RPL12P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.30849388
2viral transcription (GO:0019083)7.82353237
3translational termination (GO:0006415)7.48162231
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.59938638
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.56982628
6cotranslational protein targeting to membrane (GO:0006613)6.47076679
7protein targeting to ER (GO:0045047)6.43685414
8translational elongation (GO:0006414)6.42360716
9energy coupled proton transport, down electrochemical gradient (GO:0015985)6.38356345
10ATP synthesis coupled proton transport (GO:0015986)6.38356345
11establishment of protein localization to endoplasmic reticulum (GO:0072599)6.15921230
12protein localization to endoplasmic reticulum (GO:0070972)6.02248742
13cellular protein complex disassembly (GO:0043624)5.66704329
14viral life cycle (GO:0019058)5.60890782
15maturation of SSU-rRNA (GO:0030490)5.49930808
16ribosomal small subunit biogenesis (GO:0042274)5.46977311
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.43014973
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.09069471
19translational initiation (GO:0006413)5.07359412
20ribosomal large subunit biogenesis (GO:0042273)5.02453549
21respiratory electron transport chain (GO:0022904)4.83378149
22electron transport chain (GO:0022900)4.77828604
23protein complex disassembly (GO:0043241)4.73219381
24DNA deamination (GO:0045006)4.60576205
25macromolecular complex disassembly (GO:0032984)4.50241394
26translation (GO:0006412)4.32514780
27protein targeting to membrane (GO:0006612)4.17573305
28protein neddylation (GO:0045116)4.10680303
29protein complex biogenesis (GO:0070271)4.10108283
30nuclear-transcribed mRNA catabolic process (GO:0000956)3.90149688
31water-soluble vitamin biosynthetic process (GO:0042364)3.89824897
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.85127289
33mitochondrial respiratory chain complex assembly (GO:0033108)3.73415474
34mRNA catabolic process (GO:0006402)3.70920760
35cytidine catabolic process (GO:0006216)3.53095059
36cytidine deamination (GO:0009972)3.53095059
37cytidine metabolic process (GO:0046087)3.53095059
38ATP biosynthetic process (GO:0006754)3.47401294
39platelet dense granule organization (GO:0060155)3.45951989
40RNA catabolic process (GO:0006401)3.43733634
41hydrogen ion transmembrane transport (GO:1902600)3.42874393
42purine nucleoside triphosphate biosynthetic process (GO:0009145)3.41489523
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40079253
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.40079253
45NADH dehydrogenase complex assembly (GO:0010257)3.40079253
46purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.36781764
47cellular component biogenesis (GO:0044085)3.34155202
48ribonucleoprotein complex biogenesis (GO:0022613)3.31837271
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.31338269
50sequestering of actin monomers (GO:0042989)3.29533305
51pyrimidine ribonucleoside catabolic process (GO:0046133)3.23501539
52proton transport (GO:0015992)3.21420764
53behavioral response to nicotine (GO:0035095)3.19968505
54hydrogen transport (GO:0006818)3.14491415
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06421565
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06421565
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04458511
58GTP biosynthetic process (GO:0006183)3.03153253
59regulation of mitochondrial translation (GO:0070129)3.02856884
60chaperone-mediated protein transport (GO:0072321)3.01940103
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91020666
62proteasome assembly (GO:0043248)2.90662712
63cytochrome complex assembly (GO:0017004)2.87971307
64termination of RNA polymerase III transcription (GO:0006386)2.85953101
65transcription elongation from RNA polymerase III promoter (GO:0006385)2.85953101
66rRNA processing (GO:0006364)2.85119677
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83938171
68rRNA metabolic process (GO:0016072)2.82802643
69ribonucleoside triphosphate biosynthetic process (GO:0009201)2.82187842
70sulfation (GO:0051923)2.81953927
71establishment of protein localization to membrane (GO:0090150)2.77361884
