

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | maturation of SSU-rRNA (GO:0030490) | 4.89522819 |
| 2 | ribosomal small subunit assembly (GO:0000028) | 4.73289888 |
| 3 | ribosomal small subunit biogenesis (GO:0042274) | 4.67294173 |
| 4 | proteasome assembly (GO:0043248) | 4.60726795 |
| 5 | chaperone-mediated protein transport (GO:0072321) | 4.53490433 |
| 6 | ribosomal large subunit biogenesis (GO:0042273) | 4.47441052 |
| 7 | nucleobase biosynthetic process (GO:0046112) | 4.43927325 |
| 8 | formation of translation preinitiation complex (GO:0001731) | 4.39965764 |
| 9 | purine nucleobase biosynthetic process (GO:0009113) | 4.37396571 |
| 10 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.33735797 |
| 11 | viral transcription (GO:0019083) | 4.29616989 |
| 12 | translational termination (GO:0006415) | 4.27090333 |
| 13 | CENP-A containing nucleosome assembly (GO:0034080) | 4.26659861 |
| 14 | ribosome biogenesis (GO:0042254) | 4.18972592 |
| 15 | termination of RNA polymerase III transcription (GO:0006386) | 4.15003763 |
| 16 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.15003763 |
| 17 | DNA replication checkpoint (GO:0000076) | 4.14565601 |
| 18 | chromatin remodeling at centromere (GO:0031055) | 4.13752360 |
| 19 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.08867143 |
| 20 | ribosome assembly (GO:0042255) | 4.08085031 |
| 21 | mitotic metaphase plate congression (GO:0007080) | 4.05068849 |
| 22 | spliceosomal snRNP assembly (GO:0000387) | 4.05068286 |
| 23 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.01657944 |
| 24 | DNA replication initiation (GO:0006270) | 4.01397796 |
| 25 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.99941835 |
| 26 | rRNA processing (GO:0006364) | 3.96262273 |
| 27 | 7-methylguanosine mRNA capping (GO:0006370) | 3.94400919 |
| 28 | 7-methylguanosine RNA capping (GO:0009452) | 3.91565224 |
| 29 | RNA capping (GO:0036260) | 3.91565224 |
| 30 | rRNA modification (GO:0000154) | 3.91292113 |
| 31 | translational initiation (GO:0006413) | 3.90061832 |
| 32 | cullin deneddylation (GO:0010388) | 3.88642305 |
| 33 | DNA strand elongation (GO:0022616) | 3.88073797 |
| 34 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.87277179 |
| 35 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.87026395 |
| 36 | regulation of mitochondrial translation (GO:0070129) | 3.86660159 |
| 37 | pseudouridine synthesis (GO:0001522) | 3.85121289 |
| 38 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.85066939 |
| 39 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.84381215 |
| 40 | rRNA metabolic process (GO:0016072) | 3.82842152 |
| 41 | translational elongation (GO:0006414) | 3.82006350 |
| 42 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.80594138 |
| 43 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.80010668 |
| 44 | termination of RNA polymerase I transcription (GO:0006363) | 3.78344695 |
| 45 | cotranslational protein targeting to membrane (GO:0006613) | 3.76821322 |
| 46 | protein targeting to ER (GO:0045047) | 3.71807909 |
| 47 | DNA deamination (GO:0045006) | 3.70742119 |
| 48 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.68394350 |
| 49 | DNA replication-independent nucleosome organization (GO:0034724) | 3.68394350 |
| 50 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.68109820 |
| 51 | negative regulation of ligase activity (GO:0051352) | 3.68109820 |
| 52 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.66088344 |
| 53 | telomere maintenance via recombination (GO:0000722) | 3.64460450 |
| 54 | kinetochore organization (GO:0051383) | 3.64297545 |
| 55 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.64276028 |
| 56 | protein deneddylation (GO:0000338) | 3.62442914 |
| 57 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.60146776 |
| 58 | DNA damage response, detection of DNA damage (GO:0042769) | 3.58974577 |
| 59 | establishment of integrated proviral latency (GO:0075713) | 3.57898520 |
| 60 | cellular component biogenesis (GO:0044085) | 3.57703777 |
| 61 | spliceosomal complex assembly (GO:0000245) | 3.56761828 |
| 62 | kinetochore assembly (GO:0051382) | 3.56188101 |
| 63 | protein localization to endoplasmic reticulum (GO:0070972) | 3.54945290 |
| 64 | translation (GO:0006412) | 3.54297749 |
| 65 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.53520256 |
| 66 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.53303105 |
| 67 | transcription from RNA polymerase I promoter (GO:0006360) | 3.52964595 |
| 68 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.50457866 |
| 69 | histone exchange (GO:0043486) | 3.48537447 |
| 70 | cellular protein complex disassembly (GO:0043624) | 3.48276838 |
| 71 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.48098935 |
| 72 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.47492912 |
| 73 | protein targeting to mitochondrion (GO:0006626) | 3.44404944 |
| 74 | protein complex biogenesis (GO:0070271) | 3.44230761 |
| 75 | mitotic recombination (GO:0006312) | 3.44203881 |
| 76 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.43679665 |
| 77 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.43679665 |
| 78 | metaphase plate congression (GO:0051310) | 3.43106831 |
| 79 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.41886683 |
| 80 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.41886683 |
| 81 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.41886683 |
| 82 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.41000772 |
| 83 | respiratory electron transport chain (GO:0022904) | 3.39488589 |
