ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.00833635
2	viral transcription (GO:0019083)	5.45332555
3	translational termination (GO:0006415)	5.27782334
4	DNA deamination (GO:0045006)	5.12785748
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.70353735
6	ATP synthesis coupled proton transport (GO:0015986)	4.70353735
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.66873941
8	maturation of SSU-rRNA (GO:0030490)	4.66210455
9	translational elongation (GO:0006414)	4.64949994
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.47105135
11	behavioral response to nicotine (GO:0035095)	4.46783888
12	cotranslational protein targeting to membrane (GO:0006613)	4.40497685
13	protein targeting to ER (GO:0045047)	4.37956469
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.23704479
15	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.23704479
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.18729770
17	protein localization to endoplasmic reticulum (GO:0070972)	4.15545278
18	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.05708138
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.02060698
20	viral life cycle (GO:0019058)	4.00676498
21	ribosomal small subunit biogenesis (GO:0042274)	3.99819980
22	cellular protein complex disassembly (GO:0043624)	3.93338318
23	water-soluble vitamin biosynthetic process (GO:0042364)	3.87045316
24	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.66062159
25	kynurenine metabolic process (GO:0070189)	3.59894147
26	protein complex biogenesis (GO:0070271)	3.57025200
27	cytidine catabolic process (GO:0006216)	3.56295885
28	cytidine deamination (GO:0009972)	3.56295885
29	cytidine metabolic process (GO:0046087)	3.56295885
30	sequestering of actin monomers (GO:0042989)	3.53907379
31	respiratory electron transport chain (GO:0022904)	3.53544816
32	electron transport chain (GO:0022900)	3.52886170
33	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.45210497
34	indole-containing compound catabolic process (GO:0042436)	3.44977400
35	indolalkylamine catabolic process (GO:0046218)	3.44977400
36	tryptophan catabolic process (GO:0006569)	3.44977400
37	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.35664488
38	rRNA catabolic process (GO:0016075)	3.35321212
39	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.33063709
40	translational initiation (GO:0006413)	3.28596517
41	protein complex disassembly (GO:0043241)	3.24856298
42	indolalkylamine metabolic process (GO:0006586)	3.23665743
43	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.20805466
44	protein neddylation (GO:0045116)	3.13014582
45	mitochondrial respiratory chain complex assembly (GO:0033108)	3.12911882
46	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.12266547
47	macromolecular complex disassembly (GO:0032984)	3.08907514
48	substrate-independent telencephalic tangential migration (GO:0021826)	3.04452411
49	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.04452411
50	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.01403175
51	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.01403175
52	NADH dehydrogenase complex assembly (GO:0010257)	3.01403175
53	translation (GO:0006412)	2.97580681
54	tryptophan metabolic process (GO:0006568)	2.96073073
55	mannosylation (GO:0097502)	2.94809156
56	protein-cofactor linkage (GO:0018065)	2.94570274
57	ribosomal large subunit biogenesis (GO:0042273)	2.92395073
58	cellular component biogenesis (GO:0044085)	2.90207321
59	chaperone-mediated protein transport (GO:0072321)	2.85428800
60	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.84140531
61	response to pheromone (GO:0019236)	2.83062620
62	ribonucleoprotein complex biogenesis (GO:0022613)	2.76441133
63	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.75202326
64	platelet dense granule organization (GO:0060155)	2.74995423
65	axoneme assembly (GO:0035082)	2.74665935
66	protein targeting to membrane (GO:0006612)	2.73606436
67	ubiquinone biosynthetic process (GO:0006744)	2.72866113
68	cytochrome complex assembly (GO:0017004)	2.72416781
69	tongue development (GO:0043586)	2.69673169
70	mRNA catabolic process (GO:0006402)	2.69106005
71	regulation of cilium movement (GO:0003352)	2.68748356
72	nonmotile primary cilium assembly (GO:0035058)	2.62369466
73	hydrogen ion transmembrane transport (GO:1902600)	2.61583024
