ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.65493529
2	ribosomal small subunit biogenesis (GO:0042274)	6.30915413
3	DNA deamination (GO:0045006)	6.19012034
4	viral transcription (GO:0019083)	5.52657612
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.39062698
6	translational termination (GO:0006415)	5.33252136
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.27637463
8	cytidine metabolic process (GO:0046087)	5.26354473
9	cytidine catabolic process (GO:0006216)	5.26354473
10	cytidine deamination (GO:0009972)	5.26354473
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.21891230
12	ATP synthesis coupled proton transport (GO:0015986)	5.21891230
13	translational elongation (GO:0006414)	4.76127481
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.75597951
15	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.71591608
16	maturation of SSU-rRNA (GO:0030490)	4.71447949
17	cotranslational protein targeting to membrane (GO:0006613)	4.62706729
18	protein targeting to ER (GO:0045047)	4.62015235
19	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.51014987
20	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.40532113
21	protein localization to endoplasmic reticulum (GO:0070972)	4.40511690
22	respiratory electron transport chain (GO:0022904)	4.19973288
23	electron transport chain (GO:0022900)	4.18062589
24	chaperone-mediated protein transport (GO:0072321)	4.07243479
25	cellular protein complex disassembly (GO:0043624)	4.05802575
26	ncRNA 3-end processing (GO:0043628)	4.04301543
27	viral life cycle (GO:0019058)	4.03890425
28	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.81242762
29	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.81025091
30	protein complex biogenesis (GO:0070271)	3.78864214
31	translational initiation (GO:0006413)	3.67626513
32	protein polyglutamylation (GO:0018095)	3.65322230
33	ribosomal large subunit biogenesis (GO:0042273)	3.61047421
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.60387239
35	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.60387239
36	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.57391796
37	translation (GO:0006412)	3.48515911
38	mitochondrial respiratory chain complex assembly (GO:0033108)	3.39177713
39	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.37819044
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.37441425
41	NADH dehydrogenase complex assembly (GO:0010257)	3.37441425
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.37441425
43	protein complex disassembly (GO:0043241)	3.32087357
44	ribonucleoprotein complex biogenesis (GO:0022613)	3.31803223
45	cellular component biogenesis (GO:0044085)	3.31600586
46	protein-cofactor linkage (GO:0018065)	3.24518179
47	protein neddylation (GO:0045116)	3.22220434
48	regulation of regulatory T cell differentiation (GO:0045589)	3.21529294
49	macromolecular complex disassembly (GO:0032984)	3.14754112
50	ATP biosynthetic process (GO:0006754)	3.08723413
51	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.07544744
52	termination of RNA polymerase III transcription (GO:0006386)	3.07544744
53	regulation of cellular amino acid metabolic process (GO:0006521)	3.07519784
54	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.04345256
55	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.01674472
56	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.01620670
57	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.01444789
58	respiratory chain complex IV assembly (GO:0008535)	2.97601979
59	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.96313337
60	cytochrome complex assembly (GO:0017004)	2.94984208
61	hydrogen ion transmembrane transport (GO:1902600)	2.94855573
62	rRNA processing (GO:0006364)	2.94517855
63	protein targeting to membrane (GO:0006612)	2.93498800
64	rRNA metabolic process (GO:0016072)	2.92681264
65	pyrimidine nucleotide catabolic process (GO:0006244)	2.92454886
66	water-soluble vitamin biosynthetic process (GO:0042364)	2.91737719
67	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.91195036
68	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.89638659
69	proton transport (GO:0015992)	2.88513363
70	proteasome assembly (GO:0043248)	2.88070227
71	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.87776729
72	negative regulation of T cell apoptotic process (GO:0070233)	2.84079959
73	hydrogen transport (GO:0006818)	2.82162535
74	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.80867681
75	behavioral response to nicotine (GO:0035095)	2.80569791
76	GTP biosynthetic process (GO:0006183)	2.79352827
77	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.78841646
78	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.78841646
79	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.78841646
80	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.78550082
81	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.76891485
82	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.76891485
83	base-excision repair, AP site formation (GO:0006285)	2.74084704
84	rRNA modification (GO:0000154)	2.72907341
85	mRNA catabolic process (GO:0006402)	2.72043329
86	regulation of T cell mediated cytotoxicity (GO:0001914)	2.70956062
87	metallo-sulfur cluster assembly (GO:0031163)	2.68397659
88	iron-sulfur cluster assembly (GO:0016226)	2.68397659
89	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.68049213
90	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.66904846
91	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.66904846
92	platelet dense granule organization (GO:0060155)	2.66613498
93	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.63370537
94	positive regulation of defense response to virus by host (GO:0002230)	2.62844965
95	mannosylation (GO:0097502)	2.59234938
96	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.58381054
97	regulation of interleukin-8 secretion (GO:2000482)	2.57291026
98	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.57199255
99	ubiquinone biosynthetic process (GO:0006744)	2.56901115
100	GPI anchor metabolic process (GO:0006505)	2.55761167

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.75128978
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.14460697
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.59557238
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.42364578
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.12231309
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.03694544
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.98237450
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.93528910
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.87449563
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.75900634
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.72834580
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.56202138
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.51548914
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.45411229
15	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.45114995
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.44741854
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.12943920
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.09600094
19	VDR_22108803_ChIP-Seq_LS180_Human	2.08042140
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.97442593
21	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.90680480
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.88689827
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88352587
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.88090731
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.81522019
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.80401369
27	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.74798788
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65198736
29	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.65074302
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64461398
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.64254350
32	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.59477542
33	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.52300965
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.51574823
35	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.46982509
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.45800699
37	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.43960031
38	NANOG_20526341_ChIP-Seq_ESCs_Human	1.42578430
39	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.40995283
40	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.39531782
41	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.38262760
42	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.36350609
43	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.35733239
44	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34165371
45	TAF2_19829295_ChIP-Seq_ESCs_Human	1.32341139
46	GATA3_26560356_Chip-Seq_TH2_Human	1.28179461
47	AR_20517297_ChIP-Seq_VCAP_Human	1.28072721
48	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.27694735
49	BCL6_27268052_Chip-Seq_Bcells_Human	1.27352132
50	TTF2_22483619_ChIP-Seq_HELA_Human	1.27307697
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25874525
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25874525
53	NCOR_22424771_ChIP-Seq_293T_Human	1.23496775
54	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.21657501
55	RUNX_20019798_ChIP-Seq_JUKART_Human	1.20060642
56	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.20013372
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18588762
58	MYB_26560356_Chip-Seq_TH2_Human	1.18411449
59	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.17623690
60	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.16415197
61	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.15171086
62	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14556936
63	GABP_19822575_ChIP-Seq_HepG2_Human	1.12008860
64	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.11640431
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09093722
66	ERG_20517297_ChIP-Seq_VCAP_Human	1.08769303
67	ERA_21632823_ChIP-Seq_H3396_Human	1.08234598
68	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.07311226
69	CIITA_25753668_ChIP-Seq_RAJI_Human	1.06906260
70	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.06840771
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06660666
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06549496
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06549496
74	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.05392846
75	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.05366192
76	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05129346
77	CTCF_20526341_ChIP-Seq_ESCs_Human	1.04583628
78	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.04207631
79	EWS_26573619_Chip-Seq_HEK293_Human	1.04158232
80	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.03366124
81	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.02931456
82	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.02181199
83	XRN2_22483619_ChIP-Seq_HELA_Human	1.01397571
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01141809
85	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.01122148
86	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00686586
87	FUS_26573619_Chip-Seq_HEK293_Human	0.99422168
88	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.99363384
89	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.99263501
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.99128766
91	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98859341
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98789599
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97813621
94	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.97719782
95	P300_27268052_Chip-Seq_Bcells_Human	0.95706169
96	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95529121
97	IGF1R_20145208_ChIP-Seq_DFB_Human	0.94948756
98	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.93881231
99	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.92948770
100	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.92529280

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.36469159
2	MP0009379_abnormal_foot_pigmentation	4.01875478
3	MP0006292_abnormal_olfactory_placode	3.16126734
4	MP0005075_abnormal_melanosome_morpholog	2.22303086
5	MP0003646_muscle_fatigue	2.20569702
6	MP0009785_altered_susceptibility_to	2.11584539
7	MP0003763_abnormal_thymus_physiology	2.04039440
8	MP0008875_abnormal_xenobiotic_pharmacok	1.99540526
9	MP0005646_abnormal_pituitary_gland	1.99005531
10	MP0002933_joint_inflammation	1.98826159
11	MP0006072_abnormal_retinal_apoptosis	1.96873229
12	MP0002102_abnormal_ear_morphology	1.96232917
13	MP0009333_abnormal_splenocyte_physiolog	1.94470599
14	MP0000372_irregular_coat_pigmentation	1.89596255
15	MP0001835_abnormal_antigen_presentation	1.83525016
16	MP0008877_abnormal_DNA_methylation	1.77758884
17	MP0001873_stomach_inflammation	1.74486048
18	MP0001905_abnormal_dopamine_level	1.73427108
19	MP0002876_abnormal_thyroid_physiology	1.73349994
20	MP0001800_abnormal_humoral_immune	1.72854302
21	MP0002163_abnormal_gland_morphology	1.69640170
22	MP0008872_abnormal_physiological_respon	1.67749568
23	MP0003878_abnormal_ear_physiology	1.66768051
24	MP0005377_hearing/vestibular/ear_phenot	1.66768051
25	MP0002148_abnormal_hypersensitivity_rea	1.64744407
26	MP0004147_increased_porphyrin_level	1.63030497
27	MP0005253_abnormal_eye_physiology	1.60301726
28	MP0006082_CNS_inflammation	1.60296933
29	MP0005551_abnormal_eye_electrophysiolog	1.59884273
30	MP0005000_abnormal_immune_tolerance	1.55840686
31	MP0002095_abnormal_skin_pigmentation	1.52311648
32	MP0002837_dystrophic_cardiac_calcinosis	1.52080373
33	MP0003011_delayed_dark_adaptation	1.51007813
34	MP0004885_abnormal_endolymph	1.50740680
35	MP0005645_abnormal_hypothalamus_physiol	1.49829651
36	MP0005389_reproductive_system_phenotype	1.47824237
37	MP0002723_abnormal_immune_serum	1.44400523
38	MP0003880_abnormal_central_pattern	1.44105345
39	MP0003866_abnormal_defecation	1.41217202
40	MP0002736_abnormal_nociception_after	1.36449591
41	MP0002638_abnormal_pupillary_reflex	1.35505899
42	MP0002420_abnormal_adaptive_immunity	1.34415961
43	MP0010386_abnormal_urinary_bladder	1.34208801
44	MP0002160_abnormal_reproductive_system	1.33208464
45	MP0008789_abnormal_olfactory_epithelium	1.32336324
46	MP0001919_abnormal_reproductive_system	1.31054384
47	MP0008058_abnormal_DNA_repair	1.30961292
48	MP0001819_abnormal_immune_cell	1.30801625
49	MP0005025_abnormal_response_to	1.30798873
50	MP0004142_abnormal_muscle_tone	1.27307162
51	MP0003787_abnormal_imprinting	1.25574808
52	MP0005084_abnormal_gallbladder_morpholo	1.23238638
53	MP0001968_abnormal_touch/_nociception	1.23077045
54	MP0003806_abnormal_nucleotide_metabolis	1.22678690
55	MP0005174_abnormal_tail_pigmentation	1.21890384
56	MP0002653_abnormal_ependyma_morphology	1.19807714
57	MP0000685_abnormal_immune_system	1.17298417
58	MP0002277_abnormal_respiratory_mucosa	1.16870120
59	MP0002452_abnormal_antigen_presenting	1.16317426
60	MP0006276_abnormal_autonomic_nervous	1.13061799
61	MP0005379_endocrine/exocrine_gland_phen	1.12143024
62	MP0005387_immune_system_phenotype	1.11656548
63	MP0001790_abnormal_immune_system	1.11656548
64	MP0006036_abnormal_mitochondrial_physio	1.09054811
65	MP0002234_abnormal_pharynx_morphology	1.08083724
66	MP0005410_abnormal_fertilization	1.04230773
67	MP0001485_abnormal_pinna_reflex	1.03689632
68	MP0000716_abnormal_immune_system	1.02973567
69	MP0003786_premature_aging	1.01907865
70	MP0002398_abnormal_bone_marrow	1.00391063
71	MP0004145_abnormal_muscle_electrophysio	0.97347575
72	MP0000703_abnormal_thymus_morphology	0.96757917
73	MP0003195_calcinosis	0.96559015
74	MP0001529_abnormal_vocalization	0.95118731
75	MP0000689_abnormal_spleen_morphology	0.93298584
76	MP0003121_genomic_imprinting	0.91571092
77	MP0002166_altered_tumor_susceptibility	0.91479092
78	MP0001727_abnormal_embryo_implantation	0.91058617
79	MP0003718_maternal_effect	0.90946281
80	MP0009764_decreased_sensitivity_to	0.90804795
81	MP0001986_abnormal_taste_sensitivity	0.88898697
82	MP0003693_abnormal_embryo_hatching	0.88485848
83	MP0002210_abnormal_sex_determination	0.83665683
84	MP0002006_tumorigenesis	0.83169745
85	MP0001845_abnormal_inflammatory_respons	0.82527206
86	MP0003186_abnormal_redox_activity	0.82156707
87	MP0009765_abnormal_xenobiotic_induced	0.81713746
88	MP0002722_abnormal_immune_system	0.81076802
89	MP0010155_abnormal_intestine_physiology	0.80795805
90	MP0002429_abnormal_blood_cell	0.80262408
91	MP0003283_abnormal_digestive_organ	0.79485023
92	MP0000631_abnormal_neuroendocrine_gland	0.79468865
93	MP0005636_abnormal_mineral_homeostasis	0.79423411
94	MP0000230_abnormal_systemic_arterial	0.77363138
95	MP0002138_abnormal_hepatobiliary_system	0.76227925
96	MP0001293_anophthalmia	0.76105102
97	MP0005195_abnormal_posterior_eye	0.76072568
98	MP0002272_abnormal_nervous_system	0.75480568
99	MP0008469_abnormal_protein_level	0.75173100
100	MP0001929_abnormal_gametogenesis	0.75007550

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.66399245
2	Mitochondrial inheritance (HP:0001427)	4.29198630
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.22895391
4	Acute encephalopathy (HP:0006846)	3.97888824
5	Progressive macrocephaly (HP:0004481)	3.84641733
6	Increased CSF lactate (HP:0002490)	3.76591313