| 84 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.37900743 |
| 85 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.37900743 |
| 86 | DNA double-strand break processing (GO:0000729) | 3.37088048 |
| 87 | viral life cycle (GO:0019058) | 3.34540932 |
| 88 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.34479477 |
| 89 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.34479477 |
| 90 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.33861127 |
| 91 | respiratory chain complex IV assembly (GO:0008535) | 3.33109460 |
| 92 | IMP biosynthetic process (GO:0006188) | 3.32501424 |
| 93 | electron transport chain (GO:0022900) | 3.32127538 |
| 94 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.31916744 |
| 95 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.31916744 |
| 96 | NADH dehydrogenase complex assembly (GO:0010257) | 3.31916744 |
| 97 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.31504375 |
| 98 | cell cycle G1/S phase transition (GO:0044843) | 3.31504375 |
| 99 | mitochondrial RNA metabolic process (GO:0000959) | 3.29943878 |
| 100 | telomere maintenance via telomere lengthening (GO:0010833) | 3.29457798 |
| 101 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.29384632 |
| 102 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.27046877 |
| 103 | positive regulation of ligase activity (GO:0051351) | 3.26559006 |
| 104 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.26142930 |
| 105 | ATP synthesis coupled proton transport (GO:0015986) | 3.26142930 |
| 106 | IMP metabolic process (GO:0046040) | 3.25352502 |
| 107 | maturation of 5.8S rRNA (GO:0000460) | 3.23983922 |
| 108 | tRNA aminoacylation (GO:0043039) | 3.23317637 |
| 109 | amino acid activation (GO:0043038) | 3.23317637 |
| 110 | protein localization to mitochondrion (GO:0070585) | 3.22877700 |
| 111 | protein neddylation (GO:0045116) | 3.22627464 |
| 112 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.21248827 |
| 113 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.20802604 |
| 114 | histone mRNA metabolic process (GO:0008334) | 3.20280709 |
| 115 | tRNA aminoacylation for protein translation (GO:0006418) | 3.20226638 |
| 116 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.19704140 |
| 117 | protein localization to kinetochore (GO:0034501) | 3.16674692 |
| 118 | transcription from mitochondrial promoter (GO:0006390) | 3.16669125 |
| 119 | establishment of protein localization to mitochondrion (GO:0072655) | 3.16115574 |
| 120 | rRNA methylation (GO:0031167) | 3.14843899 |
| 121 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.13657889 |
| 122 | mitotic nuclear envelope disassembly (GO:0007077) | 3.12640145 |
| 123 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.12522810 |
| 124 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.12522810 |
| 125 | viral mRNA export from host cell nucleus (GO:0046784) | 3.11894073 |
| 126 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.11343589 |
| 127 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.11295779 |
| 128 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.11078060 |
| 129 | establishment of chromosome localization (GO:0051303) | 3.10712151 |
| 130 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.07345033 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.72962936 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.78387249 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.41701674 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.07397089 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.02821051 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.66979865 |
| 7 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.57630811 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.53868242 |
| 9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.52594836 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.36745458 |
| 11 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.25860980 |
| 12 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.24659453 |
| 13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.17138885 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.15015864 |
| 15 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 3.08567247 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.99046316 |
| 17 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.90627732 |
| 18 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.80793655 |
| 19 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.78905981 |
| 20 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.75286454 |
| 21 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.72143807 |
| 22 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.70820360 |
| 23 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.49850750 |
| 24 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.49464843 |
| 25 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.45693205 |
| 26 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.29393824 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.27299453 |
| 28 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.27223187 |
| 29 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.25758710 |
| 30 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.25511163 |
| 31 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.24607874 |
| 32 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.19934971 |
| 33 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.08898009 |
| 34 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.02041359 |