74	ATP biosynthetic process (GO:0006754)	2.59046817
75	cell proliferation in forebrain (GO:0021846)	2.57166061
76	kidney morphogenesis (GO:0060993)	2.54235492
77	proton transport (GO:0015992)	2.53527143
78	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.52330864
79	respiratory chain complex IV assembly (GO:0008535)	2.51598639
80	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.50843384
81	hydrogen transport (GO:0006818)	2.48276005
82	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.48229583
83	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.47135029
84	adenosine metabolic process (GO:0046085)	2.46763140
85	RNA catabolic process (GO:0006401)	2.42611079
86	rRNA metabolic process (GO:0016072)	2.40150648
87	protein polyglutamylation (GO:0018095)	2.38662462
88	aldehyde catabolic process (GO:0046185)	2.38321222
89	rhodopsin mediated signaling pathway (GO:0016056)	2.37565000
90	negative regulation of T cell apoptotic process (GO:0070233)	2.36540806
91	piRNA metabolic process (GO:0034587)	2.36362723
92	replication fork processing (GO:0031297)	2.36165500
93	rRNA processing (GO:0006364)	2.35317825
94	pyrimidine nucleotide catabolic process (GO:0006244)	2.35291235
95	positive regulation of prostaglandin secretion (GO:0032308)	2.35274472
96	response to interferon-beta (GO:0035456)	2.34126789
97	axonemal dynein complex assembly (GO:0070286)	2.33086176
98	sulfation (GO:0051923)	2.32372616
99	tRNA processing (GO:0008033)	2.32043957
100	ubiquinone metabolic process (GO:0006743)	2.31882482

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.57805269
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.79247319
3	VDR_22108803_ChIP-Seq_LS180_Human	3.73798455
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.07843627
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.94796490
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.70102932
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.67552285
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.66817511
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.43900665
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.43630940
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.43499835
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.17389278
13	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.09873826
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.02435499
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.95241314
16	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.88220208
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.87891418
18	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.85258564
19	VDR_23849224_ChIP-Seq_CD4+_Human	1.81079962
20	FUS_26573619_Chip-Seq_HEK293_Human	1.77147545
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69159941
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66142984
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.65537821
24	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.64844269
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62178468
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.55435207
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.54917334
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.53651463
29	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.52258703
30	NANOG_20526341_ChIP-Seq_ESCs_Human	1.45078487
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.41935654
32	TAF2_19829295_ChIP-Seq_ESCs_Human	1.41342081
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.40840908
34	EWS_26573619_Chip-Seq_HEK293_Human	1.40022718
35	IGF1R_20145208_ChIP-Seq_DFB_Human	1.39011779
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.37572537
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.35874036
38	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34109435
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.32722741
40	AR_20517297_ChIP-Seq_VCAP_Human	1.31983831
41	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.30444721
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29642638
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.29642638
44	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.29498216
45	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27678969
46	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26401326
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26340472
48	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.25742164
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25165559
50	NCOR_22424771_ChIP-Seq_293T_Human	1.24413440
51	P300_19829295_ChIP-Seq_ESCs_Human	1.23704694
52	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23656793
53	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.23465787
54	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.23044462
55	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.22341924
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21055479
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21055479
58	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.20637470
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18740893
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15370077
61	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.14081252
62	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.13732019
63	ER_23166858_ChIP-Seq_MCF-7_Human	1.13228000
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11547869
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.11427675
66	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.10936428
67	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10761635
68	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09734757
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09483814
70	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07510653
71	ERG_20517297_ChIP-Seq_VCAP_Human	1.07059428
72	MYC_19829295_ChIP-Seq_ESCs_Human	1.06666406
73	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05877390
74	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05338979
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05036419
76	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.03906445
77	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.03842819
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03489738
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03489738
80	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.03398610
81	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02290903
82	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01461865
83	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.01461865
84	GATA3_26560356_Chip-Seq_TH2_Human	1.00182363
85	BCAT_22108803_ChIP-Seq_LS180_Human	0.99177619
86	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.98799124
87	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.97334508
88	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96657549
89	GBX2_23144817_ChIP-Seq_PC3_Human	0.94097027
90	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.94065855
91	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93846259
92	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.93410138
93	ERA_21632823_ChIP-Seq_H3396_Human	0.92943476
94	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91844120
95	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91602103
96	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90451742
97	CIITA_25753668_ChIP-Seq_RAJI_Human	0.90406342
98	OCT4_20526341_ChIP-Seq_ESCs_Human	0.89986511
99	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.88536415
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88298301

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.31802115
2	MP0006292_abnormal_olfactory_placode	3.37370839
3	MP0005671_abnormal_response_to	2.75300902
4	MP0005646_abnormal_pituitary_gland	2.67437516
5	MP0002653_abnormal_ependyma_morphology	2.45988317
6	MP0003787_abnormal_imprinting	2.37437904
7	MP0004885_abnormal_endolymph	2.35909572
8	MP0002102_abnormal_ear_morphology	2.28061604
9	MP0005551_abnormal_eye_electrophysiolog	2.12326215
10	MP0001968_abnormal_touch/_nociception	2.09704541
11	MP0008877_abnormal_DNA_methylation	2.08101102
12	MP0005377_hearing/vestibular/ear_phenot	2.06737221
13	MP0003878_abnormal_ear_physiology	2.06737221
14	MP0006072_abnormal_retinal_apoptosis	1.93356353
15	MP0003880_abnormal_central_pattern	1.89504046
16	MP0002736_abnormal_nociception_after	1.89418432
17	MP0008875_abnormal_xenobiotic_pharmacok	1.83058984
18	MP0008872_abnormal_physiological_respon	1.78531735
19	MP0004142_abnormal_muscle_tone	1.74557717
20	MP0003646_muscle_fatigue	1.74500084
21	MP0003122_maternal_imprinting	1.64186967
22	MP0004147_increased_porphyrin_level	1.61314448
23	MP0005645_abnormal_hypothalamus_physiol	1.58179007
24	MP0002163_abnormal_gland_morphology	1.56358536
25	MP0001485_abnormal_pinna_reflex	1.54190347
26	MP0001835_abnormal_antigen_presentation	1.50973368
27	MP0003121_genomic_imprinting	1.48669721
28	MP0002837_dystrophic_cardiac_calcinosis	1.47901717
29	MP0002138_abnormal_hepatobiliary_system	1.44738847
30	MP0001905_abnormal_dopamine_level	1.44444355
31	MP0003011_delayed_dark_adaptation	1.44079909
32	MP0002876_abnormal_thyroid_physiology	1.41390296
33	MP0005389_reproductive_system_phenotype	1.39083703
34	MP0002160_abnormal_reproductive_system	1.37877971
35	MP0002938_white_spotting	1.36902905
36	MP0002095_abnormal_skin_pigmentation	1.36471049
37	MP0001984_abnormal_olfaction	1.35628573
38	MP0004742_abnormal_vestibular_system	1.33336799
39	MP0008789_abnormal_olfactory_epithelium	1.31942558
40	MP0005253_abnormal_eye_physiology	1.30742472
41	MP0006276_abnormal_autonomic_nervous	1.30728903
42	MP0001293_anophthalmia	1.30482422
43	MP0000372_irregular_coat_pigmentation	1.27956095
44	MP0001919_abnormal_reproductive_system	1.27214334
45	MP0002272_abnormal_nervous_system	1.27040519
46	MP0002733_abnormal_thermal_nociception	1.25686580
47	MP0002638_abnormal_pupillary_reflex	1.24220534
48	MP0009764_decreased_sensitivity_to	1.24003401
49	MP0009785_altered_susceptibility_to	1.23275822
50	MP0002006_tumorigenesis	1.20318156
51	MP0000631_abnormal_neuroendocrine_gland	1.18576652
52	MP0005195_abnormal_posterior_eye	1.18395763
53	MP0005075_abnormal_melanosome_morpholog	1.17164380
54	MP0001970_abnormal_pain_threshold	1.13587001
55	MP0009745_abnormal_behavioral_response	1.11900785
56	MP0002166_altered_tumor_susceptibility	1.10883128
57	MP0008995_early_reproductive_senescence	1.09415324
58	MP0005410_abnormal_fertilization	1.09123563
59	MP0001986_abnormal_taste_sensitivity	1.01270345
60	MP0001800_abnormal_humoral_immune	0.98526614
61	MP0001486_abnormal_startle_reflex	0.98431431
62	MP0002277_abnormal_respiratory_mucosa	0.97218944
63	MP0000026_abnormal_inner_ear	0.93253960
64	MP0003806_abnormal_nucleotide_metabolis	0.90216091
65	MP0001963_abnormal_hearing_physiology	0.88791777
66	MP0000427_abnormal_hair_cycle	0.88590536
67	MP0002752_abnormal_somatic_nervous	0.87978910
68	MP0001661_extended_life_span	0.87617319
69	MP0002148_abnormal_hypersensitivity_rea	0.87364120
70	MP0001440_abnormal_grooming_behavior	0.86911673
71	MP0005084_abnormal_gallbladder_morpholo	0.86625280
72	MP0003195_calcinosis	0.86187148
73	MP0005379_endocrine/exocrine_gland_phen	0.85287508
74	MP0001529_abnormal_vocalization	0.85282257
75	MP0009046_muscle_twitch	0.85172614
76	MP0002557_abnormal_social/conspecific_i	0.84056516
77	MP0001501_abnormal_sleep_pattern	0.83530890
78	MP0000685_abnormal_immune_system	0.83262805
79	MP0005636_abnormal_mineral_homeostasis	0.83246736
80	MP0002723_abnormal_immune_serum	0.82942296
81	MP0005499_abnormal_olfactory_system	0.82446378
82	MP0005394_taste/olfaction_phenotype	0.82446378
83	MP0002234_abnormal_pharynx_morphology	0.81492672
84	MP0004145_abnormal_muscle_electrophysio	0.81007517
85	MP0003183_abnormal_peptide_metabolism	0.80197929
86	MP0000049_abnormal_middle_ear	0.77077232
87	MP0005000_abnormal_immune_tolerance	0.75883237
88	MP0001764_abnormal_homeostasis	0.75266689
89	MP0002735_abnormal_chemical_nociception	0.74682366
90	MP0002572_abnormal_emotion/affect_behav	0.74670384
91	MP0000230_abnormal_systemic_arterial	0.74511144
92	MP0002210_abnormal_sex_determination	0.74485883
93	MP0009333_abnormal_splenocyte_physiolog	0.74192556
94	MP0005360_urolithiasis	0.73466134
95	MP0008058_abnormal_DNA_repair	0.73077125
96	MP0002420_abnormal_adaptive_immunity	0.71557224
97	MP0003638_abnormal_response/metabolism_	0.70007377
98	MP0003123_paternal_imprinting	0.69889840
99	MP0000778_abnormal_nervous_system	0.69830440
100	MP0005391_vision/eye_phenotype	0.69434278

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.49440631
2	Acute necrotizing encephalopathy (HP:0006965)	4.03435180
3	Pancreatic fibrosis (HP:0100732)	3.84938659
4	Mitochondrial inheritance (HP:0001427)	3.82856851
5	Reticulocytopenia (HP:0001896)	3.73719593
6	Abnormal rod and cone electroretinograms (HP:0008323)	3.68357257
7	Abnormality of cells of the erythroid lineage (HP:0012130)	3.66124095
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.59322890
9	Pancreatic cysts (HP:0001737)	3.56698170
10	Progressive macrocephaly (HP:0004481)	3.47646581
11	True hermaphroditism (HP:0010459)	3.39239426
12	Abnormality of midbrain morphology (HP:0002418)	3.33325436
13	Molar tooth sign on MRI (HP:0002419)	3.33325436
14	Increased CSF lactate (HP:0002490)	3.21113455
15	Acute encephalopathy (HP:0006846)	3.20253311
16	Abolished electroretinogram (ERG) (HP:0000550)	3.16421473
17	Hepatocellular necrosis (HP:0001404)	3.11986207
18	Decreased central vision (HP:0007663)	3.10693300
19	Elevated erythrocyte sedimentation rate (HP:0003565)	3.01753162
20	Abnormal number of erythroid precursors (HP:0012131)	2.99949894
21	Attenuation of retinal blood vessels (HP:0007843)	2.96147381
22	Absent thumb (HP:0009777)	2.94188932
23	Congenital stationary night blindness (HP:0007642)	2.94047042
24	Nephronophthisis (HP:0000090)	2.85751568
25	Polydipsia (HP:0001959)	2.82445852
26	Abnormal drinking behavior (HP:0030082)	2.82445852
27	Renal Fanconi syndrome (HP:0001994)	2.78904406
28	Hepatic necrosis (HP:0002605)	2.67754559
29	Increased hepatocellular lipid droplets (HP:0006565)	2.66690135
30	Macrocytic anemia (HP:0001972)	2.64627858
31	IgG deficiency (HP:0004315)	2.62981756
32	Cerebral edema (HP:0002181)	2.62709857
33	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.59097107
34	Lipid accumulation in hepatocytes (HP:0006561)	2.58036759
35	Pendular nystagmus (HP:0012043)	2.52001519
36	Type II lissencephaly (HP:0007260)	2.48065374
37	Optic disc pallor (HP:0000543)	2.44544224
38	Abnormality of the renal medulla (HP:0100957)	2.42275635
39	Pallor (HP:0000980)	2.42146091
40	Constricted visual fields (HP:0001133)	2.40727429
41	Stenosis of the external auditory canal (HP:0000402)	2.40574573
42	Septo-optic dysplasia (HP:0100842)	2.38741294
43	Medial flaring of the eyebrow (HP:0010747)	2.36086195
44	Cystic liver disease (HP:0006706)	2.32840339
45	Sclerocornea (HP:0000647)	2.28301491
46	Tubular atrophy (HP:0000092)	2.27824014
47	Methylmalonic acidemia (HP:0002912)	2.26609705
48	3-Methylglutaconic aciduria (HP:0003535)	2.25685833
49	Absent/shortened dynein arms (HP:0200106)	2.24999154
50	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.24999154
51	Chronic hepatic failure (HP:0100626)	2.24484458
52	Polyuria (HP:0000103)	2.24249775
53	Abnormality of the renal cortex (HP:0011035)	2.21447269
54	Increased IgM level (HP:0003496)	2.17731497
55	Thyroid-stimulating hormone excess (HP:0002925)	2.17430285
56	Aplastic anemia (HP:0001915)	2.13266707
57	Increased serum lactate (HP:0002151)	2.12350322
58	Anencephaly (HP:0002323)	2.02874405
59	Increased intramyocellular lipid droplets (HP:0012240)	2.01812384
60	Abnormal respiratory epithelium morphology (HP:0012253)	2.01779211
61	Abnormal respiratory motile cilium morphology (HP:0005938)	2.01779211
62	Abnormality of renal resorption (HP:0011038)	2.01150308
63	Hypoproteinemia (HP:0003075)	2.01003835
64	Colon cancer (HP:0003003)	2.00957025
65	Abnormal ciliary motility (HP:0012262)	1.97432430
66	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.96931259
67	Abnormality of alanine metabolism (HP:0010916)	1.96931259
68	Hyperalaninemia (HP:0003348)	1.96931259
69	Lactic acidosis (HP:0003128)	1.95928458
70	Asplenia (HP:0001746)	1.93885590
71	Optic nerve hypoplasia (HP:0000609)	1.93153689
72	Methylmalonic aciduria (HP:0012120)	1.92249058
73	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.90888021
74	Abnormal respiratory motile cilium physiology (HP:0012261)	1.90845706
75	Congenital, generalized hypertrichosis (HP:0004540)	1.87541909
76	Nephrogenic diabetes insipidus (HP:0009806)	1.85643897
77	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.82787740
78	Abnormality of the ileum (HP:0001549)	1.80880140
79	Hyperglycinemia (HP:0002154)	1.80845219
80	Dyschromatopsia (HP:0007641)	1.80730141
81	Abnormal urine output (HP:0012590)	1.80704985
82	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.80252790
83	Male pseudohermaphroditism (HP:0000037)	1.78541686
84	Triphalangeal thumb (HP:0001199)	1.77938812
85	Diastasis recti (HP:0001540)	1.77891374
86	Increased corneal curvature (HP:0100692)	1.77618294
87	Keratoconus (HP:0000563)	1.77618294
88	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.77506944
89	Pancytopenia (HP:0001876)	1.76915868
90	Abnormality of cochlea (HP:0000375)	1.75161004
91	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.74283744
92	Gait imbalance (HP:0002141)	1.73550901
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.73162419
94	Congenital primary aphakia (HP:0007707)	1.72545358
95	Hypoplasia of the radius (HP:0002984)	1.72475343
96	Absent septum pellucidum (HP:0001331)	1.72142257
97	Cerebellar dysplasia (HP:0007033)	1.72063043
98	Chorioretinal atrophy (HP:0000533)	1.71989072
99	Leukodystrophy (HP:0002415)	1.71513709
100	Ketosis (HP:0001946)	1.71294456

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.50829186
2	ADRBK2	3.32065752
3	CDK19	3.19780085
4	KDR	2.96876752
5	TAOK3	2.73939296
6	TLK1	2.61225373
7	MAP4K2	2.51961643
8	TXK	2.50757498
9	WNK4	2.48322013
10	ZAK	2.46339704
11	BCKDK	2.31697693
12	GRK1	2.14286614
13	NUAK1	2.03882608
14	TESK2	1.84419293
15	VRK2	1.83520280
16	STK16	1.62303472
17	PINK1	1.55164010
18	PASK	1.51543417
19	CAMKK2	1.46329363
20	CDC7	1.45545292
21	LIMK1	1.44559359
22	WNK3	1.44149382
23	OXSR1	1.43956418
24	VRK1	1.42287616
25	MAP4K1	1.39306395
26	DYRK2	1.36676804
27	TIE1	1.19207051
28	ADRBK1	1.18618798
29	INSRR	1.17372381
30	PRKCQ	1.14249168
31	TEC	1.13064688
32	ITK	1.09135523
33	KIT	1.05581117
34	NME1	1.01518336
35	MUSK	1.00580973
36	PIK3CA	0.93479957
37	TRIM28	0.92502940
38	CAMKK1	0.91772275
39	BMPR1B	0.90255470
40	STK39	0.87046693
41	GRK7	0.86219988
42	SYK	0.86180027
43	FES	0.86148900
44	PRKCG	0.83255187
45	MAP3K11	0.79873408
46	CAMK1	0.77205306
47	LCK	0.76991557
48	TNK2	0.75786701
49	MAP2K7	0.75496381
50	GRK6	0.75097003
51	STK38L	0.72432632
52	MAPK13	0.70941851
53	NLK	0.70924526
54	BTK	0.69964819
55	DAPK2	0.69255077
56	MARK3	0.68869764
57	GRK5	0.68484279
58	IKBKE	0.66285541
59	TYRO3	0.65793203
60	RPS6KB2	0.65766891
61	IKBKB	0.65602694
62	WNK1	0.65543696
63	RPS6KA5	0.62588188
64	MAP3K12	0.62050195
65	PLK4	0.61930991
66	LRRK2	0.61453736
67	MAPKAPK3	0.61271892
68	NTRK2	0.58656714
69	STK11	0.58012707
70	PIK3CG	0.57990103
71	AURKA	0.56694943
72	DAPK1	0.55575143
73	OBSCN	0.52617948
74	BMPR2	0.51787744
75	AURKB	0.51370394
76	PRKCA	0.50972120
77	PRKACA	0.50566912
78	EIF2AK3	0.50397793
79	PRKCH	0.49994588
80	PIM1	0.49883653
81	LYN	0.49113845
82	PRKCE	0.46401104
83	DAPK3	0.45720402
84	JAK3	0.44002371
85	EIF2AK1	0.43244398
86	CASK	0.42875923
87	NEK2	0.42805888
88	TAF1	0.42490380
89	CSNK2A2	0.41954335
90	PLK1	0.41714544
91	RPS6KA6	0.41525729
92	MAP3K4	0.39622897
93	TGFBR1	0.38959181
94	ATR	0.38694432
95	SGK494	0.37956564
96	SGK223	0.37956564
97	CSF1R	0.37173789
98	CSNK1A1	0.36808243
99	TRPM7	0.35138326
100	CAMK2A	0.34819118

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.68729532
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.75426169
3	Parkinsons disease_Homo sapiens_hsa05012	3.06353041
4	Proteasome_Homo sapiens_hsa03050	3.03083596
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.72495663
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.03525800
7	Huntingtons disease_Homo sapiens_hsa05016	2.03472788
8	Alzheimers disease_Homo sapiens_hsa05010	2.01339428
9	Phototransduction_Homo sapiens_hsa04744	2.00535093
10	Asthma_Homo sapiens_hsa05310	2.00388518
11	Cardiac muscle contraction_Homo sapiens_hsa04260	1.94045527
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.92295646
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.90792923
14	Allograft rejection_Homo sapiens_hsa05330	1.86812620
15	RNA polymerase_Homo sapiens_hsa03020	1.86113094
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84398611
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.81961682
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.79888013
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.74322957
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.70570142
21	One carbon pool by folate_Homo sapiens_hsa00670	1.65921417
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.59578093
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.58872208
24	RNA degradation_Homo sapiens_hsa03018	1.58130364
25	Protein export_Homo sapiens_hsa03060	1.55876066
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.52061777
27	Homologous recombination_Homo sapiens_hsa03440	1.51938705
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.49844029
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.45543527
30	Antigen processing and presentation_Homo sapiens_hsa04612	1.42533586
31	DNA replication_Homo sapiens_hsa03030	1.38595251
32	Butanoate metabolism_Homo sapiens_hsa00650	1.36136015
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.34292107
34	Caffeine metabolism_Homo sapiens_hsa00232	1.30485477
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.26854898
36	Olfactory transduction_Homo sapiens_hsa04740	1.15050597
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.12942886
38	Basal transcription factors_Homo sapiens_hsa03022	1.12360235
39	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.08270393
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.06945859
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.05424815
42	Peroxisome_Homo sapiens_hsa04146	1.03040288
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02949623
44	Ether lipid metabolism_Homo sapiens_hsa00565	1.01643871
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.95780033
46	Mismatch repair_Homo sapiens_hsa03430	0.94191735
47	Nicotine addiction_Homo sapiens_hsa05033	0.94100554
48	Morphine addiction_Homo sapiens_hsa05032	0.93092175
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90161465
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89970938
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89798378
52	Regulation of autophagy_Homo sapiens_hsa04140	0.88189243
53	Retinol metabolism_Homo sapiens_hsa00830	0.88125221
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84942986
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.83382594
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82798106
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81492138
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.80620489
59	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79013056
60	Purine metabolism_Homo sapiens_hsa00230	0.78879062
61	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.77432100
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76580042
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.76527009
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.74774272
65	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.70933210
66	Selenocompound metabolism_Homo sapiens_hsa00450	0.69920870
67	Taste transduction_Homo sapiens_hsa04742	0.69899457
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69864141
69	Propanoate metabolism_Homo sapiens_hsa00640	0.68376733
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64667089
71	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.63967922
72	Base excision repair_Homo sapiens_hsa03410	0.63832541
73	Sulfur relay system_Homo sapiens_hsa04122	0.62678164
74	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.59582718
75	Spliceosome_Homo sapiens_hsa03040	0.56463361
76	Metabolic pathways_Homo sapiens_hsa01100	0.55951319
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53527754
78	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.51172606
79	Sulfur metabolism_Homo sapiens_hsa00920	0.49892888
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.47164518
81	Fatty acid degradation_Homo sapiens_hsa00071	0.46003638
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45963341
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44427687
84	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43178239
85	GABAergic synapse_Homo sapiens_hsa04727	0.42750833
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40123695
87	Serotonergic synapse_Homo sapiens_hsa04726	0.39158176
88	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.38784905
89	Circadian entrainment_Homo sapiens_hsa04713	0.38535784
90	RNA transport_Homo sapiens_hsa03013	0.37363285
91	Viral myocarditis_Homo sapiens_hsa05416	0.36954264
92	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.36351999
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.35753202
94	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.34279013
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.33599895
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.30779918
97	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.29992353
98	Salivary secretion_Homo sapiens_hsa04970	0.27949218
99	Basal cell carcinoma_Homo sapiens_hsa05217	0.27411650
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.26312937

RPL10AP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »