RPL11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.85025285
2* translational elongation (GO:0006414)9.13915305
3* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)9.13098636
4* cotranslational protein targeting to membrane (GO:0006613)9.00271578
5* protein targeting to ER (GO:0045047)8.97457115
6* establishment of protein localization to endoplasmic reticulum (GO:0072599)8.58617091
7* protein localization to endoplasmic reticulum (GO:0070972)8.40016000
8* cellular protein complex disassembly (GO:0043624)8.39507697
9* viral life cycle (GO:0019058)8.35165558
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)8.28964313
11maturation of SSU-rRNA (GO:0030490)7.99806833
12* translational initiation (GO:0006413)7.77536802
13* protein complex disassembly (GO:0043241)7.33549545
14* macromolecular complex disassembly (GO:0032984)6.85773276
15* ribosomal large subunit biogenesis (GO:0042273)6.40813483
16* protein targeting to membrane (GO:0006612)5.99060593
17* nuclear-transcribed mRNA catabolic process (GO:0000956)5.82211494
18* translation (GO:0006412)5.58211080
19* mRNA catabolic process (GO:0006402)5.52323774
20DNA deamination (GO:0045006)5.15356027
21* RNA catabolic process (GO:0006401)5.11354259
22* ribonucleoprotein complex biogenesis (GO:0022613)4.99982850
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.78762419
24energy coupled proton transport, down electrochemical gradient (GO:0015985)4.52500769
25ATP synthesis coupled proton transport (GO:0015986)4.52500769
26* establishment of protein localization to membrane (GO:0090150)4.07459501
27* rRNA processing (GO:0006364)4.02406828
28formation of translation preinitiation complex (GO:0001731)3.98788424
29* cellular component biogenesis (GO:0044085)3.88762118
30* rRNA metabolic process (GO:0016072)3.86784134
31* protein targeting (GO:0006605)3.77784218
32* establishment of protein localization to organelle (GO:0072594)3.69323613
33ncRNA 3-end processing (GO:0043628)3.55978056
34establishment of integrated proviral latency (GO:0075713)3.46339885
35spliceosomal snRNP assembly (GO:0000387)3.44483656
36DNA strand elongation involved in DNA replication (GO:0006271)3.41069869
37telomere maintenance via semi-conservative replication (GO:0032201)3.39072549
38spliceosomal complex assembly (GO:0000245)3.37461589
39DNA strand elongation (GO:0022616)3.20046893
40GTP biosynthetic process (GO:0006183)3.18476124
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15970940
42UTP biosynthetic process (GO:0006228)3.15071686
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.13284976
44* protein localization to membrane (GO:0072657)3.10745897
45respiratory electron transport chain (GO:0022904)3.10190004
46electron transport chain (GO:0022900)3.04226593
47termination of RNA polymerase III transcription (GO:0006386)3.01643933
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.01643933
49exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97468309
50negative regulation of RNA splicing (GO:0033119)2.97301789
51DNA unwinding involved in DNA replication (GO:0006268)2.95057111
52oxidative phosphorylation (GO:0006119)2.94392552
53* cellular component disassembly (GO:0022411)2.92873569
54heterochromatin organization (GO:0070828)2.92257799
55DNA damage response, detection of DNA damage (GO:0042769)2.92168807
56regulation of translational fidelity (GO:0006450)2.91592626
57proteasome assembly (GO:0043248)2.90497203
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90183088
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88902369
60telomere maintenance via recombination (GO:0000722)2.88668272
61establishment of viral latency (GO:0019043)2.87231985
62DNA topological change (GO:0006265)2.82218461
63myeloid cell homeostasis (GO:0002262)2.79041271
64mitotic chromosome condensation (GO:0007076)2.78320964
65ribonucleoprotein complex subunit organization (GO:0071826)2.78008342
66pseudouridine synthesis (GO:0001522)2.77838919
67DNA replication initiation (GO:0006270)2.75084276
68UTP metabolic process (GO:0046051)2.75077846
69* protein localization to organelle (GO:0033365)2.72035718
70* gene expression (GO:0010467)2.71763316
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71558267
72negative regulation of ligase activity (GO:0051352)2.71558267
73nucleotide-excision repair, DNA gap filling (GO:0006297)2.71282772
74* ncRNA processing (GO:0034470)2.70399306
75transcription-coupled nucleotide-excision repair (GO:0006283)2.70289422
76chaperone-mediated protein transport (GO:0072321)2.69895573
77mitotic recombination (GO:0006312)2.68335118
78pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.63067019
79kinetochore organization (GO:0051383)2.62495415
80CTP metabolic process (GO:0046036)2.61784142
81CTP biosynthetic process (GO:0006241)2.61784142
82positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.61425639
83telomere maintenance via telomere lengthening (GO:0010833)2.59728197
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.58575694
85histone mRNA metabolic process (GO:0008334)2.58329314
86pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.58041292
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.57429691
88kinetochore assembly (GO:0051382)2.56278073
89termination of RNA polymerase I transcription (GO:0006363)2.55942950
90guanosine-containing compound biosynthetic process (GO:1901070)2.55312439
91pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.55121176
92chromatin remodeling at centromere (GO:0031055)2.55048259
93inner mitochondrial membrane organization (GO:0007007)2.53777816
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.53727724
95ribosome biogenesis (GO:0042254)2.53154713
96pteridine-containing compound biosynthetic process (GO:0042559)2.53023397
97transcription elongation from RNA polymerase I promoter (GO:0006362)2.53015021
98ribonucleoprotein complex assembly (GO:0022618)2.51978060
99RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.51731554
100mRNA splicing, via spliceosome (GO:0000398)2.51731554
101* ncRNA metabolic process (GO:0034660)2.51250189
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.50662024
103ATP biosynthetic process (GO:0006754)2.50176864
104deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.49930188
105intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.48339855
106signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.48339855
107RNA splicing, via transesterification reactions (GO:0000375)2.46422413
108CENP-A containing nucleosome assembly (GO:0034080)2.45982728
109signal transduction involved in DNA damage checkpoint (GO:0072422)2.45234477
110signal transduction involved in DNA integrity checkpoint (GO:0072401)2.45234477
111regulation of mitochondrial translation (GO:0070129)2.41844941
112negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.41607630
113DNA replication checkpoint (GO:0000076)2.40399544
114aerobic respiration (GO:0009060)2.35382754
115purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.32587158
116protein localization to chromosome, centromeric region (GO:0071459)2.32248799
117purine nucleoside triphosphate biosynthetic process (GO:0009145)2.28582513
118* single-organism cellular localization (GO:1902580)2.27618195
119ribonucleoside triphosphate biosynthetic process (GO:0009201)2.27380138
120viral protein processing (GO:0019082)2.24723921
121positive regulation of viral transcription (GO:0050434)2.24388809
122protein targeting to mitochondrion (GO:0006626)2.21112293
123protein localization to kinetochore (GO:0034501)2.19290874
124pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.19276981
125regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.17200836
126mitotic sister chromatid segregation (GO:0000070)2.16638795
127establishment of protein localization to mitochondrion (GO:0072655)2.16625582
128negative regulation of DNA repair (GO:0045738)2.15821395
129regulation of translational initiation (GO:0006446)2.15666810
130purine nucleoside monophosphate biosynthetic process (GO:0009127)2.14477248
131purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.14477248
132termination of RNA polymerase II transcription (GO:0006369)2.11093618
133chromatin assembly or disassembly (GO:0006333)2.09593204
134* viral transcription (GO:0019083)11.2669077
135* translational termination (GO:0006415)10.8239002
136ribosomal small subunit biogenesis (GO:0042274)10.2172805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.39740099
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.34975031
3* MYC_18555785_ChIP-Seq_MESCs_Mouse5.10256866
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.26033967
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.72610174
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.47464800
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.46980637
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.32324655
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.29780859
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.08012825
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01281838
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94060463
13* XRN2_22483619_ChIP-Seq_HELA_Human2.91453424
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87190692
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83837605
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76901478
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74796732
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.62380110
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59770431
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.54551876
