

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.31371995 |
| 2 | ribosomal small subunit assembly (GO:0000028) | 5.01030570 |
| 3 | chaperone-mediated protein transport (GO:0072321) | 4.72457432 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 4.46148514 |
| 5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.46148514 |
| 6 | DNA deamination (GO:0045006) | 4.45703557 |
| 7 | maturation of SSU-rRNA (GO:0030490) | 4.43257630 |
| 8 | regulation of mitochondrial translation (GO:0070129) | 4.26063552 |
| 9 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.24455470 |
| 10 | viral transcription (GO:0019083) | 4.24434062 |
| 11 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.23191271 |
| 12 | translational termination (GO:0006415) | 4.22209773 |
| 13 | ribosomal small subunit biogenesis (GO:0042274) | 4.20470483 |
| 14 | DNA replication initiation (GO:0006270) | 4.16325859 |
| 15 | nucleobase biosynthetic process (GO:0046112) | 4.16144672 |
| 16 | purine nucleobase biosynthetic process (GO:0009113) | 4.10977171 |
| 17 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.10260271 |
| 18 | formation of translation preinitiation complex (GO:0001731) | 4.06698456 |
| 19 | DNA strand elongation (GO:0022616) | 4.04342334 |
| 20 | CENP-A containing nucleosome assembly (GO:0034080) | 4.00390104 |
| 21 | ribosomal large subunit biogenesis (GO:0042273) | 3.97662909 |
| 22 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.96367188 |
| 23 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.94887513 |
| 24 | chromatin remodeling at centromere (GO:0031055) | 3.89841981 |
| 25 | DNA replication checkpoint (GO:0000076) | 3.89744343 |
| 26 | ribosome biogenesis (GO:0042254) | 3.88675526 |
| 27 | negative regulation of ligase activity (GO:0051352) | 3.87603915 |
| 28 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.87603915 |
| 29 | translational elongation (GO:0006414) | 3.83054496 |
| 30 | establishment of integrated proviral latency (GO:0075713) | 3.79148579 |
| 31 | telomere maintenance via recombination (GO:0000722) | 3.78068008 |
| 32 | ribosome assembly (GO:0042255) | 3.76564967 |
| 33 | translational initiation (GO:0006413) | 3.75894004 |
| 34 | kinetochore organization (GO:0051383) | 3.72099422 |
| 35 | respiratory electron transport chain (GO:0022904) | 3.71527046 |
| 36 | DNA unwinding involved in DNA replication (GO:0006268) | 3.70200968 |
| 37 | mitotic metaphase plate congression (GO:0007080) | 3.69678345 |
| 38 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.68448251 |
| 39 | DNA replication-independent nucleosome organization (GO:0034724) | 3.63429477 |
| 40 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.63429477 |
| 41 | electron transport chain (GO:0022900) | 3.62910419 |
| 42 | cullin deneddylation (GO:0010388) | 3.62112894 |
| 43 | cotranslational protein targeting to membrane (GO:0006613) | 3.58016718 |
| 44 | protein targeting to ER (GO:0045047) | 3.57092417 |
| 45 | protein targeting to mitochondrion (GO:0006626) | 3.56197245 |
| 46 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.55337394 |
| 47 | mitotic recombination (GO:0006312) | 3.55311199 |
| 48 | IMP biosynthetic process (GO:0006188) | 3.55121365 |
| 49 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.54772496 |
| 50 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.52609184 |
| 51 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.52556892 |
| 52 | protein deneddylation (GO:0000338) | 3.51503333 |
| 53 | proteasome assembly (GO:0043248) | 3.51335080 |
| 54 | mitotic nuclear envelope disassembly (GO:0007077) | 3.51034640 |
| 55 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.50590257 |
| 56 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.50590257 |
| 57 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.50590257 |
| 58 | * rRNA processing (GO:0006364) | 3.49255368 |
| 59 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.48984096 |
| 60 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.48984096 |
| 61 | protein localization to kinetochore (GO:0034501) | 3.48351794 |
| 62 | kinetochore assembly (GO:0051382) | 3.46430127 |
| 63 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.44049473 |
| 64 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.42759786 |
| 65 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.42759786 |
| 66 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.42509021 |
| 67 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.42509021 |
| 68 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.41872874 |
| 69 | positive regulation of ligase activity (GO:0051351) | 3.41134435 |
| 70 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.39284379 |
| 71 | spliceosomal snRNP assembly (GO:0000387) | 3.39008139 |
| 72 | protein localization to endoplasmic reticulum (GO:0070972) | 3.37761447 |
| 73 | * rRNA metabolic process (GO:0016072) | 3.37685953 |
| 74 | telomere maintenance via telomere lengthening (GO:0010833) | 3.37554544 |
| 75 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.36977210 |
| 76 | histone mRNA metabolic process (GO:0008334) | 3.35419479 |
| 77 | protein complex biogenesis (GO:0070271) | 3.34838001 |
| 78 | protein localization to mitochondrion (GO:0070585) | 3.28482439 |
| 79 | cellular protein complex disassembly (GO:0043624) | 3.26713590 |
| 80 | metaphase plate congression (GO:0051310) | 3.26623388 |
| 81 | DNA double-strand break processing (GO:0000729) | 3.25722754 |
| 82 | rRNA methylation (GO:0031167) | 3.24983016 |
| 83 | viral life cycle (GO:0019058) | 3.24534636 |
| 84 | pseudouridine synthesis (GO:0001522) | 3.24433991 |
| 85 | histone exchange (GO:0043486) | 3.24395115 |
| 86 | nuclear pore organization (GO:0006999) | 3.24352680 |
| 87 | establishment of protein localization to mitochondrion (GO:0072655) | 3.23844982 |
| 88 | IMP metabolic process (GO:0046040) | 3.23059960 |
| 89 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.22887050 |
