RPL10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* viral transcription (GO:0019083)9.63206118
2* translational termination (GO:0006415)9.29840434
3ribosomal small subunit assembly (GO:0000028)8.40393149
4ribosomal small subunit biogenesis (GO:0042274)8.38693530
5* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.22609157
6* cotranslational protein targeting to membrane (GO:0006613)8.08820517
7* protein targeting to ER (GO:0045047)8.07219507
8* translational elongation (GO:0006414)7.94464392
9* establishment of protein localization to endoplasmic reticulum (GO:0072599)7.72788116
10* protein localization to endoplasmic reticulum (GO:0070972)7.55130728
11* viral life cycle (GO:0019058)7.25571292
12* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.25550826
13* cellular protein complex disassembly (GO:0043624)7.20262811
14* translational initiation (GO:0006413)6.94946860
15maturation of SSU-rRNA (GO:0030490)6.82545100
16* protein complex disassembly (GO:0043241)6.26737167
17ribosomal large subunit biogenesis (GO:0042273)6.20717636
18* macromolecular complex disassembly (GO:0032984)5.85242452
19* protein targeting to membrane (GO:0006612)5.40148442
20* nuclear-transcribed mRNA catabolic process (GO:0000956)5.17725859
21* translation (GO:0006412)5.13270210
22* mRNA catabolic process (GO:0006402)4.90385551
23formation of translation preinitiation complex (GO:0001731)4.64666828
24ribonucleoprotein complex biogenesis (GO:0022613)4.64459750
25* RNA catabolic process (GO:0006401)4.56747644
26* establishment of protein localization to membrane (GO:0090150)3.68555307
27rRNA processing (GO:0006364)3.66731860
28rRNA metabolic process (GO:0016072)3.52493239
29cellular component biogenesis (GO:0044085)3.48124175
30DNA strand elongation involved in DNA replication (GO:0006271)3.47006693
31DNA unwinding involved in DNA replication (GO:0006268)3.40835322
32positive regulation of gamma-delta T cell activation (GO:0046645)3.38039150
33* establishment of protein localization to organelle (GO:0072594)3.34295049
34* protein targeting (GO:0006605)3.34142012
35folic acid-containing compound biosynthetic process (GO:0009396)3.33834718
36antigen processing and presentation of endogenous antigen (GO:0019883)3.32901470
37negative thymic T cell selection (GO:0045060)3.32380088
38positive thymic T cell selection (GO:0045059)3.32273637
39telomere maintenance via semi-conservative replication (GO:0032201)3.30962299
40negative T cell selection (GO:0043383)3.29157631
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28937270
42DNA strand elongation (GO:0022616)3.27370750
43establishment of integrated proviral latency (GO:0075713)3.27245558
44DNA deamination (GO:0045006)3.24412540
45thymic T cell selection (GO:0045061)3.17577854
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.11654105
47ATP synthesis coupled proton transport (GO:0015986)3.11654105
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.11639411
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.03646488
50negative regulation of RNA splicing (GO:0033119)2.99065499
51negative regulation of erythrocyte differentiation (GO:0045647)2.98904597
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93827452
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88572148
54telomere maintenance via recombination (GO:0000722)2.86806253
55DNA replication initiation (GO:0006270)2.86163453
56deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82471276
57UTP biosynthetic process (GO:0006228)2.81706613
58spliceosomal snRNP assembly (GO:0000387)2.80374474
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.78098744
60ribosome assembly (GO:0042255)2.75785950
61positive T cell selection (GO:0043368)2.74534498
62T cell selection (GO:0045058)2.73553271
63ncRNA 3-end processing (GO:0043628)2.72334296
64viral protein processing (GO:0019082)2.71693293
65regulation of protein heterodimerization activity (GO:0043497)2.71482102
66* protein localization to membrane (GO:0072657)2.71007337
67positive regulation of B cell differentiation (GO:0045579)2.69732598
68negative regulation of ligase activity (GO:0051352)2.68859890
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68859890
70mitotic recombination (GO:0006312)2.68695902
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.68150287
72establishment of viral latency (GO:0019043)2.67968438
73nucleobase biosynthetic process (GO:0046112)2.67889552
74pteridine-containing compound biosynthetic process (GO:0042559)2.67671706
75antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.66375554
76ribosome biogenesis (GO:0042254)2.65817275
77tolerance induction (GO:0002507)2.65635003
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.65453745
79negative regulation of cell killing (GO:0031342)2.65453745
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.64712675
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.63087826
82proteasome assembly (GO:0043248)2.63044677
83* gene expression (GO:0010467)2.62926928
84establishment of protein localization to mitochondrial membrane (GO:0090151)2.62545217
85GTP biosynthetic process (GO:0006183)2.62174329
86protein localization to kinetochore (GO:0034501)2.61863915
