_Homo sapiens_hsa051620.88391998
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.88348261
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.86811605
60Leishmaniasis_Homo sapiens_hsa051400.85405297
61RNA degradation_Homo sapiens_hsa030180.83377399
62Fanconi anemia pathway_Homo sapiens_hsa034600.83214912
63Other glycan degradation_Homo sapiens_hsa005110.81926442
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81639579
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81140918
66Histidine metabolism_Homo sapiens_hsa003400.78994069
67Basal transcription factors_Homo sapiens_hsa030220.78546024
68* Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77747817
69Epstein-Barr virus infection_Homo sapiens_hsa051690.77516670
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76961957
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.76373504
72Propanoate metabolism_Homo sapiens_hsa006400.76209368
73Viral carcinogenesis_Homo sapiens_hsa052030.76173019
74* Biosynthesis of amino acids_Homo sapiens_hsa012300.75872682
75* Carbon metabolism_Homo sapiens_hsa012000.75711514
76Butanoate metabolism_Homo sapiens_hsa006500.74892176
77Huntingtons disease_Homo sapiens_hsa050160.74739740
78Nitrogen metabolism_Homo sapiens_hsa009100.72940686
79Sulfur metabolism_Homo sapiens_hsa009200.72509619
80Hematopoietic cell lineage_Homo sapiens_hsa046400.71622623
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71473118
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67599564
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67491217
84Tryptophan metabolism_Homo sapiens_hsa003800.66554883
85beta-Alanine metabolism_Homo sapiens_hsa004100.63531097
86Malaria_Homo sapiens_hsa051440.62788121
87* Metabolic pathways_Homo sapiens_hsa011000.62289452
88TGF-beta signaling pathway_Homo sapiens_hsa043500.62144411
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62064330
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60400750
91Asthma_Homo sapiens_hsa053100.60250244
92Purine metabolism_Homo sapiens_hsa002300.60007002
93N-Glycan biosynthesis_Homo sapiens_hsa005100.59803591
94Renin-angiotensin system_Homo sapiens_hsa046140.59325191
95Complement and coagulation cascades_Homo sapiens_hsa046100.59086315
96Apoptosis_Homo sapiens_hsa042100.56901406
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55766466
98Shigellosis_Homo sapiens_hsa051310.54585521
99Fatty acid elongation_Homo sapiens_hsa000620.52597476
100Pyruvate metabolism_Homo sapiens_hsa006200.51942608
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.51677799
102Chemical carcinogenesis_Homo sapiens_hsa052040.50892217
103Autoimmune thyroid disease_Homo sapiens_hsa053200.49960134
104Fatty acid metabolism_Homo sapiens_hsa012120.49780666
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49404116
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49220317
107Alzheimers disease_Homo sapiens_hsa050100.48677283
108PPAR signaling pathway_Homo sapiens_hsa033200.47758569
109Influenza A_Homo sapiens_hsa051640.46230032
110Hippo signaling pathway_Homo sapiens_hsa043900.46045845
111Viral myocarditis_Homo sapiens_hsa054160.45511481
112Adherens junction_Homo sapiens_hsa045200.45251750
113Lysine degradation_Homo sapiens_hsa003100.43849239
114Arginine and proline metabolism_Homo sapiens_hsa003300.43521812
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43084311
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42721953
117Vitamin B6 metabolism_Homo sapiens_hsa007500.42559145
118Thyroid cancer_Homo sapiens_hsa052160.41698345
119Fat digestion and absorption_Homo sapiens_hsa049750.40998130
120Steroid biosynthesis_Homo sapiens_hsa001000.40644427
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40447168
122Pertussis_Homo sapiens_hsa051330.40135413
123Arginine biosynthesis_Homo sapiens_hsa002200.38291812
124Vitamin digestion and absorption_Homo sapiens_hsa049770.36198114
125Galactose metabolism_Homo sapiens_hsa000520.30082876
126Vibrio cholerae infection_Homo sapiens_hsa051100.29733121
127Tight junction_Homo sapiens_hsa045300.27894820
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27666066
129Circadian rhythm_Homo sapiens_hsa047100.26031364
130Retinol metabolism_Homo sapiens_hsa008300.23352053
131Starch and sucrose metabolism_Homo sapiens_hsa005000.21526497
132Wnt signaling pathway_Homo sapiens_hsa043100.20509517
133Alcoholism_Homo sapiens_hsa050340.19423343
134MicroRNAs in cancer_Homo sapiens_hsa052060.19338649
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18353521
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15843126
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.14882807

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