RPH3AL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocrine pancreas development (GO:0031018)7.51185625
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.34938043
3COPII vesicle coating (GO:0048208)7.21574902
4protein retention in ER lumen (GO:0006621)6.51563766
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.35989022
6peptide hormone processing (GO:0016486)6.34684231
7type B pancreatic cell development (GO:0003323)6.00252075
8glandular epithelial cell differentiation (GO:0002067)5.95429368
9protein maturation by protein folding (GO:0022417)5.86817409
10regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.59928160
11glandular epithelial cell development (GO:0002068)5.54344229
12exocrine pancreas development (GO:0031017)5.46753399
13positive regulation of insulin secretion (GO:0032024)5.37183591
14regulation of type B pancreatic cell apoptotic process (GO:2000674)5.34328869
15signal peptide processing (GO:0006465)5.31660284
16activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.27570950
17positive regulation of nuclease activity (GO:0032075)5.03580025
18vesicle coating (GO:0006901)5.01007706
19sequestering of metal ion (GO:0051238)4.91369898
20columnar/cuboidal epithelial cell development (GO:0002066)4.62544879
21insulin secretion (GO:0030073)4.59937162
22regulation of nuclease activity (GO:0032069)4.57063417
23ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.56293255
24regulation of insulin secretion (GO:0050796)4.47641753
25endoplasmic reticulum unfolded protein response (GO:0030968)4.39242758
26L-alpha-amino acid transmembrane transport (GO:1902475)4.35941003
27cellular response to topologically incorrect protein (GO:0035967)4.32291546
28positive regulation of peptide hormone secretion (GO:0090277)4.31836172
29cellular response to unfolded protein (GO:0034620)4.31341891
30water-soluble vitamin biosynthetic process (GO:0042364)4.17085417
31ER overload response (GO:0006983)4.13855139
32positive regulation of peptide secretion (GO:0002793)4.13579913
33ER-nucleus signaling pathway (GO:0006984)4.11897312
34regulation of peptide hormone secretion (GO:0090276)4.06750141
35negative regulation of glycoprotein biosynthetic process (GO:0010561)3.98302389
36regulation of peptide secretion (GO:0002791)3.97902403
37epithelial cell fate commitment (GO:0072148)3.87483640
38cellular ketone body metabolic process (GO:0046950)3.85703412
39negative regulation of insulin secretion (GO:0046676)3.79930192
40ER to Golgi vesicle-mediated transport (GO:0006888)3.77652609
41toxin metabolic process (GO:0009404)3.72760702
42protein N-linked glycosylation via asparagine (GO:0018279)3.68717357
43peptidyl-asparagine modification (GO:0018196)3.67726511
44intestinal epithelial cell development (GO:0060576)3.65371857
45cellular response to vitamin D (GO:0071305)3.61040624
46nitric oxide mediated signal transduction (GO:0007263)3.60841236
47response to endoplasmic reticulum stress (GO:0034976)3.58104992
48regulation of glucocorticoid secretion (GO:2000849)3.57025971
49cellular zinc ion homeostasis (GO:0006882)3.53358488
50regulation of hormone secretion (GO:0046883)3.52424459
51glycerophospholipid catabolic process (GO:0046475)3.50679059
52regulation of Golgi to plasma membrane protein transport (GO:0042996)3.50317007
53peptide hormone secretion (GO:0030072)3.50252060
54intra-Golgi vesicle-mediated transport (GO:0006891)3.45326800
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.44663626
56L-phenylalanine catabolic process (GO:0006559)3.44663626
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.42806454
58L-phenylalanine metabolic process (GO:0006558)3.42806454
59peptide secretion (GO:0002790)3.40431528
60positive regulation of hormone secretion (GO:0046887)3.39605174
61response to unfolded protein (GO:0006986)3.38283186
62response to topologically incorrect protein (GO:0035966)3.37694040
63protein N-linked glycosylation (GO:0006487)3.35576955
64Golgi organization (GO:0007030)3.34948649
65ketone body metabolic process (GO:1902224)3.34367378
66intestinal absorption (GO:0050892)3.31545027
67response to misfolded protein (GO:0051788)3.27973143
68negative regulation of peptide hormone secretion (GO:0090278)3.26570280
69signal transduction involved in regulation of gene expression (GO:0023019)3.26432814
70regulation of peptide transport (GO:0090087)3.25092965
71macroautophagy (GO:0016236)3.24601180
72aromatic amino acid family catabolic process (GO:0009074)3.22997713
73amine catabolic process (GO:0009310)3.22736390
74cellular biogenic amine catabolic process (GO:0042402)3.22736390
75detection of calcium ion (GO:0005513)3.20508788
76regulation of glucokinase activity (GO:0033131)3.20065076
77regulation of hexokinase activity (GO:1903299)3.20065076
78response to hexose (GO:0009746)3.17055507
79negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.15998548
80regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.15356432
81regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.15356432
82astrocyte differentiation (GO:0048708)3.14466201
83negative regulation of peptide secretion (GO:0002792)3.14312720
84organic cation transport (GO:0015695)3.14250200
85regulation of corticosteroid hormone secretion (GO:2000846)3.09442899
86inositol phosphate catabolic process (GO:0071545)3.08845157
87response to glucose (GO:0009749)3.07251099
88reflex (GO:0060004)3.06545898
89intestinal cholesterol absorption (GO:0030299)3.05989325
90respiratory chain complex IV assembly (GO:0008535)3.05976615
91GDP-mannose metabolic process (GO:0019673)3.04061186
92tryptophan catabolic process (GO:0006569)3.03739124
93indole-containing compound catabolic process (GO:0042436)3.03739124
94indolalkylamine catabolic process (GO:0046218)3.03739124
95protein localization to Golgi apparatus (GO:0034067)3.01709636
96negative regulation of catecholamine secretion (GO:0033604)3.00432678
97response to monosaccharide (GO:0034284)2.99467670
98growth hormone secretion (GO:0030252)2.98278122
99positive regulation of glycolytic process (GO:0045821)2.98159379
100misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.96515005
101peptide transport (GO:0015833)2.95303251
102indolalkylamine metabolic process (GO:0006586)2.95249317
103negative regulation of norepinephrine secretion (GO:0010700)2.92724380
104regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.92500236
105protein complex biogenesis (GO:0070271)2.91897723
106phosphorylated carbohydrate dephosphorylation (GO:0046838)2.90078947
107inositol phosphate dephosphorylation (GO:0046855)2.90078947
108negative regulation of execution phase of apoptosis (GO:1900118)2.87494903
109behavioral response to nicotine (GO:0035095)2.87295443
110digestion (GO:0007586)2.87221933
111negative regulation of glycoprotein metabolic process (GO:1903019)2.87083703
112nephron tubule morphogenesis (GO:0072078)2.86474634
113nephron epithelium morphogenesis (GO:0072088)2.86474634
114cytochrome complex assembly (GO:0017004)2.86311582
115negative regulation of bone resorption (GO:0045779)2.86182960
116positive regulation of prostaglandin secretion (GO:0032308)2.85833966
117xenobiotic catabolic process (GO:0042178)2.85832482
118maintenance of protein localization in organelle (GO:0072595)2.85683755
119* glucose homeostasis (GO:0042593)2.85408006
120* carbohydrate homeostasis (GO:0033500)2.85408006
121folic acid-containing compound biosynthetic process (GO:0009396)2.85183209
122membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.84256841
123positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.83375366
124Golgi vesicle transport (GO:0048193)2.82671149
125fatty acid homeostasis (GO:0055089)2.82373639
126positive regulation of vesicle fusion (GO:0031340)2.81381016
127L-fucose catabolic process (GO:0042355)2.81113915
128fucose catabolic process (GO:0019317)2.81113915
129L-fucose metabolic process (GO:0042354)2.81113915
130pteridine-containing compound biosynthetic process (GO:0042559)2.80576306
131hormone secretion (GO:0046879)2.80108193
132regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.79794571
133pancreas development (GO:0031016)2.79744200
134ubiquinone biosynthetic process (GO:0006744)2.75333197
135regulation of neurotransmitter uptake (GO:0051580)2.68269330
136platelet dense granule organization (GO:0060155)2.68145869
137polyol catabolic process (GO:0046174)2.65956352
138polyketide metabolic process (GO:0030638)2.63971347
139doxorubicin metabolic process (GO:0044598)2.63971347
140daunorubicin metabolic process (GO:0044597)2.63971347
141quinone biosynthetic process (GO:1901663)2.61885391
142quinone metabolic process (GO:1901661)2.60803536
143regulation of acrosome reaction (GO:0060046)2.60048650
144exogenous drug catabolic process (GO:0042738)2.59256740
145positive regulation of fatty acid transport (GO:2000193)2.57960648
146mitochondrial respiratory chain complex assembly (GO:0033108)2.57647695
1473-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.54739763
148purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.54739763
149primary amino compound metabolic process (GO:1901160)2.54712852
150negative regulation of multicellular organism growth (GO:0040015)2.53254770
151tryptophan metabolic process (GO:0006568)2.50458943
152adaptation of signaling pathway (GO:0023058)2.48304426
153dopamine transport (GO:0015872)2.46408805
154mannosylation (GO:0097502)2.45624519
155L-ascorbic acid metabolic process (GO:0019852)2.44840894
156indole-containing compound metabolic process (GO:0042430)2.44407519
157aminoglycoside antibiotic metabolic process (GO:0030647)2.44384886
158auditory receptor cell stereocilium organization (GO:0060088)2.43502331
159renal tubule morphogenesis (GO:0061333)2.42947493
160positive regulation of icosanoid secretion (GO:0032305)2.42650521
161neuronal action potential (GO:0019228)2.42311240
162alanine transport (GO:0032328)2.40906691
163nitric oxide biosynthetic process (GO:0006809)2.39612997
164preassembly of GPI anchor in ER membrane (GO:0016254)2.39340725
165drug catabolic process (GO:0042737)2.37790904
166regulation of triglyceride biosynthetic process (GO:0010866)2.37060736
167detection of light stimulus involved in visual perception (GO:0050908)2.36983005
168detection of light stimulus involved in sensory perception (GO:0050962)2.36983005
169nucleotide transmembrane transport (GO:1901679)2.36629394
170kynurenine metabolic process (GO:0070189)2.36361839
171ubiquinone metabolic process (GO:0006743)2.36170055
172regulation of prostaglandin secretion (GO:0032306)2.34798900
173multicellular organism reproduction (GO:0032504)2.34589214
174aromatic amino acid family metabolic process (GO:0009072)2.33604943
175cellular response to zinc ion (GO:0071294)2.32376307
176arginine metabolic process (GO:0006525)2.31847615
177branched-chain amino acid catabolic process (GO:0009083)2.31334085
178zinc ion transmembrane transport (GO:0071577)2.29406324
179oxidative demethylation (GO:0070989)2.29313912
180positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.29306161
181cilium morphogenesis (GO:0060271)2.29267107
182benzene-containing compound metabolic process (GO:0042537)2.28726217
183phenylpropanoid metabolic process (GO:0009698)2.27864638
184thyroid hormone metabolic process (GO:0042403)2.27318851
185COPI coating of Golgi vesicle (GO:0048205)11.1375265
186Golgi transport vesicle coating (GO:0048200)11.1375265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.66110619
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.65866415
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse4.00455341
4ZNF274_21170338_ChIP-Seq_K562_Hela3.57476260
5GATA1_22025678_ChIP-Seq_K562_Human2.86766398
6PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.63797292
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52570979
8GBX2_23144817_ChIP-Seq_PC3_Human2.37969034
9SOX2_27498859_Chip-Seq_STOMACH_Mouse2.34488982
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31622601
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26066754
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15930114
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.10805885
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00484078
15CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.97736983
16* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.89124964
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.88649095
18EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88167468
19BCAT_22108803_ChIP-Seq_LS180_Human1.80201292
20* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.79518994
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74409071
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72966844
23ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70719193
24IGF1R_20145208_ChIP-Seq_DFB_Human1.69597470
25* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68519793
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68089185
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66983576
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.64998979
29* FOXA1_25552417_ChIP-Seq_VCAP_Human1.63919884
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.63833599
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.63741831
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.62769049
33REST_19997604_ChIP-ChIP_NEURONS_Mouse1.62409369
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59051643
35OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.58815234
36ERG_20517297_ChIP-Seq_VCAP_Human1.58698740
37FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.57995741
38ER_23166858_ChIP-Seq_MCF-7_Human1.57445734
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54972828
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54223894
41* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.51447018
42* FOXA1_25329375_ChIP-Seq_VCAP_Human1.51447018
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.50696995
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50528968
45CLOCK_20551151_ChIP-Seq_293T_Human1.49353987
46AR_20517297_ChIP-Seq_VCAP_Human1.47086105
47* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46532033
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.45031477
49AR_25329375_ChIP-Seq_VCAP_Human1.43973286
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.42340526
51P300_19829295_ChIP-Seq_ESCs_Human1.41750900
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41729197
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40633566
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40039484
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39201031
56* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.38898443
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37866495
58SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.37125345
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36443872
60GATA6_25053715_ChIP-Seq_YYC3_Human1.35076914
61GATA4_25053715_ChIP-Seq_YYC3_Human1.34270571
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.34035537
63* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.33755692
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33620309
65PKCTHETA_26484144_Chip-Seq_BREAST_Human1.33026553
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31694790
67SMAD4_21799915_ChIP-Seq_A2780_Human1.30649163
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29524007
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28964298
70CBP_20019798_ChIP-Seq_JUKART_Human1.28964298
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28162410
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.28063026
73TFEB_21752829_ChIP-Seq_HELA_Human1.27511085
74VDR_22108803_ChIP-Seq_LS180_Human1.26676916
75HTT_18923047_ChIP-ChIP_STHdh_Human1.25970729
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24893393
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24037945
78CDX2_22108803_ChIP-Seq_LS180_Human1.23398036
79NCOR_22424771_ChIP-Seq_293T_Human1.22792340
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20396132
81NANOG_19829295_ChIP-Seq_ESCs_Human1.19608516
82SOX2_19829295_ChIP-Seq_ESCs_Human1.19608516
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19291570
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18971531
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18875854
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18667871
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.18388441
88* TCF4_23295773_ChIP-Seq_U87_Human1.18382970
89ERA_21632823_ChIP-Seq_H3396_Human1.18073605
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15443751
91MYC_19829295_ChIP-Seq_ESCs_Human1.14920815
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14912232
93TCF4_22108803_ChIP-Seq_LS180_Human1.14617627
94HOXB7_26014856_ChIP-Seq_BT474_Human1.13167734
95CHD1_26751641_Chip-Seq_LNCaP_Human1.12940585
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11222649
97SOX2_20726797_ChIP-Seq_SW620_Human1.11069012
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10012203
99GATA3_27048872_Chip-Seq_THYMUS_Human1.09996479
100GABP_19822575_ChIP-Seq_HepG2_Human1.09681554
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09631497
102GATA1_19941826_ChIP-Seq_K562_Human1.09067720
103* GATA3_24758297_ChIP-Seq_MCF-7_Human1.08871405
104RUNX2_22187159_ChIP-Seq_PCA_Human1.08723513
105GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.07306367
106PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07149488
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07007232
108TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06618466
109CBP_21632823_ChIP-Seq_H3396_Human1.06414846
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05394828
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04697014
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04682606
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03651776
114TBX20_22080862_ChIP-Seq_HEART_Mouse1.03613779
115TBX20_22328084_ChIP-Seq_HEART_Mouse1.03613779
116FOXH1_21741376_ChIP-Seq_EPCs_Human1.03596566
117TAF2_19829295_ChIP-Seq_ESCs_Human1.02807916
118NANOG_20526341_ChIP-Seq_ESCs_Human1.02802281
119REST_21632747_ChIP-Seq_MESCs_Mouse1.01832537
120EZH2_22144423_ChIP-Seq_EOC_Human1.01777976
121REST_18959480_ChIP-ChIP_MESCs_Mouse1.01028846
122FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00746530
123VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00466946
124ATF3_27146783_Chip-Seq_COLON_Human0.99167876
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98620000
126SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97348517
127* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97197920
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.96454604
129MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95930031
130ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95446823
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95141492
132AHR_22903824_ChIP-Seq_MCF-7_Human0.94941251
133RUNX1_27514584_Chip-Seq_MCF-7_Human0.94903780
134* FOXA2_19822575_ChIP-Seq_HepG2_Human0.93189803
135GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93055420
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92705543
137STAT3_18555785_Chip-Seq_ESCs_Mouse0.92234794
138* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92169173
139CREB1_26743006_Chip-Seq_LNCaP_Human0.91914903
140NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91745695
141* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91163814
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91076093
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90583792
144KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.89955620
145RAC3_21632823_ChIP-Seq_H3396_Human0.89620111
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.89326463
147CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89130667
148RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88898924
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88542557
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88516280
151FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88383481
152KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88374645
153TP53_22573176_ChIP-Seq_HFKS_Human0.87640947
154LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85902402
155KDM5A_27292631_Chip-Seq_BREAST_Human0.85780731
156* STAT3_23295773_ChIP-Seq_U87_Human0.85563480
157TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85261648
158* GF1B_26923725_Chip-Seq_HPCs_Mouse0.84832381
159ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83513285
160JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.83382151
161CIITA_25753668_ChIP-Seq_RAJI_Human0.82597278
162FOXH1_21741376_ChIP-Seq_ESCs_Human0.81965877
163CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81553467
164SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80945727
165NANOG_21062744_ChIP-ChIP_HESCs_Human0.79637800
166TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79435637
167ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79386920
168FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79063806
169CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78901933
170TET1_21490601_ChIP-Seq_MESCs_Mouse0.78500614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.27956317
2MP0000013_abnormal_adipose_tissue4.13491322
3MP0003283_abnormal_digestive_organ4.10481551
4MP0004043_abnormal_pH_regulation4.01000686
5MP0001944_abnormal_pancreas_morphology3.97802588
6* MP0002693_abnormal_pancreas_physiology3.96250814
7MP0002909_abnormal_adrenal_gland3.61812073
8MP0010386_abnormal_urinary_bladder3.54966888
9MP0000678_abnormal_parathyroid_gland3.49091339
10MP0008875_abnormal_xenobiotic_pharmacok3.27790487
11MP0003195_calcinosis3.23321217
12MP0003183_abnormal_peptide_metabolism3.18296101
13MP0009780_abnormal_chondrocyte_physiolo3.03225669
14MP0005379_endocrine/exocrine_gland_phen3.03015243
15MP0002837_dystrophic_cardiac_calcinosis2.89236423
16MP0004264_abnormal_extraembryonic_tissu2.79359610
17* MP0005220_abnormal_exocrine_pancreas2.65978865
18MP0000003_abnormal_adipose_tissue2.43866152
19MP0005451_abnormal_body_composition2.34508780
20MP0006072_abnormal_retinal_apoptosis2.26761518
21* MP0002078_abnormal_glucose_homeostasis2.24021313
22MP0002638_abnormal_pupillary_reflex2.12695067
23MP0009046_muscle_twitch2.00541604
24MP0010329_abnormal_lipoprotein_level1.98897042
25MP0008872_abnormal_physiological_respon1.97930301
26MP0005646_abnormal_pituitary_gland1.95647494
27MP0005645_abnormal_hypothalamus_physiol1.87603164
28MP0003122_maternal_imprinting1.86291920
29MP0000462_abnormal_digestive_system1.84438826
30MP0005332_abnormal_amino_acid1.82852556
31MP0005365_abnormal_bile_salt1.82612565
32MP0001765_abnormal_ion_homeostasis1.74448905
33MP0008961_abnormal_basal_metabolism1.71218305
34MP0002928_abnormal_bile_duct1.68472063
35MP0000613_abnormal_salivary_gland1.66703886
36MP0003300_gastrointestinal_ulcer1.65400022
37MP0002138_abnormal_hepatobiliary_system1.60949498
38MP0003868_abnormal_feces_composition1.56189665
39MP0005551_abnormal_eye_electrophysiolog1.54843510
40MP0003123_paternal_imprinting1.53034300
41MP0009643_abnormal_urine_homeostasis1.52577859
42MP0002234_abnormal_pharynx_morphology1.51335442
43MP0001666_abnormal_nutrient_absorption1.49609102
44MP0001905_abnormal_dopamine_level1.49533389
45MP0003953_abnormal_hormone_level1.45428877
46MP0003011_delayed_dark_adaptation1.44085862
47MP0005084_abnormal_gallbladder_morpholo1.40711157
48MP0002160_abnormal_reproductive_system1.39673272
49MP0003787_abnormal_imprinting1.37824522
50MP0005257_abnormal_intraocular_pressure1.37436805
51MP0004019_abnormal_vitamin_homeostasis1.33224596
52MP0003959_abnormal_lean_body1.32297093
53MP0001756_abnormal_urination1.31699644
54MP0005360_urolithiasis1.26504982
55MP0006036_abnormal_mitochondrial_physio1.24955265
56MP0002139_abnormal_hepatobiliary_system1.23497406
57MP0005408_hypopigmentation1.22811221
58MP0000427_abnormal_hair_cycle1.22423704
59MP0002896_abnormal_bone_mineralization1.20088134
60MP0003252_abnormal_bile_duct1.19312536
61MP0005636_abnormal_mineral_homeostasis1.18924591
62MP0002163_abnormal_gland_morphology1.17581992
63MP0005310_abnormal_salivary_gland1.15841926
64MP0000631_abnormal_neuroendocrine_gland1.14609258
65MP0004133_heterotaxia1.13190296
66MP0005375_adipose_tissue_phenotype1.11743123
67MP0000639_abnormal_adrenal_gland1.09834893
68MP0010234_abnormal_vibrissa_follicle1.08657156
69MP0005187_abnormal_penis_morphology1.08656882
70MP0005670_abnormal_white_adipose1.08474759
71MP0003693_abnormal_embryo_hatching1.08266853
72MP0000538_abnormal_urinary_bladder1.07803485
73MP0002102_abnormal_ear_morphology1.02905388
74MP0001501_abnormal_sleep_pattern1.02254539
75MP0002653_abnormal_ependyma_morphology1.01405361
76MP0009840_abnormal_foam_cell1.00876332
77MP0003119_abnormal_digestive_system1.00535482
78MP0001270_distended_abdomen0.99332002
79MP0003121_genomic_imprinting0.96366910
80MP0005389_reproductive_system_phenotype0.95535283
81MP0001986_abnormal_taste_sensitivity0.94354103
82MP0001502_abnormal_circadian_rhythm0.94344282
83MP0008775_abnormal_heart_ventricle0.93962056
84MP0004215_abnormal_myocardial_fiber0.93043437
85MP0005083_abnormal_biliary_tract0.92380209
86MP0005410_abnormal_fertilization0.92269820
87MP0002557_abnormal_social/conspecific_i0.90475623
88MP0002272_abnormal_nervous_system0.89622162
89MP0006292_abnormal_olfactory_placode0.89340210
90MP0005266_abnormal_metabolism0.88698230
91MP0005253_abnormal_eye_physiology0.88301657
92MP0009745_abnormal_behavioral_response0.86703420
93MP0003646_muscle_fatigue0.86695628
94MP0003172_abnormal_lysosome_physiology0.86538705
95MP0004924_abnormal_behavior0.85895947
96MP0005386_behavior/neurological_phenoty0.85895947
97MP0004147_increased_porphyrin_level0.85478483
98MP0005058_abnormal_lysosome_morphology0.85204560
99MP0003866_abnormal_defecation0.82745931
100MP0005448_abnormal_energy_balance0.82300678
101MP0002572_abnormal_emotion/affect_behav0.81720587
102MP0002822_catalepsy0.80562484
103MP0005535_abnormal_body_temperature0.80185885
104MP0004142_abnormal_muscle_tone0.79907099
105MP0002733_abnormal_thermal_nociception0.79433490
106MP0000230_abnormal_systemic_arterial0.78911970
107MP0009672_abnormal_birth_weight0.78432331
108MP0004782_abnormal_surfactant_physiolog0.78312518
109MP0006054_spinal_hemorrhage0.76744602
110MP0001664_abnormal_digestion0.76123258
111MP0010678_abnormal_skin_adnexa0.75988007
112MP0004145_abnormal_muscle_electrophysio0.75275461
113MP0000383_abnormal_hair_follicle0.74347122
114MP0002069_abnormal_eating/drinking_beha0.74219340
115MP0003890_abnormal_embryonic-extraembry0.71766308
116MP0005319_abnormal_enzyme/_coenzyme0.71660797
117MP0001764_abnormal_homeostasis0.71526229
118MP0003879_abnormal_hair_cell0.71451785
119MP0004085_abnormal_heartbeat0.71419846
120MP0002332_abnormal_exercise_endurance0.71177392
121MP0008877_abnormal_DNA_methylation0.69794522
122MP0001968_abnormal_touch/_nociception0.69148935
123MP0004270_analgesia0.66824399
124MP0005085_abnormal_gallbladder_physiolo0.65731918
125MP0002876_abnormal_thyroid_physiology0.65481427
126MP0003045_fibrosis0.62810900
127MP0002118_abnormal_lipid_homeostasis0.62449414
128MP0004185_abnormal_adipocyte_glucose0.61030108
129MP0002168_other_aberrant_phenotype0.60300906
130MP0004233_abnormal_muscle_weight0.59737498
131MP0002970_abnormal_white_adipose0.58484376
132MP0002177_abnormal_outer_ear0.56938848
133MP0005452_abnormal_adipose_tissue0.55233703
134MP0005076_abnormal_cell_differentiation0.54672804
135MP0002269_muscular_atrophy0.54585656
136MP0005334_abnormal_fat_pad0.54456227
137MP0005395_other_phenotype0.53964318
138MP0001849_ear_inflammation0.53929278
139MP0004036_abnormal_muscle_relaxation0.53505225
140MP0009703_decreased_birth_body0.53446430
141MP0001661_extended_life_span0.51496737
142* MP0009642_abnormal_blood_homeostasis0.50828437
143MP0003699_abnormal_female_reproductive0.49465954
144MP0000470_abnormal_stomach_morphology0.48621279

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.94618680
2Hypoglycemic seizures (HP:0002173)7.29578217
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.22570901
4Hypoglycemic coma (HP:0001325)6.73827511
5Symptomatic seizures (HP:0011145)6.65921324
6Hyperglycemia (HP:0003074)5.93223737
7Insulin-resistant diabetes mellitus (HP:0000831)5.41152161
8Abnormality of endocrine pancreas physiology (HP:0012093)5.24576421
9Abnormality of the pancreatic islet cells (HP:0006476)5.24576421
10Ketoacidosis (HP:0001993)5.10452695
11Abnormality of calcium-phosphate metabolism (HP:0100530)5.04548613
12Late onset (HP:0003584)4.82942467
13Pancreatic islet-cell hyperplasia (HP:0004510)4.58973521
14Large for gestational age (HP:0001520)4.19879979
15Abnormal pancreas size (HP:0012094)4.05626815
16Decreased circulating renin level (HP:0003351)4.03202759
17Pancreatic cysts (HP:0001737)3.64576532
18Pancreatic fibrosis (HP:0100732)3.60291858
19Insulin resistance (HP:0000855)3.54847351
20True hermaphroditism (HP:0010459)3.54212872
21Abnormality of midbrain morphology (HP:0002418)3.52319156
22Molar tooth sign on MRI (HP:0002419)3.52319156
23Mucopolysacchariduria (HP:0008155)3.30913117
24Urinary glycosaminoglycan excretion (HP:0003541)3.30913117
25Hyperparathyroidism (HP:0000843)3.30151387
26Abnormality of polysaccharide metabolism (HP:0011012)3.22493867
27Abnormality of glycosaminoglycan metabolism (HP:0004371)3.22493867
28Abnormality of mucopolysaccharide metabolism (HP:0011020)3.22493867
29Abnormality of aromatic amino acid family metabolism (HP:0004338)3.18108866
30Hypokalemia (HP:0002900)3.15910253
31Gout (HP:0001997)3.13856352
32Dysostosis multiplex (HP:0000943)3.13625587
33Cystic liver disease (HP:0006706)3.09944639
34Agitation (HP:0000713)3.09879848
35Generalized aminoaciduria (HP:0002909)3.08181372
36Ketosis (HP:0001946)3.05535824
37Type II lissencephaly (HP:0007260)3.02838901
38Hyperventilation (HP:0002883)2.99363218
39Nephronophthisis (HP:0000090)2.96365398
40Chronic bronchitis (HP:0004469)2.91466648
41Retinal atrophy (HP:0001105)2.89985763
42Hyperactive renin-angiotensin system (HP:0000841)2.89549069
43Abnormality of the intrinsic pathway (HP:0010989)2.77055546
44Abnormality of renin-angiotensin system (HP:0000847)2.72131895
45Hyperkalemia (HP:0002153)2.70991930
46Abnormality of the renal cortex (HP:0011035)2.67150847
47Medial flaring of the eyebrow (HP:0010747)2.66752177