| 90 | nuclear envelope disassembly (GO:0051081) | 3.21062894 |
| 91 | membrane disassembly (GO:0030397) | 3.21062894 |
| 92 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.20649397 |
| 93 | oxidative phosphorylation (GO:0006119) | 3.18798355 |
| 94 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.18248500 |
| 95 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.18248500 |
| 96 | rRNA modification (GO:0000154) | 3.17916916 |
| 97 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.17111399 |
| 98 | regulation of spindle organization (GO:0090224) | 3.16166546 |
| 99 | protein localization to chromosome, centromeric region (GO:0071459) | 3.11900866 |
| 100 | regulation of ligase activity (GO:0051340) | 3.10191180 |
| 101 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.08761995 |
| 102 | termination of RNA polymerase II transcription (GO:0006369) | 3.08622940 |
| 103 | translation (GO:0006412) | 3.07903986 |
| 104 | maturation of 5.8S rRNA (GO:0000460) | 3.07311553 |
| 105 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.07184013 |
| 106 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.07162978 |
| 107 | NADH dehydrogenase complex assembly (GO:0010257) | 3.07162978 |
| 108 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.07162978 |
| 109 | DNA ligation (GO:0006266) | 3.04662384 |
| 110 | establishment of viral latency (GO:0019043) | 3.03685833 |
| 111 | nuclear pore complex assembly (GO:0051292) | 3.02269745 |
| 112 | spliceosomal complex assembly (GO:0000245) | 2.99785568 |
| 113 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.99620087 |
| 114 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.98174159 |
| 115 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.97257837 |
| 116 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.96918363 |
| 117 | viral mRNA export from host cell nucleus (GO:0046784) | 2.96031058 |
| 118 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.94852529 |
| 119 | protein complex disassembly (GO:0043241) | 2.94405296 |
| 120 | establishment of chromosome localization (GO:0051303) | 2.94209133 |
| 121 | cellular component biogenesis (GO:0044085) | 2.93279553 |
| 122 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.90323887 |
| 123 | termination of RNA polymerase III transcription (GO:0006386) | 2.89202494 |
| 124 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.89202494 |
| 125 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.87661995 |
| 126 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.82506744 |
| 127 | folic acid metabolic process (GO:0046655) | 2.82485328 |
| 128 | mRNA catabolic process (GO:0006402) | 2.82043219 |
| 129 | macromolecular complex disassembly (GO:0032984) | 2.81465236 |
| 130 | RNA splicing, via transesterification reactions (GO:0000375) | 2.79160880 |
| 131 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.78764462 |
| 132 | RNA catabolic process (GO:0006401) | 2.77889000 |
| 133 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.77263851 |
| 134 | mRNA splicing, via spliceosome (GO:0000398) | 2.77263851 |
| 135 | chromatin assembly or disassembly (GO:0006333) | 2.77124448 |
| 136 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.76912214 |
| 137 | cell cycle G1/S phase transition (GO:0044843) | 2.76912214 |
| 138 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.73449208 |
| 139 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.73449208 |
| 140 | negative regulation of sister chromatid segregation (GO:0033046) | 2.73449208 |
| 141 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.73449208 |
| 142 | telomere maintenance (GO:0000723) | 2.72574762 |
| 143 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.72404952 |
| 144 | negative regulation of chromosome segregation (GO:0051985) | 2.71609123 |
| 145 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.71547497 |
| 146 | telomere organization (GO:0032200) | 2.71280042 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.19544151 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.32430481 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.58187518 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.45297904 |
| 5 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.36919482 |
| 6 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.33516141 |
| 7 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.08900573 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.08452880 |
| 9 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.95978924 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.86906691 |
| 11 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.84536235 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.81243497 |
| 13 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.80306752 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.77491302 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.70587869 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.42467289 |
| 17 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.41741971 |
| 18 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.40070793 |
| 19 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.29682450 |
| 20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.27938516 |
| 21 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.18483265 |
| 22 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.10329192 |
| 23 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.07953659 |
| 24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.07096119 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.05700021 |
| 26 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.02231322 |
| 27 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.89236794 |
| 28 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.88740777 |
| 29 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.86891073 |
| 30 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.86866340 |
| 31 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.86291805 |
