RPL11P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.11880669
2translational termination (GO:0006415)6.74156473
3ribosomal small subunit assembly (GO:0000028)6.67950689
4behavioral response to nicotine (GO:0035095)6.22562279
5translational elongation (GO:0006414)5.74520404
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.61602568
7cotranslational protein targeting to membrane (GO:0006613)5.55737788
8protein targeting to ER (GO:0045047)5.52589416
9establishment of protein localization to endoplasmic reticulum (GO:0072599)5.28008213
10ribosomal small subunit biogenesis (GO:0042274)5.22459920
11protein localization to endoplasmic reticulum (GO:0070972)5.20085387
12viral life cycle (GO:0019058)5.11964325
13cellular protein complex disassembly (GO:0043624)4.98750962
14GTP biosynthetic process (GO:0006183)4.90380526
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.73991659
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.65024232
17ATP synthesis coupled proton transport (GO:0015986)4.65024232
18protein neddylation (GO:0045116)4.63199065
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.49863110
20negative regulation of T cell differentiation in thymus (GO:0033085)4.42457461
21maturation of SSU-rRNA (GO:0030490)4.40166051
22translational initiation (GO:0006413)4.33755559
23UTP biosynthetic process (GO:0006228)4.29223047
24cell proliferation in forebrain (GO:0021846)4.24987463
25protein complex disassembly (GO:0043241)4.16090843
26regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.15761243
27ribosomal large subunit biogenesis (GO:0042273)4.11349028
28UTP metabolic process (GO:0046051)3.99115185
29positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.96998267
30macromolecular complex disassembly (GO:0032984)3.90964303
31synaptic transmission, cholinergic (GO:0007271)3.62655349
32protein targeting to membrane (GO:0006612)3.61750992
33regulation of immunoglobulin secretion (GO:0051023)3.58104634
34ribonucleoprotein complex biogenesis (GO:0022613)3.57576126
35epithelial cilium movement (GO:0003351)3.54486287
36rRNA catabolic process (GO:0016075)3.54282346
37purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.50594785
38translation (GO:0006412)3.45124632
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.44197438
40purine nucleoside triphosphate biosynthetic process (GO:0009145)3.39675307
41coenzyme catabolic process (GO:0009109)3.35529339
42water-soluble vitamin biosynthetic process (GO:0042364)3.34238133
43CTP biosynthetic process (GO:0006241)3.33138608
44CTP metabolic process (GO:0046036)3.33138608
45regulation of isotype switching to IgG isotypes (GO:0048302)3.32587041
46nuclear-transcribed mRNA catabolic process (GO:0000956)3.30341843
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.27817174
48mRNA catabolic process (GO:0006402)3.14288235
49cellular component biogenesis (GO:0044085)3.13316306
50multicellular organism reproduction (GO:0032504)3.12125866
51DNA deamination (GO:0045006)3.11139359
52negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.09449706
53ATP biosynthetic process (GO:0006754)3.06451920
54ribonucleoside triphosphate biosynthetic process (GO:0009201)3.03640403
55pattern specification involved in kidney development (GO:0061004)2.98471202
56pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.97704979
57electron transport chain (GO:0022900)2.96789186
58respiratory electron transport chain (GO:0022904)2.96622040
59response to pheromone (GO:0019236)2.94332020
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89606013
61pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.88909065
62neurofilament cytoskeleton organization (GO:0060052)2.88353495
63positive regulation of prostaglandin secretion (GO:0032308)2.87531743
64regulation of regulatory T cell differentiation (GO:0045589)2.87221340
65protein complex biogenesis (GO:0070271)2.86083446
66nucleoside diphosphate phosphorylation (GO:0006165)2.85926505
67hypothalamus development (GO:0021854)2.85805262
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.83180291
69negative regulation of macrophage differentiation (GO:0045650)2.82575623
70ribosome biogenesis (GO:0042254)2.82480193
71pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.82442242
72hydrogen ion transmembrane transport (GO:1902600)2.81665152
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81345377
74pyrimidine nucleotide catabolic process (GO:0006244)2.78792377
75regulation of T cell differentiation in thymus (GO:0033081)2.77127142
76one-carbon compound transport (GO:0019755)2.74132753
77transmission of nerve impulse (GO:0019226)2.73001509
78positive regulation of fatty acid transport (GO:2000193)2.72629815
79pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72190007
80RNA catabolic process (GO:0006401)2.72043025
81phosphatidylserine acyl-chain remodeling (GO:0036150)2.71880332
82piRNA metabolic process (GO:0034587)2.70723246
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67745808
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67745808
85phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.66750199
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66647844
87response to xenobiotic stimulus (GO:0009410)2.65095576
88proton transport (GO:0015992)2.64900382
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.63741973
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63008706
91maturation of 5.8S rRNA (GO:0000460)2.61716104
92positive regulation of T cell apoptotic process (GO:0070234)2.61597124
93hydrogen transport (GO:0006818)2.59820842
94proteasome assembly (GO:0043248)2.58623883
95somite development (GO:0061053)2.55795558
96mitochondrial respiratory chain complex I assembly (GO:0032981)2.55333300
97NADH dehydrogenase complex assembly (GO:0010257)2.55333300
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55333300
99head development (GO:0060322)2.55001344
100negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.52706288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.77522889
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.87353118
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.62729345
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.57999875
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.50421944
6ZNF274_21170338_ChIP-Seq_K562_Hela2.44154760
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36326389
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34153730
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.24016639
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21740349
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14703937
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13039546
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02748456
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.98758311
15BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97386949
16SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93793497
17VDR_22108803_ChIP-Seq_LS180_Human1.91783885
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87061081
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.86979766
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.84187879
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.80595560
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.77908420
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72199769
24REST_21632747_ChIP-Seq_MESCs_Mouse1.72129128
25MYC_18940864_ChIP-ChIP_HL60_Human1.67142347
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59692382
27ETV2_25802403_ChIP-Seq_MESCs_Mouse1.56963012
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54690165
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53534401
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53024796
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52812497
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.50024023
33GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.48685108
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47459035
35IRF1_19129219_ChIP-ChIP_H3396_Human1.46857817
36NCOR_22424771_ChIP-Seq_293T_Human1.43405544
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42672234
38NANOG_20526341_ChIP-Seq_ESCs_Human1.37802495
39TAF2_19829295_ChIP-Seq_ESCs_Human1.33679231
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32480406
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30650410
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30650410
43CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.30302828
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.29464389
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29174269
46CBP_20019798_ChIP-Seq_JUKART_Human1.28662624
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28662624
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26796472
49VDR_23849224_ChIP-Seq_CD4+_Human1.26188985
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25354736
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.24667702
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23909124
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.23840604
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20973383
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20731458
56P300_19829295_ChIP-Seq_ESCs_Human1.20459999
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20022504
58ERA_21632823_ChIP-Seq_H3396_Human1.19497819
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18945607
60TP53_22573176_ChIP-Seq_HFKS_Human1.18445819
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18417669
62RNF2_27304074_Chip-Seq_NSC_Mouse1.17911744
63MYC_19829295_ChIP-Seq_ESCs_Human1.16824754
64EWS_26573619_Chip-Seq_HEK293_Human1.16760042
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15879862
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11543887
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11140464
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.11140464
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10797963
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10007238
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09147475
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08577773
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08368258
74CTCF_27219007_Chip-Seq_Bcells_Human1.08305537
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07430426
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05299732
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04571426
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.04178547
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03665250
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02725176
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.02492674
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01834085
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01609525
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99184010
85FOXP3_21729870_ChIP-Seq_TREG_Human0.99061066
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.98927207
87YY1_21170310_ChIP-Seq_MESCs_Mouse0.96999331
88P53_21459846_ChIP-Seq_SAOS-2_Human0.96832451
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96439476
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95976974
91FUS_26573619_Chip-Seq_HEK293_Human0.95635809
92CTCF_20526341_ChIP-Seq_ESCs_Human0.95368083
93NANOG_19829295_ChIP-Seq_ESCs_Human0.95073302
94SOX2_19829295_ChIP-Seq_ESCs_Human0.95073302
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94704297
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94356301
97TTF2_22483619_ChIP-Seq_HELA_Human0.93519416
98AR_20517297_ChIP-Seq_VCAP_Human0.92987890
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92358362
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.90180459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.64933020
2MP0009379_abnormal_foot_pigmentation3.31736121
3MP0003787_abnormal_imprinting3.28889480
4MP0003011_delayed_dark_adaptation3.22531622
5MP0004147_increased_porphyrin_level2.77189573
6MP0002638_abnormal_pupillary_reflex2.72529383
7MP0004885_abnormal_endolymph2.60729522
8MP0003122_maternal_imprinting2.39579210
9MP0002163_abnormal_gland_morphology2.27290668
10MP0005645_abnormal_hypothalamus_physiol2.27113585
11MP0003646_muscle_fatigue2.17484503
12MP0002102_abnormal_ear_morphology2.16885900
13MP0004142_abnormal_muscle_tone2.10844258
14MP0002138_abnormal_hepatobiliary_system2.03711313
15MP0001968_abnormal_touch/_nociception2.00073030
16MP0002653_abnormal_ependyma_morphology1.96930682
17MP0005646_abnormal_pituitary_gland1.95579511
