ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.07624582
2	DNA deamination (GO:0045006)	5.65948591
3	ATP synthesis coupled proton transport (GO:0015986)	5.39219093
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.39219093
5	viral transcription (GO:0019083)	5.05342887
6	translational termination (GO:0006415)	4.84779383
7	chaperone-mediated protein transport (GO:0072321)	4.76557527
8	behavioral response to nicotine (GO:0035095)	4.64965436
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.61682966
10	maturation of SSU-rRNA (GO:0030490)	4.47253685
11	translational elongation (GO:0006414)	4.26833510
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.25748365
13	ribosomal small subunit biogenesis (GO:0042274)	4.25046345
14	protein complex biogenesis (GO:0070271)	4.21841138
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.21453365
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.21453365
17	NADH dehydrogenase complex assembly (GO:0010257)	4.21453365
18	cotranslational protein targeting to membrane (GO:0006613)	4.19356592
19	protein targeting to ER (GO:0045047)	4.14970273
20	protein neddylation (GO:0045116)	4.14655010
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.01166737
22	cytidine metabolic process (GO:0046087)	3.97771459
23	cytidine catabolic process (GO:0006216)	3.97771459
24	cytidine deamination (GO:0009972)	3.97771459
25	protein localization to endoplasmic reticulum (GO:0070972)	3.94612243
26	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.93744750
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.89211957
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.75810658
29	electron transport chain (GO:0022900)	3.70639197
30	respiratory electron transport chain (GO:0022904)	3.69635474
31	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.64848150
32	viral life cycle (GO:0019058)	3.63629930
33	cellular protein complex disassembly (GO:0043624)	3.52933369
34	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.52582680
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.51516096
36	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.51516096
37	negative regulation of mast cell activation (GO:0033004)	3.36688571
38	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.36189377
39	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.31855294
40	ubiquinone biosynthetic process (GO:0006744)	3.28069988
41	ATP biosynthetic process (GO:0006754)	3.19676255
42	L-fucose catabolic process (GO:0042355)	3.18860334
43	fucose catabolic process (GO:0019317)	3.18860334
44	L-fucose metabolic process (GO:0042354)	3.18860334
45	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.16166806
46	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.13523536
47	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.12547151
48	translational initiation (GO:0006413)	3.11551632
49	translation (GO:0006412)	3.10173557
50	ribosomal large subunit biogenesis (GO:0042273)	3.07376149
51	GTP biosynthetic process (GO:0006183)	3.05053548
52	protein polyglutamylation (GO:0018095)	3.02637591
53	response to pheromone (GO:0019236)	3.02547510
54	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.99706368
55	hydrogen ion transmembrane transport (GO:1902600)	2.96767733
56	ubiquinone metabolic process (GO:0006743)	2.88546525
57	protein complex disassembly (GO:0043241)	2.85486950
58	proton transport (GO:0015992)	2.81653711
59	cellular component biogenesis (GO:0044085)	2.80526446
60	pseudouridine synthesis (GO:0001522)	2.80101991
61	preassembly of GPI anchor in ER membrane (GO:0016254)	2.78596261
62	hydrogen transport (GO:0006818)	2.77515527
63	respiratory chain complex IV assembly (GO:0008535)	2.76845598
64	negative regulation of telomere maintenance (GO:0032205)	2.75950797
65	positive regulation of defense response to virus by host (GO:0002230)	2.73098697
66	quinone biosynthetic process (GO:1901663)	2.72123130
67	macromolecular complex disassembly (GO:0032984)	2.71975920
68	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.67907703
69	cytochrome complex assembly (GO:0017004)	2.67274216
70	platelet dense granule organization (GO:0060155)	2.66390025
71	kynurenine metabolic process (GO:0070189)	2.65248517
72	mannosylation (GO:0097502)	2.63720009
73	protein targeting to membrane (GO:0006612)	2.62651188
74	iron-sulfur cluster assembly (GO:0016226)	2.62235634