87* cellular component disassembly (GO:0022411)2.60972277
88positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.60721859
89signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.60710843
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.60710843
91leukocyte aggregation (GO:0070486)2.60513159
92spliceosomal complex assembly (GO:0000245)2.59905053
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.59253514
94myeloid cell homeostasis (GO:0002262)2.58975145
95nucleotide-excision repair, DNA gap filling (GO:0006297)2.57724183
96positive regulation of granulocyte differentiation (GO:0030854)2.57195330
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.55433148
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.55433148
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.55433148
100telomere maintenance via telomere lengthening (GO:0010833)2.55415025
101signal transduction involved in DNA damage checkpoint (GO:0072422)2.55052692
102signal transduction involved in DNA integrity checkpoint (GO:0072401)2.55052692
103pseudouridine synthesis (GO:0001522)2.54166746
104anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.53902862
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53539790
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.52097574
107pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.52003599
108UTP metabolic process (GO:0046051)2.51013368
109transcription elongation from RNA polymerase III promoter (GO:0006385)2.50291300
110termination of RNA polymerase III transcription (GO:0006386)2.50291300
111T cell apoptotic process (GO:0070231)2.50128453
112signal transduction involved in cell cycle checkpoint (GO:0072395)2.49903098
113* protein localization to organelle (GO:0033365)2.49244355
114modulation by virus of host process (GO:0019054)2.48220204
115cellular response to interleukin-4 (GO:0071353)2.47754543
116ncRNA processing (GO:0034470)2.47713409
117nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.45887495
118DNA replication-dependent nucleosome assembly (GO:0006335)2.43204547
119DNA replication-dependent nucleosome organization (GO:0034723)2.43204547
120regulation of gamma-delta T cell differentiation (GO:0045586)2.42943954
1213-UTR-mediated mRNA stabilization (GO:0070935)2.40947423
122ribonucleoprotein complex assembly (GO:0022618)2.40833844
123mitotic nuclear envelope disassembly (GO:0007077)2.39625134
124guanosine-containing compound biosynthetic process (GO:1901070)2.38380804
125Peyers patch development (GO:0048541)2.38187608
126mucosal-associated lymphoid tissue development (GO:0048537)2.38187608
127IMP biosynthetic process (GO:0006188)2.38167113
128regulation of cellular amino acid metabolic process (GO:0006521)2.37873958
129pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.37177649
130pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.36539046
131CTP biosynthetic process (GO:0006241)2.35930324
132CTP metabolic process (GO:0046036)2.35930324
133regulation of B cell receptor signaling pathway (GO:0050855)2.34447858
134pentose metabolic process (GO:0019321)2.32707481
135GDP-mannose metabolic process (GO:0019673)2.32420088
136negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.30598882
137oxidative phosphorylation (GO:0006119)2.29543791
138regulation of translational fidelity (GO:0006450)2.27986775
139virion assembly (GO:0019068)2.26246699
140response to interleukin-4 (GO:0070670)2.23648867
141NIK/NF-kappaB signaling (GO:0038061)2.22837800
142viral mRNA export from host cell nucleus (GO:0046784)2.22041393
143regulation of interleukin-2 biosynthetic process (GO:0045076)2.21156443
144regulation of B cell differentiation (GO:0045577)2.20613068
145regulation of gamma-delta T cell activation (GO:0046643)2.17771480
146pyrimidine nucleotide catabolic process (GO:0006244)2.17200943
147peptidyl-arginine omega-N-methylation (GO:0035247)2.16739338
148purine deoxyribonucleotide catabolic process (GO:0009155)2.16556941
149positive regulation by symbiont of host defense response (GO:0052509)2.16472338
150modulation by symbiont of host defense response (GO:0052031)2.16472338
151modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.16472338
152modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.16472338
153positive regulation by organism of defense response of other organism involved in symbiotic interact2.16472338
154modulation by symbiont of host immune response (GO:0052553)2.16472338
155negative regulation of phagocytosis (GO:0050765)2.15773202
156pentose-phosphate shunt (GO:0006098)2.13976038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.76568456
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.72768427
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04339330
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.73884969
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.36606833
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.29026638
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.25318149
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.98861261
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92642917
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81329878
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73771754
12* XRN2_22483619_ChIP-Seq_HELA_Human2.67984926
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62144388
14* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61897785
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60301800
16* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50737811
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47499549
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43089997
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.38312147
20* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34002504
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33320519
22* VDR_23849224_ChIP-Seq_CD4+_Human2.30050975
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21019865
24DCP1A_22483619_ChIP-Seq_HELA_Human2.18555719
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17445784
26* TTF2_22483619_ChIP-Seq_HELA_Human2.17092716
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08125240
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03945660
29* ELK1_19687146_ChIP-ChIP_HELA_Human2.01748256
30FOXP3_21729870_ChIP-Seq_TREG_Human2.01131551
31* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00729538
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97344030
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90659954
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.88768933
35GABP_19822575_ChIP-Seq_HepG2_Human1.73540634
36MAF_26560356_Chip-Seq_TH1_Human1.72872718
37MYC_22102868_ChIP-Seq_BL_Human1.70072318
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65447704
39UTX_26944678_Chip-Seq_JUKART_Human1.65263076
40MAF_26560356_Chip-Seq_TH2_Human1.62879313
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62735070
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60531158
43* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56988352
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52223848
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51312249
46* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50993328
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.50020704
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49646833
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48983103
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.48055869
51VDR_24763502_ChIP-Seq_THP-1_Human1.46876635
52CIITA_25753668_ChIP-Seq_RAJI_Human1.43948993
53LXR_22292898_ChIP-Seq_THP-1_Human1.43646430
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.42648452
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42487788
56* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41911873
57* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40852668
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40323794
59VDR_21846776_ChIP-Seq_THP-1_Human1.40149179
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39500548
61AR_21909140_ChIP-Seq_LNCAP_Human1.36465297
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.36413939
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36002327
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32331246
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.31754199
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30524748
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27977432
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26273954
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24598884
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24582202
71TCF7_22412390_ChIP-Seq_EML_Mouse1.24528042
72* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24460690
73SPI1_23547873_ChIP-Seq_NB4_Human1.24458993
74TFEB_21752829_ChIP-Seq_HELA_Human1.24233488
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24172859
76TP63_17297297_ChIP-ChIP_HaCaT_Human1.23900051
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23361374
78BP1_19119308_ChIP-ChIP_Hs578T_Human1.22729548
79KDM5A_27292631_Chip-Seq_BREAST_Human1.22595954
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.21974910
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20987078
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.20319896
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.18687785
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17793257
85* MYB_26560356_Chip-Seq_TH2_Human1.17510656
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17243537
87MYB_26560356_Chip-Seq_TH1_Human1.16995561
88KDM2B_26808549_Chip-Seq_DND41_Human1.16832478
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.16448001
90NCOR1_26117541_ChIP-Seq_K562_Human1.16337477
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16203231
92* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13892427
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13825948
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13545433
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.13276086
96P68_20966046_ChIP-Seq_HELA_Human1.12374072
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12234847
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.12226571
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10291706
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10092191
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.09499688
102RACK7_27058665_Chip-Seq_MCF-7_Human1.08807169
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07718600
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07202488
105BCL6_27268052_Chip-Seq_Bcells_Human1.07075021
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06844619
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04811948
108* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04722791
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04399646
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04355221
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04067882
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03899211
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03519754
114IRF8_22096565_ChIP-ChIP_GC-B_Human1.01951323
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00808467
116BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99530014
117PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99252027
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97908320
119MYC_18940864_ChIP-ChIP_HL60_Human0.97159412
120TP63_19390658_ChIP-ChIP_HaCaT_Human0.97098791
121HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96741761
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96658786
123MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96522824
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92911830
125MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91515651
126OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90758102
127SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90217623
128E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90080435
129MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88792858
130RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88650868
131KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87182608
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87182608
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87182608
134TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86138101
135SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85930930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.41532297
2MP0009379_abnormal_foot_pigmentation4.27287451
3MP0004957_abnormal_blastocyst_morpholog3.46061339
4MP0003077_abnormal_cell_cycle2.68197863
5MP0010094_abnormal_chromosome_stability2.43058922
6MP0010352_gastrointestinal_tract_polyps2.39205073
7MP0008057_abnormal_DNA_replication2.29904321
8MP0003111_abnormal_nucleus_morphology2.28544798
9MP0002396_abnormal_hematopoietic_system2.25602238
10MP0000490_abnormal_crypts_of1.99362497
11MP0008932_abnormal_embryonic_tissue1.96451655
12MP0009333_abnormal_splenocyte_physiolog1.88530768
13MP0008007_abnormal_cellular_replicative1.85406142
14MP0009278_abnormal_bone_marrow1.73552885
15MP0004808_abnormal_hematopoietic_stem1.70084696
16MP0006054_spinal_hemorrhage1.66609275
17MP0003763_abnormal_thymus_physiology1.64217294
18MP0008058_abnormal_DNA_repair1.63638748
19MP0001730_embryonic_growth_arrest1.60777186
20MP0002166_altered_tumor_susceptibility1.60390978
21MP0008995_early_reproductive_senescence1.59284215
22MP0000350_abnormal_cell_proliferation1.57462262
23MP0003123_paternal_imprinting1.53678255
24MP0002009_preneoplasia1.50783478
25MP0003806_abnormal_nucleotide_metabolis1.46313652
26MP0001835_abnormal_antigen_presentation1.43348373
27MP0000858_altered_metastatic_potential1.42247506
28MP0000685_abnormal_immune_system1.41989712
29MP0008260_abnormal_autophagy1.40890764
30MP0003567_abnormal_fetal_cardiomyocyte1.38662680
31MP0002419_abnormal_innate_immunity1.37603760
32MP0002398_abnormal_bone_marrow1.33437425
33MP0002938_white_spotting1.29988461
34MP0002019_abnormal_tumor_incidence1.29759046
35MP0000678_abnormal_parathyroid_gland1.29657192
36MP0002722_abnormal_immune_system1.28417912
37MP0002277_abnormal_respiratory_mucosa1.28274575
38MP0001800_abnormal_humoral_immune1.27308339
39MP0003786_premature_aging1.24375023
40MP0005220_abnormal_exocrine_pancreas1.24366552
41MP0002006_tumorigenesis1.23959672
42MP0005451_abnormal_body_composition1.23153237
43MP0004381_abnormal_hair_follicle1.22503124
44MP0001697_abnormal_embryo_size1.22472921
45MP0000703_abnormal_thymus_morphology1.21608707
46MP0000689_abnormal_spleen_morphology1.20406690
47MP0004185_abnormal_adipocyte_glucose1.20083511
48MP0003436_decreased_susceptibility_to1.17922983
49MP0005174_abnormal_tail_pigmentation1.17513017
50MP0002080_prenatal_lethality1.15416592
51MP0000313_abnormal_cell_death1.14666856
52MP0003186_abnormal_redox_activity1.13775353
53MP0002163_abnormal_gland_morphology1.12667746
54MP0002429_abnormal_blood_cell1.11404697
55MP0002452_abnormal_antigen_presenting1.11055372
56MP0002405_respiratory_system_inflammati1.10623626
57MP0001545_abnormal_hematopoietic_system1.09827826
58MP0005397_hematopoietic_system_phenotyp1.09827826
59MP0005671_abnormal_response_to1.09447714
60MP0002420_abnormal_adaptive_immunity1.09385770
61MP0001853_heart_inflammation1.08513014
62MP0009785_altered_susceptibility_to1.07519891
63MP0000716_abnormal_immune_system1.07233184
64MP0002796_impaired_skin_barrier1.07114618
65MP0005000_abnormal_immune_tolerance1.07112952
66MP0001819_abnormal_immune_cell1.07047931
67MP0003191_abnormal_cellular_cholesterol1.05541890
68MP0000358_abnormal_cell_content/1.05142681
69MP0003303_peritoneal_inflammation1.04956250
70MP0003866_abnormal_defecation1.04505506
71MP0002723_abnormal_immune_serum1.03978395
72MP0005025_abnormal_response_to1.03757289
73MP0002933_joint_inflammation1.02353231
74MP0001873_stomach_inflammation1.01677777
75MP0005023_abnormal_wound_healing1.01035541
76MP0010307_abnormal_tumor_latency1.00295164
77MP0001672_abnormal_embryogenesis/_devel1.00073557
78MP0005380_embryogenesis_phenotype1.00073557
79MP0004197_abnormal_fetal_growth/weight/0.97577500
80MP0002086_abnormal_extraembryonic_tissu0.96899781
81MP0010155_abnormal_intestine_physiology0.96684087
82MP0000465_gastrointestinal_hemorrhage0.95709507
83MP0006036_abnormal_mitochondrial_physio0.94467911
84MP0003300_gastrointestinal_ulcer0.93441105
85MP0002088_abnormal_embryonic_growth/wei0.92855424
86MP0002084_abnormal_developmental_patter0.92824521
87MP0002085_abnormal_embryonic_tissue0.92679594
88MP0002249_abnormal_larynx_morphology0.92413189
89MP0003984_embryonic_growth_retardation0.91659506
90MP0010030_abnormal_orbit_morphology0.90961366
91MP0002132_abnormal_respiratory_system0.90736957
92MP0005083_abnormal_biliary_tract0.90512471
93MP0002148_abnormal_hypersensitivity_rea0.89367583
94MP0005408_hypopigmentation0.87962050
95MP0003315_abnormal_perineum_morphology0.84863435
96MP0001663_abnormal_digestive_system0.84487924
97MP0005076_abnormal_cell_differentiation0.84205947
98MP0002095_abnormal_skin_pigmentation0.82095827
99MP0001790_abnormal_immune_system0.81888604
100MP0005387_immune_system_phenotype0.81888604
101MP0003941_abnormal_skin_development0.81262589
102MP0000477_abnormal_intestine_morphology0.80855443
103MP0003566_abnormal_cell_adhesion0.80012571
104MP0001533_abnormal_skeleton_physiology0.79867471
105MP0001845_abnormal_inflammatory_respons0.78584766
106MP0008469_abnormal_protein_level0.78482012
107MP0003724_increased_susceptibility_to0.78479343
108MP0000613_abnormal_salivary_gland0.77889486
109MP0002877_abnormal_melanocyte_morpholog0.77550349
110MP0001346_abnormal_lacrimal_gland0.77347399
111MP0000537_abnormal_urethra_morphology0.76247261
112MP0009931_abnormal_skin_appearance0.76166931
113MP0005501_abnormal_skin_physiology0.75842529
114MP0001851_eye_inflammation0.75137076
115MP0005058_abnormal_lysosome_morphology0.73888916
116MP0005379_endocrine/exocrine_gland_phen0.73061141
117MP0000372_irregular_coat_pigmentation0.73013399
118MP0005464_abnormal_platelet_physiology0.72609768
119MP0005381_digestive/alimentary_phenotyp0.72524095
120MP0004264_abnormal_extraembryonic_tissu0.72202312
121MP0005075_abnormal_melanosome_morpholog0.72137124
122MP0004947_skin_inflammation0.71549603
123MP0001293_anophthalmia0.71283315
124MP0000750_abnormal_muscle_regeneration0.70040291
125MP0000681_abnormal_thyroid_gland0.69586547
126MP0003448_altered_tumor_morphology0.69334383
127MP0008438_abnormal_cutaneous_collagen0.67938723
128MP0006035_abnormal_mitochondrial_morpho0.66953583
129MP0009053_abnormal_anal_canal0.66403128
130MP0001881_abnormal_mammary_gland0.65162392
131MP0001348_abnormal_lacrimal_gland0.65106018
132MP0005390_skeleton_phenotype0.64141471

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.08272406
2Reticulocytopenia (HP:0001896)7.75487175
3Abnormal number of erythroid precursors (HP:0012131)7.70088185
4Macrocytic anemia (HP:0001972)6.07450804
5Pallor (HP:0000980)5.87919940
6Panhypogammaglobulinemia (HP:0003139)4.19408289
7Abnormal hemoglobin (HP:0011902)4.04641964
8Aplastic anemia (HP:0001915)4.04117496
9Agammaglobulinemia (HP:0004432)3.79999700
10Thrombocytosis (HP:0001894)3.53364934
11Colon cancer (HP:0003003)3.44576795
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.31254098
13Multiple enchondromatosis (HP:0005701)3.21280018
14Seborrheic dermatitis (HP:0001051)3.11657937
15Hypertensive crisis (HP:0100735)3.07290725
16Recurrent viral infections (HP:0004429)3.03394549
17Obstructive lung disease (HP:0006536)2.97850715
18Chronic obstructive pulmonary disease (HP:0006510)2.97850715
19Aplasia/Hypoplasia of the sacrum (HP:0008517)2.95315890
2011 pairs of ribs (HP:0000878)2.91241483
21Eczematoid dermatitis (HP:0000976)2.88917620
22Trismus (HP:0000211)2.84176071
23Stenosis of the external auditory canal (HP:0000402)2.83171102
24Colitis (HP:0002583)2.79073386
25Increased IgE level (HP:0003212)2.78057833
26Recurrent abscess formation (HP:0002722)2.70107162
27Absent thumb (HP:0009777)2.69344612
28IgM deficiency (HP:0002850)2.68868583
29Meningitis (HP:0001287)2.68123728
30Increased intramyocellular lipid droplets (HP:0012240)2.67888906
31Recurrent bacterial skin infections (HP:0005406)2.66780033
32Abnormality of reticulocytes (HP:0004312)2.63997031
33Recurrent fungal infections (HP:0002841)2.62030286
34Gastrointestinal inflammation (HP:0004386)2.61398622
35Oral leukoplakia (HP:0002745)2.57688706
36Depressed nasal ridge (HP:0000457)2.53461202
37Increased muscle lipid content (HP:0009058)2.52935254
38Papilloma (HP:0012740)2.51653097
39Verrucae (HP:0200043)2.51653097
40Glossoptosis (HP:0000162)2.49705535
41Selective tooth agenesis (HP:0001592)2.44987670
42Carpal bone hypoplasia (HP:0001498)2.41906091
43Chronic mucocutaneous candidiasis (HP:0002728)2.37440303
44Recurrent cutaneous fungal infections (HP:0011370)2.37440303
45Inflammation of the large intestine (HP:0002037)2.36084346
46Increased IgM level (HP:0003496)2.34755956
47Cellulitis (HP:0100658)2.34342445
48Granulocytopenia (HP:0001913)2.31782160
49Congenital, generalized hypertrichosis (HP:0004540)2.30143642
50Pustule (HP:0200039)2.27797418
51Increased hepatocellular lipid droplets (HP:0006565)2.27586141
52Rough bone trabeculation (HP:0100670)2.26161982
53Thick lower lip vermilion (HP:0000179)2.25969802
54Abnormality of small intestinal villus morphology (HP:0011472)2.25421853
55Villous atrophy (HP:0011473)2.25421853
56Microretrognathia (HP:0000308)2.24837007
57Severe combined immunodeficiency (HP:0004430)2.21498151
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21467374
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21467374
60Type I transferrin isoform profile (HP:0003642)2.21454748
61Lymphopenia (HP:0001888)2.19612728
62Exertional dyspnea (HP:0002875)2.16713223
63Encephalitis (HP:0002383)2.13606939
64Myositis (HP:0100614)2.12884549
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.11573250
66Viral hepatitis (HP:0006562)2.11177021
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08694897
68Mitochondrial inheritance (HP:0001427)2.06624066
69Gastrointestinal stroma tumor (HP:0100723)2.06019549
70Migraine (HP:0002076)2.04722200
71Abnormality of the parietal bone (HP:0002696)2.04541919
72Gastrointestinal infarctions (HP:0005244)2.04115965
73Acute necrotizing encephalopathy (HP:0006965)2.03688120
74Recurrent skin infections (HP:0001581)2.03359340
75Mediastinal lymphadenopathy (HP:0100721)2.03040384
76Missing ribs (HP:0000921)2.02699286
77Ragged-red muscle fibers (HP:0003200)2.02691166
78Truncus arteriosus (HP:0001660)2.01040822
79Hypoplasia of the radius (HP:0002984)1.99348238
80Spinal cord lesions (HP:0100561)1.98802497
81Syringomyelia (HP:0003396)1.98802497
82Lipid accumulation in hepatocytes (HP:0006561)1.98350063
83Myelodysplasia (HP:0002863)1.97873100
84Breast hypoplasia (HP:0003187)1.96932408
85Broad distal phalanx of finger (HP:0009836)1.96638735
86Elevated erythrocyte sedimentation rate (HP:0003565)1.93358763
87Premature skin wrinkling (HP:0100678)1.93344647
88Bicuspid aortic valve (HP:0001647)1.90941178
89Basal cell carcinoma (HP:0002671)1.90327885
90Atresia of the external auditory canal (HP:0000413)1.89368118
91Triphalangeal thumb (HP:0001199)1.88422905
92Neoplasm of the pancreas (HP:0002894)1.87832354
93Fatigue (HP:0012378)1.87007312
94Petechiae (HP:0000967)1.86609042
95Muscle fiber atrophy (HP:0100295)1.85546480
96Recurrent bronchitis (HP:0002837)1.80799401
97Neutropenia (HP:0001875)1.80617122
98Skin rash (HP:0000988)1.79946755
99Birth length less than 3rd percentile (HP:0003561)1.79200008
100Myopathic facies (HP:0002058)1.78998423
101Lymphoma (HP:0002665)1.78771222
102Mesangial abnormality (HP:0001966)1.77961842
103Vacuolated lymphocytes (HP:0001922)1.77698808
104Autoimmune hemolytic anemia (HP:0001890)1.77452606
105Abnormal number of incisors (HP:0011064)1.76312200
106Hepatocellular necrosis (HP:0001404)1.75547218
107Increased CSF lactate (HP:0002490)1.75445933
108Combined immunodeficiency (HP:0005387)1.75387465
109Hypergammaglobulinemia (HP:0010702)1.72313954
110Orthostatic hypotension (HP:0001278)1.72185042
111Abnormal mitochondria in muscle tissue (HP:0008316)1.71773269
112Vasculitis (HP:0002633)1.71694249
113Polygenic inheritance (HP:0010982)1.71653635
114IgG deficiency (HP:0004315)1.71015420
115Aplasia/Hypoplasia of the thymus (HP:0010515)1.71014561
116Exercise intolerance (HP:0003546)1.70565555
117Asplenia (HP:0001746)1.70318200
118Hypoproteinemia (HP:0003075)1.70078312
119Stomatitis (HP:0010280)1.69605731
120Degeneration of anterior horn cells (HP:0002398)1.69294269
121Abnormality of the anterior horn cell (HP:0006802)1.69294269
122Agnosia (HP:0010524)1.68988701
123Abnormal trabecular bone morphology (HP:0100671)1.68938849
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.68581151
125Proximal placement of thumb (HP:0009623)1.67917174
126Thoracolumbar scoliosis (HP:0002944)1.67667339
127Poikiloderma (HP:0001029)1.67037899
128Abnormality of T cell physiology (HP:0011840)1.66717529
129Microvesicular hepatic steatosis (HP:0001414)1.64897136
130Respiratory difficulties (HP:0002880)1.64575857
131Amaurosis fugax (HP:0100576)1.63427556
132Abnormal protein glycosylation (HP:0012346)1.63299584
133Abnormal glycosylation (HP:0012345)1.63299584
134Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.63299584
135Abnormal protein N-linked glycosylation (HP:0012347)1.63299584
136Poor head control (HP:0002421)1.63072434
137Pancytopenia (HP:0001876)1.63026092
138Woolly hair (HP:0002224)1.61728243
139Deviation of the thumb (HP:0009603)1.61685890
140Progressive muscle weakness (HP:0003323)1.60149203
141Cleft eyelid (HP:0000625)1.59236531
1423-Methylglutaconic aciduria (HP:0003535)1.57657382
143Increased density of long bones (HP:0006392)1.57653586
144Sparse lateral eyebrow (HP:0005338)1.57438885
145Reduced antithrombin III activity (HP:0001976)1.56737032
146Premature graying of hair (HP:0002216)1.56047686
147Squamous cell carcinoma (HP:0002860)1.55993049
148Abnormality of the preputium (HP:0100587)1.55540881
149Broad face (HP:0000283)1.54950177
150Abnormality of T cells (HP:0002843)1.53923368
151Patellar aplasia (HP:0006443)1.53144465
152Vertebral hypoplasia (HP:0008417)1.52250163
153Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.52250163
154Rectal prolapse (HP:0002035)1.52218582
155Aplasia/Hypoplasia of the spleen (HP:0010451)1.51555193
156Renal Fanconi syndrome (HP:0001994)1.50440670
157Hepatic necrosis (HP:0002605)1.50140727
158Progressive macrocephaly (HP:0004481)1.48571983
159Bone marrow hypocellularity (HP:0005528)1.45927511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.65075764
2VRK23.87244047
3SMG13.31700333
4PRPF4B3.04249231
5BUB13.03007073
6TRIB32.87913945
7RPS6KB22.86503262
8WEE12.85917081
9EEF2K2.68351198
10PASK2.48138046
11PIM22.40955320
12LRRK22.36998746
13TGFBR12.31802555
14EIF2AK32.28176423
15EIF2AK12.12625004
16CDC72.04619687
17STK161.82152361
18FLT31.80671402
19MAP4K11.80589750
20VRK11.70637552
21IRAK41.70151150
22BRSK21.69421461
23CDK191.62297749
24MST41.59012744
25RPS6KA41.53673261
26MAPKAPK31.49840420
27TSSK61.49453634
28TESK21.43189334
29TLK11.40143908
30DYRK31.38186371
31SRPK11.36666371
32STK101.36103108
33ACVR1B1.26949511
34AURKB1.26922092
35RIPK41.24644650
36TAF11.24564241
37NEK21.23412070
38CDK71.22524376
39ZAP701.19327195
40SCYL21.16428493
41PKN21.15781496
42FES1.12953208
43SIK11.12329883
44KDR1.12032170
45TXK1.10850924
46EPHA21.09486035
47ILK1.08533492
48PAK41.07660381
49MKNK11.07213509
50MAP3K101.05146714
51BTK1.01912320
52ERN11.01403501
53TEC0.99673169
54MAP3K80.99243293
55MAP2K30.96892565
56IKBKE0.96288760
57PIM10.93530347
58TESK10.92549309
59KIT0.91672096
60PLK10.86081719
61GRK60.85340615
62PAK20.84320892
63NLK0.83322234
64NME10.81506843
65TAOK20.80952665
66ATR0.80264986
67LIMK10.80192201
68HCK0.79014021
69CDK40.78207360
70AURKA0.78037736
71MAP3K130.75777130
72ICK0.75401432
73CDK60.74059216
74CSNK2A20.73468137
75RPS6KA50.70950564
76TYK20.70117636
77PAK10.67441391
78CSF1R0.66775101
79IRAK20.65616256
80IKBKB0.65098363
81MARK30.63932024
82PTK60.63446288
83MAPK110.63344857
84MAP2K20.63311652
85TAOK30.62526770
86CLK10.61631381
87JAK30.61535544
88MAP3K30.61131798
89CSK0.61085635
90FGFR40.60991784
91PIK3CG0.59438784
92CSNK2A10.58486270
93CDK80.58308441
94TTK0.56456964
95CHEK10.55386393
96SIK30.55227546
97IRAK30.54962743
98BLK0.54415548
99MAP3K140.53839931
100MELK0.53707342
101SYK0.52719684
102TBK10.51523049
103TNK20.51480442
104DYRK1B0.50725391
105HIPK20.50304716
106ITK0.49889102
107CHEK20.49739788
108PLK30.49426831
109PLK40.48995979
110LCK0.48962169
111BRSK10.48317460
112CDK90.47450136
113PRKD20.46849201
114MAP3K10.45591570
115MAPKAPK50.45510564
116TGFBR20.44687780
117MAP3K110.44597076
118MAPK120.43359861
119LYN0.43139083
120CDK120.42905459
121EIF2AK20.42238205
122MAPKAPK20.39673886
123PRKCI0.39510913
124DAPK30.39401966
125BCKDK0.39293610
126MATK0.38236020
127GRK50.36761300
128BMPR1B0.35530467
129ABL20.35264987
130ARAF0.35072847
131STK40.34549908
132RPS6KA60.34334948
133RPS6KL10.34230010
134RPS6KC10.34230010

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030107.59653129
2DNA replication_Homo sapiens_hsa030303.59972072
3Proteasome_Homo sapiens_hsa030503.39326541
4Mismatch repair_Homo sapiens_hsa034303.02666724
5RNA polymerase_Homo sapiens_hsa030202.90275872
6Spliceosome_Homo sapiens_hsa030402.78881277
7Protein export_Homo sapiens_hsa030602.73619522
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.45082349
9RNA transport_Homo sapiens_hsa030132.22595089
10Nucleotide excision repair_Homo sapiens_hsa034202.19223484
11Pyrimidine metabolism_Homo sapiens_hsa002402.17905052
12Base excision repair_Homo sapiens_hsa034102.00610567
13Homologous recombination_Homo sapiens_hsa034401.99315864
14One carbon pool by folate_Homo sapiens_hsa006701.95106814
15Autoimmune thyroid disease_Homo sapiens_hsa053201.86722958
16Parkinsons disease_Homo sapiens_hsa050121.80475636
17Oxidative phosphorylation_Homo sapiens_hsa001901.80458222
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78909438
19Cell cycle_Homo sapiens_hsa041101.51744334
20Non-homologous end-joining_Homo sapiens_hsa034501.47274013
21RNA degradation_Homo sapiens_hsa030181.30879350
22Huntingtons disease_Homo sapiens_hsa050161.30409096
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26442066
24p53 signaling pathway_Homo sapiens_hsa041151.24730458
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19975207
26Antigen processing and presentation_Homo sapiens_hsa046121.17731576
27Folate biosynthesis_Homo sapiens_hsa007901.16601974
28Fanconi anemia pathway_Homo sapiens_hsa034601.11715157
29Non-small cell lung cancer_Homo sapiens_hsa052231.10133991
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08041013
31Alzheimers disease_Homo sapiens_hsa050101.06354077
32Epstein-Barr virus infection_Homo sapiens_hsa051691.04738697
33Basal transcription factors_Homo sapiens_hsa030221.03281850
34Sulfur relay system_Homo sapiens_hsa041220.97301755
35Primary immunodeficiency_Homo sapiens_hsa053400.94895717