18MP0008877_abnormal_DNA_methylation1.92639945
19MP0005423_abnormal_somatic_nervous1.86768641
20MP0006276_abnormal_autonomic_nervous1.85429733
21MP0003121_genomic_imprinting1.80896721
22MP0004145_abnormal_muscle_electrophysio1.71920220
23MP0004742_abnormal_vestibular_system1.67579531
24MP0002837_dystrophic_cardiac_calcinosis1.60634865
25MP0002733_abnormal_thermal_nociception1.60225184
26MP0000631_abnormal_neuroendocrine_gland1.57560335
27MP0005377_hearing/vestibular/ear_phenot1.57185926
28MP0003878_abnormal_ear_physiology1.57185926
29MP0002272_abnormal_nervous_system1.56822598
30MP0005379_endocrine/exocrine_gland_phen1.53196870
31MP0009745_abnormal_behavioral_response1.49051951
32MP0005551_abnormal_eye_electrophysiolog1.47309626
33MP0001440_abnormal_grooming_behavior1.47057959
34MP0001188_hyperpigmentation1.46456835
35MP0005389_reproductive_system_phenotype1.39323922
36MP0000566_synostosis1.39315296
37MP0001970_abnormal_pain_threshold1.37521522
38MP0002822_catalepsy1.37288043
39MP0002160_abnormal_reproductive_system1.36552439
40MP0001293_anophthalmia1.36468473
41MP0001919_abnormal_reproductive_system1.35755437
42MP0005253_abnormal_eye_physiology1.35354708
43MP0003879_abnormal_hair_cell1.32126393
44MP0003123_paternal_imprinting1.31553315
45MP0008875_abnormal_xenobiotic_pharmacok1.30622830
46MP0002277_abnormal_respiratory_mucosa1.28016026
47MP0002736_abnormal_nociception_after1.27525139
48MP0002876_abnormal_thyroid_physiology1.24251750
49MP0000049_abnormal_middle_ear1.19539353
50MP0005671_abnormal_response_to1.19449923
51MP0002063_abnormal_learning/memory/cond1.16585453
52MP0003635_abnormal_synaptic_transmissio1.16359961
53MP0001905_abnormal_dopamine_level1.15215743
54MP0002557_abnormal_social/conspecific_i1.13257883
55MP0002184_abnormal_innervation1.12631461
56MP0002572_abnormal_emotion/affect_behav1.11721331
57MP0000955_abnormal_spinal_cord1.10121535
58MP0002234_abnormal_pharynx_morphology1.09594593
59MP0000372_irregular_coat_pigmentation1.09222748
60MP0008789_abnormal_olfactory_epithelium1.08769110
61MP0001986_abnormal_taste_sensitivity1.08390077
62MP0005410_abnormal_fertilization1.08180087
63MP0001835_abnormal_antigen_presentation1.06016649
64MP0000778_abnormal_nervous_system1.03863568
65MP0001984_abnormal_olfaction1.02383026
66MP0002752_abnormal_somatic_nervous1.01848141
67MP0004133_heterotaxia1.00056705
68MP0002067_abnormal_sensory_capabilities1.00020602
69MP0003880_abnormal_central_pattern0.96471839
70MP0002938_white_spotting0.96143502
71MP0006072_abnormal_retinal_apoptosis0.95351796
72MP0008872_abnormal_physiological_respon0.95133147
73MP0001485_abnormal_pinna_reflex0.90605355
74MP0000026_abnormal_inner_ear0.90252872
75MP0008775_abnormal_heart_ventricle0.89139633
76MP0004130_abnormal_muscle_cell0.88467265
77MP0001963_abnormal_hearing_physiology0.86509899
78MP0003866_abnormal_defecation0.85931349
79MP0005394_taste/olfaction_phenotype0.85756418
80MP0005499_abnormal_olfactory_system0.85756418
81MP0005195_abnormal_posterior_eye0.84123853
82MP0005167_abnormal_blood-brain_barrier0.83596888
83MP0001663_abnormal_digestive_system0.81895305
84MP0001529_abnormal_vocalization0.81737378
85MP0003890_abnormal_embryonic-extraembry0.80539820
86MP0002735_abnormal_chemical_nociception0.79855173
87MP0003136_yellow_coat_color0.78832175
88MP0004019_abnormal_vitamin_homeostasis0.77998825
89MP0003936_abnormal_reproductive_system0.75717243
90MP0004859_abnormal_synaptic_plasticity0.75050708
91MP0001486_abnormal_startle_reflex0.71759233
92MP0002210_abnormal_sex_determination0.69862156
93MP0003937_abnormal_limbs/digits/tail_de0.69819349
94MP0005391_vision/eye_phenotype0.69569474
95MP0002882_abnormal_neuron_morphology0.69456389
96MP0003938_abnormal_ear_development0.69110390
97MP0001664_abnormal_digestion0.67723975
98MP0002229_neurodegeneration0.67203651
99MP0002064_seizures0.65524684
100MP0009053_abnormal_anal_canal0.63681224

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)6.07815893
2Abnormal rod and cone electroretinograms (HP:0008323)4.83141029
33-Methylglutaconic aciduria (HP:0003535)4.16520725
4Increased hepatocellular lipid droplets (HP:0006565)3.78536067
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.72928330
6Absent/shortened dynein arms (HP:0200106)3.72928330
7Abnormality of cells of the erythroid lineage (HP:0012130)3.72393227
8Lipid accumulation in hepatocytes (HP:0006561)3.45123075
9Renal Fanconi syndrome (HP:0001994)3.43732235
10Acute necrotizing encephalopathy (HP:0006965)3.39730374
11Pancreatic cysts (HP:0001737)3.33251883
12Abnormality of midbrain morphology (HP:0002418)3.17256455
13Molar tooth sign on MRI (HP:0002419)3.17256455
14Pancreatic fibrosis (HP:0100732)3.11662674
15Bile duct proliferation (HP:0001408)3.07380647
16Abnormal biliary tract physiology (HP:0012439)3.07380647
17Acute encephalopathy (HP:0006846)3.07182115
18Aplasia/Hypoplasia of the spleen (HP:0010451)3.01009315
19Stomatitis (HP:0010280)2.99337545
20Asplenia (HP:0001746)2.98004731
21Mitochondrial inheritance (HP:0001427)2.97098762
22Abnormal mitochondria in muscle tissue (HP:0008316)2.93558553
23Congenital stationary night blindness (HP:0007642)2.93378997
24Abnormal number of erythroid precursors (HP:0012131)2.91555008
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.88656151
26Abnormality of renal resorption (HP:0011038)2.83964956
27Reticulocytopenia (HP:0001896)2.83632363
28Type 2 muscle fiber atrophy (HP:0003554)2.80380001
29Nephronophthisis (HP:0000090)2.79944734
30Progressive macrocephaly (HP:0004481)2.79296953
31Macrocytic anemia (HP:0001972)2.78883693
32Decreased central vision (HP:0007663)2.74350714
33Increased intramyocellular lipid droplets (HP:0012240)2.73568077
34Abnormal respiratory motile cilium morphology (HP:0005938)2.70909654
35Abnormal respiratory epithelium morphology (HP:0012253)2.70909654
36Septo-optic dysplasia (HP:0100842)2.69413839
37Attenuation of retinal blood vessels (HP:0007843)2.66383109
38Abnormality of the labia minora (HP:0012880)2.64707635
39True hermaphroditism (HP:0010459)2.59928153
40Exertional dyspnea (HP:0002875)2.54083900
41Abolished electroretinogram (ERG) (HP:0000550)2.50814957
42Type II lissencephaly (HP:0007260)2.49281531
43Abnormal respiratory motile cilium physiology (HP:0012261)2.49247839
44Muscle fiber atrophy (HP:0100295)2.48762552
45Optic disc pallor (HP:0000543)2.48396268
46Cerebral edema (HP:0002181)2.45614299
47Pendular nystagmus (HP:0012043)2.40178679
48Abnormality of the renal medulla (HP:0100957)2.38681072
49Abnormal ciliary motility (HP:0012262)2.38404660
50Absent thumb (HP:0009777)2.36393627
51IgG deficiency (HP:0004315)2.34195604
52Supernumerary spleens (HP:0009799)2.32708926
53Increased CSF lactate (HP:0002490)2.32343598
54Increased muscle lipid content (HP:0009058)2.31867489
55Stenosis of the external auditory canal (HP:0000402)2.29854584
56Agitation (HP:0000713)2.20882539
57Oligodactyly (hands) (HP:0001180)2.20089284
58Pallor (HP:0000980)2.19609022
59Respiratory difficulties (HP:0002880)2.15986284
60Optic nerve hypoplasia (HP:0000609)2.15461927
61Cystic liver disease (HP:0006706)2.09315990
62Chronic hepatic failure (HP:0100626)2.08257684
63Elevated erythrocyte sedimentation rate (HP:0003565)2.06537778
64Abnormality of the renal cortex (HP:0011035)2.03764758
65Hyperthyroidism (HP:0000836)2.03180588
66Congenital, generalized hypertrichosis (HP:0004540)2.02406557
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01466783
68Infertility (HP:0000789)1.99877985
69Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96913584
70Bony spicule pigmentary retinopathy (HP:0007737)1.96782706
71Sclerocornea (HP:0000647)1.94381593
72Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90791870
73Thyroid-stimulating hormone excess (HP:0002925)1.90647978
74Partial duplication of thumb phalanx (HP:0009944)1.90400595
75Dyschromatopsia (HP:0007641)1.90126249
76Metabolic alkalosis (HP:0200114)1.88322977
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88182204
78Hyperphosphaturia (HP:0003109)1.87132121
79Abnormality of urine glucose concentration (HP:0011016)1.85790822
80Glycosuria (HP:0003076)1.85790822
81Partial duplication of the phalanx of hand (HP:0009999)1.83235280
82Myokymia (HP:0002411)1.80082410
83Polyphagia (HP:0002591)1.79126734
84Oligomenorrhea (HP:0000876)1.78804726
85Lissencephaly (HP:0001339)1.77062964
86Abnormal urine phosphate concentration (HP:0012599)1.76095682
87Thyroiditis (HP:0100646)1.75212739
88Medial flaring of the eyebrow (HP:0010747)1.74526428
89Hyperglycinuria (HP:0003108)1.74486270
90Hyperglycinemia (HP:0002154)1.74480918
91Decreased muscle mass (HP:0003199)1.74301420
92Abnormality of the nasal septum (HP:0000419)1.73566450
93Abnormal drinking behavior (HP:0030082)1.72655335
94Polydipsia (HP:0001959)1.72655335
95Depressed nasal ridge (HP:0000457)1.72478713
96Polyuria (HP:0000103)1.72416213
97Increased IgM level (HP:0003496)1.72385309
98Tachypnea (HP:0002789)1.70906732
99Growth hormone deficiency (HP:0000824)1.70441805
100Optic nerve coloboma (HP:0000588)1.70244517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.51844496
2STK164.01582870
3ADRBK23.16529390
4ZAK2.85626996
5FRK2.84783881
6TIE12.66247211
7WNK42.63366894
8MAP4K22.36112102
9DYRK22.21249174
10GRK12.14298399
11PIK3CA2.04307745
12NUAK12.02893342
13KIT2.01907591
14PASK1.79210580
15BCKDK1.68272737
16WNK31.63922783
17BMPR1B1.63244396
18TLK11.60502304
19TAOK31.60286118
20CAMKK21.53996221
21PRKD31.51150361
22PINK11.49943946
23TXK1.46416516
24EPHA41.30159626
25CAMKK11.23592788
26NEK21.21913717
27TEC1.21670308
28ADRBK11.11895764
29PRKCG1.09293451
30MAP2K71.08735583
31STK391.01357881
32FES1.01192006
33PRKCQ0.97723514
34STK110.97450031
35ITK0.91548843
36MARK10.89859080
37MAPK130.89119416
38NME20.88572733
39MAP3K110.86843829
40VRK10.86482583
41PHKG10.84526238
42PHKG20.84526238
43CAMK1D0.84229230
44TESK20.84007792
45WNK10.83055352
46CAMK10.82084872
47MAP3K40.82020792
48PRKCH0.81555781
49CDK80.81208013
50TGFBR10.80235031
51RPS6KA60.76926413
52RPS6KA50.76164733
53INSRR0.73285063
54LIMK10.69311875
55NME10.68337599
56MATK0.68190780
57OXSR10.68070845
58TYRO30.67777977
59NEK10.66939595
60CSNK1G30.63634056
61BTK0.63318908
62GRK50.63038784
63GRK70.62512129
64IKBKB0.62498116
65JAK30.61906715
66VRK20.58814705
67FLT30.58759219
68CHUK0.58200527
69ABL20.57224672
70NTRK20.57004620
71PAK30.55913066
72SIK20.55262300
73HIPK20.54722603
74CSNK1G20.54605592
75RPS6KA10.54553659
76RPS6KB10.54281935
77MARK30.53632288
78RPS6KC10.53333935
79RPS6KL10.53333935
80CSNK1A1L0.53235652
81PRKACA0.53155122
82CSNK2A20.52090416
83MAPKAPK50.51755059
84LRRK20.51494092
85MAPK150.50867197
86OBSCN0.49108699
87MAP3K70.48913712
88PRKCA0.48249804
89PRKCZ0.48134935
90CHEK20.46617743
91CSNK1G10.45774109
92PLK20.44625203
93DYRK30.43806167
94EPHB20.42720595
95LCK0.40601853
96CAMK2A0.40418379
97PIM10.39673478
98NTRK30.39605133
99PRKCE0.39574512
100CAMK40.38148034

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.28421036
2Oxidative phosphorylation_Homo sapiens_hsa001903.76092163
3Parkinsons disease_Homo sapiens_hsa050122.97252945
4Cardiac muscle contraction_Homo sapiens_hsa042602.85333638
5Linoleic acid metabolism_Homo sapiens_hsa005912.30886076
6Primary immunodeficiency_Homo sapiens_hsa053402.30819528
7Alzheimers disease_Homo sapiens_hsa050102.00109095
8Basal transcription factors_Homo sapiens_hsa030221.98035275
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95566581
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.85135607
11Huntingtons disease_Homo sapiens_hsa050161.82137312
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80204312
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78973231
14Nitrogen metabolism_Homo sapiens_hsa009101.74155195
15Nicotine addiction_Homo sapiens_hsa050331.63289175
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62137013
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60225747
18Asthma_Homo sapiens_hsa053101.53667164
19Arachidonic acid metabolism_Homo sapiens_hsa005901.48380354
20Protein export_Homo sapiens_hsa030601.46268140
21Sulfur relay system_Homo sapiens_hsa041221.46019747
22Phototransduction_Homo sapiens_hsa047441.45435290
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41300974
24Caffeine metabolism_Homo sapiens_hsa002321.34488785
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.33605588
26Olfactory transduction_Homo sapiens_hsa047401.24681914
27Morphine addiction_Homo sapiens_hsa050321.23489379
28Peroxisome_Homo sapiens_hsa041461.23271446
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.21848164
30RNA degradation_Homo sapiens_hsa030181.21544638
31Retinol metabolism_Homo sapiens_hsa008301.20372749
32Proteasome_Homo sapiens_hsa030501.19490515
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18677320
34Collecting duct acid secretion_Homo sapiens_hsa049661.17178787
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15621256
36Taste transduction_Homo sapiens_hsa047421.14989498
37RNA polymerase_Homo sapiens_hsa030201.13047317
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11929992
39Allograft rejection_Homo sapiens_hsa053301.11919941
40Autoimmune thyroid disease_Homo sapiens_hsa053201.09672637
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05771080
42Chemical carcinogenesis_Homo sapiens_hsa052041.04938616
43Glutamatergic synapse_Homo sapiens_hsa047241.00730341
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.00564152
45Ether lipid metabolism_Homo sapiens_hsa005650.98063750
46Fat digestion and absorption_Homo sapiens_hsa049750.97341269
47Butanoate metabolism_Homo sapiens_hsa006500.95388209
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.93301444
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91757449
50Nucleotide excision repair_Homo sapiens_hsa034200.90720314
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86535645
52Fanconi anemia pathway_Homo sapiens_hsa034600.85641118
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82163690
54Graft-versus-host disease_Homo sapiens_hsa053320.80349713
55Serotonergic synapse_Homo sapiens_hsa047260.79540863
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77661355
57Propanoate metabolism_Homo sapiens_hsa006400.77010090
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74880542
59GABAergic synapse_Homo sapiens_hsa047270.71912581
60Notch signaling pathway_Homo sapiens_hsa043300.70126067
61Circadian entrainment_Homo sapiens_hsa047130.68050886
62Hedgehog signaling pathway_Homo sapiens_hsa043400.67737027
63Type I diabetes mellitus_Homo sapiens_hsa049400.66474005
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64702391
65Rheumatoid arthritis_Homo sapiens_hsa053230.64701961
66Ovarian steroidogenesis_Homo sapiens_hsa049130.64225295
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63766674
68Pyrimidine metabolism_Homo sapiens_hsa002400.61790093
69One carbon pool by folate_Homo sapiens_hsa006700.60273215
70Metabolic pathways_Homo sapiens_hsa011000.60102813
71Tryptophan metabolism_Homo sapiens_hsa003800.59887543
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56756473
73Insulin secretion_Homo sapiens_hsa049110.55538503
74Basal cell carcinoma_Homo sapiens_hsa052170.54069059
75Fatty acid degradation_Homo sapiens_hsa000710.54065930
76Hematopoietic cell lineage_Homo sapiens_hsa046400.53371595
77Purine metabolism_Homo sapiens_hsa002300.53138266
78beta-Alanine metabolism_Homo sapiens_hsa004100.51263816
79Cholinergic synapse_Homo sapiens_hsa047250.50213798
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47495262
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46874696
82Oxytocin signaling pathway_Homo sapiens_hsa049210.45737171
83Regulation of autophagy_Homo sapiens_hsa041400.43856382
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43784741
85Glutathione metabolism_Homo sapiens_hsa004800.41903710
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40777298
87Fatty acid biosynthesis_Homo sapiens_hsa000610.40093659
88Salivary secretion_Homo sapiens_hsa049700.38251818
89Homologous recombination_Homo sapiens_hsa034400.38070789
90Antigen processing and presentation_Homo sapiens_hsa046120.37177364
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34270167
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.33461989
93Calcium signaling pathway_Homo sapiens_hsa040200.33170207
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32471228
95Synaptic vesicle cycle_Homo sapiens_hsa047210.32052363
96Renin secretion_Homo sapiens_hsa049240.31903758
97RNA transport_Homo sapiens_hsa030130.29766041
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28763566
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.28148220
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.28057826

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