ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	9.51146010
2	ribosomal small subunit biogenesis (GO:0042274)	8.55450152
3	ribosomal small subunit assembly (GO:0000028)	8.37474868
4	viral transcription (GO:0019083)	8.24090826
5	translational termination (GO:0006415)	7.96902219
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.71681300
7	cotranslational protein targeting to membrane (GO:0006613)	6.61366714
8	translational elongation (GO:0006414)	6.57598344
9	protein targeting to ER (GO:0045047)	6.56332877
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.29518151
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.19289232
12	ATP synthesis coupled proton transport (GO:0015986)	6.19289232
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.19009687
14	protein localization to endoplasmic reticulum (GO:0070972)	6.15758370
15	viral life cycle (GO:0019058)	6.12340283
16	cellular protein complex disassembly (GO:0043624)	5.96932056
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.85020683
18	chaperone-mediated protein transport (GO:0072321)	5.60972553
19	translational initiation (GO:0006413)	5.32233594
20	protein complex disassembly (GO:0043241)	5.00761893
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.92349820
22	ribosomal large subunit biogenesis (GO:0042273)	4.91199495
23	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.81136708
24	macromolecular complex disassembly (GO:0032984)	4.79817162
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.64248061
26	NADH dehydrogenase complex assembly (GO:0010257)	4.64248061
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.64248061
28	protein neddylation (GO:0045116)	4.48980725
29	protein complex biogenesis (GO:0070271)	4.47004203
30	respiratory electron transport chain (GO:0022904)	4.46559597
31	translation (GO:0006412)	4.41023922
32	electron transport chain (GO:0022900)	4.36079345
33	protein targeting to membrane (GO:0006612)	4.34246926
34	proline biosynthetic process (GO:0006561)	4.22267667
35	ribonucleoprotein complex biogenesis (GO:0022613)	4.12940729
36	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.12127720
37	cellular component biogenesis (GO:0044085)	4.09413960
38	mitochondrial respiratory chain complex assembly (GO:0033108)	4.06349606
39	mRNA catabolic process (GO:0006402)	3.91948720
40	RNA catabolic process (GO:0006401)	3.57306319
41	behavioral response to nicotine (GO:0035095)	3.52940254
42	ATP biosynthetic process (GO:0006754)	3.43734667
43	kynurenine metabolic process (GO:0070189)	3.39245602
44	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.38121878
45	DNA damage response, detection of DNA damage (GO:0042769)	3.35285182
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.34867759
47	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.33599824
48	DNA deamination (GO:0045006)	3.25086546
49	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.22244413
50	platelet dense granule organization (GO:0060155)	3.22076730
51	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.20158330
52	rRNA metabolic process (GO:0016072)	3.18935843
53	rRNA processing (GO:0006364)	3.17522641
54	hydrogen ion transmembrane transport (GO:1902600)	3.15440283
55	protein targeting (GO:0006605)	3.11329049
56	water-soluble vitamin biosynthetic process (GO:0042364)	3.08525603
57	protein-cofactor linkage (GO:0018065)	3.05526361
58	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.98471115
59	rRNA catabolic process (GO:0016075)	2.96075888
60	neuronal action potential propagation (GO:0019227)	2.95246509
61	spliceosomal complex assembly (GO:0000245)	2.95199537
62	regulation of cilium movement (GO:0003352)	2.93438264
63	establishment of protein localization to membrane (GO:0090150)	2.92893134
64	establishment of protein localization to organelle (GO:0072594)	2.92179232
65	protein targeting to mitochondrion (GO:0006626)	2.90993629
66	proton transport (GO:0015992)	2.88306247
67	intracellular protein transmembrane import (GO:0044743)	2.86713657
68	hydrogen transport (GO:0006818)	2.83342128
69	mannosylation (GO:0097502)	2.82333422
70	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.76127058
71	positive regulation of immune response to tumor cell (GO:0002839)	2.73816637
72	regulation of immune response to tumor cell (GO:0002837)	2.73816637
73	regulation of response to tumor cell (GO:0002834)	2.73816637
74	positive regulation of response to tumor cell (GO:0002836)	2.73816637
75	establishment of protein localization to mitochondrion (GO:0072655)	2.70773873
76	protein K6-linked ubiquitination (GO:0085020)	2.69233079
77	axoneme assembly (GO:0035082)	2.68315702
78	nonmotile primary cilium assembly (GO:0035058)	2.67891517
79	indole-containing compound catabolic process (GO:0042436)	2.67807808
80	indolalkylamine catabolic process (GO:0046218)	2.67807808
81	tryptophan catabolic process (GO:0006569)	2.67807808
82	proline metabolic process (GO:0006560)	2.66994876
83	peptidyl-histidine modification (GO:0018202)	2.64006787
84	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.61578139
85	chromatin remodeling at centromere (GO:0031055)	2.60753046
86	protein localization to mitochondrion (GO:0070585)	2.60233550
87	proteasome assembly (GO:0043248)	2.58901166
88	ncRNA 3-end processing (GO:0043628)	2.58135808
89	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.58107075
90	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.56672930
91	positive regulation of muscle cell apoptotic process (GO:0010661)	2.56397777
92	transmission of nerve impulse (GO:0019226)	2.56305686
93	replication fork processing (GO:0031297)	2.55826955
94	regulation of mitochondrial translation (GO:0070129)	2.55093577
95	GTP biosynthetic process (GO:0006183)	2.54191942
96	positive regulation of respiratory burst (GO:0060267)	2.53895158
97	nucleoside triphosphate biosynthetic process (GO:0009142)	2.52378170
98	multicellular organism reproduction (GO:0032504)	2.51504529
99	termination of RNA polymerase III transcription (GO:0006386)	2.51327955
100	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.51327955

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.19125192
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.77993572
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.34858087
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.98580783
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.91848509
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.86143841
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.30863877
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.15832549
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.12124830
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.00511531
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.99013824
12	VDR_22108803_ChIP-Seq_LS180_Human	2.90936474
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.36065205
14	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.17233368
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.10684923
16	TTF2_22483619_ChIP-Seq_HELA_Human	2.03561459
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.01254206
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.97526523
19	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.94882197
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.94249291
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.92658924
22	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.89684084
23	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.83604712
24	XRN2_22483619_ChIP-Seq_HELA_Human	1.83341791
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.81509143
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.79472310
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.76511584
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.75478567
29	ZNF274_21170338_ChIP-Seq_K562_Hela	1.71649844
30	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.70621515
31	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.67221172
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.64590801
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.58431634
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54422099
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.46855213
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.45591394
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41457782
38	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.40400218
39	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.39946656
40	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.38299569
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.35142797
42	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.34889807
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.33095014
44	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.26954021
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.25495847
46	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.25486471
47	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.22652111
48	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.22590399
49	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.17570570
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16989056
51	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.15969618
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.15898818
53	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.14128369
54	GATA1_22025678_ChIP-Seq_K562_Human	1.12988653
55	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.11822252
56	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11565770
57	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.11013007
58	EWS_26573619_Chip-Seq_HEK293_Human	1.09025916
59	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.07822448
60	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.07381045
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03618111
62	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99558605
63	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.99177948
64	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98216774
65	NCOR_22424771_ChIP-Seq_293T_Human	0.97624414
66	DCP1A_22483619_ChIP-Seq_HELA_Human	0.96988994
67	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.96051508
68	FUS_26573619_Chip-Seq_HEK293_Human	0.95703919
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.94776495
70	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.92591235
71	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.92558060
72	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.91863411
73	RNF2_27304074_Chip-Seq_NSC_Mouse	0.91118899
74	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90664858
75	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.90309454
76	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.90141377
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.89836256
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.88848370
79	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.88848370
80	ERA_21632823_ChIP-Seq_H3396_Human	0.88830168
81	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.87899518
82	REST_21632747_ChIP-Seq_MESCs_Mouse	0.87565125
83	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.86352654
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.85035204
85	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.84385268
86	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.83500210
87	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.83148876
88	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.82286527
89	AR_20517297_ChIP-Seq_VCAP_Human	0.82026814
90	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.81848021
91	CTCF_20526341_ChIP-Seq_ESCs_Human	0.80888485
92	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.79760874
93	P53_21459846_ChIP-Seq_SAOS-2_Human	0.79387058
94	KDM5A_27292631_Chip-Seq_BREAST_Human	0.79039784
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.78547169
96	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.78064751
97	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.77854241
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.77584616
99	E2F1_20622854_ChIP-Seq_HELA_Human	0.76860268
100	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.76130222

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.28064778
2	MP0004147_increased_porphyrin_level	4.12119132
3	MP0005377_hearing/vestibular/ear_phenot	3.57345211
4	MP0003878_abnormal_ear_physiology	3.57345211
5	MP0006292_abnormal_olfactory_placode	3.41833464
6	MP0003787_abnormal_imprinting	2.86455172
7	MP0002277_abnormal_respiratory_mucosa	2.59248316
8	MP0004145_abnormal_muscle_electrophysio	2.45183793
9	MP0008877_abnormal_DNA_methylation	2.35179469
10	MP0008789_abnormal_olfactory_epithelium	2.11760042
11	MP0002160_abnormal_reproductive_system	2.11295062
12	MP0005394_taste/olfaction_phenotype	1.97509381
13	MP0005499_abnormal_olfactory_system	1.97509381
14	MP0002876_abnormal_thyroid_physiology	1.94025155
15	MP0004142_abnormal_muscle_tone	1.92117665
16	MP0002163_abnormal_gland_morphology	1.88634801
17	MP0001485_abnormal_pinna_reflex	1.87243355
18	MP0004885_abnormal_endolymph	1.84094060
19	MP0008872_abnormal_physiological_respon	1.80486902
20	MP0001188_hyperpigmentation	1.72925498
21	MP0003123_paternal_imprinting	1.70859598
22	MP0005551_abnormal_eye_electrophysiolog	1.69212918
23	MP0005389_reproductive_system_phenotype	1.68450986
24	MP0003121_genomic_imprinting	1.68354909
25	MP0002736_abnormal_nociception_after	1.66069544
26	MP0001968_abnormal_touch/_nociception	1.63615092
27	MP0005646_abnormal_pituitary_gland	1.62674738
28	MP0006072_abnormal_retinal_apoptosis	1.61816837
29	MP0003195_calcinosis	1.61506731
30	MP0003315_abnormal_perineum_morphology	1.59382877
31	MP0003567_abnormal_fetal_cardiomyocyte	1.57438331
32	MP0006276_abnormal_autonomic_nervous	1.49647804
33	MP0005084_abnormal_gallbladder_morpholo	1.47227127
34	MP0002837_dystrophic_cardiac_calcinosis	1.45191410
35	MP0008875_abnormal_xenobiotic_pharmacok	1.42922593
36	MP0003136_yellow_coat_color	1.41861915
37	MP0003186_abnormal_redox_activity	1.41043236
38	MP0002638_abnormal_pupillary_reflex	1.38888590
39	MP0002272_abnormal_nervous_system	1.38808952
40	MP0002095_abnormal_skin_pigmentation	1.37325303
41	MP0003880_abnormal_central_pattern	1.37318746
42	MP0001293_anophthalmia	1.36402351
43	MP0000631_abnormal_neuroendocrine_gland	1.30708145
44	MP0000049_abnormal_middle_ear	1.30306910
45	MP0002938_white_spotting	1.28926604
46	MP0003693_abnormal_embryo_hatching	1.27499658
47	MP0001919_abnormal_reproductive_system	1.26218107
48	MP0001986_abnormal_taste_sensitivity	1.25054552
49	MP0002138_abnormal_hepatobiliary_system	1.24595621
50	MP0004133_heterotaxia	1.23345258
51	MP0003122_maternal_imprinting	1.19591289
52	MP0002102_abnormal_ear_morphology	1.16686422
53	MP0003011_delayed_dark_adaptation	1.15247345
54	MP0002234_abnormal_pharynx_morphology	1.11811408
55	MP0002653_abnormal_ependyma_morphology	1.11313985
56	MP0000778_abnormal_nervous_system	1.03894528
57	MP0005257_abnormal_intraocular_pressure	1.01748630
58	MP0002210_abnormal_sex_determination	0.99766073
59	MP0009745_abnormal_behavioral_response	0.98653456
60	MP0005195_abnormal_posterior_eye	0.95939705
61	MP0005379_endocrine/exocrine_gland_phen	0.95801974
62	MP0008058_abnormal_DNA_repair	0.91591664
63	MP0001529_abnormal_vocalization	0.91246882
64	MP0002184_abnormal_innervation	0.90388205
65	MP0005645_abnormal_hypothalamus_physiol	0.89509394
66	MP0003646_muscle_fatigue	0.88867853
67	MP0001984_abnormal_olfaction	0.87292468
68	MP0002557_abnormal_social/conspecific_i	0.87235281
69	MP0005174_abnormal_tail_pigmentation	0.86929875
70	MP0003718_maternal_effect	0.86552154
71	MP0002733_abnormal_thermal_nociception	0.85613568
72	MP0008775_abnormal_heart_ventricle	0.84906403
73	MP0001286_abnormal_eye_development	0.84273441
74	MP0001765_abnormal_ion_homeostasis	0.83878124
75	MP0002752_abnormal_somatic_nervous	0.83736260
76	MP0001905_abnormal_dopamine_level	0.82849182
77	MP0009765_abnormal_xenobiotic_induced	0.82217557
78	MP0000026_abnormal_inner_ear	0.82179625
79	MP0003938_abnormal_ear_development	0.81428365
80	MP0005253_abnormal_eye_physiology	0.81088815
81	MP0002572_abnormal_emotion/affect_behav	0.80379296
82	MP0005671_abnormal_response_to	0.80206330
83	MP0005083_abnormal_biliary_tract	0.80075225
84	MP0001970_abnormal_pain_threshold	0.79970667
85	MP0002233_abnormal_nose_morphology	0.79759951
86	MP0001663_abnormal_digestive_system	0.78380297
87	MP0001963_abnormal_hearing_physiology	0.76691994
88	MP0001764_abnormal_homeostasis	0.75755720
89	MP0001145_abnormal_male_reproductive	0.75526607
90	MP0001119_abnormal_female_reproductive	0.75436379
91	MP0000427_abnormal_hair_cycle	0.73706528
92	MP0001542_abnormal_bone_strength	0.72227944
93	MP0003635_abnormal_synaptic_transmissio	0.71607818
94	MP0004742_abnormal_vestibular_system	0.69985457
95	MP0005636_abnormal_mineral_homeostasis	0.69948123
96	MP0001486_abnormal_startle_reflex	0.69576818
97	MP0001324_abnormal_eye_pigmentation	0.68433969
98	MP0002067_abnormal_sensory_capabilities	0.67907648
99	MP0001727_abnormal_embryo_implantation	0.66421636
100	MP0002063_abnormal_learning/memory/cond	0.66178486

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.35520505
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.49847514
3	Acute necrotizing encephalopathy (HP:0006965)	4.63566658
4	Macrocytic anemia (HP:0001972)	4.38745123
5	Abnormal number of erythroid precursors (HP:0012131)	4.22299714
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.18319634
7	Abnormal mitochondria in muscle tissue (HP:0008316)	4.12421830
8	Mitochondrial inheritance (HP:0001427)	4.12010621
9	Abnormal rod and cone electroretinograms (HP:0008323)	4.06769010
10	Congenital stationary night blindness (HP:0007642)	3.96108654
11	Acute encephalopathy (HP:0006846)	3.92894652
12	Septo-optic dysplasia (HP:0100842)	3.85777679
13	Increased CSF lactate (HP:0002490)	3.67378396
14	Progressive macrocephaly (HP:0004481)	3.66020626
15	Hepatocellular necrosis (HP:0001404)	3.43782298
16	Pallor (HP:0000980)	3.41349937
17	Hepatic necrosis (HP:0002605)	3.28908575
18	Increased hepatocellular lipid droplets (HP:0006565)	3.09459133
19	Hyperglycinemia (HP:0002154)	3.08903200
20	Abnormal hemoglobin (HP:0011902)	3.08397702
21	Cerebral edema (HP:0002181)	3.04837813
22	Stenosis of the external auditory canal (HP:0000402)	3.00524840
23	Absent thumb (HP:0009777)	3.00520283
24	Medial flaring of the eyebrow (HP:0010747)	2.90254622
25	Optic disc pallor (HP:0000543)	2.87949673
26	Lipid accumulation in hepatocytes (HP:0006561)	2.82612667
27	Constricted visual fields (HP:0001133)	2.76607934
28	Pancreatic fibrosis (HP:0100732)	2.75821287
29	Abnormality of midbrain morphology (HP:0002418)	2.74080956
30	Molar tooth sign on MRI (HP:0002419)	2.74080956
31	3-Methylglutaconic aciduria (HP:0003535)	2.72265736
32	Methylmalonic acidemia (HP:0002912)	2.69693803
33	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.67515896
34	Colon cancer (HP:0003003)	2.65707875
35	Genetic anticipation (HP:0003743)	2.64723300
36	Type II lissencephaly (HP:0007260)	2.58596199
37	Gait imbalance (HP:0002141)	2.38978365
38	Nephrogenic diabetes insipidus (HP:0009806)	2.36386514
39	Congenital primary aphakia (HP:0007707)	2.35620269
40	Renal Fanconi syndrome (HP:0001994)	2.33873056
41	Hypoplasia of the radius (HP:0002984)	2.32969314
42	Renal cortical cysts (HP:0000803)	2.31907584
43	Pendular nystagmus (HP:0012043)	2.31268128
44	Pancreatic cysts (HP:0001737)	2.30156127
45	Abolished electroretinogram (ERG) (HP:0000550)	2.27485265
46	Congenital, generalized hypertrichosis (HP:0004540)	2.26555147
47	Respiratory failure (HP:0002878)	2.26421064
48	Abnormality of the labia minora (HP:0012880)	2.24996973
49	Progressive cerebellar ataxia (HP:0002073)	2.24643349
50	Absent septum pellucidum (HP:0001331)	2.24606919
51	Methylmalonic aciduria (HP:0012120)	2.23115366
52	Depressed nasal ridge (HP:0000457)	2.23010589
53	Abnormality of the renal cortex (HP:0011035)	2.21727697
54	Increased serum lactate (HP:0002151)	2.17934885
55	Increased intramyocellular lipid droplets (HP:0012240)	2.17852580
56	Lactic acidosis (HP:0003128)	2.16870778
57	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.14707631
58	Lethargy (HP:0001254)	2.11622764
59	Hypoplasia of the ulna (HP:0003022)	2.11043402
60	Optic nerve hypoplasia (HP:0000609)	2.10300383
61	True hermaphroditism (HP:0010459)	2.09299350
62	Forearm undergrowth (HP:0009821)	2.06581553
63	Nephronophthisis (HP:0000090)	2.03199429
64	Myokymia (HP:0002411)	2.01589745
65	Abnormality of renal resorption (HP:0011038)	1.96432807
66	Respiratory difficulties (HP:0002880)	1.93176962
67	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.92052413
68	Abnormality of the renal medulla (HP:0100957)	1.90578212
69	Maternal diabetes (HP:0009800)	1.90461161
70	Horseshoe kidney (HP:0000085)	1.89754926
71	Vaginal atresia (HP:0000148)	1.89175545
72	Leukodystrophy (HP:0002415)	1.89008933
73	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.87193594
74	Asplenia (HP:0001746)	1.84875317
75	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.81399829
76	Genital tract atresia (HP:0001827)	1.80945982
77	Adrenal hypoplasia (HP:0000835)	1.79099918
78	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.78862393
79	Triphalangeal thumb (HP:0001199)	1.76595904
80	Hyperphosphaturia (HP:0003109)	1.76260821
81	Cerebellar dysplasia (HP:0007033)	1.75534021
82	Exertional dyspnea (HP:0002875)	1.74330160
83	Poor coordination (HP:0002370)	1.73838847
84	Increased muscle lipid content (HP:0009058)	1.72856308
85	Myotonia (HP:0002486)	1.71855507
86	Parakeratosis (HP:0001036)	1.70436742
87	Hip dysplasia (HP:0001385)	1.70312224
88	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.69038835
89	Testicular atrophy (HP:0000029)	1.68477462
90	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.68226588
91	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.68122993
92	Partial duplication of thumb phalanx (HP:0009944)	1.66823552
93	Growth hormone deficiency (HP:0000824)	1.66714899
94	Abnormality of urine glucose concentration (HP:0011016)	1.66340757
95	Glycosuria (HP:0003076)	1.66340757
96	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.65290368
97	Muscle hypertrophy of the lower extremities (HP:0008968)	1.64938888
98	Rib fusion (HP:0000902)	1.64386261
99	Exercise intolerance (HP:0003546)	1.61750316
100	Attenuation of retinal blood vessels (HP:0007843)	1.61137838

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	3.57759454
2	NME1	3.31612450
3	TXK	3.18639021
4	BCKDK	2.91050340
5	GRK1	2.56518451
6	TIE1	2.48171395
7	TRPM7	2.38611213
8	PDK2	2.31307082
9	VRK2	2.24134850
10	WNK4	2.15472342
11	CDC7	1.94630750
12	NUAK1	1.92621418
13	NEK1	1.90936979
14	ADRBK2	1.90663596
15	STK16	1.88382645
16	ZAK	1.86561891
17	PINK1	1.85968478
18	NME2	1.71372721
19	TLK1	1.58159219
20	OXSR1	1.57357052
21	TAF1	1.54109668
22	MAP3K11	1.49383010
23	DYRK2	1.48199942
24	VRK1	1.44266931
25	KIT	1.43832436
26	PIK3CA	1.43162684
27	MAP4K1	1.41488656
28	TNK2	1.38710900
29	CAMKK2	1.31773687
30	MAP3K12	1.25568163
31	STK39	1.21289504
32	PRKCG	1.13712308
33	TYRO3	1.13559022
34	MAP4K2	1.07813888
35	TNIK	1.04547172
36	BUB1	1.01983222
37	INSRR	1.01763265
38	WNK3	1.00067180
39	CAMK1	0.99887103
40	EPHB2	0.99336438
41	MATK	0.98508960
42	AURKA	0.98157496
43	CSNK2A2	0.91930896
44	CDK8	0.88291176
45	MKNK1	0.87422585
46	PASK	0.84166043
47	PAK3	0.82592698
48	MAP2K7	0.80946043
49	NEK2	0.80902199
50	TRIM28	0.80041816
51	FES	0.76215040
52	IRAK4	0.75697599
53	TEC	0.73054585
54	CSNK1G3	0.72979851
55	TGFBR1	0.72967797
56	ILK	0.70798666
57	AURKB	0.70513308
58	BMPR1B	0.70288933
59	PLK1	0.70238081
60	DAPK3	0.67706481
61	PHKG2	0.67519055
62	PHKG1	0.67519055
63	CAMKK1	0.66757524
64	PLK4	0.66743422
65	PLK3	0.66635757
66	NTRK2	0.65652180
67	MAP3K4	0.62807289
68	LRRK2	0.62118572
69	BRSK1	0.60915845
70	CSNK1E	0.59696085
71	SCYL2	0.59076988
72	PRKCQ	0.58988129
73	CSNK1G1	0.58582874
74	CSNK1A1L	0.58201037
75	ADRBK1	0.57923698
76	CSNK1G2	0.56965861
77	CAMK1D	0.56546096
78	CSNK2A1	0.55973390
79	PIM2	0.55843003
80	DYRK1B	0.55582536
81	RPS6KA5	0.53792711
82	CDK3	0.53043105
83	CSNK1A1	0.52962750
84	PRKACA	0.52292102
85	MKNK2	0.51827542
86	MAPKAPK5	0.51541033
87	BCR	0.49574597
88	PRKCZ	0.48783148
89	CHEK2	0.47731748
90	MAP3K9	0.46691670
91	ABL2	0.45850153
92	MAP2K4	0.45275640
93	LIMK1	0.43074275
94	RPS6KA6	0.42009032
95	OBSCN	0.40580353
96	LYN	0.38742260
97	MAP2K6	0.37180759
98	NTRK3	0.36635886
99	EPHA4	0.35667673
100	PRKCA	0.35327605

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.81985809
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.65355110
3	Parkinsons disease_Homo sapiens_hsa05012	3.80876227
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.72985426
5	Huntingtons disease_Homo sapiens_hsa05016	2.62941752
6	Alzheimers disease_Homo sapiens_hsa05010	2.58019511
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.51808901
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.41620519
9	Proteasome_Homo sapiens_hsa03050	2.19376424
10	Homologous recombination_Homo sapiens_hsa03440	2.10825005
11	Protein export_Homo sapiens_hsa03060	1.99815832
12	RNA polymerase_Homo sapiens_hsa03020	1.89421616
13	One carbon pool by folate_Homo sapiens_hsa00670	1.62220687
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.59550347
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.56373868
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.56279766
17	RNA degradation_Homo sapiens_hsa03018	1.55140126
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.54724254
19	Mismatch repair_Homo sapiens_hsa03430	1.52682021
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.47993770
21	Asthma_Homo sapiens_hsa05310	1.40645028
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.38041627
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.32700647
24	Allograft rejection_Homo sapiens_hsa05330	1.32056163
25	Propanoate metabolism_Homo sapiens_hsa00640	1.26066012
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26031969
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.22666474
28	Phototransduction_Homo sapiens_hsa04744	1.21369258
29	DNA replication_Homo sapiens_hsa03030	1.20775215
30	Sulfur relay system_Homo sapiens_hsa04122	1.17318462
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.15302178
32	Spliceosome_Homo sapiens_hsa03040	1.14350592
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.12893579
34	Type I diabetes mellitus_Homo sapiens_hsa04940	1.10356695
35	Butanoate metabolism_Homo sapiens_hsa00650	1.03272670
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01916172
37	Nucleotide excision repair_Homo sapiens_hsa03420	0.99917669
38	Basal transcription factors_Homo sapiens_hsa03022	0.96747468
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.96272042
40	Caffeine metabolism_Homo sapiens_hsa00232	0.96180571
41	Peroxisome_Homo sapiens_hsa04146	0.95981098
42	Nicotine addiction_Homo sapiens_hsa05033	0.95021887
43	Fat digestion and absorption_Homo sapiens_hsa04975	0.93767037
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.91948348
45	Folate biosynthesis_Homo sapiens_hsa00790	0.91067732
46	Base excision repair_Homo sapiens_hsa03410	0.91048468
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90021579
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.88539603
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83328086
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.82168743
51	Purine metabolism_Homo sapiens_hsa00230	0.81631254
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.81075014
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80869148
54	Fatty acid elongation_Homo sapiens_hsa00062	0.76311991
55	RNA transport_Homo sapiens_hsa03013	0.73611412
56	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.73408479
57	Non-homologous end-joining_Homo sapiens_hsa03450	0.69392090
58	African trypanosomiasis_Homo sapiens_hsa05143	0.67643685
59	Metabolic pathways_Homo sapiens_hsa01100	0.65828974
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64254071
61	Mineral absorption_Homo sapiens_hsa04978	0.64011700
62	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.63205737
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61921101
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60172202
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.59369522
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57378769
67	Phenylalanine metabolism_Homo sapiens_hsa00360	0.55866629
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54645904
69	Olfactory transduction_Homo sapiens_hsa04740	0.53530580
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.53366645
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.53243855
72	Rheumatoid arthritis_Homo sapiens_hsa05323	0.53068354
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.49639085
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49548413
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.49463269
76	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.47571840
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.46104615
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45687054
79	Fatty acid degradation_Homo sapiens_hsa00071	0.43945393
80	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43677475
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42302632
82	Sulfur metabolism_Homo sapiens_hsa00920	0.40635035
83	Morphine addiction_Homo sapiens_hsa05032	0.37673690
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.37579932
85	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36190373
86	Retinol metabolism_Homo sapiens_hsa00830	0.35537232
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.32519421
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30809734
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.29021216
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.27501583
91	Taste transduction_Homo sapiens_hsa04742	0.27421741
92	Basal cell carcinoma_Homo sapiens_hsa05217	0.25615626
93	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.22550074
94	Selenocompound metabolism_Homo sapiens_hsa00450	0.21713222
95	Insulin secretion_Homo sapiens_hsa04911	0.17423044
96	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.16520969
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.15710232
98	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.14870476
99	Regulation of autophagy_Homo sapiens_hsa04140	0.14474470
100	Salivary secretion_Homo sapiens_hsa04970	0.12392105

RPL10AP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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