75	metallo-sulfur cluster assembly (GO:0031163)	2.62235634
76	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.60797369
77	termination of RNA polymerase III transcription (GO:0006386)	2.60031379
78	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.60031379
79	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.59358230
80	parturition (GO:0007567)	2.56135919
81	regulation of regulatory T cell differentiation (GO:0045589)	2.56046088
82	protein-cofactor linkage (GO:0018065)	2.52868411
83	tRNA processing (GO:0008033)	2.51128020
84	indolalkylamine metabolic process (GO:0006586)	2.50703227
85	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.49928224
86	indole-containing compound catabolic process (GO:0042436)	2.49462103
87	indolalkylamine catabolic process (GO:0046218)	2.49462103
88	tryptophan catabolic process (GO:0006569)	2.49462103
89	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.49153616
90	positive regulation of respiratory burst (GO:0060267)	2.48505948
91	GPI anchor metabolic process (GO:0006505)	2.47500161
92	positive regulation of prostaglandin secretion (GO:0032308)	2.46694162
93	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.46423613
94	mRNA catabolic process (GO:0006402)	2.45382461
95	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.44403961
96	UTP metabolic process (GO:0046051)	2.43066273
97	UTP biosynthetic process (GO:0006228)	2.41728782
98	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.39999119
99	regulation of isotype switching to IgG isotypes (GO:0048302)	2.39705513
100	S-adenosylmethionine metabolic process (GO:0046500)	2.37859311

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.51035403
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.18795750
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.87356859
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.81082663
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.79512588
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.72908800
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.72760947
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.65285898
9	VDR_22108803_ChIP-Seq_LS180_Human	2.57985462
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.51658156
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.49869039
12	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.47117148
13	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.19550000
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.15074664
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.13711033
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.06894586
17	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.95342084
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.90156410
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.82565505
20	IRF1_19129219_ChIP-ChIP_H3396_Human	1.78757645
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.75001240
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69858729
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.66208498
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.61165341
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.58332645
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.54029647
27	IGF1R_20145208_ChIP-Seq_DFB_Human	1.51647442
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51504899
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.49852353
30	TAF2_19829295_ChIP-Seq_ESCs_Human	1.48562360
31	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.45834730
32	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.41586623
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.41413110
34	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.39269745
35	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.37129413
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.36218381
37	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.35810812
38	NANOG_20526341_ChIP-Seq_ESCs_Human	1.34692732
39	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.32079853
40	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.30552216
41	AR_20517297_ChIP-Seq_VCAP_Human	1.30231960
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.29924318
43	BCL6_27268052_Chip-Seq_Bcells_Human	1.29474472
44	ERA_21632823_ChIP-Seq_H3396_Human	1.28140425