| 32 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.85432272 |
| 33 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.85149003 |
| 34 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.81277530 |
| 35 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.80285362 |
| 36 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.79026747 |
| 37 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.78282819 |
| 38 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.75186330 |
| 39 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.73434856 |
| 40 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.73341520 |
| 41 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.67854573 |
| 42 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.67173505 |
| 43 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.64331402 |
| 44 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.63913673 |
| 45 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.60973589 |
| 46 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.56940599 |
| 47 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.53955852 |
| 48 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.51497109 |
| 49 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.51285206 |
| 50 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.48995625 |
| 51 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.48014770 |
| 52 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.45925375 |
| 53 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.45213360 |
| 54 | MYC_22102868_ChIP-Seq_BL_Human | 1.44697270 |
| 55 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.44454025 |
| 56 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.44270676 |
| 57 | * YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.43048270 |
| 58 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.38054000 |
| 59 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.37055402 |
| 60 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.35249606 |
| 61 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.29470486 |
| 62 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.25662309 |
| 63 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.23079180 |
| 64 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.21273253 |
| 65 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.18703783 |
| 66 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.17303998 |
| 67 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.16224454 |
| 68 | EWS_26573619_Chip-Seq_HEK293_Human | 1.14677052 |
| 69 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.13753469 |
| 70 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.13328195 |
| 71 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.12180109 |
| 72 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.10734778 |
| 73 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.09627067 |
| 74 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.09029019 |
| 75 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.08618436 |
| 76 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.07387681 |
| 77 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.06657416 |
| 78 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.06220807 |
| 79 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.04323576 |
| 80 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.04216767 |
| 81 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.03997881 |
| 82 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.00073057 |
| 83 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.99431716 |
| 84 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.99137222 |
| 85 | FUS_26573619_Chip-Seq_HEK293_Human | 0.98036203 |
| 86 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.97883449 |
| 87 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.97369731 |
| 88 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.95922678 |
| 89 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.95546872 |
| 90 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.94206703 |
| 91 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.94173326 |
| 92 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.93974091 |
| 93 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.92488041 |
| 94 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.90915034 |
| 95 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.90235937 |
| 96 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.86832388 |
| 97 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.85657037 |
| 98 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.85121773 |
| 99 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.84522155 |
| 100 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.84450137 |
| 101 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.82220893 |
| 102 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.79855554 |
| 103 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.78850296 |
| 104 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.78300786 |
| 105 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.77897834 |
| 106 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.75840997 |
| 107 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.74614467 |
| 108 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.74529481 |
| 109 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.73967232 |
| 110 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.73371754 |
| 111 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.69746188 |
| 112 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.66670667 |
| 113 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.66036309 |
| 114 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.65696607 |
| 115 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.64393158 |
