RPIA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)5.73206314
2mitotic metaphase plate congression (GO:0007080)5.50087128
3negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.28725342
4regulation of establishment of cell polarity (GO:2000114)5.27667105
5nuclear pore complex assembly (GO:0051292)5.26130026
6DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla5.07429997
7mitotic chromosome condensation (GO:0007076)5.01493395
8regulation of RNA export from nucleus (GO:0046831)4.89177489
9meiotic chromosome segregation (GO:0045132)4.85947111
10DNA damage response, signal transduction resulting in transcription (GO:0042772)4.83965035
11regulation of transcription from RNA polymerase I promoter (GO:0006356)4.68916798
12protein localization to kinetochore (GO:0034501)4.67855035
13positive regulation of gamma-delta T cell activation (GO:0046645)4.63337262
14maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.54970519
15nuclear pore organization (GO:0006999)4.51820649
16histone lysine demethylation (GO:0070076)4.48318144
17histone demethylation (GO:0016577)4.46643458
18protein localization to chromosome, centromeric region (GO:0071459)4.45720822
19regulation of establishment or maintenance of cell polarity (GO:0032878)4.35790308
20metaphase plate congression (GO:0051310)4.35762041
21regulation of spindle organization (GO:0090224)4.29896289
22histone H3-K36 demethylation (GO:0070544)4.26915034
23DNA replication checkpoint (GO:0000076)4.25191828
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.24643122
25mitotic sister chromatid cohesion (GO:0007064)4.23452377
26negative regulation of DNA-dependent DNA replication (GO:2000104)4.19267775
27sphingosine metabolic process (GO:0006670)4.15020282
28sister chromatid cohesion (GO:0007062)4.13809476
29protein K6-linked ubiquitination (GO:0085020)4.12100080
30pore complex assembly (GO:0046931)4.06872737
31protein dealkylation (GO:0008214)4.04773888
32protein demethylation (GO:0006482)4.04773888
33inner cell mass cell proliferation (GO:0001833)4.01216999
34regulation of retinoic acid receptor signaling pathway (GO:0048385)3.96196179
35snRNA transcription (GO:0009301)3.95034396
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.91520434
37diol metabolic process (GO:0034311)3.91166223
38response to UV-C (GO:0010225)3.90779743
39microtubule depolymerization (GO:0007019)3.84402720
40regulation of nucleobase-containing compound transport (GO:0032239)3.82792557
413-UTR-mediated mRNA stabilization (GO:0070935)3.77364904
42establishment of chromosome localization (GO:0051303)3.73431632
43mitotic sister chromatid segregation (GO:0000070)3.71278044
44regulation of meiosis I (GO:0060631)3.58869134
45protein localization to chromosome (GO:0034502)3.57161773
46histone H2A monoubiquitination (GO:0035518)3.57120137
47positive regulation of B cell differentiation (GO:0045579)3.55304133
48positive regulation of granulocyte differentiation (GO:0030854)3.52012140
49histone H3-K9 demethylation (GO:0033169)3.51350907
50regulation of double-strand break repair via homologous recombination (GO:0010569)3.51215652
51positive regulation of chromosome segregation (GO:0051984)3.50995715
52protoporphyrinogen IX metabolic process (GO:0046501)3.47167352
53regulation of gamma-delta T cell differentiation (GO:0045586)3.44874691
54positive regulation of mitotic sister chromatid separation (GO:1901970)3.42563495
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.42563495
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.42563495
57negative regulation of cell aging (GO:0090344)3.41033026
58mitotic nuclear envelope disassembly (GO:0007077)3.40707133
59oocyte maturation (GO:0001556)3.38360568
60regulation of mitotic spindle organization (GO:0060236)3.36513908
61regulation of B cell receptor signaling pathway (GO:0050855)3.33560308
62DNA synthesis involved in DNA repair (GO:0000731)3.31838021
63DNA unwinding involved in DNA replication (GO:0006268)3.28822085
64cellular response to gamma radiation (GO:0071480)3.28339677
65regulation of sister chromatid cohesion (GO:0007063)3.28108430
66negative regulation of erythrocyte differentiation (GO:0045647)3.27530527
67sister chromatid segregation (GO:0000819)3.26373956
68sphingoid metabolic process (GO:0046519)3.23751837
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22855940
70kinetochore assembly (GO:0051382)3.22852219
71negative thymic T cell selection (GO:0045060)3.22185163
72regulation of gamma-delta T cell activation (GO:0046643)3.21595794
73kinetochore organization (GO:0051383)3.19249196
74meiosis I (GO:0007127)3.18469516
75chromosome segregation (GO:0007059)3.18333948
76negative T cell selection (GO:0043383)3.17925192
77male meiosis I (GO:0007141)3.11979719
78corticosteroid receptor signaling pathway (GO:0031958)3.09649298
79regulation of keratinocyte proliferation (GO:0010837)3.09590897
80membrane disassembly (GO:0030397)3.09561887
81nuclear envelope disassembly (GO:0051081)3.09561887
82DNA replication-independent nucleosome organization (GO:0034724)3.08864187
83DNA replication-independent nucleosome assembly (GO:0006336)3.08864187
84replication fork processing (GO:0031297)3.08780062
85DNA damage induced protein phosphorylation (GO:0006975)3.06058860
86positive thymic T cell selection (GO:0045059)3.04839314
87regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.03359343
88regulation of hippo signaling (GO:0035330)3.02492062
89regulation of exit from mitosis (GO:0007096)2.99499502
90regulation of B cell differentiation (GO:0045577)2.99270117
91N-terminal protein amino acid acetylation (GO:0006474)2.98326305
92resolution of meiotic recombination intermediates (GO:0000712)2.96707073
93microtubule nucleation (GO:0007020)2.96060996
94formation of translation preinitiation complex (GO:0001731)2.94786437
95positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93394626
96tolerance induction (GO:0002507)2.93102059
97antigen processing and presentation of endogenous antigen (GO:0019883)2.93066911
98negative regulation of DNA replication (GO:0008156)2.92627219
99positive regulation of protein import into nucleus, translocation (GO:0033160)2.91976119
100female gonad development (GO:0008585)2.91189733
101negative regulation of keratinocyte proliferation (GO:0010839)2.89648314
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89589914
103histone exchange (GO:0043486)2.89475797
104paraxial mesoderm development (GO:0048339)2.88942253
105negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.88335221
106negative regulation of cell killing (GO:0031342)2.88335221
107DNA strand elongation involved in DNA replication (GO:0006271)2.87928282
108B cell receptor signaling pathway (GO:0050853)2.87862358
109regulation of double-strand break repair (GO:2000779)2.86903904
110poly(A)+ mRNA export from nucleus (GO:0016973)2.85687861
111thymic T cell selection (GO:0045061)2.84132624
112regulation of chromosome segregation (GO:0051983)2.83644671
113CENP-A containing nucleosome assembly (GO:0034080)2.83606616
114response to interleukin-15 (GO:0070672)2.81024876
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80906482
116DNA strand elongation (GO:0022616)2.79540389
117dosage compensation (GO:0007549)2.79057633
118leukocyte aggregation (GO:0070486)2.78366425
119spindle checkpoint (GO:0031577)2.78057537
120Peyers patch development (GO:0048541)2.76907960
121mucosal-associated lymphoid tissue development (GO:0048537)2.76907960
122regulation of chromatin silencing (GO:0031935)2.75607514
123chromatin remodeling at centromere (GO:0031055)2.75048701
124T cell selection (GO:0045058)2.74831851
125histone H3-K9 methylation (GO:0051567)2.74705779
126chromatin assembly or disassembly (GO:0006333)2.73023920
127regulation of DNA-dependent DNA replication (GO:0090329)2.72632621
128attachment of spindle microtubules to kinetochore (GO:0008608)2.72341756
129antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71692974
130telomere maintenance via semi-conservative replication (GO:0032201)2.71187260
131histone H3-K4 methylation (GO:0051568)2.70865581
132reciprocal DNA recombination (GO:0035825)2.69710682
133reciprocal meiotic recombination (GO:0007131)2.69710682
134positive T cell selection (GO:0043368)2.69384885
135megakaryocyte development (GO:0035855)2.68346504
136nucleus organization (GO:0006997)2.67732059
137negative regulation of T cell mediated immunity (GO:0002710)2.67570973
138negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67449983
139protoporphyrinogen IX biosynthetic process (GO:0006782)2.66100874
140hepatocyte apoptotic process (GO:0097284)2.64513429
141folic acid-containing compound biosynthetic process (GO:0009396)2.59845051
142DNA topological change (GO:0006265)2.59777642
143NIK/NF-kappaB signaling (GO:0038061)2.58101008
144cellular response to interleukin-4 (GO:0071353)2.57776220
145ribosomal small subunit biogenesis (GO:0042274)2.56856004
146regulation of granulocyte differentiation (GO:0030852)2.56544149
147neutrophil activation involved in immune response (GO:0002283)2.53665388
148positive regulation of isotype switching (GO:0045830)2.52805086
149modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.51339931
150positive regulation by organism of defense response of other organism involved in symbiotic interact2.51339931
151modulation by symbiont of host immune response (GO:0052553)2.51339931
152positive regulation by symbiont of host defense response (GO:0052509)2.51339931
153modulation by symbiont of host defense response (GO:0052031)2.51339931
154modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.51339931
155erythrocyte development (GO:0048821)2.50559776
156deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.49540133
157response to peptidoglycan (GO:0032494)2.49068731
158RNA stabilization (GO:0043489)2.47706656
159mRNA stabilization (GO:0048255)2.47706656
160cellular extravasation (GO:0045123)2.47354345
161telomere maintenance via recombination (GO:0000722)2.44491325
162regulation of interleukin-2 biosynthetic process (GO:0045076)2.40368078
163regulation of histone H3-K27 methylation (GO:0061085)2.38528961
164Arp2/3 complex-mediated actin nucleation (GO:0034314)2.38371497
165cellular hyperosmotic response (GO:0071474)2.38236271
166IMP biosynthetic process (GO:0006188)2.37788670
167DNA replication initiation (GO:0006270)2.36360239
168necroptotic process (GO:0070266)2.34830367
169myeloid dendritic cell activation (GO:0001773)2.33483102
170V(D)J recombination (GO:0033151)2.33473760
171negative regulation of phagocytosis (GO:0050765)2.33256148
172regulation of alpha-beta T cell proliferation (GO:0046640)2.32579949
173viral mRNA export from host cell nucleus (GO:0046784)2.31714747
174programmed necrotic cell death (GO:0097300)2.31510500
175negative regulation of RNA splicing (GO:0033119)2.31170570
176pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.31118994
177natural killer cell differentiation (GO:0001779)2.31088006
178cellular response to interleukin-15 (GO:0071350)2.30235845
179positive regulation of alpha-beta T cell proliferation (GO:0046641)2.29981419
180ribosome biogenesis (GO:0042254)2.29366637
181negative regulation of necroptotic process (GO:0060546)2.26532284
182mitotic recombination (GO:0006312)2.26351399
183response to interleukin-4 (GO:0070670)2.25871144
184maturation of SSU-rRNA (GO:0030490)2.25664580
185response to protozoan (GO:0001562)2.25515521
186defense response to protozoan (GO:0042832)2.22804863
187regulation of isotype switching to IgG isotypes (GO:0048302)2.22601368
188DNA ligation (GO:0006266)2.21820812
189T cell homeostasis (GO:0043029)2.21701316
190negative regulation of mRNA processing (GO:0050686)2.21597520
191oxygen transport (GO:0015671)2.21439165
192detection of bacterium (GO:0016045)2.21143591
193IMP metabolic process (GO:0046040)2.20882646
194myeloid cell development (GO:0061515)2.20663283
195positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.20525199

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.38382525
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.26844971
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.92778517
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.65860892
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59172797
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52982553
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.31820928
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.22230178
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.76678691
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.69093854
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.52710780
12* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45206370
13AR_21909140_ChIP-Seq_LNCAP_Human2.36100872
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.34541476
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.26073008
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.19447577
17KAP1_22055183_ChIP-Seq_ESCs_Mouse2.11043706
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.06343705
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04379978
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.00466802
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.98502090
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95621274
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.92223298
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91693207
25MYC_22102868_ChIP-Seq_BL_Human1.91067429
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86471190
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82622464
28GATA1_22025678_ChIP-Seq_K562_Human1.74659333
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68961617
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66554439
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63020070
32VDR_24763502_ChIP-Seq_THP-1_Human1.60718307
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58088904
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56965231
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56491669
36KDM5A_27292631_Chip-Seq_BREAST_Human1.55057092
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.51306490
38MAF_26560356_Chip-Seq_TH2_Human1.50543456
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49470529
40DCP1A_22483619_ChIP-Seq_HELA_Human1.48602725
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.48469619
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47825641
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46837042
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41853210
45* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40977185
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40425240
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40327026
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39971593
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39855777
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39696371
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39649590
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37752618
53* VDR_23849224_ChIP-Seq_CD4+_Human1.36762863
54* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36275996
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36090327
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35552601
57* GABP_19822575_ChIP-Seq_HepG2_Human1.34265279
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33547361
59* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31811595
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27022684
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26674586
62MYB_26560356_Chip-Seq_TH1_Human1.26642126
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25614607
64* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23632631
65MYC_18555785_ChIP-Seq_MESCs_Mouse1.23301088
66NCOR1_26117541_ChIP-Seq_K562_Human1.21610984
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21444653
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21263938
69SCL_19346495_ChIP-Seq_HPC-7_Human1.21098796
70TFEB_21752829_ChIP-Seq_HELA_Human1.19643886
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19484922
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18753031
73* FOXP3_21729870_ChIP-Seq_TREG_Human1.17611656
74E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16982893
75PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15964760
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15761913
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15504276
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15147916
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14764268
80TTF2_22483619_ChIP-Seq_HELA_Human1.14024739
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13804177
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13354657
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.12763041
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12314270
85RUNX_20019798_ChIP-Seq_JUKART_Human1.12076694
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12029804
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11124229
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10741795
89STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09419154
90MYC_18940864_ChIP-ChIP_HL60_Human1.09177585
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09010683
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.08983211
93UTX_26944678_Chip-Seq_JUKART_Human1.08550064
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07261716
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07186664
96SPI1_23547873_ChIP-Seq_NB4_Human1.06876212
97TCF7_22412390_ChIP-Seq_EML_Mouse1.04830575
98* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04213873
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04094906
100* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03907669
101MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03887254
102CIITA_25753668_ChIP-Seq_RAJI_Human1.02856622
103MYB_26560356_Chip-Seq_TH2_Human1.02427103
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01018946
105IRF8_21731497_ChIP-ChIP_J774_Mouse0.99890122
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99364383
107* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95550596
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94747753
109VDR_21846776_ChIP-Seq_THP-1_Human0.94540298
110CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94020164
111SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93065707
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92963112
113XRN2_22483619_ChIP-Seq_HELA_Human0.91490591
114FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91233009
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89473058
116FUS_26573619_Chip-Seq_HEK293_Human0.89394267
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.89095584
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88708046
119IGF1R_20145208_ChIP-Seq_DFB_Human0.88556317
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87377099
121ELK1_19687146_ChIP-ChIP_HELA_Human0.86055446
122GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85614500
123* EST1_17652178_ChIP-ChIP_JURKAT_Human0.84977960
124POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84200729
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84177798
126RUNX1_22412390_ChIP-Seq_EML_Mouse0.84059058
127RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83592626
128* ETS1_20019798_ChIP-Seq_JURKAT_Human0.83524416
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81948181
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81053490
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.79580685
132VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79265973
133MAF_26560356_Chip-Seq_TH1_Human0.78186148
134ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75810121
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73796373
136BRD4_27068464_Chip-Seq_AML-cells_Mouse0.73267864

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.37984514
2MP0003693_abnormal_embryo_hatching4.24441906
3MP0003111_abnormal_nucleus_morphology3.54139687
4MP0003077_abnormal_cell_cycle3.42983118
5MP0008007_abnormal_cellular_replicative3.25499919
6MP0010094_abnormal_chromosome_stability3.11392737
7MP0002396_abnormal_hematopoietic_system2.95615131
8MP0005451_abnormal_body_composition2.94220433
9MP0003436_decreased_susceptibility_to2.71512934
10MP0008058_abnormal_DNA_repair2.69738162
11MP0000685_abnormal_immune_system2.56101406
12MP0006292_abnormal_olfactory_placode2.49189285
13MP0010307_abnormal_tumor_latency2.48859627
14MP0008877_abnormal_DNA_methylation2.40235100
15MP0003656_abnormal_erythrocyte_physiolo2.26692354
16MP0002877_abnormal_melanocyte_morpholog2.19714931
17MP0004957_abnormal_blastocyst_morpholog2.16411895
18MP0008260_abnormal_autophagy2.14897415
19MP0005000_abnormal_immune_tolerance2.13614259
20MP0005464_abnormal_platelet_physiology2.11894540
21MP0009333_abnormal_splenocyte_physiolog1.98738899
22MP0000350_abnormal_cell_proliferation1.98281655
23MP0000566_synostosis1.94051051
24MP0000490_abnormal_crypts_of1.91202454
25MP0001873_stomach_inflammation1.90942604
26MP0005397_hematopoietic_system_phenotyp1.90916056
27MP0001545_abnormal_hematopoietic_system1.90916056
28MP0003787_abnormal_imprinting1.90594430
29MP0005025_abnormal_response_to1.87353923
30MP0004808_abnormal_hematopoietic_stem1.78529992
31MP0002419_abnormal_innate_immunity1.76313259
32MP0003763_abnormal_thymus_physiology1.72930075
33MP0001730_embryonic_growth_arrest1.69767157
34MP0009785_altered_susceptibility_to1.69507669
35MP0005408_hypopigmentation1.64069836
36MP0002148_abnormal_hypersensitivity_rea1.52368922
37MP0004947_skin_inflammation1.50784263
38MP0003724_increased_susceptibility_to1.47952465
39MP0005380_embryogenesis_phenotype1.46302773
40MP0001672_abnormal_embryogenesis/_devel1.46302773
41MP0008995_early_reproductive_senescence1.45779070
42MP0005310_abnormal_salivary_gland1.43992570
43MP0003890_abnormal_embryonic-extraembry1.39492093
44MP0005076_abnormal_cell_differentiation1.38887538
45MP0003718_maternal_effect1.38793652
46MP0010155_abnormal_intestine_physiology1.35652397
47MP0002163_abnormal_gland_morphology1.35122595
48MP0002102_abnormal_ear_morphology1.33024060
49MP0005075_abnormal_melanosome_morpholog1.32129106
50MP0003300_gastrointestinal_ulcer1.31616343
51MP0002398_abnormal_bone_marrow1.31464180
52MP0002210_abnormal_sex_determination1.29411448
53MP0003303_peritoneal_inflammation1.29024392
54MP0002277_abnormal_respiratory_mucosa1.27095255
55MP0003984_embryonic_growth_retardation1.27004538
56MP0001845_abnormal_inflammatory_respons1.26678136
57MP0001853_heart_inflammation1.26318562
58MP0004147_increased_porphyrin_level1.25673978
59MP0004264_abnormal_extraembryonic_tissu1.24334961
60MP0003866_abnormal_defecation1.23794330
61MP0003937_abnormal_limbs/digits/tail_de1.22328933
62MP0004185_abnormal_adipocyte_glucose1.22324215
63MP0001929_abnormal_gametogenesis1.22277674
64MP0002132_abnormal_respiratory_system1.20736668
65MP0002084_abnormal_developmental_patter1.20168881
66MP0002088_abnormal_embryonic_growth/wei1.19146291
67MP0002085_abnormal_embryonic_tissue1.18359306
68MP0001119_abnormal_female_reproductive1.17921628
69MP0002019_abnormal_tumor_incidence1.17199797
70MP0000858_altered_metastatic_potential1.16883107
71MP0003786_premature_aging1.16752454
72MP0001697_abnormal_embryo_size1.15815912
73MP0009278_abnormal_bone_marrow1.11914476
74MP0001800_abnormal_humoral_immune1.09524540
75MP0001851_eye_inflammation1.08362280
76MP0005671_abnormal_response_to1.07325865
77MP0006036_abnormal_mitochondrial_physio1.06935867
78MP0001835_abnormal_antigen_presentation1.06672545
79MP0000653_abnormal_sex_gland1.05873742
80MP0000689_abnormal_spleen_morphology1.04980517
81MP0002086_abnormal_extraembryonic_tissu1.04863191
82MP0000703_abnormal_thymus_morphology1.03612079
83MP0008932_abnormal_embryonic_tissue1.03330336
84MP0002722_abnormal_immune_system1.02707048
85MP0000313_abnormal_cell_death1.02395267
86MP0001986_abnormal_taste_sensitivity1.01405830
87MP0001145_abnormal_male_reproductive1.00534031
88MP0008789_abnormal_olfactory_epithelium0.96426739
89MP0003172_abnormal_lysosome_physiology0.96047807
90MP0002006_tumorigenesis0.95974946
91MP0005647_abnormal_sex_gland0.94797509
92MP0000716_abnormal_immune_system0.94382835
93MP0002405_respiratory_system_inflammati0.93903286
94MP0002009_preneoplasia0.93530051
95MP0004381_abnormal_hair_follicle0.91741001
96MP0002080_prenatal_lethality0.91717372
97MP0008469_abnormal_protein_level0.91679006
98MP0003699_abnormal_female_reproductive0.91633767
99MP0002653_abnormal_ependyma_morphology0.89433718
100MP0000627_abnormal_mammary_gland0.88071542
101MP0003121_genomic_imprinting0.88014492
102MP0002420_abnormal_adaptive_immunity0.87594835
103MP0002452_abnormal_antigen_presenting0.86735919
104MP0005501_abnormal_skin_physiology0.86144451
105MP0001819_abnormal_immune_cell0.85869938
106MP0005058_abnormal_lysosome_morphology0.85221569
107MP0006035_abnormal_mitochondrial_morpho0.84783979
108MP0002166_altered_tumor_susceptibility0.84678235
109MP0005220_abnormal_exocrine_pancreas0.84667396
110MP0002429_abnormal_blood_cell0.84155790
111MP0001533_abnormal_skeleton_physiology0.84028552
112MP0009672_abnormal_birth_weight0.83723221
113MP0002138_abnormal_hepatobiliary_system0.83574769
114MP0010352_gastrointestinal_tract_polyps0.82805233
115MP0003123_paternal_imprinting0.82010213
116MP0005621_abnormal_cell_physiology0.81722196
117MP0005248_abnormal_Harderian_gland0.80998710
118MP0003221_abnormal_cardiomyocyte_apopto0.80400672
119MP0003191_abnormal_cellular_cholesterol0.78249775
120MP0002723_abnormal_immune_serum0.76892839
121MP0000465_gastrointestinal_hemorrhage0.76665249
122MP0003806_abnormal_nucleotide_metabolis0.75331659
123MP0001663_abnormal_digestive_system0.74862296
124MP0001790_abnormal_immune_system0.73454459
125MP0005387_immune_system_phenotype0.73454459
126MP0000613_abnormal_salivary_gland0.72497799
127MP0000609_abnormal_liver_physiology0.71351054
128MP0009763_increased_sensitivity_to0.71001245
129MP0001346_abnormal_lacrimal_gland0.70835936
130MP0003186_abnormal_redox_activity0.70616635
131MP0003828_pulmonary_edema0.70139272
132MP0005379_endocrine/exocrine_gland_phen0.69907438
133MP0003935_abnormal_craniofacial_develop0.68982638
134MP0005083_abnormal_biliary_tract0.68065293
135MP0001915_intracranial_hemorrhage0.66372164
136MP0003315_abnormal_perineum_morphology0.65944216
137MP0003755_abnormal_palate_morphology0.62706755

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.87336472
2Chromsome breakage (HP:0040012)5.61181552
3Prostate neoplasm (HP:0100787)5.37823059
4Facial hemangioma (HP:0000329)4.66429441
5Papillary thyroid carcinoma (HP:0002895)4.65948042
6Abnormality of the fingertips (HP:0001211)4.24206287
7Acute myeloid leukemia (HP:0004808)3.97767815
8Capillary hemangiomas (HP:0005306)3.92229657
9Abnormality of chromosome stability (HP:0003220)3.84695490
10Birth length less than 3rd percentile (HP:0003561)3.84516001
11Abnormality of the preputium (HP:0100587)3.83968932
12Recurrent bacterial skin infections (HP:0005406)3.68087166
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.62914356
14Meckel diverticulum (HP:0002245)3.55810504
15Eczematoid dermatitis (HP:0000976)3.54580441
16Recurrent abscess formation (HP:0002722)3.52015699
17Abnormality of the prostate (HP:0008775)3.50584196
18Lip pit (HP:0100267)3.43370606
19Prolonged bleeding time (HP:0003010)3.38432408
20Abnormality of the ileum (HP:0001549)3.33522071
21Myelodysplasia (HP:0002863)3.32636335
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.28398802
23Ectopic kidney (HP:0000086)3.26305762
24Cholecystitis (HP:0001082)3.21862380
25Abnormal gallbladder physiology (HP:0012438)3.21862380
26Chronic obstructive pulmonary disease (HP:0006510)3.19449909
27Obstructive lung disease (HP:0006536)3.19449909
28Panhypogammaglobulinemia (HP:0003139)3.16966540
29Patellar aplasia (HP:0006443)3.07747390
30Abnormality of T cells (HP:0002843)3.07731994
31Petechiae (HP:0000967)3.04516087
32Abnormality of T cell physiology (HP:0011840)3.04065352
33Meningitis (HP:0001287)3.00030567
34Clubbing of toes (HP:0100760)2.98202975
35Acute lymphatic leukemia (HP:0006721)2.95428225
36Stomatitis (HP:0010280)2.93113169
37Encephalitis (HP:0002383)2.89159114
38Aplasia/Hypoplasia of the patella (HP:0006498)2.85051693
39Thrombocytosis (HP:0001894)2.83333329
40T lymphocytopenia (HP:0005403)2.83198016
41Volvulus (HP:0002580)2.81054246
42Myositis (HP:0100614)2.79345164
43Abnormality of the carotid arteries (HP:0005344)2.79194165
44Thyroid carcinoma (HP:0002890)2.78155011
45Prominent nose (HP:0000448)2.77816441
46Mediastinal lymphadenopathy (HP:0100721)2.77704441
47Hypertensive crisis (HP:0100735)2.77247455
48Elevated erythrocyte sedimentation rate (HP:0003565)2.76432388
49Hypochromic microcytic anemia (HP:0004840)2.71598417
50Aplasia/Hypoplasia of the thymus (HP:0010515)2.66736078
51Microcytic anemia (HP:0001935)2.66243369
52Small intestinal stenosis (HP:0012848)2.64759277
53Duodenal stenosis (HP:0100867)2.64759277
54Gastrointestinal infarctions (HP:0005244)2.64318988
55Poikilocytosis (HP:0004447)2.62954016
56Epistaxis (HP:0000421)2.61349915
57Autoimmune hemolytic anemia (HP:0001890)2.61240308
58Progressive muscle weakness (HP:0003323)2.60680599
59Recurrent skin infections (HP:0001581)2.60679446
60Shawl scrotum (HP:0000049)2.59465040
61Abnormality of the labia minora (HP:0012880)2.55857775
62Abnormality of T cell number (HP:0011839)2.53418956
63Abnormality of male internal genitalia (HP:0000022)2.53205376
64Cellulitis (HP:0100658)2.51995143
65Gastrointestinal inflammation (HP:0004386)2.51787934
66Long eyelashes (HP:0000527)2.50379574
67Vasculitis (HP:0002633)2.47805605
68Lymphopenia (HP:0001888)2.47118277
69Increased IgM level (HP:0003496)2.46981431
70Microvesicular hepatic steatosis (HP:0001414)2.45658476
71IgG deficiency (HP:0004315)2.45269369
72Autoimmune thrombocytopenia (HP:0001973)2.43655218
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.42359581
74Abnormality of macrophages (HP:0004311)2.42073664
75Granulocytopenia (HP:0001913)2.40579067
76Viral hepatitis (HP:0006562)2.40228707
77Lymphoma (HP:0002665)2.38324793
78Gastrointestinal stroma tumor (HP:0100723)2.36088048
79Hypochromic anemia (HP:0001931)2.34583797
80Osteomyelitis (HP:0002754)2.34307091
81Progressive external ophthalmoplegia (HP:0000590)2.33771231
82Urticaria (HP:0001025)2.33634481
83Azoospermia (HP:0000027)2.33368078
84Pustule (HP:0200039)2.33245636
85Inflammation of the large intestine (HP:0002037)2.31593284
86Short thumb (HP:0009778)2.29426710
87IgA deficiency (HP:0002720)2.28772589
88Hepatosplenomegaly (HP:0001433)2.28565318
89Abnormal platelet volume (HP:0011876)2.28553309
90Spontaneous hematomas (HP:0007420)2.28440777
91Cholelithiasis (HP:0001081)2.24689997
92Bone marrow hypocellularity (HP:0005528)2.23203225
93Orchitis (HP:0100796)2.21058503
94Male infertility (HP:0003251)2.20897249
95Orthostatic hypotension (HP:0001278)2.20717983
96Overlapping toe (HP:0001845)2.19193846
97Slow saccadic eye movements (HP:0000514)2.19027128
98Retrobulbar optic neuritis (HP:0100654)2.18840848
99Optic neuritis (HP:0100653)2.18840848
100Pallor (HP:0000980)2.17904804
101Oligodactyly (HP:0012165)2.17829037
102Reticulocytosis (HP:0001923)2.15967576
103Entropion (HP:0000621)2.14683176
104Colitis (HP:0002583)2.13481175
105Chest pain (HP:0100749)2.12626898
106Abnormal spermatogenesis (HP:0008669)2.12469967
107Oligodactyly (hands) (HP:0001180)2.11134944
108Nephroblastoma (Wilms tumor) (HP:0002667)2.08583437
109Thoracolumbar scoliosis (HP:0002944)2.07937952
110Abnormal platelet function (HP:0011869)2.07754152
111Impaired platelet aggregation (HP:0003540)2.07754152
112Adrenal hypoplasia (HP:0000835)2.07510555
113Abnormality of the duodenum (HP:0002246)2.06871165
114Abnormal delayed hypersensitivity skin test (HP:0002963)2.06467342
115Ragged-red muscle fibers (HP:0003200)2.06322192
116Flat capital femoral epiphysis (HP:0003370)2.06251894
117Seborrheic dermatitis (HP:0001051)2.05931343
118Impulsivity (HP:0100710)2.03900133
119Papilloma (HP:0012740)2.03763612
120Verrucae (HP:0200043)2.03763612
121Cafe-au-lait spot (HP:0000957)2.03558667
122Sparse lateral eyebrow (HP:0005338)2.01303064
123Abnormality of the thymus (HP:0000777)2.00540968
124Severe combined immunodeficiency (HP:0004430)1.99451745
125Abnormality of chromosome segregation (HP:0002916)1.97906125
126Acute hepatic failure (HP:0006554)1.97329203
127Abnormality of reticulocytes (HP:0004312)1.97304880
128Gingival bleeding (HP:0000225)1.97074918
129Abnormality of DNA repair (HP:0003254)1.95346455
130Breast aplasia (HP:0100783)1.95147117
131Recurrent bronchitis (HP:0002837)1.94984343
132Increased mean platelet volume (HP:0011877)1.94376117
133Combined immunodeficiency (HP:0005387)1.93975727
134Urethral obstruction (HP:0000796)1.93299956
135Arteriovenous malformation (HP:0100026)1.92772108
136Abnormality of the columella (HP:0009929)1.92547079
137Amaurosis fugax (HP:0100576)1.92349193
138Abnormality of cells of the erythroid lineage (HP:0012130)1.91521238
139Abnormality of the hepatic vasculature (HP:0006707)1.91238934
140Chronic diarrhea (HP:0002028)1.90178299
141Keratoconjunctivitis sicca (HP:0001097)1.89782925
142Abnormality of lateral ventricle (HP:0030047)1.87617623
143Microtia (HP:0008551)1.86527860
144Abnormal gallbladder morphology (HP:0012437)1.86281869
145Leukocytosis (HP:0001974)1.85889737
146Embryonal renal neoplasm (HP:0011794)1.85682793
147Anal stenosis (HP:0002025)1.85429278
148Breast hypoplasia (HP:0003187)1.85257973
149Tracheoesophageal fistula (HP:0002575)1.84162746
150Sloping forehead (HP:0000340)1.82702945
151Polycythemia (HP:0001901)1.82482794
152Ectropion (HP:0000656)1.78869835
153Squamous cell carcinoma (HP:0002860)1.78525234
154Recurrent viral infections (HP:0004429)1.77947465
155Triphalangeal thumb (HP:0001199)1.77269991
156Aplasia/Hypoplasia of the breasts (HP:0010311)1.73586921
157Anal atresia (HP:0002023)1.73377588
158Ureteral obstruction (HP:0006000)1.72584639
159Hypoplasia of the fovea (HP:0007750)1.72172666
160Aplasia/Hypoplasia of the fovea (HP:0008060)1.72172666
161Microglossia (HP:0000171)1.71070759
162Poikiloderma (HP:0001029)1.69738088
163Arterial thrombosis (HP:0004420)1.68281659
164Transitional cell carcinoma of the bladder (HP:0006740)1.68230899
165Ureteral stenosis (HP:0000071)1.67828237
166Thyroiditis (HP:0100646)1.66768744
167Blepharitis (HP:0000498)1.66111468
168Coarctation of aorta (HP:0001680)1.65288529
169Hypoplastic iliac wings (HP:0002866)1.64155594
170Abnormality of the heme biosynthetic pathway (HP:0010472)1.63836090
171Fatigue (HP:0012378)1.62552590
172IgM deficiency (HP:0002850)1.62461827
173Recurrent fungal infections (HP:0002841)1.62276759
174Heterotopia (HP:0002282)1.61580667
175Recurrent cutaneous fungal infections (HP:0011370)1.59920067
176Chronic mucocutaneous candidiasis (HP:0002728)1.59920067
177Spontaneous abortion (HP:0005268)1.59414960
178Agammaglobulinemia (HP:0004432)1.57533103
179Leukopenia (HP:0001882)1.57251867
180Abnormality of the line of Schwalbe (HP:0008048)1.57143188
181Horseshoe kidney (HP:0000085)1.56934191
182Truncal obesity (HP:0001956)1.55457705
183Carpal bone hypoplasia (HP:0001498)1.54440790

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS17.85689557
2STK38L5.69131027
3LATS25.46576189
4CDC73.32168103
5STK33.05633285
6PRPF4B3.01824455
7SMG12.71471594
8RIPK42.66847230
9CDK122.66609744
10NEK22.16676927
11SRPK12.08272302
12MAP3K142.05467890
13MAP3K132.04116521
14GRK61.94273381
15TAOK31.93479485
16TAOK21.89548591
17MAP3K101.77959118
18NME21.64301328
19PLK41.63164110
20STK381.60880170
21CHEK21.55886129
22JAK31.54323819
23ERN11.54165954
24VRK21.50693320
25BTK1.47551538
26TTK1.44706230
27TAOK11.42277096
28ABL21.39125546
29BRSK21.33030859
30SYK1.30291772
31DYRK31.29887734
32EEF2K1.29778468
33MAP4K11.29633297
34FRK1.27274662
35MKNK21.26324957
36MAP3K61.25929688
37CDK81.25738818
38BLK1.23535000
39IKBKE1.22187570
40PLK11.20716813
41CSK1.19909958
42PASK1.19671382
43TESK21.17949783
44FES1.16024443
45AURKB1.13277715
46WEE11.12565009
47CHEK11.11312248
48ERBB41.11005083
49CAMK1D1.10991452
50MAP3K111.08480077
51MST41.06259861
52STK241.01867628
53PDGFRB1.00933379
54SIK31.00536188
55CDK41.00384949
56BUB10.98000344
57CDK90.97800633
58NUAK10.97257403
59FGR0.97167777
60ATM0.97122858
61TBK10.96780153
62CDK70.96759787
63ITK0.96344304
64IRAK30.89919380
65PIM10.89346718
66LYN0.88279729
67MAP3K10.87930139
68LRRK20.87465368
69VRK10.87065143
70TRIB30.85106248
71ATR0.84839532
72MELK0.83526272
73STK40.83046257
74SCYL20.82902646
75STK100.82477982
76FGFR40.81299931
77KDR0.81087184
78CDK30.80461928
79MATK0.80294552
80CSF1R0.78956785
81RAF10.77849392
82RPS6KB20.76677100
83ABL10.76562198
84PLK30.75981633
85BRD40.75303021
86ZAK0.73534375
87ICK0.73472622
88LCK0.71316040
89ACVR1B0.67268766
90EIF2AK30.66586631
91TAF10.65748579
92CCNB10.65238788
93ARAF0.62769535
94BRSK10.61211155
95HIPK20.60458636
96TEC0.59792719
97CDK20.59612685
98MAP3K30.59136579
99CHUK0.58373113
100CAMK1G0.57567099
101STK160.56945583
102MARK30.56775413
103PRKD20.55368473
104TNK20.54976587
105IRAK40.54684412
106JAK10.54423936
107BRAF0.54359841
108MKNK10.52930719
109PRKAA10.52234353
110PRKAA20.51153454
111BMPR20.51125434
112MAPKAPK20.51029981
113MAP3K50.50515722
114SIK10.49678214
115MAP2K20.49250342
116CDK190.48421430
117YES10.47975158
118IRAK20.47460723
119MAPK100.46341903
120MOS0.46223077
121CDK10.46216768
122IRAK10.43973671
123TXK0.43036610
124DAPK10.42516260
125CDK60.41973549
126IKBKB0.41831992
127MAP3K80.41738330
128DYRK20.41301934
129DMPK0.40280557
130EPHA30.40269219
131EIF2AK20.40171602
132ALK0.39692763
133EIF2AK10.39090297
134HCK0.37080916
135RPS6KA40.35064448
136FGFR30.34761608
137MAPK140.33382676
138JAK20.31828154
139MAPK110.31116449
140TRPM70.30846774
141MAP2K30.29972282
142AKT10.27555913
143SGK20.27531614
144MUSK0.26638927
145CLK10.26015281
146TYK20.25887727
147KIT0.24941462
148CSNK1D0.24818395
149PRKD30.24083209
150NLK0.23316944
151ZAP700.20923792
152GSK3B0.18996815

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.33982923
2Fanconi anemia pathway_Homo sapiens_hsa034603.13214055
3RNA polymerase_Homo sapiens_hsa030203.02755501
4Homologous recombination_Homo sapiens_hsa034402.79983763
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63773626
6Basal transcription factors_Homo sapiens_hsa030222.57724559
7RNA transport_Homo sapiens_hsa030132.28687968
8p53 signaling pathway_Homo sapiens_hsa041152.25317788
9RNA degradation_Homo sapiens_hsa030182.21908894
10Vitamin B6 metabolism_Homo sapiens_hsa007502.02444982
11mRNA surveillance pathway_Homo sapiens_hsa030151.91359729
12Ribosome_Homo sapiens_hsa030101.78444486
13DNA replication_Homo sapiens_hsa030301.75499853
14Herpes simplex infection_Homo sapiens_hsa051681.73013912
15Spliceosome_Homo sapiens_hsa030401.69962630
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62161526
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.59462608
18Non-homologous end-joining_Homo sapiens_hsa034501.59145766
19Proteasome_Homo sapiens_hsa030501.58668761
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.51236756
21Allograft rejection_Homo sapiens_hsa053301.50655146
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50257789
23MicroRNAs in cancer_Homo sapiens_hsa052061.50185071
24Pancreatic cancer_Homo sapiens_hsa052121.41464275
25Autoimmune thyroid disease_Homo sapiens_hsa053201.37731272
26Primary immunodeficiency_Homo sapiens_hsa053401.34868696
27Sphingolipid metabolism_Homo sapiens_hsa006001.34086813
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30463091
29Lysine degradation_Homo sapiens_hsa003101.30283786
30Pyrimidine metabolism_Homo sapiens_hsa002401.26701400
31Base excision repair_Homo sapiens_hsa034101.25298705
32Nucleotide excision repair_Homo sapiens_hsa034201.24485308
33Mismatch repair_Homo sapiens_hsa034301.22788113
34Circadian rhythm_Homo sapiens_hsa047101.22101422
35Prolactin signaling pathway_Homo sapiens_hsa049171.20681029
36Hepatitis B_Homo sapiens_hsa051611.19551282
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18737691
38Measles_Homo sapiens_hsa051621.16101182
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14523623
40Graft-versus-host disease_Homo sapiens_hsa053321.13324436
41Influenza A_Homo sapiens_hsa051641.13047628
42Chronic myeloid leukemia_Homo sapiens_hsa052201.09801347
43Thyroid cancer_Homo sapiens_hsa052161.09048185
44Asthma_Homo sapiens_hsa053101.08580137
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06590279
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.05407721
47Small cell lung cancer_Homo sapiens_hsa052221.03999252
48Purine metabolism_Homo sapiens_hsa002301.03286692
49FoxO signaling pathway_Homo sapiens_hsa040681.02487897
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01977531
51TGF-beta signaling pathway_Homo sapiens_hsa043501.01258026
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01018676
53Hematopoietic cell lineage_Homo sapiens_hsa046401.00891911
54Epstein-Barr virus infection_Homo sapiens_hsa051691.00508142
55Non-small cell lung cancer_Homo sapiens_hsa052230.98395603
56Prostate cancer_Homo sapiens_hsa052150.97181216
57B cell receptor signaling pathway_Homo sapiens_hsa046620.96025510
58Leishmaniasis_Homo sapiens_hsa051400.95168653
59Viral carcinogenesis_Homo sapiens_hsa052030.92588195
60Legionellosis_Homo sapiens_hsa051340.87104291
61Oocyte meiosis_Homo sapiens_hsa041140.85959143
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85709960
63Endometrial cancer_Homo sapiens_hsa052130.84106219
64HTLV-I infection_Homo sapiens_hsa051660.83938601
65Acute myeloid leukemia_Homo sapiens_hsa052210.83122008
66Malaria_Homo sapiens_hsa051440.82870981
67Type I diabetes mellitus_Homo sapiens_hsa049400.81463416
68Renal cell carcinoma_Homo sapiens_hsa052110.79767303
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79292389
70Colorectal cancer_Homo sapiens_hsa052100.78879379
71mTOR signaling pathway_Homo sapiens_hsa041500.78023357
72Chemokine signaling pathway_Homo sapiens_hsa040620.74003715
73Choline metabolism in cancer_Homo sapiens_hsa052310.71837973
74Apoptosis_Homo sapiens_hsa042100.71812283
75TNF signaling pathway_Homo sapiens_hsa046680.67651417
76Antigen processing and presentation_Homo sapiens_hsa046120.67224850
77Toxoplasmosis_Homo sapiens_hsa051450.67021854
78T cell receptor signaling pathway_Homo sapiens_hsa046600.66497056
79Tuberculosis_Homo sapiens_hsa051520.66213744
80Osteoclast differentiation_Homo sapiens_hsa043800.65826467
81* Pentose phosphate pathway_Homo sapiens_hsa000300.65814424
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65578985
83Bladder cancer_Homo sapiens_hsa052190.64861975
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.63921259
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63250645
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61657395
87VEGF signaling pathway_Homo sapiens_hsa043700.61470778
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.61123716
89HIF-1 signaling pathway_Homo sapiens_hsa040660.60654289
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59534704
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59509027
92One carbon pool by folate_Homo sapiens_hsa006700.59202211
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59184283
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.58107664
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56553233
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53903495
97Viral myocarditis_Homo sapiens_hsa054160.52934401
98Shigellosis_Homo sapiens_hsa051310.52731093
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52642687
100Dorso-ventral axis formation_Homo sapiens_hsa043200.52308341
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52132371
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.52074825
103Inositol phosphate metabolism_Homo sapiens_hsa005620.51335144
104Other glycan degradation_Homo sapiens_hsa005110.50295549
105ErbB signaling pathway_Homo sapiens_hsa040120.50128663
106Hepatitis C_Homo sapiens_hsa051600.49280030
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48707156
108* Carbon metabolism_Homo sapiens_hsa012000.48673429
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48556068
110Pathways in cancer_Homo sapiens_hsa052000.47696984
111Fructose and mannose metabolism_Homo sapiens_hsa000510.47368091
112* Biosynthesis of amino acids_Homo sapiens_hsa012300.47184030
113Platelet activation_Homo sapiens_hsa046110.45836460
114Melanoma_Homo sapiens_hsa052180.43231840
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41793445
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41640574
117Notch signaling pathway_Homo sapiens_hsa043300.39004413
118MAPK signaling pathway_Homo sapiens_hsa040100.37374685
119Vitamin digestion and absorption_Homo sapiens_hsa049770.36522749
120Adherens junction_Homo sapiens_hsa045200.34854788
121Linoleic acid metabolism_Homo sapiens_hsa005910.34393206
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34305885
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34251231
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33947863
125Sulfur relay system_Homo sapiens_hsa041220.32236237
126Selenocompound metabolism_Homo sapiens_hsa004500.31384380
127Systemic lupus erythematosus_Homo sapiens_hsa053220.30330297

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