72rRNA modification (GO:0000154)2.76690030
73protein targeting (GO:0006605)2.64227663
74regulation of cellular amino acid metabolic process (GO:0006521)2.58644133
75establishment of protein localization to organelle (GO:0072594)2.56625790
76mannosylation (GO:0097502)2.55472842
77response to interferon-beta (GO:0035456)2.55423986
78spliceosomal complex assembly (GO:0000245)2.52248843
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52191327
80negative regulation of ligase activity (GO:0051352)2.50745377
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.50745377
82UTP biosynthetic process (GO:0006228)2.50712861
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.50685841
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.49842317
85negative regulation of T cell differentiation in thymus (GO:0033085)2.49488890
86nucleoside triphosphate biosynthetic process (GO:0009142)2.47251891
87positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.46292661
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.45985498
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.45985498
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.45985498
91respiratory chain complex IV assembly (GO:0008535)2.45294943
92UTP metabolic process (GO:0046051)2.43854956
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.42095642
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42095642
95pseudouridine synthesis (GO:0001522)2.41689636
96oxidative phosphorylation (GO:0006119)2.40400831
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.40246422
98regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.37955253
99indolalkylamine catabolic process (GO:0046218)2.36777722
100tryptophan catabolic process (GO:0006569)2.36777722

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.21869591
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.04060837
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.82022696
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62990800
5EZH2_22144423_ChIP-Seq_EOC_Human3.22617777
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.19312358
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71780423
8VDR_22108803_ChIP-Seq_LS180_Human2.68539179
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63679609
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63505340
11ZNF274_21170338_ChIP-Seq_K562_Hela2.62783463
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.58752065
13VDR_23849224_ChIP-Seq_CD4+_Human2.46370933
14ELK1_19687146_ChIP-ChIP_HELA_Human2.39807073
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34010036
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20492980
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19368901
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.13731401
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11898147
20FOXP3_21729870_ChIP-Seq_TREG_Human2.04975878
21MYC_18940864_ChIP-ChIP_HL60_Human2.01925488
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97748267
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90458256
24IGF1R_20145208_ChIP-Seq_DFB_Human1.83354573
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79494537
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.74125286
27EWS_26573619_Chip-Seq_HEK293_Human1.70977831
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.68126604
29FUS_26573619_Chip-Seq_HEK293_Human1.66402371
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63122256
31TTF2_22483619_ChIP-Seq_HELA_Human1.57445333
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.54982111
33TP53_22573176_ChIP-Seq_HFKS_Human1.53639811
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49872440
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48856643
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48229917
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46970250
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46181922
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42701497
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39552429
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.36754201
42AR_20517297_ChIP-Seq_VCAP_Human1.35138965
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34563569
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34185975
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.34185975
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34177831
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29184587
48P300_19829295_ChIP-Seq_ESCs_Human1.29043827
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26622590
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25530936
51NCOR_22424771_ChIP-Seq_293T_Human1.23679209
52PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.21910605
53SOX2_19829295_ChIP-Seq_ESCs_Human1.17039025
54NANOG_19829295_ChIP-Seq_ESCs_Human1.17039025
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15770452
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.13389970
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.13286087
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12748986
59ER_23166858_ChIP-Seq_MCF-7_Human1.11341773
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.11317711
61TAF2_19829295_ChIP-Seq_ESCs_Human1.10381704
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.09678748
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08842753
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08704561
65ERG_20517297_ChIP-Seq_VCAP_Human1.08288460
66NANOG_20526341_ChIP-Seq_ESCs_Human1.07998023
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.07304004
68XRN2_22483619_ChIP-Seq_HELA_Human1.06212763
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06199914
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06176036
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06087378
72GATA3_26560356_Chip-Seq_TH2_Human1.05125380
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04495541
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04167577
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03432086
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02973378
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00848278
78ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97692412
79IRF1_19129219_ChIP-ChIP_H3396_Human0.96922844
80SOX2_16153702_ChIP-ChIP_HESCs_Human0.96194371
81BCAT_22108803_ChIP-Seq_LS180_Human0.95428998
82MYC_19829295_ChIP-Seq_ESCs_Human0.95350925
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95139372
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95133198
85HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93303042
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92796914
87HTT_18923047_ChIP-ChIP_STHdh_Human0.92309730
88ERA_21632823_ChIP-Seq_H3396_Human0.91563768
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90112853
90RNF2_27304074_Chip-Seq_NSC_Mouse0.89485979
91RBPJ_21746931_ChIP-Seq_IB4_Human0.88355135
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88227331
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87499977
94PHF8_20622853_ChIP-Seq_HELA_Human0.87458209
95CBP_20019798_ChIP-Seq_JUKART_Human0.87434025
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87434025
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86224239
98E2F4_17652178_ChIP-ChIP_JURKAT_Human0.85487137
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.84285989
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84225468

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.80181842
2MP0006292_abnormal_olfactory_placode4.44412646
3MP0005671_abnormal_response_to2.79707897
4MP0006072_abnormal_retinal_apoptosis2.42535171
5MP0004885_abnormal_endolymph2.25323595
6MP0003136_yellow_coat_color2.24300284
7MP0002837_dystrophic_cardiac_calcinosis2.23829323
8MP0005645_abnormal_hypothalamus_physiol2.10198235
9MP0005551_abnormal_eye_electrophysiolog2.08417331
10MP0005646_abnormal_pituitary_gland2.02141873
11MP0004147_increased_porphyrin_level1.99005246
12MP0005075_abnormal_melanosome_morpholog1.93674604
13MP0003011_delayed_dark_adaptation1.84177610
14MP0002102_abnormal_ear_morphology1.75161133
15MP0002095_abnormal_skin_pigmentation1.73650362
16MP0008789_abnormal_olfactory_epithelium1.73158670
17MP0008877_abnormal_DNA_methylation1.72267630
18MP0002277_abnormal_respiratory_mucosa1.71541753
19MP0002653_abnormal_ependyma_morphology1.70349877
20MP0008872_abnormal_physiological_respon1.67790936
21MP0002938_white_spotting1.66725833
22MP0001968_abnormal_touch/_nociception1.64185028
23MP0001835_abnormal_antigen_presentation1.60254242
24MP0002638_abnormal_pupillary_reflex1.57466373
25MP0005174_abnormal_tail_pigmentation1.57213338
26MP0008995_early_reproductive_senescence1.56014353
27MP0001905_abnormal_dopamine_level1.51669317
28MP0002163_abnormal_gland_morphology1.49051248
29MP0001293_anophthalmia1.46786761
30MP0005377_hearing/vestibular/ear_phenot1.44038329
31MP0003878_abnormal_ear_physiology1.44038329
32MP0002736_abnormal_nociception_after1.43950297
33MP0001485_abnormal_pinna_reflex1.42559684
34MP0004142_abnormal_muscle_tone1.37414828
35MP0005253_abnormal_eye_physiology1.35534686
36MP0003880_abnormal_central_pattern1.32429244
37MP0005084_abnormal_gallbladder_morpholo1.31109728
38MP0000631_abnormal_neuroendocrine_gland1.30527120
39MP0005360_urolithiasis1.26230240
40MP0009785_altered_susceptibility_to1.24834456
41MP0002160_abnormal_reproductive_system1.23904980
42MP0001986_abnormal_taste_sensitivity1.22276453
43MP0005379_endocrine/exocrine_gland_phen1.22021845
44MP0003786_premature_aging1.21458350
45MP0004742_abnormal_vestibular_system1.19095049
46MP0002166_altered_tumor_susceptibility1.18912322
47MP0005389_reproductive_system_phenotype1.17681558
48MP0001529_abnormal_vocalization1.17545961
49MP0003763_abnormal_thymus_physiology1.16086011
50MP0008875_abnormal_xenobiotic_pharmacok1.15867222
51MP0000372_irregular_coat_pigmentation1.15584360
52MP0001800_abnormal_humoral_immune1.13062032
53MP0005499_abnormal_olfactory_system1.10919478
54MP0005394_taste/olfaction_phenotype1.10919478
55MP0002234_abnormal_pharynx_morphology1.09724393
56MP0000049_abnormal_middle_ear1.09294811
57MP0002148_abnormal_hypersensitivity_rea1.09168718
58MP0003718_maternal_effect1.08378676
59MP0006276_abnormal_autonomic_nervous1.04633153
60MP0009333_abnormal_splenocyte_physiolog1.04494796
61MP0002006_tumorigenesis1.03481560
62MP0003806_abnormal_nucleotide_metabolis1.03143870
63MP0003646_muscle_fatigue1.01344391
64MP0003283_abnormal_digestive_organ0.99889925
65MP0002272_abnormal_nervous_system0.99800171
66MP0003195_calcinosis0.99664670
67MP0002138_abnormal_hepatobiliary_system0.97798082
68MP0001919_abnormal_reproductive_system0.94720701
69MP0009745_abnormal_behavioral_response0.92670145
70MP0002876_abnormal_thyroid_physiology0.92621728
71MP0002723_abnormal_immune_serum0.90705422
72MP0004145_abnormal_muscle_electrophysio0.89882188
73MP0005195_abnormal_posterior_eye0.87331339
74MP0006036_abnormal_mitochondrial_physio0.85920572
75MP0000026_abnormal_inner_ear0.85305012
76MP0002420_abnormal_adaptive_immunity0.84396915
77MP0003938_abnormal_ear_development0.83891685
78MP0001764_abnormal_homeostasis0.83640967
79MP0001984_abnormal_olfaction0.82337670
80MP0001819_abnormal_immune_cell0.82303669
81MP0003186_abnormal_redox_activity0.80826171
82MP0003866_abnormal_defecation0.79416374
83MP0005000_abnormal_immune_tolerance0.78995957
84MP0001873_stomach_inflammation0.77967389
85MP0002557_abnormal_social/conspecific_i0.77451930
86MP0008058_abnormal_DNA_repair0.77430327
87MP0002210_abnormal_sex_determination0.77131086
88MP0005410_abnormal_fertilization0.76766153
89MP0001970_abnormal_pain_threshold0.76343802
90MP0004133_heterotaxia0.74772945
91MP0003567_abnormal_fetal_cardiomyocyte0.73921447
92MP0002733_abnormal_thermal_nociception0.72848173
93MP0005636_abnormal_mineral_homeostasis0.72579601
94MP0001963_abnormal_hearing_physiology0.71926904
95MP0004381_abnormal_hair_follicle0.70982036
96MP0005332_abnormal_amino_acid0.70785095
97MP0002822_catalepsy0.70630055
98MP0002693_abnormal_pancreas_physiology0.69898344
99MP0005025_abnormal_response_to0.68418172
100MP0001486_abnormal_startle_reflex0.67284965

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.87101846
2Abnormality of cells of the erythroid lineage (HP:0012130)4.55455234
3Abnormal mitochondria in muscle tissue (HP:0008316)4.41519856
4Mitochondrial inheritance (HP:0001427)4.36214165
5Abnormal number of erythroid precursors (HP:0012131)4.27764532
6Reticulocytopenia (HP:0001896)4.21979952
7Acute encephalopathy (HP:0006846)4.15484501
8Progressive macrocephaly (HP:0004481)4.06528546
9Hepatocellular necrosis (HP:0001404)3.75566997
10Increased hepatocellular lipid droplets (HP:0006565)3.71372573
11Increased CSF lactate (HP:0002490)3.70370473
12Aplastic anemia (HP:0001915)3.59505539
13Macrocytic anemia (HP:0001972)3.58614283
14Lipid accumulation in hepatocytes (HP:0006561)3.55428526
15Renal Fanconi syndrome (HP:0001994)3.52294631
16Congenital stationary night blindness (HP:0007642)3.50628816
173-Methylglutaconic aciduria (HP:0003535)3.49623962
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.45761656
19Pancreatic cysts (HP:0001737)3.45488994
20Hepatic necrosis (HP:0002605)3.42376063
21Cerebral edema (HP:0002181)3.29612001
22Pancreatic fibrosis (HP:0100732)3.19163071
23Abnormal rod and cone electroretinograms (HP:0008323)3.10647671
24Increased intramyocellular lipid droplets (HP:0012240)3.09324765
25Septo-optic dysplasia (HP:0100842)3.01903768
26True hermaphroditism (HP:0010459)2.97986475
27Congenital, generalized hypertrichosis (HP:0004540)2.86079204
28Optic disc pallor (HP:0000543)2.81809800
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.80619956
30Absent/shortened dynein arms (HP:0200106)2.80619956
31IgG deficiency (HP:0004315)2.77652319
32Molar tooth sign on MRI (HP:0002419)2.72540665
33Abnormality of midbrain morphology (HP:0002418)2.72540665
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69814144
35Increased muscle lipid content (HP:0009058)2.60961623
36Abnormality of the renal cortex (HP:0011035)2.60268822
37Pallor (HP:0000980)2.58943283
38Renal cortical cysts (HP:0000803)2.49705761
39Increased IgM level (HP:0003496)2.49110449
40Pendular nystagmus (HP:0012043)2.44450409
41Abnormality of renal resorption (HP:0011038)2.39419592
42Colon cancer (HP:0003003)2.38551472
43Methylmalonic acidemia (HP:0002912)2.37028765
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.35663621
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.35663621
46Generalized aminoaciduria (HP:0002909)2.35134949
47Lactic acidosis (HP:0003128)2.34649928
48Type I transferrin isoform profile (HP:0003642)2.34168944
49Exertional dyspnea (HP:0002875)2.33144358
50Nephronophthisis (HP:0000090)2.28226332
51Medial flaring of the eyebrow (HP:0010747)2.27989547
52Lethargy (HP:0001254)2.25900779
53Abnormal ciliary motility (HP:0012262)2.25363346
54Increased serum lactate (HP:0002151)2.24351850
55Pancytopenia (HP:0001876)2.23772492
56Abolished electroretinogram (ERG) (HP:0000550)2.22409828
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22332983
58Attenuation of retinal blood vessels (HP:0007843)2.21022395
59Absent thumb (HP:0009777)2.19846077
60Decreased central vision (HP:0007663)2.19479709
61Hyperglycinemia (HP:0002154)2.18841945
62Abnormal respiratory motile cilium morphology (HP:0005938)2.14193532
63Abnormal respiratory epithelium morphology (HP:0012253)2.14193532
64Stenosis of the external auditory canal (HP:0000402)2.12525118
65Respiratory failure (HP:0002878)2.12189485
66Leukodystrophy (HP:0002415)2.11798905
67Glycosuria (HP:0003076)2.10191169
68Abnormality of urine glucose concentration (HP:0011016)2.10191169
69Sclerocornea (HP:0000647)2.09935028
70Abnormal respiratory motile cilium physiology (HP:0012261)2.08210663
71Abnormality of the renal medulla (HP:0100957)2.05332524
72Elevated erythrocyte sedimentation rate (HP:0003565)2.04870079
73Abnormality of T cell number (HP:0011839)2.02650192
74T lymphocytopenia (HP:0005403)2.01394157
75Methylmalonic aciduria (HP:0012120)1.96706342
76Respiratory difficulties (HP:0002880)1.95593335
77Polydipsia (HP:0001959)1.94341463
78Abnormal drinking behavior (HP:0030082)1.94341463
79Oral leukoplakia (HP:0002745)1.93344620
80Exercise intolerance (HP:0003546)1.90396977
81Abnormality of the prostate (HP:0008775)1.90106360
82Cystic liver disease (HP:0006706)1.86920709
83Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86413959
84Absent septum pellucidum (HP:0001331)1.86396994
85Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86374807
86Dicarboxylic aciduria (HP:0003215)1.86241897
87Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86241897
88Reduced antithrombin III activity (HP:0001976)1.85294208
89Optic nerve hypoplasia (HP:0000609)1.83509005
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82421105
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.81831226
92Stomatitis (HP:0010280)1.81639496
93Hyperphosphaturia (HP:0003109)1.80463148
94Polyuria (HP:0000103)1.76563099
95Hyperglycinuria (HP:0003108)1.75017006
96Aplasia/hypoplasia of the uterus (HP:0008684)1.74049749
97Asplenia (HP:0001746)1.70694921
98Depressed nasal ridge (HP:0000457)1.70516995
99Ketosis (HP:0001946)1.70366641
100Abnormal glycosylation (HP:0012345)1.69944051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.20448622
2TXK3.64345863
3ZAK3.10490270
4STK163.08593823
5TLK12.94812363
6PASK2.65858687
7BCKDK2.51347822
8MAP4K22.50765934
9VRK12.46004310
10KDR2.43912071
11ADRBK22.34801724
12NME12.28215455
13GRK12.25537080
14NUAK12.05697742
15WNK41.99398956
16BUB11.78847884
17MAP4K11.72003719
18BMPR1B1.61392841
19CDK191.61172536
20PINK11.59766569
21WNK31.59152447
22FRK1.49869041
23TNIK1.45357909
24DYRK21.44060580
25TAF11.37382420
26ITK1.33939959
27TIE11.27137959
28TAOK31.20841065
29TEC1.19402967
30NME21.14568086
31CDC71.14427396
32TESK21.14370109
33GRK61.08100988
34SYK1.04929247
35KIT1.01654461
36MAP3K120.98099347
37OXSR10.97197052
38PRKCQ0.94308812
39NLK0.92270038
40INSRR0.91155623
41ADRBK10.89055170
42DAPK20.88947884
43IKBKB0.87997674
44MST40.87918137
45RPS6KA50.87398199
46MUSK0.86501227
47TGFBR10.86372152
48STK390.84822220
49FES0.84629661
50MAP2K60.82004497
51NEK20.78381748
52MATK0.72219869
53PBK0.72217512
54BTK0.67464486
55CDK80.67321088
56CAMKK20.66078395
57NTRK20.64537776
58MAPKAPK50.63132447
59GRK70.61692570
60DAPK30.61632647
61FLT30.60917291
62MAPK150.60262081
63PLK30.60037362
64LCK0.59930043
65MKNK10.58702590
66CSNK2A20.58241595
67PRKCG0.56813286
68CHEK20.56203585
69LYN0.55678407
70PIM10.55629667
71EPHA40.55420296
72IKBKE0.54045695
73LIMK10.53818201
74DAPK10.53263471
75OBSCN0.51656598
76CSNK2A10.51523284
77AURKB0.50339885
78MAPK130.49654340
79CAMK10.49410564
80CSF1R0.47575579
81LRRK20.46457230
82PNCK0.45991886
83MYLK0.45295217
84PRKCE0.43525937
85PHKG10.42751454
86PHKG20.42751454
87PRKACA0.42735178
88ATR0.42263694
89MAPKAPK30.41004853
90PRKCA0.39185795
91PIK3CG0.39009348
92IGF1R0.37528988
93PLK10.36948432
94GRK50.36143503
95ILK0.34986122
96CASK0.33528985
97PLK40.30639315
98IRAK40.28608944
99CAMKK10.27942833
100BRSK20.27742858

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.95302378
2Oxidative phosphorylation_Homo sapiens_hsa001904.45478778
3Parkinsons disease_Homo sapiens_hsa050123.70923758
4Proteasome_Homo sapiens_hsa030503.39071097
5Alzheimers disease_Homo sapiens_hsa050102.48611395
6Huntingtons disease_Homo sapiens_hsa050162.38481502
7RNA polymerase_Homo sapiens_hsa030202.33510068
8Cardiac muscle contraction_Homo sapiens_hsa042602.25536198
9Primary immunodeficiency_Homo sapiens_hsa053402.25527378
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.18703596
11Homologous recombination_Homo sapiens_hsa034402.17877280
12Asthma_Homo sapiens_hsa053102.09431266
13Protein export_Homo sapiens_hsa030601.97881074
14Allograft rejection_Homo sapiens_hsa053301.94682429
15Autoimmune thyroid disease_Homo sapiens_hsa053201.94474190
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79261662
17Type I diabetes mellitus_Homo sapiens_hsa049401.68340178
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.66005358
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65878648
20Phototransduction_Homo sapiens_hsa047441.62328546
21Graft-versus-host disease_Homo sapiens_hsa053321.59162619
22Linoleic acid metabolism_Homo sapiens_hsa005911.54725348
23Mismatch repair_Homo sapiens_hsa034301.53106415
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39141830
25RNA degradation_Homo sapiens_hsa030181.35208759
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34320670
27Nitrogen metabolism_Homo sapiens_hsa009101.30410184
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27008518
29Antigen processing and presentation_Homo sapiens_hsa046121.25684902
30Basal transcription factors_Homo sapiens_hsa030221.16558428
31Nucleotide excision repair_Homo sapiens_hsa034201.16036431
32DNA replication_Homo sapiens_hsa030301.14493353
33Pyrimidine metabolism_Homo sapiens_hsa002401.10219599
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09837754
35Fanconi anemia pathway_Homo sapiens_hsa034601.07049808
36Purine metabolism_Homo sapiens_hsa002301.06455885
37Propanoate metabolism_Homo sapiens_hsa006401.06362867
38Hematopoietic cell lineage_Homo sapiens_hsa046401.05280677
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.01148514
40Spliceosome_Homo sapiens_hsa030400.98132188
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97550632
42Peroxisome_Homo sapiens_hsa041460.93148282
43Chemical carcinogenesis_Homo sapiens_hsa052040.89869586
44Retinol metabolism_Homo sapiens_hsa008300.89009747
45One carbon pool by folate_Homo sapiens_hsa006700.87887097
46Rheumatoid arthritis_Homo sapiens_hsa053230.84801851
47Caffeine metabolism_Homo sapiens_hsa002320.84768012
48RNA transport_Homo sapiens_hsa030130.82962638
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82859316
50Base excision repair_Homo sapiens_hsa034100.79785421
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78805369
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76656812
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76493793
54Arachidonic acid metabolism_Homo sapiens_hsa005900.75452663
55Nicotine addiction_Homo sapiens_hsa050330.72260732
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71466002
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71186344
58Tryptophan metabolism_Homo sapiens_hsa003800.68849977
59Systemic lupus erythematosus_Homo sapiens_hsa053220.67789036
60Olfactory transduction_Homo sapiens_hsa047400.65483457
61Butanoate metabolism_Homo sapiens_hsa006500.65103191
62Metabolic pathways_Homo sapiens_hsa011000.63166470
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57389035
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56962534
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56318314
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56105539
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.54664397
68Selenocompound metabolism_Homo sapiens_hsa004500.54638361
69T cell receptor signaling pathway_Homo sapiens_hsa046600.52653083
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50494208
71Ether lipid metabolism_Homo sapiens_hsa005650.49982809
72Taste transduction_Homo sapiens_hsa047420.49464090
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49334510
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46819761
75Regulation of autophagy_Homo sapiens_hsa041400.44179391
76Fat digestion and absorption_Homo sapiens_hsa049750.43493593
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40928323
78Folate biosynthesis_Homo sapiens_hsa007900.40168659
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38701182
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37894564
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36493066
82Sulfur metabolism_Homo sapiens_hsa009200.35324203
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.34867212
84Hedgehog signaling pathway_Homo sapiens_hsa043400.33420422
85Glutathione metabolism_Homo sapiens_hsa004800.31861955
86Mineral absorption_Homo sapiens_hsa049780.30685649
87Viral myocarditis_Homo sapiens_hsa054160.29833522
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28984528
89Morphine addiction_Homo sapiens_hsa050320.28435206
90Collecting duct acid secretion_Homo sapiens_hsa049660.28370447
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.27143006
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27034219
93Staphylococcus aureus infection_Homo sapiens_hsa051500.26773359
94Salivary secretion_Homo sapiens_hsa049700.25826464
95Sulfur relay system_Homo sapiens_hsa041220.25047804
96Basal cell carcinoma_Homo sapiens_hsa052170.22904577
97Fatty acid degradation_Homo sapiens_hsa000710.20729616
98Serotonergic synapse_Homo sapiens_hsa047260.20065074
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.18572105
100Insulin secretion_Homo sapiens_hsa049110.18518225

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