ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.04398421
2	positive regulation of respiratory burst (GO:0060267)	4.94694364
3	chaperone-mediated protein transport (GO:0072321)	4.93861788
4	water-soluble vitamin biosynthetic process (GO:0042364)	4.93195921
5	protein complex biogenesis (GO:0070271)	4.78114953
6	mitochondrial respiratory chain complex assembly (GO:0033108)	4.56271170
7	DNA deamination (GO:0045006)	4.53635972
8	ATP synthesis coupled proton transport (GO:0015986)	4.49882895
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.49882895
10	viral transcription (GO:0019083)	4.32221989
11	translational termination (GO:0006415)	4.21633985
12	protein neddylation (GO:0045116)	4.15585165
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.10066386
14	NADH dehydrogenase complex assembly (GO:0010257)	4.10066386
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.10066386
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.04287762
17	cytochrome complex assembly (GO:0017004)	3.99038217
18	maturation of SSU-rRNA (GO:0030490)	3.92671007
19	behavioral response to nicotine (GO:0035095)	3.88907488
20	regulation of immunoglobulin secretion (GO:0051023)	3.88779721
21	regulation of mitochondrial translation (GO:0070129)	3.80709918
22	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.78409904
23	cotranslational protein targeting to membrane (GO:0006613)	3.75109211
24	translational elongation (GO:0006414)	3.74335992
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.71527867
26	protein targeting to ER (GO:0045047)	3.70317812
27	protein localization to endoplasmic reticulum (GO:0070972)	3.63545526
28	ribosomal small subunit biogenesis (GO:0042274)	3.56821190
29	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.52540166
30	proteasome assembly (GO:0043248)	3.52004183
31	respiratory chain complex IV assembly (GO:0008535)	3.51792050
32	cellular component biogenesis (GO:0044085)	3.50079351
33	piRNA metabolic process (GO:0034587)	3.48822125
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.45491257
35	mannosylation (GO:0097502)	3.31642918
36	electron transport chain (GO:0022900)	3.28958074
37	respiratory electron transport chain (GO:0022904)	3.28800932
38	viral life cycle (GO:0019058)	3.27894189
39	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.25682563
40	cytidine metabolic process (GO:0046087)	3.25608689
41	cytidine catabolic process (GO:0006216)	3.25608689
42	cytidine deamination (GO:0009972)	3.25608689
43	translation (GO:0006412)	3.17976872
44	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.12286405
45	cellular ketone body metabolic process (GO:0046950)	3.09888839
46	ribonucleoprotein complex biogenesis (GO:0022613)	3.09233301
47	cellular protein complex disassembly (GO:0043624)	3.09215027
48	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.07598327
49	ribosomal large subunit biogenesis (GO:0042273)	3.06711535
50	keratinocyte development (GO:0003334)	3.06388792
51	intracellular protein transmembrane import (GO:0044743)	3.05128658
52	ketone body metabolic process (GO:1902224)	3.03847044
53	DNA damage response, detection of DNA damage (GO:0042769)	3.03559833
54	GTP biosynthetic process (GO:0006183)	3.01791655
55	ribosome biogenesis (GO:0042254)	2.99201915
56	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.98293395
57	translational initiation (GO:0006413)	2.97029703
58	ubiquinone biosynthetic process (GO:0006744)	2.95756222
59	response to redox state (GO:0051775)	2.93936063
60	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.91702953
61	regulation of respiratory burst (GO:0060263)	2.86660955
62	base-excision repair, AP site formation (GO:0006285)	2.85520713
63	pseudouridine synthesis (GO:0001522)	2.85116479
64	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.84119039
65	protein-cofactor linkage (GO:0018065)	2.84053379
66	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.81647866
67	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.81647866
68	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.73304036
69	positive regulation of defense response to virus by host (GO:0002230)	2.72697045
70	replication fork processing (GO:0031297)	2.71899643
71	peptidyl-histidine modification (GO:0018202)	2.70214064
72	cobalamin metabolic process (GO:0009235)	2.69278434
73	rRNA metabolic process (GO:0016072)	2.67255841
74	hydrogen ion transmembrane transport (GO:1902600)	2.67197474
75	adaptation of signaling pathway (GO:0023058)	2.66120316
76	rRNA processing (GO:0006364)	2.65569029
77	protein targeting to mitochondrion (GO:0006626)	2.65546375
78	kinetochore assembly (GO:0051382)	2.62762265
79	terpenoid biosynthetic process (GO:0016114)	2.61641048
80	quinone biosynthetic process (GO:1901663)	2.61337408
81	regulation of cellular amino acid metabolic process (GO:0006521)	2.58615646
82	protein peptidyl-prolyl isomerization (GO:0000413)	2.58600376
83	auditory receptor cell differentiation (GO:0042491)	2.58181717
84	positive regulation of prostaglandin secretion (GO:0032308)	2.54643825
85	branched-chain amino acid catabolic process (GO:0009083)	2.54504975
86	vitamin biosynthetic process (GO:0009110)	2.54053498
87	establishment of protein localization to mitochondrion (GO:0072655)	2.53418189
88	ubiquinone metabolic process (GO:0006743)	2.53413844
89	seminiferous tubule development (GO:0072520)	2.52972626
90	platelet dense granule organization (GO:0060155)	2.52577796
91	male meiosis I (GO:0007141)	2.52422353
92	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.51587241
93	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.51474817
94	proton transport (GO:0015992)	2.51307168
95	L-fucose catabolic process (GO:0042355)	2.50420821
96	fucose catabolic process (GO:0019317)	2.50420821
97	L-fucose metabolic process (GO:0042354)	2.50420821
98	negative regulation of membrane potential (GO:0045837)	2.49802583
99	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.49215263
100	isotype switching (GO:0045190)	2.49215263

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.96192643
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.52108677
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.81241169
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.30082547
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.22334599
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.20182326
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.19209305
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.12383078
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.83457148
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.76453919
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.73364540
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.41899475
13	FOXP3_21729870_ChIP-Seq_TREG_Human	2.32346884
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.22750614
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.15210635
16	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.12567924
17	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.01061123
18	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.98438957
19	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95804515
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.94924398
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.93986405
22	VDR_22108803_ChIP-Seq_LS180_Human	1.93727062
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.79561615
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.77716980
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.76384124
26	TTF2_22483619_ChIP-Seq_HELA_Human	1.76280602
27	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.75308750
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.70744451
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.67611258
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64704552
31	GABP_19822575_ChIP-Seq_HepG2_Human	1.62586743
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.62538949
33	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.60125100
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.57358668
35	EWS_26573619_Chip-Seq_HEK293_Human	1.48317859
36	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.47540740
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.43319481
38	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.42449684
39	DCP1A_22483619_ChIP-Seq_HELA_Human	1.42255333
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.39083514
41	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.36854415
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.32732067
43	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.32153134
44	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30948637
45	XRN2_22483619_ChIP-Seq_HELA_Human	1.30399302
46	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.28612269
47	TAF2_19829295_ChIP-Seq_ESCs_Human	1.28602130
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.27704205
49	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.27640100
50	FUS_26573619_Chip-Seq_HEK293_Human	1.27073988
51	ERA_21632823_ChIP-Seq_H3396_Human	1.22430364
52	MYC_19829295_ChIP-Seq_ESCs_Human	1.20409149
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19722522
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19722522
55	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.18124625
56	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.18061300
57	NCOR_22424771_ChIP-Seq_293T_Human	1.17170539
58	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.16495999
59	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.15334316
60	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.14489915
61	GATA3_26560356_Chip-Seq_TH2_Human	1.12880197
62	EZH2_22144423_ChIP-Seq_EOC_Human	1.12818407
63	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.10790471
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09497389
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08324141
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07606519
67	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07569493
68	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.06932230
69	IGF1R_20145208_ChIP-Seq_DFB_Human	1.06589935
70	ER_23166858_ChIP-Seq_MCF-7_Human	1.05621888
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05429528
72	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.03426058
73	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03232543
74	KDM5A_27292631_Chip-Seq_BREAST_Human	1.02879734
75	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01643922
76	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.99763893
77	BCAT_22108803_ChIP-Seq_LS180_Human	0.98798039
78	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98275459
79	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.98258993
80	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95380483
81	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95380483
82	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.95307658
83	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94866688
84	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.94836025
85	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.93110015
86	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.91617853
87	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.90699362
88	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.90390361
89	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.89523424
90	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.89233430
91	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.88836954
92	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.88631531
93	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.88352666
94	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.87851611
95	AR_20517297_ChIP-Seq_VCAP_Human	0.87640048
96	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.85969886
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.85787519
98	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.85612791
99	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.84783650
100	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.84520886

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	3.19983690
2	MP0003806_abnormal_nucleotide_metabolis	2.91645394
3	MP0003646_muscle_fatigue	2.86969614
4	MP0001986_abnormal_taste_sensitivity	2.81646133
5	MP0009379_abnormal_foot_pigmentation	2.77814136
6	MP0003693_abnormal_embryo_hatching	2.68734039
7	MP0002876_abnormal_thyroid_physiology	2.24255435
8	MP0003878_abnormal_ear_physiology	2.12927675
9	MP0005377_hearing/vestibular/ear_phenot	2.12927675
10	MP0005360_urolithiasis	2.08461290
11	MP0000427_abnormal_hair_cycle	2.06629458
12	MP0008875_abnormal_xenobiotic_pharmacok	2.04527577
13	MP0008789_abnormal_olfactory_epithelium	2.03627093
14	MP0008877_abnormal_DNA_methylation	2.02811951
15	MP0008872_abnormal_physiological_respon	1.98563755
16	MP0003195_calcinosis	1.97019045
17	MP0003786_premature_aging	1.94617059
18	MP0005084_abnormal_gallbladder_morpholo	1.87431069
19	MP0004147_increased_porphyrin_level	1.84831333
20	MP0005085_abnormal_gallbladder_physiolo	1.83761006
21	MP0002837_dystrophic_cardiac_calcinosis	1.74437999
22	MP0002102_abnormal_ear_morphology	1.69542803
23	MP0008058_abnormal_DNA_repair	1.68026528
24	MP0005551_abnormal_eye_electrophysiolog	1.66450178
25	MP0006036_abnormal_mitochondrial_physio	1.66415129
26	MP0003123_paternal_imprinting	1.62699301
27	MP0002160_abnormal_reproductive_system	1.57454626
28	MP0001666_abnormal_nutrient_absorption	1.56789249
29	MP0002095_abnormal_skin_pigmentation	1.56014454
30	MP0002938_white_spotting	1.54436532
31	MP0003252_abnormal_bile_duct	1.49897838
32	MP0002277_abnormal_respiratory_mucosa	1.49032855
33	MP0004142_abnormal_muscle_tone	1.47205897
34	MP0001293_anophthalmia	1.44127194
35	MP0001485_abnormal_pinna_reflex	1.44018208
36	MP0006292_abnormal_olfactory_placode	1.43189780
37	MP0003718_maternal_effect	1.43131899
38	MP0001905_abnormal_dopamine_level	1.37052609
39	MP0005174_abnormal_tail_pigmentation	1.32995203
40	MP0001984_abnormal_olfaction	1.32654455
41	MP0005389_reproductive_system_phenotype	1.32495231
42	MP0003011_delayed_dark_adaptation	1.30315953
43	MP0005408_hypopigmentation	1.28333869
44	MP0008775_abnormal_heart_ventricle	1.27013816
45	MP0001835_abnormal_antigen_presentation	1.25122439
46	MP0003567_abnormal_fetal_cardiomyocyte	1.21953674
47	MP0005365_abnormal_bile_salt	1.20420325
48	MP0001968_abnormal_touch/_nociception	1.18682059
49	MP0001529_abnormal_vocalization	1.14486106
50	MP0005645_abnormal_hypothalamus_physiol	1.13138333
51	MP0005670_abnormal_white_adipose	1.11984052
52	MP0002736_abnormal_nociception_after	1.11456158
53	MP0005367_renal/urinary_system_phenotyp	1.07522313
54	MP0000516_abnormal_urinary_system	1.07522313
55	MP0006072_abnormal_retinal_apoptosis	1.07322813
56	MP0001873_stomach_inflammation	1.04766302
57	MP0005646_abnormal_pituitary_gland	1.03043267
58	MP0005394_taste/olfaction_phenotype	1.02578717
59	MP0005499_abnormal_olfactory_system	1.02578717
60	MP0004885_abnormal_endolymph	1.02368633
61	MP0002210_abnormal_sex_determination	1.01609401
62	MP0010329_abnormal_lipoprotein_level	1.01573222
63	MP0004019_abnormal_vitamin_homeostasis	1.01222321
64	MP0002163_abnormal_gland_morphology	1.00510366
65	MP0005332_abnormal_amino_acid	1.00130805
66	MP0004145_abnormal_muscle_electrophysio	0.98406757
67	MP0000569_abnormal_digit_pigmentation	0.98358413
68	MP0002148_abnormal_hypersensitivity_rea	0.93417239
69	MP0001800_abnormal_humoral_immune	0.92879008
70	MP0008007_abnormal_cellular_replicative	0.91362634
71	MP0001929_abnormal_gametogenesis	0.90519315
72	MP0001119_abnormal_female_reproductive	0.90110724
73	MP0002138_abnormal_hepatobiliary_system	0.89194066
74	MP0001881_abnormal_mammary_gland	0.88991509
75	MP0003936_abnormal_reproductive_system	0.88539546
76	MP0006035_abnormal_mitochondrial_morpho	0.88268133
77	MP0005671_abnormal_response_to	0.87754707
78	MP0004742_abnormal_vestibular_system	0.86060961
79	MP0010155_abnormal_intestine_physiology	0.84036292
80	MP0000230_abnormal_systemic_arterial	0.83969446
81	MP0003787_abnormal_imprinting	0.83647053
82	MP0000383_abnormal_hair_follicle	0.83283069
83	MP0002233_abnormal_nose_morphology	0.82953748
84	MP0009765_abnormal_xenobiotic_induced	0.82339402
85	MP0005636_abnormal_mineral_homeostasis	0.82256707
86	MP0000653_abnormal_sex_gland	0.81079585
87	MP0000647_abnormal_sebaceous_gland	0.80804900
88	MP0004924_abnormal_behavior	0.79658712
89	MP0005386_behavior/neurological_phenoty	0.79658712
90	MP0005410_abnormal_fertilization	0.79216724
91	MP0002272_abnormal_nervous_system	0.78671012
92	MP0001764_abnormal_homeostasis	0.77837371
93	MP0003950_abnormal_plasma_membrane	0.76519827
94	MP0002733_abnormal_thermal_nociception	0.75433147
95	MP0001790_abnormal_immune_system	0.74430447
96	MP0005387_immune_system_phenotype	0.74430447
97	MP0006276_abnormal_autonomic_nervous	0.74366624
98	MP0003698_abnormal_male_reproductive	0.74363106
99	MP0003183_abnormal_peptide_metabolism	0.73094509
100	MP0002638_abnormal_pupillary_reflex	0.72102544

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.92927766
2	Mitochondrial inheritance (HP:0001427)	3.76428818
3	Acute encephalopathy (HP:0006846)	3.57208772
4	Methylmalonic aciduria (HP:0012120)	3.57202397
5	Hyperglycinemia (HP:0002154)	3.56049512
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.48609118
7	Hepatocellular necrosis (HP:0001404)	3.45924633
8	Progressive macrocephaly (HP:0004481)	3.44494820
9	Increased CSF lactate (HP:0002490)	3.40226320
10	Hepatic necrosis (HP:0002605)	3.26311031
11	Stomatitis (HP:0010280)	2.99285863
12	IgG deficiency (HP:0004315)	2.95270701
13	Congenital stationary night blindness (HP:0007642)	2.93553019
14	Methylmalonic acidemia (HP:0002912)	2.93233817
15	Cerebral edema (HP:0002181)	2.81148059
16	Abnormality of midbrain morphology (HP:0002418)	2.75550928
17	Molar tooth sign on MRI (HP:0002419)	2.75550928
18	Lethargy (HP:0001254)	2.72214048
19	Reticulocytopenia (HP:0001896)	2.68840682
20	Increased serum lactate (HP:0002151)	2.60716182
21	Lipid accumulation in hepatocytes (HP:0006561)	2.58436797
22	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.57299250
23	Dicarboxylic aciduria (HP:0003215)	2.57299250
24	Increased intramyocellular lipid droplets (HP:0012240)	2.56672267
25	Macrocytic anemia (HP:0001972)	2.54750622
26	Increased hepatocellular lipid droplets (HP:0006565)	2.53883731
27	Lactic acidosis (HP:0003128)	2.53771657
28	Chronic hepatic failure (HP:0100626)	2.52208994
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.50428281
30	Pancreatic cysts (HP:0001737)	2.50403112
31	Pancreatic fibrosis (HP:0100732)	2.48362948
32	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.48316941
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.46835659
34	Congenital, generalized hypertrichosis (HP:0004540)	2.46821987
35	Cutaneous melanoma (HP:0012056)	2.46361069
36	Renal Fanconi syndrome (HP:0001994)	2.41775721
37	Ketosis (HP:0001946)	2.39164754
38	True hermaphroditism (HP:0010459)	2.33022853
39	Abnormality of serine family amino acid metabolism (HP:0010894)	2.29589848
40	Abnormality of glycine metabolism (HP:0010895)	2.29589848
41	Abnormality of cells of the erythroid lineage (HP:0012130)	2.29556855
42	Type II lissencephaly (HP:0007260)	2.28957015
43	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.27682890
44	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.27682890
45	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.26610248
46	3-Methylglutaconic aciduria (HP:0003535)	2.24902640
47	Absent thumb (HP:0009777)	2.24154600
48	Increased muscle lipid content (HP:0009058)	2.23630257
49	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.22227470
50	Abnormality of alanine metabolism (HP:0010916)	2.22227470
51	Hyperalaninemia (HP:0003348)	2.22227470
52	Increased IgM level (HP:0003496)	2.21922953
53	Abnormal biliary tract physiology (HP:0012439)	2.19473341
54	Bile duct proliferation (HP:0001408)	2.19473341
55	Abnormality of macular pigmentation (HP:0008002)	2.15914951
56	Abnormality of urine glucose concentration (HP:0011016)	2.12383883
57	Glycosuria (HP:0003076)	2.12383883
58	Optic disc pallor (HP:0000543)	2.11596974
59	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.11061959
60	Type I transferrin isoform profile (HP:0003642)	2.09727106
61	Abnormality of vitamin B metabolism (HP:0004340)	2.06541071
62	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.05641723
63	Abnormality of serum amino acid levels (HP:0003112)	2.05273297
64	Pancytopenia (HP:0001876)	2.02170842
65	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.01824951
66	Abolished electroretinogram (ERG) (HP:0000550)	1.99542016
67	Hyperammonemia (HP:0001987)	1.98858080
68	Abnormal number of erythroid precursors (HP:0012131)	1.97859353
69	Chronic diarrhea (HP:0002028)	1.97253263
70	Agammaglobulinemia (HP:0004432)	1.97226766
71	IgA deficiency (HP:0002720)	1.97027313
72	Rib fusion (HP:0000902)	1.95810799
73	Respiratory failure (HP:0002878)	1.95243088
74	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.93520721
75	Absent/shortened dynein arms (HP:0200106)	1.93520721
76	Abnormality of dental color (HP:0011073)	1.93083007
77	Septo-optic dysplasia (HP:0100842)	1.92847169
78	Abnormality of renal resorption (HP:0011038)	1.92399428
79	Medial flaring of the eyebrow (HP:0010747)	1.91514930
80	Metabolic acidosis (HP:0001942)	1.90189270
81	Neutropenia (HP:0001875)	1.88019414
82	Sclerocornea (HP:0000647)	1.86040566
83	Panhypogammaglobulinemia (HP:0003139)	1.85613623
84	Nephronophthisis (HP:0000090)	1.85441727
85	Adrenal hypoplasia (HP:0000835)	1.84069034
86	Supernumerary spleens (HP:0009799)	1.82761314
87	Leukodystrophy (HP:0002415)	1.79041059
88	Large for gestational age (HP:0001520)	1.78427506
89	Male pseudohermaphroditism (HP:0000037)	1.78238817
90	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77727039
91	Hypoplasia of the radius (HP:0002984)	1.77090135
92	Vomiting (HP:0002013)	1.76959805
93	Proximal tubulopathy (HP:0000114)	1.76744808
94	Aplasia/hypoplasia of the uterus (HP:0008684)	1.76607375
95	Colon cancer (HP:0003003)	1.76439013
96	Exercise intolerance (HP:0003546)	1.74625145
97	Decreased central vision (HP:0007663)	1.71237737
98	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.69105533
99	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.67576241
100	Abnormality of the renal cortex (HP:0011035)	1.67452115

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.85463725
2	TAF1	3.63368986
3	FRK	3.47926768
4	STK16	3.38635381
5	ZAK	2.85232667
6	MAP4K2	2.56479338
7	VRK2	2.52212187
8	NUAK1	2.47225103
9	PDK2	2.37840622
10	BCKDK	2.35074492
11	GRK1	2.22246289
12	NME1	2.18302504
13	TLK1	2.17070074
14	STK39	1.93872656
15	TAOK3	1.89632548
16	WNK4	1.82790665
17	NEK1	1.79675624
18	ADRBK2	1.79336833
19	PIK3CA	1.77716741
20	MST4	1.75393793
21	TESK2	1.57606780
22	EIF2AK3	1.54657844
23	PBK	1.39242883
24	TRIM28	1.33976331
25	OXSR1	1.26863406
26	CASK	1.25700194
27	PLK3	1.23354051
28	GRK5	1.21016475
29	VRK1	1.17040115
30	BUB1	1.16816817
31	NME2	1.15924311
32	PLK2	1.11289853
33	EIF2AK2	1.07581845
34	IKBKB	1.04156928
35	PASK	1.02682581
36	PINK1	1.00610331
37	KIT	0.99760545
38	MAP3K14	0.99729289
39	DYRK2	0.98615505
40	WNK3	0.96485209
41	PIK3CG	0.92908250
42	RPS6KA5	0.92856199
43	TNIK	0.90065772
44	BMPR1B	0.88662454
45	MAPKAPK5	0.88182795
46	EPHB2	0.88061201
47	MAP3K13	0.87064702
48	WEE1	0.83774560
49	TSSK6	0.81859323
50	MKNK1	0.81316910
51	MATK	0.80129208
52	ACVR1B	0.78693090
53	TEC	0.78674295
54	ITK	0.77245876
55	MKNK2	0.76939059
56	MAP3K12	0.76159419
57	INSRR	0.74467436
58	PRKCQ	0.72883521
59	CSNK1G2	0.72600937
60	CSNK2A2	0.71929341
61	DAPK1	0.71143245
62	MAP2K6	0.67478262
63	CDK19	0.64362113
64	TIE1	0.63285841
65	PAK3	0.62262050
66	MAP4K1	0.61355606
67	MAP2K2	0.61304962
68	PRKCI	0.60486725
69	GRK6	0.57880149
70	PLK1	0.56999742
71	RPS6KA4	0.56483401
72	SRPK1	0.55669702
73	SYK	0.54928093
74	CSNK2A1	0.54917931
75	ATR	0.53027027
76	ADRBK1	0.51532937
77	PRKCG	0.49983363
78	AKT3	0.49640411
79	KDR	0.49287268
80	FLT3	0.48140680
81	CSNK1G3	0.47351327
82	CSNK1A1L	0.45249141
83	AURKB	0.44653172
84	EIF2AK1	0.43699098
85	BMPR2	0.42575367
86	MAPKAPK3	0.42344937
87	CAMK1	0.38426984
88	AURKA	0.37893254
89	PLK4	0.37854999
90	CSNK1G1	0.37452256
91	PRKCA	0.37110055
92	CSNK1A1	0.37010779
93	PRKCE	0.35426607
94	PRKCZ	0.35393843
95	IKBKE	0.34797843
96	LRRK2	0.32399270
97	OBSCN	0.31175379
98	MINK1	0.31027257
99	PRKACA	0.30631294
100	PRKCD	0.30163190

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.81028796
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.04307325
3	Proteasome_Homo sapiens_hsa03050	3.03249414
4	Parkinsons disease_Homo sapiens_hsa05012	2.49373804
5	Asthma_Homo sapiens_hsa05310	2.22871122
6	Protein export_Homo sapiens_hsa03060	2.22527161
7	Fat digestion and absorption_Homo sapiens_hsa04975	2.17120787
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.17108270
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.10007305
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.94806642
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.85569846
12	Caffeine metabolism_Homo sapiens_hsa00232	1.81270232
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.81149864
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.74927905
15	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.74588283
16	Homologous recombination_Homo sapiens_hsa03440	1.73927360
17	Peroxisome_Homo sapiens_hsa04146	1.69314151
18	Propanoate metabolism_Homo sapiens_hsa00640	1.67766564
19	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.60467074
20	Allograft rejection_Homo sapiens_hsa05330	1.59867764
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.59213345
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.59141051
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.57536358
24	Huntingtons disease_Homo sapiens_hsa05016	1.52786442
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.52176758
26	Alzheimers disease_Homo sapiens_hsa05010	1.48379828
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.47437907
28	Sulfur metabolism_Homo sapiens_hsa00920	1.46982244
29	DNA replication_Homo sapiens_hsa03030	1.43255086
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.40964815
31	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39930843
32	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.39825225
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.37907806
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.37178911
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.36451686
36	Mismatch repair_Homo sapiens_hsa03430	1.34644418
37	RNA polymerase_Homo sapiens_hsa03020	1.34315308
38	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.32620879
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.25968625
40	Base excision repair_Homo sapiens_hsa03410	1.23687065
41	Butanoate metabolism_Homo sapiens_hsa00650	1.21915624
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.18647164
43	RNA degradation_Homo sapiens_hsa03018	1.18477590
44	Retinol metabolism_Homo sapiens_hsa00830	1.17441007
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17364657
46	Selenocompound metabolism_Homo sapiens_hsa00450	1.14205190
47	Basal transcription factors_Homo sapiens_hsa03022	1.11295567
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.10880296
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10854925
50	Pyrimidine metabolism_Homo sapiens_hsa00240	1.10481660
51	Fatty acid degradation_Homo sapiens_hsa00071	1.10003642
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.08323671
53	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.08208710
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.08188042
55	Ether lipid metabolism_Homo sapiens_hsa00565	1.05113366
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01471601
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.92499169
58	Glutathione metabolism_Homo sapiens_hsa00480	0.91988609
59	Regulation of autophagy_Homo sapiens_hsa04140	0.91548069
60	Phototransduction_Homo sapiens_hsa04744	0.86810608
61	Arginine and proline metabolism_Homo sapiens_hsa00330	0.85794926
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83443261
63	Metabolic pathways_Homo sapiens_hsa01100	0.82387156
64	Purine metabolism_Homo sapiens_hsa00230	0.81211197
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80642207
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76782075
67	RNA transport_Homo sapiens_hsa03013	0.76095453
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.75687645
69	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.74402520
70	Sulfur relay system_Homo sapiens_hsa04122	0.74034414
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.73926150
72	One carbon pool by folate_Homo sapiens_hsa00670	0.71568745
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68687188
74	Graft-versus-host disease_Homo sapiens_hsa05332	0.67751460
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66332793
76	Type I diabetes mellitus_Homo sapiens_hsa04940	0.64401101
77	Antigen processing and presentation_Homo sapiens_hsa04612	0.64271237
78	Rheumatoid arthritis_Homo sapiens_hsa05323	0.63503383
79	Mineral absorption_Homo sapiens_hsa04978	0.59886085
80	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.59243111
81	Nitrogen metabolism_Homo sapiens_hsa00910	0.57689515
82	Non-homologous end-joining_Homo sapiens_hsa03450	0.56895981
83	Folate biosynthesis_Homo sapiens_hsa00790	0.56536727
84	Steroid biosynthesis_Homo sapiens_hsa00100	0.54116127
85	Fatty acid elongation_Homo sapiens_hsa00062	0.54041346
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.53714694
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52429654
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52389688
89	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.47417871
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46863414
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44699419
92	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.43924605
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.41556223
94	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.33082967
95	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.31819334
96	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.30872050
97	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.30406042
98	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.30228523
99	Arginine biosynthesis_Homo sapiens_hsa00220	0.29890727
100	Spliceosome_Homo sapiens_hsa03040	0.29884089

RPL12P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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