| 35 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.01541424 |
| 36 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.94709627 |
| 37 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.91621240 |
| 38 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.90735316 |
| 39 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.90177833 |
| 40 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.89721058 |
| 41 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.87806960 |
| 42 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.86900418 |
| 43 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.84960801 |
| 44 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.84170775 |
| 45 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.80742086 |
| 46 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.70548338 |
| 47 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.65115102 |
| 48 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.64831060 |
| 49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.64747348 |
| 50 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.63556954 |
| 51 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.61732630 |
| 52 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.47185801 |
| 53 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.45102164 |
| 54 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.44506116 |
| 55 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.41098164 |
| 56 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37419910 |
| 57 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.34368792 |
| 58 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.32651523 |
| 59 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.29994311 |
| 60 | EWS_26573619_Chip-Seq_HEK293_Human | 1.29093793 |
| 61 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.28660812 |
| 62 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.28309652 |
| 63 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.27653604 |
| 64 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.27266072 |
| 65 | VDR_22108803_ChIP-Seq_LS180_Human | 1.26828851 |
| 66 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.25735341 |
| 67 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.25701090 |
| 68 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.22523725 |
| 69 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.18480781 |
| 70 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.09559286 |
| 71 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.09552916 |
| 72 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.06117845 |
| 73 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.02754637 |
| 74 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.02494227 |
| 75 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.01720545 |
| 76 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.01302600 |
| 77 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.99268503 |
| 78 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.98232803 |
| 79 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.96720775 |
| 80 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.95702555 |
| 81 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.95031852 |
| 82 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.94151317 |
| 83 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.89291093 |
| 84 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.89178562 |
| 85 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.87802352 |
| 86 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.87264340 |
| 87 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.86806684 |
| 88 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.86786134 |
| 89 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.86643264 |
| 90 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.85795648 |
| 91 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.85784002 |
| 92 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.85318954 |
| 93 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.84927078 |
| 94 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.82691852 |
| 95 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.80150146 |
| 96 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.77492456 |
| 97 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.77323842 |
| 98 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.76618273 |
| 99 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.76505539 |
| 100 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.76234455 |
| 101 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.74003622 |
| 102 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.73475128 |
| 103 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.73308507 |
| 104 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.71530674 |
| 105 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.70934292 |
| 106 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.69840244 |
| 107 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.68519239 |
| 108 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.67207640 |
| 109 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.66004102 |
| 110 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.65512309 |
| 111 | FUS_26573619_Chip-Seq_HEK293_Human | 0.64960885 |
| 112 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.64688764 |
| 113 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.64012793 |
| 114 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.63770976 |
| 115 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.62866212 |
| 116 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.61198322 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.99389404 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.88119317 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.65467504 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.28441227 |
| 5 | MP0008057_abnormal_DNA_replication | 4.23846842 |
| 6 | MP0003077_abnormal_cell_cycle | 4.03093880 |
| 7 | MP0008058_abnormal_DNA_repair | 3.99936642 |
| 8 | MP0008932_abnormal_embryonic_tissue | 3.10277825 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.76449070 |
| 10 | MP0003123_paternal_imprinting | 2.67151923 |
| 11 | MP0003786_premature_aging | 2.54236681 |
| 12 | MP0008877_abnormal_DNA_methylation | 2.47963381 |
| 13 | MP0009379_abnormal_foot_pigmentation | 2.44558617 |
| 14 | MP0003718_maternal_effect | 2.44099292 |
| 15 | MP0001730_embryonic_growth_arrest | 2.18914475 |
| 16 | MP0001529_abnormal_vocalization | 1.94678226 |
| 17 | MP0000350_abnormal_cell_proliferation | 1.93764950 |
| 18 | MP0002396_abnormal_hematopoietic_system | 1.83406723 |
| 19 | MP0003806_abnormal_nucleotide_metabolis | 1.80342419 |
| 20 | MP0006292_abnormal_olfactory_placode | 1.77239824 |
| 21 | MP0006072_abnormal_retinal_apoptosis | 1.70735771 |
| 22 | MP0003136_yellow_coat_color | 1.52961809 |
| 23 | MP0002837_dystrophic_cardiac_calcinosis | 1.52300943 |
| 24 | MP0003315_abnormal_perineum_morphology | 1.51084342 |
| 25 | MP0001697_abnormal_embryo_size | 1.45992905 |
| 26 | MP0002210_abnormal_sex_determination | 1.43670609 |
| 27 | MP0009333_abnormal_splenocyte_physiolog | 1.41391920 |
| 28 | MP0001672_abnormal_embryogenesis/_devel | 1.35609133 |
| 29 | MP0005380_embryogenesis_phenotype | 1.35609133 |
| 30 | MP0003186_abnormal_redox_activity | 1.35316680 |
| 31 | MP0002102_abnormal_ear_morphology | 1.34649991 |
| 32 | MP0002080_prenatal_lethality | 1.34417967 |
| 33 | MP0003121_genomic_imprinting | 1.32181615 |
| 34 | MP0000313_abnormal_cell_death | 1.29070750 |
| 35 | MP0006035_abnormal_mitochondrial_morpho | 1.28732723 |
| 36 | MP0003567_abnormal_fetal_cardiomyocyte | 1.25425175 |
| 37 | MP0006036_abnormal_mitochondrial_physio | 1.23445577 |
| 38 | MP0001145_abnormal_male_reproductive | 1.22473652 |
| 39 | MP0002085_abnormal_embryonic_tissue | 1.17331756 |
| 40 | MP0005084_abnormal_gallbladder_morpholo | 1.16723961 |
| 41 | MP0001929_abnormal_gametogenesis | 1.16621015 |
| 42 | MP0000490_abnormal_crypts_of | 1.15644741 |
| 43 | MP0003984_embryonic_growth_retardation | 1.13184151 |
| 44 | MP0002132_abnormal_respiratory_system | 1.12568218 |
| 45 | MP0002938_white_spotting | 1.10951185 |
| 46 | MP0009697_abnormal_copulation | 1.10639532 |
| 47 | MP0003890_abnormal_embryonic-extraembry | 1.10365545 |
| 48 | MP0001986_abnormal_taste_sensitivity | 1.09463056 |
| 49 | MP0004133_heterotaxia | 1.09455986 |
| 50 | MP0002088_abnormal_embryonic_growth/wei | 1.09059636 |
| 51 | MP0002019_abnormal_tumor_incidence | 1.06995124 |
| 52 | MP0000653_abnormal_sex_gland | 1.06365678 |
| 53 | MP0000358_abnormal_cell_content/ | 1.04702125 |
| 54 | MP0002160_abnormal_reproductive_system | 1.02476919 |
| 55 | MP0001905_abnormal_dopamine_level | 1.02221530 |
| 56 | MP0002751_abnormal_autonomic_nervous | 1.01506056 |
| 57 | MP0004215_abnormal_myocardial_fiber | 1.00935315 |
| 58 | MP0002084_abnormal_developmental_patter | 1.00679749 |
| 59 | MP0001188_hyperpigmentation | 0.98542886 |
| 60 | MP0002277_abnormal_respiratory_mucosa | 0.98159139 |
| 61 | MP0010307_abnormal_tumor_latency | 0.96893075 |
| 62 | MP0003011_delayed_dark_adaptation | 0.96647472 |
| 63 | MP0002163_abnormal_gland_morphology | 0.95815039 |
| 64 | MP0001293_anophthalmia | 0.95059179 |
| 65 | MP0005389_reproductive_system_phenotype | 0.93586148 |
| 66 | MP0002638_abnormal_pupillary_reflex | 0.92286720 |
| 67 | MP0008995_early_reproductive_senescence | 0.89622318 |
| 68 | MP0002234_abnormal_pharynx_morphology | 0.88621319 |
| 69 | MP0003221_abnormal_cardiomyocyte_apopto | 0.88306746 |
| 70 | MP0008260_abnormal_autophagy | 0.87879732 |
| 71 | MP0003195_calcinosis | 0.87668993 |
| 72 | MP0004197_abnormal_fetal_growth/weight/ | 0.87558359 |
| 73 | MP0009672_abnormal_birth_weight | 0.84770873 |
| 74 | MP0005075_abnormal_melanosome_morpholog | 0.82890196 |
| 75 | MP0001485_abnormal_pinna_reflex | 0.82006132 |
| 76 | MP0002736_abnormal_nociception_after | 0.81991707 |
| 77 | MP0002086_abnormal_extraembryonic_tissu | 0.81913985 |
| 78 | MP0000372_irregular_coat_pigmentation | 0.81192844 |
| 79 | MP0003938_abnormal_ear_development | 0.81073398 |
| 80 | MP0003763_abnormal_thymus_physiology | 0.80795642 |
| 81 | MP0000049_abnormal_middle_ear | 0.80195381 |
| 82 | MP0001764_abnormal_homeostasis | 0.76134268 |
| 83 | MP0001853_heart_inflammation | 0.75739198 |
| 84 | MP0001727_abnormal_embryo_implantation | 0.75642319 |
| 85 | MP0002095_abnormal_skin_pigmentation | 0.75624333 |
| 86 | MP0005253_abnormal_eye_physiology | 0.75061839 |
| 87 | MP0002233_abnormal_nose_morphology | 0.74691530 |
| 88 | MP0000703_abnormal_thymus_morphology | 0.74122317 |
| 89 | MP0001881_abnormal_mammary_gland | 0.72367303 |
| 90 | MP0001542_abnormal_bone_strength | 0.72273126 |
| 91 | MP0003698_abnormal_male_reproductive | 0.71462588 |
| 92 | MP0005332_abnormal_amino_acid | 0.71302625 |
| 93 | MP0001119_abnormal_female_reproductive | 0.71187590 |
| 94 | MP0005379_endocrine/exocrine_gland_phen | 0.70877946 |
| 95 | MP0001919_abnormal_reproductive_system | 0.70686819 |
| 96 | MP0003937_abnormal_limbs/digits/tail_de | 0.70651889 |
