ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.94873600
2	viral transcription (GO:0019083)	7.80142452
3	translational termination (GO:0006415)	7.54245739
4	maturation of SSU-rRNA (GO:0030490)	6.90983865
5	ribosomal small subunit biogenesis (GO:0042274)	6.64919630
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.56023917
7	cotranslational protein targeting to membrane (GO:0006613)	6.44817797
8	protein targeting to ER (GO:0045047)	6.39901682
9	translational elongation (GO:0006414)	6.28728960
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.12688364
11	protein localization to endoplasmic reticulum (GO:0070972)	6.02251601
12	ATP synthesis coupled proton transport (GO:0015986)	5.82522438
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.82522438
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.75803228
15	cellular protein complex disassembly (GO:0043624)	5.65178597
16	viral life cycle (GO:0019058)	5.58969390
17	protein neddylation (GO:0045116)	5.52645138
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.44203191
19	ribosomal large subunit biogenesis (GO:0042273)	5.41173855
20	chaperone-mediated protein transport (GO:0072321)	5.25519518
21	translational initiation (GO:0006413)	5.21534743
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.09707046
23	respiratory electron transport chain (GO:0022904)	4.81431350
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.75580332
25	NADH dehydrogenase complex assembly (GO:0010257)	4.75580332
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.75580332
27	electron transport chain (GO:0022900)	4.75282730
28	protein complex disassembly (GO:0043241)	4.73885849
29	translation (GO:0006412)	4.61386549
30	macromolecular complex disassembly (GO:0032984)	4.55675663
31	protein complex biogenesis (GO:0070271)	4.52278700
32	protein targeting to membrane (GO:0006612)	4.36728088
33	mitochondrial respiratory chain complex assembly (GO:0033108)	4.05720884
34	behavioral response to nicotine (GO:0035095)	4.01551436
35	DNA deamination (GO:0045006)	4.00361362
36	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.94928839
37	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.92752359
38	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.87203321
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.85963958
40	ribonucleoprotein complex biogenesis (GO:0022613)	3.84037771
41	cellular component biogenesis (GO:0044085)	3.82152037
42	mRNA catabolic process (GO:0006402)	3.71448459
43	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.55214183
44	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.55214183
45	GTP biosynthetic process (GO:0006183)	3.47264809
46	water-soluble vitamin biosynthetic process (GO:0042364)	3.45918049
47	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.44787395
48	RNA catabolic process (GO:0006401)	3.43571069
49	hydrogen ion transmembrane transport (GO:1902600)	3.42678896
50	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.41743371
51	ATP biosynthetic process (GO:0006754)	3.39999759
52	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.37544817
53	termination of RNA polymerase III transcription (GO:0006386)	3.37544817
54	rRNA processing (GO:0006364)	3.25646320
55	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.23583543
56	rRNA metabolic process (GO:0016072)	3.21801396
57	kynurenine metabolic process (GO:0070189)	3.20457243
58	proton transport (GO:0015992)	3.16513104
59	hydrogen transport (GO:0006818)	3.10386084
60	proteasome assembly (GO:0043248)	3.06929346
61	respiratory chain complex IV assembly (GO:0008535)	3.04238584
62	cell proliferation in forebrain (GO:0021846)	3.02944037
63	somite development (GO:0061053)	2.98430964
64	establishment of protein localization to membrane (GO:0090150)	2.98030398
65	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.97254239
66	protein targeting (GO:0006605)	2.94124466
67	UTP biosynthetic process (GO:0006228)	2.89108082
68	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.88711862
69	inner mitochondrial membrane organization (GO:0007007)	2.82369487
70	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.78537894
71	platelet dense granule organization (GO:0060155)	2.77028333
72	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.72050153
73	aldehyde catabolic process (GO:0046185)	2.71053895
74	protein targeting to mitochondrion (GO:0006626)	2.69083579
75	UTP metabolic process (GO:0046051)	2.68643116
76	indole-containing compound catabolic process (GO:0042436)	2.65971131
77	indolalkylamine catabolic process (GO:0046218)	2.65971131
78	tryptophan catabolic process (GO:0006569)	2.65971131
79	cellular ketone body metabolic process (GO:0046950)	2.64940644
80	nucleoside triphosphate biosynthetic process (GO:0009142)	2.60951773
81	protein localization to mitochondrion (GO:0070585)	2.58913349
82	cytochrome complex assembly (GO:0017004)	2.58004554
83	establishment of protein localization to organelle (GO:0072594)	2.56595869
84	establishment of protein localization to mitochondrion (GO:0072655)	2.51632149
85	DNA demethylation (GO:0080111)	2.51022839
86	chromatin remodeling at centromere (GO:0031055)	2.50584047
87	pseudouridine synthesis (GO:0001522)	2.49498097
88	organelle disassembly (GO:1903008)	2.48263958
89	piRNA metabolic process (GO:0034587)	2.46826855
90	regulation of cellular respiration (GO:0043457)	2.44399969
91	regulation of mitotic spindle checkpoint (GO:1903504)	2.43372904
92	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.43372904
93	CTP metabolic process (GO:0046036)	2.43236422
94	CTP biosynthetic process (GO:0006241)	2.43236422
95	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.36928188
96	substrate-independent telencephalic tangential migration (GO:0021826)	2.36928188
97	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.36313433
98	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.36313433
99	nucleoside diphosphate phosphorylation (GO:0006165)	2.35500057
100	ketone body metabolic process (GO:1902224)	2.35348035

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.36806165
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.26109236
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.83571200
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.47353153
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.11864337
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.85653797
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.73132306
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.70681841
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.57994599
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.47932166
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.47241999
12	VDR_22108803_ChIP-Seq_LS180_Human	2.37863572
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.37410462
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.32282955
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.16937870
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14595887
17	IRF1_19129219_ChIP-ChIP_H3396_Human	2.10575166
18	TTF2_22483619_ChIP-Seq_HELA_Human	2.03754118
19	ZNF274_21170338_ChIP-Seq_K562_Hela	2.02037577
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95399210
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.91717518
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.86579562
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.77388621
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.73918787
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71852827
26	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.71324330
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.70087449
28	EWS_26573619_Chip-Seq_HEK293_Human	1.68769283
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.63053917
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62415712
31	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.57883753
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.57821587
33	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.57682847
34	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.53028754
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47494333
36	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.41500888
37	FUS_26573619_Chip-Seq_HEK293_Human	1.39303421
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.36155187
39	XRN2_22483619_ChIP-Seq_HELA_Human	1.34143745
40	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.33940565
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33918115
42	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.32514084
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30218285
44	TAF2_19829295_ChIP-Seq_ESCs_Human	1.29428378
45	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.29231554
46	GABP_19822575_ChIP-Seq_HepG2_Human	1.28424853
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28172439
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27770875
49	MYC_19829295_ChIP-Seq_ESCs_Human	1.24945849
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24121044
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24121044
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22713131
53	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.18403980
54	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.18315498
55	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.17299382
56	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.16958476
57	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.16349506
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15840382
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15201982
60	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.11422310
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11349905
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10974323
63	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09352113
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07358733
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07358733
66	P300_19829295_ChIP-Seq_ESCs_Human	1.05376182
67	AR_20517297_ChIP-Seq_VCAP_Human	1.04168984
68	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.03914646
69	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03209881
70	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02176970
71	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.01510626
72	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01338683
73	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99973638
74	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.99823460
75	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.99106729
76	NCOR_22424771_ChIP-Seq_293T_Human	0.97706464
77	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.96554988
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95648413
79	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.95249838
80	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.93604757
81	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.93166519
82	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.92004846
83	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.91694670
84	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.89859671
85	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.88987843
86	ERA_21632823_ChIP-Seq_H3396_Human	0.88859913
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.88515869
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.87573890
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.87159664
90	HOXB7_26014856_ChIP-Seq_BT474_Human	0.87121944
91	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.86466347
92	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.85965227
93	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.85431762
94	ER_23166858_ChIP-Seq_MCF-7_Human	0.84592879
95	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.84284115
96	TCF4_22108803_ChIP-Seq_LS180_Human	0.84142811
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.83029868
98	DCP1A_22483619_ChIP-Seq_HELA_Human	0.82916844
99	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.82578674
100	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.82225990

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.63208837
2	MP0006292_abnormal_olfactory_placode	4.33367738
3	MP0008877_abnormal_DNA_methylation	3.41026254
4	MP0004142_abnormal_muscle_tone	2.85032010
5	MP0003787_abnormal_imprinting	2.54695016
6	MP0003122_maternal_imprinting	2.32624490
7	MP0003195_calcinosis	2.32607968
8	MP0003878_abnormal_ear_physiology	2.18867489
9	MP0005377_hearing/vestibular/ear_phenot	2.18867489
10	MP0003646_muscle_fatigue	2.12499169
11	MP0002837_dystrophic_cardiac_calcinosis	2.01576469
12	MP0003806_abnormal_nucleotide_metabolis	1.98059700
13	MP0001188_hyperpigmentation	1.96288499
14	MP0004885_abnormal_endolymph	1.92767032
15	MP0001293_anophthalmia	1.76335151
16	MP0003121_genomic_imprinting	1.74591967
17	MP0008872_abnormal_physiological_respon	1.72786148
18	MP0005084_abnormal_gallbladder_morpholo	1.72056195
19	MP0001835_abnormal_antigen_presentation	1.68244068
20	MP0005551_abnormal_eye_electrophysiolog	1.66478568
21	MP0006276_abnormal_autonomic_nervous	1.65793746
22	MP0002272_abnormal_nervous_system	1.62831184
23	MP0004145_abnormal_muscle_electrophysio	1.57624710
24	MP0005671_abnormal_response_to	1.55289088
25	MP0002163_abnormal_gland_morphology	1.55227337
26	MP0006072_abnormal_retinal_apoptosis	1.50313750
27	MP0003186_abnormal_redox_activity	1.50199721
28	MP0005646_abnormal_pituitary_gland	1.48862133
29	MP0002234_abnormal_pharynx_morphology	1.42533430
30	MP0001529_abnormal_vocalization	1.41301167
31	MP0004043_abnormal_pH_regulation	1.40408645
32	MP0005645_abnormal_hypothalamus_physiol	1.40375766
33	MP0002102_abnormal_ear_morphology	1.34514757
34	MP0003283_abnormal_digestive_organ	1.34204652
35	MP0006036_abnormal_mitochondrial_physio	1.34127031
36	MP0001485_abnormal_pinna_reflex	1.32695102
37	MP0001968_abnormal_touch/_nociception	1.31091373
38	MP0008875_abnormal_xenobiotic_pharmacok	1.29452239
39	MP0001440_abnormal_grooming_behavior	1.25618657
40	MP0005389_reproductive_system_phenotype	1.25393546
41	MP0002736_abnormal_nociception_after	1.24145296
42	MP0009046_muscle_twitch	1.21677143
43	MP0003011_delayed_dark_adaptation	1.21018350
44	MP0003123_paternal_imprinting	1.19020167
45	MP0000049_abnormal_middle_ear	1.17644518
46	MP0001348_abnormal_lacrimal_gland	1.17090465
47	MP0004147_increased_porphyrin_level	1.17035692
48	MP0005075_abnormal_melanosome_morpholog	1.16723355
49	MP0002160_abnormal_reproductive_system	1.15821958
50	MP0003567_abnormal_fetal_cardiomyocyte	1.14719389
51	MP0008995_early_reproductive_senescence	1.14142718
52	MP0001486_abnormal_startle_reflex	1.11058293
53	MP0008775_abnormal_heart_ventricle	1.10254737
54	MP0002138_abnormal_hepatobiliary_system	1.09385133
55	MP0005367_renal/urinary_system_phenotyp	1.08480990
56	MP0000516_abnormal_urinary_system	1.08480990
57	MP0003880_abnormal_central_pattern	1.08133017
58	MP0001905_abnormal_dopamine_level	1.05040901
59	MP0004742_abnormal_vestibular_system	1.02562638
60	MP0002938_white_spotting	1.01344983
61	MP0009764_decreased_sensitivity_to	1.00880023
62	MP0001970_abnormal_pain_threshold	1.00255440
63	MP0005174_abnormal_tail_pigmentation	0.99879228
64	MP0001919_abnormal_reproductive_system	0.99301152
65	MP0009745_abnormal_behavioral_response	0.98680513
66	MP0002184_abnormal_innervation	0.98625877
67	MP0002557_abnormal_social/conspecific_i	0.98432613
68	MP0005423_abnormal_somatic_nervous	0.98251190
69	MP0005379_endocrine/exocrine_gland_phen	0.97487713
70	MP0000631_abnormal_neuroendocrine_gland	0.94436439
71	MP0003693_abnormal_embryo_hatching	0.91902783
72	MP0001764_abnormal_homeostasis	0.90861902
73	MP0002277_abnormal_respiratory_mucosa	0.90309936
74	MP0002210_abnormal_sex_determination	0.89044976
75	MP0002095_abnormal_skin_pigmentation	0.87852396
76	MP0003638_abnormal_response/metabolism_	0.84938082
77	MP0008058_abnormal_DNA_repair	0.84869268
78	MP0002653_abnormal_ependyma_morphology	0.81431926
79	MP0002572_abnormal_emotion/affect_behav	0.80964145
80	MP0005195_abnormal_posterior_eye	0.80594235
81	MP0003718_maternal_effect	0.80214287
82	MP0005670_abnormal_white_adipose	0.78578115
83	MP0002733_abnormal_thermal_nociception	0.78414217
84	MP0001286_abnormal_eye_development	0.75004851
85	MP0005332_abnormal_amino_acid	0.74724502
86	MP0000026_abnormal_inner_ear	0.74296042
87	MP0005253_abnormal_eye_physiology	0.73603263
88	MP0002752_abnormal_somatic_nervous	0.72769317
89	MP0001765_abnormal_ion_homeostasis	0.72220819
90	MP0001986_abnormal_taste_sensitivity	0.72216800
91	MP0001963_abnormal_hearing_physiology	0.71175726
92	MP0003119_abnormal_digestive_system	0.70486624
93	MP0001663_abnormal_digestive_system	0.69871101
94	MP0005410_abnormal_fertilization	0.68660893
95	MP0002876_abnormal_thyroid_physiology	0.67962281
96	MP0000955_abnormal_spinal_cord	0.65782387
97	MP0003938_abnormal_ear_development	0.65704725
98	MP0003252_abnormal_bile_duct	0.65640056
99	MP0000653_abnormal_sex_gland	0.65010454
100	MP0001145_abnormal_male_reproductive	0.64945731

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.59675866
2	Reticulocytopenia (HP:0001896)	5.43689829
3	Abnormal mitochondria in muscle tissue (HP:0008316)	5.00775839
4	Acute encephalopathy (HP:0006846)	4.77434185
5	Abnormality of cells of the erythroid lineage (HP:0012130)	4.70674168
6	Progressive macrocephaly (HP:0004481)	4.62797428
7	Mitochondrial inheritance (HP:0001427)	4.57654009
8	Macrocytic anemia (HP:0001972)	4.27662770
9	Hepatocellular necrosis (HP:0001404)	4.21006334
10	Increased CSF lactate (HP:0002490)	4.08372929
11	Abnormal number of erythroid precursors (HP:0012131)	4.05902369
12	Hepatic necrosis (HP:0002605)	3.80429466
13	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.42590147
14	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.42590147
15	Cerebral edema (HP:0002181)	3.41470502
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.28134076
17	Pancreatic cysts (HP:0001737)	3.14864961
18	Increased hepatocellular lipid droplets (HP:0006565)	3.03810635
19	Pallor (HP:0000980)	3.02338457
20	Pancreatic fibrosis (HP:0100732)	2.99610340
21	Lipid accumulation in hepatocytes (HP:0006561)	2.90534257
22	Congenital, generalized hypertrichosis (HP:0004540)	2.90163069
23	Optic disc pallor (HP:0000543)	2.85368518
24	Nephronophthisis (HP:0000090)	2.67075226
25	Methylmalonic acidemia (HP:0002912)	2.65693102
26	Leukodystrophy (HP:0002415)	2.60688366
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.59536585
28	Abnormality of midbrain morphology (HP:0002418)	2.54790704
29	Molar tooth sign on MRI (HP:0002419)	2.54790704
30	Renal Fanconi syndrome (HP:0001994)	2.54723310
31	True hermaphroditism (HP:0010459)	2.50843708
32	Sclerocornea (HP:0000647)	2.47077548
33	3-Methylglutaconic aciduria (HP:0003535)	2.43402782
34	Lactic acidosis (HP:0003128)	2.41329777
35	Respiratory failure (HP:0002878)	2.40889701
36	Increased serum lactate (HP:0002151)	2.39625303
37	Myokymia (HP:0002411)	2.38696812
38	Pendular nystagmus (HP:0012043)	2.38102880
39	Methylmalonic aciduria (HP:0012120)	2.29855042
40	Lethargy (HP:0001254)	2.28438618
41	Porencephaly (HP:0002132)	2.27930717
42	Exertional dyspnea (HP:0002875)	2.24730206
43	Type 2 muscle fiber atrophy (HP:0003554)	2.23619701
44	Increased intramyocellular lipid droplets (HP:0012240)	2.23328759
45	Hypomagnesemia (HP:0002917)	2.20563169
46	Absent thumb (HP:0009777)	2.15798760
47	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.14593696
48	Congenital stationary night blindness (HP:0007642)	2.12790121
49	Rib fusion (HP:0000902)	2.08416440
50	Hyperglycinemia (HP:0002154)	2.08019388
51	Septo-optic dysplasia (HP:0100842)	2.07931784
52	Type II lissencephaly (HP:0007260)	2.05118114
53	Abnormality of renal resorption (HP:0011038)	2.03089377
54	Small hand (HP:0200055)	2.02884956
55	Exercise intolerance (HP:0003546)	2.01998597
56	Stenosis of the external auditory canal (HP:0000402)	2.00995412
57	Abnormality of DNA repair (HP:0003254)	2.00829063
58	Abnormality of magnesium homeostasis (HP:0004921)	1.97806103
59	Cleft eyelid (HP:0000625)	1.97597328
60	Poor suck (HP:0002033)	1.96895561
61	CNS hypomyelination (HP:0003429)	1.96119843
62	Abolished electroretinogram (ERG) (HP:0000550)	1.94795371
63	Abnormal hemoglobin (HP:0011902)	1.93870620
64	Abnormality of the renal medulla (HP:0100957)	1.91409631
65	Abnormal number of incisors (HP:0011064)	1.88689179
66	Abnormality of urine glucose concentration (HP:0011016)	1.88422179
67	Glycosuria (HP:0003076)	1.88422179
68	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.87015163
69	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.86721339
70	Decreased central vision (HP:0007663)	1.85784607
71	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.85436074
72	Absent/shortened dynein arms (HP:0200106)	1.85436074
73	Increased muscle lipid content (HP:0009058)	1.84827497
74	Muscle fiber atrophy (HP:0100295)	1.84024042
75	Abnormality of the labia minora (HP:0012880)	1.83826920
76	Hypothermia (HP:0002045)	1.82853030
77	Anencephaly (HP:0002323)	1.81351450
78	Polyphagia (HP:0002591)	1.80258832
79	Male pseudohermaphroditism (HP:0000037)	1.79903672
80	Asplenia (HP:0001746)	1.76830749
81	X-linked dominant inheritance (HP:0001423)	1.73608354
82	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.73594054
83	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.73407390
84	IgG deficiency (HP:0004315)	1.72641857
85	Medial flaring of the eyebrow (HP:0010747)	1.72448083
86	CNS demyelination (HP:0007305)	1.71527837
87	Stomatitis (HP:0010280)	1.71420986
88	Depressed nasal ridge (HP:0000457)	1.70789231
89	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.69284997
90	Cystic liver disease (HP:0006706)	1.66542554
91	Testicular atrophy (HP:0000029)	1.65787896
92	Anophthalmia (HP:0000528)	1.63820284
93	Dicarboxylic aciduria (HP:0003215)	1.62772005
94	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.62772005
95	Increased corneal curvature (HP:0100692)	1.59288808
96	Keratoconus (HP:0000563)	1.59288808
97	Blindness (HP:0000618)	1.58964639
98	Triphalangeal thumb (HP:0001199)	1.58185517
99	Growth hormone deficiency (HP:0000824)	1.58056747
100	Median cleft lip (HP:0000161)	1.57469891

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.43023918
2	WNK4	3.00767291
3	TLK1	2.93225551
4	CDK19	2.89242381
5	GRK1	2.35570360
6	ADRBK2	2.33110946
7	DYRK2	2.30496942
8	TXK	2.19557077
9	VRK2	2.18240157
10	MAP3K12	2.09189772
11	TIE1	1.92489621
12	MAP4K2	1.84632629
13	STK39	1.68722135
14	OXSR1	1.64237812
15	FRK	1.61807741
16	NME2	1.60471498
17	WNK3	1.57676335
18	ZAK	1.52159087
19	TAOK3	1.44585269
20	BMPR1B	1.39032977
21	MYLK	1.37934937
22	MST4	1.37778548
23	ILK	1.37460679
24	PINK1	1.37202904
25	NME1	1.28218414
26	EPHB2	1.26810892
27	NUAK1	1.23719470
28	TEC	1.15783125
29	TAF1	1.13100964
30	PIK3CG	1.12361898
31	DAPK3	1.10392845
32	PHKG1	1.09347341
33	PHKG2	1.09347341
34	VRK1	1.07850582
35	NEK1	1.07282838
36	INSRR	1.04377899
37	SIK2	1.02331548
38	PRKD3	0.99520208
39	MAP4K1	0.99021381
40	RPS6KA5	0.97854719
41	PRKCG	0.93358518
42	TRIM28	0.93162137
43	ADRBK1	0.92335227
44	RPS6KA4	0.92129085
45	MAP3K11	0.91510542
46	AURKA	0.90637325
47	MAPK13	0.90331967
48	PLK4	0.89875729
49	CAMKK2	0.89358956
50	ABL2	0.89308839
51	IKBKB	0.83586766
52	CAMK1	0.82758173
53	TNIK	0.79963711
54	PRKCE	0.78094600
55	EPHA3	0.77667573
56	PASK	0.77046621
57	CSNK2A2	0.77040783
58	PLK1	0.76095298
59	OBSCN	0.72176727
60	BCKDK	0.72123764
61	MAP2K7	0.70810320
62	MKNK2	0.70444988
63	AURKB	0.69919612
64	GRK7	0.69425685
65	CDK8	0.68591931
66	SRPK1	0.68551722
67	CSNK1G2	0.68284617
68	PRKACA	0.67564773
69	BUB1	0.66660179
70	PIK3CA	0.66486152
71	WNK1	0.65257895
72	SIK3	0.64326911
73	CSNK2A1	0.60486649
74	RPS6KA6	0.60361732
75	CDC7	0.59079625
76	MATK	0.58995426
77	PLK3	0.58123016
78	MINK1	0.57562506
79	MARK3	0.56465744
80	RPS6KB2	0.55957046
81	CSNK1G3	0.53757009
82	KIT	0.52908748
83	MAPKAPK3	0.52846445
84	PAK3	0.52813926
85	PRKCD	0.52354959
86	CSNK1E	0.51927527
87	MAP2K6	0.51391210
88	CSNK1A1	0.49118288
89	GRK6	0.47897834
90	PRKCQ	0.46626243
91	PIM1	0.46480842
92	PRKCA	0.46057655
93	PRKG1	0.45785751
94	LIMK1	0.44143091
95	PRKCZ	0.43800413
96	STK38L	0.41478126
97	DAPK1	0.41445037
98	ITK	0.40262269
99	RPS6KC1	0.39666824
100	RPS6KL1	0.39666824

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.12589850
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.42785051
3	Parkinsons disease_Homo sapiens_hsa05012	3.52701167
4	Asthma_Homo sapiens_hsa05310	3.16276564
5	Proteasome_Homo sapiens_hsa03050	2.55699014
6	Alzheimers disease_Homo sapiens_hsa05010	2.51344951
7	Huntingtons disease_Homo sapiens_hsa05016	2.48247487
8	Protein export_Homo sapiens_hsa03060	2.43608545
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.39448479
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.30443068
11	RNA polymerase_Homo sapiens_hsa03020	2.28177600
12	Allograft rejection_Homo sapiens_hsa05330	2.19674327
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.18447054
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.05861351
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.98583685
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.94528401
17	Homologous recombination_Homo sapiens_hsa03440	1.82344531
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.78827711
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.68509379
20	RNA degradation_Homo sapiens_hsa03018	1.56465347
21	One carbon pool by folate_Homo sapiens_hsa00670	1.54578454
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.45955395
23	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.27214235
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.27168253
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.26953938
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.26544921
27	Rheumatoid arthritis_Homo sapiens_hsa05323	1.18066018
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.14220487
29	Basal transcription factors_Homo sapiens_hsa03022	1.13594255
30	Phototransduction_Homo sapiens_hsa04744	1.13105052
31	Mismatch repair_Homo sapiens_hsa03430	1.10676577
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.09522045
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.07366920
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.02029904
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01907101
36	Butanoate metabolism_Homo sapiens_hsa00650	0.97599790
37	Sulfur relay system_Homo sapiens_hsa04122	0.91140099
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.89561592
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.86182441
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85809558
41	Purine metabolism_Homo sapiens_hsa00230	0.84712495
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83471121
43	Regulation of autophagy_Homo sapiens_hsa04140	0.83190113
44	Spliceosome_Homo sapiens_hsa03040	0.82803659
45	DNA replication_Homo sapiens_hsa03030	0.81726491
46	Propanoate metabolism_Homo sapiens_hsa00640	0.78919358
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.77725168
48	RNA transport_Homo sapiens_hsa03013	0.76432912
49	Nicotine addiction_Homo sapiens_hsa05033	0.76097626
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.73697301
51	Folate biosynthesis_Homo sapiens_hsa00790	0.71599324
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68107656
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67529052
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.65945633
55	Olfactory transduction_Homo sapiens_hsa04740	0.63784778
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62116519
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.61925419
58	Metabolic pathways_Homo sapiens_hsa01100	0.61642924
59	Antigen processing and presentation_Homo sapiens_hsa04612	0.61327862
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.59818284
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58709843
62	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.58047798
63	Peroxisome_Homo sapiens_hsa04146	0.57444401
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55690161
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.55392942
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.52215076
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51534043
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.51476455
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.50762295
70	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50309680
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48887105
72	Retinol metabolism_Homo sapiens_hsa00830	0.47323240
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46950075
74	Primary immunodeficiency_Homo sapiens_hsa05340	0.46177983
75	Viral myocarditis_Homo sapiens_hsa05416	0.46175264
76	Glutathione metabolism_Homo sapiens_hsa00480	0.43982078
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.43127651
78	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42104592
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40184111
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39471929
81	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37529523
82	Salivary secretion_Homo sapiens_hsa04970	0.35207130
83	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.31498628
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31232865
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.30749211
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.29829940
87	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.29449939
88	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.28662792
89	Morphine addiction_Homo sapiens_hsa05032	0.27116940
90	Base excision repair_Homo sapiens_hsa03410	0.26556493
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.26497454
92	Caffeine metabolism_Homo sapiens_hsa00232	0.26479024
93	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.26108648
94	Selenocompound metabolism_Homo sapiens_hsa00450	0.25149972
95	Taste transduction_Homo sapiens_hsa04742	0.24731843
96	Insulin secretion_Homo sapiens_hsa04911	0.19987260
97	Serotonergic synapse_Homo sapiens_hsa04726	0.19132836
98	Circadian entrainment_Homo sapiens_hsa04713	0.17139809
99	Fatty acid elongation_Homo sapiens_hsa00062	0.16316869
100	Non-homologous end-joining_Homo sapiens_hsa03450	0.15954883

RPL12P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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