| 116 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.64345357 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.39487019 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.27734114 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.04938909 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.91527983 |
| 5 | MP0003077_abnormal_cell_cycle | 3.67323317 |
| 6 | MP0008057_abnormal_DNA_replication | 3.45440902 |
| 7 | MP0008058_abnormal_DNA_repair | 3.22914646 |
| 8 | MP0008007_abnormal_cellular_replicative | 2.91484802 |
| 9 | MP0002396_abnormal_hematopoietic_system | 2.50524597 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.38911165 |
| 11 | MP0006072_abnormal_retinal_apoptosis | 2.03645728 |
| 12 | MP0001730_embryonic_growth_arrest | 1.97768157 |
| 13 | MP0006035_abnormal_mitochondrial_morpho | 1.96049703 |
| 14 | MP0000350_abnormal_cell_proliferation | 1.92502211 |
| 15 | MP0003786_premature_aging | 1.90436768 |
| 16 | MP0003806_abnormal_nucleotide_metabolis | 1.80083368 |
| 17 | MP0010352_gastrointestinal_tract_polyps | 1.79327814 |
| 18 | MP0003718_maternal_effect | 1.73998901 |
| 19 | MP0003763_abnormal_thymus_physiology | 1.73959646 |
| 20 | MP0000490_abnormal_crypts_of | 1.72429813 |
| 21 | MP0009333_abnormal_splenocyte_physiolog | 1.67478768 |
| 22 | MP0010307_abnormal_tumor_latency | 1.67389043 |
| 23 | MP0000372_irregular_coat_pigmentation | 1.66371581 |
| 24 | MP0002163_abnormal_gland_morphology | 1.59360765 |
| 25 | MP0005084_abnormal_gallbladder_morpholo | 1.54798685 |
| 26 | MP0003123_paternal_imprinting | 1.54147295 |
| 27 | MP0004808_abnormal_hematopoietic_stem | 1.51416039 |
| 28 | MP0005397_hematopoietic_system_phenotyp | 1.51262832 |
| 29 | MP0001545_abnormal_hematopoietic_system | 1.51262832 |
| 30 | MP0001529_abnormal_vocalization | 1.48966398 |
| 31 | MP0001697_abnormal_embryo_size | 1.46660352 |
| 32 | MP0002019_abnormal_tumor_incidence | 1.44407302 |
| 33 | MP0001672_abnormal_embryogenesis/_devel | 1.44273235 |
| 34 | MP0005380_embryogenesis_phenotype | 1.44273235 |
| 35 | MP0006292_abnormal_olfactory_placode | 1.39028128 |
| 36 | MP0000313_abnormal_cell_death | 1.38851324 |
| 37 | MP0002398_abnormal_bone_marrow | 1.37876213 |
| 38 | MP0003186_abnormal_redox_activity | 1.37069845 |
| 39 | MP0002080_prenatal_lethality | 1.36595001 |
| 40 | MP0008877_abnormal_DNA_methylation | 1.35583796 |
| 41 | MP0008995_early_reproductive_senescence | 1.31039164 |
| 42 | MP0001835_abnormal_antigen_presentation | 1.29690471 |
| 43 | MP0003984_embryonic_growth_retardation | 1.29619596 |
| 44 | MP0000703_abnormal_thymus_morphology | 1.28338109 |
| 45 | MP0002722_abnormal_immune_system | 1.27335721 |
| 46 | MP0000689_abnormal_spleen_morphology | 1.27019581 |
| 47 | MP0002234_abnormal_pharynx_morphology | 1.26041032 |
| 48 | MP0002088_abnormal_embryonic_growth/wei | 1.25762151 |
| 49 | MP0005671_abnormal_response_to | 1.23031990 |
| 50 | MP0001853_heart_inflammation | 1.20218962 |
| 51 | MP0002086_abnormal_extraembryonic_tissu | 1.16023929 |
| 52 | MP0002085_abnormal_embryonic_tissue | 1.15657547 |
| 53 | MP0001293_anophthalmia | 1.15465665 |
| 54 | MP0002102_abnormal_ear_morphology | 1.12368304 |
| 55 | MP0002429_abnormal_blood_cell | 1.10335028 |
| 56 | MP0002132_abnormal_respiratory_system | 1.08787616 |
| 57 | MP0002084_abnormal_developmental_patter | 1.07139971 |
| 58 | MP0003941_abnormal_skin_development | 1.06688734 |
| 59 | MP0001800_abnormal_humoral_immune | 1.06673322 |
| 60 | MP0001727_abnormal_embryo_implantation | 1.05845643 |
| 61 | MP0003567_abnormal_fetal_cardiomyocyte | 1.03990818 |
| 62 | MP0000858_altered_metastatic_potential | 1.03889861 |
| 63 | MP0000716_abnormal_immune_system | 1.03703127 |
| 64 | MP0003937_abnormal_limbs/digits/tail_de | 1.02778705 |
| 65 | MP0003890_abnormal_embryonic-extraembry | 1.00781722 |
| 66 | MP0000685_abnormal_immune_system | 1.00222644 |
| 67 | MP0002210_abnormal_sex_determination | 0.99702961 |
| 68 | MP0004197_abnormal_fetal_growth/weight/ | 0.99085405 |
| 69 | MP0009785_altered_susceptibility_to | 0.96276970 |
| 70 | MP0002166_altered_tumor_susceptibility | 0.95412331 |
| 71 | MP0009379_abnormal_foot_pigmentation | 0.95312240 |
| 72 | MP0003011_delayed_dark_adaptation | 0.93807866 |
| 73 | MP0005075_abnormal_melanosome_morpholog | 0.93124912 |
| 74 | MP0002420_abnormal_adaptive_immunity | 0.91781940 |
| 75 | MP0002452_abnormal_antigen_presenting | 0.91186237 |
| 76 | MP0001819_abnormal_immune_cell | 0.90612615 |
| 77 | MP0000358_abnormal_cell_content/ | 0.90287585 |
| 78 | MP0001881_abnormal_mammary_gland | 0.88943238 |
| 79 | MP0003436_decreased_susceptibility_to | 0.88678477 |
| 80 | MP0002405_respiratory_system_inflammati | 0.88647049 |
| 81 | MP0003121_genomic_imprinting | 0.87974636 |
| 82 | MP0005379_endocrine/exocrine_gland_phen | 0.87176814 |
| 83 | MP0002723_abnormal_immune_serum | 0.86344338 |
| 84 | MP0006054_spinal_hemorrhage | 0.86280041 |
| 85 | MP0001145_abnormal_male_reproductive | 0.86071110 |
| 86 | MP0005253_abnormal_eye_physiology | 0.84229492 |
| 87 | MP0008873_increased_physiological_sensi | 0.82923785 |
| 88 | MP0002006_tumorigenesis | 0.82290429 |
| 89 | MP0002095_abnormal_skin_pigmentation | 0.81642105 |
| 90 | MP0001119_abnormal_female_reproductive | 0.81359217 |
| 91 | MP0005076_abnormal_cell_differentiation | 0.80982728 |
| 92 | MP0006036_abnormal_mitochondrial_physio | 0.79013749 |
| 93 | MP0004147_increased_porphyrin_level | 0.77982748 |
| 94 | MP0002938_white_spotting | 0.77813997 |
| 95 | MP0005389_reproductive_system_phenotype | 0.77710480 |
| 96 | MP0001286_abnormal_eye_development | 0.77498919 |
| 97 | MP0002837_dystrophic_cardiac_calcinosis | 0.77361300 |
| 98 | MP0001188_hyperpigmentation | 0.76393413 |
| 99 | MP0005025_abnormal_response_to | 0.76371515 |
| 100 | MP0008789_abnormal_olfactory_epithelium | 0.76321437 |
| 101 | MP0000653_abnormal_sex_gland | 0.75880034 |
| 102 | MP0010155_abnormal_intestine_physiology | 0.75212368 |
| 103 | MP0002160_abnormal_reproductive_system | 0.74814713 |
| 104 | MP0001919_abnormal_reproductive_system | 0.74809053 |
| 105 | MP0005000_abnormal_immune_tolerance | 0.74139921 |
| 106 | MP0004215_abnormal_myocardial_fiber | 0.73636177 |
| 107 | MP0005408_hypopigmentation | 0.72470005 |
| 108 | MP0002277_abnormal_respiratory_mucosa | 0.72126852 |
| 109 | MP0001929_abnormal_gametogenesis | 0.71703727 |
| 110 | MP0005023_abnormal_wound_healing | 0.71687174 |
| 111 | MP0009697_abnormal_copulation | 0.70285632 |
| 112 | MP0005384_cellular_phenotype | 0.69806741 |
| 113 | MP0000465_gastrointestinal_hemorrhage | 0.68551807 |
| 114 | MP0003315_abnormal_perineum_morphology | 0.67606286 |
| 115 | MP0001915_intracranial_hemorrhage | 0.67335563 |
| 116 | MP0005501_abnormal_skin_physiology | 0.66559541 |
| 117 | MP0005367_renal/urinary_system_phenotyp | 0.65659305 |
| 118 | MP0000516_abnormal_urinary_system | 0.65659305 |
| 119 | MP0005174_abnormal_tail_pigmentation | 0.65377888 |
| 120 | MP0001764_abnormal_homeostasis | 0.65375942 |
| 121 | MP0003698_abnormal_male_reproductive | 0.65172101 |
| 122 | MP0005266_abnormal_metabolism | 0.65038906 |
| 123 | MP0005621_abnormal_cell_physiology | 0.64996835 |
| 124 | MP0005395_other_phenotype | 0.62312993 |
| 125 | MP0003221_abnormal_cardiomyocyte_apopto | 0.61523908 |
| 126 | MP0002148_abnormal_hypersensitivity_rea | 0.61105199 |
| 127 | MP0005330_cardiomyopathy | 0.61001095 |
| 128 | MP0002111_abnormal_tail_morphology | 0.60791417 |
| 129 | MP0000598_abnormal_liver_morphology | 0.60319683 |
| 130 | MP0001873_stomach_inflammation | 0.60237531 |
| 131 | MP0000477_abnormal_intestine_morphology | 0.59822510 |
| 132 | MP0001845_abnormal_inflammatory_respons | 0.59102192 |
| 133 | MP0009053_abnormal_anal_canal | 0.58973082 |
| 134 | MP0005391_vision/eye_phenotype | 0.58803065 |
| 135 | MP0002090_abnormal_vision | 0.58211002 |
| 136 | MP0000627_abnormal_mammary_gland | 0.56276016 |
| 137 | MP0002638_abnormal_pupillary_reflex | 0.55643211 |
| 138 | MP0000631_abnormal_neuroendocrine_gland | 0.55377310 |
| 139 | MP0009250_abnormal_appendicular_skeleto | 0.54780935 |
| 140 | MP0000647_abnormal_sebaceous_gland | 0.54098053 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 4.95024845 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.84908518 |
| 3 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.84815445 |
| 4 | Abnormal number of erythroid precursors (HP:0012131) | 4.73438390 |
| 5 | Reticulocytopenia (HP:0001896) | 4.70708444 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.47763284 |
| 7 | Increased hepatocellular lipid droplets (HP:0006565) | 4.37978016 |
| 8 | Increased CSF lactate (HP:0002490) | 4.26918657 |
| 9 | Mitochondrial inheritance (HP:0001427) | 4.26103396 |
| 10 | Acute encephalopathy (HP:0006846) | 4.23248516 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 4.04378478 |
| 12 | Progressive macrocephaly (HP:0004481) | 3.97160830 |
| 13 | Hepatocellular necrosis (HP:0001404) | 3.94542116 |
| 14 | Aplastic anemia (HP:0001915) | 3.92103757 |
| 15 | Breast hypoplasia (HP:0003187) | 3.77632322 |
| 16 | Hepatic necrosis (HP:0002605) | 3.73157020 |
| 17 | Oral leukoplakia (HP:0002745) | 3.70727465 |
| 18 | 3-Methylglutaconic aciduria (HP:0003535) | 3.59247603 |
| 19 | Cerebral edema (HP:0002181) | 3.41650001 |
| 20 | Macrocytic anemia (HP:0001972) | 3.32774219 |
| 21 | Chromsome breakage (HP:0040012) | 3.31247656 |
| 22 | Pallor (HP:0000980) | 3.26139675 |
| 23 | Abnormality of the anterior horn cell (HP:0006802) | 3.23108232 |
| 24 | Degeneration of anterior horn cells (HP:0002398) | 3.23108232 |
| 25 | Increased intramyocellular lipid droplets (HP:0012240) | 3.18934326 |
| 26 | Carpal bone hypoplasia (HP:0001498) | 3.15084885 |
| 27 | Renal Fanconi syndrome (HP:0001994) | 3.01496391 |
| 28 | Patellar aplasia (HP:0006443) | 3.01393877 |
| 29 | Rough bone trabeculation (HP:0100670) | 2.99614026 |
| 30 | Lactic acidosis (HP:0003128) | 2.97053525 |
| 31 | Microretrognathia (HP:0000308) | 2.93327994 |
| 32 | Selective tooth agenesis (HP:0001592) | 2.92730662 |
| 33 | Colon cancer (HP:0003003) | 2.88723907 |
| 34 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.88427295 |
| 35 | Abnormality of chromosome stability (HP:0003220) | 2.86990770 |
| 36 | Thrombocytosis (HP:0001894) | 2.83299790 |
| 37 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.81688745 |
| 38 | Abnormality of the preputium (HP:0100587) | 2.79788807 |
| 39 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.79374350 |
| 40 | Increased serum pyruvate (HP:0003542) | 2.72195814 |
| 41 | Exercise intolerance (HP:0003546) | 2.71678502 |
| 42 | Myelodysplasia (HP:0002863) | 2.70958097 |
| 43 | Meckel diverticulum (HP:0002245) | 2.69996985 |
| 44 | Exertional dyspnea (HP:0002875) | 2.68720190 |
| 45 | Increased muscle lipid content (HP:0009058) | 2.62072671 |
| 46 | Respiratory difficulties (HP:0002880) | 2.61916476 |
| 47 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.61791555 |
| 48 | Premature ovarian failure (HP:0008209) | 2.60106037 |
| 49 | IgM deficiency (HP:0002850) | 2.58583961 |
| 50 | Abnormality of the ileum (HP:0001549) | 2.57076117 |
| 51 | Absent thumb (HP:0009777) | 2.52891406 |
| 52 | Medulloblastoma (HP:0002885) | 2.50999490 |
| 53 | Respiratory failure (HP:0002878) | 2.50171267 |
| 54 | Premature graying of hair (HP:0002216) | 2.50089148 |
| 55 | Leukodystrophy (HP:0002415) | 2.46723666 |
| 56 | Bone marrow hypocellularity (HP:0005528) | 2.42655784 |
| 57 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.41233384 |
| 58 | Congenital, generalized hypertrichosis (HP:0004540) | 2.40662043 |
| 59 | Abnormality of methionine metabolism (HP:0010901) | 2.39646036 |
| 60 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.33155410 |
| 61 | Abnormality of alanine metabolism (HP:0010916) | 2.33155410 |
| 62 | Hyperalaninemia (HP:0003348) | 2.33155410 |
| 63 | Cellular immunodeficiency (HP:0005374) | 2.32558015 |
| 64 | Volvulus (HP:0002580) | 2.29247408 |
| 65 | Abnormality of glycolysis (HP:0004366) | 2.28596317 |
| 66 | Agnosia (HP:0010524) | 2.28513025 |
| 67 | Impulsivity (HP:0100710) | 2.26278237 |
| 68 | Absent radius (HP:0003974) | 2.25835278 |
| 69 | Type I transferrin isoform profile (HP:0003642) | 2.25480654 |
| 70 | Trismus (HP:0000211) | 2.24089481 |
| 71 | Cerebral hypomyelination (HP:0006808) | 2.23987781 |
| 72 | Multiple enchondromatosis (HP:0005701) | 2.23460076 |
| 73 | Neoplasm of the pancreas (HP:0002894) | 2.22942808 |
| 74 | Pancytopenia (HP:0001876) | 2.20870551 |
| 75 | Lymphoma (HP:0002665) | 2.20754149 |
| 76 | Small intestinal stenosis (HP:0012848) | 2.19418182 |
| 77 | Duodenal stenosis (HP:0100867) | 2.19418182 |
| 78 | Amaurosis fugax (HP:0100576) | 2.18550867 |
| 79 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.17504201 |
| 80 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.17504201 |
| 81 | Abnormal trabecular bone morphology (HP:0100671) | 2.17446308 |
| 82 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.14057185 |
| 83 | Methylmalonic acidemia (HP:0002912) | 2.13946237 |
| 84 | Abnormality of placental membranes (HP:0011409) | 2.13536151 |
| 85 | Amniotic constriction ring (HP:0009775) | 2.13536151 |
| 86 | Lethargy (HP:0001254) | 2.08129632 |
| 87 | 11 pairs of ribs (HP:0000878) | 2.07931384 |
| 88 | Abnormal protein glycosylation (HP:0012346) | 2.07881353 |
| 89 | Abnormal glycosylation (HP:0012345) | 2.07881353 |
| 90 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.07881353 |
| 91 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.07881353 |
| 92 | Cleft eyelid (HP:0000625) | 2.07638175 |
| 93 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.07396399 |
| 94 | Optic disc pallor (HP:0000543) | 2.06626082 |
| 95 | B lymphocytopenia (HP:0010976) | 2.04743431 |
| 96 | Supernumerary spleens (HP:0009799) | 2.04038521 |
| 97 | Absent forearm bone (HP:0003953) | 2.03634994 |
| 98 | Aplasia involving forearm bones (HP:0009822) | 2.03634994 |
| 99 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.03553410 |
| 100 | Abnormal number of incisors (HP:0011064) | 2.03331366 |
| 101 | Rhabdomyosarcoma (HP:0002859) | 2.02912664 |
| 102 | Generalized aminoaciduria (HP:0002909) | 2.02844373 |
| 103 | Short middle phalanx of the 5th finger (HP:0004220) | 2.02593094 |
| 104 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.02168824 |
| 105 | Sloping forehead (HP:0000340) | 2.02011302 |
| 106 | Secondary amenorrhea (HP:0000869) | 1.99655676 |
| 107 | Muscle fiber atrophy (HP:0100295) | 1.97275084 |
| 108 | Atresia of the external auditory canal (HP:0000413) | 1.94822753 |
| 109 | Petechiae (HP:0000967) | 1.94298096 |
| 110 | Abnormality of reticulocytes (HP:0004312) | 1.91639358 |
| 111 | Triphalangeal thumb (HP:0001199) | 1.91459063 |
| 112 | Optic nerve coloboma (HP:0000588) | 1.91190607 |
| 113 | CNS demyelination (HP:0007305) | 1.91160199 |
| 114 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.90929230 |
| 115 | IgG deficiency (HP:0004315) | 1.89283334 |
| 116 | Microvesicular hepatic steatosis (HP:0001414) | 1.88889995 |
| 117 | Abnormality of the duodenum (HP:0002246) | 1.88168548 |
| 118 | Horseshoe kidney (HP:0000085) | 1.87564251 |
| 119 | Abnormality of serum amino acid levels (HP:0003112) | 1.85777615 |
| 120 | Abnormality of renal resorption (HP:0011038) | 1.85519101 |
| 121 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.85085311 |
| 122 | Abnormality of urine glucose concentration (HP:0011016) | 1.84960170 |
| 123 | Glycosuria (HP:0003076) | 1.84960170 |
| 124 | Methylmalonic aciduria (HP:0012120) | 1.84504941 |
| 125 | Stenosis of the external auditory canal (HP:0000402) | 1.83544027 |
| 126 | Increased serum lactate (HP:0002151) | 1.82857375 |
| 127 | Type 2 muscle fiber atrophy (HP:0003554) | 1.82732669 |
| 128 | Granulocytopenia (HP:0001913) | 1.82307771 |
| 129 | Sparse eyelashes (HP:0000653) | 1.81983511 |
| 130 | Abnormal lung lobation (HP:0002101) | 1.81545883 |
| 131 | Abnormality of T cells (HP:0002843) | 1.79819088 |
| 132 | Combined immunodeficiency (HP:0005387) | 1.79289044 |
| 133 | Abnormality of the labia minora (HP:0012880) | 1.78377356 |
| 134 | Reduced antithrombin III activity (HP:0001976) | 1.78248731 |
| 135 | Facial hemangioma (HP:0000329) | 1.77633021 |
| 136 | Severe combined immunodeficiency (HP:0004430) | 1.77373445 |
| 137 | Abnormal spermatogenesis (HP:0008669) | 1.76966877 |
| 138 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 1.76831296 |
| 139 | Entropion (HP:0000621) | 1.76798066 |
| 140 | Progressive muscle weakness (HP:0003323) | 1.75174872 |
| 141 | Megaloblastic anemia (HP:0001889) | 1.74770991 |
| 142 | Clubbing of toes (HP:0100760) | 1.74547711 |
| 143 | X-linked dominant inheritance (HP:0001423) | 1.74467195 |
| 144 | Tracheoesophageal fistula (HP:0002575) | 1.74316398 |
| 145 | Pancreatic cysts (HP:0001737) | 1.73774732 |
| 146 | Abnormality of T cell physiology (HP:0011840) | 1.72335212 |
| 147 | Abnormality of the pons (HP:0007361) | 1.72329783 |
| 148 | Acute myeloid leukemia (HP:0004808) | 1.72298738 |
| 149 | Proximal placement of thumb (HP:0009623) | 1.72251282 |
| 150 | Basal cell carcinoma (HP:0002671) | 1.72045667 |
| 151 | Renal cortical cysts (HP:0000803) | 1.71850393 |
| 152 | Prominent nose (HP:0000448) | 1.71575596 |
| 153 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.70582601 |
| 154 | Ependymoma (HP:0002888) | 1.69267519 |
| 155 | Hypoplasia of the radius (HP:0002984) | 1.67419492 |
| 156 | Leukopenia (HP:0001882) | 1.65256424 |
| 157 | Poikiloderma (HP:0001029) | 1.63987908 |
| 158 | Slender long bone (HP:0003100) | 1.63959939 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.30950017 |
| 2 | WEE1 | 4.10040411 |
| 3 | CDC7 | 3.32759302 |
| 4 | EIF2AK1 | 3.32572328 |
| 5 | VRK2 | 2.91797077 |
| 6 | NME2 | 2.72275430 |
| 7 | STK16 | 2.69647537 |
| 8 | SRPK1 | 2.64233233 |
| 9 | ACVR1B | 2.58730334 |
| 10 | TRIM28 | 2.46676571 |
| 11 | NEK2 | 2.37550835 |
| 12 | EIF2AK3 | 2.33775499 |
| 13 | BRSK2 | 2.31101862 |
| 14 | PLK4 | 2.27609154 |
