RPL10P14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of antigen processing and presentation of peptide antigen (GO:0002583)9.13206006
2leukocyte aggregation (GO:0070486)7.49580733
3activation of MAPKKK activity (GO:0000185)7.32763894
4viral transcription (GO:0019083)6.75562503
5translational termination (GO:0006415)6.36038273
6DNA deamination (GO:0045006)6.04302640
7ribosomal small subunit assembly (GO:0000028)5.91645897
8behavioral response to nicotine (GO:0035095)5.72065697
9ribosomal small subunit biogenesis (GO:0042274)5.27665143
10translational elongation (GO:0006414)5.23679016
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.15980200
12protein targeting to ER (GO:0045047)5.13586279
13cotranslational protein targeting to membrane (GO:0006613)5.06184405
14positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.91976771
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.88549367
16positive regulation of defense response to virus by host (GO:0002230)4.84471544
17viral life cycle (GO:0019058)4.79804251
18protein localization to endoplasmic reticulum (GO:0070972)4.78915103
19cellular protein complex disassembly (GO:0043624)4.73395032
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.60917142
21rRNA transcription (GO:0009303)4.55003010
22chaperone-mediated protein transport (GO:0072321)4.48134953
23cellular response to dexamethasone stimulus (GO:0071549)4.24789885
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.18270860
25maturation of SSU-rRNA (GO:0030490)4.15723543
26glycoprotein catabolic process (GO:0006516)4.02737437
27metallo-sulfur cluster assembly (GO:0031163)3.99562181
28iron-sulfur cluster assembly (GO:0016226)3.99562181
29response to dexamethasone (GO:0071548)3.95023780
30nonmotile primary cilium assembly (GO:0035058)3.91434746
31protein complex disassembly (GO:0043241)3.90814020
32negative regulation of T cell differentiation in thymus (GO:0033085)3.88336204
33translational initiation (GO:0006413)3.85338832
34cellular response to exogenous dsRNA (GO:0071360)3.83677266
35activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.82990335
36regulation of antigen processing and presentation (GO:0002577)3.81302054
37positive regulation of signal transduction by p53 class mediator (GO:1901798)3.68953894
38macromolecular complex disassembly (GO:0032984)3.59170920
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54970668
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.54970668
41NADH dehydrogenase complex assembly (GO:0010257)3.54970668
42cytidine metabolic process (GO:0046087)3.54834954
43cytidine catabolic process (GO:0006216)3.54834954
44cytidine deamination (GO:0009972)3.54834954
45regulation of regulatory T cell differentiation (GO:0045589)3.52427545
46erythrocyte maturation (GO:0043249)3.47497010
47preassembly of GPI anchor in ER membrane (GO:0016254)3.45585459
48protein targeting to membrane (GO:0006612)3.37803614
49water-soluble vitamin biosynthetic process (GO:0042364)3.37444861
50pyrimidine nucleobase catabolic process (GO:0006208)3.37409321
51resolution of meiotic recombination intermediates (GO:0000712)3.32755489
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.29043902
53cilium movement (GO:0003341)3.22172900
54protein complex biogenesis (GO:0070271)3.16117814
55ATP synthesis coupled proton transport (GO:0015986)3.13292798
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.13292798
57negative regulation by host of viral transcription (GO:0043922)3.09679185
58nuclear-transcribed mRNA catabolic process (GO:0000956)3.07838983
59mast cell activation involved in immune response (GO:0002279)3.06132994
60mast cell degranulation (GO:0043303)3.06132994
61regulation of defense response to virus by host (GO:0050691)2.99199516
62head development (GO:0060322)2.96547829
63lysosome localization (GO:0032418)2.96131477
64translation (GO:0006412)2.95321947
65negative regulation of cell cycle arrest (GO:0071157)2.95081315
66pyrimidine ribonucleoside catabolic process (GO:0046133)2.94893991
67mRNA catabolic process (GO:0006402)2.94869430
68mast cell activation (GO:0045576)2.90266211
69SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.87169089
70endoderm formation (GO:0001706)2.82203136
71axoneme assembly (GO:0035082)2.80512859
72synaptic transmission, cholinergic (GO:0007271)2.80465848
73peptidyl-histidine modification (GO:0018202)2.77947500
74mechanosensory behavior (GO:0007638)2.75594469
75mitochondrial respiratory chain complex assembly (GO:0033108)2.75404195
76lymphocyte chemotaxis (GO:0048247)2.73750947
77induction of positive chemotaxis (GO:0050930)2.70618368
78epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66476478
79T cell migration (GO:0072678)2.66420260
80nucleobase catabolic process (GO:0046113)2.66365021
81male meiosis I (GO:0007141)2.65852232
82histone H4-K12 acetylation (GO:0043983)2.65177363
83positive regulation of muscle cell apoptotic process (GO:0010661)2.63555100
84negative regulation of macrophage differentiation (GO:0045650)2.63432960
85ribosomal large subunit biogenesis (GO:0042273)2.61969810
86negative regulation of response to biotic stimulus (GO:0002832)2.61936516
87meiotic chromosome segregation (GO:0045132)2.60919657
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.56816393
89RNA catabolic process (GO:0006401)2.55766639
90positive regulation of protein homooligomerization (GO:0032464)2.53583849
91regulation of interleukin-12 biosynthetic process (GO:0045075)2.49209058
92response to xenobiotic stimulus (GO:0009410)2.49153451
93positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.49067796
94pseudouridine synthesis (GO:0001522)2.48794033
95regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.48557005
96protein targeting to mitochondrion (GO:0006626)2.47641386
97nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.44380296
98piRNA metabolic process (GO:0034587)2.43729694
99indolalkylamine metabolic process (GO:0006586)2.43540433
100intracellular protein transmembrane import (GO:0044743)2.42619343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.15478271
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.43079697
3EZH2_22144423_ChIP-Seq_EOC_Human3.66121642
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.57898206
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.31101906
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.28821522
7ZNF274_21170338_ChIP-Seq_K562_Hela2.25575715
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12876528
9VDR_22108803_ChIP-Seq_LS180_Human2.02540193
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.01740268
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01609001
12EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.85329403
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83343664
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.78839015
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74300926
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.74197867
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68918464
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.64586858
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.64392730
20IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63628143
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63430103
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55328312
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49237115
24RNF2_27304074_Chip-Seq_NSC_Mouse1.49207744
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.47750950
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47576375
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39561456
28MYC_19829295_ChIP-Seq_ESCs_Human1.37737202
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37500951
30EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.37438805
31E2F1_20622854_ChIP-Seq_HELA_Human1.37059652
32TAF2_19829295_ChIP-Seq_ESCs_Human1.35623725
33ERA_21632823_ChIP-Seq_H3396_Human1.34793016
34CIITA_25753668_ChIP-Seq_RAJI_Human1.31351712
35BCL6_27268052_Chip-Seq_Bcells_Human1.28743573
36TP53_22573176_ChIP-Seq_HFKS_Human1.27626283
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27045750
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26143745
39NANOG_20526341_ChIP-Seq_ESCs_Human1.24542786
40STAT1_20625510_ChIP-Seq_HELA_Human1.24223881
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22683576
42RUNX_20019798_ChIP-Seq_JUKART_Human1.21343172
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21236144
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19214399
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18247935
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.17987969
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17987969
48P300_27268052_Chip-Seq_Bcells_Human1.17304237
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.17148469
50RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.15594546
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15483049
52NCOR_22424771_ChIP-Seq_293T_Human1.15391658
53YY1_22570637_ChIP-Seq_MALME-3M_Human1.15325724
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15310064
55FOXH1_21741376_ChIP-Seq_ESCs_Human1.14666332
56FUS_26573619_Chip-Seq_HEK293_Human1.14490789
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13324103
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13324103
59GABP_17652178_ChIP-ChIP_JURKAT_Human1.12419762
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09626804
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09162788
62CTCF_20526341_ChIP-Seq_ESCs_Human1.09102378
63AR_20517297_ChIP-Seq_VCAP_Human1.08963104
64RAC3_21632823_ChIP-Seq_H3396_Human1.08152973
65IRF1_19129219_ChIP-ChIP_H3396_Human1.08114619
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06886105
67DROSHA_22980978_ChIP-Seq_HELA_Human1.03193432
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02911548
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02903719
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02317039
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02022172
72TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01653879
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01369839
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00098332
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00013578
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99776691
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98662719
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97390258
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97221545
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97138804
81RNF2_27304074_Chip-Seq_ESCs_Mouse0.97073401
82REST_21632747_ChIP-Seq_MESCs_Mouse0.96917067
83SOX2_21211035_ChIP-Seq_LN229_Human0.96298255
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96188960
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95757328
86GBX2_23144817_ChIP-Seq_PC3_Human0.94742702
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94352002
88GATA3_26560356_Chip-Seq_TH2_Human0.94133002
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93220579
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.92948900
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91545896
92SPI1_20517297_ChIP-Seq_HL60_Human0.91322575
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90421833
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90259663
95EWS_26573619_Chip-Seq_HEK293_Human0.90185155
96SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89626668
97SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89113890
98VDR_23849224_ChIP-Seq_CD4+_Human0.88947278
99TP53_20018659_ChIP-ChIP_R1E_Mouse0.87544244
100RBPJ_21746931_ChIP-Seq_IB4_Human0.87133990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology5.37482718
2MP0009379_abnormal_foot_pigmentation5.19410470
3MP0008789_abnormal_olfactory_epithelium4.03807828
4MP0006292_abnormal_olfactory_placode3.62873699
5MP0005499_abnormal_olfactory_system3.08937665
6MP0005394_taste/olfaction_phenotype3.08937665
7MP0005671_abnormal_response_to2.68408078
8MP0000750_abnormal_muscle_regeneration2.67808097
9MP0003763_abnormal_thymus_physiology2.59890229
10MP0003786_premature_aging2.56202543
11MP0003646_muscle_fatigue2.41505550
12MP0004147_increased_porphyrin_level2.33102649
13MP0009333_abnormal_splenocyte_physiolog2.14055653
14MP0009384_cardiac_valve_regurgitation1.86775329
15MP0002938_white_spotting1.83385870
16MP0002876_abnormal_thyroid_physiology1.76901349
17MP0010386_abnormal_urinary_bladder1.71744966
18MP0001800_abnormal_humoral_immune1.71577758
19MP0002933_joint_inflammation1.70944577
20MP0001835_abnormal_antigen_presentation1.67314188
21MP0005551_abnormal_eye_electrophysiolog1.63925935
22MP0004145_abnormal_muscle_electrophysio1.62985878
23MP0000013_abnormal_adipose_tissue1.55769119
24MP0002148_abnormal_hypersensitivity_rea1.53980298
25MP0002102_abnormal_ear_morphology1.53809311
26MP0002163_abnormal_gland_morphology1.53532440
27MP0001986_abnormal_taste_sensitivity1.49470228
28MP0002638_abnormal_pupillary_reflex1.47518587
29MP0003436_decreased_susceptibility_to1.46936347
30MP0001790_abnormal_immune_system1.43955788
31MP0005387_immune_system_phenotype1.43955788
32MP0004947_skin_inflammation1.42515906
33MP0006072_abnormal_retinal_apoptosis1.42162170
34MP0008872_abnormal_physiological_respon1.41053468
35MP0002723_abnormal_immune_serum1.36425967
36MP0001879_abnormal_lymphatic_vessel1.36017659
37MP0008775_abnormal_heart_ventricle1.34836131
38MP0005084_abnormal_gallbladder_morpholo1.28844159
39MP0009785_altered_susceptibility_to1.26045839
40MP0005000_abnormal_immune_tolerance1.23916404
41MP0002420_abnormal_adaptive_immunity1.16808435
42MP0002837_dystrophic_cardiac_calcinosis1.15711784
43MP0009764_decreased_sensitivity_to1.13395480
44MP0001819_abnormal_immune_cell1.13361000
45MP0001293_anophthalmia1.07670873
46MP0004142_abnormal_muscle_tone1.07604089
47MP0002006_tumorigenesis1.05606369
48MP0003567_abnormal_fetal_cardiomyocyte1.03858949
49MP0005379_endocrine/exocrine_gland_phen0.99239490
50MP0001968_abnormal_touch/_nociception0.98950579
51MP0005670_abnormal_white_adipose0.98794795
52MP0009745_abnormal_behavioral_response0.98549628
53MP0002452_abnormal_antigen_presenting0.98339557
54MP0000631_abnormal_neuroendocrine_gland0.98328326
55MP0005646_abnormal_pituitary_gland0.98080303
56MP0001919_abnormal_reproductive_system0.92768426
57MP0002067_abnormal_sensory_capabilities0.88571770
58MP0000685_abnormal_immune_system0.86516858
59MP0006276_abnormal_autonomic_nervous0.86516482
60MP0005083_abnormal_biliary_tract0.83848499
61MP0001853_heart_inflammation0.83668625
62MP0001348_abnormal_lacrimal_gland0.83592842
63MP0006036_abnormal_mitochondrial_physio0.83329907
64MP0008995_early_reproductive_senescence0.82958270
65MP0003011_delayed_dark_adaptation0.82206475
66MP0003137_abnormal_impulse_conducting0.81255090
67MP0003879_abnormal_hair_cell0.81138568
68MP0005025_abnormal_response_to0.79826010
69MP0005389_reproductive_system_phenotype0.79020616
70MP0005410_abnormal_fertilization0.78881675
71MP0002277_abnormal_respiratory_mucosa0.78668298
72MP0005377_hearing/vestibular/ear_phenot0.78363166
73MP0003878_abnormal_ear_physiology0.78363166
74MP0000372_irregular_coat_pigmentation0.77862904
75MP0001486_abnormal_startle_reflex0.76944195
76MP0001765_abnormal_ion_homeostasis0.76411747
77MP0002166_altered_tumor_susceptibility0.76076781
78MP0002736_abnormal_nociception_after0.75139993
79MP0001873_stomach_inflammation0.75081190
80MP0005195_abnormal_posterior_eye0.73846672
81MP0002735_abnormal_chemical_nociception0.73584662
82MP0004742_abnormal_vestibular_system0.73356119
83MP0003724_increased_susceptibility_to0.72876336
84MP0000343_altered_response_to0.71858756
85MP0001851_eye_inflammation0.69241617
86MP0000858_altered_metastatic_potential0.69011376
87MP0003385_abnormal_body_wall0.68632936
88MP0004885_abnormal_endolymph0.68481526
89MP0009765_abnormal_xenobiotic_induced0.68042662
90MP0008770_decreased_survivor_rate0.67077479
91MP0000049_abnormal_middle_ear0.66937129
92MP0002272_abnormal_nervous_system0.66710321
93MP0000762_abnormal_tongue_morphology0.65965351
94MP0000689_abnormal_spleen_morphology0.65409051
95MP0003279_aneurysm0.64725678
96MP0008877_abnormal_DNA_methylation0.62706994
97MP0001845_abnormal_inflammatory_respons0.62171401
98MP0009046_muscle_twitch0.61871662
99MP0003638_abnormal_response/metabolism_0.61724801
100MP0000716_abnormal_immune_system0.61663795

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)7.37688124
2Retinal atrophy (HP:0001105)7.11816985
3Type II lissencephaly (HP:0007260)7.00697361
4Hypoplasia of the pons (HP:0012110)5.39476489
5Retinal dysplasia (HP:0007973)5.20382027
6Abnormality of the pons (HP:0007361)4.85790178
7Decreased electroretinogram (ERG) amplitude (HP:0000654)4.78742130
8Abolished electroretinogram (ERG) (HP:0000550)4.26161770
9Aplasia/Hypoplasia affecting the retina (HP:0008061)4.07909613
10Abnormal ciliary motility (HP:0012262)4.05608974
11IgG deficiency (HP:0004315)3.94223609
12Fatigue (HP:0012378)3.91612308
13Buphthalmos (HP:0000557)3.88362182
14Increased muscle lipid content (HP:0009058)3.86038134
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.67311453
16Rectal prolapse (HP:0002035)3.66313138
17Difficulty climbing stairs (HP:0003551)3.55730167
18Abnormal respiratory motile cilium morphology (HP:0005938)3.51907835
19Abnormal respiratory epithelium morphology (HP:0012253)3.51907835
20Increased intramyocellular lipid droplets (HP:0012240)3.48626897
21Lipid accumulation in hepatocytes (HP:0006561)3.41779035
22Stomatitis (HP:0010280)3.38129553
23Abnormal respiratory motile cilium physiology (HP:0012261)3.31351787
24Severe muscular hypotonia (HP:0006829)3.30972133
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.20192686
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.20192686
27Pallor (HP:0000980)3.06973232
28Panhypogammaglobulinemia (HP:0003139)3.01948657
29Chronic sinusitis (HP:0011109)2.84432953
30Tubular atrophy (HP:0000092)2.83427014
31Congenital, generalized hypertrichosis (HP:0004540)2.79245877
32Abnormality of cells of the erythroid lineage (HP:0012130)2.75593068
33Abnormal pupillary function (HP:0007686)2.71678098
34Lissencephaly (HP:0001339)2.65719027
35Aplasia/Hypoplasia of the spleen (HP:0010451)2.63245941
36Papilledema (HP:0001085)2.62692558
37Increased hepatocellular lipid droplets (HP:0006565)2.56127563
38Rhinitis (HP:0012384)2.53970876
39Asplenia (HP:0001746)2.53165710
40Pancreatic cysts (HP:0001737)2.50563369
41Abnormal number of erythroid precursors (HP:0012131)2.50192615
42Meningocele (HP:0002435)2.47296500
43Abnormal drinking behavior (HP:0030082)2.43565775
44Polydipsia (HP:0001959)2.43565775
45Nephronophthisis (HP:0000090)2.41185111
46Megalocornea (HP:0000485)2.30584437
47Pachygyria (HP:0001302)2.28826800
48Elevated erythrocyte sedimentation rate (HP:0003565)2.28765888
49Renal Fanconi syndrome (HP:0001994)2.28065624
50Hypoplasia of the brainstem (HP:0002365)2.22624199
51Aplasia/Hypoplasia of the brainstem (HP:0007362)2.22624199
52Abnormality of midbrain morphology (HP:0002418)2.21194827
53Molar tooth sign on MRI (HP:0002419)2.21194827
54Increased IgM level (HP:0003496)2.17993783
55Congenital stationary night blindness (HP:0007642)2.17289135
56Erythroderma (HP:0001019)2.14827954
57Concave nail (HP:0001598)2.13432077
58Macrocytic anemia (HP:0001972)2.13394317
59B lymphocytopenia (HP:0010976)2.11480388
60T lymphocytopenia (HP:0005403)2.11248564
61Intellectual disability, profound (HP:0002187)2.10181538
62Congenital glaucoma (HP:0001087)2.08946990
63Colon cancer (HP:0003003)2.03574120
64Abnormality of the renal medulla (HP:0100957)2.03359377
65Abnormality of the renal cortex (HP:0011035)2.02279343
66Mitochondrial inheritance (HP:0001427)2.01919749
67Severe combined immunodeficiency (HP:0004430)2.01474125
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99218455
69Maternal diabetes (HP:0009800)1.99022260
70Hypoplasia of the uterus (HP:0000013)1.96178834
71Abnormal delayed hypersensitivity skin test (HP:0002963)1.95740011
72Reticulocytopenia (HP:0001896)1.94866299
73Hyperglycinemia (HP:0002154)1.93031563
74Abnormality of the vitreous humor (HP:0004327)1.92629175
75Generalized muscle weakness (HP:0003324)1.92276652
76Acute necrotizing encephalopathy (HP:0006965)1.91206687
77Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.88079359
78Abnormality of B cell number (HP:0010975)1.87286755
79Encephalitis (HP:0002383)1.86731600
80Spontaneous hematomas (HP:0007420)1.85922072
81Abnormality of DNA repair (HP:0003254)1.85212826
82Brittle hair (HP:0002299)1.85174542
83Bronchiectasis (HP:0002110)1.85145605
84Aplasia/hypoplasia of the uterus (HP:0008684)1.83398163
85Mesangial abnormality (HP:0001966)1.82760954
863-Methylglutaconic aciduria (HP:0003535)1.82424132
87Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82280001
88Non-midline cleft lip (HP:0100335)1.81857521
89Abnormality of T cell number (HP:0011839)1.81364265
90Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.80869136
91Severe global developmental delay (HP:0011344)1.80574136
92Holoprosencephaly (HP:0001360)1.80360359
93Decreased subcutaneous fat (HP:0001002)1.78241188
94Paralysis (HP:0003470)1.77361163
95IgM deficiency (HP:0002850)1.75209123
96Generalized hypotonia (HP:0001290)1.75132703
97Hypoplasia of the thymus (HP:0000778)1.74563192
98Fragile nails (HP:0001808)1.74214220
99Exertional dyspnea (HP:0002875)1.73835175
100Acute encephalopathy (HP:0006846)1.71457182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK35.71263680
2MAP2K25.34224573
3STK104.84165903
4TXK3.63976309
5WNK43.05312643
6TIE12.70349603
7MAPK152.38803887
8ADRBK22.37370470
9STK112.34050251
10PIM12.30719258
11MAP4K12.21371070
12STK392.19995102
13TSSK62.19670827
14MAP4K21.87841798
15TNK21.83463994
16NEK91.73323358
17DYRK1A1.71400613
18MAP2K11.64503319
19DYRK21.49963000
20OXSR11.46092404
21BUB11.38270858
22GRK11.34160758
23TEC1.20778325
24MAP2K61.19915588
25PIK3CA1.13831749
26RPS6KA51.10576024
27PRKCQ1.08659145
28PINK11.07369368
29NLK1.04908808
30KDR1.04245672
31MAP3K41.01310323
32PTK2B0.99902695
33FRK0.95455079
34TLK10.94919722
35INSRR0.91933662
36LMTK20.90675225
37STK38L0.83670754
38BTK0.82627689
39ITK0.80567689
40IKBKE0.79857477
41EPHB20.74822559
42DAPK20.74732503
43BMPR1B0.74613833
44ERN10.74106732
45CAMKK20.71572355
46IKBKB0.70482003
47OBSCN0.68994940
48LCK0.66507755
49ZAK0.63562389
50SYK0.61713702
51RPS6KA60.60978603
52EIF2AK10.59963267
53ADRBK10.59565985
54NME20.57958385
55MAPK130.56115861
56WNK30.56048439
57LRRK20.55761460
58MKNK20.54401076
59LYN0.53773600
60ABL10.52913265
61PRKCH0.52825066
62STK160.51168970
63PRKACA0.50797228
64BCKDK0.50428288
65CAMK10.49337276
66MUSK0.48427285
67WNK10.47148856
68CAMK2A0.44377487
69MATK0.44047292
70CSNK1G30.43225153
71GRK60.42955127
72PRKCA0.42390272
73PRKCG0.42318053
74TAOK30.41836502
75GRK70.41556146
76CDK190.40562383
77CSF1R0.40511548
78ERBB20.39803391
79MAPK30.38879233
80CSNK2A20.38221385
81DYRK1B0.38106626
82MAP3K110.37717347
83PAK30.36014837
84PRKCZ0.35378375
85CSNK2A10.34754931
86MAP3K30.33993408
87FES0.30895955
88CSNK1G20.28882437
89TBK10.28422774
90CSNK1A1L0.28157688
91CSK0.27557794
92PIK3CG0.26293208
93MINK10.25800537
94PRKACG0.25305718
95NEK10.24405035
96MAPK140.24400973
97RPS6KL10.24208910
98RPS6KC10.24208910
99CSNK1A10.23901099
100GSK3A0.23700901

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.92738934
2Asthma_Homo sapiens_hsa053104.55112102
3Allograft rejection_Homo sapiens_hsa053304.17487927
4Autoimmune thyroid disease_Homo sapiens_hsa053204.14322403
5Graft-versus-host disease_Homo sapiens_hsa053323.97595398
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.38710240
7Type I diabetes mellitus_Homo sapiens_hsa049403.13363917
8Primary immunodeficiency_Homo sapiens_hsa053403.09530224
9Viral myocarditis_Homo sapiens_hsa054162.59723470
10Antigen processing and presentation_Homo sapiens_hsa046122.27432592
11Oxidative phosphorylation_Homo sapiens_hsa001902.17008783
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14503083
13Parkinsons disease_Homo sapiens_hsa050121.95352302
14Rheumatoid arthritis_Homo sapiens_hsa053231.94950310
15Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.84259934
16Sulfur relay system_Homo sapiens_hsa041221.78195999
17Leishmaniasis_Homo sapiens_hsa051401.69509674
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63195670
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59870783
20Staphylococcus aureus infection_Homo sapiens_hsa051501.59261926
21Cardiac muscle contraction_Homo sapiens_hsa042601.44796764
22Hematopoietic cell lineage_Homo sapiens_hsa046401.38708440
23Alzheimers disease_Homo sapiens_hsa050101.37934076
24Toxoplasmosis_Homo sapiens_hsa051451.37100451
25RNA polymerase_Homo sapiens_hsa030201.35444290
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33283574
27Huntingtons disease_Homo sapiens_hsa050161.29513967
28Phototransduction_Homo sapiens_hsa047441.28617517
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.23019798
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18387596
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16359530
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13482094
33Linoleic acid metabolism_Homo sapiens_hsa005911.13222442
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03573204
35Systemic lupus erythematosus_Homo sapiens_hsa053220.96381743
36Regulation of autophagy_Homo sapiens_hsa041400.94902379
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91256550
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90884566
39Nitrogen metabolism_Homo sapiens_hsa009100.86555696
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86085873
41Arachidonic acid metabolism_Homo sapiens_hsa005900.83521555
42Olfactory transduction_Homo sapiens_hsa047400.81455210
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69061493
44Nicotine addiction_Homo sapiens_hsa050330.62543485
45Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61729284
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.59104819
47Homologous recombination_Homo sapiens_hsa034400.58295529
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55418228
49Ovarian steroidogenesis_Homo sapiens_hsa049130.55367904
50Caffeine metabolism_Homo sapiens_hsa002320.51396851
51TNF signaling pathway_Homo sapiens_hsa046680.50191599
52Insulin secretion_Homo sapiens_hsa049110.49675256
53Tryptophan metabolism_Homo sapiens_hsa003800.45942669
54Bile secretion_Homo sapiens_hsa049760.41635591
55Ether lipid metabolism_Homo sapiens_hsa005650.40055861
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39332702
57Influenza A_Homo sapiens_hsa051640.38889409
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38304908
59T cell receptor signaling pathway_Homo sapiens_hsa046600.37336704
60Pyrimidine metabolism_Homo sapiens_hsa002400.37170292
61Morphine addiction_Homo sapiens_hsa050320.36890698
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.36303942
63Fat digestion and absorption_Homo sapiens_hsa049750.35815266
64Proteasome_Homo sapiens_hsa030500.35813691
65Basal transcription factors_Homo sapiens_hsa030220.35785018
66Fanconi anemia pathway_Homo sapiens_hsa034600.35533348
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35256774
68Chemical carcinogenesis_Homo sapiens_hsa052040.35030028
69Phagosome_Homo sapiens_hsa041450.33828235
70Propanoate metabolism_Homo sapiens_hsa006400.33795862
71Herpes simplex infection_Homo sapiens_hsa051680.33310069
72Tuberculosis_Homo sapiens_hsa051520.31722548
73Salivary secretion_Homo sapiens_hsa049700.30968599
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30658069
75Retinol metabolism_Homo sapiens_hsa008300.30071832
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28660310
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28371716
78Serotonergic synapse_Homo sapiens_hsa047260.27564792
79p53 signaling pathway_Homo sapiens_hsa041150.27513757
80Vitamin digestion and absorption_Homo sapiens_hsa049770.25011810
81Cholinergic synapse_Homo sapiens_hsa047250.24663196
82B cell receptor signaling pathway_Homo sapiens_hsa046620.24245290
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23821791
84Taste transduction_Homo sapiens_hsa047420.23762619
85African trypanosomiasis_Homo sapiens_hsa051430.23302944
86Mineral absorption_Homo sapiens_hsa049780.23031315
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22776973
88Chemokine signaling pathway_Homo sapiens_hsa040620.22735179
89Purine metabolism_Homo sapiens_hsa002300.22070813
90GABAergic synapse_Homo sapiens_hsa047270.19055005
91Collecting duct acid secretion_Homo sapiens_hsa049660.19036992
92Circadian entrainment_Homo sapiens_hsa047130.18725328
93Legionellosis_Homo sapiens_hsa051340.18204630
94cAMP signaling pathway_Homo sapiens_hsa040240.17802195
95Gastric acid secretion_Homo sapiens_hsa049710.16202973
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15633351
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15063594
98Epstein-Barr virus infection_Homo sapiens_hsa051690.14728285
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.13643456
100MAPK signaling pathway_Homo sapiens_hsa040100.12358568

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