21* TTF2_22483619_ChIP-Seq_HELA_Human2.47598562
22VDR_23849224_ChIP-Seq_CD4+_Human2.39386063
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28949108
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26470508
25DCP1A_22483619_ChIP-Seq_HELA_Human2.22745945
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.13951034
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09145824
28* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.09101265
29FOXP3_21729870_ChIP-Seq_TREG_Human2.08719826
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08413796
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04232358
32ELK1_19687146_ChIP-ChIP_HELA_Human2.01649823
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98511073
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98127520
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91908064
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77464156
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.71853757
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70851099
39GABP_19822575_ChIP-Seq_HepG2_Human1.67238898
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66511478
41KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.66004856
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60983029
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59092764
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.58897562
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.52502080
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50408359
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48947957
48CIITA_25753668_ChIP-Seq_RAJI_Human1.46142334
49VDR_21846776_ChIP-Seq_THP-1_Human1.44204358
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43579634
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42497145
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.42187897
53MYC_18940864_ChIP-ChIP_HL60_Human1.41482743
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41380653
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40292132
56MYC_22102868_ChIP-Seq_BL_Human1.35936435
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33766999
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31374453
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.27710242
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.26676279
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26601391
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26111246
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26004655
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21968964
65AR_21909140_ChIP-Seq_LNCAP_Human1.20921143
66ZNF263_19887448_ChIP-Seq_K562_Human1.19986698
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18583051
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16061976
69CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15262154
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14881855
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14705909
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13032674
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12982475
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12936346
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.10326410
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09993023
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.09251861
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08526364
79* KDM5A_27292631_Chip-Seq_BREAST_Human1.07199820
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03337592
81OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02339154
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01551915
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01286696
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00937754
85* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00562468
86SPI1_23547873_ChIP-Seq_NB4_Human0.99653050
87NCOR1_26117541_ChIP-Seq_K562_Human0.99130381
88SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98949476
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98701959
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96952833
91KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96952833
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96952833
93* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96007859
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92417972
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90522096
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90414631
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90063179
98TET1_21451524_ChIP-Seq_MESCs_Mouse0.89961230
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89429695
100SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89349394
101FOXP1_21924763_ChIP-Seq_HESCs_Human0.89334374
