RPGRIP1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene can localize to the basal body-centrosome complex or to primary cilia and centrosomes in ciliated cells. The encoded protein has been found to interact with nephrocystin-4. Defects in this gene are a cause of Joubert syndrome type 7 (JBTS7) and Meckel syndrome type 5 (MKS5). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.33758392
2cilium movement (GO:0003341)4.42656202
3behavioral response to nicotine (GO:0035095)4.41308332
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.05518793
5axonemal dynein complex assembly (GO:0070286)3.98912335
6neuron cell-cell adhesion (GO:0007158)3.93110940
7epithelial cilium movement (GO:0003351)3.90693482
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.85325354
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.85149514
10ionotropic glutamate receptor signaling pathway (GO:0035235)3.79330231
11vocalization behavior (GO:0071625)3.78512441
12protein localization to synapse (GO:0035418)3.66560997
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.64081235
14DNA double-strand break processing (GO:0000729)3.56165250
15protein localization to cilium (GO:0061512)3.55878134
16regulation of glutamate receptor signaling pathway (GO:1900449)3.50355091
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.49405791
18synaptic vesicle exocytosis (GO:0016079)3.45021037
19intraciliary transport (GO:0042073)3.44611107
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.44533113
21synaptic vesicle docking involved in exocytosis (GO:0016081)3.44356768
22ventricular system development (GO:0021591)3.43817654
23glutamate receptor signaling pathway (GO:0007215)3.42816960
24nonmotile primary cilium assembly (GO:0035058)3.38217377
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34227251
26synaptic transmission, glutamatergic (GO:0035249)3.33633208
27presynaptic membrane assembly (GO:0097105)3.33139611
28cilium morphogenesis (GO:0060271)3.32262942
29startle response (GO:0001964)3.31105894
30cerebellar Purkinje cell differentiation (GO:0021702)3.27983762
31protein polyglutamylation (GO:0018095)3.27360535
32axonal fasciculation (GO:0007413)3.21871728
33synaptic vesicle endocytosis (GO:0048488)3.21387368
34response to pheromone (GO:0019236)3.21250553
35neuron-neuron synaptic transmission (GO:0007270)3.16968734
36presynaptic membrane organization (GO:0097090)3.13076543
37motile cilium assembly (GO:0044458)3.08660400
38regulation of synaptic vesicle exocytosis (GO:2000300)3.07977672
39pyrimidine nucleobase catabolic process (GO:0006208)3.07692879
40neuron recognition (GO:0008038)3.06134218
41glutamate secretion (GO:0014047)3.05771211
42cerebral cortex radially oriented cell migration (GO:0021799)3.05640455
43water-soluble vitamin biosynthetic process (GO:0042364)3.03648774
44centriole replication (GO:0007099)3.02874799
45acrosome assembly (GO:0001675)3.02110606
46locomotory exploration behavior (GO:0035641)3.01267503
47acrosome reaction (GO:0007340)3.00724950
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99093711
49negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95417946
50regulation of long-term neuronal synaptic plasticity (GO:0048169)2.93618078
51calcium ion-dependent exocytosis (GO:0017156)2.90827995
52gamma-aminobutyric acid signaling pathway (GO:0007214)2.87959278
53synaptic vesicle maturation (GO:0016188)2.86865341
54neural tube formation (GO:0001841)2.85604039
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83103540
56transmission of nerve impulse (GO:0019226)2.82990955
57negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82726260
58replication fork processing (GO:0031297)2.82114199
59male meiosis (GO:0007140)2.81044977
60multicellular organism reproduction (GO:0032504)2.78822910
61neuronal ion channel clustering (GO:0045161)2.77867720
62gamma-aminobutyric acid transport (GO:0015812)2.77371287
63regulation of synaptic vesicle transport (GO:1902803)2.74199470
64layer formation in cerebral cortex (GO:0021819)2.73914217
65central nervous system projection neuron axonogenesis (GO:0021952)2.73356477
66fusion of sperm to egg plasma membrane (GO:0007342)2.71870373
67regulation of neuronal synaptic plasticity (GO:0048168)2.70804648
68exploration behavior (GO:0035640)2.70722454
69righting reflex (GO:0060013)2.68688651
70resolution of meiotic recombination intermediates (GO:0000712)2.68586763
71membrane depolarization during action potential (GO:0086010)2.68331634
72regulation of dendritic spine morphogenesis (GO:0061001)2.68144993
73appendage development (GO:0048736)2.67530347
74limb development (GO:0060173)2.67530347
75retinal ganglion cell axon guidance (GO:0031290)2.66608070
76piRNA metabolic process (GO:0034587)2.66220873
77regulation of excitatory postsynaptic membrane potential (GO:0060079)2.66133557
78postsynaptic membrane organization (GO:0001941)2.65624559
79regulation of DNA endoreduplication (GO:0032875)2.65481546
80vesicle transport along microtubule (GO:0047496)2.64678538
81protein complex biogenesis (GO:0070271)2.63942113
82long-term synaptic potentiation (GO:0060291)2.62987723
83positive regulation of dendritic spine morphogenesis (GO:0061003)2.62655807
84regulation of postsynaptic membrane potential (GO:0060078)2.61645195
85neuronal action potential propagation (GO:0019227)2.60636022
86smoothened signaling pathway (GO:0007224)2.58902008
87regulation of synaptic transmission, glutamatergic (GO:0051966)2.58609476
88response to histamine (GO:0034776)2.58602445
89* cellular component assembly involved in morphogenesis (GO:0010927)2.58249695
90* cilium organization (GO:0044782)2.57893045