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27389847
46	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.26854211
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.26475532
48	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.25865201
49	MYC_19829295_ChIP-Seq_ESCs_Human	1.24602665
50	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.24305685
51	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24189454
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23732727
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23732727
54	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.22438632
55	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.22355981
56	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22217715
57	NCOR_22424771_ChIP-Seq_293T_Human	1.22000455
58	ELK1_19687146_ChIP-ChIP_HELA_Human	1.21837310
59	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.21394009
60	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.21318162
61	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.19323068
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18804520
63	EWS_26573619_Chip-Seq_HEK293_Human	1.16049666
64	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.16013781
65	GATA3_26560356_Chip-Seq_TH2_Human	1.15679562
66	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.14044056
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13483156
68	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.12857305
69	CTCF_20526341_ChIP-Seq_ESCs_Human	1.10668180
70	TTF2_22483619_ChIP-Seq_HELA_Human	1.10571995
71	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.09852650
72	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.08487415
73	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.06620219
74	REST_21632747_ChIP-Seq_MESCs_Mouse	1.06009431
75	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.05303547
76	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.02045054
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01453843
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00442272
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00442272
80	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.00117803
81	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99968529
82	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98357308
83	CBP_20019798_ChIP-Seq_JUKART_Human	0.98357308
84	STAT1_20625510_ChIP-Seq_HELA_Human	0.97596491
85	P300_27268052_Chip-Seq_Bcells_Human	0.97501500
86	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.97408118
87	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.97110325
88	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.96513447
89	GABP_19822575_ChIP-Seq_HepG2_Human	0.94536277
90	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94207936
91	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.94202715
92	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93672022
93	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.93186179
94	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.93128643
95	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.93056160
96	ER_23166858_ChIP-Seq_MCF-7_Human	0.92768616
97	CIITA_25753668_ChIP-Seq_RAJI_Human	0.90395146
98	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.89745932
99	ERG_20517297_ChIP-Seq_VCAP_Human	0.89568228
100	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.88647066

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.52898199
2	MP0009379_abnormal_foot_pigmentation	3.51122226
3	MP0005671_abnormal_response_to	3.50084848
4	MP0003646_muscle_fatigue	2.71166641
5	MP0003787_abnormal_imprinting	2.69089746
6	MP0008877_abnormal_DNA_methylation	2.55254871
7	MP0001835_abnormal_antigen_presentation	2.27817058
8	MP0004885_abnormal_endolymph	2.17625911
9	MP0006072_abnormal_retinal_apoptosis	2.17492103
10	MP0002138_abnormal_hepatobiliary_system	2.05582584
11	MP0008872_abnormal_physiological_respon	2.03807535
12	MP0004142_abnormal_muscle_tone	1.94022176
13	MP0008875_abnormal_xenobiotic_pharmacok	1.87993175
14	MP0002102_abnormal_ear_morphology	1.86961136
15	MP0004147_increased_porphyrin_level	1.83917424
16	MP0001968_abnormal_touch/_nociception	1.68794406
17	MP0005551_abnormal_eye_electrophysiolog	1.67683926
18	MP0002876_abnormal_thyroid_physiology	1.65985607
19	MP0002837_dystrophic_cardiac_calcinosis	1.58352487
