ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	8.67390931
2	viral transcription (GO:0019083)	8.26113121
3	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	8.04799865
4	translational termination (GO:0006415)	7.87306090
5	ribosomal small subunit biogenesis (GO:0042274)	7.73832781
6	establishment of protein localization to mitochondrial membrane (GO:0090151)	7.72862277
7	pyrimidine nucleotide catabolic process (GO:0006244)	7.01930306
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.70945306
9	translational elongation (GO:0006414)	6.66499553
10	cotranslational protein targeting to membrane (GO:0006613)	6.55639120
11	protein targeting to ER (GO:0045047)	6.49427640
12	ribosomal small subunit assembly (GO:0000028)	6.48472921
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.24167935
14	protein localization to endoplasmic reticulum (GO:0070972)	6.12631062
15	viral life cycle (GO:0019058)	6.03178266
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.00430321
17	ATP synthesis coupled proton transport (GO:0015986)	6.00430321
18	cellular protein complex disassembly (GO:0043624)	5.89179061
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.80753491
20	maturation of SSU-rRNA (GO:0030490)	5.76598649
21	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.76151257
22	translational initiation (GO:0006413)	5.67625354
23	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.53323792
24	peptidyl-histidine modification (GO:0018202)	5.52777338
25	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	5.39400243
26	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	5.09117679
27	protein complex biogenesis (GO:0070271)	4.92877634
28	electron transport chain (GO:0022900)	4.91582495
29	respiratory electron transport chain (GO:0022904)	4.89765561
30	protein complex disassembly (GO:0043241)	4.89186411
31	translation (GO:0006412)	4.87827848
32	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.83640172
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.75732978
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.75732978
35	NADH dehydrogenase complex assembly (GO:0010257)	4.75732978
36	preassembly of GPI anchor in ER membrane (GO:0016254)	4.72478128
37	macromolecular complex disassembly (GO:0032984)	4.58037980
38	mitochondrial respiratory chain complex assembly (GO:0033108)	4.56992841
39	water-soluble vitamin biosynthetic process (GO:0042364)	4.53623559
40	protein targeting to mitochondrion (GO:0006626)	4.39121875
41	receptor guanylyl cyclase signaling pathway (GO:0007168)	4.38331956
42	DNA deamination (GO:0045006)	4.36732682
43	inner mitochondrial membrane organization (GO:0007007)	4.36322153
44	deoxyribonucleotide catabolic process (GO:0009264)	4.28144173
45	protein targeting to membrane (GO:0006612)	4.24060009
46	ribosomal large subunit biogenesis (GO:0042273)	4.13693828
47	respiratory chain complex IV assembly (GO:0008535)	4.11387131
48	deoxyribose phosphate catabolic process (GO:0046386)	4.03055043
49	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.96934292
50	establishment of protein localization to mitochondrion (GO:0072655)	3.92824743
51	cytochrome complex assembly (GO:0017004)	3.82700981
52	intracellular protein transmembrane import (GO:0044743)	3.81197243
53	base-excision repair, AP site formation (GO:0006285)	3.80055206
54	GPI anchor biosynthetic process (GO:0006506)	3.79913502
55	ATP biosynthetic process (GO:0006754)	3.78946496
56	protein localization to mitochondrion (GO:0070585)	3.78615468
57	protein neddylation (GO:0045116)	3.73564858
58	mRNA catabolic process (GO:0006402)	3.72632122
59	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.62409201
60	rRNA processing (GO:0006364)	3.58368432
61	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.57320203
62	kynurenine metabolic process (GO:0070189)	3.53753782
63	GPI anchor metabolic process (GO:0006505)	3.52128024
64	rRNA metabolic process (GO:0016072)	3.41323921
65	male meiosis I (GO:0007141)	3.41178865
66	cellular component biogenesis (GO:0044085)	3.40934195
67	termination of RNA polymerase III transcription (GO:0006386)	3.39969899
68	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.39969899
69	iron-sulfur cluster assembly (GO:0016226)	3.32015507
70	metallo-sulfur cluster assembly (GO:0031163)	3.32015507
71	mitochondrial transport (GO:0006839)	3.31065495
72	RNA catabolic process (GO:0006401)	3.29435072
73	oxidative phosphorylation (GO:0006119)	3.26990268
74	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.25724266
75	hydrogen ion transmembrane transport (GO:1902600)	3.20817119
76	mitochondrial calcium ion transport (GO:0006851)	3.20545777
77	ribonucleoprotein complex biogenesis (GO:0022613)	3.19178976
78	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	3.18739941
79	GTP biosynthetic process (GO:0006183)	3.10041100
80	protein targeting (GO:0006605)	3.07961053
81	indole-containing compound catabolic process (GO:0042436)	3.07481369
82	indolalkylamine catabolic process (GO:0046218)	3.07481369
83	tryptophan catabolic process (GO:0006569)	3.07481369
84	2-deoxyribonucleotide metabolic process (GO:0009394)	3.04590543
85	establishment of protein localization to membrane (GO:0090150)	3.03330320
86	protein-cofactor linkage (GO:0018065)	2.95707930
87	pseudouridine synthesis (GO:0001522)	2.94709526
88	intracellular protein transmembrane transport (GO:0065002)	2.94163211
89	purine nucleotide salvage (GO:0032261)	2.93179003
90	spliceosomal snRNP assembly (GO:0000387)	2.91511090
91	nucleoside triphosphate biosynthetic process (GO:0009142)	2.85283137
92	motile cilium assembly (GO:0044458)	2.84773840
93	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.83573953
94	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.83573953
95	establishment of protein localization to organelle (GO:0072594)	2.82682560
96	proteasome assembly (GO:0043248)	2.82137096
97	deoxyribose phosphate metabolic process (GO:0019692)	2.79087794
98	protein transmembrane transport (GO:0071806)	2.78751112
99	aerobic respiration (GO:0009060)	2.78695852
100	positive regulation of prostaglandin secretion (GO:0032308)	2.78291562

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	6.02483661
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.84178887
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.75598276
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.57442686
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.51069249
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.46169688
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.39752510
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.33866948
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.12624491
10	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	3.03780142
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.53128329
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.52123030
13	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.43710907
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.39458350
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.32428903
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.32183854
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.24197304
18	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.20537096
19	ZNF274_21170338_ChIP-Seq_K562_Hela	2.16884979
20	IRF1_19129219_ChIP-ChIP_H3396_Human	2.10147271
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.03998184
22	XRN2_22483619_ChIP-Seq_HELA_Human	1.97040554
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.96304240
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.95096681
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.92779972
26	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.80027127
27	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.77966288
28	GABP_19822575_ChIP-Seq_HepG2_Human	1.77166140
29	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.75168733
30	TTF2_22483619_ChIP-Seq_HELA_Human	1.74245618
31	VDR_22108803_ChIP-Seq_LS180_Human	1.73621519
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.71387946
33	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.71140607
34	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.67939806
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.66525672
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.64767940
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.61940542
38	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.59494406
39	ZNF263_19887448_ChIP-Seq_K562_Human	1.55027407
40	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.48835923
41	DCP1A_22483619_ChIP-Seq_HELA_Human	1.48532897
42	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.45063610
43	STAT1_20625510_ChIP-Seq_HELA_Human	1.42977265
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40451086
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36940450
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.35273107
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.33399993
48	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.31870184
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.29128165
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.23978189
51	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.23548074
52	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.21976417
53	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.20675759
54	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.17315275
55	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16827119
56	BCL6_27268052_Chip-Seq_Bcells_Human	1.15747870
57	P300_27268052_Chip-Seq_Bcells_Human	1.13784878
58	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.13001057
59	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.12553135
60	CIITA_25753668_ChIP-Seq_RAJI_Human	1.11672652
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10955132
62	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.10193958
63	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.09257147
64	KDM5A_27292631_Chip-Seq_BREAST_Human	1.06396639
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.06176725
66	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.06052431
67	CTCF_20526341_ChIP-Seq_ESCs_Human	1.05788822
68	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.05483738
69	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.05308299
70	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.04143143
71	E2F1_20622854_ChIP-Seq_HELA_Human	1.02286241
72	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01389692
73	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99580812
74	VDR_21846776_ChIP-Seq_THP-1_Human	0.99258965
75	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.98940880
76	AR_20517297_ChIP-Seq_VCAP_Human	0.97821992
77	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97506527
78	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.96709745
79	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96457235
80	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.96180626
81	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.94588667
82	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94345680
83	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.93158367
84	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.92847812
85	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.92768741
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92266683
87	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.92080328
88	HTT_18923047_ChIP-ChIP_STHdh_Human	0.91284969
89	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.90913960
90	ERG_20517297_ChIP-Seq_VCAP_Human	0.90907590
91	RAC3_21632823_ChIP-Seq_H3396_Human	0.90902535
92	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.90074252
93	MYC_19829295_ChIP-Seq_ESCs_Human	0.89383792
94	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.88337314
95	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.87818586
96	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.87105558
97	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.85996352
98	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.84447352
99	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.83987524
100	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.82827942

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.05290248
2	MP0006292_abnormal_olfactory_placode	3.70225532
3	MP0005670_abnormal_white_adipose	3.49055531
4	MP0003646_muscle_fatigue	3.32491660
5	MP0002163_abnormal_gland_morphology	3.22415844
6	MP0008789_abnormal_olfactory_epithelium	3.11907945
7	MP0005646_abnormal_pituitary_gland	3.10046638
8	MP0003011_delayed_dark_adaptation	2.74435794
9	MP0003786_premature_aging	2.67934372
10	MP0006036_abnormal_mitochondrial_physio	2.60841461
11	MP0008875_abnormal_xenobiotic_pharmacok	2.45616510
12	MP0002837_dystrophic_cardiac_calcinosis	2.43515234
13	MP0002277_abnormal_respiratory_mucosa	2.31017020
14	MP0005394_taste/olfaction_phenotype	2.21588750
15	MP0005499_abnormal_olfactory_system	2.21588750
16	MP0003806_abnormal_nucleotide_metabolis	2.00974564
17	MP0000631_abnormal_neuroendocrine_gland	1.87222388
18	MP0005379_endocrine/exocrine_gland_phen	1.86697621
19	MP0003195_calcinosis	1.85574708
20	MP0003941_abnormal_skin_development	1.84130142
21	MP0004885_abnormal_endolymph	1.83843189
22	MP0000678_abnormal_parathyroid_gland	1.79426980
23	MP0009053_abnormal_anal_canal	1.77292077
24	MP0000049_abnormal_middle_ear	1.71285767
25	MP0004043_abnormal_pH_regulation	1.70484345
26	MP0000467_abnormal_esophagus_morphology	1.67547772
27	MP0000372_irregular_coat_pigmentation	1.62500347
28	MP0003938_abnormal_ear_development	1.57471321
29	MP0002095_abnormal_skin_pigmentation	1.57460677
30	MP0001986_abnormal_taste_sensitivity	1.57304937
31	MP0002234_abnormal_pharynx_morphology	1.55853100
32	MP0004036_abnormal_muscle_relaxation	1.55543159
33	MP0004145_abnormal_muscle_electrophysio	1.55224625
34	MP0002909_abnormal_adrenal_gland	1.53690444
35	MP0002233_abnormal_nose_morphology	1.42106453
36	MP0008995_early_reproductive_senescence	1.42003123
37	MP0002160_abnormal_reproductive_system	1.41210815
38	MP0006072_abnormal_retinal_apoptosis	1.40010126
39	MP0003119_abnormal_digestive_system	1.39473249
40	MP0002938_white_spotting	1.36595802
41	MP0008057_abnormal_DNA_replication	1.33566390
42	MP0005389_reproductive_system_phenotype	1.31520415
43	MP0001919_abnormal_reproductive_system	1.29975275
44	MP0002102_abnormal_ear_morphology	1.24555897
45	MP0003136_yellow_coat_color	1.22271118
46	MP0008775_abnormal_heart_ventricle	1.20516426
47	MP0002751_abnormal_autonomic_nervous	1.16693386
48	MP0009333_abnormal_splenocyte_physiolog	1.16090016
49	MP0006276_abnormal_autonomic_nervous	1.13968007
50	MP0003186_abnormal_redox_activity	1.10105463
51	MP0005551_abnormal_eye_electrophysiolog	1.06889974
52	MP0003693_abnormal_embryo_hatching	1.06853491
53	MP0009046_muscle_twitch	1.05965433
54	MP0002876_abnormal_thyroid_physiology	1.03759038
55	MP0001529_abnormal_vocalization	1.02492264
56	MP0005075_abnormal_melanosome_morpholog	1.01968757
57	MP0005174_abnormal_tail_pigmentation	1.00310639
58	MP0001881_abnormal_mammary_gland	0.92232170
59	MP0008872_abnormal_physiological_respon	0.91372408
60	MP0001905_abnormal_dopamine_level	0.91277696
61	MP0000427_abnormal_hair_cycle	0.90227205
62	MP0000015_abnormal_ear_pigmentation	0.89218033
63	MP0001486_abnormal_startle_reflex	0.86734926
64	MP0005253_abnormal_eye_physiology	0.86477947
65	MP0008058_abnormal_DNA_repair	0.86072501
66	MP0003123_paternal_imprinting	0.84463096
67	MP0001764_abnormal_homeostasis	0.81226968
68	MP0009250_abnormal_appendicular_skeleto	0.80957984
69	MP0000613_abnormal_salivary_gland	0.80057595
70	MP0003137_abnormal_impulse_conducting	0.79050107
71	MP0003724_increased_susceptibility_to	0.78727138
72	MP0004142_abnormal_muscle_tone	0.76298029
73	MP0003879_abnormal_hair_cell	0.75120892
74	MP0001293_anophthalmia	0.74991245
75	MP0001984_abnormal_olfaction	0.73437630
76	MP0002736_abnormal_nociception_after	0.73253591
77	MP0000647_abnormal_sebaceous_gland	0.72606444
78	MP0005671_abnormal_response_to	0.71685336
79	MP0003953_abnormal_hormone_level	0.68761570
80	MP0009745_abnormal_behavioral_response	0.63990231
81	MP0006035_abnormal_mitochondrial_morpho	0.61546680
82	MP0000681_abnormal_thyroid_gland	0.60855574
83	MP0005387_immune_system_phenotype	0.60505214
84	MP0001790_abnormal_immune_system	0.60505214
85	MP0002210_abnormal_sex_determination	0.59169579
86	MP0001663_abnormal_digestive_system	0.58403163
87	MP0003763_abnormal_thymus_physiology	0.58284165
88	MP0005503_abnormal_tendon_morphology	0.58280817
89	MP0005187_abnormal_penis_morphology	0.58132162
90	MP0000639_abnormal_adrenal_gland	0.57951366
91	MP0004858_abnormal_nervous_system	0.56130773
92	MP0003937_abnormal_limbs/digits/tail_de	0.56069855
93	MP0009765_abnormal_xenobiotic_induced	0.56008168
94	MP0004130_abnormal_muscle_cell	0.55882809
95	MP0005636_abnormal_mineral_homeostasis	0.55716914
96	MP0000653_abnormal_sex_gland	0.55510115
97	MP0003315_abnormal_perineum_morphology	0.55353597
98	MP0005645_abnormal_hypothalamus_physiol	0.53551847
99	MP0005381_digestive/alimentary_phenotyp	0.53251877
100	MP0002272_abnormal_nervous_system	0.53045915

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Lipid accumulation in hepatocytes (HP:0006561)	5.62473976
2	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	5.43681819
3	Decreased activity of mitochondrial respiratory chain (HP:0008972)	5.43681819
4	Acute necrotizing encephalopathy (HP:0006965)	4.73721763
5	Mitochondrial inheritance (HP:0001427)	4.71403236
6	Abnormal mitochondria in muscle tissue (HP:0008316)	4.37567499
7	Hepatocellular necrosis (HP:0001404)	4.20793839
8	Increased muscle lipid content (HP:0009058)	4.19544005
9	Increased CSF lactate (HP:0002490)	4.18399400
10	Acute encephalopathy (HP:0006846)	4.12793725
11	Macrocytic anemia (HP:0001972)	4.04884502
12	Progressive macrocephaly (HP:0004481)	3.94413792
13	Hepatic necrosis (HP:0002605)	3.87995515
14	Increased hepatocellular lipid droplets (HP:0006565)	3.54679475
15	Nonprogressive disorder (HP:0003680)	3.52821260
16	Renal Fanconi syndrome (HP:0001994)	3.43493221
17	Reticulocytopenia (HP:0001896)	3.42339726
18	Colon cancer (HP:0003003)	3.39372070
19	Respiratory failure (HP:0002878)	3.37185404
20	Methylmalonic acidemia (HP:0002912)	3.34257317
21	Abnormal number of erythroid precursors (HP:0012131)	3.31274215
22	Methylmalonic aciduria (HP:0012120)	3.26019685
23	Abnormality of cells of the erythroid lineage (HP:0012130)	3.23714116
24	Broad distal phalanx of finger (HP:0009836)	3.17027072
25	Cerebral edema (HP:0002181)	3.06760076
26	Absent/shortened dynein arms (HP:0200106)	3.04104735
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.04104735
28	Pallor (HP:0000980)	3.04020283
29	Lactic acidosis (HP:0003128)	2.92836090
30	Panhypogammaglobulinemia (HP:0003139)	2.92745335
31	Tubulointerstitial nephritis (HP:0001970)	2.86313020
32	3-Methylglutaconic aciduria (HP:0003535)	2.77603266
33	Increased intramyocellular lipid droplets (HP:0012240)	2.72545653
34	Parakeratosis (HP:0001036)	2.71204681
35	Increased serum lactate (HP:0002151)	2.70198941
36	Neoplasm of head and neck (HP:0012288)	2.59224333
37	Esophageal neoplasm (HP:0100751)	2.59224333
38	Dicarboxylic aciduria (HP:0003215)	2.52317175
39	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.52317175
40	Glycosuria (HP:0003076)	2.47272647
41	Abnormality of urine glucose concentration (HP:0011016)	2.47272647
42	Testicular atrophy (HP:0000029)	2.36243750
43	Lethargy (HP:0001254)	2.35161523
44	Exertional dyspnea (HP:0002875)	2.33418526
45	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.31430662
46	Abnormality of renal resorption (HP:0011038)	2.23193434
47	Generalized aminoaciduria (HP:0002909)	2.18048737
48	Aplasia/hypoplasia of the uterus (HP:0008684)	2.17856177
49	Exercise intolerance (HP:0003546)	2.17690823
50	Abnormality of midbrain morphology (HP:0002418)	2.17270834
51	Molar tooth sign on MRI (HP:0002419)	2.17270834
52	Hip dysplasia (HP:0001385)	2.13146949
53	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.12129001
54	Mutism (HP:0002300)	2.11446326
55	Myokymia (HP:0002411)	2.10976244
56	Respiratory difficulties (HP:0002880)	2.10429624
57	Concave nail (HP:0001598)	2.09229844
58	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.07994289
59	Cerebral hypomyelination (HP:0006808)	2.05405097
60	Type 2 muscle fiber atrophy (HP:0003554)	1.98174021
61	Hyperglycinemia (HP:0002154)	1.96392371
62	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.96386630
63	Hypoplasia of the uterus (HP:0000013)	1.95856728
64	Agammaglobulinemia (HP:0004432)	1.95591178
65	Cerebral hemorrhage (HP:0001342)	1.94494461
66	Absent thumb (HP:0009777)	1.93211459
67	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.91755588
68	Abnormality of the middle phalanges of the toes (HP:0010183)	1.91382045
69	Pancreatic fibrosis (HP:0100732)	1.90035947
70	Muscle fiber atrophy (HP:0100295)	1.88777104
71	Hyperphosphaturia (HP:0003109)	1.88145095
72	Optic disc pallor (HP:0000543)	1.87877719
73	Leukodystrophy (HP:0002415)	1.86265721
74	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.86025764
75	Congenital stationary night blindness (HP:0007642)	1.85519640
76	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.85331845
77	Renal tubular dysfunction (HP:0000124)	1.83806298
78	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.83665744
79	Abnormal respiratory motile cilium morphology (HP:0005938)	1.80894267
80	Abnormal respiratory epithelium morphology (HP:0012253)	1.80894267
81	Conjugated hyperbilirubinemia (HP:0002908)	1.80310824
82	Nephrogenic diabetes insipidus (HP:0009806)	1.78859530
83	Rectal prolapse (HP:0002035)	1.77163312
84	Abnormal drinking behavior (HP:0030082)	1.76459595
85	Polydipsia (HP:0001959)	1.76459595
86	Chronic bronchitis (HP:0004469)	1.75386559
87	Abnormality of the right ventricle (HP:0001707)	1.75359413
88	Congenital, generalized hypertrichosis (HP:0004540)	1.74775411
89	Enlarged kidneys (HP:0000105)	1.72721445
90	Pancreatic cysts (HP:0001737)	1.71788667
91	CNS demyelination (HP:0007305)	1.71758577
92	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.69997563
93	Microvesicular hepatic steatosis (HP:0001414)	1.68779327
94	Fibular aplasia (HP:0002990)	1.67656565
95	Corneal dystrophy (HP:0001131)	1.67515244
96	Abnormality of vitamin B metabolism (HP:0004340)	1.67230505
97	Anencephaly (HP:0002323)	1.66139375
98	Pendular nystagmus (HP:0012043)	1.63948678
99	Respiratory distress (HP:0002098)	1.63799012
100	Abnormal respiratory motile cilium physiology (HP:0012261)	1.61332916

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	5.71054765
2	NME2	3.62950133
3	STK16	3.35383769
4	CDK19	3.18329475
5	ADRBK2	3.10201029
6	MAP2K2	3.01232281
7	MST4	2.48562747
8	BMPR1B	2.42731065
9	LRRK2	2.41050857
10	NEK1	2.36066502
11	BCKDK	2.13767259
12	ILK	2.11617586
13	NUAK1	2.00103074
14	IKBKE	1.92072752
15	IRAK2	1.72419080
16	TLK1	1.72137691
17	PDK2	1.70342734
18	ADRBK1	1.61920640
19	DYRK2	1.57677715
20	WNK4	1.50353404
21	NLK	1.49590605
22	STK10	1.48893590
23	TBK1	1.40175895
24	CSNK1A1L	1.27638337
25	CSNK1G3	1.26617796
26	PIK3CG	1.26574232
27	STK24	1.25577619
28	FRK	1.25382305
29	DAPK2	1.22905542
30	PLK4	1.15639821
31	IKBKB	1.12813887
32	GRK1	1.11807151
33	MAP3K8	1.10208305
34	STK11	1.09659871
35	ABL2	1.06573117
36	TEC	0.99839043
37	CSNK1G1	0.98920117
38	ZAK	0.98267117
39	CSNK1G2	0.95905752
40	BUB1	0.92888563
41	RPS6KA5	0.88119923
42	GRK5	0.87921587
43	STK39	0.84820322
44	PIK3CA	0.84691672
45	INSRR	0.84582065
46	VRK2	0.81345426
47	TXK	0.81336602
48	MAPK13	0.78276596
49	LIMK1	0.76383253
50	MAP4K2	0.75842383
51	MAP2K1	0.75045316
52	CCNB1	0.72408180
53	PINK1	0.71707121
54	CSNK2A2	0.70388240
55	DYRK1A	0.67307755
56	DAPK3	0.64618960
57	AURKB	0.62185218
58	PHKG1	0.59989239
59	PHKG2	0.59989239
60	MAPK15	0.59185729
61	CSNK2A1	0.57551162
62	TIE1	0.57243575
63	MAP2K6	0.55959185
64	TAOK3	0.55809057
65	PIM2	0.54976980
66	WNK1	0.54887940
67	GRK7	0.51229192
68	CAMKK2	0.50324780
69	EIF2AK1	0.49998631
70	OBSCN	0.48384072
71	ABL1	0.48149268
72	CDK8	0.47866657
73	PRKACA	0.47083555
74	SYK	0.45567405
75	MATK	0.45378708
76	CSNK1A1	0.44946778
77	PRKCA	0.44888784
78	BRSK2	0.41886119
79	AURKA	0.40738771
80	MKNK2	0.40694688
81	CSNK1E	0.40128368
82	PLK1	0.39463798
83	PAK1	0.39291635
84	CSNK1D	0.38787094
85	BRSK1	0.38691398
86	DAPK1	0.38491111
87	NME1	0.37663393
88	PRKCQ	0.37192349
89	GRK6	0.36342402
90	PRKG1	0.34348312
91	MELK	0.32565610
92	MINK1	0.32159027
93	MARK3	0.31636263
94	PIM1	0.31559379
95	LYN	0.30024707
96	MAP3K12	0.28201011
97	PRKCG	0.27792048
98	ITK	0.26472385
99	CDC7	0.25684126
100	PRKCI	0.25648047

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.66744711
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.45859978
3	Parkinsons disease_Homo sapiens_hsa05012	3.87210444
4	Sulfur relay system_Homo sapiens_hsa04122	3.64774302
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.00362076
6	Asthma_Homo sapiens_hsa05310	2.84688069
7	Caffeine metabolism_Homo sapiens_hsa00232	2.77548371
8	Huntingtons disease_Homo sapiens_hsa05016	2.65000984
9	Alzheimers disease_Homo sapiens_hsa05010	2.62669322
10	RNA polymerase_Homo sapiens_hsa03020	2.56903926
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.22948994
12	Allograft rejection_Homo sapiens_hsa05330	1.99621104
13	Proteasome_Homo sapiens_hsa03050	1.89132112
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.86692293
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.86204514
16	Pyrimidine metabolism_Homo sapiens_hsa00240	1.71652929
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.65582927
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.64302740
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.57055657
20	One carbon pool by folate_Homo sapiens_hsa00670	1.56046899
21	DNA replication_Homo sapiens_hsa03030	1.47146451
22	Homologous recombination_Homo sapiens_hsa03440	1.41943075
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.31458520
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.26852584
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.26458531
26	Base excision repair_Homo sapiens_hsa03410	1.24292847
27	Phototransduction_Homo sapiens_hsa04744	1.17595652
28	Protein export_Homo sapiens_hsa03060	1.14671673
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14607532
30	Purine metabolism_Homo sapiens_hsa00230	1.11953497
31	Viral myocarditis_Homo sapiens_hsa05416	1.10419389
32	Olfactory transduction_Homo sapiens_hsa04740	1.07847723
33	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.06357345
34	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.05989732
35	Collecting duct acid secretion_Homo sapiens_hsa04966	1.04837108
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01076738
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.00901652
38	Rheumatoid arthritis_Homo sapiens_hsa05323	0.98789898
39	Mismatch repair_Homo sapiens_hsa03430	0.96742413
40	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.95227835
41	Sulfur metabolism_Homo sapiens_hsa00920	0.93346904
42	Fanconi anemia pathway_Homo sapiens_hsa03460	0.91824029
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.89161714
44	Linoleic acid metabolism_Homo sapiens_hsa00591	0.83777404
45	Primary immunodeficiency_Homo sapiens_hsa05340	0.82635607
46	Antigen processing and presentation_Homo sapiens_hsa04612	0.78987303
47	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.77749952
48	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.76128920
49	Metabolic pathways_Homo sapiens_hsa01100	0.75204910
50	Nucleotide excision repair_Homo sapiens_hsa03420	0.72059652
51	Spliceosome_Homo sapiens_hsa03040	0.68848551
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.67608611
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.66514927
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.65703804
55	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.62961258
56	Basal transcription factors_Homo sapiens_hsa03022	0.60733806
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57988472
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57869577
59	RNA transport_Homo sapiens_hsa03013	0.56301239
60	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.54986903
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54530967
62	RNA degradation_Homo sapiens_hsa03018	0.50875496
63	p53 signaling pathway_Homo sapiens_hsa04115	0.49185046
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48609221
65	Retinol metabolism_Homo sapiens_hsa00830	0.47576856
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47470249
67	Peroxisome_Homo sapiens_hsa04146	0.45998514
68	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.42527921
69	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.40785055
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40700383
71	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.40279326
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.39765753
73	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38264094
74	Glutathione metabolism_Homo sapiens_hsa00480	0.37600864
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.37227123
76	Tyrosine metabolism_Homo sapiens_hsa00350	0.36269593
77	Propanoate metabolism_Homo sapiens_hsa00640	0.35295947
78	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.34811713
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33268355
80	Pyruvate metabolism_Homo sapiens_hsa00620	0.32483669
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31902461
82	Nitrogen metabolism_Homo sapiens_hsa00910	0.31787656
83	Folate biosynthesis_Homo sapiens_hsa00790	0.31519724
84	Serotonergic synapse_Homo sapiens_hsa04726	0.28259558
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.27852395
86	Fatty acid degradation_Homo sapiens_hsa00071	0.27130243
87	Morphine addiction_Homo sapiens_hsa05032	0.25443092
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.25158695
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.24931670
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.24621194
91	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.24315860
92	Nicotine addiction_Homo sapiens_hsa05033	0.23363020
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.20642213
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.20499473
95	GABAergic synapse_Homo sapiens_hsa04727	0.15799052
96	Tuberculosis_Homo sapiens_hsa05152	0.15700035
97	Leishmaniasis_Homo sapiens_hsa05140	0.15067197
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.14245142
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.12835897
100	Circadian entrainment_Homo sapiens_hsa04713	0.12639102

RPL10AP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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