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92226605
37Pancreatic cancer_Homo sapiens_hsa052120.91757351
38Type I diabetes mellitus_Homo sapiens_hsa049400.90736588
39Systemic lupus erythematosus_Homo sapiens_hsa053220.89385272
40Purine metabolism_Homo sapiens_hsa002300.86763599
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86701442
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86664134
43N-Glycan biosynthesis_Homo sapiens_hsa005100.83311534
44Legionellosis_Homo sapiens_hsa051340.79299968
45Herpes simplex infection_Homo sapiens_hsa051680.79150927
46Thyroid cancer_Homo sapiens_hsa052160.78065765
47Osteoclast differentiation_Homo sapiens_hsa043800.76654326
48mRNA surveillance pathway_Homo sapiens_hsa030150.76608665
49Viral carcinogenesis_Homo sapiens_hsa052030.74970336
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.73097415
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70008320
52Glutathione metabolism_Homo sapiens_hsa004800.68063189
53Hematopoietic cell lineage_Homo sapiens_hsa046400.67219060
54Fructose and mannose metabolism_Homo sapiens_hsa000510.66049918
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.61275201
56VEGF signaling pathway_Homo sapiens_hsa043700.60294829
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.58995818
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58474062
59Pentose phosphate pathway_Homo sapiens_hsa000300.58260108
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58058913
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.57348802
62Measles_Homo sapiens_hsa051620.56296048
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56234465
64Apoptosis_Homo sapiens_hsa042100.55963590
65HTLV-I infection_Homo sapiens_hsa051660.55911434
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.55073287
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51444152
68Other glycan degradation_Homo sapiens_hsa005110.51398018
69Small cell lung cancer_Homo sapiens_hsa052220.50251789
70Selenocompound metabolism_Homo sapiens_hsa004500.49259179
71Asthma_Homo sapiens_hsa053100.48918169
72Carbon metabolism_Homo sapiens_hsa012000.46498012
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46284835
74Acute myeloid leukemia_Homo sapiens_hsa052210.46074699
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45969510
76Leishmaniasis_Homo sapiens_hsa051400.45882269
77Allograft rejection_Homo sapiens_hsa053300.45384058
78Tuberculosis_Homo sapiens_hsa051520.45146044
79Bladder cancer_Homo sapiens_hsa052190.45084007
80Renal cell carcinoma_Homo sapiens_hsa052110.44809173
81Shigellosis_Homo sapiens_hsa051310.43742853
82Chronic myeloid leukemia_Homo sapiens_hsa052200.42337966
83Hepatitis B_Homo sapiens_hsa051610.41904314
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.40217862
85Hepatitis C_Homo sapiens_hsa051600.38841574
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38230829
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37032862
88Staphylococcus aureus infection_Homo sapiens_hsa051500.36242531
89Endometrial cancer_Homo sapiens_hsa052130.35402013
90Renin-angiotensin system_Homo sapiens_hsa046140.35150293
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34252234
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33158423
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32814144
94TGF-beta signaling pathway_Homo sapiens_hsa043500.32247266
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.32209817
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.31811416
97MicroRNAs in cancer_Homo sapiens_hsa052060.31229601
98Chemokine signaling pathway_Homo sapiens_hsa040620.30679024
99TNF signaling pathway_Homo sapiens_hsa046680.28549433
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27750629
101Metabolic pathways_Homo sapiens_hsa011000.27506936
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.27131842
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27118273
104Colorectal cancer_Homo sapiens_hsa052100.26739990
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26613945
106B cell receptor signaling pathway_Homo sapiens_hsa046620.26483661
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25163123
108Toxoplasmosis_Homo sapiens_hsa051450.24351937
109Arachidonic acid metabolism_Homo sapiens_hsa005900.24341944
110Alcoholism_Homo sapiens_hsa050340.24240531
111Pertussis_Homo sapiens_hsa051330.24064582
112Pathways in cancer_Homo sapiens_hsa052000.22352987
113Graft-versus-host disease_Homo sapiens_hsa053320.22133992
114Biosynthesis of amino acids_Homo sapiens_hsa012300.21500025
115Influenza A_Homo sapiens_hsa051640.21449442
116Prostate cancer_Homo sapiens_hsa052150.21402264
117Viral myocarditis_Homo sapiens_hsa054160.20765415
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.19118170
119HIF-1 signaling pathway_Homo sapiens_hsa040660.18581995
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17414535
121Notch signaling pathway_Homo sapiens_hsa043300.16896150
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16431348
123Galactose metabolism_Homo sapiens_hsa000520.16206587
124T cell receptor signaling pathway_Homo sapiens_hsa046600.14942487

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