91regulation of meiosis I (GO:0060631)2.55989845
92response to auditory stimulus (GO:0010996)2.55584538
93mitochondrial respiratory chain complex I assembly (GO:0032981)2.55569697
94NADH dehydrogenase complex assembly (GO:0010257)2.55569697
95mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55569697
96dendrite morphogenesis (GO:0048813)2.55400287
97sperm motility (GO:0030317)2.55075348
98* cilium assembly (GO:0042384)2.54595185
99mitochondrial respiratory chain complex assembly (GO:0033108)2.54552450
100photoreceptor cell maintenance (GO:0045494)2.53858317
101respiratory chain complex IV assembly (GO:0008535)2.53482194
102regulation of neurotransmitter secretion (GO:0046928)2.53290087
103nucleobase catabolic process (GO:0046113)2.53165926
104positive regulation of neurotransmitter secretion (GO:0001956)2.52800082
105negative regulation of astrocyte differentiation (GO:0048712)2.52124159
106regulation of cilium movement (GO:0003352)2.52063715
107cornea development in camera-type eye (GO:0061303)2.51004817
108positive regulation of neurotransmitter transport (GO:0051590)2.50567243
109regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.50466214
110negative regulation of DNA-dependent DNA replication (GO:2000104)2.50452639
111axoneme assembly (GO:0035082)2.49603990
112limb bud formation (GO:0060174)2.49384998
113regulation of synaptic transmission, GABAergic (GO:0032228)2.48933807
114peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.48760222
115synapse assembly (GO:0007416)2.48547977
116membrane hyperpolarization (GO:0060081)2.47862509
117behavioral fear response (GO:0001662)2.47828869
118behavioral defense response (GO:0002209)2.47828869
119left/right axis specification (GO:0070986)2.47385241
120protein-cofactor linkage (GO:0018065)2.46999719
121inner ear receptor stereocilium organization (GO:0060122)2.46948479
122dendrite development (GO:0016358)2.46914150
123regulation of collateral sprouting (GO:0048670)2.46892819
124neurotransmitter secretion (GO:0007269)2.45836430
125long-term memory (GO:0007616)2.45634819
126microtubule severing (GO:0051013)2.45486981
127positive regulation of membrane potential (GO:0045838)2.44498157
128dendritic spine morphogenesis (GO:0060997)2.44474540
129regulation of microtubule-based movement (GO:0060632)2.43915665
130proline transport (GO:0015824)2.43536792
131plasma membrane fusion (GO:0045026)2.42321367
132recombinational repair (GO:0000725)2.42288896
133learning (GO:0007612)2.40881345
134membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40817710
135innervation (GO:0060384)2.39721277
136auditory behavior (GO:0031223)2.39569600
137double-strand break repair via homologous recombination (GO:0000724)2.39525998
138regulation of synaptic plasticity (GO:0048167)2.39135657
139reflex (GO:0060004)2.38397266
140somite development (GO:0061053)2.36007656
141synapsis (GO:0007129)2.35959575
142kidney morphogenesis (GO:0060993)2.35823631
143behavioral response to ethanol (GO:0048149)2.35154026
144preassembly of GPI anchor in ER membrane (GO:0016254)2.34655980
145* determination of left/right symmetry (GO:0007368)2.32524849
146protein K11-linked deubiquitination (GO:0035871)2.32163994
147regulation of hippo signaling (GO:0035330)2.31935998
148hindbrain development (GO:0030902)2.31211994
149reciprocal meiotic recombination (GO:0007131)2.30710781
150reciprocal DNA recombination (GO:0035825)2.30710781
151spinal cord motor neuron differentiation (GO:0021522)2.30456082
152microtubule bundle formation (GO:0001578)2.29540494
153establishment of protein localization to mitochondrial membrane (GO:0090151)2.28283097
154fucose catabolic process (GO:0019317)2.25710281
155L-fucose metabolic process (GO:0042354)2.25710281
156L-fucose catabolic process (GO:0042355)2.25710281
157indolalkylamine metabolic process (GO:0006586)2.24212653
158mannosylation (GO:0097502)2.22878900
159left/right pattern formation (GO:0060972)2.22470736
160negative regulation of transcription regulatory region DNA binding (GO:2000678)2.21687742
161cell proliferation in forebrain (GO:0021846)2.20478011
162photoreceptor cell development (GO:0042461)2.20396032
163* determination of bilateral symmetry (GO:0009855)2.20200879
164detection of light stimulus involved in sensory perception (GO:0050962)2.19589966
165detection of light stimulus involved in visual perception (GO:0050908)2.19589966
166somatic diversification of immune receptors via somatic mutation (GO:0002566)2.19362773
167somatic hypermutation of immunoglobulin genes (GO:0016446)2.19362773
168centriole assembly (GO:0098534)2.19029165
169mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.18755129
170retinal cone cell development (GO:0046549)2.18452295
171cellular ketone body metabolic process (GO:0046950)2.18334655
172spinal cord development (GO:0021510)2.18255591
173cytochrome complex assembly (GO:0017004)2.15272047
174regulation of glucokinase activity (GO:0033131)2.14848644
175regulation of hexokinase activity (GO:1903299)2.14848644

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.04222629
2GBX2_23144817_ChIP-Seq_PC3_Human4.15733424
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61173363
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49236342
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45227043
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29043441
7TAF15_26573619_Chip-Seq_HEK293_Human2.24822138
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12357124
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.12115908
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09368768
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06944797
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04916964
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.02456498
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00845358
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95899768
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95603182
17FUS_26573619_Chip-Seq_HEK293_Human1.92794257
18P300_19829295_ChIP-Seq_ESCs_Human1.91818403
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91805055
20SMAD4_21799915_ChIP-Seq_A2780_Human1.90393344
21* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87649369
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.83054820
23IGF1R_20145208_ChIP-Seq_DFB_Human1.82509822
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80580915
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80460250
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.78981379
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78926413
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78926413
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77431807
30DROSHA_22980978_ChIP-Seq_HELA_Human1.77314736
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76002313
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.75230047
33RNF2_27304074_Chip-Seq_NSC_Mouse1.74872958
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.74759284
35REST_21632747_ChIP-Seq_MESCs_Mouse1.73537406
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71278912
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69843265
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69435921
39* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68984785
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.65531155
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64425506
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.61175823
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60490328
44STAT3_23295773_ChIP-Seq_U87_Human1.59719121
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58536106
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58045689
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57621012
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57594065
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.56600784
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.56436018
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.54631345
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.54338303
53EWS_26573619_Chip-Seq_HEK293_Human1.54293510
54SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53401794
55AR_21572438_ChIP-Seq_LNCaP_Human1.53221134
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51789040
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51569458
58IRF1_19129219_ChIP-ChIP_H3396_Human1.50250793
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49320038
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48246554
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.47115522
62ELK1_19687146_ChIP-ChIP_HELA_Human1.46539105
63CBP_20019798_ChIP-Seq_JUKART_Human1.46460829
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46460829
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44981889
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.44596405
67ER_23166858_ChIP-Seq_MCF-7_Human1.43732026
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.43718535
69VDR_22108803_ChIP-Seq_LS180_Human1.43373143
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43022225
71* TCF4_23295773_ChIP-Seq_U87_Human1.42740457
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42326846
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42121167
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41882041
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41745346
76AR_25329375_ChIP-Seq_VCAP_Human1.39988050
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39371611
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39018132
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39018132
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38721376
81MYC_18940864_ChIP-ChIP_HL60_Human1.37865710
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.37809861
83BCAT_22108803_ChIP-Seq_LS180_Human1.36575644
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36434516
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35778772
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33304067
87ZNF274_21170338_ChIP-Seq_K562_Hela1.32559975
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31616597
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30142230
90P53_22387025_ChIP-Seq_ESCs_Mouse1.29869735
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.29369309
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29351104
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27695013
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26757836
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23902759
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23520162
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23039365
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.23021276
99TP53_22573176_ChIP-Seq_HFKS_Human1.22298321
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20942498
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20232764
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19952956
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19693122
104RUNX2_22187159_ChIP-Seq_PCA_Human1.19420300
105TCF4_22108803_ChIP-Seq_LS180_Human1.19417335
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.19003042
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18745050
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18359749
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18253953
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17937174
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17605927
112SOX2_21211035_ChIP-Seq_LN229_Gbm1.17298053
113EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16621476
114RARB_27405468_Chip-Seq_BRAIN_Mouse1.15057127
115TP53_16413492_ChIP-PET_HCT116_Human1.14114301
116KDM2B_26808549_Chip-Seq_REH_Human1.12853268
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11253500
118P300_18555785_Chip-Seq_ESCs_Mouse1.11152473
119SOX2_18555785_Chip-Seq_ESCs_Mouse1.11107984
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.10989160
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10524393
122JUN_21703547_ChIP-Seq_K562_Human1.07508908
123TP63_19390658_ChIP-ChIP_HaCaT_Human1.07409481
124NANOG_19829295_ChIP-Seq_ESCs_Human1.06667465
125SOX2_19829295_ChIP-Seq_ESCs_Human1.06667465
126SMAD4_21741376_ChIP-Seq_EPCs_Human1.06083874
127PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05021673
128FLI1_21867929_ChIP-Seq_TH2_Mouse1.02523202
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99913321
130FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97576807
131FOXA1_25329375_ChIP-Seq_VCAP_Human0.97576807
132E2F4_17652178_ChIP-ChIP_JURKAT_Human0.96766083
133TAL1_26923725_Chip-Seq_HPCs_Mouse0.94001048
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.93401244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.17614558
2MP0003880_abnormal_central_pattern3.71117374
3MP0003635_abnormal_synaptic_transmissio2.83258898
4MP0009046_muscle_twitch2.77622112
5MP0004270_analgesia2.52425689
6MP0005645_abnormal_hypothalamus_physiol2.45214200
7MP0009745_abnormal_behavioral_response2.42934420
8MP0002063_abnormal_learning/memory/cond2.30805334
9MP0001486_abnormal_startle_reflex2.29386908
10MP0000569_abnormal_digit_pigmentation2.28562665
11MP0005423_abnormal_somatic_nervous2.27863884
12MP0005410_abnormal_fertilization2.26815853
13MP0001984_abnormal_olfaction2.24769588
14MP0002572_abnormal_emotion/affect_behav2.22648935
15MP0001968_abnormal_touch/_nociception2.21857855
16MP0003787_abnormal_imprinting2.20762901
17MP0002064_seizures2.17840934
18MP0005646_abnormal_pituitary_gland2.11824136
19MP0002734_abnormal_mechanical_nocicepti2.09372381
20* MP0000778_abnormal_nervous_system1.94355738
21MP0005171_absent_coat_pigmentation1.88562199
22MP0002272_abnormal_nervous_system1.86600066
23MP0001188_hyperpigmentation1.83287232
24* MP0004133_heterotaxia1.79299486
25MP0002735_abnormal_chemical_nociception1.79048209
26MP0002736_abnormal_nociception_after1.78447265
27MP0003122_maternal_imprinting1.75391893
28MP0002557_abnormal_social/conspecific_i1.74493291
29MP0008877_abnormal_DNA_methylation1.74438438
30MP0006072_abnormal_retinal_apoptosis1.73745154
31MP0006292_abnormal_olfactory_placode1.73065103
32MP0006276_abnormal_autonomic_nervous1.72382901
33MP0001440_abnormal_grooming_behavior1.69550770
34MP0002160_abnormal_reproductive_system1.67004286
35MP0003890_abnormal_embryonic-extraembry1.63872148
36MP0002067_abnormal_sensory_capabilities1.62410427
37MP0002184_abnormal_innervation1.60273756
38* MP0003937_abnormal_limbs/digits/tail_de1.57984161
39MP0003121_genomic_imprinting1.49580816
40MP0001501_abnormal_sleep_pattern1.48420747
41MP0004924_abnormal_behavior1.48322016
42MP0005386_behavior/neurological_phenoty1.48322016
43MP0000372_irregular_coat_pigmentation1.47160718
44MP0001529_abnormal_vocalization1.46444054
45MP0008058_abnormal_DNA_repair1.46023338
46MP0004742_abnormal_vestibular_system1.39536042
47* MP0001293_anophthalmia1.38785779
48MP0003698_abnormal_male_reproductive1.38251419
49MP0002234_abnormal_pharynx_morphology1.37639185
50MP0000566_synostosis1.36345083
51MP0000427_abnormal_hair_cycle1.35018287
52MP0005623_abnormal_meninges_morphology1.33974333
53MP0005551_abnormal_eye_electrophysiolog1.32037492
54MP0004142_abnormal_muscle_tone1.31632229
55MP0004811_abnormal_neuron_physiology1.31593093
56* MP0000631_abnormal_neuroendocrine_gland1.31530245
57MP0001485_abnormal_pinna_reflex1.26679705
58MP0003718_maternal_effect1.24908418
59MP0002882_abnormal_neuron_morphology1.24551918
60MP0001970_abnormal_pain_threshold1.24282048
61MP0000383_abnormal_hair_follicle1.22798391
62MP0003119_abnormal_digestive_system1.21086408
63MP0004885_abnormal_endolymph1.20933917
64MP0002837_dystrophic_cardiac_calcinosis1.17840504
65MP0008004_abnormal_stomach_pH1.15783674
66MP0000647_abnormal_sebaceous_gland1.15268823
67MP0005499_abnormal_olfactory_system1.14904161
68MP0005394_taste/olfaction_phenotype1.14904161
69MP0003879_abnormal_hair_cell1.14375440
70MP0000955_abnormal_spinal_cord1.14347562
71MP0005389_reproductive_system_phenotype1.12461288
72MP0005195_abnormal_posterior_eye1.12422312
73MP0002102_abnormal_ear_morphology1.12346016
74MP0002938_white_spotting1.11377594
75MP0002733_abnormal_thermal_nociception1.11081564
76MP0002751_abnormal_autonomic_nervous1.10823937
77MP0003195_calcinosis1.09741697
78MP0001299_abnormal_eye_distance/1.06263154
79* MP0002152_abnormal_brain_morphology1.04247686
80MP0005409_darkened_coat_color1.04057414
81MP0010030_abnormal_orbit_morphology1.03107529
82MP0008872_abnormal_physiological_respon1.03045573
83MP0001286_abnormal_eye_development1.02765704
84MP0003950_abnormal_plasma_membrane1.02100014
85MP0001346_abnormal_lacrimal_gland1.01750551
86MP0008875_abnormal_xenobiotic_pharmacok1.01459276
87MP0001963_abnormal_hearing_physiology0.99348348
88MP0004043_abnormal_pH_regulation0.99347112
89MP0009697_abnormal_copulation0.99341937
90MP0001929_abnormal_gametogenesis0.98211166
91MP0005503_abnormal_tendon_morphology0.98135659
92MP0001177_atelectasis0.97869823
93MP0002653_abnormal_ependyma_morphology0.96992083
94MP0002066_abnormal_motor_capabilities/c0.95920285
95MP0010094_abnormal_chromosome_stability0.95428467
96MP0008569_lethality_at_weaning0.95418088
97MP0003567_abnormal_fetal_cardiomyocyte0.94263009
98MP0002876_abnormal_thyroid_physiology0.93461811
99MP0002752_abnormal_somatic_nervous0.93404114
100MP0008789_abnormal_olfactory_epithelium0.93366662
101MP0009250_abnormal_appendicular_skeleto0.93045628
102MP0002210_abnormal_sex_determination0.91473818
103MP0003136_yellow_coat_color0.90683093
104* MP0005391_vision/eye_phenotype0.90551628
105MP0002233_abnormal_nose_morphology0.90434096
106MP0003878_abnormal_ear_physiology0.89828374
107MP0005377_hearing/vestibular/ear_phenot0.89828374
108MP0000534_abnormal_ureter_morphology0.89618389
109MP0001905_abnormal_dopamine_level0.89428531
110MP0001502_abnormal_circadian_rhythm0.89423342
111MP0003755_abnormal_palate_morphology0.88628018
112MP0003385_abnormal_body_wall0.86772647
113* MP0003861_abnormal_nervous_system0.86308529
114MP0003646_muscle_fatigue0.86232308
115MP0003938_abnormal_ear_development0.85855274
116MP0005187_abnormal_penis_morphology0.84788258
117MP0001324_abnormal_eye_pigmentation0.84754178
118MP0000678_abnormal_parathyroid_gland0.84562808
119MP0000516_abnormal_urinary_system0.83287903
120MP0005367_renal/urinary_system_phenotyp0.83287903
121MP0000049_abnormal_middle_ear0.83037054
122MP0009780_abnormal_chondrocyte_physiolo0.82775177
123MP0005248_abnormal_Harderian_gland0.79891806
124MP0002822_catalepsy0.79801824
125MP0000026_abnormal_inner_ear0.79346371
126MP0010386_abnormal_urinary_bladder0.77740396
127MP0002638_abnormal_pupillary_reflex0.77681518
128MP0000015_abnormal_ear_pigmentation0.76124819
129MP0005253_abnormal_eye_physiology0.75566543
130MP0002177_abnormal_outer_ear0.74299372
131MP0003942_abnormal_urinary_system0.73844127
132MP0001986_abnormal_taste_sensitivity0.73809496
133MP0002249_abnormal_larynx_morphology0.73805488

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)5.60308360
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.60308360
3Abnormal ciliary motility (HP:0012262)5.57709733
4Abnormal respiratory motile cilium physiology (HP:0012261)5.38259028
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.37093821
6Abnormal respiratory epithelium morphology (HP:0012253)4.60397484
7Abnormal respiratory motile cilium morphology (HP:0005938)4.60397484
8Focal motor seizures (HP:0011153)4.46774578
9Rhinitis (HP:0012384)3.96355833
10* Pancreatic cysts (HP:0001737)3.83497909
11Febrile seizures (HP:0002373)3.37710718
12Epileptic encephalopathy (HP:0200134)3.29983286
13Focal seizures (HP:0007359)3.09130159
14Medial flaring of the eyebrow (HP:0010747)2.98867977
15Gait imbalance (HP:0002141)2.91458475
16* Chronic hepatic failure (HP:0100626)2.83311175
17Abnormality of the renal cortex (HP:0011035)2.73204471
18Atonic seizures (HP:0010819)2.72663836
19Congenital primary aphakia (HP:0007707)2.68166711
20* Nephronophthisis (HP:0000090)2.65503361
21Nephrogenic diabetes insipidus (HP:0009806)2.58514860
22Progressive cerebellar ataxia (HP:0002073)2.54298607
23Genital tract atresia (HP:0001827)2.54103434
24* Cystic liver disease (HP:0006706)2.53132457
25Tubulointerstitial nephritis (HP:0001970)2.50329442
26Vaginal atresia (HP:0000148)2.47758158
27Absent eyebrow (HP:0002223)2.46681804
28Aplasia/Hypoplasia of the tibia (HP:0005772)2.40053926
29Type II lissencephaly (HP:0007260)2.39958587
30Myokymia (HP:0002411)2.38701101
31Absent speech (HP:0001344)2.38197476
32* Molar tooth sign on MRI (HP:0002419)2.36940114
33* Abnormality of midbrain morphology (HP:0002418)2.36940114
34* Abnormality of the renal medulla (HP:0100957)2.34041261
35Tubular atrophy (HP:0000092)2.31759611
36* Sclerocornea (HP:0000647)2.31582602
37Intestinal atresia (HP:0011100)2.27789586
38* Pancreatic fibrosis (HP:0100732)2.26236805
39Protruding tongue (HP:0010808)2.22887381
40* True hermaphroditism (HP:0010459)2.22646793
41Widely spaced teeth (HP:0000687)2.22497734
42Congenital stationary night blindness (HP:0007642)2.22494676
43* Anencephaly (HP:0002323)2.21499107
44Hyperventilation (HP:0002883)2.19954801
45Broad-based gait (HP:0002136)2.18168568
46Renal dysplasia (HP:0000110)2.15616714
47Gaze-evoked nystagmus (HP:0000640)2.15054935
48Excessive salivation (HP:0003781)2.14326654
49Drooling (HP:0002307)2.14326654
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13648059
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.13648059
52Oligodactyly (hands) (HP:0001180)2.12890714
53Supernumerary spleens (HP:0009799)2.10678207
54Papillary thyroid carcinoma (HP:0002895)2.10205752
55Poor coordination (HP:0002370)2.09534157
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.08599397
57Pendular nystagmus (HP:0012043)2.08574175
58Colon cancer (HP:0003003)2.06570485
59Absence seizures (HP:0002121)2.05443340
60Short tibia (HP:0005736)2.04752730
61Urinary bladder sphincter dysfunction (HP:0002839)2.04313273
62Abnormality of incisor morphology (HP:0011063)2.03987760
63Impaired vibration sensation in the lower limbs (HP:0002166)2.02918691
64* Male pseudohermaphroditism (HP:0000037)2.02110015
65Midline defect of the nose (HP:0004122)1.99728789
66Abnormality of the corticospinal tract (HP:0002492)1.98601341
67* Postaxial hand polydactyly (HP:0001162)1.95900734
68Cutaneous finger syndactyly (HP:0010554)1.95735891
69Microglossia (HP:0000171)1.95592166