20	MP0005645_abnormal_hypothalamus_physiol	1.57178511
21	MP0002148_abnormal_hypersensitivity_rea	1.56504773
22	MP0002736_abnormal_nociception_after	1.54872446
23	MP0005360_urolithiasis	1.54029879
24	MP0003011_delayed_dark_adaptation	1.52771978
25	MP0001905_abnormal_dopamine_level	1.52577435
26	MP0001800_abnormal_humoral_immune	1.52137367
27	MP0000685_abnormal_immune_system	1.47857348
28	MP0001873_stomach_inflammation	1.43196844
29	MP0005000_abnormal_immune_tolerance	1.42675026
30	MP0005253_abnormal_eye_physiology	1.42038935
31	MP0003195_calcinosis	1.41771232
32	MP0006276_abnormal_autonomic_nervous	1.38104998
33	MP0009785_altered_susceptibility_to	1.37943966
34	MP0002638_abnormal_pupillary_reflex	1.36466361
35	MP0004145_abnormal_muscle_electrophysio	1.35434515
36	MP0002163_abnormal_gland_morphology	1.33290457
37	MP0005646_abnormal_pituitary_gland	1.32819498
38	MP0002653_abnormal_ependyma_morphology	1.27606791
39	MP0002272_abnormal_nervous_system	1.26377684
40	MP0005084_abnormal_gallbladder_morpholo	1.26284402
41	MP0005387_immune_system_phenotype	1.25177527
42	MP0001790_abnormal_immune_system	1.25177527
43	MP0003878_abnormal_ear_physiology	1.24266755
44	MP0005377_hearing/vestibular/ear_phenot	1.24266755
45	MP0009764_decreased_sensitivity_to	1.22455946
46	MP0008789_abnormal_olfactory_epithelium	1.21640609
47	MP0005075_abnormal_melanosome_morpholog	1.18928853
48	MP0009333_abnormal_splenocyte_physiolog	1.18910723
49	MP0001529_abnormal_vocalization	1.18894766
50	MP0001986_abnormal_taste_sensitivity	1.18405937
51	MP0002723_abnormal_immune_serum	1.18180195
52	MP0006036_abnormal_mitochondrial_physio	1.17407809
53	MP0005389_reproductive_system_phenotype	1.16499885
54	MP0006082_CNS_inflammation	1.13999027
55	MP0001919_abnormal_reproductive_system	1.13842779
56	MP0002234_abnormal_pharynx_morphology	1.13714376
57	MP0009745_abnormal_behavioral_response	1.13358737
58	MP0000372_irregular_coat_pigmentation	1.12347924
59	MP0003121_genomic_imprinting	1.10939986
60	MP0003866_abnormal_defecation	1.09464297
61	MP0001440_abnormal_grooming_behavior	1.07723344
62	MP0002095_abnormal_skin_pigmentation	1.07475125
63	MP0004742_abnormal_vestibular_system	1.05884643
64	MP0002420_abnormal_adaptive_immunity	1.02975244
65	MP0002160_abnormal_reproductive_system	1.01587113
66	MP0001819_abnormal_immune_cell	1.01506115
67	MP0003806_abnormal_nucleotide_metabolis	0.99503692
68	MP0002452_abnormal_antigen_presenting	0.98909588
69	MP0003436_decreased_susceptibility_to	0.98823196
70	MP0002933_joint_inflammation	0.98324872
71	MP0005025_abnormal_response_to	0.98142757
72	MP0000049_abnormal_middle_ear	0.97939966
73	MP0003122_maternal_imprinting	0.97596976
74	MP0001485_abnormal_pinna_reflex	0.97080433
75	MP0005379_endocrine/exocrine_gland_phen	0.96653747
76	MP0001970_abnormal_pain_threshold	0.94616563
77	MP0001188_hyperpigmentation	0.92240112
78	MP0002733_abnormal_thermal_nociception	0.90627746
79	MP0000230_abnormal_systemic_arterial	0.90447387
80	MP0000631_abnormal_neuroendocrine_gland	0.89758668
81	MP0003724_increased_susceptibility_to	0.89717093
82	MP0004043_abnormal_pH_regulation	0.88793695
83	MP0003186_abnormal_redox_activity	0.88666325
84	MP0001293_anophthalmia	0.88420523
85	MP0002277_abnormal_respiratory_mucosa	0.88101644
86	MP0002938_white_spotting	0.86162189
87	MP0003283_abnormal_digestive_organ	0.85862791
88	MP0001501_abnormal_sleep_pattern	0.84961120
89	MP0005636_abnormal_mineral_homeostasis	0.84738794
90	MP0008775_abnormal_heart_ventricle	0.84227323
91	MP0010155_abnormal_intestine_physiology	0.84009320
92	MP0001486_abnormal_startle_reflex	0.83628092
93	MP0005195_abnormal_posterior_eye	0.83507676
94	MP0001765_abnormal_ion_homeostasis	0.82382256
95	MP0003880_abnormal_central_pattern	0.80675979
96	MP0001663_abnormal_digestive_system	0.78734710
97	MP0009046_muscle_twitch	0.76912740
98	MP0003567_abnormal_fetal_cardiomyocyte	0.76874376
99	MP0006035_abnormal_mitochondrial_morpho	0.76681095
100	MP0002557_abnormal_social/conspecific_i	0.75831370

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.41947822
2	Congenital stationary night blindness (HP:0007642)	4.24509655
3	Mitochondrial inheritance (HP:0001427)	4.04112149
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.94343990
5	Acute encephalopathy (HP:0006846)	3.83299534
6	Increased CSF lactate (HP:0002490)	3.60207617
7	Progressive macrocephaly (HP:0004481)	3.58385795
8	3-Methylglutaconic aciduria (HP:0003535)	3.54961857
9	Hepatocellular necrosis (HP:0001404)	3.52283432
10	Reticulocytopenia (HP:0001896)	3.22061989
11	Hepatic necrosis (HP:0002605)	3.16778295
12	Pancreatic cysts (HP:0001737)	3.06533901
13	Abnormality of cells of the erythroid lineage (HP:0012130)	3.01335812
14	Increased hepatocellular lipid droplets (HP:0006565)	2.99880808
15	IgG deficiency (HP:0004315)	2.96691522
16	Elevated erythrocyte sedimentation rate (HP:0003565)	2.90471763
17	Molar tooth sign on MRI (HP:0002419)	2.82463879
18	Abnormality of midbrain morphology (HP:0002418)	2.82463879
19	Abnormal rod and cone electroretinograms (HP:0008323)	2.79414211
20	Pancreatic fibrosis (HP:0100732)	2.78484969
21	Cerebral edema (HP:0002181)	2.77848714
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.77577236
23	Nephronophthisis (HP:0000090)	2.77129501
24	Abnormal number of erythroid precursors (HP:0012131)	2.75124044
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.72268423
26	Lipid accumulation in hepatocytes (HP:0006561)	2.71956155
27	Increased serum lactate (HP:0002151)	2.69622313
28	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.68595677
29	Hypoproteinemia (HP:0003075)	2.64481714
30	Renal Fanconi syndrome (HP:0001994)	2.62511768
31	Optic disc pallor (HP:0000543)	2.59619229
32	Asplenia (HP:0001746)	2.58574605
33	Abolished electroretinogram (ERG) (HP:0000550)	2.51866292
34	Increased intramyocellular lipid droplets (HP:0012240)	2.49103852
35	Abnormality of B cell number (HP:0010975)	2.48627980
36	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.45336503
37	Abnormality of the renal cortex (HP:0011035)	2.44101659
38	Lactic acidosis (HP:0003128)	2.42320783
39	True hermaphroditism (HP:0010459)	2.40097721
40	Macrocytic anemia (HP:0001972)	2.39602844
41	Congenital, generalized hypertrichosis (HP:0004540)	2.33934256
42	Abnormality of the renal medulla (HP:0100957)	2.28742480
43	Attenuation of retinal blood vessels (HP:0007843)	2.28196061
44	Type II lissencephaly (HP:0007260)	2.27152255
45	Severe combined immunodeficiency (HP:0004430)	2.25394915
46	Increased IgM level (HP:0003496)	2.21227101
47	Pendular nystagmus (HP:0012043)	2.20371833
48	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.20020286
49	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.20020286
50	Stomatitis (HP:0010280)	2.17810074
51	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.16925279
52	Panhypogammaglobulinemia (HP:0003139)	2.13414756
53	Hyperglycinemia (HP:0002154)	2.13379419
54	Abnormality of the prostate (HP:0008775)	2.11712722
55	Abnormality of eosinophils (HP:0001879)	2.10762451
56	Lethargy (HP:0001254)	2.05649675
57	Exertional dyspnea (HP:0002875)	2.03518514
58	Polydipsia (HP:0001959)	2.01979254
59	Abnormal drinking behavior (HP:0030082)	2.01979254
60	Methylmalonic aciduria (HP:0012120)	2.00776920
61	Increased muscle lipid content (HP:0009058)	1.99840449
62	Respiratory failure (HP:0002878)	1.99748814
63	Pallor (HP:0000980)	1.96289379
64	Methylmalonic acidemia (HP:0002912)	1.96184525
65	Type 2 muscle fiber atrophy (HP:0003554)	1.96118893
66	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.96031605
67	Thyroiditis (HP:0100646)	1.94801082
68	Medial flaring of the eyebrow (HP:0010747)	1.94739218
69	Colon cancer (HP:0003003)	1.94593247
70	Abnormality of magnesium homeostasis (HP:0004921)	1.93886978
71	Abnormality of T cells (HP:0002843)	1.92181954
72	Prostate neoplasm (HP:0100787)	1.91179059
73	Sclerocornea (HP:0000647)	1.90126138
74	Renal cortical cysts (HP:0000803)	1.89628887
75	Decreased central vision (HP:0007663)	1.87279537
76	Absent thumb (HP:0009777)	1.85807161
77	Leukodystrophy (HP:0002415)	1.85227806
78	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.84464226
79	Absent/shortened dynein arms (HP:0200106)	1.84464226
80	Hypomagnesemia (HP:0002917)	1.84364074
81	Abnormality of urine glucose concentration (HP:0011016)	1.83216273
82	Glycosuria (HP:0003076)	1.83216273
83	Eosinophilia (HP:0001880)	1.83171440
84	Exercise intolerance (HP:0003546)	1.83091729
85	Abnormality of T cell physiology (HP:0011840)	1.82898745
86	Abnormality of T cell number (HP:0011839)	1.82845794
87	Polyuria (HP:0000103)	1.81136768
88	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.80539756
89	Autoimmune hemolytic anemia (HP:0001890)	1.79267915
90	Keratoconus (HP:0000563)	1.76334011
91	Increased corneal curvature (HP:0100692)	1.76334011
92	Progressive microcephaly (HP:0000253)	1.76313594
93	Leukocytosis (HP:0001974)	1.76105498
94	B lymphocytopenia (HP:0010976)	1.76062008
95	Agitation (HP:0000713)	1.75518942
96	Cerebellar dysplasia (HP:0007033)	1.74102895
97	Tubular atrophy (HP:0000092)	1.71633876
98	Delayed CNS myelination (HP:0002188)	1.71610504
99	Autoimmune thrombocytopenia (HP:0001973)	1.71556152
100	Dicarboxylic aciduria (HP:0003215)	1.70601922

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.16602363
2	TXK	3.16441629
3	WNK4	3.01532997
4	TLK1	2.82492795
5	BCKDK	2.73571464
6	ADRBK2	2.71724665
7	BMPR1B	2.69406611
8	GRK1	2.62999235
9	TAOK3	2.28059004
10	MAP4K1	2.14799730
11	VRK2	2.09420077
12	NUAK1	2.01529561
13	PINK1	2.00645057
14	TIE1	1.93665408
15	ZAK	1.90593523
16	KDR	1.89961776
17	FRK	1.70824407
18	CDK19	1.67297540
19	STK16	1.66140759
20	CAMKK2	1.54600277
21	DYRK2	1.51502405
22	WNK3	1.46195309
23	TEC	1.38477961
24	STK39	1.36069743
25	ITK	1.35817191
26	MAP3K11	1.33653409
27	IRAK4	1.32271332
28	GRK6	1.31633259
29	OXSR1	1.18886240
30	IKBKB	1.14764273
31	MAPK13	1.13721163
32	PRKCQ	1.10796532
33	INSRR	1.09146968
34	SYK	1.08236886
35	PRKCH	1.07843424
36	KIT	1.00120438
37	TAF1	0.98072820
38	TESK2	0.97257603
39	FES	0.92849377
40	VRK1	0.88222739
41	PIK3CA	0.87339723
42	PHKG1	0.87088398
43	PHKG2	0.87088398
44	PASK	0.86399691
45	CSNK1G2	0.83936758
46	RPS6KA5	0.83586090
47	ADRBK1	0.83036850
48	CSNK1G3	0.82896456
49	MAPKAPK3	0.78821800
50	MAP2K6	0.77944287
51	LCK	0.76659681
52	PLK2	0.74901111
53	BTK	0.74369535
54	MAP2K2	0.72339507
55	SRPK1	0.68816117
56	DAPK1	0.67635206
57	NME2	0.65621287
58	DAPK2	0.65451941
59	IKBKE	0.65024461
60	CAMKK1	0.63014310
61	ABL2	0.62777586
62	EPHA4	0.61561540
63	NME1	0.61518303
64	PIM2	0.61195721
65	ACVR1B	0.61002381
66	CDK8	0.60545668
67	PRKACA	0.59610247
68	EPHB2	0.59468570
69	CSNK1A1L	0.57795552
70	MAP2K7	0.57368110
71	CAMK1	0.57049593
72	LYN	0.56999392
73	PIK3CG	0.56266952
74	OBSCN	0.55241172
75	CSNK1G1	0.54092625
76	EPHA3	0.53341138
77	PRKCG	0.52216726
78	MATK	0.49347797
79	LIMK1	0.49163318
80	GRK7	0.48735335
81	PRKCA	0.48280849
82	MARK3	0.48183891
83	CSNK2A2	0.46292336
84	PRKCI	0.45014877
85	PRKCD	0.44038369
86	PLK4	0.43176301
87	MUSK	0.42816274
88	CSNK2A1	0.41986611
89	ILK	0.41664274
90	CAMK2A	0.40949437
91	MAPKAPK5	0.40680685
92	RPS6KA6	0.40143214
93	GRK5	0.38754962
94	MAP3K12	0.38441467
95	IGF1R	0.35846349
96	PIM1	0.35512873
97	WNK1	0.35446522
98	BRAF	0.35136643
99	TGFBR1	0.34923345
100	JAK3	0.34073261

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.08365962
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.54030206
3	Asthma_Homo sapiens_hsa05310	3.31837661
4	Allograft rejection_Homo sapiens_hsa05330	2.99527151
5	Parkinsons disease_Homo sapiens_hsa05012	2.98241030
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.87084144
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.78269162
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.68157783
9	RNA polymerase_Homo sapiens_hsa03020	2.61706324
10	Proteasome_Homo sapiens_hsa03050	2.41909389
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.39178363
12	Primary immunodeficiency_Homo sapiens_hsa05340	2.35103820
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.10578457
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.96959719
15	Alzheimers disease_Homo sapiens_hsa05010	1.95769228
16	Huntingtons disease_Homo sapiens_hsa05016	1.88843352
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.84432799
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80449486
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.77556753
20	Phototransduction_Homo sapiens_hsa04744	1.73271301
21	Protein export_Homo sapiens_hsa03060	1.71891416
22	Sulfur relay system_Homo sapiens_hsa04122	1.52258110
23	Antigen processing and presentation_Homo sapiens_hsa04612	1.51155520
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.46815777
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.45533431
26	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.40197436
27	Rheumatoid arthritis_Homo sapiens_hsa05323	1.36854508
28	Fat digestion and absorption_Homo sapiens_hsa04975	1.25929211
29	Sulfur metabolism_Homo sapiens_hsa00920	1.22242682
30	RNA degradation_Homo sapiens_hsa03018	1.20089739
