ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.27304701
2	DNA deamination (GO:0045006)	6.62427123
3	ribosomal small subunit biogenesis (GO:0042274)	6.12723217
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.75203272
5	viral transcription (GO:0019083)	5.57800850
6	cytidine deamination (GO:0009972)	5.37125536
7	cytidine metabolic process (GO:0046087)	5.37125536
8	cytidine catabolic process (GO:0006216)	5.37125536
9	translational termination (GO:0006415)	5.32635698
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.01718646
11	ATP synthesis coupled proton transport (GO:0015986)	5.01718646
12	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.99010334
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.91296009
14	translational elongation (GO:0006414)	4.90025255
15	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.79291669
16	maturation of SSU-rRNA (GO:0030490)	4.74229412
17	cotranslational protein targeting to membrane (GO:0006613)	4.68392490
18	protein targeting to ER (GO:0045047)	4.65139981
19	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.54091197
20	protein localization to endoplasmic reticulum (GO:0070972)	4.43844817
21	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.43262450
22	respiratory electron transport chain (GO:0022904)	4.28210040
23	electron transport chain (GO:0022900)	4.23210725
24	ribosomal large subunit biogenesis (GO:0042273)	4.09118987
25	cellular protein complex disassembly (GO:0043624)	4.04797345
26	viral life cycle (GO:0019058)	3.99638114
27	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.96188995
28	ncRNA 3-end processing (GO:0043628)	3.87024931
29	protein complex biogenesis (GO:0070271)	3.86027007
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.81008409
31	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.66935984
32	translational initiation (GO:0006413)	3.64386416
33	base-excision repair, AP site formation (GO:0006285)	3.54160249
34	chaperone-mediated protein transport (GO:0072321)	3.54020117
35	protein neddylation (GO:0045116)	3.53778357
36	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.51240730
37	negative regulation of T cell apoptotic process (GO:0070233)	3.49993187
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.48285956
39	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.48285956
40	NADH dehydrogenase complex assembly (GO:0010257)	3.48285956
41	water-soluble vitamin biosynthetic process (GO:0042364)	3.47064712
42	deoxyribonucleotide catabolic process (GO:0009264)	3.46991144
43	purine deoxyribonucleotide catabolic process (GO:0009155)	3.45448398
44	mitochondrial respiratory chain complex assembly (GO:0033108)	3.42311423
45	regulation of regulatory T cell differentiation (GO:0045589)	3.41295323
46	translation (GO:0006412)	3.39798715
47	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.37907107
48	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.36691166
49	protein complex disassembly (GO:0043241)	3.30189490
50	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.28923149
51	sequestering of actin monomers (GO:0042989)	3.24756569
52	deoxyribose phosphate catabolic process (GO:0046386)	3.24610416
53	cellular component biogenesis (GO:0044085)	3.21024150
54	pyrimidine nucleotide catabolic process (GO:0006244)	3.19588234
55	macromolecular complex disassembly (GO:0032984)	3.12327666
56	ribonucleoprotein complex biogenesis (GO:0022613)	3.12130280
57	actin nucleation (GO:0045010)	3.11614022
58	positive T cell selection (GO:0043368)	3.08611163
59	platelet dense granule organization (GO:0060155)	3.07604527
60	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.03141138
61	positive thymic T cell selection (GO:0045059)	3.00408236
62	protein targeting to membrane (GO:0006612)	2.97285531
63	metallo-sulfur cluster assembly (GO:0031163)	2.97199372
64	iron-sulfur cluster assembly (GO:0016226)	2.97199372
65	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.93464201
66	termination of RNA polymerase III transcription (GO:0006386)	2.93464201
67	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.88465672
68	hydrogen ion transmembrane transport (GO:1902600)	2.87829152
69	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.85787428
70	ATP biosynthetic process (GO:0006754)	2.84946932
71	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.78132475
72	positive regulation of calcium-mediated signaling (GO:0050850)	2.77967640
73	purine nucleotide salvage (GO:0032261)	2.75571775
74	purine-containing compound salvage (GO:0043101)	2.74037461
75	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.72547763
76	regulation of cellular amino acid metabolic process (GO:0006521)	2.71672884
77	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.70347246
78	proton transport (GO:0015992)	2.69822367
79	mRNA catabolic process (GO:0006402)	2.69503134
80	pseudouridine synthesis (GO:0001522)	2.68699848
81	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.68071477
82	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.66549313
83	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.66375251
84	hydrogen transport (GO:0006818)	2.64747062
85	pyrimidine nucleoside catabolic process (GO:0046135)	2.62886532
86	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.61601344
87	regulation of T cell apoptotic process (GO:0070232)	2.60827821
88	positive regulation of defense response to virus by host (GO:0002230)	2.60408794
89	cytochrome complex assembly (GO:0017004)	2.59633998
90	2-deoxyribonucleotide metabolic process (GO:0009394)	2.57201077
91	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.56437691
92	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.56437691
93	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.56437691
94	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.56047114
95	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.56047114
96	negative T cell selection (GO:0043383)	2.55347911
97	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.54732775
98	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.54732775
99	behavioral response to nicotine (GO:0035095)	2.54664973
100	respiratory chain complex IV assembly (GO:0008535)	2.54019089

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.25011005
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.92705348
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.71907336
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.36606710
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.05318041
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.99622992
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.77235561
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.73571853
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.70349050
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.69128273
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.60903920
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.52111986
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.49734639
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.42011586
15	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.37345083
16	VDR_22108803_ChIP-Seq_LS180_Human	2.35883987
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.32581562
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.29720887
19	IGF1R_20145208_ChIP-Seq_DFB_Human	2.00696009
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.84779118
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.82032167
22	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.81392608
23	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.77855481
24	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.67265059
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.65230583
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.63476219
27	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.56511955
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.56180159
29	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.54622574
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54190740
31	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.52074349
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.49371945
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.47922657
34	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.47422938
35	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.46651946
36	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.45771710
37	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.44531586
38	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.42471532
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.40154613
40	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.39658388
41	AR_20517297_ChIP-Seq_VCAP_Human	1.34901715
42	NANOG_20526341_ChIP-Seq_ESCs_Human	1.34342455
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34177983
44	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.33242631
45	MYB_26560356_Chip-Seq_TH2_Human	1.33041382
46	EWS_26573619_Chip-Seq_HEK293_Human	1.32273185
47	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.32073094
48	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.31733923
49	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.31316892
50	TAF2_19829295_ChIP-Seq_ESCs_Human	1.31159116
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26643977
52	NCOR_22424771_ChIP-Seq_293T_Human	1.25626944
53	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.25567936
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25166094
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25166094
56	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.24690244
57	GATA3_26560356_Chip-Seq_TH2_Human	1.24670678
58	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22867668
59	BCL6_27268052_Chip-Seq_Bcells_Human	1.22015794
60	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20621998
61	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19381883
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14784664
63	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.13667741
64	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.12808835
65	ERA_21632823_ChIP-Seq_H3396_Human	1.11274529
66	P300_27268052_Chip-Seq_Bcells_Human	1.10304130
67	GATA3_27048872_Chip-Seq_THYMUS_Human	1.08779910
68	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08117468
69	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.07370512
70	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.06748746
71	CIITA_25753668_ChIP-Seq_RAJI_Human	1.06295347
72	HTT_18923047_ChIP-ChIP_STHdh_Human	1.05412652
73	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.04524907
74	GABP_19822575_ChIP-Seq_HepG2_Human	1.04489325
75	FUS_26573619_Chip-Seq_HEK293_Human	1.03263158
76	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.03028090
77	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02815109
78	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.02307036
79	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.01838763
80	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.01627801
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00873377
82	TTF2_22483619_ChIP-Seq_HELA_Human	0.98907060
83	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.98900232
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98609329
85	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.98503140
86	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.98366233
87	CTCF_20526341_ChIP-Seq_ESCs_Human	0.98363964
88	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98136286
89	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97229553
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97229553
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96573359
92	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.95868571
93	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95491343
94	XRN2_22483619_ChIP-Seq_HELA_Human	0.94661132
95	E2F1_20622854_ChIP-Seq_HELA_Human	0.93697711
96	STAT1_20625510_ChIP-Seq_HELA_Human	0.93575835
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92785212
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.91637948
99	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.91283925
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.91245065

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.59896988
2	MP0009379_abnormal_foot_pigmentation	4.52212460
3	MP0001835_abnormal_antigen_presentation	2.92567544
4	MP0006292_abnormal_olfactory_placode	2.77886499
5	MP0009785_altered_susceptibility_to	2.46924835
6	MP0001873_stomach_inflammation	2.29224216
7	MP0005646_abnormal_pituitary_gland	2.11781833
8	MP0003646_muscle_fatigue	2.06739144
9	MP0005645_abnormal_hypothalamus_physiol	1.97484968
10	MP0002163_abnormal_gland_morphology	1.97013332
11	MP0002148_abnormal_hypersensitivity_rea	1.86839731
12	MP0003763_abnormal_thymus_physiology	1.79462103
13	MP0001800_abnormal_humoral_immune	1.75365288
14	MP0002102_abnormal_ear_morphology	1.73663198
15	MP0002876_abnormal_thyroid_physiology	1.71396837
16	MP0004147_increased_porphyrin_level	1.69828583
17	MP0006072_abnormal_retinal_apoptosis	1.68584669
18	MP0008872_abnormal_physiological_respon	1.66550794
19	MP0008875_abnormal_xenobiotic_pharmacok	1.66235840
20	MP0006082_CNS_inflammation	1.65455909
21	MP0005000_abnormal_immune_tolerance	1.63499670
22	MP0000685_abnormal_immune_system	1.63305190
23	MP0000372_irregular_coat_pigmentation	1.63029363
24	MP0009333_abnormal_splenocyte_physiolog	1.60570434
25	MP0002160_abnormal_reproductive_system	1.57370132
26	MP0002138_abnormal_hepatobiliary_system	1.56797007
27	MP0005551_abnormal_eye_electrophysiolog	1.55160130
28	MP0001968_abnormal_touch/_nociception	1.53706763
29	MP0002837_dystrophic_cardiac_calcinosis	1.50654070
30	MP0008058_abnormal_DNA_repair	1.50274278
31	MP0001905_abnormal_dopamine_level	1.50212623
32	MP0002420_abnormal_adaptive_immunity	1.49439096
33	MP0002723_abnormal_immune_serum	1.48438897
34	MP0001819_abnormal_immune_cell	1.46372516
35	MP0005389_reproductive_system_phenotype	1.44038947
36	MP0002736_abnormal_nociception_after	1.43337500
37	MP0003866_abnormal_defecation	1.40349659
38	MP0008789_abnormal_olfactory_epithelium	1.40325235
39	MP0002234_abnormal_pharynx_morphology	1.39064157
40	MP0002166_altered_tumor_susceptibility	1.38350594
41	MP0008877_abnormal_DNA_methylation	1.38028930
42	MP0005025_abnormal_response_to	1.37912880
43	MP0003878_abnormal_ear_physiology	1.37384159
44	MP0005377_hearing/vestibular/ear_phenot	1.37384159
45	MP0005387_immune_system_phenotype	1.37024345
46	MP0001790_abnormal_immune_system	1.37024345
47	MP0002095_abnormal_skin_pigmentation	1.35487182
48	MP0004885_abnormal_endolymph	1.35323169
49	MP0005084_abnormal_gallbladder_morpholo	1.34267242
50	MP0005075_abnormal_melanosome_morpholog	1.32393879
51	MP0002452_abnormal_antigen_presenting	1.28832077
52	MP0002277_abnormal_respiratory_mucosa	1.27706158
53	MP0004145_abnormal_muscle_electrophysio	1.27675264
54	MP0001986_abnormal_taste_sensitivity	1.26929887
55	MP0002006_tumorigenesis	1.24848007
56	MP0006276_abnormal_autonomic_nervous	1.23858826
57	MP0001919_abnormal_reproductive_system	1.22168608
58	MP0005379_endocrine/exocrine_gland_phen	1.19541520
59	MP0004142_abnormal_muscle_tone	1.16997866
60	MP0000716_abnormal_immune_system	1.16707067
61	MP0002398_abnormal_bone_marrow	1.14363441
62	MP0002933_joint_inflammation	1.13991188
63	MP0003786_premature_aging	1.12805193
64	MP0003787_abnormal_imprinting	1.10055474
65	MP0003806_abnormal_nucleotide_metabolis	1.08747553
66	MP0002405_respiratory_system_inflammati	1.06190741
67	MP0000689_abnormal_spleen_morphology	1.06150361
68	MP0006036_abnormal_mitochondrial_physio	1.02970599
69	MP0002653_abnormal_ependyma_morphology	0.99667996
70	MP0000703_abnormal_thymus_morphology	0.99636207
71	MP0008995_early_reproductive_senescence	0.99227311
72	MP0009764_decreased_sensitivity_to	0.95250570
73	MP0005410_abnormal_fertilization	0.94383410
74	MP0000631_abnormal_neuroendocrine_gland	0.93056759
75	MP0002722_abnormal_immune_system	0.92897941
76	MP0010155_abnormal_intestine_physiology	0.91766234
77	MP0005253_abnormal_eye_physiology	0.89254055
78	MP0001764_abnormal_homeostasis	0.89033637
79	MP0002429_abnormal_blood_cell	0.88773086
80	MP0003011_delayed_dark_adaptation	0.87607123
81	MP0002272_abnormal_nervous_system	0.86001454
82	MP0005636_abnormal_mineral_homeostasis	0.85548532
83	MP0001485_abnormal_pinna_reflex	0.83867198
84	MP0002733_abnormal_thermal_nociception	0.83543040
85	MP0001663_abnormal_digestive_system	0.82099986
86	MP0001845_abnormal_inflammatory_respons	0.80963901
87	MP0001970_abnormal_pain_threshold	0.80302692
88	MP0002693_abnormal_pancreas_physiology	0.79808095
89	MP0003252_abnormal_bile_duct	0.78442988
90	MP0003879_abnormal_hair_cell	0.78193821
91	MP0002132_abnormal_respiratory_system	0.77678203
92	MP0005499_abnormal_olfactory_system	0.77583689
93	MP0005394_taste/olfaction_phenotype	0.77583689
94	MP0003121_genomic_imprinting	0.77006224
95	MP0005174_abnormal_tail_pigmentation	0.73839685
96	MP0002822_catalepsy	0.73198849
97	MP0001765_abnormal_ion_homeostasis	0.72534596
98	MP0001293_anophthalmia	0.72337222
99	MP0005085_abnormal_gallbladder_physiolo	0.71105858
100	MP0002419_abnormal_innate_immunity	0.70463983

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.81814257
2	Mitochondrial inheritance (HP:0001427)	4.50107901
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.46324370
4	3-Methylglutaconic aciduria (HP:0003535)	4.08874858
5	Acute encephalopathy (HP:0006846)	4.01113500
6	Progressive macrocephaly (HP:0004481)	3.98777126
7	Increased hepatocellular lipid droplets (HP:0006565)	3.94796127
8	Increased CSF lactate (HP:0002490)	3.88133967
9	Elevated erythrocyte sedimentation rate (HP:0003565)	3.87250504
10	Aplastic anemia (HP:0001915)	3.83615018
11	Congenital stationary night blindness (HP:0007642)	3.59954617
12	Hepatocellular necrosis (HP:0001404)	3.58490101
13	Increased intramyocellular lipid droplets (HP:0012240)	3.55010819
14	Lipid accumulation in hepatocytes (HP:0006561)	3.50098733
15	Renal Fanconi syndrome (HP:0001994)	3.43880656
16	Severe combined immunodeficiency (HP:0004430)	3.38145064
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.24361004
18	Constricted visual fields (HP:0001133)	3.21995318
19	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.20162158
20	Hepatic necrosis (HP:0002605)	3.17620362
21	Cerebral edema (HP:0002181)	3.16791948
22	Reticulocytopenia (HP:0001896)	3.09486539
23	Attenuation of retinal blood vessels (HP:0007843)	3.04573487
24	Optic disc pallor (HP:0000543)	3.04112156
25	Abnormality of B cell number (HP:0010975)	3.04054690
26	Abnormality of cells of the erythroid lineage (HP:0012130)	2.97354842
27	Increased muscle lipid content (HP:0009058)	2.88606715
28	Hypoproteinemia (HP:0003075)	2.86148485
29	Autoimmune hemolytic anemia (HP:0001890)	2.81761158
30	IgG deficiency (HP:0004315)	2.73741458
31	Abnormality of midbrain morphology (HP:0002418)	2.71583514
32	Molar tooth sign on MRI (HP:0002419)	2.71583514
33	Pancreatic cysts (HP:0001737)	2.67469903
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.67295726
35	B lymphocytopenia (HP:0010976)	2.65700830
36	Abnormal number of erythroid precursors (HP:0012131)	2.65502132
37	Macrocytic anemia (HP:0001972)	2.63666749
38	Methylmalonic acidemia (HP:0002912)	2.61488158
39	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.61118978
40	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.61118978
41	Thyroiditis (HP:0100646)	2.58615388
42	Exertional dyspnea (HP:0002875)	2.54194729
43	Increased serum lactate (HP:0002151)	2.51867853
44	Lactic acidosis (HP:0003128)	2.49139885
45	Combined immunodeficiency (HP:0005387)	2.47086202
46	Abnormality of T cell number (HP:0011839)	2.44936278
47	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.43530130
48	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.37724813
49	T lymphocytopenia (HP:0005403)	2.34248667
50	Abolished electroretinogram (ERG) (HP:0000550)	2.33438558
51	Abnormality of the prostate (HP:0008775)	2.33412702
52	Congenital, generalized hypertrichosis (HP:0004540)	2.26823178
53	Pancreatic fibrosis (HP:0100732)	2.26389661
54	Absent/shortened dynein arms (HP:0200106)	2.26238733
55	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.26238733
56	Type I transferrin isoform profile (HP:0003642)	2.20706159
57	Hyperglycinemia (HP:0002154)	2.20258339
58	True hermaphroditism (HP:0010459)	2.20001552
59	Lethargy (HP:0001254)	2.17542663
60	Abnormality of eosinophils (HP:0001879)	2.17482267
61	Abnormality of macular pigmentation (HP:0008002)	2.16225973
62	Abnormal respiratory motile cilium morphology (HP:0005938)	2.15162962
63	Abnormal respiratory epithelium morphology (HP:0012253)	2.15162962
64	Eosinophilia (HP:0001880)	2.14041864
65	Exercise intolerance (HP:0003546)	2.13664786
66	Colon cancer (HP:0003003)	2.13324792
67	Respiratory failure (HP:0002878)	2.13003607
68	Pallor (HP:0000980)	2.11809661
69	Panhypogammaglobulinemia (HP:0003139)	2.11634522
70	Abnormality of renal resorption (HP:0011038)	2.10564526
71	Pancytopenia (HP:0001876)	2.09612501
72	Autoimmune thrombocytopenia (HP:0001973)	2.08945457
73	Abnormality of T cells (HP:0002843)	2.05666788
74	Abnormal protein glycosylation (HP:0012346)	2.03781603
75	Abnormal glycosylation (HP:0012345)	2.03781603
76	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.03781603
77	Abnormal protein N-linked glycosylation (HP:0012347)	2.03781603
78	Methylmalonic aciduria (HP:0012120)	1.99710378
79	Leukodystrophy (HP:0002415)	1.95773017
80	Stomatitis (HP:0010280)	1.94676694
81	Abnormal respiratory motile cilium physiology (HP:0012261)	1.93612650
82	Respiratory difficulties (HP:0002880)	1.92642362
83	Increased IgM level (HP:0003496)	1.91873027
84	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.90762676
85	Type 2 muscle fiber atrophy (HP:0003554)	1.90565320
86	Abnormality of urine glucose concentration (HP:0011016)	1.90421432
87	Glycosuria (HP:0003076)	1.90421432
88	Absent thumb (HP:0009777)	1.88406780
89	Asplenia (HP:0001746)	1.84227477
90	Hyperphosphaturia (HP:0003109)	1.83786531
91	Type II lissencephaly (HP:0007260)	1.83610315
92	Pendular nystagmus (HP:0012043)	1.82931682
93	Ketosis (HP:0001946)	1.82904077
94	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.82873809
95	Cerebral palsy (HP:0100021)	1.80556396
96	Abnormal ciliary motility (HP:0012262)	1.79310908
97	Decreased central vision (HP:0007663)	1.76554229
98	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.73936044
99	Emotional lability (HP:0000712)	1.71774406
100	Prostate neoplasm (HP:0100787)	1.71368117

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	KDR	4.02577040
2	TESK2	3.85311093
3	TXK	3.64289377
4	BCKDK	3.60263623
5	MAP4K2	3.04289777
6	ZAK	2.85134247
7	VRK2	2.82547423
8	KIT	2.34273950
9	TLK1	2.28969295
10	STK16	2.26726953
11	TAOK3	2.26451776
12	ADRBK2	2.12421777
13	MAP4K1	2.10529899
14	GRK1	2.03860630
15	FES	2.03184509
16	TEC	1.94581688
17	MAP3K12	1.89666952
18	SCYL2	1.87587570
19	CDK19	1.86550055
20	LIMK1	1.80009948
21	VRK1	1.70914967
22	PINK1	1.59153104
23	TIE1	1.57327466
24	ITK	1.51802022
25	NUAK1	1.43701184
26	WNK4	1.41386044
27	SYK	1.38056807
28	FRK	1.36807698
29	PASK	1.35793740
30	NME2	1.34382011
31	CAMKK2	1.14580031
32	PRKCQ	1.11910771
33	IKBKB	1.11874185
34	MUSK	1.11786429
35	TESK1	1.08791437
36	BTK	1.06079701
37	MAP3K11	1.00595303
38	LCK	0.97877146
39	PIM2	0.90926617
40	DYRK2	0.79959641
41	BUB1	0.78780508
42	MAPKAPK3	0.78678547
43	RPS6KA5	0.77999441
44	LYN	0.76486201
45	CSK	0.75251924
46	TNK2	0.75222053
47	DAPK1	0.73825479
48	CAMKK1	0.71139933
49	INSRR	0.69904863
50	PIK3CA	0.69652473
51	ADRBK1	0.69321574
52	GRK6	0.68891891
53	MAP2K7	0.67508373
54	EIF2AK3	0.66806033
55	PIK3CG	0.66478620
56	MAPKAPK5	0.66092431
57	AURKA	0.65905377
58	GRK7	0.64317916
59	MST4	0.61493123
60	MYLK	0.61236451
61	CSF1R	0.60698470
62	WNK3	0.60583552
63	OBSCN	0.59017210
64	PLK4	0.58155527
65	TAF1	0.54942706
66	NME1	0.54499191
67	IKBKE	0.52521247
68	DAPK3	0.51798714
69	CSNK1G3	0.51690704
70	OXSR1	0.51229571
71	LRRK2	0.49803230
72	PIM1	0.49252328
73	ABL2	0.47595393
74	TYRO3	0.46515044
75	PRKACA	0.46207793
76	BMPR1B	0.43063137
77	MAPK13	0.42751999
78	PRKCA	0.41958537
79	CSNK2A2	0.41706801
80	CSNK2A1	0.41690130
81	STK39	0.40842265
82	MAP2K6	0.40811515
83	MAP3K5	0.39514058
84	RPS6KB2	0.38915723
85	CSNK1G2	0.38164565
86	PRKCI	0.36115771
87	MATK	0.36064086
88	IGF1R	0.34865005
89	GRK5	0.34554192
90	INSR	0.32567253
91	DAPK2	0.32373480
92	CSNK1A1	0.32353394
93	PRKCG	0.31807658
94	RPS6KA4	0.31649791
95	ZAP70	0.31647576
96	CSNK1G1	0.30966840
97	CAMK1	0.30086175
98	CSNK1A1L	0.29354398
99	AURKB	0.29028422
100	EIF2AK1	0.28823772

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.83024386
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.22808289
3	Proteasome_Homo sapiens_hsa03050	3.66566396
4	Parkinsons disease_Homo sapiens_hsa05012	3.40075592
5	Primary immunodeficiency_Homo sapiens_hsa05340	3.32286597
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.62399361
7	Allograft rejection_Homo sapiens_hsa05330	2.40723664
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.37135646
9	Alzheimers disease_Homo sapiens_hsa05010	2.34430287
10	Asthma_Homo sapiens_hsa05310	2.31856627
11	Huntingtons disease_Homo sapiens_hsa05016	2.23029132
12	RNA polymerase_Homo sapiens_hsa03020	2.18470279
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.16266442
14	Antigen processing and presentation_Homo sapiens_hsa04612	2.01969142
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.99955149
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.99071358
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.87020685
18	Protein export_Homo sapiens_hsa03060	1.83312156
19	Phototransduction_Homo sapiens_hsa04744	1.82837305
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.74774770
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.55258788
22	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.47423635
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.46969993
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37208187
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34689828
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.31002721
27	RNA degradation_Homo sapiens_hsa03018	1.26212502
28	Homologous recombination_Homo sapiens_hsa03440	1.25876408
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19872049
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19595562
31	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.16338699
32	Mismatch repair_Homo sapiens_hsa03430	1.13564846
33	DNA replication_Homo sapiens_hsa03030	1.09880125
34	Peroxisome_Homo sapiens_hsa04146	1.08970643
35	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.07058123
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04326844
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02379436
38	One carbon pool by folate_Homo sapiens_hsa00670	0.99062856
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.96522142
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.95985873
41	Caffeine metabolism_Homo sapiens_hsa00232	0.94258274
42	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.89910886
43	Purine metabolism_Homo sapiens_hsa00230	0.89245405
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.87460673
45	Butanoate metabolism_Homo sapiens_hsa00650	0.87028098
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86893784
47	Propanoate metabolism_Homo sapiens_hsa00640	0.86256815
48	Base excision repair_Homo sapiens_hsa03410	0.86105379
49	Basal transcription factors_Homo sapiens_hsa03022	0.85607061
50	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83364768
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.82630374
52	Viral myocarditis_Homo sapiens_hsa05416	0.82475093
53	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.82341063
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.81920337
55	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.79977715
56	Olfactory transduction_Homo sapiens_hsa04740	0.78168714
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74207739
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74104919
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70692467
60	Spliceosome_Homo sapiens_hsa03040	0.69645986
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66243539
62	Retinol metabolism_Homo sapiens_hsa00830	0.64572593
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61568477
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61208262
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59208893
66	Metabolic pathways_Homo sapiens_hsa01100	0.57687693
67	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.55978701
68	Sulfur relay system_Homo sapiens_hsa04122	0.54824905
69	Sulfur metabolism_Homo sapiens_hsa00920	0.52192984
70	Malaria_Homo sapiens_hsa05144	0.49064268
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48111083
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46538368
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45035841
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44873715
75	Regulation of autophagy_Homo sapiens_hsa04140	0.44533196
76	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.44488917
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43528391
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.43004838
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.42297836
80	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.41658608
81	RNA transport_Homo sapiens_hsa03013	0.39315615
82	Measles_Homo sapiens_hsa05162	0.37606430
83	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37545449
84	Non-homologous end-joining_Homo sapiens_hsa03450	0.37032437
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.35449246
86	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35292520
87	Nicotine addiction_Homo sapiens_hsa05033	0.32199514
88	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.30536292
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.30462412
90	Herpes simplex infection_Homo sapiens_hsa05168	0.29838694
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.26281968
92	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.25654027
93	Taste transduction_Homo sapiens_hsa04742	0.24975410
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.23961651
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.22891679
96	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.22365541
97	Fatty acid degradation_Homo sapiens_hsa00071	0.20439808
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.16928897
99	Leishmaniasis_Homo sapiens_hsa05140	0.16220660
100	Morphine addiction_Homo sapiens_hsa05032	0.15346702

RPL10AP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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