RPF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.89522819
2ribosomal small subunit assembly (GO:0000028)4.73289888
3ribosomal small subunit biogenesis (GO:0042274)4.67294173
4proteasome assembly (GO:0043248)4.60726795
5chaperone-mediated protein transport (GO:0072321)4.53490433
6ribosomal large subunit biogenesis (GO:0042273)4.47441052
7nucleobase biosynthetic process (GO:0046112)4.43927325
8formation of translation preinitiation complex (GO:0001731)4.39965764
9purine nucleobase biosynthetic process (GO:0009113)4.37396571
10ribonucleoprotein complex biogenesis (GO:0022613)4.33735797
11viral transcription (GO:0019083)4.29616989
12translational termination (GO:0006415)4.27090333
13CENP-A containing nucleosome assembly (GO:0034080)4.26659861
14ribosome biogenesis (GO:0042254)4.18972592
15termination of RNA polymerase III transcription (GO:0006386)4.15003763
16transcription elongation from RNA polymerase III promoter (GO:0006385)4.15003763
17DNA replication checkpoint (GO:0000076)4.14565601
18chromatin remodeling at centromere (GO:0031055)4.13752360
19DNA strand elongation involved in DNA replication (GO:0006271)4.08867143
20ribosome assembly (GO:0042255)4.08085031
21mitotic metaphase plate congression (GO:0007080)4.05068849
22spliceosomal snRNP assembly (GO:0000387)4.05068286
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.01657944
24DNA replication initiation (GO:0006270)4.01397796
25telomere maintenance via semi-conservative replication (GO:0032201)3.99941835
26rRNA processing (GO:0006364)3.96262273
277-methylguanosine mRNA capping (GO:0006370)3.94400919
287-methylguanosine RNA capping (GO:0009452)3.91565224
29RNA capping (GO:0036260)3.91565224
30rRNA modification (GO:0000154)3.91292113
31translational initiation (GO:0006413)3.90061832
32cullin deneddylation (GO:0010388)3.88642305
33DNA strand elongation (GO:0022616)3.88073797
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.87277179
35transcription elongation from RNA polymerase I promoter (GO:0006362)3.87026395
36regulation of mitochondrial translation (GO:0070129)3.86660159
37pseudouridine synthesis (GO:0001522)3.85121289
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.85066939
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.84381215
40rRNA metabolic process (GO:0016072)3.82842152
41translational elongation (GO:0006414)3.82006350
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.80594138
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.80010668
44termination of RNA polymerase I transcription (GO:0006363)3.78344695
45cotranslational protein targeting to membrane (GO:0006613)3.76821322
46protein targeting to ER (GO:0045047)3.71807909
47DNA deamination (GO:0045006)3.70742119
48DNA replication-independent nucleosome assembly (GO:0006336)3.68394350
49DNA replication-independent nucleosome organization (GO:0034724)3.68394350
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.68109820
51negative regulation of ligase activity (GO:0051352)3.68109820
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.66088344
53telomere maintenance via recombination (GO:0000722)3.64460450
54kinetochore organization (GO:0051383)3.64297545
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.64276028
56protein deneddylation (GO:0000338)3.62442914
57transcription-coupled nucleotide-excision repair (GO:0006283)3.60146776
58DNA damage response, detection of DNA damage (GO:0042769)3.58974577
59establishment of integrated proviral latency (GO:0075713)3.57898520
60cellular component biogenesis (GO:0044085)3.57703777
61spliceosomal complex assembly (GO:0000245)3.56761828
62kinetochore assembly (GO:0051382)3.56188101
63protein localization to endoplasmic reticulum (GO:0070972)3.54945290
64translation (GO:0006412)3.54297749
65establishment of protein localization to endoplasmic reticulum (GO:0072599)3.53520256
66mitochondrial respiratory chain complex assembly (GO:0033108)3.53303105
67transcription from RNA polymerase I promoter (GO:0006360)3.52964595
68nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50457866
69histone exchange (GO:0043486)3.48537447
70cellular protein complex disassembly (GO:0043624)3.48276838
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.48098935
72regulation of cellular amino acid metabolic process (GO:0006521)3.47492912
73protein targeting to mitochondrion (GO:0006626)3.44404944
74protein complex biogenesis (GO:0070271)3.44230761
75mitotic recombination (GO:0006312)3.44203881
76signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.43679665
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.43679665
78metaphase plate congression (GO:0051310)3.43106831
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.41886683
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.41886683
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.41886683
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.41000772
83respiratory electron transport chain (GO:0022904)3.39488589
84signal transduction involved in DNA integrity checkpoint (GO:0072401)3.37900743
85signal transduction involved in DNA damage checkpoint (GO:0072422)3.37900743
86DNA double-strand break processing (GO:0000729)3.37088048
87viral life cycle (GO:0019058)3.34540932
88DNA replication-dependent nucleosome assembly (GO:0006335)3.34479477
89DNA replication-dependent nucleosome organization (GO:0034723)3.34479477
90signal transduction involved in cell cycle checkpoint (GO:0072395)3.33861127
91respiratory chain complex IV assembly (GO:0008535)3.33109460
92IMP biosynthetic process (GO:0006188)3.32501424
93electron transport chain (GO:0022900)3.32127538
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31916744
95mitochondrial respiratory chain complex I assembly (GO:0032981)3.31916744
96NADH dehydrogenase complex assembly (GO:0010257)3.31916744
97G1/S transition of mitotic cell cycle (GO:0000082)3.31504375
98cell cycle G1/S phase transition (GO:0044843)3.31504375
99mitochondrial RNA metabolic process (GO:0000959)3.29943878
100telomere maintenance via telomere lengthening (GO:0010833)3.29457798
101folic acid-containing compound biosynthetic process (GO:0009396)3.29384632
102transcription initiation from RNA polymerase I promoter (GO:0006361)3.27046877
103positive regulation of ligase activity (GO:0051351)3.26559006
104energy coupled proton transport, down electrochemical gradient (GO:0015985)3.26142930
105ATP synthesis coupled proton transport (GO:0015986)3.26142930
106IMP metabolic process (GO:0046040)3.25352502
107maturation of 5.8S rRNA (GO:0000460)3.23983922
108tRNA aminoacylation (GO:0043039)3.23317637
109amino acid activation (GO:0043038)3.23317637
110protein localization to mitochondrion (GO:0070585)3.22877700
111protein neddylation (GO:0045116)3.22627464
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21248827
113DNA catabolic process, exonucleolytic (GO:0000738)3.20802604
114histone mRNA metabolic process (GO:0008334)3.20280709
115tRNA aminoacylation for protein translation (GO:0006418)3.20226638
116nucleotide-excision repair, DNA gap filling (GO:0006297)3.19704140
117protein localization to kinetochore (GO:0034501)3.16674692
118transcription from mitochondrial promoter (GO:0006390)3.16669125
119establishment of protein localization to mitochondrion (GO:0072655)3.16115574
120rRNA methylation (GO:0031167)3.14843899
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13657889
122mitotic nuclear envelope disassembly (GO:0007077)3.12640145
123regulation of mitotic spindle checkpoint (GO:1903504)3.12522810
124regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12522810
125viral mRNA export from host cell nucleus (GO:0046784)3.11894073
126regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11343589
127L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.11295779
128water-soluble vitamin biosynthetic process (GO:0042364)3.11078060
129establishment of chromosome localization (GO:0051303)3.10712151
130regulation of ubiquitin-protein transferase activity (GO:0051438)3.07345033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.72962936
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.78387249
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.41701674
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.07397089
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.02821051
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66979865
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57630811
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.53868242
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.52594836
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.36745458
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.25860980
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24659453
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.17138885
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.15015864
15MYC_19030024_ChIP-ChIP_MESCs_Mouse3.08567247
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.99046316
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.90627732
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80793655
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.78905981
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75286454
21VDR_23849224_ChIP-Seq_CD4+_Human2.72143807
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70820360
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49850750
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.49464843
25* XRN2_22483619_ChIP-Seq_HELA_Human2.45693205
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29393824
27DCP1A_22483619_ChIP-Seq_HELA_Human2.27299453
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27223187
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25758710
30ELK1_19687146_ChIP-ChIP_HELA_Human2.25511163
31FOXP3_21729870_ChIP-Seq_TREG_Human2.24607874
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19934971
33TTF2_22483619_ChIP-Seq_HELA_Human2.08898009
34GABP_19822575_ChIP-Seq_HepG2_Human2.02041359
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01541424
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.94709627
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91621240
38* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90735316
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90177833
40AR_21909140_ChIP-Seq_LNCAP_Human1.89721058
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87806960
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86900418
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84960801
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.84170775
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80742086
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70548338
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65115102
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.64831060
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64747348
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63556954
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61732630
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47185801
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45102164
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44506116
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41098164
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37419910
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34368792
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.32651523
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.29994311
60EWS_26573619_Chip-Seq_HEK293_Human1.29093793
61MYC_18940864_ChIP-ChIP_HL60_Human1.28660812
62KDM5A_27292631_Chip-Seq_BREAST_Human1.28309652
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27653604
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27266072
65VDR_22108803_ChIP-Seq_LS180_Human1.26828851
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25735341
67CIITA_25753668_ChIP-Seq_RAJI_Human1.25701090
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22523725
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18480781
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09559286
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09552916
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06117845
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.02754637
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02494227
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01720545
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01302600
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99268503
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98232803
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96720775
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95702555
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95031852
82IRF1_19129219_ChIP-ChIP_H3396_Human0.94151317
83ZNF274_21170338_ChIP-Seq_K562_Hela0.89291093
84KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89178562
85POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87802352
86SOX17_20123909_ChIP-Seq_XEN_Mouse0.87264340
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86806684
88TP63_19390658_ChIP-ChIP_HaCaT_Human0.86786134
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86643264
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85795648
91STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85784002
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85318954
93TFEB_21752829_ChIP-Seq_HELA_Human0.84927078
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82691852
95ELF5_23300383_ChIP-Seq_T47D_Human0.80150146
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77492456
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77323842
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76618273
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76505539
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76234455
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74003622
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73475128
103* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73308507
104SALL1_21062744_ChIP-ChIP_HESCs_Human0.71530674
105PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70934292
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.69840244
107SPI1_23547873_ChIP-Seq_NB4_Human0.68519239
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.67207640
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.66004102
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.65512309
111FUS_26573619_Chip-Seq_HEK293_Human0.64960885
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.64688764
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.64012793
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.63770976
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.62866212
116TP53_22573176_ChIP-Seq_HFKS_Human0.61198322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.99389404
2MP0004957_abnormal_blastocyst_morpholog4.88119317
3MP0010094_abnormal_chromosome_stability4.65467504
4MP0003111_abnormal_nucleus_morphology4.28441227
5MP0008057_abnormal_DNA_replication4.23846842
6MP0003077_abnormal_cell_cycle4.03093880
7MP0008058_abnormal_DNA_repair3.99936642
8MP0008932_abnormal_embryonic_tissue3.10277825
9MP0008007_abnormal_cellular_replicative2.76449070
10MP0003123_paternal_imprinting2.67151923
11MP0003786_premature_aging2.54236681
12MP0008877_abnormal_DNA_methylation2.47963381
13MP0009379_abnormal_foot_pigmentation2.44558617
14MP0003718_maternal_effect2.44099292
15MP0001730_embryonic_growth_arrest2.18914475
16MP0001529_abnormal_vocalization1.94678226
17MP0000350_abnormal_cell_proliferation1.93764950
18MP0002396_abnormal_hematopoietic_system1.83406723
19MP0003806_abnormal_nucleotide_metabolis1.80342419
20MP0006292_abnormal_olfactory_placode1.77239824
21MP0006072_abnormal_retinal_apoptosis1.70735771
22MP0003136_yellow_coat_color1.52961809
23MP0002837_dystrophic_cardiac_calcinosis1.52300943
24MP0003315_abnormal_perineum_morphology1.51084342
25MP0001697_abnormal_embryo_size1.45992905
26MP0002210_abnormal_sex_determination1.43670609
27MP0009333_abnormal_splenocyte_physiolog1.41391920
28MP0001672_abnormal_embryogenesis/_devel1.35609133
29MP0005380_embryogenesis_phenotype1.35609133
30MP0003186_abnormal_redox_activity1.35316680
31MP0002102_abnormal_ear_morphology1.34649991
32MP0002080_prenatal_lethality1.34417967
33MP0003121_genomic_imprinting1.32181615
34MP0000313_abnormal_cell_death1.29070750
35MP0006035_abnormal_mitochondrial_morpho1.28732723
36MP0003567_abnormal_fetal_cardiomyocyte1.25425175
37MP0006036_abnormal_mitochondrial_physio1.23445577
38MP0001145_abnormal_male_reproductive1.22473652
39MP0002085_abnormal_embryonic_tissue1.17331756
40MP0005084_abnormal_gallbladder_morpholo1.16723961
41MP0001929_abnormal_gametogenesis1.16621015
42MP0000490_abnormal_crypts_of1.15644741
43MP0003984_embryonic_growth_retardation1.13184151
44MP0002132_abnormal_respiratory_system1.12568218
45MP0002938_white_spotting1.10951185
46MP0009697_abnormal_copulation1.10639532
47MP0003890_abnormal_embryonic-extraembry1.10365545
48MP0001986_abnormal_taste_sensitivity1.09463056
49MP0004133_heterotaxia1.09455986
50MP0002088_abnormal_embryonic_growth/wei1.09059636
51MP0002019_abnormal_tumor_incidence1.06995124
52MP0000653_abnormal_sex_gland1.06365678
53MP0000358_abnormal_cell_content/1.04702125
54MP0002160_abnormal_reproductive_system1.02476919
55MP0001905_abnormal_dopamine_level1.02221530
56MP0002751_abnormal_autonomic_nervous1.01506056
57MP0004215_abnormal_myocardial_fiber1.00935315
58MP0002084_abnormal_developmental_patter1.00679749
59MP0001188_hyperpigmentation0.98542886
60MP0002277_abnormal_respiratory_mucosa0.98159139
61MP0010307_abnormal_tumor_latency0.96893075
62MP0003011_delayed_dark_adaptation0.96647472
63MP0002163_abnormal_gland_morphology0.95815039
64MP0001293_anophthalmia0.95059179
65MP0005389_reproductive_system_phenotype0.93586148
66MP0002638_abnormal_pupillary_reflex0.92286720
67MP0008995_early_reproductive_senescence0.89622318
68MP0002234_abnormal_pharynx_morphology0.88621319
69MP0003221_abnormal_cardiomyocyte_apopto0.88306746
70MP0008260_abnormal_autophagy0.87879732
71MP0003195_calcinosis0.87668993
72MP0004197_abnormal_fetal_growth/weight/0.87558359
73MP0009672_abnormal_birth_weight0.84770873
74MP0005075_abnormal_melanosome_morpholog0.82890196
75MP0001485_abnormal_pinna_reflex0.82006132
76MP0002736_abnormal_nociception_after0.81991707
77MP0002086_abnormal_extraembryonic_tissu0.81913985
78MP0000372_irregular_coat_pigmentation0.81192844
79MP0003938_abnormal_ear_development0.81073398
80MP0003763_abnormal_thymus_physiology0.80795642
81MP0000049_abnormal_middle_ear0.80195381
82MP0001764_abnormal_homeostasis0.76134268
83MP0001853_heart_inflammation0.75739198
84MP0001727_abnormal_embryo_implantation0.75642319
85MP0002095_abnormal_skin_pigmentation0.75624333
86MP0005253_abnormal_eye_physiology0.75061839
87MP0002233_abnormal_nose_morphology0.74691530
88MP0000703_abnormal_thymus_morphology0.74122317
89MP0001881_abnormal_mammary_gland0.72367303
90MP0001542_abnormal_bone_strength0.72273126
91MP0003698_abnormal_male_reproductive0.71462588
92MP0005332_abnormal_amino_acid0.71302625
93MP0001119_abnormal_female_reproductive0.71187590
94MP0005379_endocrine/exocrine_gland_phen0.70877946
95MP0001919_abnormal_reproductive_system0.70686819
96MP0003937_abnormal_limbs/digits/tail_de0.70651889
97MP0004147_increased_porphyrin_level0.69396482
98MP0005384_cellular_phenotype0.69336640
99MP0010030_abnormal_orbit_morphology0.68998911
100MP0008872_abnormal_physiological_respon0.68363562
101MP0003941_abnormal_skin_development0.67587478
102MP0005410_abnormal_fertilization0.67405407
103MP0000689_abnormal_spleen_morphology0.66199962
104MP0002090_abnormal_vision0.66163957
105MP0000647_abnormal_sebaceous_gland0.65921259
106MP0005266_abnormal_metabolism0.65738296
107MP0004808_abnormal_hematopoietic_stem0.65514574
108MP0002722_abnormal_immune_system0.65428291
109MP0001286_abnormal_eye_development0.65041642
110MP0000566_synostosis0.62265016
111MP0000750_abnormal_muscle_regeneration0.62225829
112MP0002398_abnormal_bone_marrow0.61823757
113MP0003950_abnormal_plasma_membrane0.61701114
114MP0002697_abnormal_eye_size0.61614621
115MP0003936_abnormal_reproductive_system0.61300843
116MP0010352_gastrointestinal_tract_polyps0.60680601
117MP0000631_abnormal_neuroendocrine_gland0.59769217
118MP0002111_abnormal_tail_morphology0.59545797
119MP0001661_extended_life_span0.58572015
120MP0008789_abnormal_olfactory_epithelium0.58394694
121MP0003119_abnormal_digestive_system0.58013417
122MP0009250_abnormal_appendicular_skeleto0.57559475
123MP0005636_abnormal_mineral_homeostasis0.57383679
124MP0005408_hypopigmentation0.56984629
125MP0005409_darkened_coat_color0.56185691
126MP0005395_other_phenotype0.55679172

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.40167580
2Abnormality of cells of the erythroid lineage (HP:0012130)4.78725628
3Abnormal number of erythroid precursors (HP:0012131)4.54145721
4Reticulocytopenia (HP:0001896)4.31556505
5Breast hypoplasia (HP:0003187)4.26943732
6Cerebral hypomyelination (HP:0006808)3.81343825
7Acute necrotizing encephalopathy (HP:0006965)3.59251407
8Rough bone trabeculation (HP:0100670)3.56682898
9Oral leukoplakia (HP:0002745)3.47917495
10Macrocytic anemia (HP:0001972)3.46846369
11Mitochondrial inheritance (HP:0001427)3.41703791
12Aplastic anemia (HP:0001915)3.31968491
13Increased hepatocellular lipid droplets (HP:0006565)3.31741648
14Cerebral edema (HP:0002181)3.28856583
15Abnormality of glycolysis (HP:0004366)3.24823154
16Increased serum pyruvate (HP:0003542)3.24823154
17Carpal bone hypoplasia (HP:0001498)3.16533832
18Increased CSF lactate (HP:0002490)3.15175567
19Abnormal mitochondria in muscle tissue (HP:0008316)3.09554199
20Irregular epiphyses (HP:0010582)3.07538579
21Chromsome breakage (HP:0040012)2.95408543
22Patellar aplasia (HP:0006443)2.94882068
23Pallor (HP:0000980)2.94857513
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.92230685
25Hepatocellular necrosis (HP:0001404)2.90224505
26Progressive macrocephaly (HP:0004481)2.87706689
27Increased serum lactate (HP:0002151)2.85820168
28Abnormality of the preputium (HP:0100587)2.83394639
29Abnormality of the pons (HP:0007361)2.80837210
30Reduced antithrombin III activity (HP:0001976)2.79639800
31Methylmalonic acidemia (HP:0002912)2.78591950
323-Methylglutaconic aciduria (HP:0003535)2.77327302
33Premature graying of hair (HP:0002216)2.77164141
34Lipid accumulation in hepatocytes (HP:0006561)2.76790196
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.76503099
36Increased intramyocellular lipid droplets (HP:0012240)2.75738338
37Aplasia/Hypoplasia of the patella (HP:0006498)2.74778442
38Abnormal trabecular bone morphology (HP:0100671)2.71775635
39Methylmalonic aciduria (HP:0012120)2.67478230
40Abnormality of the labia minora (HP:0012880)2.67041038
41Acute encephalopathy (HP:0006846)2.65934386
42Abnormality of methionine metabolism (HP:0010901)2.65550022
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62969799
44Meckel diverticulum (HP:0002245)2.58978061
45Abnormality of chromosome stability (HP:0003220)2.58117729
46Absent radius (HP:0003974)2.53775419
47Hypoplasia of the pons (HP:0012110)2.50480107
48Absent thumb (HP:0009777)2.46638715
49Microvesicular hepatic steatosis (HP:0001414)2.46497673
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.45622081
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.45622081
52Abnormality of the anterior horn cell (HP:0006802)2.44453617
53Degeneration of anterior horn cells (HP:0002398)2.44453617
54Colon cancer (HP:0003003)2.44007510
55Secondary amenorrhea (HP:0000869)2.41441234
56Horseshoe kidney (HP:0000085)2.41229294
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40471029
58Abnormal protein N-linked glycosylation (HP:0012347)2.40471029
59Abnormal protein glycosylation (HP:0012346)2.40471029
60Abnormal glycosylation (HP:0012345)2.40471029
6111 pairs of ribs (HP:0000878)2.39724052
62CNS hypomyelination (HP:0003429)2.39557763
63Glossoptosis (HP:0000162)2.39503669
64Abnormality of the ileum (HP:0001549)2.39317372
65Abnormality of serum amino acid levels (HP:0003112)2.36120827
66Aplasia involving forearm bones (HP:0009822)2.35612255
67Absent forearm bone (HP:0003953)2.35612255
68Renal Fanconi syndrome (HP:0001994)2.33610828
69Exertional dyspnea (HP:0002875)2.33439444
70Hepatic necrosis (HP:0002605)2.30384728
71Impulsivity (HP:0100710)2.29190107
72Selective tooth agenesis (HP:0001592)2.27305882
73Supernumerary spleens (HP:0009799)2.27269805
74Pancytopenia (HP:0001876)2.26796444
75Hypoplasia of the capital femoral epiphysis (HP:0003090)2.24933781
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.24498228
77Exercise intolerance (HP:0003546)2.23860704
78Congenital, generalized hypertrichosis (HP:0004540)2.23447513
79Abnormal lung lobation (HP:0002101)2.22199756
80Bone marrow hypocellularity (HP:0005528)2.20898346
81Megaloblastic anemia (HP:0001889)2.20148765
82Type I transferrin isoform profile (HP:0003642)2.18492507
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.18102537
84Respiratory difficulties (HP:0002880)2.17489896
85Increased muscle lipid content (HP:0009058)2.17047371
86Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16825876
87Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15816154
88Cellular immunodeficiency (HP:0005374)2.14620855
89Hyperglycinemia (HP:0002154)2.14158286
90Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.12983381
91Absent epiphyses (HP:0010577)2.12983381
92Abnormality of renal resorption (HP:0011038)2.12792590
93Triphalangeal thumb (HP:0001199)2.11807411
94Lethargy (HP:0001254)2.11493525
95Duplicated collecting system (HP:0000081)2.08560849
96Agnosia (HP:0010524)2.04634579
97Optic disc pallor (HP:0000543)2.04235585
98Duodenal stenosis (HP:0100867)2.02966146
99Small intestinal stenosis (HP:0012848)2.02966146
100Respiratory failure (HP:0002878)2.02931660
101Postnatal microcephaly (HP:0005484)2.02315029
102Myelodysplasia (HP:0002863)2.00737652
103Cleft eyelid (HP:0000625)1.98035117
104Lactic acidosis (HP:0003128)1.95247252
105Microretrognathia (HP:0000308)1.94784629
106Premature ovarian failure (HP:0008209)1.94051492
107Medulloblastoma (HP:0002885)1.92965927
108Trismus (HP:0000211)1.91975211
109Sloping forehead (HP:0000340)1.91920791
110Neoplasm of the pancreas (HP:0002894)1.91157031
111Sparse eyelashes (HP:0000653)1.89123298
112Homocystinuria (HP:0002156)1.88436899
113Abnormality of homocysteine metabolism (HP:0010919)1.88436899
114Abnormality of the duodenum (HP:0002246)1.87647257
115Emotional lability (HP:0000712)1.86621521
116Hypoplasia of the radius (HP:0002984)1.84409089
117Type 2 muscle fiber atrophy (HP:0003554)1.84291736
118Nephroblastoma (Wilms tumor) (HP:0002667)1.83850048
119Leukodystrophy (HP:0002415)1.82905941
120Abnormality of the renal collecting system (HP:0004742)1.82756991
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82614076
122Abnormality of alanine metabolism (HP:0010916)1.82614076
123Hyperalaninemia (HP:0003348)1.82614076
124Multiple enchondromatosis (HP:0005701)1.81641794
125Pancreatic islet-cell hyperplasia (HP:0004510)1.81089938
126Stenosis of the external auditory canal (HP:0000402)1.80874912
127Embryonal renal neoplasm (HP:0011794)1.79131045
128Abnormality of placental membranes (HP:0011409)1.77435966
129Amniotic constriction ring (HP:0009775)1.77435966
130Neoplasm of the adrenal gland (HP:0100631)1.76740828
131Neoplasm of the colon (HP:0100273)1.75655634
132Abnormality of glycine metabolism (HP:0010895)1.70563693
133Abnormality of serine family amino acid metabolism (HP:0010894)1.70563693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.02787311
2EIF2AK14.37951635
3WEE14.26411329
4VRK23.38574097
5STK163.17208775
6SRPK12.99881836
7EIF2AK32.92571797
8CDC72.90645355
9TSSK62.57301096
10VRK12.47571866
11NME22.46925305
12MKNK12.38790732
13NUAK12.23571479
14BRSK22.18776453
15PLK42.13259212
16ACVR1B2.10141970
17MKNK22.05609346
18PBK2.01599027
19MST41.94037514
20PLK31.93167345
21TAF11.90512628
22NME11.81228508
23PLK11.76374934
24TLK11.66493014
25TTK1.64260113
26TRIM281.61689245
27TESK21.60757607
28PNCK1.60677568
29NEK11.51381345
30NEK21.44659876
31AURKB1.43165697
32DYRK31.35502098
33ATR1.27272367
34CCNB11.25661016
35AURKA1.21828373