7	3-Methylglutaconic aciduria (HP:0003535)	3.52202155
8	Hepatocellular necrosis (HP:0001404)	3.39812291
9	Aplastic anemia (HP:0001915)	3.36403944
10	IgG deficiency (HP:0004315)	3.34160827
11	Increased hepatocellular lipid droplets (HP:0006565)	3.28206372
12	Renal Fanconi syndrome (HP:0001994)	3.25503762
13	Elevated erythrocyte sedimentation rate (HP:0003565)	3.24555472
14	Molar tooth sign on MRI (HP:0002419)	3.20088886
15	Abnormality of midbrain morphology (HP:0002418)	3.20088886
16	Attenuation of retinal blood vessels (HP:0007843)	3.14446993
17	Reticulocytopenia (HP:0001896)	3.12800952
18	Cerebral edema (HP:0002181)	3.08740648
19	Optic disc pallor (HP:0000543)	3.03728973
20	Congenital stationary night blindness (HP:0007642)	3.03156860
21	Lipid accumulation in hepatocytes (HP:0006561)	3.01000878
22	Abnormality of cells of the erythroid lineage (HP:0012130)	3.00288476
23	Hepatic necrosis (HP:0002605)	2.96890281
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.93391843
25	Abnormality of macular pigmentation (HP:0008002)	2.92246651
26	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.92172156
27	Abnormal number of erythroid precursors (HP:0012131)	2.91418839
28	Increased intramyocellular lipid droplets (HP:0012240)	2.86815955
29	Constricted visual fields (HP:0001133)	2.81973821
30	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.77938287
31	Pancreatic cysts (HP:0001737)	2.66393862
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.53508224
33	Chronic bronchitis (HP:0004469)	2.52245195
34	Increased serum lactate (HP:0002151)	2.52000391
35	Hypoproteinemia (HP:0003075)	2.51422902
36	Lactic acidosis (HP:0003128)	2.49006512
37	Pancreatic fibrosis (HP:0100732)	2.48455107
38	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.47576043
39	Abolished electroretinogram (ERG) (HP:0000550)	2.47494781
40	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.46765405
41	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.46765405
42	Absent thumb (HP:0009777)	2.46384735
43	Macrocytic anemia (HP:0001972)	2.43607307
44	Increased muscle lipid content (HP:0009058)	2.36804966
45	Type I transferrin isoform profile (HP:0003642)	2.32202367
46	True hermaphroditism (HP:0010459)	2.29464437
47	Severe combined immunodeficiency (HP:0004430)	2.26083145
48	Asplenia (HP:0001746)	2.21789277
49	Lethargy (HP:0001254)	2.21694744
50	Exertional dyspnea (HP:0002875)	2.20966318
51	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.18956994
52	Pendular nystagmus (HP:0012043)	2.15886455
53	Abnormality of T cell number (HP:0011839)	2.14497779
54	Respiratory failure (HP:0002878)	2.13162877
55	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.13029652
56	Abnormality of the prostate (HP:0008775)	2.10337096
57	Stomatitis (HP:0010280)	2.07793910
58	Rhinitis (HP:0012384)	2.07354081
59	Abnormal respiratory motile cilium physiology (HP:0012261)	2.05969659
60	T lymphocytopenia (HP:0005403)	2.04024523
61	Congenital, generalized hypertrichosis (HP:0004540)	2.03604841
62	Abnormality of T cells (HP:0002843)	2.01224570
63	Nephronophthisis (HP:0000090)	2.01134325
64	Abnormality of renal resorption (HP:0011038)	2.00726360
65	Aplasia/hypoplasia of the uterus (HP:0008684)	2.00300133
66	Exercise intolerance (HP:0003546)	1.96585137
67	Respiratory difficulties (HP:0002880)	1.95714933
68	Abnormality of eosinophils (HP:0001879)	1.94585702
69	Abnormality of the renal cortex (HP:0011035)	1.91896333
70	Renal cortical cysts (HP:0000803)	1.91592661
71	Pancytopenia (HP:0001876)	1.91002110
72	Autoimmune hemolytic anemia (HP:0001890)	1.90884974
73	Microretrognathia (HP:0000308)	1.90475628
74	Reduced antithrombin III activity (HP:0001976)	1.89073030
75	Abnormal protein glycosylation (HP:0012346)	1.88117946
76	Abnormal glycosylation (HP:0012345)	1.88117946
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.88117946
78	Abnormal protein N-linked glycosylation (HP:0012347)	1.88117946
79	Leukodystrophy (HP:0002415)	1.88043985
80	Hyperglycinemia (HP:0002154)	1.85992834
81	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.85957774
82	Pallor (HP:0000980)	1.85519877
83	Increased IgM level (HP:0003496)	1.85411003
84	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.82179387
85	Absent/shortened dynein arms (HP:0200106)	1.82179387
86	Glycosuria (HP:0003076)	1.81867204
87	Abnormality of urine glucose concentration (HP:0011016)	1.81867204
88	Abnormality of alanine metabolism (HP:0010916)	1.81538142
89	Hyperalaninemia (HP:0003348)	1.81538142
90	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.81538142
91	Thyroiditis (HP:0100646)	1.80354469
92	Anencephaly (HP:0002323)	1.80296938
93	Methylmalonic acidemia (HP:0002912)	1.76840525
94	Type II lissencephaly (HP:0007260)	1.76619851
95	Hypoplasia of the uterus (HP:0000013)	1.74220200
96	Hypoalbuminemia (HP:0003073)	1.74072668
97	Abnormal albumin level (HP:0012116)	1.74072668
98	Severe visual impairment (HP:0001141)	1.73238499
99	Partial duplication of thumb phalanx (HP:0009944)	1.73201651
100	Sclerocornea (HP:0000647)	1.72772966

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.93454897
2	KDR	3.32703351
3	TESK2	3.23800203
4	VRK2	3.17647451
5	BCKDK	3.09984906
6	MAP4K2	2.61830564
7	CDK19	2.48859612
8	TLK1	2.47988818
9	NUAK1	2.46744086
10	ZAK	2.32041410
11	ADRBK2	2.17591733
12	MAP4K1	2.13699587
13	FES	2.04966209
14	KIT	1.95016651
15	STK16	1.77606605
16	MAP2K7	1.74675884
17	GRK1	1.73893639
18	BUB1	1.59993392
19	TAOK3	1.58068239
20	VRK1	1.51409213
21	WNK4	1.42255097
22	TEC	1.41218602
23	FRK	1.34415597
24	IKBKB	1.26652863
25	TIE1	1.23074230
26	LIMK1	1.22649874
27	ITK	1.19104760
28	TESK1	1.17193328
29	OXSR1	1.16533795
30	SYK	1.15389636
31	PLK4	1.15235600
32	MUSK	1.14870626
33	PINK1	1.12183292
34	PRKCQ	1.12046977
35	MST4	1.08904889
36	INSRR	1.05754917
37	MAP3K12	1.05055050
38	PRKCH	1.03328577
39	DYRK2	0.96289283
40	DAPK1	0.95170260
41	WNK3	0.95141961
42	BMPR1B	0.94986123
43	GRK6	0.93532052
44	LCK	0.92929431
45	CSK	0.90712120
46	NME2	0.90028738
47	PBK	0.88658636
48	IKBKE	0.81466982
49	CAMKK2	0.79552395
50	ADRBK1	0.76489616
51	RPS6KA5	0.76438596
52	TRIM28	0.74966383
53	MAP3K11	0.71128746
54	GRK7	0.70607216
55	NME1	0.69875943
56	GRK5	0.68631949
57	STK39	0.68087362
58	MAP3K4	0.65580450
59	TYRO3	0.64708512
60	PHKG2	0.63663643
61	PHKG1	0.63663643
62	PASK	0.63009816
63	MYLK	0.62577633
64	BTK	0.62365564
65	CSNK1G3	0.62259266
66	DAPK2	0.60670121
67	ABL2	0.56982231
68	MAP2K2	0.56905184
69	LYN	0.55918149
70	PIK3CA	0.54026258
71	LRRK2	0.53429058
72	AURKA	0.53268081
73	MAPK13	0.52171763
74	TNK2	0.51885145
75	TBK1	0.51607680
76	MAP2K6	0.50620132
77	PRKCG	0.50583933
78	CSNK1G2	0.49412284
79	OBSCN	0.49255854
80	PDK2	0.48860474
81	CDC7	0.48326963
82	MAPKAPK5	0.47007815
83	CSF1R	0.46463105
84	PLK1	0.46115471
85	DAPK3	0.45490946
86	PRKACA	0.45267192
87	PRKCA	0.44044337
88	CDK3	0.42991619
89	CSNK2A1	0.42990110
90	ATR	0.41441761
91	PRKCD	0.41305364
92	CSNK1G1	0.41163312
93	CSNK1A1	0.39427586
94	CSNK2A2	0.38906249
95	AURKB	0.37191695
96	PIM1	0.36990269
97	IGF1R	0.33472127
98	CHEK2	0.32959376
99	MAPKAPK3	0.32942177
100	PLK3	0.32625194

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.84709903
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.13259088
3	Proteasome_Homo sapiens_hsa03050	3.91447921
4	Parkinsons disease_Homo sapiens_hsa05012	3.47198350
5	RNA polymerase_Homo sapiens_hsa03020	3.02628330
6	Primary immunodeficiency_Homo sapiens_hsa05340	2.93742316
7	Huntingtons disease_Homo sapiens_hsa05016	2.30384445
8	Alzheimers disease_Homo sapiens_hsa05010	2.27998834
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.22048938
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.19650283
11	Allograft rejection_Homo sapiens_hsa05330	2.18171225
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.16212399
13	Homologous recombination_Homo sapiens_hsa03440	1.83285416
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.79610202
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.77112376
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.76200672
17	Phototransduction_Homo sapiens_hsa04744	1.74667356
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.69262015
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.63580124
20	Asthma_Homo sapiens_hsa05310	1.60184615
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.59969374
22	Protein export_Homo sapiens_hsa03060	1.53343962
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51278292
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.48228534
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.43516453
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.31223751
27	One carbon pool by folate_Homo sapiens_hsa00670	1.25811172
28	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.21582119
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.18801892
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.18407999
31	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.18093697
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16901052
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16244449
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.15429882
35	RNA degradation_Homo sapiens_hsa03018	1.14878013
36	Mismatch repair_Homo sapiens_hsa03430	1.06097927
37	Purine metabolism_Homo sapiens_hsa00230	1.04757156
38	Basal transcription factors_Homo sapiens_hsa03022	1.02600964
39	Viral myocarditis_Homo sapiens_hsa05416	0.98663174
40	Peroxisome_Homo sapiens_hsa04146	0.97960406
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93994289
42	DNA replication_Homo sapiens_hsa03030	0.91511907
43	Caffeine metabolism_Homo sapiens_hsa00232	0.91380006
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90593958
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87052526
46	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.86475574
47	Spliceosome_Homo sapiens_hsa03040	0.85624477
48	Base excision repair_Homo sapiens_hsa03410	0.85141231
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84821292
50	Propanoate metabolism_Homo sapiens_hsa00640	0.83271366
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.82725263
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.82070772
53	Olfactory transduction_Homo sapiens_hsa04740	0.79994761
54	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76393535
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75880715
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.75418825
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75116545
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73081864
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72754101
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.71453430
61	Nucleotide excision repair_Homo sapiens_hsa03420	0.71258908
62	Sulfur metabolism_Homo sapiens_hsa00920	0.70507549
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.69165263
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.68724727
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.67807376
66	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.67070724
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66735243
68	Butanoate metabolism_Homo sapiens_hsa00650	0.65397729
69	Metabolic pathways_Homo sapiens_hsa01100	0.65039215
70	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.64271834
71	Retinol metabolism_Homo sapiens_hsa00830	0.64217682
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63846842
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.62490155
74	Malaria_Homo sapiens_hsa05144	0.58614503
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56866935
76	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.54392785
77	Fatty acid elongation_Homo sapiens_hsa00062	0.54165903
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.53171826
79	RNA transport_Homo sapiens_hsa03013	0.47774615
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44157639
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43519959
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42810282
83	Folate biosynthesis_Homo sapiens_hsa00790	0.40188079
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.39959625
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.38317462
86	Nicotine addiction_Homo sapiens_hsa05033	0.33823354
87	Taste transduction_Homo sapiens_hsa04742	0.33525321
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33479941
89	Glutathione metabolism_Homo sapiens_hsa00480	0.31794595
90	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.31744185
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.28838776
92	Sulfur relay system_Homo sapiens_hsa04122	0.28330871
93	Measles_Homo sapiens_hsa05162	0.27593260
94	Non-homologous end-joining_Homo sapiens_hsa03450	0.26062374
95	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.25681261
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25138307
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.23464258
98	Leishmaniasis_Homo sapiens_hsa05140	0.22734236
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.21826249
100	Herpes simplex infection_Homo sapiens_hsa05168	0.20338071

RPL10AP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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