ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.14293379
2	viral transcription (GO:0019083)	7.04337663
3	translational termination (GO:0006415)	6.72880341
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.99965795
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.98032254
6	protein targeting to ER (GO:0045047)	5.89255904
7	cotranslational protein targeting to membrane (GO:0006613)	5.88797603
8	translational elongation (GO:0006414)	5.85938781
9	ribosomal small subunit biogenesis (GO:0042274)	5.84536023
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.73181566
11	ATP synthesis coupled proton transport (GO:0015986)	5.73181566
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.61598448
13	protein localization to endoplasmic reticulum (GO:0070972)	5.54643997
14	maturation of SSU-rRNA (GO:0030490)	5.31116714
15	viral life cycle (GO:0019058)	5.13292123
16	cellular protein complex disassembly (GO:0043624)	5.00537842
17	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.96337335
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.79586224
19	translational initiation (GO:0006413)	4.68309278
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.56405077
21	respiratory electron transport chain (GO:0022904)	4.53059239
22	electron transport chain (GO:0022900)	4.47929771
23	DNA deamination (GO:0045006)	4.38252588
24	ribosomal large subunit biogenesis (GO:0042273)	4.31803548
25	protein complex biogenesis (GO:0070271)	4.23533215
26	protein complex disassembly (GO:0043241)	4.14120830
27	water-soluble vitamin biosynthetic process (GO:0042364)	4.11727477
28	translation (GO:0006412)	4.10751769
29	cytidine metabolic process (GO:0046087)	4.09728607
30	cytidine catabolic process (GO:0006216)	4.09728607
31	cytidine deamination (GO:0009972)	4.09728607
32	protein neddylation (GO:0045116)	4.08937111
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.96001739
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.96001739
35	macromolecular complex disassembly (GO:0032984)	3.92880524
36	protein targeting to membrane (GO:0006612)	3.88110797
37	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.87028739
38	NADH dehydrogenase complex assembly (GO:0010257)	3.87028739
39	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.87028739
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.75909371
41	ribonucleoprotein complex biogenesis (GO:0022613)	3.54427849
42	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.51777349
43	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.48894383
44	cellular component biogenesis (GO:0044085)	3.47932598
45	chaperone-mediated protein transport (GO:0072321)	3.42123316
46	ATP biosynthetic process (GO:0006754)	3.41234863
47	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.38610294
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.38451021
49	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.38063809
50	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.31975484
51	mRNA catabolic process (GO:0006402)	3.30000454
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.28616275
53	GTP biosynthetic process (GO:0006183)	3.28022137
54	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.25253331
55	positive regulation of respiratory burst (GO:0060267)	3.24947004
56	peptidyl-histidine modification (GO:0018202)	3.22845511
57	hydrogen ion transmembrane transport (GO:1902600)	3.19199365
58	cytochrome complex assembly (GO:0017004)	3.18073737
59	signal peptide processing (GO:0006465)	3.17235664
60	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.14147575
61	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.02979640
62	response to pheromone (GO:0019236)	3.02665827
63	RNA catabolic process (GO:0006401)	3.02645751
64	response to interferon-beta (GO:0035456)	3.00419254
65	pseudouridine synthesis (GO:0001522)	2.96110473
66	respiratory chain complex IV assembly (GO:0008535)	2.95656505
67	proton transport (GO:0015992)	2.94800579
68	sulfation (GO:0051923)	2.93319734
69	hydrogen transport (GO:0006818)	2.86833648
70	positive regulation of prostaglandin secretion (GO:0032308)	2.85328798
71	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.78640561
72	proteasome assembly (GO:0043248)	2.75323743
73	rRNA processing (GO:0006364)	2.71991434
74	positive regulation of fatty acid transport (GO:2000193)	2.69888704
75	behavioral response to nicotine (GO:0035095)	2.69480974
76	rRNA metabolic process (GO:0016072)	2.69268320
77	UTP biosynthetic process (GO:0006228)	2.68803490
78	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.68135116
79	establishment of protein localization to membrane (GO:0090150)	2.66517121
80	regulation of immunoglobulin secretion (GO:0051023)	2.65311584
81	negative regulation of telomere maintenance (GO:0032205)	2.64698898
82	regulation of uterine smooth muscle contraction (GO:0070472)	2.64521081
83	termination of RNA polymerase III transcription (GO:0006386)	2.62728236
84	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.62728236
85	pyrimidine nucleotide catabolic process (GO:0006244)	2.60377402
86	regulation of cellular amino acid metabolic process (GO:0006521)	2.58759244
87	regulation of mitochondrial translation (GO:0070129)	2.56798470
88	cellular response to interferon-beta (GO:0035458)	2.56536266
89	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.56285297
90	intracellular protein transmembrane import (GO:0044743)	2.55848475
91	negative regulation of T cell differentiation in thymus (GO:0033085)	2.54614123
92	rRNA modification (GO:0000154)	2.54528792
93	platelet dense granule organization (GO:0060155)	2.52834574
94	regulation of regulatory T cell differentiation (GO:0045589)	2.51123572
95	cellular ketone body metabolic process (GO:0046950)	2.49410795
96	ribosome biogenesis (GO:0042254)	2.47581357
97	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.47124823
98	base-excision repair, AP site formation (GO:0006285)	2.45100651
99	autophagic vacuole fusion (GO:0000046)	2.44790438
100	nucleoside triphosphate biosynthetic process (GO:0009142)	2.44486154

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.14120882
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.89055685
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.63827625
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.56861139
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.55242329
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.54266819
7	EZH2_22144423_ChIP-Seq_EOC_Human	3.15150883
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.04545447
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.69804907
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.68638740
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.59782020
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.45185112
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.38045016
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.26147585
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.22406209
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.20525193
17	VDR_22108803_ChIP-Seq_LS180_Human	2.17697808
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.07795628
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.96967343
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.91239354
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.89984877
22	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.89253096
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.85410531
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65359505
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.61227929
26	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.59940110
27	TTF2_22483619_ChIP-Seq_HELA_Human	1.59833248
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52965988
29	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.51809734
30	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.51809734
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.48228096
32	EWS_26573619_Chip-Seq_HEK293_Human	1.46831253
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.44682537
34	AR_20517297_ChIP-Seq_VCAP_Human	1.42660948
35	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.42480198
36	NANOG_20526341_ChIP-Seq_ESCs_Human	1.41609906
37	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.41506209
38	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.41129817
39	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.35189311
40	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.34885802
41	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.34165784
42	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.33823619
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.33555075
44	NCOR_22424771_ChIP-Seq_293T_Human	1.32187753
45	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.28787857
46	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.28153186
47	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.27403901
48	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.26736884
49	P53_21459846_ChIP-Seq_SAOS-2_Human	1.26587497
50	TAF2_19829295_ChIP-Seq_ESCs_Human	1.25406552
51	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22917000
52	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.21609822
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20728082
54	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19936584
55	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.19463150
56	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.17980641
57	XRN2_22483619_ChIP-Seq_HELA_Human	1.17577315
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17349911
59	ERG_20517297_ChIP-Seq_VCAP_Human	1.17087972
60	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16561249
61	MYC_19829295_ChIP-Seq_ESCs_Human	1.16158269
62	ERA_21632823_ChIP-Seq_H3396_Human	1.15167796
63	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14032597
64	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.13643729
65	STAT1_20625510_ChIP-Seq_HELA_Human	1.12558789
66	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12542800
67	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.10736439
68	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10620219
69	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.08879260
70	FUS_26573619_Chip-Seq_HEK293_Human	1.08738230
71	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.06656213
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05752739
73	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.05192774
74	BCL6_27268052_Chip-Seq_Bcells_Human	1.04977067
75	GATA3_26560356_Chip-Seq_TH2_Human	1.04609122
76	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04248246
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03163958
78	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.02419580
79	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.01354958
80	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.01045200
81	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00384051
82	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00384051
83	CTCF_20526341_ChIP-Seq_ESCs_Human	1.00158721
84	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.99718197
85	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.99693040
86	BCAT_22108803_ChIP-Seq_LS180_Human	0.98759453
87	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.97912365
88	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.97237572
89	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.96818900
90	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94555412
91	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.93688119
92	RBPJ_21746931_ChIP-Seq_IB4_Human	0.93304818
93	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93269251
94	SA1_27219007_Chip-Seq_Bcells_Human	0.92683139
95	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.91609206
96	GABP_19822575_ChIP-Seq_HepG2_Human	0.91372164
97	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.91026109
98	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.90346915
99	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.88683212
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.88404610

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.36808801
2	MP0006292_abnormal_olfactory_placode	4.51477050
3	MP0005671_abnormal_response_to	2.79569321
4	MP0001835_abnormal_antigen_presentation	2.72408363
5	MP0002653_abnormal_ependyma_morphology	2.27561951
6	MP0002163_abnormal_gland_morphology	2.12806250
7	MP0008872_abnormal_physiological_respon	2.07302286
8	MP0008789_abnormal_olfactory_epithelium	2.06704010
9	MP0003806_abnormal_nucleotide_metabolis	2.04600568
10	MP0002638_abnormal_pupillary_reflex	1.92620067
11	MP0004147_increased_porphyrin_level	1.86905444
12	MP0005645_abnormal_hypothalamus_physiol	1.86792808
13	MP0002277_abnormal_respiratory_mucosa	1.84038397
14	MP0002822_catalepsy	1.81682217
15	MP0000372_irregular_coat_pigmentation	1.74637947
16	MP0005377_hearing/vestibular/ear_phenot	1.74012388
17	MP0003878_abnormal_ear_physiology	1.74012388
18	MP0008877_abnormal_DNA_methylation	1.73164212
19	MP0005646_abnormal_pituitary_gland	1.71120549
20	MP0009785_altered_susceptibility_to	1.69104908
21	MP0000685_abnormal_immune_system	1.54417877
22	MP0002138_abnormal_hepatobiliary_system	1.52636779
23	MP0002148_abnormal_hypersensitivity_rea	1.51989555
24	MP0008875_abnormal_xenobiotic_pharmacok	1.51224611
25	MP0005551_abnormal_eye_electrophysiolog	1.46445999
26	MP0001293_anophthalmia	1.43109177
27	MP0001800_abnormal_humoral_immune	1.42852640
28	MP0001764_abnormal_homeostasis	1.41863415
29	MP0004885_abnormal_endolymph	1.41739724
30	MP0004142_abnormal_muscle_tone	1.40670911
31	MP0002160_abnormal_reproductive_system	1.39972730
32	MP0005360_urolithiasis	1.39566588
33	MP0003646_muscle_fatigue	1.37163731
34	MP0005084_abnormal_gallbladder_morpholo	1.35273111
35	MP0003011_delayed_dark_adaptation	1.33813454
36	MP0001485_abnormal_pinna_reflex	1.33609495
37	MP0001968_abnormal_touch/_nociception	1.32468202
38	MP0005389_reproductive_system_phenotype	1.31524556
39	MP0005499_abnormal_olfactory_system	1.27305500
40	MP0005394_taste/olfaction_phenotype	1.27305500
41	MP0010155_abnormal_intestine_physiology	1.27221196
42	MP0005379_endocrine/exocrine_gland_phen	1.26842739
43	MP0006072_abnormal_retinal_apoptosis	1.25600621
44	MP0002095_abnormal_skin_pigmentation	1.25258580
45	MP0002234_abnormal_pharynx_morphology	1.23916651
46	MP0002938_white_spotting	1.23823904
47	MP0001873_stomach_inflammation	1.22077373
48	MP0002876_abnormal_thyroid_physiology	1.19612793
49	MP0005387_immune_system_phenotype	1.18277163
50	MP0001790_abnormal_immune_system	1.18277163
51	MP0004145_abnormal_muscle_electrophysio	1.17426630
52	MP0002102_abnormal_ear_morphology	1.16079672
53	MP0001905_abnormal_dopamine_level	1.14664469
54	MP0002736_abnormal_nociception_after	1.14077395
55	MP0001919_abnormal_reproductive_system	1.12291035
56	MP0003787_abnormal_imprinting	1.11061504
57	MP0003866_abnormal_defecation	1.11008765
58	MP0003786_premature_aging	1.09718728
59	MP0001663_abnormal_digestive_system	1.06893413
60	MP0002723_abnormal_immune_serum	1.06740889
61	MP0004019_abnormal_vitamin_homeostasis	1.05973575
62	MP0008995_early_reproductive_senescence	1.04507709
63	MP0001986_abnormal_taste_sensitivity	1.01173064
64	MP0000631_abnormal_neuroendocrine_gland	1.00823291
65	MP0005075_abnormal_melanosome_morpholog	1.00632068
66	MP0003718_maternal_effect	1.00269819
67	MP0003136_yellow_coat_color	1.00229716
68	MP0005025_abnormal_response_to	0.99374406
69	MP0006036_abnormal_mitochondrial_physio	0.97444513
70	MP0009333_abnormal_splenocyte_physiolog	0.96968876
71	MP0005174_abnormal_tail_pigmentation	0.96553548
72	MP0002420_abnormal_adaptive_immunity	0.96170638
73	MP0005000_abnormal_immune_tolerance	0.94011148
74	MP0001348_abnormal_lacrimal_gland	0.93913527
75	MP0001819_abnormal_immune_cell	0.92542034
76	MP0001666_abnormal_nutrient_absorption	0.91904761
77	MP0001984_abnormal_olfaction	0.91056693
78	MP0000049_abnormal_middle_ear	0.89918044
79	MP0003186_abnormal_redox_activity	0.89428197
80	MP0009764_decreased_sensitivity_to	0.88279659
81	MP0003195_calcinosis	0.85816129
82	MP0002272_abnormal_nervous_system	0.85572610
83	MP0005253_abnormal_eye_physiology	0.84749473
84	MP0003938_abnormal_ear_development	0.84601371
85	MP0004133_heterotaxia	0.84267500
86	MP0005636_abnormal_mineral_homeostasis	0.83901530
87	MP0005085_abnormal_gallbladder_physiolo	0.83776477
88	MP0000716_abnormal_immune_system	0.80564120
89	MP0002452_abnormal_antigen_presenting	0.79974746
90	MP0004043_abnormal_pH_regulation	0.79717276
91	MP0001188_hyperpigmentation	0.77734485
92	MP0002837_dystrophic_cardiac_calcinosis	0.76620038
93	MP0005410_abnormal_fertilization	0.76029372
94	MP0001853_heart_inflammation	0.75793169
95	MP0001529_abnormal_vocalization	0.74840006
96	MP0001845_abnormal_inflammatory_respons	0.74785591
97	MP0003693_abnormal_embryo_hatching	0.74235700
98	MP0003880_abnormal_central_pattern	0.72243182
99	MP0003638_abnormal_response/metabolism_	0.72028279
100	MP0002735_abnormal_chemical_nociception	0.71423831

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.78365280
2	3-Methylglutaconic aciduria (HP:0003535)	4.56946939
3	Mitochondrial inheritance (HP:0001427)	4.36412095
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.26769170
5	Reticulocytopenia (HP:0001896)	4.14367468
6	Acute encephalopathy (HP:0006846)	4.08893243
7	Progressive macrocephaly (HP:0004481)	3.94395996
8	Increased CSF lactate (HP:0002490)	3.88185282
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.79581023
10	Hepatocellular necrosis (HP:0001404)	3.77193532
11	Increased hepatocellular lipid droplets (HP:0006565)	3.75783222
12	Lipid accumulation in hepatocytes (HP:0006561)	3.65689242
13	Macrocytic anemia (HP:0001972)	3.56869807
14	Hepatic necrosis (HP:0002605)	3.46613995
15	Pancreatic cysts (HP:0001737)	3.44222724
16	Cerebral edema (HP:0002181)	3.40239302
17	Stomatitis (HP:0010280)	3.30149347
18	Abnormal number of erythroid precursors (HP:0012131)	3.29464181
19	Increased IgM level (HP:0003496)	3.14424142
20	IgG deficiency (HP:0004315)	3.12384980
21	Renal Fanconi syndrome (HP:0001994)	3.11232513
22	True hermaphroditism (HP:0010459)	3.10728160
23	Elevated erythrocyte sedimentation rate (HP:0003565)	3.10482723
24	Congenital stationary night blindness (HP:0007642)	3.09631596
25	Optic disc pallor (HP:0000543)	3.04524434
26	Pancreatic fibrosis (HP:0100732)	2.97771643
27	Aplastic anemia (HP:0001915)	2.97743860
28	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.97722499
29	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.88959616
30	Increased intramyocellular lipid droplets (HP:0012240)	2.85200292
31	Molar tooth sign on MRI (HP:0002419)	2.84213356
32	Abnormality of midbrain morphology (HP:0002418)	2.84213356
33	Exertional dyspnea (HP:0002875)	2.78671083
34	Colon cancer (HP:0003003)	2.72407916
35	Increased muscle lipid content (HP:0009058)	2.61748933
36	Lactic acidosis (HP:0003128)	2.60092093
37	Increased serum lactate (HP:0002151)	2.53453613
38	Abnormality of urine glucose concentration (HP:0011016)	2.52983283
39	Glycosuria (HP:0003076)	2.52983283
40	Abolished electroretinogram (ERG) (HP:0000550)	2.52257630
41	Nephronophthisis (HP:0000090)	2.48802392
42	Pallor (HP:0000980)	2.46157618
43	Lethargy (HP:0001254)	2.45387512
44	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.43609864
45	Respiratory failure (HP:0002878)	2.37815896
46	Septo-optic dysplasia (HP:0100842)	2.35115558
47	Abnormal rod and cone electroretinograms (HP:0008323)	2.32433585
48	Abnormal ciliary motility (HP:0012262)	2.28708359
49	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.25166145
50	Hyperglycinemia (HP:0002154)	2.23723311
51	Abnormality of the renal cortex (HP:0011035)	2.21131849
52	Respiratory difficulties (HP:0002880)	2.20387482
53	Medial flaring of the eyebrow (HP:0010747)	2.19979482
54	Congenital, generalized hypertrichosis (HP:0004540)	2.19647895
55	Abnormal respiratory motile cilium physiology (HP:0012261)	2.18439061
56	Exercise intolerance (HP:0003546)	2.17424334
57	Sclerocornea (HP:0000647)	2.14808182
58	Partial duplication of thumb phalanx (HP:0009944)	2.14165696
59	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.13250348
60	Dicarboxylic aciduria (HP:0003215)	2.13250348
61	Stenosis of the external auditory canal (HP:0000402)	2.12519623
62	Attenuation of retinal blood vessels (HP:0007843)	2.12303704
63	Absent thumb (HP:0009777)	2.11390213
64	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.09126722
65	Absent/shortened dynein arms (HP:0200106)	2.09126722
66	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.08591956
67	Decreased central vision (HP:0007663)	2.08310325
68	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.07583083
69	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.07583083
70	Cystic liver disease (HP:0006706)	2.07076596
71	Hyperphosphaturia (HP:0003109)	2.05293965
72	Abnormality of renal resorption (HP:0011038)	2.02384501
73	Abnormality of the renal medulla (HP:0100957)	2.01952465
74	Bile duct proliferation (HP:0001408)	1.98787275
75	Abnormal biliary tract physiology (HP:0012439)	1.98787275
76	Methylmalonic aciduria (HP:0012120)	1.95901556
77	Aplasia/hypoplasia of the uterus (HP:0008684)	1.94823511
78	Pancytopenia (HP:0001876)	1.92329626
79	Hypoplasia of the radius (HP:0002984)	1.92071183
80	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.91810898
81	Abnormal respiratory epithelium morphology (HP:0012253)	1.91533907
82	Abnormal respiratory motile cilium morphology (HP:0005938)	1.91533907
83	Type 2 muscle fiber atrophy (HP:0003554)	1.90980145
84	Leukodystrophy (HP:0002415)	1.90526344
85	Postaxial foot polydactyly (HP:0001830)	1.89973673
86	Confusion (HP:0001289)	1.88659863
87	Panhypogammaglobulinemia (HP:0003139)	1.88256568
88	Male pseudohermaphroditism (HP:0000037)	1.86503392
89	Abnormality of T cells (HP:0002843)	1.86092833
90	Partial duplication of the phalanx of hand (HP:0009999)	1.85499009
91	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.84304009
92	Abnormality of B cell number (HP:0010975)	1.83564695
93	Hyperglycinuria (HP:0003108)	1.83252921
94	Pendular nystagmus (HP:0012043)	1.82462704
95	Abnormality of T cell physiology (HP:0011840)	1.79416478
96	Renal cortical cysts (HP:0000803)	1.78868031
97	Constricted visual fields (HP:0001133)	1.78439505
98	Generalized aminoaciduria (HP:0002909)	1.76945710
99	Severe combined immunodeficiency (HP:0004430)	1.75554920
100	Methylmalonic acidemia (HP:0002912)	1.74657381

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.73094264
2	TXK	3.35031232
3	CDK19	3.03651850
4	TAOK3	3.00959775
5	TLK1	2.90232309
6	KDR	2.63048495
7	ZAK	2.54662386
8	ADRBK2	2.48818608
9	WNK4	2.43811771
10	PASK	2.41811662
11	NUAK1	2.27449336
12	GRK1	2.26496022
13	BCKDK	2.22455841
14	NME1	2.17315776
15	PINK1	1.80971809
16	TEC	1.78122465
17	NME2	1.76787729
18	FRK	1.73841904
19	VRK1	1.71870844
20	PBK	1.70264678
21	TIE1	1.70149660
22	BMPR1B	1.68652552
23	MAP4K2	1.63689328
24	MAP4K1	1.56518800
25	DYRK2	1.48891160
26	STK16	1.41918343
27	TESK2	1.40417073
28	MAP3K12	1.34092834
29	KIT	1.31743201
30	MUSK	1.23857669
31	WNK3	1.22539850
32	INSRR	1.21080652
33	ACVR1B	1.18856600
34	MAPKAPK5	1.18287774
35	ITK	1.16992590
36	STK39	1.10787773
37	TAF1	1.04957012
38	ADRBK1	1.03135168
39	FES	0.97768900
40	MST4	0.97519313
41	IKBKB	0.94530478
42	LRRK2	0.92838186
43	EIF2AK1	0.92315530
44	SCYL2	0.92228610
45	OXSR1	0.89092509
46	PRKCQ	0.85121565
47	PIK3CG	0.83529544
48	GRK6	0.82188663
49	SYK	0.82160127
50	DAPK3	0.82128924
51	MAP3K11	0.80768533
52	LIMK1	0.78915274
53	DAPK1	0.78162054
54	DAPK2	0.73707903
55	RPS6KB2	0.73055623
56	PLK4	0.71292138
57	EIF2AK3	0.70442543
58	BTK	0.65458733
59	LCK	0.65338627
60	RPS6KA5	0.64895864
61	PRKCG	0.64754737
62	OBSCN	0.64424542
63	CDC7	0.63257204
64	MYLK	0.60584327
65	IKBKE	0.59518502
66	GRK5	0.59130711
67	CSNK2A2	0.58723392
68	CAMKK1	0.57548761
69	NEK1	0.56592429
70	PIK3CA	0.51185656
71	TGFBR1	0.49976077
72	PRKCA	0.48905716
73	TSSK6	0.48620291
74	BUB1	0.48248354
75	TYK2	0.48046560
76	WNK1	0.47101246
77	CSNK2A1	0.46619920
78	PRKACA	0.46423234
79	MAPKAPK3	0.46290001
80	ABL2	0.45836706
81	LYN	0.45109380
82	MAP2K6	0.44822367
83	CAMK1	0.44584527
84	PLK3	0.44276884
85	AURKB	0.43916780
86	JAK3	0.43636269
87	ATR	0.43588594
88	CAMKK2	0.42395677
89	CSK	0.41639783
90	TNIK	0.40826599
91	PRKCD	0.40739632
92	PRKCH	0.40082326
93	MAPK15	0.40023613
94	PRKCE	0.39838043
95	ILK	0.38328748
96	PLK2	0.35798415
97	SRPK1	0.34860861
98	MATK	0.34272235
99	IGF1R	0.32699878
100	PIM1	0.32074985

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.58500423
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.10518028
3	Parkinsons disease_Homo sapiens_hsa05012	3.47301597
4	Proteasome_Homo sapiens_hsa03050	3.22857723
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.77718546
6	Asthma_Homo sapiens_hsa05310	2.36054361
7	Huntingtons disease_Homo sapiens_hsa05016	2.31054213
8	Alzheimers disease_Homo sapiens_hsa05010	2.25649192
9	RNA polymerase_Homo sapiens_hsa03020	2.21765087
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.08530780
11	Protein export_Homo sapiens_hsa03060	2.05465707
12	Allograft rejection_Homo sapiens_hsa05330	2.02149645
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.01124964
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96881610
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.96752231
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.82922802
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.77229325
18	Homologous recombination_Homo sapiens_hsa03440	1.57897190
19	Phototransduction_Homo sapiens_hsa04744	1.57098454
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.48983827
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.43375725
22	Fat digestion and absorption_Homo sapiens_hsa04975	1.35168966
23	RNA degradation_Homo sapiens_hsa03018	1.33947918
24	Antigen processing and presentation_Homo sapiens_hsa04612	1.33821775
25	Caffeine metabolism_Homo sapiens_hsa00232	1.31024747
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.30722956
27	Type I diabetes mellitus_Homo sapiens_hsa04940	1.30067313
28	DNA replication_Homo sapiens_hsa03030	1.29891629
29	Retinol metabolism_Homo sapiens_hsa00830	1.28714751
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.27944691
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.26412358
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.26146592
33	Peroxisome_Homo sapiens_hsa04146	1.25026479
34	Mismatch repair_Homo sapiens_hsa03430	1.23542218
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.18828238
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.15703731
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.10703204
38	Propanoate metabolism_Homo sapiens_hsa00640	1.07605343
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06797308
40	Butanoate metabolism_Homo sapiens_hsa00650	1.02794107
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.02374414
42	Base excision repair_Homo sapiens_hsa03410	1.01815699
43	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.01210543
44	One carbon pool by folate_Homo sapiens_hsa00670	1.00953467
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.97704150
46	Ether lipid metabolism_Homo sapiens_hsa00565	0.97248326
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.96583778
48	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.95883024
49	Purine metabolism_Homo sapiens_hsa00230	0.95517170
50	Fanconi anemia pathway_Homo sapiens_hsa03460	0.93250144
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.88951486
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88728126
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88233393
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.87479231
55	Spliceosome_Homo sapiens_hsa03040	0.85495241
56	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.83782991
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83726105
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80632772
59	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.79654878
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.77663705
61	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.77473277
62	Basal transcription factors_Homo sapiens_hsa03022	0.77110719
63	Glutathione metabolism_Homo sapiens_hsa00480	0.71196013
64	Rheumatoid arthritis_Homo sapiens_hsa05323	0.71067888
65	Metabolic pathways_Homo sapiens_hsa01100	0.70258151
66	Folate biosynthesis_Homo sapiens_hsa00790	0.69735966
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.64579534
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64162018
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.61921787
70	Fatty acid elongation_Homo sapiens_hsa00062	0.61429585
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.60487920
72	Mineral absorption_Homo sapiens_hsa04978	0.59703209
73	RNA transport_Homo sapiens_hsa03013	0.58397596
74	Fatty acid degradation_Homo sapiens_hsa00071	0.58156636
75	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56897045
76	Olfactory transduction_Homo sapiens_hsa04740	0.51648279
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.48961933
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47089721
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46466457
80	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.46055161
81	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.44491496
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.44203062
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43640138
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.38394852
85	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.37771912
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.36391252
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35515227
88	Taste transduction_Homo sapiens_hsa04742	0.34826801
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33843306
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.33174143
91	Sulfur metabolism_Homo sapiens_hsa00920	0.29318089
92	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.25260851
93	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.25109213
94	Arginine biosynthesis_Homo sapiens_hsa00220	0.22365289
95	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.20236353
96	Regulation of autophagy_Homo sapiens_hsa04140	0.17009018
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.16595097
98	Protein digestion and absorption_Homo sapiens_hsa04974	0.15756042
99	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.14205944
100	Viral myocarditis_Homo sapiens_hsa05416	0.11928779

RPL12P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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