| 97 | MP0004147_increased_porphyrin_level | 0.69396482 |
| 98 | MP0005384_cellular_phenotype | 0.69336640 |
| 99 | MP0010030_abnormal_orbit_morphology | 0.68998911 |
| 100 | MP0008872_abnormal_physiological_respon | 0.68363562 |
| 101 | MP0003941_abnormal_skin_development | 0.67587478 |
| 102 | MP0005410_abnormal_fertilization | 0.67405407 |
| 103 | MP0000689_abnormal_spleen_morphology | 0.66199962 |
| 104 | MP0002090_abnormal_vision | 0.66163957 |
| 105 | MP0000647_abnormal_sebaceous_gland | 0.65921259 |
| 106 | MP0005266_abnormal_metabolism | 0.65738296 |
| 107 | MP0004808_abnormal_hematopoietic_stem | 0.65514574 |
| 108 | MP0002722_abnormal_immune_system | 0.65428291 |
| 109 | MP0001286_abnormal_eye_development | 0.65041642 |
| 110 | MP0000566_synostosis | 0.62265016 |
| 111 | MP0000750_abnormal_muscle_regeneration | 0.62225829 |
| 112 | MP0002398_abnormal_bone_marrow | 0.61823757 |
| 113 | MP0003950_abnormal_plasma_membrane | 0.61701114 |
| 114 | MP0002697_abnormal_eye_size | 0.61614621 |
| 115 | MP0003936_abnormal_reproductive_system | 0.61300843 |
| 116 | MP0010352_gastrointestinal_tract_polyps | 0.60680601 |
| 117 | MP0000631_abnormal_neuroendocrine_gland | 0.59769217 |
| 118 | MP0002111_abnormal_tail_morphology | 0.59545797 |
| 119 | MP0001661_extended_life_span | 0.58572015 |
| 120 | MP0008789_abnormal_olfactory_epithelium | 0.58394694 |
| 121 | MP0003119_abnormal_digestive_system | 0.58013417 |
| 122 | MP0009250_abnormal_appendicular_skeleto | 0.57559475 |
| 123 | MP0005636_abnormal_mineral_homeostasis | 0.57383679 |
| 124 | MP0005408_hypopigmentation | 0.56984629 |
| 125 | MP0005409_darkened_coat_color | 0.56185691 |
| 126 | MP0005395_other_phenotype | 0.55679172 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.40167580 |
| 2 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.78725628 |
| 3 | Abnormal number of erythroid precursors (HP:0012131) | 4.54145721 |
| 4 | Reticulocytopenia (HP:0001896) | 4.31556505 |
| 5 | Breast hypoplasia (HP:0003187) | 4.26943732 |
| 6 | Cerebral hypomyelination (HP:0006808) | 3.81343825 |
| 7 | Acute necrotizing encephalopathy (HP:0006965) | 3.59251407 |
| 8 | Rough bone trabeculation (HP:0100670) | 3.56682898 |
| 9 | Oral leukoplakia (HP:0002745) | 3.47917495 |
| 10 | Macrocytic anemia (HP:0001972) | 3.46846369 |
| 11 | Mitochondrial inheritance (HP:0001427) | 3.41703791 |
| 12 | Aplastic anemia (HP:0001915) | 3.31968491 |
| 13 | Increased hepatocellular lipid droplets (HP:0006565) | 3.31741648 |
| 14 | Cerebral edema (HP:0002181) | 3.28856583 |
| 15 | Abnormality of glycolysis (HP:0004366) | 3.24823154 |
| 16 | Increased serum pyruvate (HP:0003542) | 3.24823154 |
| 17 | Carpal bone hypoplasia (HP:0001498) | 3.16533832 |
| 18 | Increased CSF lactate (HP:0002490) | 3.15175567 |
| 19 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.09554199 |
| 20 | Irregular epiphyses (HP:0010582) | 3.07538579 |
| 21 | Chromsome breakage (HP:0040012) | 2.95408543 |
| 22 | Patellar aplasia (HP:0006443) | 2.94882068 |
| 23 | Pallor (HP:0000980) | 2.94857513 |
| 24 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.92230685 |
| 25 | Hepatocellular necrosis (HP:0001404) | 2.90224505 |
| 26 | Progressive macrocephaly (HP:0004481) | 2.87706689 |
| 27 | Increased serum lactate (HP:0002151) | 2.85820168 |
| 28 | Abnormality of the preputium (HP:0100587) | 2.83394639 |
| 29 | Abnormality of the pons (HP:0007361) | 2.80837210 |
| 30 | Reduced antithrombin III activity (HP:0001976) | 2.79639800 |
| 31 | Methylmalonic acidemia (HP:0002912) | 2.78591950 |
| 32 | 3-Methylglutaconic aciduria (HP:0003535) | 2.77327302 |
| 33 | Premature graying of hair (HP:0002216) | 2.77164141 |
| 34 | Lipid accumulation in hepatocytes (HP:0006561) | 2.76790196 |
| 35 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.76503099 |
| 36 | Increased intramyocellular lipid droplets (HP:0012240) | 2.75738338 |
| 37 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.74778442 |
| 38 | Abnormal trabecular bone morphology (HP:0100671) | 2.71775635 |
| 39 | Methylmalonic aciduria (HP:0012120) | 2.67478230 |
| 40 | Abnormality of the labia minora (HP:0012880) | 2.67041038 |
| 41 | Acute encephalopathy (HP:0006846) | 2.65934386 |
| 42 | Abnormality of methionine metabolism (HP:0010901) | 2.65550022 |
| 43 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.62969799 |
| 44 | Meckel diverticulum (HP:0002245) | 2.58978061 |
| 45 | Abnormality of chromosome stability (HP:0003220) | 2.58117729 |
| 46 | Absent radius (HP:0003974) | 2.53775419 |
| 47 | Hypoplasia of the pons (HP:0012110) | 2.50480107 |
| 48 | Absent thumb (HP:0009777) | 2.46638715 |
| 49 | Microvesicular hepatic steatosis (HP:0001414) | 2.46497673 |
| 50 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.45622081 |
| 51 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.45622081 |
| 52 | Abnormality of the anterior horn cell (HP:0006802) | 2.44453617 |
| 53 | Degeneration of anterior horn cells (HP:0002398) | 2.44453617 |
| 54 | Colon cancer (HP:0003003) | 2.44007510 |
| 55 | Secondary amenorrhea (HP:0000869) | 2.41441234 |
| 56 | Horseshoe kidney (HP:0000085) | 2.41229294 |
| 57 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.40471029 |
| 58 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.40471029 |
| 59 | Abnormal protein glycosylation (HP:0012346) | 2.40471029 |
| 60 | Abnormal glycosylation (HP:0012345) | 2.40471029 |
| 61 | 11 pairs of ribs (HP:0000878) | 2.39724052 |
| 62 | CNS hypomyelination (HP:0003429) | 2.39557763 |
| 63 | Glossoptosis (HP:0000162) | 2.39503669 |
| 64 | Abnormality of the ileum (HP:0001549) | 2.39317372 |
