RPL12P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.14293379
2viral transcription (GO:0019083)7.04337663
3translational termination (GO:0006415)6.72880341
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.99965795
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.98032254
6protein targeting to ER (GO:0045047)5.89255904
7cotranslational protein targeting to membrane (GO:0006613)5.88797603
8translational elongation (GO:0006414)5.85938781
9ribosomal small subunit biogenesis (GO:0042274)5.84536023
10ATP synthesis coupled proton transport (GO:0015986)5.73181566
11energy coupled proton transport, down electrochemical gradient (GO:0015985)5.73181566
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.61598448
13protein localization to endoplasmic reticulum (GO:0070972)5.54643997
14maturation of SSU-rRNA (GO:0030490)5.31116714
15viral life cycle (GO:0019058)5.13292123
16cellular protein complex disassembly (GO:0043624)5.00537842
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.96337335
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.79586224
19translational initiation (GO:0006413)4.68309278
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.56405077
21respiratory electron transport chain (GO:0022904)4.53059239
22electron transport chain (GO:0022900)4.47929771
23DNA deamination (GO:0045006)4.38252588
24ribosomal large subunit biogenesis (GO:0042273)4.31803548
25protein complex biogenesis (GO:0070271)4.23533215
26protein complex disassembly (GO:0043241)4.14120830
27water-soluble vitamin biosynthetic process (GO:0042364)4.11727477
28translation (GO:0006412)4.10751769
29cytidine metabolic process (GO:0046087)4.09728607
30cytidine catabolic process (GO:0006216)4.09728607
31cytidine deamination (GO:0009972)4.09728607
32protein neddylation (GO:0045116)4.08937111
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.96001739
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.96001739
35macromolecular complex disassembly (GO:0032984)3.92880524
36protein targeting to membrane (GO:0006612)3.88110797
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.87028739
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.87028739
39NADH dehydrogenase complex assembly (GO:0010257)3.87028739
40mitochondrial respiratory chain complex assembly (GO:0033108)3.75909371
41ribonucleoprotein complex biogenesis (GO:0022613)3.54427849
42pyrimidine ribonucleoside catabolic process (GO:0046133)3.51777349
43nuclear-transcribed mRNA catabolic process (GO:0000956)3.48894383
44cellular component biogenesis (GO:0044085)3.47932598
45chaperone-mediated protein transport (GO:0072321)3.42123316
46ATP biosynthetic process (GO:0006754)3.41234863
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38610294
48purine nucleoside triphosphate biosynthetic process (GO:0009145)3.38451021
49purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.38063809
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31975484
51mRNA catabolic process (GO:0006402)3.30000454
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.28616275
53GTP biosynthetic process (GO:0006183)3.28022137
54positive regulation of uterine smooth muscle contraction (GO:0070474)3.25253331
55positive regulation of respiratory burst (GO:0060267)3.24947004
56peptidyl-histidine modification (GO:0018202)3.22845511
57hydrogen ion transmembrane transport (GO:1902600)3.19199365
58cytochrome complex assembly (GO:0017004)3.18073737
59signal peptide processing (GO:0006465)3.17235664
60pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.14147575
61positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.02979640
62response to pheromone (GO:0019236)3.02665827
63RNA catabolic process (GO:0006401)3.02645751
64response to interferon-beta (GO:0035456)3.00419254
65pseudouridine synthesis (GO:0001522)2.96110473
66respiratory chain complex IV assembly (GO:0008535)2.95656505
67proton transport (GO:0015992)2.94800579
68sulfation (GO:0051923)2.93319734
69hydrogen transport (GO:0006818)2.86833648
70positive regulation of prostaglandin secretion (GO:0032308)2.85328798
71ribonucleoside triphosphate biosynthetic process (GO:0009201)2.78640561
72proteasome assembly (GO:0043248)2.75323743