48Hepatic necrosis (HP:0002605)2.63295601
49Severe muscular hypotonia (HP:0006829)2.61833252
50Abnormality of the renal medulla (HP:0100957)2.61102988
51Hypoplasia of the fovea (HP:0007750)2.58739295
52Aplasia/Hypoplasia of the fovea (HP:0008060)2.58739295
53Conjugated hyperbilirubinemia (HP:0002908)2.58149511
54Exocrine pancreatic insufficiency (HP:0001738)2.58045056
55Abnormality of the fovea (HP:0000493)2.57564272
56Prominent metopic ridge (HP:0005487)2.56944931
57Abnormality of potassium homeostasis (HP:0011042)2.56038142
58Hyperphosphatemia (HP:0002905)2.55669394
59Unilateral renal agenesis (HP:0000122)2.55229094
60Abnormal drinking behavior (HP:0030082)2.54029739
61Polydipsia (HP:0001959)2.54029739
62Limb hypertonia (HP:0002509)2.51668796
63Enlarged penis (HP:0000040)2.49964698
64Congenital stationary night blindness (HP:0007642)2.49219702
65Furrowed tongue (HP:0000221)2.48119195
66Osteomalacia (HP:0002749)2.47716312
67Hypercortisolism (HP:0001578)2.45252799
68Menstrual irregularities (HP:0000858)2.44444185
69Male pseudohermaphroditism (HP:0000037)2.38831410
70Abnormality of small intestinal villus morphology (HP:0011472)2.37219775
71Villous atrophy (HP:0011473)2.37219775
72Hypomagnesemia (HP:0002917)2.34309016
73Abnormality of chloride homeostasis (HP:0011422)2.31590122
74Tubular atrophy (HP:0000092)2.30635183
75Dysautonomia (HP:0002459)2.30517866
76Thoracolumbar scoliosis (HP:0002944)2.29798962
77Progressive neurologic deterioration (HP:0002344)2.27630931
78Hypotension (HP:0002615)2.26739430
79Abnormal rod and cone electroretinograms (HP:0008323)2.23411476
80Acute necrotizing encephalopathy (HP:0006965)2.21298831
81Progressive macrocephaly (HP:0004481)2.20372933
82Mitochondrial inheritance (HP:0001427)2.19288024
83Polyuria (HP:0000103)2.18907576
84Acute encephalopathy (HP:0006846)2.18005454
85EEG with generalized epileptiform discharges (HP:0011198)2.17339625
86Hypsarrhythmia (HP:0002521)2.17186919
87Abnormality of the metopic suture (HP:0005556)2.16445966
88Absent speech (HP:0001344)2.15410230
89Papillary thyroid carcinoma (HP:0002895)2.14649871
90Growth hormone excess (HP:0000845)2.13967063
91Pheochromocytoma (HP:0002666)2.11164018
92Sclerocornea (HP:0000647)2.10667865
93Pendular nystagmus (HP:0012043)2.09949191
94Vascular calcification (HP:0004934)2.09164708
95Adrenal overactivity (HP:0002717)2.08936769
96Attenuation of retinal blood vessels (HP:0007843)2.07998079
97Abdominal distention (HP:0003270)2.07969493
98Hepatocellular necrosis (HP:0001404)2.06159024
99Abnormal biliary tract morphology (HP:0012440)2.05147904
100Delayed gross motor development (HP:0002194)2.05011869
101Generalized hyperpigmentation (HP:0007440)2.04043416
102Epileptiform EEG discharges (HP:0011182)2.03781430
103Renal cortical cysts (HP:0000803)2.02090077
104Irregular vertebral endplates (HP:0003301)2.02002234
105Papilledema (HP:0001085)2.01431653
106Aplasia/Hypoplasia of the tongue (HP:0010295)2.01245550
107Abnormality of magnesium homeostasis (HP:0004921)2.00742353
108Hypophosphatemia (HP:0002148)2.00654012
109Abnormal urine output (HP:0012590)2.00295875
110Testicular neoplasm (HP:0010788)2.00192644
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00117669
112Abnormal protein N-linked glycosylation (HP:0012347)2.00117669
113Abnormal protein glycosylation (HP:0012346)2.00117669
114Abnormal glycosylation (HP:0012345)2.00117669
115Abnormality of renal excretion (HP:0011036)1.98994205
116Hyperglycinuria (HP:0003108)1.97646351
117Gait imbalance (HP:0002141)1.95434045
118Methylmalonic aciduria (HP:0012120)1.94402561
119Abnormality of purine metabolism (HP:0004352)1.94301138
120Hypoplastic labia majora (HP:0000059)1.93588299
121Hypothermia (HP:0002045)1.92587572
122Mesangial abnormality (HP:0001966)1.92288775
123Xanthomatosis (HP:0000991)1.92215890
124Congenital hepatic fibrosis (HP:0002612)1.92149456
125Congenital sensorineural hearing impairment (HP:0008527)1.92052159
126Cortical visual impairment (HP:0100704)1.90501125
127Inability to walk (HP:0002540)1.90132774
128Gaze-evoked nystagmus (HP:0000640)1.89898241
129Aplasia/hypoplasia of the uterus (HP:0008684)1.89180310
130Azoospermia (HP:0000027)1.88857165
131Increased CSF lactate (HP:0002490)1.88798386
132Congenital primary aphakia (HP:0007707)1.88387956
133Methylmalonic acidemia (HP:0002912)1.88139564
134Abnormal mitochondria in muscle tissue (HP:0008316)1.87533437
135Congenital glaucoma (HP:0001087)1.87375884
136Male infertility (HP:0003251)1.87196862
137Delayed CNS myelination (HP:0002188)1.84505261
138Macroorchidism (HP:0000053)1.84317673
139Hyperphosphaturia (HP:0003109)1.84066613
140Abnormality of vitamin B metabolism (HP:0004340)1.82777545
141Hypokalemic alkalosis (HP:0001949)1.81296575
142Congenital, generalized hypertrichosis (HP:0004540)1.80610524
143Neuroendocrine neoplasm (HP:0100634)1.79629895
144Flat capital femoral epiphysis (HP:0003370)1.78647835
145Abnormality of the labia majora (HP:0012881)1.78559007
146Hemiparesis (HP:0001269)1.78438950
147Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77388162
148Dicarboxylic aciduria (HP:0003215)1.77388162
149Abnormal biliary tract physiology (HP:0012439)1.76289313
150Bile duct proliferation (HP:0001408)1.76289313
151Intestinal atresia (HP:0011100)1.75827552
152Restlessness (HP:0000711)1.74916743
153Occipital encephalocele (HP:0002085)1.72643938
154Hyperaldosteronism (HP:0000859)1.72620738
155Abnormality of serine family amino acid metabolism (HP:0010894)1.71954092
156Abnormality of glycine metabolism (HP:0010895)1.71954092
157Abnormality of the vertebral endplates (HP:0005106)1.71673118
158Long toe (HP:0010511)1.69989313
159Disproportionate short-trunk short stature (HP:0003521)1.67675573
160Lethargy (HP:0001254)1.67364973
161Thin bony cortex (HP:0002753)1.66709614
162Increased circulating renin level (HP:0000848)1.65918575
163Abnormality of urine glucose concentration (HP:0011016)1.64519268
164Glycosuria (HP:0003076)1.64519268
165Protuberant abdomen (HP:0001538)1.63529500
166Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.60639099
167Tachypnea (HP:0002789)1.58603035
168Orthostatic hypotension (HP:0001278)1.58504914
169Myoglobinuria (HP:0002913)1.57147936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.11528901
2INSRR5.88433547
3PASK4.93476659
4TAOK34.21032816
5WNK33.50528077
6TLK13.27030448
7PRKD33.19256003
8HIPK23.04877558
9ERN12.83170920
10PHKG22.81129981
11PHKG12.81129981
12GRK12.75000602
13MAP3K22.71086261
14MAP4K22.67354994
15ADRBK22.65942650
16FRK2.44957302
17PINK12.26243433
18WNK42.20536932
19FLT32.01894220
20MAP2K61.98839154
21LIMK11.90372403
22DAPK21.85704444
23EPHA31.78361767
24TRIB31.77104338
25CSNK1G31.76947559
26MAP3K11.72551828
27CASK1.71504599
28LMTK21.69219577
29PIK3CG1.67994722
30BRAF1.54248341
31MST41.49579891
32LATS11.48863859
33NTRK11.44600543
34KSR21.41737821
35PTK2B1.40889621
36CSNK1G21.39606065
37CSNK1A1L1.37395776
38MST1R1.35469193
39FGFR21.35201831
40TESK11.34029422
41ACVR1B1.33526934
42SCYL21.31459084
43ZAK1.29130251
44PTK21.28576042
45OXSR11.28257191
46OBSCN1.27975342
47MAP2K71.26445149
48MAP2K21.26171667
49PDGFRA1.24996142
50MAP3K121.17656180
51STK391.17334929
52CDC42BPA1.16720395
53TRPM71.12400914
54TIE11.11439304
55PTK61.10090288
56PRKD21.09755682
57DYRK1B1.07357477
58IRAK11.07116418
59UHMK11.04282454
60NLK1.03217354
61ERBB41.00948269
62TNK20.97733050
63MAP3K40.94881039
64VRK20.93867915
65NME10.89944622
66BCKDK0.89814335
67MAPKAPK30.86317584
68MET0.85558607
69BRSK20.85534171
70ADRBK10.84554827
71RET0.81474836
72PAK30.80828144
73FGFR40.79270131
74MAP3K60.76903551
75PRKCH0.75739158
76IRAK30.75101403
77PRKCG0.73591574
78EPHA20.71429060
79STK38L0.70961323
80ABL20.70753591
81FER0.69593080
82GRK70.69297474
83STK30.68292240
84CDK80.66875805
85MAPK130.66262706
86PRKCI0.63249066
87PRKAA10.61974037
88DAPK10.61363314
89CAMKK20.61050464
90EIF2AK30.60002632
91MAP3K30.59060009
92MAP3K70.57213395
93MELK0.57107219
94MAP2K40.56896366
95JAK30.55132954
96EEF2K0.53696788
97JAK20.52052991
98TAOK10.51960247
99CDK90.50224930
100ITK0.49902833
101STK160.49673137
102ZAP700.49255929
103DYRK30.48160976
104MAP3K90.47751729
105MTOR0.47563224
106IKBKB0.47029844
107SIK10.45918116
108BMPR1B0.45260237
109STK380.44419505
110ERBB30.43655729
111CSNK1D0.42340744
112ARAF0.42248237
113MAP2K10.41206651
114BRSK10.41167499
115BMPR20.40771517
116PLK20.40723139
117PRKACA0.40468625
118CAMK2A0.40030550
119AKT30.39924577
120MARK20.39767268
121MUSK0.36835801
122PIK3CA0.36803336
123RIPK10.36475596
124NTRK30.35894245
125PRKCZ0.35339952
126STK110.34958734
127EPHB10.34476719
128DYRK20.33797762
129CHUK0.33700728
130PKN20.33207948
131WNK10.33138062
132MAP3K110.33012704
133PDGFRB0.31856821
134PRKCE0.31761715
135FGFR30.29942762
136PRKG10.29754604
137NUAK10.29027035
138MAPK110.26976929
139RPS6KA20.26809829
140CSNK1A10.26767575
141CAMK2D0.25259709
142PRKAA20.25187719
143PRKCA0.24990848
144PLK40.24655764
145PRKD10.24326752
146PRKACB0.24029386
147CAMK10.21647068
148IGF1R0.21161170
149CDK30.20738942
150GRK50.20662323
151GSK3A0.20141290
152KDR0.20045273
153BRD40.19861052
154MYLK0.19859774
155RPS6KB10.18405915
156CSK0.17504830
157PRKG20.16878796
158MOS0.16663156
159JAK10.15736508
160DYRK1A0.15020429
161MAPK140.15005951
162CSNK1G10.14886373

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.74717287
2Protein export_Homo sapiens_hsa030605.63412901
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.32487230
4Sulfur metabolism_Homo sapiens_hsa009203.28312614
5Insulin secretion_Homo sapiens_hsa049113.00725834
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17031717
7Type II diabetes mellitus_Homo sapiens_hsa049302.08093932
8Caffeine metabolism_Homo sapiens_hsa002321.99264720
9Vitamin B6 metabolism_Homo sapiens_hsa007501.95257587
10Vibrio cholerae infection_Homo sapiens_hsa051101.82406665
11Type I diabetes mellitus_Homo sapiens_hsa049401.79968822
12Peroxisome_Homo sapiens_hsa041461.79558824
13N-Glycan biosynthesis_Homo sapiens_hsa005101.74007955
14Circadian rhythm_Homo sapiens_hsa047101.70156416
15Selenocompound metabolism_Homo sapiens_hsa004501.68576452
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68093048
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.65328537
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.64805232
19Oxidative phosphorylation_Homo sapiens_hsa001901.63839542
20Folate biosynthesis_Homo sapiens_hsa007901.62621445
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.59802188
22Pancreatic secretion_Homo sapiens_hsa049721.59393196
23Nitrogen metabolism_Homo sapiens_hsa009101.57804053
24Cocaine addiction_Homo sapiens_hsa050301.55265043
25Propanoate metabolism_Homo sapiens_hsa006401.51710731
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47965195
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.47944822
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47942257
29Other glycan degradation_Homo sapiens_hsa005111.46165600
30Phototransduction_Homo sapiens_hsa047441.45643844
31Chemical carcinogenesis_Homo sapiens_hsa052041.45122880
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.43492767
33Retinol metabolism_Homo sapiens_hsa008301.40378678
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36677523
35Fatty acid elongation_Homo sapiens_hsa000621.36209645
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33826647
37Mineral absorption_Homo sapiens_hsa049781.24088742
38Prolactin signaling pathway_Homo sapiens_hsa049171.21659034
39Lysosome_Homo sapiens_hsa041421.21105136
40beta-Alanine metabolism_Homo sapiens_hsa004101.14643917
41Arachidonic acid metabolism_Homo sapiens_hsa005901.14083387
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13299107
43Glucagon signaling pathway_Homo sapiens_hsa049221.10848243
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08407541
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08136410
46Linoleic acid metabolism_Homo sapiens_hsa005911.07674106
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07547811
48Fatty acid metabolism_Homo sapiens_hsa012121.04627781
49Regulation of autophagy_Homo sapiens_hsa041401.03284982
50Tryptophan metabolism_Homo sapiens_hsa003801.01874175
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00679669
52Glycerolipid metabolism_Homo sapiens_hsa005611.00538613
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97912658
54Galactose metabolism_Homo sapiens_hsa000520.97323467
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95300551
56Thyroid hormone synthesis_Homo sapiens_hsa049180.95055538
57Parkinsons disease_Homo sapiens_hsa050120.93277452
58Ovarian steroidogenesis_Homo sapiens_hsa049130.93263302
59Insulin resistance_Homo sapiens_hsa049310.92423868
60Glutathione metabolism_Homo sapiens_hsa004800.92087652
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.91527305
62Fat digestion and absorption_Homo sapiens_hsa049750.86669876
63Amphetamine addiction_Homo sapiens_hsa050310.86591558
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86230127
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84791267
66Metabolic pathways_Homo sapiens_hsa011000.81004409
67Arginine biosynthesis_Homo sapiens_hsa002200.80039633
68Complement and coagulation cascades_Homo sapiens_hsa046100.79021733
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78800421
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77566177
71Cardiac muscle contraction_Homo sapiens_hsa042600.76229168
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75994568
73Bile secretion_Homo sapiens_hsa049760.75861381
74Salivary secretion_Homo sapiens_hsa049700.75320375
75Estrogen signaling pathway_Homo sapiens_hsa049150.72834664
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72333509
77ABC transporters_Homo sapiens_hsa020100.71939035
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71727932
79Alzheimers disease_Homo sapiens_hsa050100.71076231
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69867820
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69629322
82Taste transduction_Homo sapiens_hsa047420.68645255
83Prion diseases_Homo sapiens_hsa050200.68290972
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67671937
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.66757691
86Butanoate metabolism_Homo sapiens_hsa006500.65337536
87Sulfur relay system_Homo sapiens_hsa041220.65331142
88Thyroid cancer_Homo sapiens_hsa052160.62723333
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62006458
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61130714
91Insulin signaling pathway_Homo sapiens_hsa049100.60902796
92Fatty acid biosynthesis_Homo sapiens_hsa000610.60568363
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60312547
94Bladder cancer_Homo sapiens_hsa052190.57774915
95Vitamin digestion and absorption_Homo sapiens_hsa049770.55238484
96Protein digestion and absorption_Homo sapiens_hsa049740.54626235
97Starch and sucrose metabolism_Homo sapiens_hsa005000.54595244
98Histidine metabolism_Homo sapiens_hsa003400.53026933
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52864424
100Lysine degradation_Homo sapiens_hsa003100.52158142
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51966549
102Dorso-ventral axis formation_Homo sapiens_hsa043200.51771342
103Dopaminergic synapse_Homo sapiens_hsa047280.50994526
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50083710
105mTOR signaling pathway_Homo sapiens_hsa041500.49903249
106Sphingolipid metabolism_Homo sapiens_hsa006000.49247656
107One carbon pool by folate_Homo sapiens_hsa006700.48053479
108Serotonergic synapse_Homo sapiens_hsa047260.47138551
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.47019624
110PPAR signaling pathway_Homo sapiens_hsa033200.45353380
111Huntingtons disease_Homo sapiens_hsa050160.44453390
112Fatty acid degradation_Homo sapiens_hsa000710.43254656
113Cholinergic synapse_Homo sapiens_hsa047250.42659026
114GnRH signaling pathway_Homo sapiens_hsa049120.42536053
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41869369
116AMPK signaling pathway_Homo sapiens_hsa041520.39703051
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39117504
118Purine metabolism_Homo sapiens_hsa002300.38440479
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38087540
120RNA polymerase_Homo sapiens_hsa030200.36086216
121Inositol phosphate metabolism_Homo sapiens_hsa005620.35302314
122Long-term potentiation_Homo sapiens_hsa047200.35005759
123Ether lipid metabolism_Homo sapiens_hsa005650.34426466
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32829087
125Prostate cancer_Homo sapiens_hsa052150.31173575
126Antigen processing and presentation_Homo sapiens_hsa046120.31096977
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30876337
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.30800630
129FoxO signaling pathway_Homo sapiens_hsa040680.29636142
130RNA degradation_Homo sapiens_hsa030180.27649613
131Alcoholism_Homo sapiens_hsa050340.27610374
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26313932
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25936553
134Endometrial cancer_Homo sapiens_hsa052130.25623305
135Collecting duct acid secretion_Homo sapiens_hsa049660.25276853
136Circadian entrainment_Homo sapiens_hsa047130.25162018
137Phenylalanine metabolism_Homo sapiens_hsa003600.24193578
138Renal cell carcinoma_Homo sapiens_hsa052110.24182675
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21456214
140Pancreatic cancer_Homo sapiens_hsa052120.21330783
141cAMP signaling pathway_Homo sapiens_hsa040240.18633834
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17218141
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16513652
144GABAergic synapse_Homo sapiens_hsa047270.15941425
145Tyrosine metabolism_Homo sapiens_hsa003500.15680089
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.15498390
147Long-term depression_Homo sapiens_hsa047300.15282458
148Arginine and proline metabolism_Homo sapiens_hsa003300.13894505
149Fructose and mannose metabolism_Homo sapiens_hsa000510.13828191
150Renin secretion_Homo sapiens_hsa049240.13071594
151Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.10083485
152Choline metabolism in cancer_Homo sapiens_hsa052310.09449204
153Gastric acid secretion_Homo sapiens_hsa049710.06408662

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