| 65 | Abnormality of serum amino acid levels (HP:0003112) | 2.36120827 |
| 66 | Aplasia involving forearm bones (HP:0009822) | 2.35612255 |
| 67 | Absent forearm bone (HP:0003953) | 2.35612255 |
| 68 | Renal Fanconi syndrome (HP:0001994) | 2.33610828 |
| 69 | Exertional dyspnea (HP:0002875) | 2.33439444 |
| 70 | Hepatic necrosis (HP:0002605) | 2.30384728 |
| 71 | Impulsivity (HP:0100710) | 2.29190107 |
| 72 | Selective tooth agenesis (HP:0001592) | 2.27305882 |
| 73 | Supernumerary spleens (HP:0009799) | 2.27269805 |
| 74 | Pancytopenia (HP:0001876) | 2.26796444 |
| 75 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.24933781 |
| 76 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.24498228 |
| 77 | Exercise intolerance (HP:0003546) | 2.23860704 |
| 78 | Congenital, generalized hypertrichosis (HP:0004540) | 2.23447513 |
| 79 | Abnormal lung lobation (HP:0002101) | 2.22199756 |
| 80 | Bone marrow hypocellularity (HP:0005528) | 2.20898346 |
| 81 | Megaloblastic anemia (HP:0001889) | 2.20148765 |
| 82 | Type I transferrin isoform profile (HP:0003642) | 2.18492507 |
| 83 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.18102537 |
| 84 | Respiratory difficulties (HP:0002880) | 2.17489896 |
| 85 | Increased muscle lipid content (HP:0009058) | 2.17047371 |
| 86 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.16825876 |
| 87 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.15816154 |
| 88 | Cellular immunodeficiency (HP:0005374) | 2.14620855 |
| 89 | Hyperglycinemia (HP:0002154) | 2.14158286 |
| 90 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.12983381 |
| 91 | Absent epiphyses (HP:0010577) | 2.12983381 |
| 92 | Abnormality of renal resorption (HP:0011038) | 2.12792590 |
| 93 | Triphalangeal thumb (HP:0001199) | 2.11807411 |
| 94 | Lethargy (HP:0001254) | 2.11493525 |
| 95 | Duplicated collecting system (HP:0000081) | 2.08560849 |
| 96 | Agnosia (HP:0010524) | 2.04634579 |
| 97 | Optic disc pallor (HP:0000543) | 2.04235585 |
| 98 | Duodenal stenosis (HP:0100867) | 2.02966146 |
| 99 | Small intestinal stenosis (HP:0012848) | 2.02966146 |
| 100 | Respiratory failure (HP:0002878) | 2.02931660 |
| 101 | Postnatal microcephaly (HP:0005484) | 2.02315029 |
| 102 | Myelodysplasia (HP:0002863) | 2.00737652 |
| 103 | Cleft eyelid (HP:0000625) | 1.98035117 |
| 104 | Lactic acidosis (HP:0003128) | 1.95247252 |
| 105 | Microretrognathia (HP:0000308) | 1.94784629 |
| 106 | Premature ovarian failure (HP:0008209) | 1.94051492 |
| 107 | Medulloblastoma (HP:0002885) | 1.92965927 |
| 108 | Trismus (HP:0000211) | 1.91975211 |
| 109 | Sloping forehead (HP:0000340) | 1.91920791 |
| 110 | Neoplasm of the pancreas (HP:0002894) | 1.91157031 |
| 111 | Sparse eyelashes (HP:0000653) | 1.89123298 |
| 112 | Homocystinuria (HP:0002156) | 1.88436899 |
| 113 | Abnormality of homocysteine metabolism (HP:0010919) | 1.88436899 |
| 114 | Abnormality of the duodenum (HP:0002246) | 1.87647257 |
| 115 | Emotional lability (HP:0000712) | 1.86621521 |
| 116 | Hypoplasia of the radius (HP:0002984) | 1.84409089 |
| 117 | Type 2 muscle fiber atrophy (HP:0003554) | 1.84291736 |
| 118 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.83850048 |
| 119 | Leukodystrophy (HP:0002415) | 1.82905941 |
| 120 | Abnormality of the renal collecting system (HP:0004742) | 1.82756991 |
| 121 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.82614076 |
| 122 | Abnormality of alanine metabolism (HP:0010916) | 1.82614076 |
| 123 | Hyperalaninemia (HP:0003348) | 1.82614076 |
| 124 | Multiple enchondromatosis (HP:0005701) | 1.81641794 |
| 125 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.81089938 |
| 126 | Stenosis of the external auditory canal (HP:0000402) | 1.80874912 |
| 127 | Embryonal renal neoplasm (HP:0011794) | 1.79131045 |
| 128 | Abnormality of placental membranes (HP:0011409) | 1.77435966 |
| 129 | Amniotic constriction ring (HP:0009775) | 1.77435966 |
| 130 | Neoplasm of the adrenal gland (HP:0100631) | 1.76740828 |
| 131 | Neoplasm of the colon (HP:0100273) | 1.75655634 |
| 132 | Abnormality of glycine metabolism (HP:0010895) | 1.70563693 |
| 133 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.70563693 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.02787311 |
| 2 | EIF2AK1 | 4.37951635 |
| 3 | WEE1 | 4.26411329 |
| 4 | VRK2 | 3.38574097 |
| 5 | STK16 | 3.17208775 |
| 6 | SRPK1 | 2.99881836 |
| 7 | EIF2AK3 | 2.92571797 |
| 8 | CDC7 | 2.90645355 |
| 9 | TSSK6 | 2.57301096 |
| 10 | VRK1 | 2.47571866 |
| 11 | NME2 | 2.46925305 |
| 12 | MKNK1 | 2.38790732 |
| 13 | NUAK1 | 2.23571479 |
| 14 | BRSK2 | 2.18776453 |
| 15 | PLK4 | 2.13259212 |
| 16 | ACVR1B | 2.10141970 |
| 17 | MKNK2 | 2.05609346 |
| 18 | PBK | 2.01599027 |
| 19 | MST4 | 1.94037514 |
| 20 | PLK3 | 1.93167345 |
| 21 | TAF1 | 1.90512628 |
| 22 | NME1 | 1.81228508 |
| 23 | PLK1 | 1.76374934 |
| 24 | TLK1 | 1.66493014 |
| 25 | TTK | 1.64260113 |
| 26 | TRIM28 | 1.61689245 |
| 27 | TESK2 | 1.60757607 |
| 28 | PNCK | 1.60677568 |
| 29 | NEK1 | 1.51381345 |
| 30 | NEK2 | 1.44659876 |
| 31 | AURKB | 1.43165697 |
| 32 | DYRK3 | 1.35502098 |
| 33 | ATR | 1.27272367 |
| 34 | CCNB1 | 1.25661016 |
| 35 | AURKA | 1.21828373 |
| 36 | BRSK1 | 1.19428255 |
| 37 | ZAK | 1.17287901 |
| 38 | CDK7 | 1.16798135 |
| 39 | EIF2AK2 | 1.12841550 |
| 40 | CHEK2 | 1.10082508 |
| 41 | INSRR | 1.04093140 |
| 42 | PIM2 | 1.00202961 |
| 43 | RPS6KB2 | 0.97649728 |
| 44 | CHEK1 | 0.93549215 |
| 45 | MAP3K12 | 0.91897309 |
| 46 | RPS6KA4 | 0.91675592 |
| 47 | CDK8 | 0.89866828 |
| 48 | EPHA2 | 0.85838901 |
| 49 | CSNK2A2 | 0.85472307 |
| 50 | PASK | 0.84507895 |
| 51 | DYRK2 | 0.82716510 |
| 52 | CSNK2A1 | 0.81125990 |
| 53 | STK3 | 0.79856439 |
| 54 | BRAF | 0.74917554 |
| 55 | BCR | 0.73723290 |
| 56 | MAP4K2 | 0.71745367 |
| 57 | LATS1 | 0.69827554 |
| 58 | ATM | 0.68181327 |
| 59 | MAP3K8 | 0.67804490 |
| 60 | LIMK1 | 0.67463145 |
| 61 | BMPR1B | 0.67384076 |
| 62 | STK39 | 0.65635434 |
| 63 | BCKDK | 0.64339625 |
| 64 | PAK1 | 0.61309195 |
| 65 | RPS6KA5 | 0.60968959 |
| 66 | TNIK | 0.60175245 |
| 67 | STK4 | 0.60092451 |
| 68 | MAPKAPK5 | 0.59913386 |
| 69 | CDK2 | 0.58344332 |
| 70 | ADRBK2 | 0.58013117 |
| 71 | GRK1 | 0.56321904 |
| 72 | PDK3 | 0.56312630 |
| 73 | PDK4 | 0.56312630 |
| 74 | PRKCI | 0.55234481 |
| 75 | TGFBR1 | 0.54757788 |
| 76 | CDK1 | 0.52277802 |
| 77 | NEK6 | 0.51901566 |
| 78 | CDK4 | 0.50505463 |
| 79 | CSNK1G3 | 0.49983070 |
| 80 | ABL2 | 0.48505252 |
| 81 | PAK4 | 0.48078168 |
| 82 | OXSR1 | 0.47767407 |
| 83 | MELK | 0.45497045 |
| 84 | ERBB4 | 0.44418213 |
| 85 | CASK | 0.43568122 |
| 86 | YES1 | 0.42687430 |
| 87 | CSNK1G2 | 0.42617791 |
| 88 | FGFR1 | 0.41397989 |
| 89 | PDK2 | 0.40833982 |
| 90 | PIM1 | 0.38916510 |
| 91 | WNK4 | 0.38258018 |
| 92 | CDK19 | 0.37349853 |
| 93 | PLK2 | 0.37285283 |
| 94 | CSNK1E | 0.36619443 |
| 95 | DAPK1 | 0.36197517 |
| 96 | STK38L | 0.34929900 |
| 97 | AKT3 | 0.34572815 |
| 98 | TXK | 0.33862010 |
| 99 | CSNK1A1L | 0.33523989 |
| 100 | TESK1 | 0.32901184 |
| 101 | CLK1 | 0.31605074 |
| 102 | FRK | 0.31535948 |
| 103 | MAP3K11 | 0.29568579 |
| 104 | TEC | 0.29465988 |
| 105 | WNK3 | 0.29256206 |
| 106 | STK24 | 0.28954581 |
| 107 | IRAK4 | 0.28681017 |
| 108 | NLK | 0.28279728 |
| 109 | STK10 | 0.28102192 |
| 110 | CDK11A | 0.28047776 |
| 111 | KDR | 0.27954429 |
| 112 | CDK18 | 0.27232962 |
| 113 | ERBB3 | 0.26486970 |
| 114 | MAP3K4 | 0.26335356 |
| 115 | CDK14 | 0.26175034 |
| 116 | CSNK1G1 | 0.25968703 |
| 117 | MAPKAPK3 | 0.25882291 |
| 118 | CDK15 | 0.24361957 |
| 119 | TAOK2 | 0.24107141 |
| 120 | SCYL2 | 0.23029319 |
| 121 | PRKCG | 0.22225396 |
| 122 | PRKDC | 0.21857416 |
| 123 | OBSCN | 0.20828922 |
| 124 | CSNK1A1 | 0.20703484 |
| 125 | CDK9 | 0.20625830 |
| 126 | IRAK3 | 0.20608063 |
| 127 | ALK | 0.19813602 |
| 128 | ILK | 0.18825581 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.61989573 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.40500385 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 4.31787776 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 4.07686015 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.04553862 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 3.69689944 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 3.29335460 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 2.98126181 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.84680305 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.80071213 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.70509626 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 2.41899080 |
| 13 | Basal transcription factors_Homo sapiens_hsa03022 | 2.28650972 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.21499741 |
| 15 | Cell cycle_Homo sapiens_hsa04110 | 2.16255465 |
| 16 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.10753673 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.07496242 |
| 18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.04578525 |
| 19 | Protein export_Homo sapiens_hsa03060 | 2.01757622 |
| 20 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.00968645 |
| 21 | Parkinsons disease_Homo sapiens_hsa05012 | 1.94396179 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.88042579 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.71079034 |
| 24 | Purine metabolism_Homo sapiens_hsa00230 | 1.62150732 |
| 25 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.59789080 |
| 26 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.35824852 |
| 27 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.33094248 |
| 28 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.31735718 |
| 29 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.19787546 |
| 30 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.19706473 |
| 31 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.15664715 |
| 32 | Alzheimers disease_Homo sapiens_hsa05010 | 1.14376115 |
| 33 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.13501866 |
| 34 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.08210380 |
| 35 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.94285881 |
| 36 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.92727767 |
| 37 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.88870204 |
| 38 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.88499086 |
| 39 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.84847049 |
| 40 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.80792576 |
| 41 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.78987763 |
| 42 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.78101432 |
| 43 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.77148325 |
| 44 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.72621469 |
| 45 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.68002653 |
| 46 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.67932757 |
| 47 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.66192285 |
| 48 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.59859059 |
| 49 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.56369319 |
| 50 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.55702337 |
| 51 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.54203404 |
| 52 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.53602600 |
| 53 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.53560390 |
| 54 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.52982315 |
| 55 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.52734646 |
| 56 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.52436755 |
| 57 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.52083042 |
| 58 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.50632858 |
| 59 | Peroxisome_Homo sapiens_hsa04146 | 0.49847394 |
| 60 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.48323899 |
| 61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.47667531 |
| 62 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.44976791 |
| 63 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.43810558 |
| 64 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.42495473 |
| 65 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.42033126 |
| 66 | Sulfur relay system_Homo sapiens_hsa04122 | 0.41855501 |
| 67 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.41746126 |
| 68 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.41370537 |
| 69 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.41211702 |
| 70 | Alcoholism_Homo sapiens_hsa05034 | 0.40070357 |
| 71 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.38849201 |
| 72 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.38577272 |
| 73 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.37258413 |
| 74 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.37064607 |
| 75 | Allograft rejection_Homo sapiens_hsa05330 | 0.36284241 |
| 76 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.35851850 |
| 77 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.35750870 |
| 78 | Retinol metabolism_Homo sapiens_hsa00830 | 0.35148273 |
| 79 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.33367076 |
| 80 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.32759884 |
| 81 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.31279433 |
| 82 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.31050958 |
| 83 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.29484533 |
| 84 | Carbon metabolism_Homo sapiens_hsa01200 | 0.27306811 |
| 85 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.26354976 |
| 86 | HTLV-I infection_Homo sapiens_hsa05166 | 0.25487861 |
| 87 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.25380166 |
| 88 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.23779911 |
| 89 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.23114808 |
| 90 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.22771795 |
| 91 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.21465933 |
| 92 | Legionellosis_Homo sapiens_hsa05134 | 0.20942647 |
| 93 | Asthma_Homo sapiens_hsa05310 | 0.20823364 |
| 94 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.20575526 |
| 95 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.19574633 |
| 96 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.19415714 |
| 97 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.19247558 |
| 98 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.17241087 |
| 99 | Thyroid cancer_Homo sapiens_hsa05216 | 0.17180395 |
| 100 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.17163444 |
| 101 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.14978594 |
| 102 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.14692544 |
| 103 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.14662462 |
| 104 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.12361920 |
| 105 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.11395146 |
| 106 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.10931120 |
| 107 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.10848368 |
| 108 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.09493861 |
| 109 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.09197298 |
| 110 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.08774099 |
| 111 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.08626228 |
| 112 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.07885692 |
| 113 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.07801393 |
| 114 | Shigellosis_Homo sapiens_hsa05131 | 0.07757996 |
| 115 | Mineral absorption_Homo sapiens_hsa04978 | 0.07451916 |
| 116 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.07399413 |
| 117 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.07054180 |
| 118 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.07019110 |
| 119 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.06841559 |
| 120 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.06047046 |
| 121 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.05592296 |
| 122 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.05368281 |
| 123 | Phototransduction_Homo sapiens_hsa04744 | 0.04978896 |
| 124 | Measles_Homo sapiens_hsa05162 | 0.04806569 |
| 125 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.04689641 |
| 126 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.03613403 |
| 127 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.02434878 |
| 128 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.02225768 |
| 129 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | -0.0224885 |
| 130 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | -0.0091429 |
| 131 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | -0.0058185 |
| 132 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | -0.0050427 |