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88955217
103KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87071511
104CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86999280
105ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86482655
106MAF_26560356_Chip-Seq_TH1_Human0.85637439
107* MAF_26560356_Chip-Seq_TH2_Human0.83437883
108PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83172021
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81720124
110STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81047105
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80967582
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79754660
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77366371
114IRF1_19129219_ChIP-ChIP_H3396_Human0.77161029
115TFEB_21752829_ChIP-Seq_HELA_Human0.75398022
116RBPJ_22232070_ChIP-Seq_NCS_Mouse0.74911670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.72600802
2MP0003693_abnormal_embryo_hatching3.93909759
3MP0004957_abnormal_blastocyst_morpholog3.66262441
4MP0006292_abnormal_olfactory_placode3.29344498
5MP0010094_abnormal_chromosome_stability2.77478463
6MP0003077_abnormal_cell_cycle2.72464472
7MP0000566_synostosis2.71308470
8MP0003111_abnormal_nucleus_morphology2.56392574
9MP0008932_abnormal_embryonic_tissue2.22262713
10MP0008057_abnormal_DNA_replication2.16372747
11MP0000490_abnormal_crypts_of1.91702991
12MP0002396_abnormal_hematopoietic_system1.88639525
13MP0004381_abnormal_hair_follicle1.87875955
14MP0003315_abnormal_perineum_morphology1.82485001
15MP0008007_abnormal_cellular_replicative1.81866831
16MP0010030_abnormal_orbit_morphology1.78036869
17MP0008058_abnormal_DNA_repair1.75891268
18MP0009333_abnormal_splenocyte_physiolog1.74246319
19MP0003786_premature_aging1.73478958
20MP0002102_abnormal_ear_morphology1.70733040
21MP0003136_yellow_coat_color1.66799577
22MP0003763_abnormal_thymus_physiology1.65943386
23MP0002938_white_spotting1.64444158
24MP0005174_abnormal_tail_pigmentation1.62106762
25MP0003567_abnormal_fetal_cardiomyocyte1.50963472
26MP0000350_abnormal_cell_proliferation1.45103495
27MP0002132_abnormal_respiratory_system1.43095034
28MP0005394_taste/olfaction_phenotype1.40215005
29MP0005499_abnormal_olfactory_system1.40215005
30MP0003941_abnormal_skin_development1.39323515
31MP0002697_abnormal_eye_size1.37585932
32MP0003123_paternal_imprinting1.35334242
33MP0000537_abnormal_urethra_morphology1.34237690
34MP0001730_embryonic_growth_arrest1.31358008
35MP0002009_preneoplasia1.29500329
36MP0002163_abnormal_gland_morphology1.29429021
37MP0002796_impaired_skin_barrier1.28353616
38MP0000703_abnormal_thymus_morphology1.26352776
39MP0005501_abnormal_skin_physiology1.25332244
40MP0002095_abnormal_skin_pigmentation1.22495303
41MP0000049_abnormal_middle_ear1.21966579
42MP0004808_abnormal_hematopoietic_stem1.18643929
43MP0005408_hypopigmentation1.18104918
44MP0005075_abnormal_melanosome_morpholog1.17303999
45MP0001346_abnormal_lacrimal_gland1.16114849
46MP0003984_embryonic_growth_retardation1.13893460
47MP0002398_abnormal_bone_marrow1.13540082
48MP0002722_abnormal_immune_system1.13422638
49MP0002092_abnormal_eye_morphology1.12661577
50MP0000685_abnormal_immune_system1.11957541
51MP0008789_abnormal_olfactory_epithelium1.11120439
52MP0003011_delayed_dark_adaptation1.09896537
53MP0002088_abnormal_embryonic_growth/wei1.09310284
54MP0002019_abnormal_tumor_incidence1.09069322
55MP0000678_abnormal_parathyroid_gland1.06578590
56MP0000313_abnormal_cell_death1.05606170
57MP0003718_maternal_effect1.05167783
58MP0002282_abnormal_trachea_morphology1.05140134
59MP0001697_abnormal_embryo_size1.03116004
60MP0001800_abnormal_humoral_immune1.02472696
61MP0002638_abnormal_pupillary_reflex1.02430599
62MP0002210_abnormal_sex_determination1.02065318
63MP0002080_prenatal_lethality1.00592117
64MP0000465_gastrointestinal_hemorrhage1.00059960
65MP0001727_abnormal_embryo_implantation0.97954127
66MP0000762_abnormal_tongue_morphology0.97657800
67MP0000689_abnormal_spleen_morphology0.97510518
68MP0009053_abnormal_anal_canal0.96960438
69MP0003866_abnormal_defecation0.96941230
70MP0003890_abnormal_embryonic-extraembry0.94238921
71MP0008995_early_reproductive_senescence0.93344979
72MP0006054_spinal_hemorrhage0.93170554
73MP0002085_abnormal_embryonic_tissue0.93165273
74MP0003938_abnormal_ear_development0.92941937
75MP0002429_abnormal_blood_cell0.92892231
76MP0002098_abnormal_vibrissa_morphology0.92278275
77MP0004185_abnormal_adipocyte_glucose0.92249273
78MP0000372_irregular_coat_pigmentation0.89523543
79MP0002166_altered_tumor_susceptibility0.89458367
80MP0003806_abnormal_nucleotide_metabolis0.88845109
81MP0002277_abnormal_respiratory_mucosa0.88764182
82MP0010352_gastrointestinal_tract_polyps0.88043203
83MP0002751_abnormal_autonomic_nervous0.86641729
84MP0001216_abnormal_epidermal_layer0.85174605
85MP0000716_abnormal_immune_system0.84755000
86MP0002420_abnormal_adaptive_immunity0.83296840
87MP0003959_abnormal_lean_body0.83209156
88MP0000858_altered_metastatic_potential0.83131903
89MP0001853_heart_inflammation0.82782605
90MP0001348_abnormal_lacrimal_gland0.81931399
91MP0000631_abnormal_neuroendocrine_gland0.81307819
92MP0001819_abnormal_immune_cell0.80979754
93MP0002405_respiratory_system_inflammati0.80637390
94MP0001835_abnormal_antigen_presentation0.80481589
95MP0001672_abnormal_embryogenesis/_devel0.80051524
96MP0005380_embryogenesis_phenotype0.80051524
97MP0000613_abnormal_salivary_gland0.80018902
98MP0002452_abnormal_antigen_presenting0.78994831
99MP0002249_abnormal_larynx_morphology0.78594674
100MP0005671_abnormal_response_to0.78521443
101MP0010155_abnormal_intestine_physiology0.77860803
102MP0002060_abnormal_skin_morphology0.77555740
103MP0001545_abnormal_hematopoietic_system0.77539413
104MP0005397_hematopoietic_system_phenotyp0.77539413
105MP0002084_abnormal_developmental_patter0.77241373
106MP0003937_abnormal_limbs/digits/tail_de0.76770773
107MP0000477_abnormal_intestine_morphology0.76673073
108MP0005409_darkened_coat_color0.76560593
109MP0009672_abnormal_birth_weight0.76324122
110MP0002111_abnormal_tail_morphology0.75847476
111MP0009250_abnormal_appendicular_skeleto0.75696394
112MP0000428_abnormal_craniofacial_morphol0.75661412
113MP0002148_abnormal_hypersensitivity_rea0.75575701
114MP0003186_abnormal_redox_activity0.75522568
115MP0003283_abnormal_digestive_organ0.74598733
116MP0001145_abnormal_male_reproductive0.74374105
117MP0005025_abnormal_response_to0.74152114
118MP0010307_abnormal_tumor_latency0.73755487
119MP0001286_abnormal_eye_development0.73415660
120MP0001293_anophthalmia0.73015312
121MP0002723_abnormal_immune_serum0.72937194
122MP0001873_stomach_inflammation0.72154835
123MP0002932_abnormal_joint_morphology0.71294051
124MP0003942_abnormal_urinary_system0.71206995
125MP0004197_abnormal_fetal_growth/weight/0.69487552
126MP0002160_abnormal_reproductive_system0.69159269
127MP0002233_abnormal_nose_morphology0.67160639
128MP0002653_abnormal_ependyma_morphology0.67128253
129MP0003861_abnormal_nervous_system0.66529871
130MP0006035_abnormal_mitochondrial_morpho0.66337826
131MP0001881_abnormal_mammary_gland0.66052580
132MP0006036_abnormal_mitochondrial_physio0.64028991
133MP0008961_abnormal_basal_metabolism0.64022854
134MP0003385_abnormal_body_wall0.63996896
135MP0009278_abnormal_bone_marrow0.61731539
136MP0001929_abnormal_gametogenesis0.60426004
137MP0002086_abnormal_extraembryonic_tissu0.59093249
138MP0001340_abnormal_eyelid_morphology0.58719421
139MP0001663_abnormal_digestive_system0.58164770

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.82446261
2Reticulocytopenia (HP:0001896)9.17870143
3Abnormal number of erythroid precursors (HP:0012131)8.81778877
4* Macrocytic anemia (HP:0001972)6.45881622
5* Pallor (HP:0000980)5.89992369
6Acute necrotizing encephalopathy (HP:0006965)4.00903710
7Increased hepatocellular lipid droplets (HP:0006565)3.88277468
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.83212994
9Abnormal hemoglobin (HP:0011902)3.82851611
10Mitochondrial inheritance (HP:0001427)3.80759619
11Abnormal mitochondria in muscle tissue (HP:0008316)3.53216104
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.34641315
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.34073070
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.34073070
15Lipid accumulation in hepatocytes (HP:0006561)3.31940500
16Progressive macrocephaly (HP:0004481)3.26074723
17Increased CSF lactate (HP:0002490)3.24941055
18Hepatocellular necrosis (HP:0001404)3.17723749
19Abnormality of reticulocytes (HP:0004312)3.13851851
20Exertional dyspnea (HP:0002875)3.05632526
21Acute encephalopathy (HP:0006846)3.03542933
22Colon cancer (HP:0003003)2.99372167
23Aplastic anemia (HP:0001915)2.93613065
24Renal Fanconi syndrome (HP:0001994)2.92775529
25Thrombocytosis (HP:0001894)2.92772219
2611 pairs of ribs (HP:0000878)2.89494208
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.83597924
28Increased intramyocellular lipid droplets (HP:0012240)2.73601386
29Congenital, generalized hypertrichosis (HP:0004540)2.72379305
30Absent thumb (HP:0009777)2.66579088
31Trismus (HP:0000211)2.63119113
32* Depressed nasal ridge (HP:0000457)2.62555472
33Hepatic necrosis (HP:0002605)2.61942688
34Oral leukoplakia (HP:0002745)2.58745545
35Respiratory difficulties (HP:0002880)2.52831599
36Concave nail (HP:0001598)2.52785985
37Abnormality of the parietal bone (HP:0002696)2.47245704
38Carpal bone hypoplasia (HP:0001498)2.40477677
39Stenosis of the external auditory canal (HP:0000402)2.39682453
40Woolly hair (HP:0002224)2.37465756
41Multiple enchondromatosis (HP:0005701)2.35017468
42Exercise intolerance (HP:0003546)2.31195194
43Duplication of thumb phalanx (HP:0009942)2.31096983
443-Methylglutaconic aciduria (HP:0003535)2.30448352
45Abnormality of cochlea (HP:0000375)2.29362327
46Increased serum lactate (HP:0002151)2.26824471
47Breast hypoplasia (HP:0003187)2.25387521
48Septo-optic dysplasia (HP:0100842)2.22088941
49Increased muscle lipid content (HP:0009058)2.19968342
50Morphological abnormality of the inner ear (HP:0011390)2.19805846
51* Thick lower lip vermilion (HP:0000179)2.16859152
52Respiratory failure (HP:0002878)2.16706818
53Fragile nails (HP:0001808)2.16169327
54Microvesicular hepatic steatosis (HP:0001414)2.15869887
55Nasolacrimal duct obstruction (HP:0000579)2.13626383
56IgM deficiency (HP:0002850)2.13477405
57* Migraine (HP:0002076)2.13459652
58Hypoplasia of the radius (HP:0002984)2.12883839
59Selective tooth agenesis (HP:0001592)2.10254920
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.07390602
61Poikiloderma (HP:0001029)2.05895647
62Rough bone trabeculation (HP:0100670)2.02708363
63Chromsome breakage (HP:0040012)2.02114377
64Asplenia (HP:0001746)2.01430783
65Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01142135
66Glossoptosis (HP:0000162)1.99140414
67Abnormality of the axillary hair (HP:0100134)1.98209908
68Abnormality of secondary sexual hair (HP:0009888)1.98209908
69Partial duplication of the phalanx of hand (HP:0009999)1.97231512
70Cleft eyelid (HP:0000625)1.92538178
71Partial duplication of thumb phalanx (HP:0009944)1.91464376
72Cerebral edema (HP:0002181)1.91271466
73Abnormal number of incisors (HP:0011064)1.89999289
74Patellar aplasia (HP:0006443)1.89122197
75Optic disc pallor (HP:0000543)1.87478338
76Abnormality of DNA repair (HP:0003254)1.87229193
77* Triphalangeal thumb (HP:0001199)1.86838141
78Aplasia/Hypoplasia of the patella (HP:0006498)1.86050980
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.85200889
80Abnormality of placental membranes (HP:0011409)1.84915267
81Amniotic constriction ring (HP:0009775)1.84915267
82Rib fusion (HP:0000902)1.83658949
83Panhypogammaglobulinemia (HP:0003139)1.83384386
84Lactic acidosis (HP:0003128)1.80817344
85Maternal diabetes (HP:0009800)1.78301638
86Deep palmar crease (HP:0006191)1.77568502
87Atresia of the external auditory canal (HP:0000413)1.77237307
88Microretrognathia (HP:0000308)1.74830757
89Aplasia/Hypoplasia of the thymus (HP:0010515)1.74342250
90Broad distal phalanx of finger (HP:0009836)1.73835632
91Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73467820
92Missing ribs (HP:0000921)1.73255474
93Abnormality of the lacrimal duct (HP:0011481)1.73047775
94Leukodystrophy (HP:0002415)1.72500194
95Truncus arteriosus (HP:0001660)1.70938681
96Progressive muscle weakness (HP:0003323)1.70342156
97Sparse eyelashes (HP:0000653)1.69921116
98Ridged nail (HP:0001807)1.67800382
99Colitis (HP:0002583)1.66401447
100Hyperphosphaturia (HP:0003109)1.64527394
101Absent radius (HP:0003974)1.64314838
102Parakeratosis (HP:0001036)1.63163307
103Hypertensive crisis (HP:0100735)1.62789012
104Sparse lateral eyebrow (HP:0005338)1.62354867
105Congenital ichthyosiform erythroderma (HP:0007431)1.61184546
106Seborrheic dermatitis (HP:0001051)1.60760634
107Abnormality of the heme biosynthetic pathway (HP:0010472)1.60306867
108Secondary amenorrhea (HP:0000869)1.60171006
109Neoplasm of the pancreas (HP:0002894)1.59850842
110Pancytopenia (HP:0001876)1.59141146
111Reticulocytosis (HP:0001923)1.58757231
112Birth length less than 3rd percentile (HP:0003561)1.58692669
113Agammaglobulinemia (HP:0004432)1.58231555
114Abnormality of the preputium (HP:0100587)1.57939202
115Premature skin wrinkling (HP:0100678)1.57575555
116Abnormality of renal resorption (HP:0011038)1.55566172
117Premature graying of hair (HP:0002216)1.55363705
118Aplasia/hypoplasia of the uterus (HP:0008684)1.54752730
119Elevated erythrocyte sedimentation rate (HP:0003565)1.53781699
120Abnormality of the nasolacrimal system (HP:0000614)1.53471667
121Myelodysplasia (HP:0002863)1.53329220
122Absent septum pellucidum (HP:0001331)1.52584332
123B lymphocytopenia (HP:0010976)1.51383294
124Abnormality of B cell number (HP:0010975)1.51383294
125Abnormality of the renal collecting system (HP:0004742)1.51112125
126Aplasia involving forearm bones (HP:0009822)1.50846828
127Villous atrophy (HP:0011473)1.47998798
128Abnormality of small intestinal villus morphology (HP:0011472)1.47998798
129Duplicated collecting system (HP:0000081)1.46675079
130Metaphyseal cupping (HP:0003021)1.46173662
131Gastrointestinal stroma tumor (HP:0100723)1.44788494
132Irregular epiphyses (HP:0010582)1.44600815
133Short middle phalanx of the 5th finger (HP:0004220)1.44596372
134* Short nose (HP:0003196)1.43912730
135Hypoparathyroidism (HP:0000829)1.43535458
136Supernumerary ribs (HP:0005815)1.42181919
137Neoplasm of head and neck (HP:0012288)1.41226172
138Esophageal neoplasm (HP:0100751)1.41226172
139Esophageal atresia (HP:0002032)1.41038300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.15203441
2TLK14.53538523
3BUB13.81765017
4WEE13.03650005
5VRK22.79851348
6STK162.57848804
7RPS6KB22.47153273
8SRPK12.38375630
9LRRK22.34854601
10TESK22.14381531
11EIF2AK12.10536130
12VRK12.06184044
13EEF2K1.95084803
14PIM21.92175996
15TGFBR11.87378662
16PRPF4B1.82799307
17SMG11.82635340
18MST41.80393220
19DYRK31.76192278
20CDC71.72560420
21NME11.61126975
22MKNK11.53127926
23CDK191.52666380
24PASK1.50360026
25NEK21.46428742
26MAP4K11.45515412
27TRIB31.43745787
28ILK1.40459895
29ACVR1B1.38274029
30AURKB1.38136580
31CDK121.36247960
32MAP3K101.32328831
33CDK71.25306586
34EIF2AK31.17110980
35TYRO31.13473969
36TSSK61.13185708
37MKNK21.10943769
38PLK11.03303023
39BLK1.02738105
40MAPK151.01650895
41AURKA1.01304596
42STK101.00504382
43PBK0.99887210
44KDR0.99382207
45BTK0.97918470
46FLT30.97416519
47NEK10.97162734
48TEC0.94703678
49BRSK20.93055090
50RPS6KA40.92214875
51PAK40.91877241
52DAPK30.90676868
53CSNK2A20.90253397
54GRK60.88004063
55MAPKAPK30.87541403
56RPS6KA50.86759400
57MAP3K80.86630423
58RIPK40.86547189
59ICK0.84904389
60STK240.83260549
61ZAK0.82342819
62TTK0.82079757
63MAP3K130.81577007
64ATR0.81270323
65MAP2K20.79621168
66TAF10.78275892
67CDK80.78198407
68CSNK2A10.76688545
69CDK40.75743226
70PAK10.74732564
71WNK40.74118068
72SIK10.70497244
73PIM10.67951056
74DYRK20.66116997
75IRAK40.65210200
76BRSK10.63006602
77EPHA20.62886174
78LIMK10.62327539
79IKBKB0.62313394
80PTK60.60882225
81MAP3K110.58674996
82MAPKAPK50.58288651
83PAK20.58217004
84PKN20.58187720
85EPHB20.57762422
86CLK10.57521940
87KSR20.57209357
88ITK0.55616613
89STK40.55198657
90PLK40.54179349
91NLK0.53481700
92TESK10.53335850
93KIT0.53106652
94CHEK20.51208818
95EIF2AK20.50877246
96SYK0.50475844
97RPS6KA10.50055873
98PRKCI0.49989734
99UHMK10.49204111
100CDK10.48839361
101CSNK1E0.48700820
102MARK30.48289589
103ZAP700.48208288
104FGFR40.47607597
105BRD40.47333914
106ALK0.47178340
107CHEK10.46230136
108SIK20.44836819
109LCK0.44449452
110LYN0.44432898
111CDK30.44082738
112ARAF0.43144978
113ADRBK10.43094841
114MST1R0.42783162
115CSF1R0.42272604
116CDK60.41852089
117LATS20.41468100
118PNCK0.40337321
119MAPK40.39343780
120CSNK1G30.38042999
121CDK11A0.37956820
122RPS6KL10.37059690
123RPS6KC10.37059690
124JAK30.36963532
125CDK90.36538391
126TYK20.36170016
127DYRK1B0.35248136
128IRAK30.35218198
129MYLK0.34475111
130AKT10.34440219
131MAP3K30.33776853
132MTOR0.33490308
133* CDK20.32774495
134ATM0.32769664
135SCYL20.32612780
136RPS6KB10.32363157
137RPS6KA60.31629326
138BRAF0.31561487
139ABL20.31239955

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030108.48022416
2DNA replication_Homo sapiens_hsa030303.54022549
3RNA polymerase_Homo sapiens_hsa030203.25370255
4Proteasome_Homo sapiens_hsa030503.24277678
5Oxidative phosphorylation_Homo sapiens_hsa001903.06817262
6Mismatch repair_Homo sapiens_hsa034302.99004928
7Spliceosome_Homo sapiens_hsa030402.95165875
8Parkinsons disease_Homo sapiens_hsa050122.88897975
9Homologous recombination_Homo sapiens_hsa034402.47922784
10Nucleotide excision repair_Homo sapiens_hsa034202.27475624
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22210056
12Pyrimidine metabolism_Homo sapiens_hsa002402.22205364
13Huntingtons disease_Homo sapiens_hsa050162.18815663
14Protein export_Homo sapiens_hsa030601.97030483
15Alzheimers disease_Homo sapiens_hsa050101.96874816
16Base excision repair_Homo sapiens_hsa034101.94888637
17RNA transport_Homo sapiens_hsa030131.93732612
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90742336
19One carbon pool by folate_Homo sapiens_hsa006701.52772498
20Fanconi anemia pathway_Homo sapiens_hsa034601.39373786
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.37716793
22Sulfur relay system_Homo sapiens_hsa041221.36455510
23RNA degradation_Homo sapiens_hsa030181.35683784
24Cell cycle_Homo sapiens_hsa041101.34686116
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32304929
26Non-homologous end-joining_Homo sapiens_hsa034501.32267983
27Systemic lupus erythematosus_Homo sapiens_hsa053221.27645889
28Basal transcription factors_Homo sapiens_hsa030221.24937214
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23684912
30Primary immunodeficiency_Homo sapiens_hsa053401.07425933
31Purine metabolism_Homo sapiens_hsa002301.01432743
32p53 signaling pathway_Homo sapiens_hsa041150.96938369
33Cardiac muscle contraction_Homo sapiens_hsa042600.90225406
34Epstein-Barr virus infection_Homo sapiens_hsa051690.87335181
35mRNA surveillance pathway_Homo sapiens_hsa030150.83375173
36Antigen processing and presentation_Homo sapiens_hsa046120.79488104
37Glutathione metabolism_Homo sapiens_hsa004800.71789987
38Folate biosynthesis_Homo sapiens_hsa007900.71028373
39Biosynthesis of amino acids_Homo sapiens_hsa012300.67959208
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66579345
41Pentose phosphate pathway_Homo sapiens_hsa000300.63753373
42Herpes simplex infection_Homo sapiens_hsa051680.60926691
43Viral carcinogenesis_Homo sapiens_hsa052030.57912902
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55131511
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55029041
46Hematopoietic cell lineage_Homo sapiens_hsa046400.54042015
47Alcoholism_Homo sapiens_hsa050340.53225796
48Thyroid cancer_Homo sapiens_hsa052160.52262239
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51465092
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49493022
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49111913
52Carbon metabolism_Homo sapiens_hsa012000.48890103
53Basal cell carcinoma_Homo sapiens_hsa052170.47733295
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46430151
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46426980
56HTLV-I infection_Homo sapiens_hsa051660.46412980
57Pancreatic cancer_Homo sapiens_hsa052120.45625693
58Non-small cell lung cancer_Homo sapiens_hsa052230.45608148
59Arachidonic acid metabolism_Homo sapiens_hsa005900.43141854
60Metabolic pathways_Homo sapiens_hsa011000.37632530
61Small cell lung cancer_Homo sapiens_hsa052220.35777086
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.35362165
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35357394
64Asthma_Homo sapiens_hsa053100.35291559
65Pyruvate metabolism_Homo sapiens_hsa006200.35066470
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31251383
67Renal cell carcinoma_Homo sapiens_hsa052110.31069782
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30750186
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30285096
70Allograft rejection_Homo sapiens_hsa053300.29268538
71Bladder cancer_Homo sapiens_hsa052190.28975887
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27759481
73Apoptosis_Homo sapiens_hsa042100.27082748
74Selenocompound metabolism_Homo sapiens_hsa004500.26824672
75Measles_Homo sapiens_hsa051620.26819963
76VEGF signaling pathway_Homo sapiens_hsa043700.26668540
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.26158562
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.25477546
79Notch signaling pathway_Homo sapiens_hsa043300.25466993
80Hedgehog signaling pathway_Homo sapiens_hsa043400.24248048
81Linoleic acid metabolism_Homo sapiens_hsa005910.24141057
82Vitamin digestion and absorption_Homo sapiens_hsa049770.23997666
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23873316
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.23210203
85Leishmaniasis_Homo sapiens_hsa051400.22276998
86Pathways in cancer_Homo sapiens_hsa052000.21473784
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21299796
88Legionellosis_Homo sapiens_hsa051340.21087325
89N-Glycan biosynthesis_Homo sapiens_hsa005100.20988630
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.20684440
91Prostate cancer_Homo sapiens_hsa052150.19880658
92MicroRNAs in cancer_Homo sapiens_hsa052060.19529338
93Acute myeloid leukemia_Homo sapiens_hsa052210.19048662
94TGF-beta signaling pathway_Homo sapiens_hsa043500.18586717
95B cell receptor signaling pathway_Homo sapiens_hsa046620.18245397
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18156097
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17196136
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16843932
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.16395156
100Influenza A_Homo sapiens_hsa051640.16347524
101Fat digestion and absorption_Homo sapiens_hsa049750.15791735
102Autoimmune thyroid disease_Homo sapiens_hsa053200.14360176
103Hepatitis B_Homo sapiens_hsa051610.14256920
104Oocyte meiosis_Homo sapiens_hsa041140.14023981
105Fructose and mannose metabolism_Homo sapiens_hsa000510.14014824
106Viral myocarditis_Homo sapiens_hsa054160.13763504
107Graft-versus-host disease_Homo sapiens_hsa053320.13257818
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.12818680
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12297642
110T cell receptor signaling pathway_Homo sapiens_hsa046600.11308851
111Tyrosine metabolism_Homo sapiens_hsa003500.11113526
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09634664
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09190787
114Shigellosis_Homo sapiens_hsa051310.08937572
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.08829940
116HIF-1 signaling pathway_Homo sapiens_hsa040660.07890567
117Colorectal cancer_Homo sapiens_hsa052100.07536312
118Renin-angiotensin system_Homo sapiens_hsa046140.07226566
119Wnt signaling pathway_Homo sapiens_hsa043100.06822542
120Chronic myeloid leukemia_Homo sapiens_hsa052200.06722406
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.06619407

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