ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.23608150
2	ribosomal small subunit assembly (GO:0000028)	6.19886995
3	viral transcription (GO:0019083)	5.99951932
4	translational termination (GO:0006415)	5.74864595
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.58075806
6	translational elongation (GO:0006414)	5.18781002
7	cytidine deamination (GO:0009972)	5.16067939
8	cytidine metabolic process (GO:0046087)	5.16067939
9	cytidine catabolic process (GO:0006216)	5.16067939
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.98863680
11	protein targeting to ER (GO:0045047)	4.91961765
12	cotranslational protein targeting to membrane (GO:0006613)	4.91094842
13	ATP synthesis coupled proton transport (GO:0015986)	4.84035954
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.84035954
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.68086690
16	protein localization to endoplasmic reticulum (GO:0070972)	4.67710603
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.51498877
18	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.51079723
19	viral life cycle (GO:0019058)	4.32473643
20	cellular protein complex disassembly (GO:0043624)	4.28548335
21	behavioral response to nicotine (GO:0035095)	4.26169169
22	maturation of SSU-rRNA (GO:0030490)	4.22905703
23	ribosomal small subunit biogenesis (GO:0042274)	4.16884868
24	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.07154072
25	protein neddylation (GO:0045116)	4.06154653
26	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.02533446
27	protein complex biogenesis (GO:0070271)	3.88860647
28	translational initiation (GO:0006413)	3.78695726
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.77088418
30	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.77088418
31	electron transport chain (GO:0022900)	3.76049348
32	respiratory electron transport chain (GO:0022904)	3.75424090
33	protein complex disassembly (GO:0043241)	3.52264515
34	chaperone-mediated protein transport (GO:0072321)	3.51015190
35	mitochondrial respiratory chain complex assembly (GO:0033108)	3.49493764
36	translation (GO:0006412)	3.47951274
37	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.42615100
38	macromolecular complex disassembly (GO:0032984)	3.35958790
39	water-soluble vitamin biosynthetic process (GO:0042364)	3.32399097
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.28053210
41	NADH dehydrogenase complex assembly (GO:0010257)	3.28053210
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.28053210
43	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.27897725
44	regulation of activation of Janus kinase activity (GO:0010533)	3.20716768
45	protein targeting to membrane (GO:0006612)	3.17445304
46	sequestering of actin monomers (GO:0042989)	3.10135737
47	hydrogen ion transmembrane transport (GO:1902600)	3.08875875
48	adaptation of signaling pathway (GO:0023058)	2.96865404
49	cytochrome complex assembly (GO:0017004)	2.96097233
50	ribosomal large subunit biogenesis (GO:0042273)	2.94643306
51	ATP biosynthetic process (GO:0006754)	2.94000933
52	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.93781290
53	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.93347083
54	platelet dense granule organization (GO:0060155)	2.93106438
55	negative regulation of mast cell activation (GO:0033004)	2.92227714
56	respiratory chain complex IV assembly (GO:0008535)	2.91949241
57	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.91395061
58	pyrimidine nucleotide catabolic process (GO:0006244)	2.89678508
59	proton transport (GO:0015992)	2.88789759
60	positive regulation of defense response to virus by host (GO:0002230)	2.85991456
61	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.84626215
62	hydrogen transport (GO:0006818)	2.82694300
63	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.81243492
64	pyrimidine nucleoside catabolic process (GO:0046135)	2.77587052
65	preassembly of GPI anchor in ER membrane (GO:0016254)	2.76282329
66	mRNA catabolic process (GO:0006402)	2.75886856
67	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.72661696
68	positive thymic T cell selection (GO:0045059)	2.72288889
69	positive regulation of calcium-mediated signaling (GO:0050850)	2.72155828
70	positive T cell selection (GO:0043368)	2.71458140
71	negative T cell selection (GO:0043383)	2.70802423
72	nucleotide salvage (GO:0043173)	2.70186909
73	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.66470851
74	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.65223896
75	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.63829454
76	metallo-sulfur cluster assembly (GO:0031163)	2.62018049
77	iron-sulfur cluster assembly (GO:0016226)	2.62018049
78	indolalkylamine metabolic process (GO:0006586)	2.61216781
79	response to interferon-beta (GO:0035456)	2.55080292
80	GTP biosynthetic process (GO:0006183)	2.54939610
81	cellular component biogenesis (GO:0044085)	2.54831321
82	GPI anchor metabolic process (GO:0006505)	2.53299784
83	CTP metabolic process (GO:0046036)	2.52121003
84	CTP biosynthetic process (GO:0006241)	2.52121003
85	RNA catabolic process (GO:0006401)	2.49522036
86	pyrimidine-containing compound catabolic process (GO:0072529)	2.47849223
87	regulation of regulatory T cell differentiation (GO:0045589)	2.47644445
88	S-adenosylmethionine metabolic process (GO:0046500)	2.47494372
89	DNA dealkylation (GO:0035510)	2.45859631
90	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.45779980
91	response to pheromone (GO:0019236)	2.43043468
92	cellular response to interferon-beta (GO:0035458)	2.42446666
93	cellular ketone body metabolic process (GO:0046950)	2.42263404
94	positive regulation of T cell apoptotic process (GO:0070234)	2.42203682
95	detection of light stimulus involved in visual perception (GO:0050908)	2.41447281
96	detection of light stimulus involved in sensory perception (GO:0050962)	2.41447281
97	deoxyribonucleotide catabolic process (GO:0009264)	2.41107869
98	base-excision repair, AP site formation (GO:0006285)	2.40873070
99	kynurenine metabolic process (GO:0070189)	2.36664140
100	regulation of isotype switching to IgG isotypes (GO:0048302)	2.33861428

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.07487027
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.72032380
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.25635517
4	VDR_22108803_ChIP-Seq_LS180_Human	2.68372793
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.64481872
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.64332353
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.55731853
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.50657282
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.45876430
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.43175105
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.16538307
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.15104264
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.09347538
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.05665614
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.03205232
16	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.02090271
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.98431954
18	VDR_23849224_ChIP-Seq_CD4+_Human	1.93289128
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.89717985
20	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.86405436
21	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.82577030
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.78737131
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.74353541
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.73008490
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71150270
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.66393000
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57746001
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.57106149
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54877343
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50667792
31	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.49949881
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.48692243
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.37970365
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.36427940
35	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.35928426
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35207538
37	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34090378
38	NANOG_20526341_ChIP-Seq_ESCs_Human	1.32150130
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32061321
40	AR_20517297_ChIP-Seq_VCAP_Human	1.30180799
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28064696
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.27968539
43	ERA_21632823_ChIP-Seq_H3396_Human	1.27302501
44	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27257046
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.27000137
46	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.26535392
47	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.25342769
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.25102457
49	RUNX_20019798_ChIP-Seq_JUKART_Human	1.24307937
50	TAF2_19829295_ChIP-Seq_ESCs_Human	1.23107729
51	NCOR_22424771_ChIP-Seq_293T_Human	1.22959501
52	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.22445285
53	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22163511
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.20340312
55	EWS_26573619_Chip-Seq_HEK293_Human	1.19659706
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18845518
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18845518
58	GATA3_26560356_Chip-Seq_TH2_Human	1.18569070
59	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.18527241
60	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.17736054
61	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.17526851
62	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.16931773
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15009543
64	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.14113223
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13909218
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13909218
67	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.13673695
68	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.12951174
69	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12890241
70	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.11965250
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10806384
72	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.10061911
73	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09414153
74	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09235236
75	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.06581909
76	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.04641975
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.04241019
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03362510
79	REST_21632747_ChIP-Seq_MESCs_Mouse	1.03050365
80	CBP_20019798_ChIP-Seq_JUKART_Human	1.01775538
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01775538
82	P300_19829295_ChIP-Seq_ESCs_Human	1.01304139
83	TAF15_26573619_Chip-Seq_HEK293_Human	1.00492021
84	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.00285551
85	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00172201
86	BCL6_27268052_Chip-Seq_Bcells_Human	0.99756540
87	GBX2_23144817_ChIP-Seq_PC3_Human	0.98810809
88	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97613874
89	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97323683
90	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.96985087
91	BCAT_22108803_ChIP-Seq_LS180_Human	0.96679262
92	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.95940047
93	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95551764
94	MYB_26560356_Chip-Seq_TH2_Human	0.93017918
95	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.92697529
96	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.91809431
97	CTCF_20526341_ChIP-Seq_ESCs_Human	0.91186795
98	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.91011789
99	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90606371
100	RAC3_21632823_ChIP-Seq_H3396_Human	0.89638480

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.54085050
2	MP0005671_abnormal_response_to	3.64921920
3	MP0003646_muscle_fatigue	3.44196512
4	MP0006292_abnormal_olfactory_placode	3.05400069
5	MP0005645_abnormal_hypothalamus_physiol	2.30926587
6	MP0008877_abnormal_DNA_methylation	2.18273435
7	MP0002102_abnormal_ear_morphology	2.13327542
8	MP0002163_abnormal_gland_morphology	2.04700054
9	MP0001968_abnormal_touch/_nociception	2.03292789
10	MP0008872_abnormal_physiological_respon	1.96891647
11	MP0008875_abnormal_xenobiotic_pharmacok	1.91548116
12	MP0006072_abnormal_retinal_apoptosis	1.83594617
13	MP0001835_abnormal_antigen_presentation	1.82604454
14	MP0005551_abnormal_eye_electrophysiolog	1.80762987
15	MP0002736_abnormal_nociception_after	1.77329299
16	MP0002837_dystrophic_cardiac_calcinosis	1.76926840
17	MP0004145_abnormal_muscle_electrophysio	1.72124004
18	MP0003787_abnormal_imprinting	1.70761490
19	MP0009785_altered_susceptibility_to	1.68949181
20	MP0004142_abnormal_muscle_tone	1.65811871
21	MP0003011_delayed_dark_adaptation	1.65685277
22	MP0001986_abnormal_taste_sensitivity	1.64344896
23	MP0003878_abnormal_ear_physiology	1.59551864
24	MP0005377_hearing/vestibular/ear_phenot	1.59551864
25	MP0002638_abnormal_pupillary_reflex	1.58689048
26	MP0004885_abnormal_endolymph	1.56803393
27	MP0000372_irregular_coat_pigmentation	1.56408947
28	MP0001873_stomach_inflammation	1.53190605
29	MP0005379_endocrine/exocrine_gland_phen	1.51005811
30	MP0005000_abnormal_immune_tolerance	1.49084734
31	MP0006276_abnormal_autonomic_nervous	1.48318296
32	MP0002277_abnormal_respiratory_mucosa	1.47561759
33	MP0008789_abnormal_olfactory_epithelium	1.43231212
34	MP0001800_abnormal_humoral_immune	1.42048269
35	MP0003763_abnormal_thymus_physiology	1.36491636
36	MP0001919_abnormal_reproductive_system	1.34573473
37	MP0001905_abnormal_dopamine_level	1.32822966
38	MP0002876_abnormal_thyroid_physiology	1.29801170
39	MP0003136_yellow_coat_color	1.29127283
40	MP0005389_reproductive_system_phenotype	1.27687643
41	MP0002148_abnormal_hypersensitivity_rea	1.27228602
42	MP0005253_abnormal_eye_physiology	1.25583028
43	MP0005360_urolithiasis	1.24022171
44	MP0002822_catalepsy	1.24013880
45	MP0002272_abnormal_nervous_system	1.23678460
46	MP0002723_abnormal_immune_serum	1.21436386
47	MP0005646_abnormal_pituitary_gland	1.21282398
48	MP0005084_abnormal_gallbladder_morpholo	1.21260808
49	MP0003880_abnormal_central_pattern	1.20825078
50	MP0000685_abnormal_immune_system	1.20590132
51	MP0005387_immune_system_phenotype	1.20231936
52	MP0001790_abnormal_immune_system	1.20231936
53	MP0002138_abnormal_hepatobiliary_system	1.18052500
54	MP0002095_abnormal_skin_pigmentation	1.17508806
55	MP0009333_abnormal_splenocyte_physiolog	1.16121099
56	MP0002420_abnormal_adaptive_immunity	1.15472342
57	MP0001529_abnormal_vocalization	1.14912817
58	MP0003195_calcinosis	1.14006850
59	MP0003866_abnormal_defecation	1.13216036
60	MP0001819_abnormal_immune_cell	1.11957658
61	MP0001485_abnormal_pinna_reflex	1.11078026
62	MP0004147_increased_porphyrin_level	1.07252689
63	MP0009764_decreased_sensitivity_to	1.05871490
64	MP0002160_abnormal_reproductive_system	1.05282864
65	MP0009745_abnormal_behavioral_response	1.05179105
66	MP0000631_abnormal_neuroendocrine_gland	1.04786881
67	MP0002653_abnormal_ependyma_morphology	1.04202218
68	MP0001970_abnormal_pain_threshold	1.03316311
69	MP0001486_abnormal_startle_reflex	1.03191596
70	MP0002733_abnormal_thermal_nociception	1.02272048
71	MP0005025_abnormal_response_to	1.02101079
72	MP0003122_maternal_imprinting	1.00993923
73	MP0002933_joint_inflammation	0.96041434
74	MP0002452_abnormal_antigen_presenting	0.95689639
75	MP0002234_abnormal_pharynx_morphology	0.95490047
76	MP0004043_abnormal_pH_regulation	0.93851835
77	MP0002735_abnormal_chemical_nociception	0.90909296
78	MP0008058_abnormal_DNA_repair	0.89903691
79	MP0005423_abnormal_somatic_nervous	0.88762938
80	MP0000049_abnormal_middle_ear	0.88361934
81	MP0005499_abnormal_olfactory_system	0.87297601
82	MP0005394_taste/olfaction_phenotype	0.87297601
83	MP0005174_abnormal_tail_pigmentation	0.87203435
84	MP0001188_hyperpigmentation	0.86183749
85	MP0004742_abnormal_vestibular_system	0.86065918
86	MP0005075_abnormal_melanosome_morpholog	0.85954142
87	MP0003121_genomic_imprinting	0.84088899
88	MP0000716_abnormal_immune_system	0.83750151
89	MP0001348_abnormal_lacrimal_gland	0.82268181
90	MP0001501_abnormal_sleep_pattern	0.81764076
91	MP0010386_abnormal_urinary_bladder	0.81702358
92	MP0003724_increased_susceptibility_to	0.81238920
93	MP0004133_heterotaxia	0.80753817
94	MP0008995_early_reproductive_senescence	0.78574901
95	MP0001293_anophthalmia	0.78429509
96	MP0003786_premature_aging	0.78010946
97	MP0001440_abnormal_grooming_behavior	0.77265641
98	MP0001845_abnormal_inflammatory_respons	0.75725058
99	MP0005167_abnormal_blood-brain_barrier	0.75293565
100	MP0010155_abnormal_intestine_physiology	0.73860368

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.30610507
2	Acute necrotizing encephalopathy (HP:0006965)	4.09387110
3	Mitochondrial inheritance (HP:0001427)	3.99797556
4	Lipid accumulation in hepatocytes (HP:0006561)	3.96964911
5	Congenital stationary night blindness (HP:0007642)	3.84490544
6	Increased hepatocellular lipid droplets (HP:0006565)	3.75504105
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.71048139
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.66525181
9	Increased CSF lactate (HP:0002490)	3.34892705
10	Progressive macrocephaly (HP:0004481)	3.32971489
11	Acute encephalopathy (HP:0006846)	3.31566262
12	Abnormality of cells of the erythroid lineage (HP:0012130)	3.28310420
13	IgG deficiency (HP:0004315)	3.26493618
14	Pancreatic cysts (HP:0001737)	3.21890355
15	Increased intramyocellular lipid droplets (HP:0012240)	3.20893464
16	Hepatocellular necrosis (HP:0001404)	3.10087932
17	Abnormal number of erythroid precursors (HP:0012131)	3.09789939
18	Renal Fanconi syndrome (HP:0001994)	3.09708952
19	Increased muscle lipid content (HP:0009058)	3.05170847
20	Abnormality of midbrain morphology (HP:0002418)	2.98945390
21	Molar tooth sign on MRI (HP:0002419)	2.98945390
22	Elevated erythrocyte sedimentation rate (HP:0003565)	2.94450792
23	Hepatic necrosis (HP:0002605)	2.92127338
24	Pancreatic fibrosis (HP:0100732)	2.88085752
25	Pendular nystagmus (HP:0012043)	2.86853767
26	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.85197092
27	Asplenia (HP:0001746)	2.84289278
28	Reticulocytopenia (HP:0001896)	2.78111490
29	Aplastic anemia (HP:0001915)	2.76964312
30	3-Methylglutaconic aciduria (HP:0003535)	2.70481059
31	Type II lissencephaly (HP:0007260)	2.60779878
32	Cerebral edema (HP:0002181)	2.59174144
33	True hermaphroditism (HP:0010459)	2.56854549
34	Macrocytic anemia (HP:0001972)	2.54011410
35	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.53149437
36	Severe combined immunodeficiency (HP:0004430)	2.53026264
37	Optic disc pallor (HP:0000543)	2.50513625
38	Exertional dyspnea (HP:0002875)	2.46406410
39	Attenuation of retinal blood vessels (HP:0007843)	2.43011127
40	Decreased central vision (HP:0007663)	2.42852744
41	Medial flaring of the eyebrow (HP:0010747)	2.37338858
42	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.36928343
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.36928343
44	Increased corneal curvature (HP:0100692)	2.30139668
45	Keratoconus (HP:0000563)	2.30139668
46	Hyperglycinemia (HP:0002154)	2.27171149
47	T lymphocytopenia (HP:0005403)	2.22940104
48	Congenital, generalized hypertrichosis (HP:0004540)	2.21518801
49	Polydipsia (HP:0001959)	2.20465739
50	Abnormal drinking behavior (HP:0030082)	2.20465739
51	Increased serum lactate (HP:0002151)	2.17476090
52	Abolished electroretinogram (ERG) (HP:0000550)	2.17475022
53	Abnormality of T cell number (HP:0011839)	2.17230398
54	Abnormality of the renal cortex (HP:0011035)	2.16898878
55	Nephronophthisis (HP:0000090)	2.16469335
56	Methylmalonic acidemia (HP:0002912)	2.15502033
57	Stomatitis (HP:0010280)	2.15201841
58	Abnormality of renal resorption (HP:0011038)	2.12830995
59	Sclerocornea (HP:0000647)	2.12783190
60	Supernumerary spleens (HP:0009799)	2.12262794
61	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.09874901
62	Pallor (HP:0000980)	2.09439575
63	Lactic acidosis (HP:0003128)	2.06569609
64	Septo-optic dysplasia (HP:0100842)	2.05035698
65	Methylmalonic aciduria (HP:0012120)	2.03544363
66	Abnormality of T cells (HP:0002843)	2.01517574
67	Renal cortical cysts (HP:0000803)	2.01187670
68	Hypoplasia of the pons (HP:0012110)	2.01037864
69	Abnormality of the pons (HP:0007361)	2.00888382
70	Colon cancer (HP:0003003)	2.00549409
71	Glycosuria (HP:0003076)	1.98434079
72	Abnormality of urine glucose concentration (HP:0011016)	1.98434079
73	Abnormality of alanine metabolism (HP:0010916)	1.98259619
74	Hyperalaninemia (HP:0003348)	1.98259619
75	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.98259619
76	Absent thumb (HP:0009777)	1.97641160
77	Respiratory failure (HP:0002878)	1.97102155
78	Hypoproteinemia (HP:0003075)	1.97089057
79	Thyroiditis (HP:0100646)	1.97051297
80	Increased IgM level (HP:0003496)	1.93746053
81	Lethargy (HP:0001254)	1.88489039
82	Cystic liver disease (HP:0006706)	1.87127315
83	Generalized aminoaciduria (HP:0002909)	1.85030470
84	Abnormality of the renal medulla (HP:0100957)	1.81944492
85	Anencephaly (HP:0002323)	1.78615857
86	Polyuria (HP:0000103)	1.77542468
87	Abnormality of the prostate (HP:0008775)	1.77446089
88	Hyperphosphaturia (HP:0003109)	1.77101953
89	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.76761189
90	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.76398878
91	Absent/shortened dynein arms (HP:0200106)	1.76398878
92	Combined immunodeficiency (HP:0005387)	1.76338875
93	Agitation (HP:0000713)	1.76182890
94	Constricted visual fields (HP:0001133)	1.76168302
95	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.74760867
96	Panhypogammaglobulinemia (HP:0003139)	1.73692529
97	Abnormality of B cell number (HP:0010975)	1.72551523
98	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.71513439
99	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.71237222
100	Respiratory difficulties (HP:0002880)	1.70091880

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.67954631
2	MAP4K2	3.33111473
3	KDR	3.10675916
4	ADRBK2	3.02881178
5	TAOK3	2.87834818
6	MAP4K1	2.70080076
7	WNK4	2.68737965
8	TLK1	2.54867450
9	BCKDK	2.52126406
10	GRK1	2.50022267
11	TESK2	2.45929421
12	PINK1	2.39751300
13	STK16	2.08294231
14	VRK2	2.04955332
15	ZAK	2.02289772
16	CDK19	1.95784527
17	LIMK1	1.95519522
18	BMPR1B	1.90106922
19	ITK	1.80131259
20	DYRK2	1.74096144
21	WNK3	1.69571427
22	FRK	1.67670717
23	MUSK	1.65328931
24	GRK6	1.51101155
25	TEC	1.48517285
26	NME1	1.47265257
27	VRK1	1.40793141
28	NUAK1	1.40221895
29	PASK	1.34175302
30	SYK	1.23264889
31	MAP3K11	1.22744589
32	TIE1	1.17598112
33	PRKCQ	1.12000015
34	INSRR	1.10078467
35	ADRBK1	1.02590370
36	GRK7	0.98100157
37	IKBKB	0.96486318
38	BTK	0.96394628
39	STK39	0.94050298
40	MAP3K12	0.92576829
41	CAMKK2	0.89803482
42	LRRK2	0.88212369
43	PIK3CA	0.86015722
44	RPS6KA5	0.84301961
45	MAPK13	0.83702471
46	MAPK15	0.82565690
47	LCK	0.81830957
48	IKBKE	0.80792455
49	ACVR1B	0.76097801
50	LYN	0.73640989
51	MAP2K2	0.73120942
52	PRKCG	0.67318662
53	OBSCN	0.65687713
54	OXSR1	0.64131387
55	PRKACA	0.61694409
56	CAMKK1	0.59845564
57	SIK2	0.59234306
58	CSNK1G3	0.58942779
59	PLK4	0.57929807
60	KIT	0.56283354
61	DAPK2	0.55515391
62	CSF1R	0.54674704
63	CAMK1	0.54619084
64	CSNK1G1	0.51705901
65	CSNK2A2	0.51485080
66	NTRK2	0.50357525
67	PRKCA	0.49995385
68	CSNK1G2	0.49914801
69	AURKA	0.49531083
70	CSNK1A1	0.47906248
71	NLK	0.47468900
72	MAP2K6	0.47322734
73	MYLK	0.47265208
74	CSNK2A1	0.43979687
75	PIM1	0.43502743
76	FES	0.43400070
77	IGF1R	0.42201799
78	ERBB3	0.41445389
79	PHKG2	0.41331726
80	PHKG1	0.41331726
81	NME2	0.38503356
82	CAMK2A	0.38224007
83	CSNK1A1L	0.36986127
84	MINK1	0.36070437
85	TGFBR1	0.35563469
86	DAPK3	0.35056845
87	PAK3	0.34260976
88	ABL1	0.33764041
89	RIPK4	0.31871185
90	PRKCE	0.31692669
91	PKN1	0.31515163
92	CSK	0.31512108
93	BUB1	0.30692189
94	EPHA4	0.29558846
95	GRK5	0.29378980
96	BMPR2	0.29199641
97	MATK	0.28971315
98	ROCK1	0.28041096
99	MARK3	0.27002357
100	PRKCI	0.26327190

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.03502638
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.85331394
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.46941074
4	Parkinsons disease_Homo sapiens_hsa05012	3.12386481
5	Proteasome_Homo sapiens_hsa03050	2.75160535
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.28616585
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.20337076
8	Alzheimers disease_Homo sapiens_hsa05010	2.20010010
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.19311637
10	Allograft rejection_Homo sapiens_hsa05330	2.12118179
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.11912967
12	Asthma_Homo sapiens_hsa05310	2.11783524
13	Sulfur relay system_Homo sapiens_hsa04122	2.09290955
14	Huntingtons disease_Homo sapiens_hsa05016	2.03996684
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.99285599
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.97083025
17	RNA polymerase_Homo sapiens_hsa03020	1.93151460
18	Phototransduction_Homo sapiens_hsa04744	1.89309515
19	Antigen processing and presentation_Homo sapiens_hsa04612	1.78934447
20	Type I diabetes mellitus_Homo sapiens_hsa04940	1.69034298
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.68196141
22	Protein export_Homo sapiens_hsa03060	1.67038323
23	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.66197058
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.62070199
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.61971159
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.57720298
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.52334004
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31991383
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.25229858
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.19371820
31	Rheumatoid arthritis_Homo sapiens_hsa05323	1.17963727
32	RNA degradation_Homo sapiens_hsa03018	1.16023675
33	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.11624378
34	Olfactory transduction_Homo sapiens_hsa04740	1.10945890
35	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.08903438
36	Nicotine addiction_Homo sapiens_hsa05033	1.07317989
37	Homologous recombination_Homo sapiens_hsa03440	1.05295914
38	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.02094977
39	Butanoate metabolism_Homo sapiens_hsa00650	0.95689370
40	Caffeine metabolism_Homo sapiens_hsa00232	0.92369235
41	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.89120721
42	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.88816005
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.87372814
44	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.81594171
45	Retinol metabolism_Homo sapiens_hsa00830	0.80535918
46	Fanconi anemia pathway_Homo sapiens_hsa03460	0.80492591
47	One carbon pool by folate_Homo sapiens_hsa00670	0.80280442
48	Basal transcription factors_Homo sapiens_hsa03022	0.79954635
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77925167
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.77712249
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77149428
52	Purine metabolism_Homo sapiens_hsa00230	0.76326097
53	Peroxisome_Homo sapiens_hsa04146	0.76199244
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.75484248
55	Propanoate metabolism_Homo sapiens_hsa00640	0.74229993
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.73896484
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.73094509
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70111813
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.70041081
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.69068795
61	Morphine addiction_Homo sapiens_hsa05032	0.69036288
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68453067
63	Taste transduction_Homo sapiens_hsa04742	0.66348781
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66270883
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.65426083
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.63600295
67	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.61052811
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59783707
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57872930
70	Metabolic pathways_Homo sapiens_hsa01100	0.57734817
71	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.56880464
72	Viral myocarditis_Homo sapiens_hsa05416	0.55125235
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54564515
74	Sulfur metabolism_Homo sapiens_hsa00920	0.54379095
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50256901
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49279473
77	Serotonergic synapse_Homo sapiens_hsa04726	0.48415030
78	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46312324
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.45869663
80	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.44716589
81	Regulation of autophagy_Homo sapiens_hsa04140	0.41842462
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.41368871
83	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.40818035
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39306825
85	GABAergic synapse_Homo sapiens_hsa04727	0.39277719
86	Malaria_Homo sapiens_hsa05144	0.39222863
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.38869703
88	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.38753481
89	DNA replication_Homo sapiens_hsa03030	0.37429651
90	Salivary secretion_Homo sapiens_hsa04970	0.36742088
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.34621764
92	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.28799265
93	Measles_Homo sapiens_hsa05162	0.28215156
94	Base excision repair_Homo sapiens_hsa03410	0.25858094
95	RNA transport_Homo sapiens_hsa03013	0.25342694
96	Circadian entrainment_Homo sapiens_hsa04713	0.25166632
97	Spliceosome_Homo sapiens_hsa03040	0.24633528
98	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.22679285
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.22409349
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.21624802

RPL10P15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »