RPL10AP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.27304701
2DNA deamination (GO:0045006)6.62427123
3ribosomal small subunit biogenesis (GO:0042274)6.12723217
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.75203272
5viral transcription (GO:0019083)5.57800850
6cytidine metabolic process (GO:0046087)5.37125536
7cytidine catabolic process (GO:0006216)5.37125536
8cytidine deamination (GO:0009972)5.37125536
9translational termination (GO:0006415)5.32635698
10ATP synthesis coupled proton transport (GO:0015986)5.01718646
11energy coupled proton transport, down electrochemical gradient (GO:0015985)5.01718646
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.99010334
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.91296009
14translational elongation (GO:0006414)4.90025255
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.79291669
16maturation of SSU-rRNA (GO:0030490)4.74229412
17cotranslational protein targeting to membrane (GO:0006613)4.68392490
18protein targeting to ER (GO:0045047)4.65139981
19pyrimidine ribonucleoside catabolic process (GO:0046133)4.54091197
20protein localization to endoplasmic reticulum (GO:0070972)4.43844817
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.43262450
22respiratory electron transport chain (GO:0022904)4.28210040
23electron transport chain (GO:0022900)4.23210725
24ribosomal large subunit biogenesis (GO:0042273)4.09118987
25cellular protein complex disassembly (GO:0043624)4.04797345
26viral life cycle (GO:0019058)3.99638114
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.96188995
28ncRNA 3-end processing (GO:0043628)3.87024931
29protein complex biogenesis (GO:0070271)3.86027007
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.81008409
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.66935984
32translational initiation (GO:0006413)3.64386416
33base-excision repair, AP site formation (GO:0006285)3.54160249
34chaperone-mediated protein transport (GO:0072321)3.54020117
35protein neddylation (GO:0045116)3.53778357
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.51240730
37negative regulation of T cell apoptotic process (GO:0070233)3.49993187
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.48285956
39NADH dehydrogenase complex assembly (GO:0010257)3.48285956
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.48285956
41water-soluble vitamin biosynthetic process (GO:0042364)3.47064712
42deoxyribonucleotide catabolic process (GO:0009264)3.46991144
43purine deoxyribonucleotide catabolic process (GO:0009155)3.45448398
44mitochondrial respiratory chain complex assembly (GO:0033108)3.42311423
45regulation of regulatory T cell differentiation (GO:0045589)3.41295323
46translation (GO:0006412)3.39798715
47Arp2/3 complex-mediated actin nucleation (GO:0034314)3.37907107
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36691166
49protein complex disassembly (GO:0043241)3.30189490
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.28923149
51sequestering of actin monomers (GO:0042989)3.24756569
52deoxyribose phosphate catabolic process (GO:0046386)3.24610416
53cellular component biogenesis (GO:0044085)3.21024150
54pyrimidine nucleotide catabolic process (GO:0006244)3.19588234
55macromolecular complex disassembly (GO:0032984)3.12327666
56ribonucleoprotein complex biogenesis (GO:0022613)3.12130280
57actin nucleation (GO:0045010)3.11614022
58positive T cell selection (GO:0043368)3.08611163
59platelet dense granule organization (GO:0060155)3.07604527
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.03141138
61positive thymic T cell selection (GO:0045059)3.00408236
62protein targeting to membrane (GO:0006612)2.97285531
63metallo-sulfur cluster assembly (GO:0031163)2.97199372
64iron-sulfur cluster assembly (GO:0016226)2.97199372
65transcription elongation from RNA polymerase III promoter (GO:0006385)2.93464201
66termination of RNA polymerase III transcription (GO:0006386)2.93464201
67nuclear-transcribed mRNA catabolic process (GO:0000956)2.88465672
68hydrogen ion transmembrane transport (GO:1902600)2.87829152
69negative regulation of lymphocyte apoptotic process (GO:0070229)2.85787428
70ATP biosynthetic process (GO:0006754)2.84946932
71deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.78132475
72positive regulation of calcium-mediated signaling (GO:0050850)2.77967640
73purine nucleotide salvage (GO:0032261)2.75571775
74purine-containing compound salvage (GO:0043101)2.74037461
75pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.72547763
76regulation of cellular amino acid metabolic process (GO:0006521)2.71672884
77purine nucleoside triphosphate biosynthetic process (GO:0009145)2.70347246
78proton transport (GO:0015992)2.69822367
79mRNA catabolic process (GO:0006402)2.69503134
80pseudouridine synthesis (GO:0001522)2.68699848
81purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.68071477
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.66549313
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66375251
84hydrogen transport (GO:0006818)2.64747062
85pyrimidine nucleoside catabolic process (GO:0046135)2.62886532
86purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.61601344
87regulation of T cell apoptotic process (GO:0070232)2.60827821
88positive regulation of defense response to virus by host (GO:0002230)2.60408794
89cytochrome complex assembly (GO:0017004)2.59633998
902-deoxyribonucleotide metabolic process (GO:0009394)2.57201077
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.56437691
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.56437691
93signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.56437691
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56047114
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56047114
96negative T cell selection (GO:0043383)2.55347911
97intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.54732775
98signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.54732775
99behavioral response to nicotine (GO:0035095)2.54664973
100respiratory chain complex IV assembly (GO:0008535)2.54019089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.25011005
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.92705348
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.71907336
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.36606710
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05318041
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.99622992
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77235561
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73571853
9EZH2_22144423_ChIP-Seq_EOC_Human2.70349050
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69128273
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.60903920
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52111986
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.49734639
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42011586
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.37345083
16VDR_22108803_ChIP-Seq_LS180_Human2.35883987
17VDR_23849224_ChIP-Seq_CD4+_Human2.32581562
18ZNF274_21170338_ChIP-Seq_K562_Hela2.29720887
19IGF1R_20145208_ChIP-Seq_DFB_Human2.00696009
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84779118
21FOXP3_21729870_ChIP-Seq_TREG_Human1.82032167
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81392608
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77855481
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.67265059
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.65230583
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63476219
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56511955
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56180159
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54622574
30ELK1_19687146_ChIP-ChIP_HELA_Human1.54190740
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52074349
32TP53_22573176_ChIP-Seq_HFKS_Human1.49371945
33MYC_18940864_ChIP-ChIP_HL60_Human1.47922657
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.47422938
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.46651946
36PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.45771710
37RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.44531586
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42471532
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.40154613
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39658388
41AR_20517297_ChIP-Seq_VCAP_Human1.34901715
42NANOG_20526341_ChIP-Seq_ESCs_Human1.34342455
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34177983
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33242631
45MYB_26560356_Chip-Seq_TH2_Human1.33041382
46EWS_26573619_Chip-Seq_HEK293_Human1.32273185
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.32073094
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31733923
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31316892
50TAF2_19829295_ChIP-Seq_ESCs_Human1.31159116
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26643977
52NCOR_22424771_ChIP-Seq_293T_Human1.25626944
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25567936
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.25166094
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25166094
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24690244
57GATA3_26560356_Chip-Seq_TH2_Human1.24670678
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.22867668
59BCL6_27268052_Chip-Seq_Bcells_Human1.22015794
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20621998
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19381883
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.14784664
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13667741
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12808835
65ERA_21632823_ChIP-Seq_H3396_Human1.11274529
66P300_27268052_Chip-Seq_Bcells_Human1.10304130
67GATA3_27048872_Chip-Seq_THYMUS_Human1.08779910
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08117468
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07370512
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06748746
71CIITA_25753668_ChIP-Seq_RAJI_Human1.06295347
72HTT_18923047_ChIP-ChIP_STHdh_Human1.05412652
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04524907
74GABP_19822575_ChIP-Seq_HepG2_Human1.04489325
75FUS_26573619_Chip-Seq_HEK293_Human1.03263158
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.03028090
77FOXH1_21741376_ChIP-Seq_EPCs_Human1.02815109
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02307036
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01838763
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01627801
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00873377
82TTF2_22483619_ChIP-Seq_HELA_Human0.98907060
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98900232
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98609329
85PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98503140
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.98366233
87CTCF_20526341_ChIP-Seq_ESCs_Human0.98363964
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98136286
89NANOG_19829295_ChIP-Seq_ESCs_Human0.97229553
90SOX2_19829295_ChIP-Seq_ESCs_Human0.97229553
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96573359
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95868571
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95491343
94XRN2_22483619_ChIP-Seq_HELA_Human0.94661132
95E2F1_20622854_ChIP-Seq_HELA_Human0.93697711
96STAT1_20625510_ChIP-Seq_HELA_Human0.93575835
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92785212
98ERG_20517297_ChIP-Seq_VCAP_Human0.91637948
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91283925
100CBP_20019798_ChIP-Seq_JUKART_Human0.91245065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.59896988
2MP0009379_abnormal_foot_pigmentation4.52212460
3MP0001835_abnormal_antigen_presentation2.92567544
4MP0006292_abnormal_olfactory_placode2.77886499
5MP0009785_altered_susceptibility_to2.46924835
6MP0001873_stomach_inflammation2.29224216
7MP0005646_abnormal_pituitary_gland2.11781833
8MP0003646_muscle_fatigue2.06739144
9MP0005645_abnormal_hypothalamus_physiol1.97484968
10MP0002163_abnormal_gland_morphology1.97013332
11MP0002148_abnormal_hypersensitivity_rea1.86839731
12MP0003763_abnormal_thymus_physiology1.79462103
13MP0001800_abnormal_humoral_immune1.75365288
14MP0002102_abnormal_ear_morphology1.73663198
15MP0002876_abnormal_thyroid_physiology1.71396837
16MP0004147_increased_porphyrin_level1.69828583
17MP0006072_abnormal_retinal_apoptosis1.68584669
18MP0008872_abnormal_physiological_respon1.66550794
19MP0008875_abnormal_xenobiotic_pharmacok1.66235840
20MP0006082_CNS_inflammation1.65455909
21MP0005000_abnormal_immune_tolerance1.63499670
22MP0000685_abnormal_immune_system1.63305190
23MP0000372_irregular_coat_pigmentation1.63029363
24MP0009333_abnormal_splenocyte_physiolog1.60570434
25MP0002160_abnormal_reproductive_system1.57370132
26MP0002138_abnormal_hepatobiliary_system1.56797007
27MP0005551_abnormal_eye_electrophysiolog1.55160130
28MP0001968_abnormal_touch/_nociception1.53706763
29MP0002837_dystrophic_cardiac_calcinosis1.50654070
30MP0008058_abnormal_DNA_repair1.50274278
31MP0001905_abnormal_dopamine_level1.50212623
32MP0002420_abnormal_adaptive_immunity1.49439096
33MP0002723_abnormal_immune_serum1.48438897
34MP0001819_abnormal_immune_cell1.46372516
35MP0005389_reproductive_system_phenotype1.44038947
36MP0002736_abnormal_nociception_after1.43337500
37MP0003866_abnormal_defecation1.40349659
38MP0008789_abnormal_olfactory_epithelium1.40325235
39MP0002234_abnormal_pharynx_morphology1.39064157
40MP0002166_altered_tumor_susceptibility1.38350594
41MP0008877_abnormal_DNA_methylation1.38028930
42MP0005025_abnormal_response_to1.37912880
43MP0003878_abnormal_ear_physiology1.37384159
44MP0005377_hearing/vestibular/ear_phenot1.37384159
45MP0005387_immune_system_phenotype1.37024345
46MP0001790_abnormal_immune_system1.37024345
47MP0002095_abnormal_skin_pigmentation1.35487182
48MP0004885_abnormal_endolymph1.35323169
49MP0005084_abnormal_gallbladder_morpholo1.34267242
50MP0005075_abnormal_melanosome_morpholog1.32393879
51MP0002452_abnormal_antigen_presenting1.28832077
52MP0002277_abnormal_respiratory_mucosa1.27706158
53MP0004145_abnormal_muscle_electrophysio1.27675264
54MP0001986_abnormal_taste_sensitivity1.26929887
55MP0002006_tumorigenesis1.24848007
56MP0006276_abnormal_autonomic_nervous1.23858826
57MP0001919_abnormal_reproductive_system1.22168608
58MP0005379_endocrine/exocrine_gland_phen1.19541520
59MP0004142_abnormal_muscle_tone1.16997866
60MP0000716_abnormal_immune_system1.16707067
61MP0002398_abnormal_bone_marrow1.14363441
62MP0002933_joint_inflammation1.13991188
63MP0003786_premature_aging1.12805193
64MP0003787_abnormal_imprinting1.10055474
65MP0003806_abnormal_nucleotide_metabolis1.08747553
66MP0002405_respiratory_system_inflammati1.06190741
67MP0000689_abnormal_spleen_morphology1.06150361
68MP0006036_abnormal_mitochondrial_physio1.02970599
69MP0002653_abnormal_ependyma_morphology0.99667996
70MP0000703_abnormal_thymus_morphology0.99636207
71MP0008995_early_reproductive_senescence0.99227311
72MP0009764_decreased_sensitivity_to0.95250570
73MP0005410_abnormal_fertilization0.94383410
74MP0000631_abnormal_neuroendocrine_gland0.93056759
75MP0002722_abnormal_immune_system0.92897941
76MP0010155_abnormal_intestine_physiology0.91766234
77MP0005253_abnormal_eye_physiology0.89254055
78MP0001764_abnormal_homeostasis0.89033637
79MP0002429_abnormal_blood_cell0.88773086
80MP0003011_delayed_dark_adaptation0.87607123
81MP0002272_abnormal_nervous_system0.86001454
82MP0005636_abnormal_mineral_homeostasis0.85548532
83MP0001485_abnormal_pinna_reflex0.83867198
84MP0002733_abnormal_thermal_nociception0.83543040
85MP0001663_abnormal_digestive_system0.82099986
86MP0001845_abnormal_inflammatory_respons0.80963901
87MP0001970_abnormal_pain_threshold0.80302692
88MP0002693_abnormal_pancreas_physiology0.79808095
89MP0003252_abnormal_bile_duct0.78442988
90MP0003879_abnormal_hair_cell0.78193821
91MP0002132_abnormal_respiratory_system0.77678203
92MP0005499_abnormal_olfactory_system0.77583689
93MP0005394_taste/olfaction_phenotype0.77583689
94MP0003121_genomic_imprinting0.77006224
95MP0005174_abnormal_tail_pigmentation0.73839685
96MP0002822_catalepsy0.73198849
97MP0001765_abnormal_ion_homeostasis0.72534596
98MP0001293_anophthalmia0.72337222
99MP0005085_abnormal_gallbladder_physiolo0.71105858
100MP0002419_abnormal_innate_immunity0.70463983

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.81814257
2Mitochondrial inheritance (HP:0001427)4.50107901
3Abnormal mitochondria in muscle tissue (HP:0008316)4.46324370
43-Methylglutaconic aciduria (HP:0003535)4.08874858
5Acute encephalopathy (HP:0006846)4.01113500
6Progressive macrocephaly (HP:0004481)3.98777126
7Increased hepatocellular lipid droplets (HP:0006565)3.94796127
8Increased CSF lactate (HP:0002490)3.88133967
9Elevated erythrocyte sedimentation rate (HP:0003565)3.87250504
10Aplastic anemia (HP:0001915)3.83615018
11Congenital stationary night blindness (HP:0007642)3.59954617
12Hepatocellular necrosis (HP:0001404)3.58490101
13Increased intramyocellular lipid droplets (HP:0012240)3.55010819
14Lipid accumulation in hepatocytes (HP:0006561)3.50098733
15Renal Fanconi syndrome (HP:0001994)3.43880656
16Severe combined immunodeficiency (HP:0004430)3.38145064
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.24361004
18Constricted visual fields (HP:0001133)3.21995318
19Decreased electroretinogram (ERG) amplitude (HP:0000654)3.20162158
20Hepatic necrosis (HP:0002605)3.17620362
21Cerebral edema (HP:0002181)3.16791948
22Reticulocytopenia (HP:0001896)3.09486539
23Attenuation of retinal blood vessels (HP:0007843)3.04573487
24Optic disc pallor (HP:0000543)3.04112156
25Abnormality of B cell number (HP:0010975)3.04054690
26Abnormality of cells of the erythroid lineage (HP:0012130)2.97354842
27Increased muscle lipid content (HP:0009058)2.88606715
28Hypoproteinemia (HP:0003075)2.86148485
29Autoimmune hemolytic anemia (HP:0001890)2.81761158
30IgG deficiency (HP:0004315)2.73741458
31Abnormality of midbrain morphology (HP:0002418)2.71583514
32Molar tooth sign on MRI (HP:0002419)2.71583514
33Pancreatic cysts (HP:0001737)2.67469903
34Abnormal rod and cone electroretinograms (HP:0008323)2.67295726
35B lymphocytopenia (HP:0010976)2.65700830
36Abnormal number of erythroid precursors (HP:0012131)2.65502132
37Macrocytic anemia (HP:0001972)2.63666749
38Methylmalonic acidemia (HP:0002912)2.61488158
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61118978
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61118978
41Thyroiditis (HP:0100646)2.58615388
42Exertional dyspnea (HP:0002875)2.54194729
43Increased serum lactate (HP:0002151)2.51867853
44Lactic acidosis (HP:0003128)2.49139885
45Combined immunodeficiency (HP:0005387)2.47086202
46Abnormality of T cell number (HP:0011839)2.44936278
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.43530130
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37724813
49T lymphocytopenia (HP:0005403)2.34248667
50Abolished electroretinogram (ERG) (HP:0000550)2.33438558
51Abnormality of the prostate (HP:0008775)2.33412702
52Congenital, generalized hypertrichosis (HP:0004540)2.26823178
53Pancreatic fibrosis (HP:0100732)2.26389661
54Absent/shortened dynein arms (HP:0200106)2.26238733
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.26238733
56Type I transferrin isoform profile (HP:0003642)2.20706159
57Hyperglycinemia (HP:0002154)2.20258339
58True hermaphroditism (HP:0010459)2.20001552
59Lethargy (HP:0001254)2.17542663
60Abnormality of eosinophils (HP:0001879)2.17482267
61Abnormality of macular pigmentation (HP:0008002)2.16225973
62Abnormal respiratory motile cilium morphology (HP:0005938)2.15162962
63Abnormal respiratory epithelium morphology (HP:0012253)2.15162962
64Eosinophilia (HP:0001880)2.14041864
65Exercise intolerance (HP:0003546)2.13664786
66Colon cancer (HP:0003003)2.13324792
67Respiratory failure (HP:0002878)2.13003607
68Pallor (HP:0000980)2.11809661
69Panhypogammaglobulinemia (HP:0003139)2.11634522
70Abnormality of renal resorption (HP:0011038)2.10564526
71Pancytopenia (HP:0001876)2.09612501
72Autoimmune thrombocytopenia (HP:0001973)2.08945457
73Abnormality of T cells (HP:0002843)2.05666788
74Abnormal protein glycosylation (HP:0012346)2.03781603
75Abnormal glycosylation (HP:0012345)2.03781603
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03781603
77Abnormal protein N-linked glycosylation (HP:0012347)2.03781603
78Methylmalonic aciduria (HP:0012120)1.99710378
79Leukodystrophy (HP:0002415)1.95773017
80Stomatitis (HP:0010280)1.94676694
81Abnormal respiratory motile cilium physiology (HP:0012261)1.93612650
82Respiratory difficulties (HP:0002880)1.92642362
83Increased IgM level (HP:0003496)1.91873027
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90762676
85Type 2 muscle fiber atrophy (HP:0003554)1.90565320
86Abnormality of urine glucose concentration (HP:0011016)1.90421432
87Glycosuria (HP:0003076)1.90421432
88Absent thumb (HP:0009777)1.88406780
89Asplenia (HP:0001746)1.84227477
90Hyperphosphaturia (HP:0003109)1.83786531
91Type II lissencephaly (HP:0007260)1.83610315
92Pendular nystagmus (HP:0012043)1.82931682
93Ketosis (HP:0001946)1.82904077
94Aplasia/Hypoplasia of the spleen (HP:0010451)1.82873809
95Cerebral palsy (HP:0100021)1.80556396
96Abnormal ciliary motility (HP:0012262)1.79310908
97Decreased central vision (HP:0007663)1.76554229
98Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73936044
99Emotional lability (HP:0000712)1.71774406
100Prostate neoplasm (HP:0100787)1.71368117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.02577040
2TESK23.85311093
3TXK3.64289377
4BCKDK3.60263623
5MAP4K23.04289777
6ZAK2.85134247
7VRK22.82547423
8KIT2.34273950
9TLK12.28969295
10STK162.26726953
11TAOK32.26451776
12ADRBK22.12421777
13MAP4K12.10529899
14GRK12.03860630
15FES2.03184509
16TEC1.94581688
17MAP3K121.89666952
18SCYL21.87587570
19CDK191.86550055
20LIMK11.80009948
21VRK11.70914967
22PINK11.59153104
23TIE11.57327466
24ITK1.51802022
25NUAK11.43701184
26WNK41.41386044
27SYK1.38056807
28FRK1.36807698
29PASK1.35793740
30NME21.34382011
31CAMKK21.14580031
32PRKCQ1.11910771
33IKBKB1.11874185
34MUSK1.11786429
35TESK11.08791437
36BTK1.06079701
37MAP3K111.00595303
38LCK0.97877146
39PIM20.90926617
40DYRK20.79959641
41BUB10.78780508
42MAPKAPK30.78678547
43RPS6KA50.77999441
44LYN0.76486201
45CSK0.75251924
46TNK20.75222053
47DAPK10.73825479
48CAMKK10.71139933
49INSRR0.69904863
50PIK3CA0.69652473
51ADRBK10.69321574
52GRK60.68891891
53MAP2K70.67508373
54EIF2AK30.66806033
55PIK3CG0.66478620
56MAPKAPK50.66092431
57AURKA0.65905377
58GRK70.64317916
59MST40.61493123
60MYLK0.61236451
61CSF1R0.60698470
62WNK30.60583552
63OBSCN0.59017210
64PLK40.58155527
65TAF10.54942706
66NME10.54499191
67IKBKE0.52521247
68DAPK30.51798714
69CSNK1G30.51690704
70OXSR10.51229571
71LRRK20.49803230
72PIM10.49252328
73ABL20.47595393
74TYRO30.46515044
75PRKACA0.46207793
76BMPR1B0.43063137
77MAPK130.42751999
78PRKCA0.41958537
79CSNK2A20.41706801
80CSNK2A10.41690130
81STK390.40842265
82MAP2K60.40811515
83MAP3K50.39514058
84RPS6KB20.38915723
85CSNK1G20.38164565
86PRKCI0.36115771
87MATK0.36064086
88IGF1R0.34865005
89GRK50.34554192
90INSR0.32567253
91DAPK20.32373480
92CSNK1A10.32353394
93PRKCG0.31807658
94RPS6KA40.31649791
95ZAP700.31647576
96CSNK1G10.30966840
97CAMK10.30086175
98CSNK1A1L0.29354398
99AURKB0.29028422
100EIF2AK10.28823772

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.83024386
2Oxidative phosphorylation_Homo sapiens_hsa001904.22808289
3Proteasome_Homo sapiens_hsa030503.66566396
4Parkinsons disease_Homo sapiens_hsa050123.40075592
5Primary immunodeficiency_Homo sapiens_hsa053403.32286597
6Graft-versus-host disease_Homo sapiens_hsa053322.62399361
7Allograft rejection_Homo sapiens_hsa053302.40723664
8Autoimmune thyroid disease_Homo sapiens_hsa053202.37135646
9Alzheimers disease_Homo sapiens_hsa050102.34430287
10Asthma_Homo sapiens_hsa053102.31856627
11Huntingtons disease_Homo sapiens_hsa050162.23029132
12RNA polymerase_Homo sapiens_hsa030202.18470279
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.16266442
14Antigen processing and presentation_Homo sapiens_hsa046122.01969142
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.99955149
16Type I diabetes mellitus_Homo sapiens_hsa049401.99071358
17Cardiac muscle contraction_Homo sapiens_hsa042601.87020685
18Protein export_Homo sapiens_hsa030601.83312156
19Phototransduction_Homo sapiens_hsa047441.82837305
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74774770
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55258788
22Hematopoietic cell lineage_Homo sapiens_hsa046401.47423635
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46969993
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37208187
25Linoleic acid metabolism_Homo sapiens_hsa005911.34689828
26Rheumatoid arthritis_Homo sapiens_hsa053231.31002721
27RNA degradation_Homo sapiens_hsa030181.26212502
28Homologous recombination_Homo sapiens_hsa034401.25876408
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19872049
30Pyrimidine metabolism_Homo sapiens_hsa002401.19595562
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16338699
32Mismatch repair_Homo sapiens_hsa034301.13564846
33DNA replication_Homo sapiens_hsa030301.09880125
34Peroxisome_Homo sapiens_hsa041461.08970643
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07058123
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04326844
37Fanconi anemia pathway_Homo sapiens_hsa034601.02379436
38One carbon pool by folate_Homo sapiens_hsa006700.99062856
39Nitrogen metabolism_Homo sapiens_hsa009100.96522142
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95985873
41Caffeine metabolism_Homo sapiens_hsa002320.94258274
42T cell receptor signaling pathway_Homo sapiens_hsa046600.89910886
43Purine metabolism_Homo sapiens_hsa002300.89245405
44Nucleotide excision repair_Homo sapiens_hsa034200.87460673
45Butanoate metabolism_Homo sapiens_hsa006500.87028098
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86893784
47Propanoate metabolism_Homo sapiens_hsa006400.86256815
48Base excision repair_Homo sapiens_hsa034100.86105379
49Basal transcription factors_Homo sapiens_hsa030220.85607061
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83364768
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82630374
52Viral myocarditis_Homo sapiens_hsa054160.82475093
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82341063
54Tryptophan metabolism_Homo sapiens_hsa003800.81920337
55Systemic lupus erythematosus_Homo sapiens_hsa053220.79977715
56Olfactory transduction_Homo sapiens_hsa047400.78168714
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74207739
58Arachidonic acid metabolism_Homo sapiens_hsa005900.74104919
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70692467
60Spliceosome_Homo sapiens_hsa030400.69645986
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.66243539
62Retinol metabolism_Homo sapiens_hsa008300.64572593
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.61568477
64Chemical carcinogenesis_Homo sapiens_hsa052040.61208262
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59208893
66Metabolic pathways_Homo sapiens_hsa011000.57687693
67Staphylococcus aureus infection_Homo sapiens_hsa051500.55978701
68Sulfur relay system_Homo sapiens_hsa041220.54824905
69Sulfur metabolism_Homo sapiens_hsa009200.52192984
70Malaria_Homo sapiens_hsa051440.49064268
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.48111083
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46538368
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45035841
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44873715
75Regulation of autophagy_Homo sapiens_hsa041400.44533196
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.44488917
77Collecting duct acid secretion_Homo sapiens_hsa049660.43528391
78Ether lipid metabolism_Homo sapiens_hsa005650.43004838
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42297836
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.41658608
81RNA transport_Homo sapiens_hsa030130.39315615
82Measles_Homo sapiens_hsa051620.37606430
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.37545449
84Non-homologous end-joining_Homo sapiens_hsa034500.37032437
85Fat digestion and absorption_Homo sapiens_hsa049750.35449246
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35292520
87Nicotine addiction_Homo sapiens_hsa050330.32199514
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30536292
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30462412
90Herpes simplex infection_Homo sapiens_hsa051680.29838694
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26281968
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25654027
93Taste transduction_Homo sapiens_hsa047420.24975410
94beta-Alanine metabolism_Homo sapiens_hsa004100.23961651
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22891679
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22365541
97Fatty acid degradation_Homo sapiens_hsa000710.20439808
98Pyruvate metabolism_Homo sapiens_hsa006200.16928897
99Leishmaniasis_Homo sapiens_hsa051400.16220660
100Morphine addiction_Homo sapiens_hsa050320.15346702

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