RPL12P13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.08018861
2ribosomal small subunit biogenesis (GO:0042274)8.96250152
3translational termination (GO:0006415)8.72840029
4ribosomal small subunit assembly (GO:0000028)8.51765436
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.29065485
6protein targeting to ER (GO:0045047)7.24638950
7cotranslational protein targeting to membrane (GO:0006613)7.19868052
8maturation of SSU-rRNA (GO:0030490)7.13508348
9translational elongation (GO:0006414)7.07675275
10establishment of protein localization to endoplasmic reticulum (GO:0072599)7.02437513
11protein localization to endoplasmic reticulum (GO:0070972)6.76026491
12cellular protein complex disassembly (GO:0043624)6.68481989
13viral life cycle (GO:0019058)6.54065864
14behavioral response to nicotine (GO:0035095)6.21156309
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.19973268
16ribosomal large subunit biogenesis (GO:0042273)5.76439708
17protein complex disassembly (GO:0043241)5.58835301
18translational initiation (GO:0006413)5.55658417
19nonmotile primary cilium assembly (GO:0035058)5.38688651
20macromolecular complex disassembly (GO:0032984)5.21747291
21ATP synthesis coupled proton transport (GO:0015986)4.93098691
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.93098691
23protein targeting to membrane (GO:0006612)4.91233580
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.64549002
25translation (GO:0006412)4.57857001
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.48151393
27nuclear-transcribed mRNA catabolic process (GO:0000956)4.38311987
28embryonic body morphogenesis (GO:0010172)4.28193054
29respiratory tube development (GO:0030323)4.18720096
30mRNA catabolic process (GO:0006402)4.17869854
31pyrimidine nucleobase catabolic process (GO:0006208)4.06525216
32kidney morphogenesis (GO:0060993)4.05573679
33ribonucleoprotein complex biogenesis (GO:0022613)4.05085904
34lens fiber cell development (GO:0070307)4.04831386
35chaperone-mediated protein transport (GO:0072321)4.00754375
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.90081440
37NADH dehydrogenase complex assembly (GO:0010257)3.90081440
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.90081440
39water-soluble vitamin biosynthetic process (GO:0042364)3.89644930
40body morphogenesis (GO:0010171)3.88840972
41lung epithelium development (GO:0060428)3.86578837
42metanephric nephron tubule development (GO:0072234)3.79801878
43metanephric tubule development (GO:0072170)3.79801878
44RNA catabolic process (GO:0006401)3.72772601
45cellular component biogenesis (GO:0044085)3.71599877
46negative regulation of mast cell activation (GO:0033004)3.64506982
47protein neddylation (GO:0045116)3.59114048
48positive regulation of respiratory burst (GO:0060267)3.54063076
49peptidyl-histidine modification (GO:0018202)3.52189089
50protein complex biogenesis (GO:0070271)3.50242308
51axoneme assembly (GO:0035082)3.48570239
52collecting duct development (GO:0072044)3.46910788
53lung-associated mesenchyme development (GO:0060484)3.41671178
54nucleobase catabolic process (GO:0046113)3.35350329
55establishment of protein localization to membrane (GO:0090150)3.31153445
56metanephric nephron epithelium development (GO:0072243)3.25949385
57protein targeting (GO:0006605)3.23541956
58mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.22774028
59positive regulation of organelle assembly (GO:1902117)3.21994748
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21957304
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21957304
62mitochondrial respiratory chain complex assembly (GO:0033108)3.17471458
63rRNA processing (GO:0006364)3.15798118
64substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.15636705
65substrate-independent telencephalic tangential migration (GO:0021826)3.15636705
66activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.15521341