| 15 | NUAK1 | 2.20974202 |
| 16 | DYRK3 | 1.97333888 |
| 17 | VRK1 | 1.92338111 |
| 18 | RPS6KA4 | 1.90992231 |
| 19 | RPS6KB2 | 1.88228816 |
| 20 | MAP3K12 | 1.87482814 |
| 21 | TLK1 | 1.86998244 |
| 22 | TSSK6 | 1.82895135 |
| 23 | TTK | 1.76813650 |
| 24 | TESK2 | 1.75156561 |
| 25 | PLK1 | 1.70957613 |
| 26 | MKNK1 | 1.63153572 |
| 27 | CDK7 | 1.60858852 |
| 28 | AURKB | 1.59554767 |
| 29 | PDK2 | 1.57455812 |
| 30 | PNCK | 1.56079219 |
| 31 | STK10 | 1.50640297 |
| 32 | ATR | 1.48196408 |
| 33 | NEK1 | 1.47871038 |
| 34 | PIM2 | 1.47258714 |
| 35 | ZAK | 1.37965694 |
| 36 | KDR | 1.31263200 |
| 37 | MKNK2 | 1.29739345 |
| 38 | EPHA2 | 1.29330535 |
| 39 | PASK | 1.27453418 |
| 40 | TGFBR1 | 1.24941405 |
| 41 | PLK3 | 1.21113709 |
| 42 | MAP3K8 | 1.18698747 |
| 43 | BMPR1B | 1.14378659 |
| 44 | MAP4K1 | 1.12801922 |
| 45 | CDK4 | 1.12628959 |
| 46 | CHEK2 | 1.11048392 |
| 47 | STK4 | 1.09243106 |
| 48 | WNK3 | 1.08850326 |
| 49 | PIM1 | 1.08200784 |
| 50 | ERBB3 | 1.07602093 |
| 51 | SCYL2 | 1.07572011 |
| 52 | CDK12 | 1.04914203 |
| 53 | AURKA | 1.04337332 |
| 54 | BRSK1 | 1.03523040 |
| 55 | TAF1 | 1.03305305 |
| 56 | BCR | 1.01904600 |
| 57 | FLT3 | 0.94671511 |
| 58 | IRAK3 | 0.94161415 |
| 59 | EIF2AK2 | 0.91102328 |
| 60 | MAP4K2 | 0.90916646 |
| 61 | CHEK1 | 0.90217272 |
| 62 | CCNB1 | 0.89313111 |
| 63 | PAK4 | 0.87364894 |
| 64 | TEC | 0.82335926 |
| 65 | PBK | 0.81993719 |
| 66 | RPS6KA5 | 0.81830490 |
| 67 | TXK | 0.80440188 |
| 68 | MAPKAPK3 | 0.79409286 |
| 69 | EEF2K | 0.76016306 |
| 70 | LRRK2 | 0.73988671 |
| 71 | ATM | 0.72518898 |
| 72 | BTK | 0.71286646 |
| 73 | ZAP70 | 0.71124751 |
| 74 | CDK3 | 0.68347023 |
| 75 | NEK9 | 0.68175448 |
| 76 | CSNK2A2 | 0.67100816 |
| 77 | CSNK2A1 | 0.65029418 |
| 78 | TYK2 | 0.64344262 |
| 79 | CDK8 | 0.64044529 |
| 80 | CDK2 | 0.64007145 |
| 81 | TESK1 | 0.61195902 |
| 82 | MST4 | 0.60374876 |
| 83 | CLK1 | 0.60344062 |
| 84 | MAP3K10 | 0.59661773 |
| 85 | CDK6 | 0.59146301 |
| 86 | IRAK4 | 0.57917270 |
| 87 | BLK | 0.57694723 |
| 88 | MELK | 0.55112550 |
| 89 | BRAF | 0.54968862 |
| 90 | MAP2K3 | 0.53826292 |
| 91 | BCKDK | 0.53279777 |
| 92 | SIK3 | 0.52788024 |
| 93 | PLK2 | 0.52768426 |
| 94 | IKBKB | 0.52190614 |
| 95 | CSNK1G1 | 0.50987381 |
| 96 | JAK3 | 0.50806237 |
| 97 | KIT | 0.48905866 |
| 98 | CSNK1E | 0.46835685 |
| 99 | PAK1 | 0.45826217 |
| 100 | DAPK1 | 0.43927529 |
| 101 | CDK9 | 0.43773839 |
| 102 | TNIK | 0.43615610 |
| 103 | CDK19 | 0.43291257 |
| 104 | CDK1 | 0.42645423 |
| 105 | CSNK1G3 | 0.39808564 |
| 106 | NLK | 0.39418377 |
| 107 | BRD4 | 0.39104265 |
| 108 | CHUK | 0.37665427 |
| 109 | STK3 | 0.36240384 |
| 110 | PRKCI | 0.35471268 |
| 111 | GRK1 | 0.35349375 |
| 112 | STK39 | 0.34441120 |
| 113 | DYRK2 | 0.33362484 |
| 114 | MAP3K4 | 0.32567881 |
| 115 | AKT3 | 0.31463191 |
| 116 | LYN | 0.31289213 |
| 117 | ADRBK2 | 0.31134706 |
| 118 | MAP3K3 | 0.30797566 |
| 119 | NME1 | 0.30586656 |
| 120 | ITK | 0.30539970 |
| 121 | MAP3K11 | 0.30109907 |
| 122 | ILK | 0.27793520 |
| 123 | STK38L | 0.27755220 |
| 124 | ERBB4 | 0.27321457 |
| 125 | ABL2 | 0.27200869 |
| 126 | ALK | 0.25099796 |
| 127 | MARK3 | 0.24597890 |
| 128 | FGFR1 | 0.24401654 |
| 129 | TGFBR2 | 0.23913561 |
| 130 | MYLK | 0.22787332 |
| 131 | YES1 | 0.22246678 |
| 132 | MAP3K5 | 0.22112976 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.43296240 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 3.94459081 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.74413570 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.61390779 |
| 5 | Proteasome_Homo sapiens_hsa03050 | 3.30098118 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.29996762 |
| 7 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.27322848 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 3.22227155 |
| 9 | RNA transport_Homo sapiens_hsa03013 | 2.88444870 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.74173705 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.65810685 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.63154450 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.57771238 |
| 14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.50674646 |
| 15 | Cell cycle_Homo sapiens_hsa04110 | 2.36321966 |
| 16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.22217989 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.95583852 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.88787316 |
| 19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.88271201 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.85140143 |
| 21 | Alzheimers disease_Homo sapiens_hsa05010 | 1.75664415 |
| 22 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.58572811 |
| 23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.49277314 |
| 24 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.42718195 |
| 25 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.41865780 |
| 26 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.39073451 |
| 27 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.38476617 |
| 28 | Protein export_Homo sapiens_hsa03060 | 1.33775892 |
| 29 | Purine metabolism_Homo sapiens_hsa00230 | 1.30705508 |
| 30 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.21781011 |
| 31 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.21634307 |
| 32 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.18047271 |
| 33 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.15568415 |
| 34 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.15391349 |
| 35 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.10427495 |
| 36 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.06466663 |
| 37 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.99013438 |
| 38 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.98147103 |
| 39 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.96400622 |
| 40 | Sulfur relay system_Homo sapiens_hsa04122 | 0.94769447 |
| 41 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.94639436 |
| 42 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.92897809 |
| 43 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.92538171 |
| 44 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.90133151 |
| 45 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.86193640 |
| 46 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.85136067 |
| 47 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.84373286 |
| 48 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.82767136 |
| 49 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.80235520 |
| 50 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.79918390 |
| 51 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.72741133 |
| 52 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.71941090 |
| 53 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.71342965 |
| 54 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.71213821 |
| 55 | Legionellosis_Homo sapiens_hsa05134 | 0.70905062 |
| 56 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.64593534 |
| 57 | Measles_Homo sapiens_hsa05162 | 0.64481478 |
| 58 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.64433309 |
| 59 | HTLV-I infection_Homo sapiens_hsa05166 | 0.64188508 |
| 60 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.57526667 |
| 61 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.56050106 |
| 62 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.55105063 |
| 63 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.53196804 |
| 64 | Apoptosis_Homo sapiens_hsa04210 | 0.51024015 |
| 65 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.51017137 |
| 66 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.50318657 |
| 67 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.48626747 |
| 68 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.48561380 |
| 69 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.48451942 |
| 70 | Allograft rejection_Homo sapiens_hsa05330 | 0.47585183 |
| 71 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.46578551 |
| 72 | Huntingtons disease_Homo sapiens_hsa05016 | 0.46059688 |
| 73 | Thyroid cancer_Homo sapiens_hsa05216 | 0.44546886 |
| 74 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.43579261 |
| 75 | Carbon metabolism_Homo sapiens_hsa01200 | 0.42139426 |
| 76 | Peroxisome_Homo sapiens_hsa04146 | 0.41302349 |
| 77 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.39279521 |
| 78 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.39159554 |
| 79 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.38694761 |
| 80 | Influenza A_Homo sapiens_hsa05164 | 0.36399519 |
| 81 | Hepatitis B_Homo sapiens_hsa05161 | 0.36159921 |
| 82 | Asthma_Homo sapiens_hsa05310 | 0.36000458 |
| 83 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.35052045 |
| 84 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.34890329 |
| 85 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.32348438 |
| 86 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.31423467 |
| 87 | Shigellosis_Homo sapiens_hsa05131 | 0.30646569 |
| 88 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.30012177 |
| 89 | Parkinsons disease_Homo sapiens_hsa05012 | 0.29836367 |
| 90 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.28921070 |
| 91 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.28874167 |
| 92 | Metabolic pathways_Homo sapiens_hsa01100 | 0.28724105 |
| 93 | Alcoholism_Homo sapiens_hsa05034 | 0.28661323 |
| 94 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.28600602 |
| 95 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.27614598 |
| 96 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.25631592 |
| 97 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.25550180 |
| 98 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.25304726 |
| 99 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.25007517 |
| 100 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.23844961 |
| 101 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.23672494 |
| 102 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.23161520 |
| 103 | Leishmaniasis_Homo sapiens_hsa05140 | 0.22871202 |
| 104 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.22571749 |
| 105 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.22113888 |
| 106 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.21496245 |
| 107 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.21491343 |
| 108 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.21212432 |
| 109 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.20803356 |
| 110 | Galactose metabolism_Homo sapiens_hsa00052 | 0.18658920 |
| 111 | Colorectal cancer_Homo sapiens_hsa05210 | 0.18426928 |
| 112 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.17073113 |
| 113 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.16983768 |
| 114 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.16948804 |
| 115 | Viral myocarditis_Homo sapiens_hsa05416 | 0.15424038 |
| 116 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.15414318 |
| 117 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.15121069 |
| 118 | Other glycan degradation_Homo sapiens_hsa00511 | 0.14646664 |
| 119 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.13898599 |
| 120 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.13571845 |
| 121 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.13539803 |
| 122 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.13241341 |
| 123 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.12751718 |
| 124 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.12715790 |
| 125 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.11439148 |
| 126 | Retinol metabolism_Homo sapiens_hsa00830 | 0.07890663 |
| 127 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.07622025 |
| 128 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.05718239 |
| 129 | Phototransduction_Homo sapiens_hsa04744 | 0.05457139 |