73rRNA processing (GO:0006364)2.71991434
74positive regulation of fatty acid transport (GO:2000193)2.69888704
75behavioral response to nicotine (GO:0035095)2.69480974
76rRNA metabolic process (GO:0016072)2.69268320
77UTP biosynthetic process (GO:0006228)2.68803490
78regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.68135116
79establishment of protein localization to membrane (GO:0090150)2.66517121
80regulation of immunoglobulin secretion (GO:0051023)2.65311584
81negative regulation of telomere maintenance (GO:0032205)2.64698898
82regulation of uterine smooth muscle contraction (GO:0070472)2.64521081
83transcription elongation from RNA polymerase III promoter (GO:0006385)2.62728236
84termination of RNA polymerase III transcription (GO:0006386)2.62728236
85pyrimidine nucleotide catabolic process (GO:0006244)2.60377402
86regulation of cellular amino acid metabolic process (GO:0006521)2.58759244
87regulation of mitochondrial translation (GO:0070129)2.56798470
88cellular response to interferon-beta (GO:0035458)2.56536266
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.56285297
90intracellular protein transmembrane import (GO:0044743)2.55848475
91negative regulation of T cell differentiation in thymus (GO:0033085)2.54614123
92rRNA modification (GO:0000154)2.54528792
93platelet dense granule organization (GO:0060155)2.52834574
94regulation of regulatory T cell differentiation (GO:0045589)2.51123572
95cellular ketone body metabolic process (GO:0046950)2.49410795
96ribosome biogenesis (GO:0042254)2.47581357
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.47124823
98base-excision repair, AP site formation (GO:0006285)2.45100651
99autophagic vacuole fusion (GO:0000046)2.44790438
100nucleoside triphosphate biosynthetic process (GO:0009142)2.44486154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.14120882
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.89055685
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.63827625
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.56861139
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55242329
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.54266819
7EZH2_22144423_ChIP-Seq_EOC_Human3.15150883
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.04545447
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69804907
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.68638740
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59782020
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45185112
13VDR_23849224_ChIP-Seq_CD4+_Human2.38045016
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26147585
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.22406209
16ZNF274_21170338_ChIP-Seq_K562_Hela2.20525193
17VDR_22108803_ChIP-Seq_LS180_Human2.17697808
18FOXP3_21729870_ChIP-Seq_TREG_Human2.07795628
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96967343
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91239354
21MYC_18940864_ChIP-ChIP_HL60_Human1.89984877
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.89253096
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85410531
24ELK1_19687146_ChIP-ChIP_HELA_Human1.65359505
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.61227929
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59940110
27TTF2_22483619_ChIP-Seq_HELA_Human1.59833248
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52965988
29FOXA1_27270436_Chip-Seq_PROSTATE_Human1.51809734
30FOXA1_25329375_ChIP-Seq_VCAP_Human1.51809734
31IGF1R_20145208_ChIP-Seq_DFB_Human1.48228096
32EWS_26573619_Chip-Seq_HEK293_Human1.46831253
33TP53_22573176_ChIP-Seq_HFKS_Human1.44682537
34AR_20517297_ChIP-Seq_VCAP_Human1.42660948
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42480198
36NANOG_20526341_ChIP-Seq_ESCs_Human1.41609906
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41506209
38CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41129817
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35189311
40RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.34885802
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34165784
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33823619
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33555075
44NCOR_22424771_ChIP-Seq_293T_Human1.32187753
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.28787857
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28153186
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27403901
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26736884
49P53_21459846_ChIP-Seq_SAOS-2_Human1.26587497
50TAF2_19829295_ChIP-Seq_ESCs_Human1.25406552
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.22917000
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.21609822
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20728082
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.19936584
55CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19463150
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17980641
57XRN2_22483619_ChIP-Seq_HELA_Human1.17577315
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17349911
59ERG_20517297_ChIP-Seq_VCAP_Human1.17087972
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16561249
61MYC_19829295_ChIP-Seq_ESCs_Human1.16158269
62ERA_21632823_ChIP-Seq_H3396_Human1.15167796
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14032597
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13643729
65STAT1_20625510_ChIP-Seq_HELA_Human1.12558789
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12542800
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10736439
68FOXH1_21741376_ChIP-Seq_EPCs_Human1.10620219
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08879260
70FUS_26573619_Chip-Seq_HEK293_Human1.08738230
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06656213
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05752739
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05192774
74BCL6_27268052_Chip-Seq_Bcells_Human1.04977067
75GATA3_26560356_Chip-Seq_TH2_Human1.04609122
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04248246
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03163958
78MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02419580
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01354958
80EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01045200
81SOX2_19829295_ChIP-Seq_ESCs_Human1.00384051
82NANOG_19829295_ChIP-Seq_ESCs_Human1.00384051
83CTCF_20526341_ChIP-Seq_ESCs_Human1.00158721
84HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99718197
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99693040
86BCAT_22108803_ChIP-Seq_LS180_Human0.98759453
87PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97912365
88YY1_22570637_ChIP-Seq_MALME-3M_Human0.97237572
89BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96818900
90TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94555412
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.93688119
92RBPJ_21746931_ChIP-Seq_IB4_Human0.93304818
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.93269251
94SA1_27219007_Chip-Seq_Bcells_Human0.92683139
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91609206
96GABP_19822575_ChIP-Seq_HepG2_Human0.91372164
97TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91026109
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90346915
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88683212
100HOXB7_26014856_ChIP-Seq_BT474_Human0.88404610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.36808801
2MP0006292_abnormal_olfactory_placode4.51477050
3MP0005671_abnormal_response_to2.79569321
4MP0001835_abnormal_antigen_presentation2.72408363
5MP0002653_abnormal_ependyma_morphology2.27561951
6MP0002163_abnormal_gland_morphology2.12806250
7MP0008872_abnormal_physiological_respon2.07302286
8MP0008789_abnormal_olfactory_epithelium2.06704010
9MP0003806_abnormal_nucleotide_metabolis2.04600568
10MP0002638_abnormal_pupillary_reflex1.92620067
11MP0004147_increased_porphyrin_level1.86905444
12MP0005645_abnormal_hypothalamus_physiol1.86792808
13MP0002277_abnormal_respiratory_mucosa1.84038397
14MP0002822_catalepsy1.81682217
15MP0000372_irregular_coat_pigmentation1.74637947
16MP0005377_hearing/vestibular/ear_phenot1.74012388
17MP0003878_abnormal_ear_physiology1.74012388
18MP0008877_abnormal_DNA_methylation1.73164212
19MP0005646_abnormal_pituitary_gland1.71120549
20MP0009785_altered_susceptibility_to1.69104908
21MP0000685_abnormal_immune_system1.54417877
22MP0002138_abnormal_hepatobiliary_system1.52636779
23MP0002148_abnormal_hypersensitivity_rea1.51989555
24MP0008875_abnormal_xenobiotic_pharmacok1.51224611
25MP0005551_abnormal_eye_electrophysiolog1.46445999
26MP0001293_anophthalmia1.43109177
27MP0001800_abnormal_humoral_immune1.42852640
28MP0001764_abnormal_homeostasis1.41863415
29MP0004885_abnormal_endolymph1.41739724
30MP0004142_abnormal_muscle_tone1.40670911
31MP0002160_abnormal_reproductive_system1.39972730
32MP0005360_urolithiasis1.39566588
33MP0003646_muscle_fatigue1.37163731
34MP0005084_abnormal_gallbladder_morpholo1.35273111
35MP0003011_delayed_dark_adaptation1.33813454
36MP0001485_abnormal_pinna_reflex1.33609495
37MP0001968_abnormal_touch/_nociception1.32468202
38MP0005389_reproductive_system_phenotype1.31524556
39MP0005499_abnormal_olfactory_system1.27305500
40MP0005394_taste/olfaction_phenotype1.27305500
41MP0010155_abnormal_intestine_physiology1.27221196
42MP0005379_endocrine/exocrine_gland_phen1.26842739
43MP0006072_abnormal_retinal_apoptosis1.25600621
44MP0002095_abnormal_skin_pigmentation1.25258580
45MP0002234_abnormal_pharynx_morphology1.23916651
46MP0002938_white_spotting1.23823904
47MP0001873_stomach_inflammation1.22077373
48MP0002876_abnormal_thyroid_physiology1.19612793
49MP0005387_immune_system_phenotype1.18277163
50MP0001790_abnormal_immune_system1.18277163
51MP0004145_abnormal_muscle_electrophysio1.17426630
52MP0002102_abnormal_ear_morphology1.16079672
53MP0001905_abnormal_dopamine_level1.14664469
54MP0002736_abnormal_nociception_after1.14077395
55MP0001919_abnormal_reproductive_system1.12291035
56MP0003787_abnormal_imprinting1.11061504
57MP0003866_abnormal_defecation1.11008765
58MP0003786_premature_aging1.09718728
59MP0001663_abnormal_digestive_system1.06893413
60MP0002723_abnormal_immune_serum1.06740889
61MP0004019_abnormal_vitamin_homeostasis1.05973575
62MP0008995_early_reproductive_senescence1.04507709
63MP0001986_abnormal_taste_sensitivity1.01173064
64MP0000631_abnormal_neuroendocrine_gland1.00823291
65MP0005075_abnormal_melanosome_morpholog1.00632068
66MP0003718_maternal_effect1.00269819
67MP0003136_yellow_coat_color1.00229716
68MP0005025_abnormal_response_to0.99374406
69MP0006036_abnormal_mitochondrial_physio0.97444513
70MP0009333_abnormal_splenocyte_physiolog0.96968876
71MP0005174_abnormal_tail_pigmentation0.96553548
72MP0002420_abnormal_adaptive_immunity0.96170638
73MP0005000_abnormal_immune_tolerance0.94011148
74MP0001348_abnormal_lacrimal_gland0.93913527
75MP0001819_abnormal_immune_cell0.92542034
76MP0001666_abnormal_nutrient_absorption0.91904761
77MP0001984_abnormal_olfaction0.91056693
78MP0000049_abnormal_middle_ear0.89918044
79MP0003186_abnormal_redox_activity0.89428197
80MP0009764_decreased_sensitivity_to0.88279659
81MP0003195_calcinosis0.85816129
82MP0002272_abnormal_nervous_system0.85572610
83MP0005253_abnormal_eye_physiology0.84749473
84MP0003938_abnormal_ear_development0.84601371
85MP0004133_heterotaxia0.84267500
86MP0005636_abnormal_mineral_homeostasis0.83901530
87MP0005085_abnormal_gallbladder_physiolo0.83776477
88MP0000716_abnormal_immune_system0.80564120
89MP0002452_abnormal_antigen_presenting0.79974746
90MP0004043_abnormal_pH_regulation0.79717276
91MP0001188_hyperpigmentation0.77734485
92MP0002837_dystrophic_cardiac_calcinosis0.76620038
93MP0005410_abnormal_fertilization0.76029372
94MP0001853_heart_inflammation0.75793169
95MP0001529_abnormal_vocalization0.74840006
96MP0001845_abnormal_inflammatory_respons0.74785591
97MP0003693_abnormal_embryo_hatching0.74235700
98MP0003880_abnormal_central_pattern0.72243182
99MP0003638_abnormal_response/metabolism_0.72028279
100MP0002735_abnormal_chemical_nociception0.71423831

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.78365280
23-Methylglutaconic aciduria (HP:0003535)4.56946939
3Mitochondrial inheritance (HP:0001427)4.36412095
4Abnormal mitochondria in muscle tissue (HP:0008316)4.26769170
5Reticulocytopenia (HP:0001896)4.14367468
6Acute encephalopathy (HP:0006846)4.08893243
7Progressive macrocephaly (HP:0004481)3.94395996
8Increased CSF lactate (HP:0002490)3.88185282
9Abnormality of cells of the erythroid lineage (HP:0012130)3.79581023
10Hepatocellular necrosis (HP:0001404)3.77193532
11Increased hepatocellular lipid droplets (HP:0006565)3.75783222
12Lipid accumulation in hepatocytes (HP:0006561)3.65689242
13Macrocytic anemia (HP:0001972)3.56869807
14Hepatic necrosis (HP:0002605)3.46613995
15Pancreatic cysts (HP:0001737)3.44222724
16Cerebral edema (HP:0002181)3.40239302
17Stomatitis (HP:0010280)3.30149347
18Abnormal number of erythroid precursors (HP:0012131)3.29464181
19Increased IgM level (HP:0003496)3.14424142
20IgG deficiency (HP:0004315)3.12384980
21Renal Fanconi syndrome (HP:0001994)3.11232513
22True hermaphroditism (HP:0010459)3.10728160
23Elevated erythrocyte sedimentation rate (HP:0003565)3.10482723
24Congenital stationary night blindness (HP:0007642)3.09631596
25Optic disc pallor (HP:0000543)3.04524434
26Pancreatic fibrosis (HP:0100732)2.97771643
27Aplastic anemia (HP:0001915)2.97743860
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.97722499
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.88959616
30Increased intramyocellular lipid droplets (HP:0012240)2.85200292
31Abnormality of midbrain morphology (HP:0002418)2.84213356
32Molar tooth sign on MRI (HP:0002419)2.84213356
33Exertional dyspnea (HP:0002875)2.78671083
34Colon cancer (HP:0003003)2.72407916
35Increased muscle lipid content (HP:0009058)2.61748933
36Lactic acidosis (HP:0003128)2.60092093
37Increased serum lactate (HP:0002151)2.53453613
38Glycosuria (HP:0003076)2.52983283
39Abnormality of urine glucose concentration (HP:0011016)2.52983283
40Abolished electroretinogram (ERG) (HP:0000550)2.52257630
41Nephronophthisis (HP:0000090)2.48802392
42Pallor (HP:0000980)2.46157618
43Lethargy (HP:0001254)2.45387512
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43609864
45Respiratory failure (HP:0002878)2.37815896
46Septo-optic dysplasia (HP:0100842)2.35115558
47Abnormal rod and cone electroretinograms (HP:0008323)2.32433585
48Abnormal ciliary motility (HP:0012262)2.28708359
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25166145
50Hyperglycinemia (HP:0002154)2.23723311
51Abnormality of the renal cortex (HP:0011035)2.21131849
52Respiratory difficulties (HP:0002880)2.20387482
53Medial flaring of the eyebrow (HP:0010747)2.19979482
54Congenital, generalized hypertrichosis (HP:0004540)2.19647895
55Abnormal respiratory motile cilium physiology (HP:0012261)2.18439061
56Exercise intolerance (HP:0003546)2.17424334
57Sclerocornea (HP:0000647)2.14808182
58Partial duplication of thumb phalanx (HP:0009944)2.14165696
59Dicarboxylic aciduria (HP:0003215)2.13250348
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13250348
61Stenosis of the external auditory canal (HP:0000402)2.12519623
62Attenuation of retinal blood vessels (HP:0007843)2.12303704
63Absent thumb (HP:0009777)2.11390213
64Absent/shortened dynein arms (HP:0200106)2.09126722
65Dynein arm defect of respiratory motile cilia (HP:0012255)2.09126722
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08591956
67Decreased central vision (HP:0007663)2.08310325
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07583083
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07583083
70Cystic liver disease (HP:0006706)2.07076596
71Hyperphosphaturia (HP:0003109)2.05293965
72Abnormality of renal resorption (HP:0011038)2.02384501
73Abnormality of the renal medulla (HP:0100957)2.01952465
74Abnormal biliary tract physiology (HP:0012439)1.98787275
75Bile duct proliferation (HP:0001408)1.98787275
76Methylmalonic aciduria (HP:0012120)1.95901556
77Aplasia/hypoplasia of the uterus (HP:0008684)1.94823511
78Pancytopenia (HP:0001876)1.92329626
79Hypoplasia of the radius (HP:0002984)1.92071183
80Abnormal delayed hypersensitivity skin test (HP:0002963)1.91810898
81Abnormal respiratory motile cilium morphology (HP:0005938)1.91533907
82Abnormal respiratory epithelium morphology (HP:0012253)1.91533907
83Type 2 muscle fiber atrophy (HP:0003554)1.90980145
84Leukodystrophy (HP:0002415)1.90526344
85Postaxial foot polydactyly (HP:0001830)1.89973673
86Confusion (HP:0001289)1.88659863
87Panhypogammaglobulinemia (HP:0003139)1.88256568
88Male pseudohermaphroditism (HP:0000037)1.86503392
89Abnormality of T cells (HP:0002843)1.86092833
90Partial duplication of the phalanx of hand (HP:0009999)1.85499009
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.84304009
92Abnormality of B cell number (HP:0010975)1.83564695
93Hyperglycinuria (HP:0003108)1.83252921
94Pendular nystagmus (HP:0012043)1.82462704
95Abnormality of T cell physiology (HP:0011840)1.79416478
96Renal cortical cysts (HP:0000803)1.78868031
97Constricted visual fields (HP:0001133)1.78439505
98Generalized aminoaciduria (HP:0002909)1.76945710
99Severe combined immunodeficiency (HP:0004430)1.75554920
100Methylmalonic acidemia (HP:0002912)1.74657381

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.73094264
2TXK3.35031232
3CDK193.03651850
4TAOK33.00959775
5TLK12.90232309
6KDR2.63048495
7ZAK2.54662386
8ADRBK22.48818608
9WNK42.43811771
10PASK2.41811662
11NUAK12.27449336
12GRK12.26496022
13BCKDK2.22455841
14NME12.17315776
15PINK11.80971809
16TEC1.78122465
17NME21.76787729
18FRK1.73841904
19VRK11.71870844
20PBK1.70264678
21TIE11.70149660
22BMPR1B1.68652552
23MAP4K21.63689328
24MAP4K11.56518800
25DYRK21.48891160
26STK161.41918343
27TESK21.40417073
28MAP3K121.34092834
29KIT1.31743201
30MUSK1.23857669
31WNK31.22539850
32INSRR1.21080652
33ACVR1B1.18856600
34MAPKAPK51.18287774
35ITK1.16992590
36STK391.10787773
37TAF11.04957012
38ADRBK11.03135168
39FES0.97768900
40MST40.97519313
41IKBKB0.94530478
42LRRK20.92838186
43EIF2AK10.92315530
44SCYL20.92228610
45OXSR10.89092509
46PRKCQ0.85121565
47PIK3CG0.83529544
48GRK60.82188663
49SYK0.82160127
50DAPK30.82128924
51MAP3K110.80768533
52LIMK10.78915274
53DAPK10.78162054
54DAPK20.73707903
55RPS6KB20.73055623
56PLK40.71292138
57EIF2AK30.70442543
58BTK0.65458733
59LCK0.65338627
60RPS6KA50.64895864
61PRKCG0.64754737
62OBSCN0.64424542
63CDC70.63257204
64MYLK0.60584327
65IKBKE0.59518502
66GRK50.59130711
67CSNK2A20.58723392
68CAMKK10.57548761
69NEK10.56592429
70PIK3CA0.51185656
71TGFBR10.49976077
72PRKCA0.48905716
73TSSK60.48620291
74BUB10.48248354
75TYK20.48046560
76WNK10.47101246
77CSNK2A10.46619920
78PRKACA0.46423234
79MAPKAPK30.46290001
80ABL20.45836706
81LYN0.45109380
82MAP2K60.44822367
83CAMK10.44584527
84PLK30.44276884
85AURKB0.43916780
86JAK30.43636269
87ATR0.43588594
88CAMKK20.42395677
89CSK0.41639783
90TNIK0.40826599
91PRKCD0.40739632
92PRKCH0.40082326
93MAPK150.40023613
94PRKCE0.39838043
95ILK0.38328748
96PLK20.35798415
97SRPK10.34860861
98MATK0.34272235
99IGF1R0.32699878
100PIM10.32074985

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.58500423
2Oxidative phosphorylation_Homo sapiens_hsa001904.10518028
3Parkinsons disease_Homo sapiens_hsa050123.47301597
4Proteasome_Homo sapiens_hsa030503.22857723
5Primary immunodeficiency_Homo sapiens_hsa053402.77718546
6Asthma_Homo sapiens_hsa053102.36054361
7Huntingtons disease_Homo sapiens_hsa050162.31054213
8Alzheimers disease_Homo sapiens_hsa050102.25649192
9RNA polymerase_Homo sapiens_hsa030202.21765087
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08530780
11Protein export_Homo sapiens_hsa030602.05465707
12Allograft rejection_Homo sapiens_hsa053302.02149645
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.01124964
14Cardiac muscle contraction_Homo sapiens_hsa042601.96881610
15Autoimmune thyroid disease_Homo sapiens_hsa053201.96752231
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82922802
17Linoleic acid metabolism_Homo sapiens_hsa005911.77229325
18Homologous recombination_Homo sapiens_hsa034401.57897190
19Phototransduction_Homo sapiens_hsa047441.57098454
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48983827
21Graft-versus-host disease_Homo sapiens_hsa053321.43375725
22Fat digestion and absorption_Homo sapiens_hsa049751.35168966
23RNA degradation_Homo sapiens_hsa030181.33947918
24Antigen processing and presentation_Homo sapiens_hsa046121.33821775
25Caffeine metabolism_Homo sapiens_hsa002321.31024747
26Pyrimidine metabolism_Homo sapiens_hsa002401.30722956
27Type I diabetes mellitus_Homo sapiens_hsa049401.30067313
28DNA replication_Homo sapiens_hsa030301.29891629
29Retinol metabolism_Homo sapiens_hsa008301.28714751
30Chemical carcinogenesis_Homo sapiens_hsa052041.27944691
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26412358
32Nucleotide excision repair_Homo sapiens_hsa034201.26146592
33Peroxisome_Homo sapiens_hsa041461.25026479
34Mismatch repair_Homo sapiens_hsa034301.23542218
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18828238
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15703731
37Arachidonic acid metabolism_Homo sapiens_hsa005901.10703204
38Propanoate metabolism_Homo sapiens_hsa006401.07605343
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06797308
40Butanoate metabolism_Homo sapiens_hsa006501.02794107
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02374414
42Base excision repair_Homo sapiens_hsa034101.01815699
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01210543
44One carbon pool by folate_Homo sapiens_hsa006701.00953467
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97704150
46Ether lipid metabolism_Homo sapiens_hsa005650.97248326
47Nitrogen metabolism_Homo sapiens_hsa009100.96583778
48Hematopoietic cell lineage_Homo sapiens_hsa046400.95883024
49Purine metabolism_Homo sapiens_hsa002300.95517170
50Fanconi anemia pathway_Homo sapiens_hsa034600.93250144
51Tryptophan metabolism_Homo sapiens_hsa003800.88951486
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88728126
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88233393
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87479231
55Spliceosome_Homo sapiens_hsa030400.85495241
56Vitamin digestion and absorption_Homo sapiens_hsa049770.83782991
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.83726105
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80632772
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79654878
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.77663705
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.77473277
62Basal transcription factors_Homo sapiens_hsa030220.77110719
63Glutathione metabolism_Homo sapiens_hsa004800.71196013
64Rheumatoid arthritis_Homo sapiens_hsa053230.71067888
65Metabolic pathways_Homo sapiens_hsa011000.70258151
66Folate biosynthesis_Homo sapiens_hsa007900.69735966
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.64579534
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64162018
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61921787
70Fatty acid elongation_Homo sapiens_hsa000620.61429585
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.60487920
72Mineral absorption_Homo sapiens_hsa049780.59703209
73RNA transport_Homo sapiens_hsa030130.58397596
74Fatty acid degradation_Homo sapiens_hsa000710.58156636
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56897045
76Olfactory transduction_Homo sapiens_hsa047400.51648279
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.48961933
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47089721
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46466457
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46055161
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44491496
82Glycerolipid metabolism_Homo sapiens_hsa005610.44203062
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43640138
84Collecting duct acid secretion_Homo sapiens_hsa049660.38394852
85T cell receptor signaling pathway_Homo sapiens_hsa046600.37771912
86Pyruvate metabolism_Homo sapiens_hsa006200.36391252
87Arginine and proline metabolism_Homo sapiens_hsa003300.35515227
88Taste transduction_Homo sapiens_hsa047420.34826801
89Systemic lupus erythematosus_Homo sapiens_hsa053220.33843306
90beta-Alanine metabolism_Homo sapiens_hsa004100.33174143
91Sulfur metabolism_Homo sapiens_hsa009200.29318089
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25260851
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.25109213
94Arginine biosynthesis_Homo sapiens_hsa002200.22365289
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20236353
96Regulation of autophagy_Homo sapiens_hsa041400.17009018
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16595097
98Protein digestion and absorption_Homo sapiens_hsa049740.15756042
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14205944
100Viral myocarditis_Homo sapiens_hsa054160.11928779

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