67respiratory electron transport chain (GO:0022904)3.15209423
68electron transport chain (GO:0022900)3.13205438
69rRNA metabolic process (GO:0016072)3.08130990
70negative regulation of T cell differentiation in thymus (GO:0033085)3.06755105
71establishment of protein localization to mitochondrial membrane (GO:0090151)3.05404464
72establishment of protein localization to organelle (GO:0072594)3.05366103
73metanephric epithelium development (GO:0072207)3.02641708
74aldehyde catabolic process (GO:0046185)3.01152199
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98163918
76axon ensheathment in central nervous system (GO:0032291)2.97466055
77central nervous system myelination (GO:0022010)2.97466055
78termination of RNA polymerase III transcription (GO:0006386)2.95077667
79transcription elongation from RNA polymerase III promoter (GO:0006385)2.95077667
80lung morphogenesis (GO:0060425)2.94946043
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94295012
82negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.93590630
83ATP biosynthetic process (GO:0006754)2.93334594
84purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.90454324
85cartilage morphogenesis (GO:0060536)2.86278658
86purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85126348
87GTP biosynthetic process (GO:0006183)2.81333468
88cilium movement (GO:0003341)2.76716244
89cellular response to dexamethasone stimulus (GO:0071549)2.75663715
90positive regulation of muscle cell apoptotic process (GO:0010661)2.69962800
91response to redox state (GO:0051775)2.67231115
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.65954135
93synaptic transmission, cholinergic (GO:0007271)2.63797960
94establishment of planar polarity (GO:0001736)2.63700844
95establishment of tissue polarity (GO:0007164)2.63700844
96regulation of mesoderm development (GO:2000380)2.63190519
97positive regulation of meiosis (GO:0045836)2.58301654
98ribonucleoside triphosphate biosynthetic process (GO:0009201)2.56980588
99response to dexamethasone (GO:0071548)2.53412692
100DNA deamination (GO:0045006)2.52024936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.56002760
2EZH2_22144423_ChIP-Seq_EOC_Human5.21525489
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.58873226
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.27665848
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.05513664
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71763117
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68772885
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67694962
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.57524756
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54383536
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.43556988
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37949339
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32751020
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.31255904
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.22153474
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21109579
17ZNF274_21170338_ChIP-Seq_K562_Hela2.18960435
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92652698
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89480823
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.84720138
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84316030
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.83941459
23XRN2_22483619_ChIP-Seq_HELA_Human1.68225686
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61208934
25TTF2_22483619_ChIP-Seq_HELA_Human1.58501119
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.58089801
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56240031
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54308412
29MYC_18940864_ChIP-ChIP_HL60_Human1.53088554
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53063171
31VDR_22108803_ChIP-Seq_LS180_Human1.52799255
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52777514
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47192236
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46664013
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45127019
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45061173
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43735803
38VDR_23849224_ChIP-Seq_CD4+_Human1.42142970
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41773116
40FOXP3_21729870_ChIP-Seq_TREG_Human1.37964488
41TAF2_19829295_ChIP-Seq_ESCs_Human1.34897775
42IGF1R_20145208_ChIP-Seq_DFB_Human1.34362236
43ERA_21632823_ChIP-Seq_H3396_Human1.34340892
44TDRD3_21172665_ChIP-Seq_MCF-7_Human1.33992486
45SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33960547
46MYC_19829295_ChIP-Seq_ESCs_Human1.33200991
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.32976348
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.32733985
49ELK1_19687146_ChIP-ChIP_HELA_Human1.32689030
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.29997268
51KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27617625
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27503151
53REST_21632747_ChIP-Seq_MESCs_Mouse1.27275284
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25416592
55RNF2_27304074_Chip-Seq_NSC_Mouse1.24806401
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23725378
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22929732
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19861858
59IRF1_19129219_ChIP-ChIP_H3396_Human1.17813295
60EWS_26573619_Chip-Seq_HEK293_Human1.16967405
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.16090610
62NCOR_22424771_ChIP-Seq_293T_Human1.13610238
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13138813
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13138813
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10374596
66FUS_26573619_Chip-Seq_HEK293_Human1.08734794
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08393385
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07343425
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06923645
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.06447096
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04402531
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03470506
73LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03154607
74BCL6_27268052_Chip-Seq_Bcells_Human1.02391925
75TAF15_26573619_Chip-Seq_HEK293_Human1.01407135
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.00562627
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00322963
78TP53_22573176_ChIP-Seq_HFKS_Human1.00084720
79GABP_19822575_ChIP-Seq_HepG2_Human0.99563470
80ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99377082
81FOXP1_21924763_ChIP-Seq_HESCs_Human0.99007485
82SRF_21415370_ChIP-Seq_HL-1_Mouse0.98751523
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.97320312
84FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97320312
85GATA3_21867929_ChIP-Seq_TH1_Mouse0.96717052
86FLI1_27457419_Chip-Seq_LIVER_Mouse0.96379065
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96269164
88FOXH1_21741376_ChIP-Seq_ESCs_Human0.95666206
89NANOG_20526341_ChIP-Seq_ESCs_Human0.94898704
90CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94796687
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94100554
92CTCF_27219007_Chip-Seq_Bcells_Human0.93117165
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92394963
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.91996793
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91786980
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91299417
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91063111
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90653439
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90476060
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.90087401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.52789792
2MP0006292_abnormal_olfactory_placode4.67934095
3MP0008789_abnormal_olfactory_epithelium4.21823320
4MP0010030_abnormal_orbit_morphology3.61440594
5MP0005499_abnormal_olfactory_system3.40238972
6MP0005394_taste/olfaction_phenotype3.40238972
7MP0002163_abnormal_gland_morphology2.88365163
8MP0005646_abnormal_pituitary_gland2.82004841
9MP0003646_muscle_fatigue2.51712496
10MP0001293_anophthalmia2.37678864
11MP0001346_abnormal_lacrimal_gland2.31215489
12MP0002102_abnormal_ear_morphology2.26716849
13MP0002653_abnormal_ependyma_morphology2.19375210
14MP0002837_dystrophic_cardiac_calcinosis2.07363879
15MP0005379_endocrine/exocrine_gland_phen1.87686854
16MP0008877_abnormal_DNA_methylation1.79035252
17MP0004885_abnormal_endolymph1.76680345
18MP0002938_white_spotting1.74581327
19MP0010386_abnormal_urinary_bladder1.72404708
20MP0003878_abnormal_ear_physiology1.64686393
21MP0005377_hearing/vestibular/ear_phenot1.64686393
22MP0006072_abnormal_retinal_apoptosis1.63009607
23MP0001348_abnormal_lacrimal_gland1.48340059
24MP0003693_abnormal_embryo_hatching1.48141799
25MP0005174_abnormal_tail_pigmentation1.47603814
26MP0004142_abnormal_muscle_tone1.41472669
27MP0003283_abnormal_digestive_organ1.40036601
28MP0003787_abnormal_imprinting1.39416081
29MP0005248_abnormal_Harderian_gland1.35630064
30MP0002233_abnormal_nose_morphology1.30810721
31MP0005360_urolithiasis1.28296153
32MP0001485_abnormal_pinna_reflex1.25654683
33MP0009745_abnormal_behavioral_response1.23193832
34MP0005551_abnormal_eye_electrophysiolog1.23048654
35MP0002095_abnormal_skin_pigmentation1.20949534
36MP0001968_abnormal_touch/_nociception1.19441735
37MP0000631_abnormal_neuroendocrine_gland1.19285890
38MP0000049_abnormal_middle_ear1.18136667
39MP0004742_abnormal_vestibular_system1.18053304
40MP0002272_abnormal_nervous_system1.16321385
41MP0005389_reproductive_system_phenotype1.15154259
42MP0008872_abnormal_physiological_respon1.13448448
43MP0003123_paternal_imprinting1.11148052
44MP0002160_abnormal_reproductive_system1.10723089
45MP0000778_abnormal_nervous_system1.10628301
46MP0001324_abnormal_eye_pigmentation1.09271978
47MP0003937_abnormal_limbs/digits/tail_de1.08611473
48MP0002876_abnormal_thyroid_physiology1.08441546
49MP0005195_abnormal_posterior_eye1.08118178
50MP0005084_abnormal_gallbladder_morpholo1.03725955
51MP0002736_abnormal_nociception_after1.03344108
52MP0006036_abnormal_mitochondrial_physio1.03126493
53MP0001919_abnormal_reproductive_system1.01197160
54MP0000026_abnormal_inner_ear1.00508761
55MP0003136_yellow_coat_color0.99211309
56MP0005391_vision/eye_phenotype0.98636958
57MP0003786_premature_aging0.93875875
58MP0002234_abnormal_pharynx_morphology0.92338220
59MP0003119_abnormal_digestive_system0.92191119
60MP0001970_abnormal_pain_threshold0.91868837
61MP0002210_abnormal_sex_determination0.91531203
62MP0002733_abnormal_thermal_nociception0.89897124
63MP0008775_abnormal_heart_ventricle0.89534414
64MP0002092_abnormal_eye_morphology0.89228867
65MP0002638_abnormal_pupillary_reflex0.89187631
66MP0003011_delayed_dark_adaptation0.89140168
67MP0005645_abnormal_hypothalamus_physiol0.89044078
68MP0003567_abnormal_fetal_cardiomyocyte0.83892213
69MP0008875_abnormal_xenobiotic_pharmacok0.83772892
70MP0004133_heterotaxia0.82798606
71MP0001905_abnormal_dopamine_level0.82617914
72MP0003936_abnormal_reproductive_system0.81139467
73MP0002752_abnormal_somatic_nervous0.80584872
74MP0003938_abnormal_ear_development0.80165645
75MP0002064_seizures0.79640285
76MP0001765_abnormal_ion_homeostasis0.77637798
77MP0001986_abnormal_taste_sensitivity0.77033181
78MP0005253_abnormal_eye_physiology0.74126211
79MP0000685_abnormal_immune_system0.73376254
80MP0006276_abnormal_autonomic_nervous0.72960581
81MP0001963_abnormal_hearing_physiology0.72279234
82MP0003763_abnormal_thymus_physiology0.69674697
83MP0001486_abnormal_startle_reflex0.69587097
84MP0004145_abnormal_muscle_electrophysio0.69566863
85MP0000955_abnormal_spinal_cord0.69405389
86MP0000538_abnormal_urinary_bladder0.69140545
87MP0002557_abnormal_social/conspecific_i0.67620116
88MP0009046_muscle_twitch0.67112284
89MP0001286_abnormal_eye_development0.66506762
90MP0009053_abnormal_anal_canal0.65935496
91MP0001663_abnormal_digestive_system0.65898416
92MP0001145_abnormal_male_reproductive0.65844054
93MP0002184_abnormal_innervation0.65503395
94MP0000653_abnormal_sex_gland0.65363712
95MP0001929_abnormal_gametogenesis0.64090437
96MP0002697_abnormal_eye_size0.64011450
97MP0003879_abnormal_hair_cell0.63835847
98MP0002735_abnormal_chemical_nociception0.63318812
99MP0008995_early_reproductive_senescence0.62857568
100MP0002063_abnormal_learning/memory/cond0.60333645

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the sacrum (HP:0008517)6.95958785
2Reticulocytopenia (HP:0001896)5.14689057
3Abnormality of cells of the erythroid lineage (HP:0012130)4.82658749
4Abnormal ciliary motility (HP:0012262)4.54389448
5Macrocytic anemia (HP:0001972)4.31389580
6Abnormal respiratory motile cilium morphology (HP:0005938)4.25227687
7Abnormal respiratory epithelium morphology (HP:0012253)4.25227687
8Increased intramyocellular lipid droplets (HP:0012240)4.23886974
9Increased hepatocellular lipid droplets (HP:0006565)4.22828688
103-Methylglutaconic aciduria (HP:0003535)4.09467874
11Abnormal number of erythroid precursors (HP:0012131)4.03833879
12Lipid accumulation in hepatocytes (HP:0006561)3.90334616
13Increased muscle lipid content (HP:0009058)3.70716765
14Pancreatic cysts (HP:0001737)3.64687057
15Nephronophthisis (HP:0000090)3.63595329
16Acute necrotizing encephalopathy (HP:0006965)3.61314669
17Maternal diabetes (HP:0009800)3.56032463
18Pallor (HP:0000980)3.53554960
19Abnormal respiratory motile cilium physiology (HP:0012261)3.44680917
20Renal Fanconi syndrome (HP:0001994)3.39159000
21Stomatitis (HP:0010280)3.37891948
22Abnormality of midbrain morphology (HP:0002418)3.36168589
23Molar tooth sign on MRI (HP:0002419)3.36168589
24Mitochondrial inheritance (HP:0001427)3.28844852
25Increased CSF lactate (HP:0002490)3.20131163
26Abnormal mitochondria in muscle tissue (HP:0008316)3.12924482
27Abnormal pupillary function (HP:0007686)3.11066249
28Acute encephalopathy (HP:0006846)3.08080214
29Tubular atrophy (HP:0000092)3.05674334
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.00602802
31Abnormality of the renal cortex (HP:0011035)2.95501564
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.92592779
33Abnormality of the renal medulla (HP:0100957)2.92264669
34Pancreatic fibrosis (HP:0100732)2.90422022
35Anencephaly (HP:0002323)2.88544754
36Chronic sinusitis (HP:0011109)2.87990562
37Progressive macrocephaly (HP:0004481)2.85633166
38Asplenia (HP:0001746)2.71190899
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70384807
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70384807
41Aplasia/Hypoplasia of the spleen (HP:0010451)2.69372561
42Exertional dyspnea (HP:0002875)2.66206692
43True hermaphroditism (HP:0010459)2.62372322
44Rhinitis (HP:0012384)2.61447737
45Exercise intolerance (HP:0003546)2.57778722
46Rib fusion (HP:0000902)2.53490622
47Hyperglycinemia (HP:0002154)2.49748314
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.45461086
49Abnormality of renal resorption (HP:0011038)2.34377859
50Decreased central vision (HP:0007663)2.30152807
51Absent thumb (HP:0009777)2.29474537
52Colon cancer (HP:0003003)2.26345597
53Anophthalmia (HP:0000528)2.26273910
54Depressed nasal ridge (HP:0000457)2.26139726
55Increased serum lactate (HP:0002151)2.25511114
56Pendular nystagmus (HP:0012043)2.18817890
57Horseshoe kidney (HP:0000085)2.18677894
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.18134723
59Absent/shortened dynein arms (HP:0200106)2.18134723
60Rectal prolapse (HP:0002035)2.17621682
61Severe visual impairment (HP:0001141)2.17580192
62Respiratory difficulties (HP:0002880)2.16169539
63Septo-optic dysplasia (HP:0100842)2.15131495
64Myokymia (HP:0002411)2.12608885
65Sclerocornea (HP:0000647)2.09464962
66Concave nail (HP:0001598)2.08561694
67Chronic hepatic failure (HP:0100626)2.07645218
68Cerebral edema (HP:0002181)2.05879641
69Hyperphosphaturia (HP:0003109)2.05515829
70Type II lissencephaly (HP:0007260)2.04470353
71Abnormal rod and cone electroretinograms (HP:0008323)2.04275151
72Dyschromatopsia (HP:0007641)2.03976991
73Myelomeningocele (HP:0002475)2.02463378
74Hypoplasia of the radius (HP:0002984)2.01536327
75Optic nerve coloboma (HP:0000588)1.99281718
76Agitation (HP:0000713)1.98647526
77Holoprosencephaly (HP:0001360)1.95314557
78Glycosuria (HP:0003076)1.93583364
79Abnormality of urine glucose concentration (HP:0011016)1.93583364
80Lactic acidosis (HP:0003128)1.93058827
81Abnormality of the phalanges of the 5th finger (HP:0004213)1.92046494
82Congenital stationary night blindness (HP:0007642)1.91442127
83Ectopic kidney (HP:0000086)1.90653434
84Congenital, generalized hypertrichosis (HP:0004540)1.84232384
85Methylmalonic acidemia (HP:0002912)1.83514525
86Triphalangeal thumb (HP:0001199)1.83005053
87Abolished electroretinogram (ERG) (HP:0000550)1.82479665
88Hepatocellular necrosis (HP:0001404)1.81224355
89Medial flaring of the eyebrow (HP:0010747)1.81034369
90Hepatic necrosis (HP:0002605)1.78438221
91Cystic liver disease (HP:0006706)1.78150169
92Optic disc pallor (HP:0000543)1.76388838
93Severe muscular hypotonia (HP:0006829)1.76149539
94Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.76080958
95Meningocele (HP:0002435)1.73060010
96Postaxial foot polydactyly (HP:0001830)1.72184709
97Symphalangism affecting the phalanges of the hand (HP:0009773)1.69465606
98Abnormal urine phosphate concentration (HP:0012599)1.69179782
99Forearm undergrowth (HP:0009821)1.67100685
100Methylmalonic aciduria (HP:0012120)1.66262279

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K23.68627235
2WNK43.38522119
3LIMK13.05930280
4EIF2AK12.83234146
5TLK12.79983309
6ADRBK22.58046235
7BUB12.34308178
8NME22.30107004
9GRK12.28240347
10DYRK22.23931212
11CDK82.16470407
12CAMKK22.09688192
13ZAK2.09142419
14TNK22.06306077
15CDC71.99003093
16TIE11.82503288
17MAP3K41.80001160
18NEK91.74217099
19BCKDK1.59532609
20STK391.55531570
21MKNK21.48071613
22LRRK21.40462187
23PIK3CA1.35494044
24TXK1.35491807
25CAMKK11.34494976
26PINK11.33757002
27MAP2K11.30922986
28WNK31.28121556
29BMPR1B1.27278282
30WNK11.24484351
31BRSK11.24418798
32PLK41.20286174
33STK161.18851135
34EPHB21.18460138
35DYRK1A1.13447844
36NUAK11.03369502
37FRK1.02277251
38CDC42BPA1.02190597
39PRKCQ0.94453781
40PDK20.92947522
41TNIK0.86957463
42CAMK10.86788480
43TEC0.85992475
44AURKA0.85116856
45TESK20.83777012
46NME10.83693873
47ADRBK10.83213284
48CSNK2A20.81766635
49STK110.79652824
50RPS6KA60.78238251
51INSRR0.78184039
52AURKB0.76829959
53CASK0.73918220
54DAPK30.73816687
55BTK0.73251737
56CSNK2A10.73046627
57PRKCG0.72152320
58DYRK1B0.69998893
59VRK20.68856973
60PAK30.68283464
61OXSR10.65549121
62PRKD30.64417539
63PRKACA0.64186232
64CAMK1D0.63323204
65CDK190.62340955
66VRK10.61778742
67MARK30.61053125
68PLK10.59541444
69RPS6KA50.57451482
70PRKCZ0.56464911
71PHKG20.56345544
72PHKG10.56345544
73GRK60.54582191
74OBSCN0.54043103
75STK38L0.53684207
76ATR0.49849255
77MAP2K70.49834911
78BRSK20.47172724
79MAP4K20.46506964
80MAPK150.46421935
81RPS6KC10.46184090
82RPS6KL10.46184090
83ILK0.45815038
84TGFBR10.45342394
85MAP3K110.45287971
86SRPK10.44126357
87PRKCA0.43845130
88PRKCH0.43361746
89MAP4K10.42885571
90PRKD20.42829673
91PKN20.41978588
92ITK0.40535173
93EPHA40.39580416
94PRKCI0.38710737
95CAMK2A0.38570475
