RPL10P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.23725462
2ribosomal small subunit assembly (GO:0000028)5.20952665
3viral transcription (GO:0019083)5.20681539
4translational termination (GO:0006415)4.99825986
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.98354602
6ATP synthesis coupled proton transport (GO:0015986)4.98354602
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.62493108
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.55998684
9behavioral response to nicotine (GO:0035095)4.53830136
10translational elongation (GO:0006414)4.49567843
11protein targeting to ER (GO:0045047)4.47608979
12cotranslational protein targeting to membrane (GO:0006613)4.46791558
13protein neddylation (GO:0045116)4.33288289
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.27724651
15protein localization to endoplasmic reticulum (GO:0070972)4.27344660
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.25950426
17regulation of regulatory T cell differentiation (GO:0045589)4.20129713
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.14635052
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.14635052
20ribosomal small subunit biogenesis (GO:0042274)4.09263168
21maturation of SSU-rRNA (GO:0030490)4.00729780
22regulation of isotype switching to IgG isotypes (GO:0048302)3.97696452
23viral life cycle (GO:0019058)3.75024467
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74159786
25cytidine metabolic process (GO:0046087)3.71503770
26cytidine catabolic process (GO:0006216)3.71503770
27cytidine deamination (GO:0009972)3.71503770
28cellular protein complex disassembly (GO:0043624)3.67304138
29regulation of immunoglobulin secretion (GO:0051023)3.60614804
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55509977
31positive regulation of defense response to virus by host (GO:0002230)3.44571430
32GTP biosynthetic process (GO:0006183)3.44459930
33electron transport chain (GO:0022900)3.40778224
34ribosomal large subunit biogenesis (GO:0042273)3.39772542
35respiratory electron transport chain (GO:0022904)3.39766227
36water-soluble vitamin biosynthetic process (GO:0042364)3.37834751
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.37466576
38pyrimidine ribonucleoside catabolic process (GO:0046133)3.33710717
39translational initiation (GO:0006413)3.31860671
40translation (GO:0006412)3.28143172
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24355255
42positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.23796088
43termination of RNA polymerase III transcription (GO:0006386)3.23568611
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.23568611
45mannosylation (GO:0097502)3.13894485
46protein-cofactor linkage (GO:0018065)3.13609674
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13561216
48cellular response to interleukin-15 (GO:0071350)3.11547064
49protein complex biogenesis (GO:0070271)3.06023838
50positive regulation of T cell mediated cytotoxicity (GO:0001916)3.04299860
51purine nucleoside triphosphate biosynthetic process (GO:0009145)3.03873119
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.03382359
53signal peptide processing (GO:0006465)3.03358104
54regulation of chronic inflammatory response (GO:0002676)3.00149743
55mast cell activation (GO:0045576)2.98932293
56protein complex disassembly (GO:0043241)2.97107896
57protein targeting to membrane (GO:0006612)2.91790997
58ATP biosynthetic process (GO:0006754)2.90410495
59regulation of T cell mediated cytotoxicity (GO:0001914)2.88880404
60regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.86576666
61macromolecular complex disassembly (GO:0032984)2.85658948
62GPI anchor metabolic process (GO:0006505)2.85451494
63metallo-sulfur cluster assembly (GO:0031163)2.81645319
64iron-sulfur cluster assembly (GO:0016226)2.81645319
65hydrogen ion transmembrane transport (GO:1902600)2.78888806
66positive regulation of prostaglandin secretion (GO:0032308)2.77372161
67nuclear-transcribed mRNA catabolic process (GO:0000956)2.76885382
68UTP biosynthetic process (GO:0006228)2.74790024
69mitochondrial respiratory chain complex assembly (GO:0033108)2.74531954
70pseudouridine synthesis (GO:0001522)2.70502520
71positive regulation of fatty acid transport (GO:2000193)2.67667606
72positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.67446986
73proton transport (GO:0015992)2.66995507
74mitochondrial respiratory chain complex I assembly (GO:0032981)2.66233946
75NADH dehydrogenase complex assembly (GO:0010257)2.66233946
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66233946
77tRNA processing (GO:0008033)2.64382776
78respiratory chain complex IV assembly (GO:0008535)2.64283267
79positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.63069967
80hydrogen transport (GO:0006818)2.62432221
81GPI anchor biosynthetic process (GO:0006506)2.61439963
82positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.60153150
83mRNA catabolic process (GO:0006402)2.59707667
84response to pheromone (GO:0019236)2.57088033
85fucose catabolic process (GO:0019317)2.56587348
86L-fucose metabolic process (GO:0042354)2.56587348
87L-fucose catabolic process (GO:0042355)2.56587348
88regulation of leukocyte mediated cytotoxicity (GO:0001910)2.55759134
89ribonucleoside triphosphate biosynthetic process (GO:0009201)2.55005076
90preassembly of GPI anchor in ER membrane (GO:0016254)2.52990317
91tolerance induction (GO:0002507)2.52752906
92positive regulation of humoral immune response (GO:0002922)2.51000218
93proteasome assembly (GO:0043248)2.50041610
94cellular component biogenesis (GO:0044085)2.49747780
95chaperone-mediated protein transport (GO:0072321)2.47181140
96regulation of T cell receptor signaling pathway (GO:0050856)2.46501751
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.46415493
98kynurenine metabolic process (GO:0070189)2.46388668
99positive regulation of cell killing (GO:0031343)2.46265421
100negative T cell selection (GO:0043383)2.45851123

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.16432385
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.05861239
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.88656218
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.47742756
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.25582602
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.97439926
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80803543
8VDR_22108803_ChIP-Seq_LS180_Human2.74816067
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66732840
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.53598714
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43893967
12VDR_23849224_ChIP-Seq_CD4+_Human2.42274870
13EZH2_22144423_ChIP-Seq_EOC_Human2.35366489
14ZNF274_21170338_ChIP-Seq_K562_Hela2.31019505
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.29111538
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.04186974
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01969572
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00256937
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.97523175
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.95904542
21FOXP3_21729870_ChIP-Seq_TREG_Human1.92892235
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86745638
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81168198
24MYC_18940864_ChIP-ChIP_HL60_Human1.75812587
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72195924
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.71482258
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.66509471
28ELK1_19687146_ChIP-ChIP_HELA_Human1.62348551
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58852782
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56495447
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54067184
32GATA3_26560356_Chip-Seq_TH2_Human1.51709536
33TP53_22573176_ChIP-Seq_HFKS_Human1.51297265
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50820273
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44014601
36IGF1R_20145208_ChIP-Seq_DFB_Human1.39608261
37RUNX_20019798_ChIP-Seq_JUKART_Human1.37474032
38EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33970505
39NANOG_20526341_ChIP-Seq_ESCs_Human1.33448009
40PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.31623797
41TAF2_19829295_ChIP-Seq_ESCs_Human1.29026380
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.28829042
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27707760
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.27486452
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.27041054
46AR_20517297_ChIP-Seq_VCAP_Human1.25413936
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.23002967
48RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22063072
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21895491
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20338604
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.20338604
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19971390
53MYB_26560356_Chip-Seq_TH2_Human1.19912198
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19743171
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19142358
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17846104
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17466485
58TTF2_22483619_ChIP-Seq_HELA_Human1.16167742
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15919635
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14795352
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13891502
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13701131
63BCL6_27268052_Chip-Seq_Bcells_Human1.12391641
64ER_23166858_ChIP-Seq_MCF-7_Human1.11548183
65IRF1_19129219_ChIP-ChIP_H3396_Human1.10401866
66GABP_19822575_ChIP-Seq_HepG2_Human1.10126515
67ERA_21632823_ChIP-Seq_H3396_Human1.09761401
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09313238
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06957820
70STAT1_20625510_ChIP-Seq_HELA_Human1.03520847
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03315335
72TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02648972
73EWS_26573619_Chip-Seq_HEK293_Human1.02283522
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02124302
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02076869
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01526752
77NCOR_22424771_ChIP-Seq_293T_Human1.01356132
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.01214737
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01161615
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00470075
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00449141
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99962903
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99597200
84XRN2_22483619_ChIP-Seq_HELA_Human0.99535607
85MYC_19829295_ChIP-Seq_ESCs_Human0.99535127
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.98922436
87SOX2_19829295_ChIP-Seq_ESCs_Human0.98463641
88NANOG_19829295_ChIP-Seq_ESCs_Human0.98463641
89TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97135613
90GATA3_27048872_Chip-Seq_THYMUS_Human0.96146435
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94841347
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94539702
93RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93352890
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92952237
95P300_27268052_Chip-Seq_Bcells_Human0.92891792
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.92053592
97HOXB7_26014856_ChIP-Seq_BT474_Human0.92007745
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91593635
99CTCF_20526341_ChIP-Seq_ESCs_Human0.91534356
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.91083215

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.26435693
2MP0009379_abnormal_foot_pigmentation4.04949355
3MP0001835_abnormal_antigen_presentation3.04024814
4MP0003646_muscle_fatigue2.30988251
5MP0006292_abnormal_olfactory_placode2.30021531
6MP0008877_abnormal_DNA_methylation2.15731994
7MP0001968_abnormal_touch/_nociception2.15030561
8MP0001873_stomach_inflammation2.10775888
9MP0002736_abnormal_nociception_after2.10254599
10MP0005645_abnormal_hypothalamus_physiol2.09299302
11MP0008875_abnormal_xenobiotic_pharmacok2.01496500
12MP0009785_altered_susceptibility_to1.98470525
13MP0001800_abnormal_humoral_immune1.95691540
14MP0005646_abnormal_pituitary_gland1.93678377
15MP0006072_abnormal_retinal_apoptosis1.91370680
16MP0008872_abnormal_physiological_respon1.89202567
17MP0001790_abnormal_immune_system1.84813715
18MP0005387_immune_system_phenotype1.84813715
19MP0002138_abnormal_hepatobiliary_system1.84106999
20MP0002163_abnormal_gland_morphology1.83685959
21MP0005000_abnormal_immune_tolerance1.79776834
22MP0002148_abnormal_hypersensitivity_rea1.77423408
23MP0004142_abnormal_muscle_tone1.76974180
24MP0000685_abnormal_immune_system1.75457988
25MP0000372_irregular_coat_pigmentation1.71801974
26MP0004145_abnormal_muscle_electrophysio1.70154247
27MP0003787_abnormal_imprinting1.65314785
28MP0009333_abnormal_splenocyte_physiolog1.65055965
29MP0004147_increased_porphyrin_level1.62663676
30MP0005551_abnormal_eye_electrophysiolog1.61176435
31MP0002723_abnormal_immune_serum1.58878885
32MP0002837_dystrophic_cardiac_calcinosis1.58436933
33MP0003763_abnormal_thymus_physiology1.53910967
34MP0002102_abnormal_ear_morphology1.50313659
35MP0001819_abnormal_immune_cell1.45192649
36MP0002420_abnormal_adaptive_immunity1.45091665
37MP0001986_abnormal_taste_sensitivity1.43191914
38MP0003436_decreased_susceptibility_to1.39981450
39MP0009764_decreased_sensitivity_to1.39755116
40MP0003011_delayed_dark_adaptation1.36691845
41MP0002166_altered_tumor_susceptibility1.35301539
42MP0002452_abnormal_antigen_presenting1.32591164
43MP0005075_abnormal_melanosome_morpholog1.32110291
44MP0010155_abnormal_intestine_physiology1.30861130
45MP0005025_abnormal_response_to1.29441213
46MP0003878_abnormal_ear_physiology1.27882029
47MP0005377_hearing/vestibular/ear_phenot1.27882029
48MP0003724_increased_susceptibility_to1.25166885
49MP0002933_joint_inflammation1.24058427
50MP0003866_abnormal_defecation1.22537447
51MP0002653_abnormal_ependyma_morphology1.20996617
52MP0003195_calcinosis1.19967189
53MP0008995_early_reproductive_senescence1.18144311
54MP0002876_abnormal_thyroid_physiology1.17728250
55MP0004885_abnormal_endolymph1.16953452
56MP0002006_tumorigenesis1.16092136
57MP0003806_abnormal_nucleotide_metabolis1.15688957
58MP0005379_endocrine/exocrine_gland_phen1.15162882
59MP0003786_premature_aging1.15140691
60MP0001501_abnormal_sleep_pattern1.13428539
61MP0005084_abnormal_gallbladder_morpholo1.12803209
62MP0005253_abnormal_eye_physiology1.10797542
63MP0002638_abnormal_pupillary_reflex1.01998893
64MP0001845_abnormal_inflammatory_respons1.01524442
65MP0000716_abnormal_immune_system1.00239992
66MP0002095_abnormal_skin_pigmentation0.99748363
67MP0001485_abnormal_pinna_reflex0.99238691
68MP0003880_abnormal_central_pattern0.99149126
69MP0002405_respiratory_system_inflammati0.97806694
70MP0002277_abnormal_respiratory_mucosa0.97223899
71MP0002272_abnormal_nervous_system0.97028337
72MP0002398_abnormal_bone_marrow0.94034357
73MP0008789_abnormal_olfactory_epithelium0.93705197
74MP0000631_abnormal_neuroendocrine_gland0.92790894
75MP0005410_abnormal_fertilization0.91392261
76MP0000703_abnormal_thymus_morphology0.91116787
77MP0000689_abnormal_spleen_morphology0.90924888
78MP0006036_abnormal_mitochondrial_physio0.88586897
79MP0005360_urolithiasis0.87829527
80MP0001919_abnormal_reproductive_system0.87787359
81MP0001984_abnormal_olfaction0.87751237
82MP0005389_reproductive_system_phenotype0.86171231
83MP0002234_abnormal_pharynx_morphology0.85903990
84MP0005636_abnormal_mineral_homeostasis0.85802613
85MP0003121_genomic_imprinting0.82996817
86MP0001905_abnormal_dopamine_level0.81679409
87MP0009745_abnormal_behavioral_response0.80545525
88MP0008058_abnormal_DNA_repair0.80014181
89MP0001765_abnormal_ion_homeostasis0.79842474
90MP0001970_abnormal_pain_threshold0.79223446
91MP0002722_abnormal_immune_system0.78836515
92MP0001529_abnormal_vocalization0.78307234
93MP0002429_abnormal_blood_cell0.77709680
94MP0001663_abnormal_digestive_system0.77235099
95MP0006276_abnormal_autonomic_nervous0.76934138
96MP0003718_maternal_effect0.74441447
97MP0003122_maternal_imprinting0.74270897
98MP0004133_heterotaxia0.71389406
99MP0001486_abnormal_startle_reflex0.70607299
100MP0004742_abnormal_vestibular_system0.69564083

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.10485397
2Increased hepatocellular lipid droplets (HP:0006565)4.02885952
3IgG deficiency (HP:0004315)4.00274853
4Mitochondrial inheritance (HP:0001427)3.95297528
5Lipid accumulation in hepatocytes (HP:0006561)3.83518209
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.71464316
73-Methylglutaconic aciduria (HP:0003535)3.68974585
8Abnormal mitochondria in muscle tissue (HP:0008316)3.50423791
9Type II lissencephaly (HP:0007260)3.45757672
10Increased CSF lactate (HP:0002490)3.44452679
11Pancreatic cysts (HP:0001737)3.44054344
12Acute encephalopathy (HP:0006846)3.43022566
13Renal Fanconi syndrome (HP:0001994)3.30993569
14Progressive macrocephaly (HP:0004481)3.25633847
15Abnormality of midbrain morphology (HP:0002418)3.17890696
16Molar tooth sign on MRI (HP:0002419)3.17890696
17Elevated erythrocyte sedimentation rate (HP:0003565)3.17517834
18Abnormal rod and cone electroretinograms (HP:0008323)3.17327091
19Increased intramyocellular lipid droplets (HP:0012240)3.17302659
20Reticulocytopenia (HP:0001896)3.12047282
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.06328705
22Pancreatic fibrosis (HP:0100732)3.02321449
23Congenital, generalized hypertrichosis (HP:0004540)2.96012233
24Congenital stationary night blindness (HP:0007642)2.86160481
25Abnormality of cells of the erythroid lineage (HP:0012130)2.85370736
26Hepatocellular necrosis (HP:0001404)2.80750822
27Exertional dyspnea (HP:0002875)2.80017614
28Pendular nystagmus (HP:0012043)2.75058423
29Nephronophthisis (HP:0000090)2.74587663
30Renal cortical cysts (HP:0000803)2.72547912
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.72434693
32Increased muscle lipid content (HP:0009058)2.70456722
33Abnormality of the renal cortex (HP:0011035)2.70379571
34Stomatitis (HP:0010280)2.64733059
35Abnormal number of erythroid precursors (HP:0012131)2.62893172
36Optic disc pallor (HP:0000543)2.57666726
37Asplenia (HP:0001746)2.56002095
38Medial flaring of the eyebrow (HP:0010747)2.53618274
39Increased IgM level (HP:0003496)2.52834598
40Cerebral edema (HP:0002181)2.52553467
41Aplasia/Hypoplasia of the spleen (HP:0010451)2.51622801
42True hermaphroditism (HP:0010459)2.49856190
43Hepatic necrosis (HP:0002605)2.42990421
44Abnormality of the pons (HP:0007361)2.40402564
45Aplastic anemia (HP:0001915)2.37532923
46Macrocytic anemia (HP:0001972)2.37429592
47Increased serum lactate (HP:0002151)2.35317779
48Severe combined immunodeficiency (HP:0004430)2.34811897
49Abnormality of T cells (HP:0002843)2.32583819
50Decreased central vision (HP:0007663)2.31519367
51Attenuation of retinal blood vessels (HP:0007843)2.30543882
52Abnormal drinking behavior (HP:0030082)2.30374868
53Polydipsia (HP:0001959)2.30374868
54Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27298721
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27298721
56Increased corneal curvature (HP:0100692)2.25232841
57Keratoconus (HP:0000563)2.25232841
58Abnormality of T cell physiology (HP:0011840)2.25009212
59Abnormality of the renal medulla (HP:0100957)2.22642388
60Abnormality of renal resorption (HP:0011038)2.21694108
61Lactic acidosis (HP:0003128)2.19878508
62Abolished electroretinogram (ERG) (HP:0000550)2.14811334
63Abnormality of the prostate (HP:0008775)2.12497717
64Cerebellar dysplasia (HP:0007033)2.12205322
65Hypoproteinemia (HP:0003075)2.09933765
66Pallor (HP:0000980)2.09834865
67Bile duct proliferation (HP:0001408)2.07857103
68Abnormal biliary tract physiology (HP:0012439)2.07857103
69Respiratory difficulties (HP:0002880)2.07064785
70Hypoplasia of the pons (HP:0012110)2.02604433
71T lymphocytopenia (HP:0005403)2.01807110
72Methylmalonic acidemia (HP:0002912)2.01336205
73Type 2 muscle fiber atrophy (HP:0003554)2.00957467
74Prostate neoplasm (HP:0100787)2.00838865
75Hyperphosphaturia (HP:0003109)2.00002979
76Abnormality of urine glucose concentration (HP:0011016)1.99769782
77Glycosuria (HP:0003076)1.99769782
78Hyperglycinemia (HP:0002154)1.99063571
79Concave nail (HP:0001598)1.99043810
80Pancytopenia (HP:0001876)1.98294986
81Panhypogammaglobulinemia (HP:0003139)1.96342141
82Cystic liver disease (HP:0006706)1.95753251
83Methylmalonic aciduria (HP:0012120)1.92063849
84Postaxial foot polydactyly (HP:0001830)1.89665850
85Sclerocornea (HP:0000647)1.87644842
86Leukodystrophy (HP:0002415)1.87244652
87Lethargy (HP:0001254)1.85072047
88Absent thumb (HP:0009777)1.83722716
89Abnormality of T cell number (HP:0011839)1.83529927
90Muscle fiber atrophy (HP:0100295)1.83243378
91Polyuria (HP:0000103)1.83079385
92Exercise intolerance (HP:0003546)1.82497975
93Abnormality of the renal collecting system (HP:0004742)1.79581650
94Thyroiditis (HP:0100646)1.78771071
95Anencephaly (HP:0002323)1.77168740
96Abnormality of DNA repair (HP:0003254)1.74565511
97Severe muscular hypotonia (HP:0006829)1.73365820
98Parakeratosis (HP:0001036)1.73268001
99Lissencephaly (HP:0001339)1.73139114
100Recurrent cutaneous fungal infections (HP:0011370)1.69611091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.74758280
2TLK14.35010677
3ZAK3.96786821
4MAP4K23.49479558
5WNK42.77971216
6ADRBK22.77618709
7MAP4K12.59525792
8CDK192.07206253
9GRK11.98717480
10BCKDK1.93408181
11NUAK11.92580825
12NME21.86845413
13TAOK31.80553063
14VRK21.78615852
15ITK1.67371982
16GRK61.65462673
17KDR1.62999673
18IKBKB1.62584569
19STK391.49385592
20OXSR11.43759261
21MAP3K121.43059478
22VRK11.39836611
23TEC1.38842492
24CAMKK21.36494370
25SYK1.25002830
26PRKCQ1.24744954
27NME11.23494650
28TRIM281.22498927
29BMPR21.10302078
30BTK1.08599086
31WNK31.05666533
32INSRR0.99314837
33FRK0.98855780
34TNIK0.97657724
35TIE10.96231200
36PINK10.92385537
37FES0.91979299
38LCK0.91948296
39MAP2K20.91373703
40ADRBK10.90152652
41LIMK10.88808207
42MYLK0.86277902
43LRRK20.86189001
44BMPR1B0.85813217
45PASK0.85723436
46DYRK20.85721006
47PHKG20.85670369
48PHKG10.85670369
49LYN0.84909282
50TNK20.84801217
51IKBKE0.80267896
52RPS6KA50.79124437
53STK160.75478593
54NEK10.75138174
55PIM10.74406783
56MAP2K60.72143691
57GRK70.71538831
58KIT0.71013036
59PIK3CG0.66928356
60MAP3K110.65537519
61EIF2AK20.53481739
62EIF2AK30.53449608
63CAMKK10.53421372
64PAK30.51726455
65OBSCN0.49913756
66PRKCG0.49600686
67CASK0.48917728
68PRKACA0.48569027
69DAPK10.48300358
70MUSK0.47745616
71IGF1R0.47480388
72MAPK130.46664690
73CSNK2A20.46030809
74ZAP700.45781675
75PRKCA0.45761898
76TESK20.44307837
77MST40.43847714
78CAMK10.43495101
79CSNK2A10.41712688
80DAPK30.39494730
81DAPK20.37999615
82TSSK60.37486003
83MAP3K40.37385144
84PDK20.36776587
85JAK10.36265097
86CAMK2A0.36189277
87CSK0.36030849
88TBK10.35331544
89ERBB30.34339913
90CSNK1G30.33670474
91RPS6KA40.33413058
92GRK50.33051920
93CSF1R0.32676013
94CSNK1A10.31997385
95MAPKAPK30.31364217
96RPS6KA60.29413805
97PIK3CA0.29222638
98BUB10.28395053
99PLK20.27534836
100AURKB0.27488161

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.55107440
2Oxidative phosphorylation_Homo sapiens_hsa001903.53470137
3Proteasome_Homo sapiens_hsa030503.03250118
4Primary immunodeficiency_Homo sapiens_hsa053402.97996560
5Parkinsons disease_Homo sapiens_hsa050122.88250728
6RNA polymerase_Homo sapiens_hsa030202.77880009
7Allograft rejection_Homo sapiens_hsa053302.74253788
8Asthma_Homo sapiens_hsa053102.70539392
9Autoimmune thyroid disease_Homo sapiens_hsa053202.57778980
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.45097155
11Graft-versus-host disease_Homo sapiens_hsa053322.29405998
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25633529
13Protein export_Homo sapiens_hsa030602.11989585
14Linoleic acid metabolism_Homo sapiens_hsa005911.93868699
15Alzheimers disease_Homo sapiens_hsa050101.89557021
16Huntingtons disease_Homo sapiens_hsa050161.89452748
17Type I diabetes mellitus_Homo sapiens_hsa049401.88469534
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87995066
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87698212
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85848565
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83756679
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77057384
23Cardiac muscle contraction_Homo sapiens_hsa042601.71674827
24RNA degradation_Homo sapiens_hsa030181.49554693
25Phototransduction_Homo sapiens_hsa047441.47312478
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34821161
27Caffeine metabolism_Homo sapiens_hsa002321.33075784
28Homologous recombination_Homo sapiens_hsa034401.29177029
29Nitrogen metabolism_Homo sapiens_hsa009101.28398288
30Antigen processing and presentation_Homo sapiens_hsa046121.25747071
31Pyrimidine metabolism_Homo sapiens_hsa002401.23000847
32Sulfur relay system_Homo sapiens_hsa041221.21450953
33Rheumatoid arthritis_Homo sapiens_hsa053231.19898274
34T cell receptor signaling pathway_Homo sapiens_hsa046601.18814574
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18331724
36Hematopoietic cell lineage_Homo sapiens_hsa046401.16750624
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08198985
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05521058
39Fanconi anemia pathway_Homo sapiens_hsa034600.97916244
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96606998
41Ether lipid metabolism_Homo sapiens_hsa005650.95921621
42Arachidonic acid metabolism_Homo sapiens_hsa005900.93936398
43Peroxisome_Homo sapiens_hsa041460.93866803
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90608523
45One carbon pool by folate_Homo sapiens_hsa006700.88159980
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87492478
47Purine metabolism_Homo sapiens_hsa002300.83965528
48Basal transcription factors_Homo sapiens_hsa030220.81435794
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.79866834
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79245395
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78026731
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77804065
53Propanoate metabolism_Homo sapiens_hsa006400.76488732
54Fat digestion and absorption_Homo sapiens_hsa049750.73397002
55Sulfur metabolism_Homo sapiens_hsa009200.72998491
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69365516
57Chemical carcinogenesis_Homo sapiens_hsa052040.68241031
58Butanoate metabolism_Homo sapiens_hsa006500.67759672
59Tryptophan metabolism_Homo sapiens_hsa003800.65204699
60Spliceosome_Homo sapiens_hsa030400.64791315
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64076566
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62480114
63Retinol metabolism_Homo sapiens_hsa008300.62237915
64Viral myocarditis_Homo sapiens_hsa054160.62141866
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61348069
66Olfactory transduction_Homo sapiens_hsa047400.59465304
67Regulation of autophagy_Homo sapiens_hsa041400.58251226
68Metabolic pathways_Homo sapiens_hsa011000.58048975
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55912055
70Collecting duct acid secretion_Homo sapiens_hsa049660.53979880
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.53869450
72Systemic lupus erythematosus_Homo sapiens_hsa053220.50901078
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50770777
74Nucleotide excision repair_Homo sapiens_hsa034200.50079579
75Nicotine addiction_Homo sapiens_hsa050330.49627084
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.48927398
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46535993
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.46519624
79RNA transport_Homo sapiens_hsa030130.44774233
80Morphine addiction_Homo sapiens_hsa050320.44308830
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43590035
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41894686
83Glycerolipid metabolism_Homo sapiens_hsa005610.40065021
84Taste transduction_Homo sapiens_hsa047420.39416175
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.37456770
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37353685
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.35403099
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34343759
89Measles_Homo sapiens_hsa051620.33388194
90Mineral absorption_Homo sapiens_hsa049780.30283611
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29982776
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.29266475
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28299458
94Serotonergic synapse_Homo sapiens_hsa047260.25645837
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25529550
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25064719
97Epstein-Barr virus infection_Homo sapiens_hsa051690.24817966
98Folate biosynthesis_Homo sapiens_hsa007900.24363010
99Salivary secretion_Homo sapiens_hsa049700.24232055
100Staphylococcus aureus infection_Homo sapiens_hsa051500.23677245

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