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.17809120
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.17594619
33	Caffeine metabolism_Homo sapiens_hsa00232	1.12438314
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.10363919
35	Homologous recombination_Homo sapiens_hsa03440	1.10215577
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.08633222
37	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.04153085
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03025149
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.02998501
40	Viral myocarditis_Homo sapiens_hsa05416	1.02528510
41	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.02491367
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94134194
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.92682955
44	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.90723204
45	Peroxisome_Homo sapiens_hsa04146	0.90642923
46	Propanoate metabolism_Homo sapiens_hsa00640	0.89372374
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.88506011
48	One carbon pool by folate_Homo sapiens_hsa00670	0.84410540
49	Purine metabolism_Homo sapiens_hsa00230	0.83285919
50	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80984016
51	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.79656465
52	Nicotine addiction_Homo sapiens_hsa05033	0.78799355
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.78611228
54	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.78386972
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.77196161
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75787750
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.75407582
58	Basal transcription factors_Homo sapiens_hsa03022	0.74780378
59	Retinol metabolism_Homo sapiens_hsa00830	0.72414719
60	Butanoate metabolism_Homo sapiens_hsa00650	0.71587563
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.71364643
62	Regulation of autophagy_Homo sapiens_hsa04140	0.67387651
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67349479
64	Fatty acid elongation_Homo sapiens_hsa00062	0.62517808
65	Leishmaniasis_Homo sapiens_hsa05140	0.62115771
66	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.61753291
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60968050
68	Metabolic pathways_Homo sapiens_hsa01100	0.60583140
69	Olfactory transduction_Homo sapiens_hsa04740	0.59354253
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58800509
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57754164
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.56443737
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54799257
74	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53634589
75	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.52062226
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.51865638
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50704796
78	Spliceosome_Homo sapiens_hsa03040	0.47750658
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46681615
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46081850
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45427902
82	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.44990096
83	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.41302724
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.38706199
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37688720
86	Morphine addiction_Homo sapiens_hsa05032	0.36986751
87	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36788753
88	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.35659019
89	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.34735571
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33314451
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32980876
92	RNA transport_Homo sapiens_hsa03013	0.31822543
93	Glutathione metabolism_Homo sapiens_hsa00480	0.30506881
94	Salivary secretion_Homo sapiens_hsa04970	0.30463674
95	Mineral absorption_Homo sapiens_hsa04978	0.29569535
96	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.29545626
97	Serotonergic synapse_Homo sapiens_hsa04726	0.26891719
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.26442232
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.25461023
100	Taste transduction_Homo sapiens_hsa04742	0.25041941

RPL10P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »