RPE65

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tyrosine metabolic process (GO:0006570)8.82482974
2* retinol metabolic process (GO:0042572)6.71980864
3regulation of rhodopsin mediated signaling pathway (GO:0022400)6.51294339
4retinoic acid metabolic process (GO:0042573)6.37323032
5rhodopsin mediated signaling pathway (GO:0016056)5.98951263
6camera-type eye morphogenesis (GO:0048593)5.95968350
7secondary metabolic process (GO:0019748)5.81371674
8mitochondrion distribution (GO:0048311)5.48123558
9phenol-containing compound biosynthetic process (GO:0046189)5.43418317
10* detection of light stimulus involved in visual perception (GO:0050908)5.39043623
11* detection of light stimulus involved in sensory perception (GO:0050962)5.39043623
12positive regulation of guanylate cyclase activity (GO:0031284)5.06451724
13* fat-soluble vitamin metabolic process (GO:0006775)4.97697058
14melanocyte differentiation (GO:0030318)4.91541143
15* cellular response to electrical stimulus (GO:0071257)4.70503297
16short-term memory (GO:0007614)4.59569572
17bicarbonate transport (GO:0015701)4.58872848
18regulation of guanylate cyclase activity (GO:0031282)4.53945674
19* phototransduction (GO:0007602)4.53832823
20pigment cell differentiation (GO:0050931)4.49085101
21diterpenoid biosynthetic process (GO:0016102)4.48553770
22ear development (GO:0043583)4.40206672
23presynaptic membrane assembly (GO:0097105)4.38895979
24* primary alcohol metabolic process (GO:0034308)4.28896672
25postsynaptic membrane organization (GO:0001941)4.21192685
26photoreceptor cell differentiation (GO:0046530)4.20604073
27eye photoreceptor cell differentiation (GO:0001754)4.20604073
28response to auditory stimulus (GO:0010996)4.12715284
29* detection of light stimulus (GO:0009583)4.07214383
30mechanosensory behavior (GO:0007638)3.98478876
31vascular smooth muscle contraction (GO:0014829)3.89780519
32cellular response to cholesterol (GO:0071397)3.89743038
33Notch signaling involved in heart development (GO:0061314)3.84265352
34positive regulation of neuroblast proliferation (GO:0002052)3.78506632
35eye photoreceptor cell development (GO:0042462)3.76841625
36photoreceptor cell development (GO:0042461)3.76169333
37cholesterol biosynthetic process (GO:0006695)3.74703193
38C4-dicarboxylate transport (GO:0015740)3.70238980
39gamma-aminobutyric acid transport (GO:0015812)3.69993478
40extracellular matrix assembly (GO:0085029)3.68286321
41ketone body metabolic process (GO:1902224)3.64794544
42retinal rod cell development (GO:0046548)3.64707671
43positive regulation of cGMP biosynthetic process (GO:0030828)3.62945493
44* phototransduction, visible light (GO:0007603)3.61323366
45* retinal metabolic process (GO:0042574)3.57294766
46presynaptic membrane organization (GO:0097090)3.50487047
47carnitine metabolic process (GO:0009437)3.50213719
48* retinoid metabolic process (GO:0001523)3.48334709
49* visual perception (GO:0007601)3.47546558
50serine family amino acid catabolic process (GO:0009071)3.46894815
51developmental pigmentation (GO:0048066)3.46395327
52cell morphogenesis involved in neuron differentiation (GO:0048667)3.45235149
53negative regulation of stress fiber assembly (GO:0051497)3.43641972
54* sensory perception of light stimulus (GO:0050953)3.43393751
55regulation of cGMP metabolic process (GO:0030823)3.42409733
56sterol biosynthetic process (GO:0016126)3.40998616
57photoreceptor cell maintenance (GO:0045494)3.40890459
58regulation of cGMP biosynthetic process (GO:0030826)3.37336736
59keratan sulfate catabolic process (GO:0042340)3.36554810
60regulation of skeletal muscle contraction (GO:0014819)3.31483862
61modified amino acid transport (GO:0072337)3.26623537
62positive regulation of cGMP metabolic process (GO:0030825)3.26122360
63* diterpenoid metabolic process (GO:0016101)3.25492366
64nonmotile primary cilium assembly (GO:0035058)3.23434391
65negative regulation of catenin import into nucleus (GO:0035414)3.22076304
66positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.21042192
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.19829240
68cell-cell junction maintenance (GO:0045217)3.18093251
69retina development in camera-type eye (GO:0060041)3.17560232
70icosanoid secretion (GO:0032309)3.16144147
71arachidonic acid secretion (GO:0050482)3.16144147
72terpenoid biosynthetic process (GO:0016114)3.14452492
73sodium-independent organic anion transport (GO:0043252)3.14203266
74response to lipoprotein particle (GO:0055094)3.10470118
75pigment biosynthetic process (GO:0046148)3.10301655
76neuroepithelial cell differentiation (GO:0060563)3.08651321
77isoprenoid biosynthetic process (GO:0008299)3.08561371
78positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.06953587
79cellular response to sterol (GO:0036315)3.06269560
80* detection of external stimulus (GO:0009581)3.06111984
81* detection of visible light (GO:0009584)3.06002506
82cysteine metabolic process (GO:0006534)3.04876753
83negative regulation of astrocyte differentiation (GO:0048712)3.01379042
84cornea development in camera-type eye (GO:0061303)3.01103671
85quaternary ammonium group transport (GO:0015697)3.00847917
86* vitamin A metabolic process (GO:0006776)23.1414615
87* detection of abiotic stimulus (GO:0009582)2.98393335
88* terpenoid metabolic process (GO:0006721)2.97417095
89embryonic viscerocranium morphogenesis (GO:0048703)2.97029596
90response to pheromone (GO:0019236)2.95303562
91chemokine-mediated signaling pathway (GO:0070098)2.95057656
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93661988
93negative regulation of oligodendrocyte differentiation (GO:0048715)2.92852979
94negative regulation of cardiac muscle tissue growth (GO:0055022)2.91502069
95negative regulation of heart growth (GO:0061117)2.91502069
96somatic stem cell division (GO:0048103)2.90280540
97neuron projection extension involved in neuron projection guidance (GO:1902284)2.88261541
98axon extension involved in axon guidance (GO:0048846)2.88261541
99neuron cell-cell adhesion (GO:0007158)2.87748691
100amino acid import (GO:0043090)2.87389621
101dermatan sulfate biosynthetic process (GO:0030208)2.86393149
102regulation of neurotransmitter uptake (GO:0051580)2.85240683
103chondroitin sulfate catabolic process (GO:0030207)2.84084579
104aggressive behavior (GO:0002118)2.83530475
105negative regulation of protein localization to cell surface (GO:2000009)2.80889816
106regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.80444661
107aromatic amino acid family metabolic process (GO:0009072)2.78740483
108L-amino acid import (GO:0043092)2.78532541
109negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.77432365
110neurotransmitter uptake (GO:0001504)2.76051939
111regulation of neuroblast proliferation (GO:1902692)2.75613457
112cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.75396243
113negative regulation of transcription regulatory region DNA binding (GO:2000678)2.74834888
114astrocyte differentiation (GO:0048708)2.70787322
115negative regulation of neurotransmitter transport (GO:0051589)2.70130111
116negative regulation of actin filament bundle assembly (GO:0032232)2.69159607
117L-serine metabolic process (GO:0006563)2.66316581
118icosanoid transport (GO:0071715)2.65548196
119fatty acid derivative transport (GO:1901571)2.65548196
120myelination in peripheral nervous system (GO:0022011)2.65430487
121peripheral nervous system axon ensheathment (GO:0032292)2.65430487
122negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.64321469
123branch elongation of an epithelium (GO:0060602)2.63702869
124cilium morphogenesis (GO:0060271)2.63211225
125cellular potassium ion homeostasis (GO:0030007)2.63175756
126amino-acid betaine metabolic process (GO:0006577)2.60869599
127negative regulation of vascular permeability (GO:0043116)2.60335609
128dermatan sulfate metabolic process (GO:0030205)2.60137916
129fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.59647568
130negative regulation of hormone biosynthetic process (GO:0032353)2.58475716
131negative regulation of hormone metabolic process (GO:0032351)2.58475716
132regulation of glucocorticoid metabolic process (GO:0031943)2.58109939
133otic vesicle formation (GO:0030916)2.57650364
134neuronal ion channel clustering (GO:0045161)2.57428729
135epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.55447248
136acidic amino acid transport (GO:0015800)2.54722726
137extracellular fibril organization (GO:0043206)2.54515266
138cell junction maintenance (GO:0034331)2.53314219
139eye morphogenesis (GO:0048592)2.49284429
140negative regulation of Rho protein signal transduction (GO:0035024)2.48816374
141leukotriene biosynthetic process (GO:0019370)2.43927632
142pigment metabolic process (GO:0042440)2.41981205
143* isoprenoid metabolic process (GO:0006720)2.40370815
144tonic smooth muscle contraction (GO:0014820)2.36641033
145organ formation (GO:0048645)2.36320701
146short-chain fatty acid metabolic process (GO:0046459)2.36040683
147skeletal muscle adaptation (GO:0043501)2.32358772
148negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.31342460
149axis elongation (GO:0003401)2.31174801
150mitochondrion localization (GO:0051646)2.30057855
151regulation of systemic arterial blood pressure (GO:0003073)2.28950612
152auditory behavior (GO:0031223)2.28125711
153phosphatidylinositol acyl-chain remodeling (GO:0036149)2.27405594
154artery smooth muscle contraction (GO:0014824)2.24016018
155collagen catabolic process (GO:0030574)2.18782654
156positive regulation of neural precursor cell proliferation (GO:2000179)2.17359555
157phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.15999313
158collagen metabolic process (GO:0032963)2.15745475
159regulation of steroid hormone biosynthetic process (GO:0090030)2.13445975
160negative regulation of response to reactive oxygen species (GO:1901032)2.13122944
161regulation of extracellular matrix disassembly (GO:0010715)2.10673005
162endothelial cell morphogenesis (GO:0001886)2.07094447
163layer formation in cerebral cortex (GO:0021819)2.05806876
164multicellular organismal macromolecule metabolic process (GO:0044259)2.05140069
165phenol-containing compound metabolic process (GO:0018958)2.04822927
166melanin biosynthetic process (GO:0042438)16.6680597
167melanin metabolic process (GO:0006582)15.2432565
168secondary metabolite biosynthetic process (GO:0044550)14.0774997
169protein-chromophore linkage (GO:0018298)13.5993313
170multicellular organismal catabolic process (GO:0044243)1.99281662
171columnar/cuboidal epithelial cell differentiation (GO:0002065)1.98727808
172phosphatidylserine acyl-chain remodeling (GO:0036150)1.97294777
173regulation of hydrogen peroxide-induced cell death (GO:1903205)1.96854804
174regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)1.96230561
175pyruvate metabolic process (GO:0006090)1.96229771
176embryonic camera-type eye development (GO:0031076)1.95420477
177* cellular aldehyde metabolic process (GO:0006081)1.94935033
178morphogenesis of an epithelial fold (GO:0060571)1.94127481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22554991
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.76958027
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83247914
4IGF1R_20145208_ChIP-Seq_DFB_Human2.67661478
5GATA1_26923725_Chip-Seq_HPCs_Mouse2.59419308
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32524540
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.29060619
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.23914457
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20125879
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10549733
11GBX2_23144817_ChIP-Seq_PC3_Human2.10118056
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06718295
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01375400
14PIAS1_25552417_ChIP-Seq_VCAP_Human1.91353751
15MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89271384
16TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88587195
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88569998
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88569998
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.87770329
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83600583
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80614043
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80503699
23CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78443711
24BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.77850598
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77185823
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.73445884
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72588889
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.67430838
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65940063
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.65207454
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65005982
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62995949
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.62983398
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61889192
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57826256
36TP53_18474530_ChIP-ChIP_U2OS_Human1.55657426
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54472603
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52966214
39* CBX2_27304074_Chip-Seq_ESCs_Mouse1.48876593
40AR_21572438_ChIP-Seq_LNCaP_Human1.45611654
41DROSHA_22980978_ChIP-Seq_HELA_Human1.44908323
42TAL1_26923725_Chip-Seq_HPCs_Mouse1.44746484
43LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44285893
44EWS_26573619_Chip-Seq_HEK293_Human1.42266752
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.40931875
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40131506
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38225357
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36205523
49* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36155488
50FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36106279
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34949758
52CJUN_26792858_Chip-Seq_BT549_Human1.32032002
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.31586736
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30526672
55CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29294765
56P53_22127205_ChIP-Seq_FIBROBLAST_Human1.29098475
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27996348
58AR_25329375_ChIP-Seq_VCAP_Human1.27641456
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.27138169
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26401879
61CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.25942631
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25280824
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25016159
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24160992
65CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.22847630
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22738005
67TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21895582
68TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21887971
69TCF4_22108803_ChIP-Seq_LS180_Human1.21343964
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19842083
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19176682
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18318668
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18039940
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17465381
75BCAT_22108803_ChIP-Seq_LS180_Human1.14972329
76* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14590520
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14484434
78TP53_16413492_ChIP-PET_HCT116_Human1.13534169
79RNF2_27304074_Chip-Seq_NSC_Mouse1.12183819
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.12111342
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11991319
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11957811
83EGR1_19032775_ChIP-ChIP_M12_Human1.11905728
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10956652
85P300_19829295_ChIP-Seq_ESCs_Human1.10434203
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08401232
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08320205
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.08118243
89* SMAD4_21799915_ChIP-Seq_A2780_Human1.07913757
90TAF15_26573619_Chip-Seq_HEK293_Human1.07685713
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07423010
92RUNX2_22187159_ChIP-Seq_PCA_Human1.06749001
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06410315
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.06334003
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06207570
96AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05502880
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05290209
98KDM2B_26808549_Chip-Seq_REH_Human1.04777088
99* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03776417
100JUN_21703547_ChIP-Seq_K562_Human1.03340776
101AHR_22903824_ChIP-Seq_MCF-7_Human1.03082774
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02456492
103TP63_17297297_ChIP-ChIP_HaCaT_Human1.02263643
104* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01063873
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00998336
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00773626
107SMAD4_21741376_ChIP-Seq_HESCs_Human1.00425899
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99993407
109* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97620391
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97321327
111RING1B_27294783_Chip-Seq_ESCs_Mouse0.97183666
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95773080
113STAT3_23295773_ChIP-Seq_U87_Human0.95648003
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95541038
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95447483
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91723333
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.91524145
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90673764
119WT1_19549856_ChIP-ChIP_CCG9911_Human0.90525331
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90488957
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90488957
122SOX2_21211035_ChIP-Seq_LN229_Gbm0.89967448
123FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89906092
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89693853
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89691859
126BP1_19119308_ChIP-ChIP_Hs578T_Human0.89183373
127TP63_23658742_ChIP-Seq_EP156T_Human0.89078742
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88505669
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88165732
130RXR_22158963_ChIP-Seq_LIVER_Mouse0.86832865
131RING1B_27294783_Chip-Seq_NPCs_Mouse0.85923471
132NANOG_18555785_Chip-Seq_ESCs_Mouse0.85704792
133KLF5_25053715_ChIP-Seq_YYC3_Human0.85580111
134POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84795168
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84750135
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84750135
137REST_18959480_ChIP-ChIP_MESCs_Mouse0.84472419
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.84132137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003011_delayed_dark_adaptation9.89661911
2MP0000372_irregular_coat_pigmentation7.03446732
3MP0005257_abnormal_intraocular_pressure6.55137711
4MP0003136_yellow_coat_color5.80447883
5MP0005171_absent_coat_pigmentation5.38835675
6MP0005423_abnormal_somatic_nervous3.94541345
7MP0001986_abnormal_taste_sensitivity3.74415648
8MP0002090_abnormal_vision3.63518542
9* MP0005551_abnormal_eye_electrophysiolog3.49856395
10* MP0005253_abnormal_eye_physiology3.15774957
11MP0005408_hypopigmentation3.06082547
12MP0000371_diluted_coat_color3.06077433
13MP0005409_darkened_coat_color2.88141949
14* MP0001324_abnormal_eye_pigmentation2.66609109
15* MP0004019_abnormal_vitamin_homeostasis2.42789774
16MP0000015_abnormal_ear_pigmentation2.36310238
17MP0006072_abnormal_retinal_apoptosis2.16807081
18MP0001984_abnormal_olfaction1.95019474
19* MP0005391_vision/eye_phenotype1.92754925
20MP0004381_abnormal_hair_follicle1.91432432
21MP0002075_abnormal_coat/hair_pigmentati1.90045783
22MP0005075_abnormal_melanosome_morpholog1.82613369
23MP0008438_abnormal_cutaneous_collagen1.70642291
24MP0002095_abnormal_skin_pigmentation1.63138034
25MP0005503_abnormal_tendon_morphology1.58956873
26MP0001186_pigmentation_phenotype1.57666688
27MP0004885_abnormal_endolymph1.56043892
28MP0001879_abnormal_lymphatic_vessel1.51057857
29MP0005377_hearing/vestibular/ear_phenot1.50063381
30MP0003878_abnormal_ear_physiology1.50063381
31MP0005197_abnormal_uvea_morphology1.47797503
32MP0000566_synostosis1.43303486
33MP0005275_abnormal_skin_tensile1.22632765
34MP0000516_abnormal_urinary_system1.19679144
35MP0005367_renal/urinary_system_phenotyp1.19679144
36MP0000778_abnormal_nervous_system1.18951800
37MP0001529_abnormal_vocalization1.14402501
38MP0002877_abnormal_melanocyte_morpholog1.10822266
39* MP0005195_abnormal_posterior_eye1.09534992
40MP0001502_abnormal_circadian_rhythm1.09477182
41MP0000462_abnormal_digestive_system1.09409168
42MP0002089_abnormal_postnatal_growth/wei1.09128057
43MP0004272_abnormal_basement_membrane1.06154281
44MP0000534_abnormal_ureter_morphology1.04539498
45MP0005248_abnormal_Harderian_gland1.03250974
46MP0005193_abnormal_anterior_eye1.00631398
47MP0009384_cardiac_valve_regurgitation0.99823920
48MP0004043_abnormal_pH_regulation0.98314539
49MP0002249_abnormal_larynx_morphology0.91814285
50* MP0002092_abnormal_eye_morphology0.84949950
51MP0002102_abnormal_ear_morphology0.84049592
52MP0008789_abnormal_olfactory_epithelium0.83122934
53MP0003942_abnormal_urinary_system0.79621894
54MP0010030_abnormal_orbit_morphology0.78177025
55MP0002653_abnormal_ependyma_morphology0.77751170
56MP0002938_white_spotting0.76260823
57MP0000920_abnormal_myelination0.74598282
58MP0005167_abnormal_blood-brain_barrier0.74314000
59MP0000579_abnormal_nail_morphology0.72225298
60MP0002282_abnormal_trachea_morphology0.72155465
61MP0006054_spinal_hemorrhage0.71068644
62MP0003690_abnormal_glial_cell0.69919440
63MP0000026_abnormal_inner_ear0.68751668
64MP0001764_abnormal_homeostasis0.68585371
65MP0004859_abnormal_synaptic_plasticity0.68382647
66MP0002822_catalepsy0.68014014
67MP0000762_abnormal_tongue_morphology0.67678019
68MP0005394_taste/olfaction_phenotype0.67190715
69MP0005499_abnormal_olfactory_system0.67190715
70MP0002572_abnormal_emotion/affect_behav0.67127793
71MP0003705_abnormal_hypodermis_morpholog0.66748835
72MP0002295_abnormal_pulmonary_circulatio0.65308574
73MP0001286_abnormal_eye_development0.64976108
74MP0002638_abnormal_pupillary_reflex0.64189117
75MP0005187_abnormal_penis_morphology0.64040043
76MP0000049_abnormal_middle_ear0.59476031
77MP0010234_abnormal_vibrissa_follicle0.59303778
78MP0002063_abnormal_learning/memory/cond0.58659254
79MP0005595_abnormal_vascular_smooth0.57776440
80MP0000751_myopathy0.57293824
81MP0004270_analgesia0.57138076
82MP0004130_abnormal_muscle_cell0.56937528
83MP0000569_abnormal_digit_pigmentation0.56809321
84MP0004036_abnormal_muscle_relaxation0.56616538
85MP0003631_nervous_system_phenotype0.56567837
86MP0000537_abnormal_urethra_morphology0.56165791
87MP0003755_abnormal_palate_morphology0.55989257
88MP0004142_abnormal_muscle_tone0.55654617
89MP0003938_abnormal_ear_development0.54378657
90MP0002233_abnormal_nose_morphology0.54042974
91MP0000631_abnormal_neuroendocrine_gland0.53752761
92MP0005360_urolithiasis0.53354196
93MP0000013_abnormal_adipose_tissue0.53272735
94MP0002697_abnormal_eye_size0.53145453
95MP0001293_anophthalmia0.52278344
96MP0001968_abnormal_touch/_nociception0.50951655
97MP0002067_abnormal_sensory_capabilities0.49960077
98MP0002127_abnormal_cardiovascular_syste0.49804350
99MP0010329_abnormal_lipoprotein_level0.49273177
100MP0004858_abnormal_nervous_system0.48668235
101MP0010678_abnormal_skin_adnexa0.47827146
102MP0000647_abnormal_sebaceous_gland0.47782414
103MP0001270_distended_abdomen0.47411431
104MP0002736_abnormal_nociception_after0.47203224
105MP0001177_atelectasis0.47118553
106MP0002272_abnormal_nervous_system0.46787315
107MP0001299_abnormal_eye_distance/0.46768121
108MP0002108_abnormal_muscle_morphology0.46473752
109MP0001963_abnormal_hearing_physiology0.46173687
110MP0009250_abnormal_appendicular_skeleto0.45879969
111MP0003283_abnormal_digestive_organ0.45246688
112MP0008961_abnormal_basal_metabolism0.45109752
113MP0003937_abnormal_limbs/digits/tail_de0.44617135
114MP0005623_abnormal_meninges_morphology0.44276154
115MP0002734_abnormal_mechanical_nocicepti0.43718911
116MP0003329_amyloid_beta_deposits0.43467098
117MP0003300_gastrointestinal_ulcer0.43080239
118MP0003385_abnormal_body_wall0.42097333
119* MP0002752_abnormal_somatic_nervous0.41916633
120MP0000428_abnormal_craniofacial_morphol0.40785865
121MP0000955_abnormal_spinal_cord0.40221167
122MP0000367_abnormal_coat/_hair0.38930969
123MP0003075_altered_response_to0.38872293
124MP0000767_abnormal_smooth_muscle0.38345788
125MP0004084_abnormal_cardiac_muscle0.37495983
126MP0009697_abnormal_copulation0.37489384
127MP0003279_aneurysm0.37341688
128MP0002332_abnormal_exercise_endurance0.35701308
129MP0002177_abnormal_outer_ear0.35302708
130MP0000467_abnormal_esophagus_morphology0.34753485
131MP0001486_abnormal_startle_reflex0.34712516
132MP0001346_abnormal_lacrimal_gland0.33108367
133MP0003941_abnormal_skin_development0.31974111
134MP0003453_abnormal_keratinocyte_physiol0.31676839
135MP0009780_abnormal_chondrocyte_physiolo0.29721307
136MP0010368_abnormal_lymphatic_system0.29509428
137MP0009840_abnormal_foam_cell0.28453144
138MP0005620_abnormal_muscle_contractility0.28365664
139MP0002133_abnormal_respiratory_system0.27912562
140MP0005388_respiratory_system_phenotype0.27912562
141MP0003634_abnormal_glial_cell0.27094034
142MP0000747_muscle_weakness0.26845683
143* MP0002882_abnormal_neuron_morphology0.26796814
144MP0003635_abnormal_synaptic_transmissio0.26297935
145MP0005508_abnormal_skeleton_morphology0.25988918
146MP0000383_abnormal_hair_follicle0.25282384
147MP0000465_gastrointestinal_hemorrhage0.25120435
148MP0008569_lethality_at_weaning0.25014356
149MP0001958_emphysema0.25013710
150MP0003633_abnormal_nervous_system0.23987333
151* MP0002229_neurodegeneration0.22654765
152MP0008875_abnormal_xenobiotic_pharmacok0.22483799
153MP0005166_decreased_susceptibility_to0.22187006
154MP0003115_abnormal_respiratory_system0.21926185
155MP0004215_abnormal_myocardial_fiber0.21903595
156MP0009046_muscle_twitch0.20984569
157MP0004484_altered_response_of0.19345389

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the fovea (HP:0007750)8.80682117
2Aplasia/Hypoplasia of the fovea (HP:0008060)8.80682117
3* Attenuation of retinal blood vessels (HP:0007843)7.84159807
4Constricted visual fields (HP:0001133)7.65909360
5Choroideremia (HP:0001139)7.06513393
6Aplasia/Hypoplasia of the macula (HP:0008059)6.79958061
7Aplasia/Hypoplasia affecting the retina (HP:0008061)6.32709449
8Ulnar claw (HP:0001178)6.31919200
9Blue irides (HP:0000635)6.24201099
10Action tremor (HP:0002345)5.94962500
11Bony spicule pigmentary retinopathy (HP:0007737)5.52714944
12Abolished electroretinogram (ERG) (HP:0000550)5.33507534
13Nonprogressive disorder (HP:0003680)5.27640226
14Abnormal rod and cone electroretinograms (HP:0008323)5.23876373
15Scotoma (HP:0000575)4.59007417
16Peripheral hypomyelination (HP:0007182)4.53219306
17Insidious onset (HP:0003587)4.48632666
18Termporal pattern (HP:0011008)4.48632666
19Ocular albinism (HP:0001107)4.40318221
20Segmental peripheral demyelination/remyelination (HP:0003481)4.09517947
21Iris hypopigmentation (HP:0007730)3.90839332
22Abnormal pupillary function (HP:0007686)3.89394886
23Corneal dystrophy (HP:0001131)3.88496609
24Split foot (HP:0001839)3.73594770
25Dyschromatopsia (HP:0007641)3.57421409
26Upper limb muscle weakness (HP:0003484)3.42618679
27Postural tremor (HP:0002174)3.31649971
28Congenital stationary night blindness (HP:0007642)3.28447415
29Progressive sensorineural hearing impairment (HP:0000408)3.13035198
30Increased CSF protein (HP:0002922)2.97864300
31Impaired proprioception (HP:0010831)2.90416989
32Systemic lupus erythematosus (HP:0002725)2.87538869
33* Type II diabetes mellitus (HP:0005978)2.86168658
34Pulmonary artery stenosis (HP:0004415)2.79916089
35Generalized hypopigmentation of hair (HP:0011358)2.76098505
36* Photophobia (HP:0000613)2.67642520
37Freckling (HP:0001480)2.65007176
38Macular degeneration (HP:0000608)2.58388839
39Short tibia (HP:0005736)2.49124049
40Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.45345818
41Hemiplegia (HP:0002301)2.35090244
42White forelock (HP:0002211)2.32728835
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.32002396
44Type 1 muscle fiber predominance (HP:0003803)2.28075145
45Hepatoblastoma (HP:0002884)2.24044811
46Steppage gait (HP:0003376)2.23689164
47Hammertoe (HP:0001765)2.19488971
48Nephrogenic diabetes insipidus (HP:0009806)2.18892580
49* Decreased central vision (HP:0007663)2.18240884
50Round ear (HP:0100830)2.16841210
51Gait imbalance (HP:0002141)2.14952348
52Exercise-induced muscle cramps (HP:0003710)2.13992029
53Broad metatarsal (HP:0001783)2.13517002
54Protrusio acetabuli (HP:0003179)2.12018899
55Congenital primary aphakia (HP:0007707)2.11747587
56Medial flaring of the eyebrow (HP:0010747)2.11600358
57Aplasia/Hypoplasia of the lens (HP:0008063)2.09809683
58True hermaphroditism (HP:0010459)2.03403907
59Hyperglycinuria (HP:0003108)2.01719457
60* Decreased electroretinogram (ERG) amplitude (HP:0000654)14.7346938
61Hypopigmentation of the fundus (HP:0007894)12.9550750
62Abnormality of the fovea (HP:0000493)12.4960640
63Patchy hypopigmentation of hair (HP:0011365)1.99480440
64Genital tract atresia (HP:0001827)1.97688818
65Vaginal atresia (HP:0000148)1.93675806
66Hypoplasia of the iris (HP:0007676)1.90609995
67Aplasia/Hypoplasia of the tongue (HP:0010295)1.89359501
68Flat cornea (HP:0007720)1.89309556
69Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.88782619
70Distal arthrogryposis (HP:0005684)1.87843212
71Central scotoma (HP:0000603)1.87808132
72Pendular nystagmus (HP:0012043)1.85523214
73Hyperglycinemia (HP:0002154)1.85301301
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.84470207
75Pancreatic fibrosis (HP:0100732)1.84224739
76Complement deficiency (HP:0004431)1.83685098
77Sensorimotor neuropathy (HP:0007141)1.79515990
78Abnormality of glycine metabolism (HP:0010895)1.76625802
79Abnormality of serine family amino acid metabolism (HP:0010894)1.76625802
80Abnormality of midbrain morphology (HP:0002418)1.73584533
81Molar tooth sign on MRI (HP:0002419)1.73584533
82Generalized hypopigmentation (HP:0007513)1.73528140
83Postaxial foot polydactyly (HP:0001830)1.72851127
84Chorioretinal atrophy (HP:0000533)1.72826970
85Progressive hearing impairment (HP:0001730)1.72637528
86Renal dysplasia (HP:0000110)1.70861792
87Polyphagia (HP:0002591)1.70739780
88Peripheral demyelination (HP:0011096)1.69789614
89Abnormal auditory evoked potentials (HP:0006958)1.68479977
90Decreased lacrimation (HP:0000633)1.67352573
91Postaxial hand polydactyly (HP:0001162)1.66504472
92Aortic dissection (HP:0002647)1.62247155
93Alacrima (HP:0000522)1.61938202
94Vertebral compression fractures (HP:0002953)1.59898302
95Glomerulonephritis (HP:0000099)1.59711983
96Foot dorsiflexor weakness (HP:0009027)1.59177785
97Posterior subcapsular cataract (HP:0007787)1.58193813
98Hypermetropia (HP:0000540)1.57824691
99Absent frontal sinuses (HP:0002688)1.57798005
100Hypoalphalipoproteinemia (HP:0003233)1.57274537
101Neurofibrillary tangles (HP:0002185)1.56245101
102Nemaline bodies (HP:0003798)1.54945971
103Diplopia (HP:0000651)1.54929807
104Abnormality of binocular vision (HP:0011514)1.54929807
105Microglossia (HP:0000171)1.54615747
106Retinal atrophy (HP:0001105)1.53825343
107Absent toe (HP:0010760)1.53158368
108Occipital encephalocele (HP:0002085)1.53091146
109Cortical dysplasia (HP:0002539)1.52587718
110Abnormality of the foot musculature (HP:0001436)1.52057254
111Muscle fiber inclusion bodies (HP:0100299)1.51274317
112Abnormality of the labia minora (HP:0012880)1.49893074
113Coronal craniosynostosis (HP:0004440)1.48930534
114Preaxial foot polydactyly (HP:0001841)1.48123995
115Bronchomalacia (HP:0002780)1.48108883
116Calcaneovalgus deformity (HP:0001848)1.47728145
117Abnormality of the anterior chamber (HP:0000593)1.47025710
118Cerebral aneurysm (HP:0004944)1.46957423
119Pigmentary retinal degeneration (HP:0001146)1.44637613
120* Wide nasal bridge (HP:0000431)1.43202508
121Intrahepatic cholestasis (HP:0001406)1.41647485
122Heterochromia iridis (HP:0001100)1.40933395
123Exercise-induced myalgia (HP:0003738)1.39909069
124Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.34028456
125Cerebral inclusion bodies (HP:0100314)1.30510429
126Hyperlipoproteinemia (HP:0010980)1.27882384
127Absent phalangeal crease (HP:0006109)1.27335649
128Annular pancreas (HP:0001734)1.27151067
129Premature rupture of membranes (HP:0001788)1.26921196
130Deformed tarsal bones (HP:0008119)1.26679568
131Aortic aneurysm (HP:0004942)1.26611290
132Aplasia involving bones of the upper limbs (HP:0009823)1.25614683
133Aplasia of the phalanges of the hand (HP:0009802)1.25614683
134Aplasia involving bones of the extremities (HP:0009825)1.25614683
135Optic disc pallor (HP:0000543)1.24895797
136Right ventricular cardiomyopathy (HP:0011663)1.21411950
137Shallow orbits (HP:0000586)1.20844741
138Abnormality of macular pigmentation (HP:0008002)1.19440716
139Slender build (HP:0001533)1.19369027
140Hemiparesis (HP:0001269)1.19269369
141Hypoventilation (HP:0002791)1.16394289
142Cone-rod dystrophy (HP:0000548)1.16331195
143Ulnar deviation of the wrist (HP:0003049)1.16020314
144Arterial tortuosity (HP:0005116)1.15154317
145Increased variability in muscle fiber diameter (HP:0003557)1.14884722
146Pallor (HP:0000980)1.13841544
147Melanoma (HP:0002861)1.12375606
148Striae distensae (HP:0001065)1.11786744
149Focal motor seizures (HP:0011153)1.11538770
150Cutaneous melanoma (HP:0012056)1.11478915
151Vascular tortuosity (HP:0004948)1.11335677
152Retinitis pigmentosa (HP:0000510)1.11289545
153Hypoglycemic seizures (HP:0002173)1.11136141
154Xanthomatosis (HP:0000991)1.10959182
155Tarsal synostosis (HP:0008368)1.07907791
156Abnormal finger flexion creases (HP:0006143)1.07808841
157Subacute progressive viral hepatitis (HP:0006572)1.05847375
158* Keratoconus (HP:0000563)1.05402138
159* Increased corneal curvature (HP:0100692)1.05402138
160Mitral valve prolapse (HP:0001634)1.05239571
161Amyloidosis (HP:0011034)1.04986920
162Congenital sensorineural hearing impairment (HP:0008527)1.04507875
163Frequent falls (HP:0002359)1.03810031
164Atrophic scars (HP:0001075)1.03226001
165Bilateral sensorineural hearing impairment (HP:0008619)1.02087583
166Megalencephaly (HP:0001355)1.00945658
167Cardiovascular calcification (HP:0011915)0.98420105
168Difficulty running (HP:0009046)0.97948764
169Abnormality of skeletal muscle fiber size (HP:0012084)0.97756740

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.04124442
2CASK4.98638426
3EPHA34.13098055
4MST1R3.72667180
5PKN23.33395569
6MST42.77508931
7LATS12.67912570
8EPHA42.60688793
9PDK22.57326853
10BCKDK2.56881415
11FGFR22.43310168
12PBK2.36470647
13DDR22.26423372
14FRK2.11771346
15MET2.09123019
16PRKD32.04821583
17TTN2.04033848
18NEK91.77236065
19FLT31.73842515
20BMPR1B1.65662070
21PIK3CG1.63700247
22WNK41.54572833
23TRIB31.51769767
24STK38L1.50300599
25PHKG11.50188339
26PHKG21.50188339
27TGFBR21.45230466
28BCR1.45194441
29BMX1.38796938
30PTK61.38326873
31PLK21.38213490
32SIK11.38213015
33MARK31.36924141
34TGFBR11.36823740
35MUSK1.35249754
36CCNB11.34005730
37STK241.32256748
38GRK11.31888214
39LMTK21.31566543
40NTRK11.29402738
41TIE11.25274142
42PRKCH1.24704607
43PDGFRA1.16984866
44NTRK31.16760090
45ERBB31.11574237
46CSNK1G21.10921316
47STK391.10201621
48PTK2B1.08918775
49RIPK11.08558373
50CSNK1G11.07055884
51MAP3K41.01272020
52LRRK21.00039859
53CSNK1A1L0.98732338
54RET0.97767409
55PDK10.97398422
56IRAK10.95025713
57MAPK130.94495003
58MAPK120.91679813
59OXSR10.88846543
60MAP2K70.87732159
61WNK30.87318794
62PIK3CA0.86965525
63GSK3A0.86688497
64CSNK1G30.86345019
65MINK10.85836861
66PIM20.85803996
67STK30.83931070
68PDPK10.79425655
69MAP3K70.77624304
70EPHB10.75912464
71PRKD20.75862870
72RIPK40.75797134
73PKN10.74211448
74EIF2AK10.74125459
75MYLK0.73376062
76MAP3K90.71897210
77PAK30.71501287
78MAP3K20.68710208
79CSNK1D0.68634436
80TNIK0.68321803
81PINK10.67872956
82PDGFRB0.67567437
83SCYL20.67282281
84ERBB40.66937988
85MAPK70.65859505
86PDK30.65204068
87PDK40.65204068
88MAP3K130.64994196
89MOS0.64553633
90DYRK1A0.63946129
91PRKCE0.63655613
92DYRK20.63553920
93CDK50.62651330
94ROCK20.60184646
95FGR0.59059355
96MKNK20.59021856
97NTRK20.58676714
98CAMK2D0.57795931
99EIF2AK30.57201048
100ERBB20.56194016
101PRKD10.56161257
102ADRBK10.55635670
103AKT20.54783733
104PRKCG0.53349295
105JAK10.53260848
106LIMK10.52800236
107BMPR20.52681239
108NEK60.52498057
109PAK20.51609019
110UHMK10.51135571
111INSRR0.50213428
112CAMK2G0.49493837
113PRKCQ0.48448025
114NLK0.48117346
115PAK60.47983756
116MARK10.46589096
117CAMK2B0.44706688
118LATS20.44671591
119FGFR10.44665338
120CAMKK10.43813486
121HIPK20.43674709
122MAPK150.43560595
123CDK80.42882892
124FYN0.42874010
125DMPK0.42559492
126SRC0.42378593
127SGK4940.41930472
128SGK2230.41930472
129EGFR0.41803149
130JAK20.41514206
131IRAK30.38403608
132INSR0.38319283
133WEE10.37935705
134RPS6KA40.37435271
135IGF1R0.35953426
136EPHB20.35573031
137FER0.35311226
138MAPKAPK50.35012918
139MAP4K20.34615524
140CAMK10.33489390
141CAMK2A0.32346169
142NUAK10.31808251
143MAP2K40.31309573
144ROCK10.30372466
145PRKCB0.30072205
146PRKACA0.29937880
147CDC42BPA0.29513232
148SGK20.28437610
149CSNK1A10.26056544

Predicted pathways (KEGG)

RankGene SetZ-score
1Tyrosine metabolism_Homo sapiens_hsa003504.91543889
2* Retinol metabolism_Homo sapiens_hsa008304.08720059
3Phototransduction_Homo sapiens_hsa047443.97573449
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.72846259
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.69925815
6Vitamin digestion and absorption_Homo sapiens_hsa049773.68513330
7Nitrogen metabolism_Homo sapiens_hsa009103.65086190
8Phenylalanine metabolism_Homo sapiens_hsa003602.33245621
9Melanogenesis_Homo sapiens_hsa049162.05824427
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92815927
11Bile secretion_Homo sapiens_hsa049761.85321453
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.74607802
13Histidine metabolism_Homo sapiens_hsa003401.70000493
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69952089
15Chemical carcinogenesis_Homo sapiens_hsa052041.65562134
16Olfactory transduction_Homo sapiens_hsa047401.56021198
17Linoleic acid metabolism_Homo sapiens_hsa005911.50676222
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48663830
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42885509
20Gastric acid secretion_Homo sapiens_hsa049711.38017681
21Salivary secretion_Homo sapiens_hsa049701.36736097
22beta-Alanine metabolism_Homo sapiens_hsa004101.33046399
23Peroxisome_Homo sapiens_hsa041461.32763814
24Protein export_Homo sapiens_hsa030601.31031972
25Tight junction_Homo sapiens_hsa045301.26761959
26Basal cell carcinoma_Homo sapiens_hsa052171.21102452
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18298878
28Renin secretion_Homo sapiens_hsa049241.13872579
29Circadian rhythm_Homo sapiens_hsa047101.13718705
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.12412815
31ECM-receptor interaction_Homo sapiens_hsa045121.10255140
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.09981300
33Circadian entrainment_Homo sapiens_hsa047131.03286053
34Fatty acid degradation_Homo sapiens_hsa000711.01621396
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99478054
36Fatty acid biosynthesis_Homo sapiens_hsa000610.97595198
37Ether lipid metabolism_Homo sapiens_hsa005650.97401154
38Amphetamine addiction_Homo sapiens_hsa050310.96105794
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90815770
40Long-term potentiation_Homo sapiens_hsa047200.90235229
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88478463
42Fat digestion and absorption_Homo sapiens_hsa049750.88213070
43Arginine biosynthesis_Homo sapiens_hsa002200.87479866
44Glioma_Homo sapiens_hsa052140.87428555
45Fatty acid metabolism_Homo sapiens_hsa012120.86269545
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83829968
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83688801
48Hedgehog signaling pathway_Homo sapiens_hsa043400.81978582
49Hippo signaling pathway_Homo sapiens_hsa043900.80919386
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78766385
51Dilated cardiomyopathy_Homo sapiens_hsa054140.77712121
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77297032
53GABAergic synapse_Homo sapiens_hsa047270.76859814
54Sulfur relay system_Homo sapiens_hsa041220.73341706
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72022441
56Focal adhesion_Homo sapiens_hsa045100.71034886
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70787556
58Arachidonic acid metabolism_Homo sapiens_hsa005900.70480648
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69556202
60Pancreatic secretion_Homo sapiens_hsa049720.68062441
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67512246
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67088283
63Tryptophan metabolism_Homo sapiens_hsa003800.66592940
64Folate biosynthesis_Homo sapiens_hsa007900.66305015
65TGF-beta signaling pathway_Homo sapiens_hsa043500.65825447
66Protein digestion and absorption_Homo sapiens_hsa049740.65732632
67Calcium signaling pathway_Homo sapiens_hsa040200.65321767
68Vitamin B6 metabolism_Homo sapiens_hsa007500.62988818
69Taste transduction_Homo sapiens_hsa047420.62198872
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61709876
71Steroid biosynthesis_Homo sapiens_hsa001000.61136629
72Glutamatergic synapse_Homo sapiens_hsa047240.61127149
73Wnt signaling pathway_Homo sapiens_hsa043100.61085656
74Axon guidance_Homo sapiens_hsa043600.59812430
75Oxidative phosphorylation_Homo sapiens_hsa001900.58925547
76Gap junction_Homo sapiens_hsa045400.58889311
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58359979
78Butanoate metabolism_Homo sapiens_hsa006500.58078772
79Oxytocin signaling pathway_Homo sapiens_hsa049210.57770081
80Glucagon signaling pathway_Homo sapiens_hsa049220.56864341
81Amoebiasis_Homo sapiens_hsa051460.56863898
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56550344
83Regulation of autophagy_Homo sapiens_hsa041400.56469160
84ABC transporters_Homo sapiens_hsa020100.56350467
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56198495
86Ras signaling pathway_Homo sapiens_hsa040140.56148618
87Dopaminergic synapse_Homo sapiens_hsa047280.56132900
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55522401
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55430131
90Malaria_Homo sapiens_hsa051440.55098328
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54465634
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54250748
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.53866187
94Arginine and proline metabolism_Homo sapiens_hsa003300.53644751
95Proteoglycans in cancer_Homo sapiens_hsa052050.53442950
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.52796541
97Propanoate metabolism_Homo sapiens_hsa006400.52674428
98Morphine addiction_Homo sapiens_hsa050320.52530042
99GnRH signaling pathway_Homo sapiens_hsa049120.52501652
100Parkinsons disease_Homo sapiens_hsa050120.49882654
101Rap1 signaling pathway_Homo sapiens_hsa040150.49615377
102Adherens junction_Homo sapiens_hsa045200.49477984
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49268936
104Estrogen signaling pathway_Homo sapiens_hsa049150.49186163
105cAMP signaling pathway_Homo sapiens_hsa040240.49160700
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49132485
107Cholinergic synapse_Homo sapiens_hsa047250.48860149
108Synaptic vesicle cycle_Homo sapiens_hsa047210.48379607
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.48033341
110Notch signaling pathway_Homo sapiens_hsa043300.47321235
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47195196
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46961251
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45712248
114Pyruvate metabolism_Homo sapiens_hsa006200.44527312
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44319765
116Collecting duct acid secretion_Homo sapiens_hsa049660.43900568
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43462940
118Starch and sucrose metabolism_Homo sapiens_hsa005000.42850755
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42448277
120Pertussis_Homo sapiens_hsa051330.42296050
121Huntingtons disease_Homo sapiens_hsa050160.41871662
122Dorso-ventral axis formation_Homo sapiens_hsa043200.41751152
123Cardiac muscle contraction_Homo sapiens_hsa042600.41746123
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41486569
125Insulin secretion_Homo sapiens_hsa049110.40555942
126Cocaine addiction_Homo sapiens_hsa050300.39560741
127Vibrio cholerae infection_Homo sapiens_hsa051100.39454440
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38605069
129Sulfur metabolism_Homo sapiens_hsa009200.38458335
130Caffeine metabolism_Homo sapiens_hsa002320.38350214
131Complement and coagulation cascades_Homo sapiens_hsa046100.38344161
132Alzheimers disease_Homo sapiens_hsa050100.36959538
133Staphylococcus aureus infection_Homo sapiens_hsa051500.34969251
134Glutathione metabolism_Homo sapiens_hsa004800.34641344
135Renal cell carcinoma_Homo sapiens_hsa052110.34624075
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34386046
137PPAR signaling pathway_Homo sapiens_hsa033200.34222287
138Thyroid hormone synthesis_Homo sapiens_hsa049180.33813762
139Prion diseases_Homo sapiens_hsa050200.31247740
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30712736
141Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30635066
142Metabolic pathways_Homo sapiens_hsa011000.30254434
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29945289
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29668703
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.29117335
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28526473
147Fatty acid elongation_Homo sapiens_hsa000620.28468039
148Nicotine addiction_Homo sapiens_hsa050330.27406186
149Carbon metabolism_Homo sapiens_hsa012000.27311090

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