70Abolished electroretinogram (ERG) (HP:0000550)1.94334358
71Optic nerve hypoplasia (HP:0000609)1.92332972
72Lissencephaly (HP:0001339)1.92119149
73Dialeptic seizures (HP:0011146)1.92051253
74Renal cortical cysts (HP:0000803)1.91705919
75Abnormal drinking behavior (HP:0030082)1.91252917
76Polydipsia (HP:0001959)1.91252917
77Blue irides (HP:0000635)1.90120395
78Bronchiectasis (HP:0002110)1.89979386
79* Aplasia/Hypoplasia of the tongue (HP:0010295)1.89683268
80Cerebellar dysplasia (HP:0007033)1.88449231
81Abnormal hair whorl (HP:0010721)1.87455359
82Aplasia/Hypoplasia of the lens (HP:0008063)1.85622852
83Chronic sinusitis (HP:0011109)1.84671706
84* Occipital encephalocele (HP:0002085)1.84517844
85Methylmalonic acidemia (HP:0002912)1.84350504
86Hyperglycinemia (HP:0002154)1.84154648
87Anophthalmia (HP:0000528)1.81060536
88Progressive inability to walk (HP:0002505)1.80973121
89Abnormality of alanine metabolism (HP:0010916)1.80184618
90Hyperalaninemia (HP:0003348)1.80184618
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80184618
92Inability to walk (HP:0002540)1.79715724
93Generalized tonic-clonic seizures (HP:0002069)1.79382604
94* Furrowed tongue (HP:0000221)1.79251760
95Infertility (HP:0000789)1.78697737
96Small hand (HP:0200055)1.77516657
97Chronic bronchitis (HP:0004469)1.77372121
98Morphological abnormality of the middle ear (HP:0008609)1.77232616
99Abnormality of the ileum (HP:0001549)1.76930530
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76580298
101Keratoconus (HP:0000563)1.76227066
102Increased corneal curvature (HP:0100692)1.76227066
103* Narrow forehead (HP:0000341)1.75819439
104Meckel diverticulum (HP:0002245)1.75771242
105* Postaxial foot polydactyly (HP:0001830)1.75547706
106Retinal dysplasia (HP:0007973)1.75193222
107Acute necrotizing encephalopathy (HP:0006965)1.74718841
108Genetic anticipation (HP:0003743)1.74144483
109Fetal akinesia sequence (HP:0001989)1.74057459
110Patellar aplasia (HP:0006443)1.73501129
111Bony spicule pigmentary retinopathy (HP:0007737)1.73314664
112Cutaneous syndactyly (HP:0012725)1.73302194
113Action tremor (HP:0002345)1.71725382
114Aplasia/Hypoplasia of the spleen (HP:0010451)1.70609406
115* Aganglionic megacolon (HP:0002251)1.70389449
116Gastrointestinal atresia (HP:0002589)1.69507898
117Chorioretinal atrophy (HP:0000533)1.69507055
118Abnormality of chromosome stability (HP:0003220)1.68917025
119* Dandy-Walker malformation (HP:0001305)1.67846527
120Fair hair (HP:0002286)1.67758748
121Aplasia/Hypoplasia of the patella (HP:0006498)1.66711333
122Aqueductal stenosis (HP:0002410)1.66124492
123Labial hypoplasia (HP:0000066)1.65582566
124* Prominent nasal bridge (HP:0000426)1.64988751
125* Multicystic kidney dysplasia (HP:0000003)1.64668089
126Inappropriate behavior (HP:0000719)1.64569911
127Visual hallucinations (HP:0002367)1.64233305
128Short foot (HP:0001773)1.64081931
129Termporal pattern (HP:0011008)1.63818837
130Insidious onset (HP:0003587)1.63818837
131Acute encephalopathy (HP:0006846)1.62957036
132Attenuation of retinal blood vessels (HP:0007843)1.62942872
133Aplasia involving bones of the extremities (HP:0009825)1.62599607
134Aplasia involving bones of the upper limbs (HP:0009823)1.62599607
135Aplasia of the phalanges of the hand (HP:0009802)1.62599607
136Ectopic kidney (HP:0000086)1.62407704
137Truncal ataxia (HP:0002078)1.62349548
138Progressive macrocephaly (HP:0004481)1.62249953
139Septo-optic dysplasia (HP:0100842)1.61804097
140* Congenital hepatic fibrosis (HP:0002612)1.60433084
141Decreased central vision (HP:0007663)1.60239072
142Specific learning disability (HP:0001328)1.59720061
143Tubulointerstitial abnormality (HP:0001969)1.58163258
144Impaired smooth pursuit (HP:0007772)1.56478335
145Abnormality of salivation (HP:0100755)1.55847234
146Generalized hypopigmentation of hair (HP:0011358)1.55243679
147Abnormality of the dental root (HP:0006486)1.55213136
148Taurodontia (HP:0000679)1.55213136
149Abnormality of permanent molar morphology (HP:0011071)1.55213136
150Volvulus (HP:0002580)1.54458874
151Abnormality of molar morphology (HP:0011070)1.51919774
152Abnormality of molar (HP:0011077)1.51919774
153* Preaxial hand polydactyly (HP:0001177)1.49700776
154Omphalocele (HP:0001539)1.49429659
155Absent frontal sinuses (HP:0002688)1.48112778
156Astigmatism (HP:0000483)1.48104246
157Abnormality of the labia minora (HP:0012880)1.47122478
158Abnormality of the nasolacrimal system (HP:0000614)1.47001067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.64012845
2MAP3K43.33104133
3MAP2K73.12276137
4EPHA43.11995439
5CASK2.83954951
6SIK32.76636945
7BMPR1B2.71676005
8PNCK2.67439272
9TNIK2.44520778
10MARK12.38633219
11LATS12.35737194
12MAP4K22.32886756
13SIK22.27871122
14TRIM281.94216659
15ZAK1.91960458
16ACVR1B1.89411718
17WNK41.83073303
18PLK21.81886994
19MAP3K91.81846445
20MINK11.81098780
21MAPK131.79916234
22PINK11.72378805
23NTRK21.69645005
24BRSK21.62536297
25GRK11.61483519
26MAP2K41.61185353
27MAP3K121.60866993
28PRPF4B1.59032662
29DYRK21.43838123
30CAMK1G1.41426532
31WEE11.40382385
32SGK21.39788062
33RIPK41.35955473
34STK161.33629528
35ERBB31.29997970
36MKNK11.26402675
37TLK11.24067508
38MAP3K61.13071171
39DAPK21.11844420
40SGK4941.11389823
41SGK2231.11389823
42TAF11.08032380
43MAPK151.07905764
44CDK31.04940923
45CDC71.04441282
46PRKD31.04415764
47BCR1.02970465
48PTK2B1.02886683
49TIE11.01978527
50PLK41.01828326
51PRKCG0.99478941
52STK380.99396886
53BMPR20.96392908
54CAMKK10.96173216
55OXSR10.96025472
56STK390.94955083
57VRK10.94579110
58CDK50.94288907
59SGK30.92347207
60NUAK10.91979321
61GRK50.91667095
62CSNK1A1L0.91306891
63PAK60.91109539
64CAMK2A0.89264955
65SRPK10.87963739
66KSR10.87901249
67CCNB10.87695517
68WNK10.85135472
69LATS20.84908941
70CSNK1G20.82319525
71PLK10.81807614
72AKT30.81268511
73YES10.81252985
74EIF2AK30.81012873
75TGFBR10.80341227
76NME10.78758352
77CAMKK20.77994454
78CAMK10.75173262
79CDK190.75028546
80TTK0.73898579
81STK38L0.71645995
82FRK0.71424266
83PDK40.71316383
84PDK30.71316383
85NEK60.70749987
86WNK30.70378265
87SGK10.69531198
88CDK80.69255192
89PRKCE0.67983987
90MST40.66618201
91DAPK10.65995852
92MARK20.65829938
93ATR0.64604290
94TSSK60.64296052
95BCKDK0.63694247
96MKNK20.62305153
97NEK20.59902592
98DYRK30.59006798
99BUB10.58869014
100DYRK1A0.58333905
101NEK10.58261598
102INSRR0.57597272
103CAMK2B0.56307841
104MAPK100.55475136
105ATM0.52895412
106PHKG20.51952978
107PHKG10.51952978
108VRK20.50336834
109BRSK10.50169792
110CSNK1G30.49721381
111MAP3K130.48415862
112CHEK20.48024514
113BRD40.47906530
114PKN10.47902380
115FER0.47134267
116CDK120.47061046
117ARAF0.46819602
118EPHB20.46656750
119STK110.46199129
120FGFR20.45288461
121NTRK10.44151660
122STK30.44040258
123MUSK0.44004556
124PAK30.42053277
125CSNK1A10.41625115
126CDK180.41535218
127PLK30.41426959
128CSNK1E0.41099280
129TYRO30.41091482
130FES0.40668449
131UHMK10.40509379
132SIK10.40418394
133CAMK1D0.40320793
134PRKACA0.40317916
135PRKG10.40223871
136ADRBK20.39098748
137CSNK1D0.37309608
138ADRBK10.36540354
139CSNK1G10.36517822
140PRKCH0.35832824
141RPS6KA50.34043731
142MAPKAPK50.33834604
143PRKCZ0.33162247
144PRKACB0.32006657
145PRKDC0.31129012

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.59789156
2Protein export_Homo sapiens_hsa030602.96311800
3Olfactory transduction_Homo sapiens_hsa047402.86615336
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78949603
5Synaptic vesicle cycle_Homo sapiens_hsa047212.54091584
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38007177
7Morphine addiction_Homo sapiens_hsa050322.30363746
8Circadian entrainment_Homo sapiens_hsa047132.29534309
9Homologous recombination_Homo sapiens_hsa034402.20855866
10Oxidative phosphorylation_Homo sapiens_hsa001902.17644179
11Glutamatergic synapse_Homo sapiens_hsa047242.17594058
12GABAergic synapse_Homo sapiens_hsa047272.14685956
13Amphetamine addiction_Homo sapiens_hsa050312.08548452
14Taste transduction_Homo sapiens_hsa047422.04684225
15Butanoate metabolism_Homo sapiens_hsa006502.04370237
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00930712
17Phototransduction_Homo sapiens_hsa047441.97168626
18RNA polymerase_Homo sapiens_hsa030201.96533943
19Long-term potentiation_Homo sapiens_hsa047201.95030363
20Selenocompound metabolism_Homo sapiens_hsa004501.94261176
21Dopaminergic synapse_Homo sapiens_hsa047281.82786711
22Non-homologous end-joining_Homo sapiens_hsa034501.79807567
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77398234
24Serotonergic synapse_Homo sapiens_hsa047261.73910930
25Salivary secretion_Homo sapiens_hsa049701.72891065
26Propanoate metabolism_Homo sapiens_hsa006401.72593551
27Parkinsons disease_Homo sapiens_hsa050121.71117027
28Huntingtons disease_Homo sapiens_hsa050161.65055492
29Linoleic acid metabolism_Homo sapiens_hsa005911.62454300
30Calcium signaling pathway_Homo sapiens_hsa040201.61645372
31Nitrogen metabolism_Homo sapiens_hsa009101.61385422
32Insulin secretion_Homo sapiens_hsa049111.61289678
33Cholinergic synapse_Homo sapiens_hsa047251.58002748
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54545673
35Axon guidance_Homo sapiens_hsa043601.54478247
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52510899
37Renin secretion_Homo sapiens_hsa049241.49893171
38Cocaine addiction_Homo sapiens_hsa050301.48912816
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.46210273
40RNA degradation_Homo sapiens_hsa030181.44124745
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42573951
42Gastric acid secretion_Homo sapiens_hsa049711.41532631
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40558515
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40399531
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37245605
46Long-term depression_Homo sapiens_hsa047301.36731385
47Collecting duct acid secretion_Homo sapiens_hsa049661.35650592
48cAMP signaling pathway_Homo sapiens_hsa040241.30272231
49Nucleotide excision repair_Homo sapiens_hsa034201.29993496
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28331480
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27827926
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26534549
53Mismatch repair_Homo sapiens_hsa034301.26197224
54Dorso-ventral axis formation_Homo sapiens_hsa043201.26028436
55Steroid biosynthesis_Homo sapiens_hsa001001.25673426
56Oxytocin signaling pathway_Homo sapiens_hsa049211.23247670
57Alzheimers disease_Homo sapiens_hsa050101.23200335
58Caffeine metabolism_Homo sapiens_hsa002321.22859621
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16905395
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15638553
61Tryptophan metabolism_Homo sapiens_hsa003801.14154014
62One carbon pool by folate_Homo sapiens_hsa006701.13096651
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11991461
64GnRH signaling pathway_Homo sapiens_hsa049121.11155757
65Chemical carcinogenesis_Homo sapiens_hsa052041.10112924
66ErbB signaling pathway_Homo sapiens_hsa040121.10023531
67Ether lipid metabolism_Homo sapiens_hsa005651.07968032
68RNA transport_Homo sapiens_hsa030131.07399413
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05746312
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05435150
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05304448
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04770035
73Gap junction_Homo sapiens_hsa045401.03912232
74Glioma_Homo sapiens_hsa052141.02533421
75Peroxisome_Homo sapiens_hsa041461.02400783
76Melanogenesis_Homo sapiens_hsa049161.02016057
77Oocyte meiosis_Homo sapiens_hsa041141.01599784
78Ovarian steroidogenesis_Homo sapiens_hsa049131.01591999
79Estrogen signaling pathway_Homo sapiens_hsa049150.99894689
80Wnt signaling pathway_Homo sapiens_hsa043100.99320198
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99306920
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96001098
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93642141
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90745491
85Proteasome_Homo sapiens_hsa030500.89332989
86Regulation of autophagy_Homo sapiens_hsa041400.89246609
87Fanconi anemia pathway_Homo sapiens_hsa034600.89035514
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86217972
89Vibrio cholerae infection_Homo sapiens_hsa051100.85475413
90beta-Alanine metabolism_Homo sapiens_hsa004100.85398601
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.84346408
92Retinol metabolism_Homo sapiens_hsa008300.83826983
93Type II diabetes mellitus_Homo sapiens_hsa049300.83747720
94Purine metabolism_Homo sapiens_hsa002300.82920610
95Ras signaling pathway_Homo sapiens_hsa040140.80943906
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80094299
97Alcoholism_Homo sapiens_hsa050340.79564986
98MAPK signaling pathway_Homo sapiens_hsa040100.79562694
99Choline metabolism in cancer_Homo sapiens_hsa052310.77368985
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76830040
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.76051120
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.75188588
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74023152
104Inositol phosphate metabolism_Homo sapiens_hsa005620.72701323
105Melanoma_Homo sapiens_hsa052180.72416537
106Pyrimidine metabolism_Homo sapiens_hsa002400.72073805
107ABC transporters_Homo sapiens_hsa020100.71790003
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70706403
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69605488
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69494090
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.68086051
112Hedgehog signaling pathway_Homo sapiens_hsa043400.67633672
113Ribosome_Homo sapiens_hsa030100.67557739
114Rheumatoid arthritis_Homo sapiens_hsa053230.66848170
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66486856
116Rap1 signaling pathway_Homo sapiens_hsa040150.65999078
117Thyroid hormone synthesis_Homo sapiens_hsa049180.65613223
118Metabolic pathways_Homo sapiens_hsa011000.65082529
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.64778562
120Dilated cardiomyopathy_Homo sapiens_hsa054140.64453237
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61820839
122Cell cycle_Homo sapiens_hsa041100.60682570
123Base excision repair_Homo sapiens_hsa034100.60493650
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59403627
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58878907
126Basal cell carcinoma_Homo sapiens_hsa052170.58225985
127Circadian rhythm_Homo sapiens_hsa047100.57641483
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56631387
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54804749
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54220667
131Colorectal cancer_Homo sapiens_hsa052100.54022075
132DNA replication_Homo sapiens_hsa030300.53190443
133Pancreatic secretion_Homo sapiens_hsa049720.52777345
134Fatty acid metabolism_Homo sapiens_hsa012120.52387106
135Mineral absorption_Homo sapiens_hsa049780.52274010
136mRNA surveillance pathway_Homo sapiens_hsa030150.52033118
137Histidine metabolism_Homo sapiens_hsa003400.51099891
138Spliceosome_Homo sapiens_hsa030400.50888950
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50692627
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50529053
141Hippo signaling pathway_Homo sapiens_hsa043900.49948879
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.49233463
143Renal cell carcinoma_Homo sapiens_hsa052110.49015939
144Endometrial cancer_Homo sapiens_hsa052130.48364163
145Type I diabetes mellitus_Homo sapiens_hsa049400.46589307
146Prostate cancer_Homo sapiens_hsa052150.46173550
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.46118274
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46001096
149Glucagon signaling pathway_Homo sapiens_hsa049220.45956899
150Basal transcription factors_Homo sapiens_hsa030220.45192877
151Glycerolipid metabolism_Homo sapiens_hsa005610.44457935
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43897333
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43371774
154Pyruvate metabolism_Homo sapiens_hsa006200.43244986
155Cardiac muscle contraction_Homo sapiens_hsa042600.42348189
156Endocytosis_Homo sapiens_hsa041440.42084643
157Phagosome_Homo sapiens_hsa041450.42012542
158Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41620784
159Lysine degradation_Homo sapiens_hsa003100.41311294
160Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41099384
161Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39713507
162Chemokine signaling pathway_Homo sapiens_hsa040620.37690765
163MicroRNAs in cancer_Homo sapiens_hsa052060.37354602
164Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37299333
165TGF-beta signaling pathway_Homo sapiens_hsa043500.36747988
166Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35485418
167Non-small cell lung cancer_Homo sapiens_hsa052230.35265603

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