36BRSK11.19428255
37ZAK1.17287901
38CDK71.16798135
39EIF2AK21.12841550
40CHEK21.10082508
41INSRR1.04093140
42PIM21.00202961
43RPS6KB20.97649728
44CHEK10.93549215
45MAP3K120.91897309
46RPS6KA40.91675592
47CDK80.89866828
48EPHA20.85838901
49CSNK2A20.85472307
50PASK0.84507895
51DYRK20.82716510
52CSNK2A10.81125990
53STK30.79856439
54BRAF0.74917554
55BCR0.73723290
56MAP4K20.71745367
57LATS10.69827554
58ATM0.68181327
59MAP3K80.67804490
60LIMK10.67463145
61BMPR1B0.67384076
62STK390.65635434
63BCKDK0.64339625
64PAK10.61309195
65RPS6KA50.60968959
66TNIK0.60175245
67STK40.60092451
68MAPKAPK50.59913386
69CDK20.58344332
70ADRBK20.58013117
71GRK10.56321904
72PDK30.56312630
73PDK40.56312630
74PRKCI0.55234481
75TGFBR10.54757788
76CDK10.52277802
77NEK60.51901566
78CDK40.50505463
79CSNK1G30.49983070
80ABL20.48505252
81PAK40.48078168
82OXSR10.47767407
83MELK0.45497045
84ERBB40.44418213
85CASK0.43568122
86YES10.42687430
87CSNK1G20.42617791
88FGFR10.41397989
89PDK20.40833982
90PIM10.38916510
91WNK40.38258018
92CDK190.37349853
93PLK20.37285283
94CSNK1E0.36619443
95DAPK10.36197517
96STK38L0.34929900
97AKT30.34572815
98TXK0.33862010
99CSNK1A1L0.33523989
100TESK10.32901184
101CLK10.31605074
102FRK0.31535948
103MAP3K110.29568579
104TEC0.29465988
105WNK30.29256206
106STK240.28954581
107IRAK40.28681017
108NLK0.28279728
109STK100.28102192
110CDK11A0.28047776
111KDR0.27954429
112CDK180.27232962
113ERBB30.26486970
114MAP3K40.26335356
115CDK140.26175034
116CSNK1G10.25968703
117MAPKAPK30.25882291
118CDK150.24361957
119TAOK20.24107141
120SCYL20.23029319
121PRKCG0.22225396
122PRKDC0.21857416
123OBSCN0.20828922
124CSNK1A10.20703484
125CDK90.20625830
126IRAK30.20608063
127ALK0.19813602
128ILK0.18825581

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.61989573
2Ribosome_Homo sapiens_hsa030104.40500385
3RNA polymerase_Homo sapiens_hsa030204.31787776
4DNA replication_Homo sapiens_hsa030304.07686015
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.04553862
6Mismatch repair_Homo sapiens_hsa034303.69689944
7Spliceosome_Homo sapiens_hsa030403.29335460
8RNA transport_Homo sapiens_hsa030132.98126181
9Nucleotide excision repair_Homo sapiens_hsa034202.84680305
10Homologous recombination_Homo sapiens_hsa034402.80071213
11Pyrimidine metabolism_Homo sapiens_hsa002402.70509626
12Base excision repair_Homo sapiens_hsa034102.41899080
13Basal transcription factors_Homo sapiens_hsa030222.28650972
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21499741
15Cell cycle_Homo sapiens_hsa041102.16255465
16Oxidative phosphorylation_Homo sapiens_hsa001902.10753673
17Non-homologous end-joining_Homo sapiens_hsa034502.07496242
18Fanconi anemia pathway_Homo sapiens_hsa034602.04578525
19Protein export_Homo sapiens_hsa030602.01757622
20One carbon pool by folate_Homo sapiens_hsa006702.00968645
21Parkinsons disease_Homo sapiens_hsa050121.94396179
22RNA degradation_Homo sapiens_hsa030181.88042579
23Huntingtons disease_Homo sapiens_hsa050161.71079034
24Purine metabolism_Homo sapiens_hsa002301.62150732
25Propanoate metabolism_Homo sapiens_hsa006401.59789080
26mRNA surveillance pathway_Homo sapiens_hsa030151.35824852
27Vitamin B6 metabolism_Homo sapiens_hsa007501.33094248
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31735718
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19787546
30Epstein-Barr virus infection_Homo sapiens_hsa051691.19706473
31p53 signaling pathway_Homo sapiens_hsa041151.15664715
32Alzheimers disease_Homo sapiens_hsa050101.14376115
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13501866
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08210380
35Systemic lupus erythematosus_Homo sapiens_hsa053220.94285881
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92727767
37Oocyte meiosis_Homo sapiens_hsa041140.88870204
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88499086
39Sulfur metabolism_Homo sapiens_hsa009200.84847049
40Folate biosynthesis_Homo sapiens_hsa007900.80792576
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78987763
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.78101432
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77148325
44Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72621469
45Pentose phosphate pathway_Homo sapiens_hsa000300.68002653
46Antigen processing and presentation_Homo sapiens_hsa046120.67932757
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66192285
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59859059
49Glutathione metabolism_Homo sapiens_hsa004800.56369319
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55702337
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54203404
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53602600
53Viral carcinogenesis_Homo sapiens_hsa052030.53560390
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.52982315
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52734646
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52436755
57Butanoate metabolism_Homo sapiens_hsa006500.52083042
58Biosynthesis of amino acids_Homo sapiens_hsa012300.50632858
59Peroxisome_Homo sapiens_hsa041460.49847394
60Herpes simplex infection_Homo sapiens_hsa051680.48323899
61Metabolic pathways_Homo sapiens_hsa011000.47667531
62Tryptophan metabolism_Homo sapiens_hsa003800.44976791
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.43810558
64Fatty acid metabolism_Homo sapiens_hsa012120.42495473
65Fatty acid degradation_Homo sapiens_hsa000710.42033126
66Sulfur relay system_Homo sapiens_hsa041220.41855501
67Caffeine metabolism_Homo sapiens_hsa002320.41746126
68Regulation of autophagy_Homo sapiens_hsa041400.41370537
69Cardiac muscle contraction_Homo sapiens_hsa042600.41211702
70Alcoholism_Homo sapiens_hsa050340.40070357
71beta-Alanine metabolism_Homo sapiens_hsa004100.38849201
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38577272
73Arachidonic acid metabolism_Homo sapiens_hsa005900.37258413
74Primary immunodeficiency_Homo sapiens_hsa053400.37064607
75Allograft rejection_Homo sapiens_hsa053300.36284241
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35851850
77Vitamin digestion and absorption_Homo sapiens_hsa049770.35750870
78Retinol metabolism_Homo sapiens_hsa008300.35148273
79Graft-versus-host disease_Homo sapiens_hsa053320.33367076
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32759884
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31279433
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.31050958
83Chemical carcinogenesis_Homo sapiens_hsa052040.29484533
84Carbon metabolism_Homo sapiens_hsa012000.27306811
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26354976
86HTLV-I infection_Homo sapiens_hsa051660.25487861
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25380166
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23779911
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.23114808
90N-Glycan biosynthesis_Homo sapiens_hsa005100.22771795
91Selenocompound metabolism_Homo sapiens_hsa004500.21465933
92Legionellosis_Homo sapiens_hsa051340.20942647
93Asthma_Homo sapiens_hsa053100.20823364
94Type I diabetes mellitus_Homo sapiens_hsa049400.20575526
95Tyrosine metabolism_Homo sapiens_hsa003500.19574633
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.19415714
97Nitrogen metabolism_Homo sapiens_hsa009100.19247558
98Autoimmune thyroid disease_Homo sapiens_hsa053200.17241087
99Thyroid cancer_Homo sapiens_hsa052160.17180395
100Steroid biosynthesis_Homo sapiens_hsa001000.17163444
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14978594
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14692544
103Fructose and mannose metabolism_Homo sapiens_hsa000510.14662462
104Sphingolipid metabolism_Homo sapiens_hsa006000.12361920
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11395146
106Arginine and proline metabolism_Homo sapiens_hsa003300.10931120
107TGF-beta signaling pathway_Homo sapiens_hsa043500.10848368
108Hematopoietic cell lineage_Homo sapiens_hsa046400.09493861
109Vibrio cholerae infection_Homo sapiens_hsa051100.09197298
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08774099
111Fatty acid elongation_Homo sapiens_hsa000620.08626228
112Renin-angiotensin system_Homo sapiens_hsa046140.07885692
113Linoleic acid metabolism_Homo sapiens_hsa005910.07801393
114Shigellosis_Homo sapiens_hsa051310.07757996
115Mineral absorption_Homo sapiens_hsa049780.07451916
116Fat digestion and absorption_Homo sapiens_hsa049750.07399413
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.07054180
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.07019110
119Arginine biosynthesis_Homo sapiens_hsa002200.06841559
120Ether lipid metabolism_Homo sapiens_hsa005650.06047046
121Starch and sucrose metabolism_Homo sapiens_hsa005000.05592296
122Collecting duct acid secretion_Homo sapiens_hsa049660.05368281
123Phototransduction_Homo sapiens_hsa047440.04978896
124Measles_Homo sapiens_hsa051620.04806569
125MicroRNAs in cancer_Homo sapiens_hsa052060.04689641
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03613403
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.02434878
128Pyruvate metabolism_Homo sapiens_hsa006200.02225768
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072-0.0224885
130Transcriptional misregulation in cancer_Homo sapiens_hsa05202-0.0091429
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532-0.0058185
132NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0050427

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