96GRK50.38417939
97MAP2K60.36939178
98CSNK1E0.36526176
99TAOK30.36388638
100MINK10.36086258

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030108.13127619
2Oxidative phosphorylation_Homo sapiens_hsa001903.62030272
3Parkinsons disease_Homo sapiens_hsa050123.29019601
4Asthma_Homo sapiens_hsa053102.91961343
5RNA polymerase_Homo sapiens_hsa030202.39908928
6Huntingtons disease_Homo sapiens_hsa050162.29016137
7Cardiac muscle contraction_Homo sapiens_hsa042602.17640203
8Allograft rejection_Homo sapiens_hsa053302.13084803
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.11709938
10Alzheimers disease_Homo sapiens_hsa050102.08885214
11Autoimmune thyroid disease_Homo sapiens_hsa053202.05509695
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93351407
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92807877
14Mismatch repair_Homo sapiens_hsa034301.91391946
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88775407
16Type I diabetes mellitus_Homo sapiens_hsa049401.71355270
17Graft-versus-host disease_Homo sapiens_hsa053321.63967254
18Homologous recombination_Homo sapiens_hsa034401.59246118
19Protein export_Homo sapiens_hsa030601.55781258
20RNA degradation_Homo sapiens_hsa030181.53417472
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47692935
22DNA replication_Homo sapiens_hsa030301.44509954
23Linoleic acid metabolism_Homo sapiens_hsa005911.41653564
24Sulfur relay system_Homo sapiens_hsa041221.32824601
25Pyrimidine metabolism_Homo sapiens_hsa002401.31171734
26Proteasome_Homo sapiens_hsa030501.29919824
27Nucleotide excision repair_Homo sapiens_hsa034201.13299773
28Viral myocarditis_Homo sapiens_hsa054161.11994063
29Fanconi anemia pathway_Homo sapiens_hsa034601.10796473
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08947057
31Basal transcription factors_Homo sapiens_hsa030221.08207463
32Primary immunodeficiency_Homo sapiens_hsa053401.06969412
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06431390
34Arachidonic acid metabolism_Homo sapiens_hsa005901.05158572
35Hedgehog signaling pathway_Homo sapiens_hsa043401.02178780
36Basal cell carcinoma_Homo sapiens_hsa052171.00975189
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.00599961
38Tryptophan metabolism_Homo sapiens_hsa003801.00098571
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98898667
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98441881
41One carbon pool by folate_Homo sapiens_hsa006700.95028350
42Phototransduction_Homo sapiens_hsa047440.92972902
43Base excision repair_Homo sapiens_hsa034100.87445558
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87005232
45beta-Alanine metabolism_Homo sapiens_hsa004100.85274775
46Purine metabolism_Homo sapiens_hsa002300.82328885
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79596482
48Regulation of autophagy_Homo sapiens_hsa041400.78885486
49Propanoate metabolism_Homo sapiens_hsa006400.76998713
50Folate biosynthesis_Homo sapiens_hsa007900.76847680
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72361053
52Rheumatoid arthritis_Homo sapiens_hsa053230.68817582
53Ovarian steroidogenesis_Homo sapiens_hsa049130.67823915
54Nicotine addiction_Homo sapiens_hsa050330.67644232
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64800233
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63419969
57Insulin secretion_Homo sapiens_hsa049110.62431153
58Butanoate metabolism_Homo sapiens_hsa006500.62250214
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60349771
60Peroxisome_Homo sapiens_hsa041460.60234750
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58766290
62Retinol metabolism_Homo sapiens_hsa008300.57869842
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57257609
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55631758
65Chemical carcinogenesis_Homo sapiens_hsa052040.55161276
66Metabolic pathways_Homo sapiens_hsa011000.54983465
67Systemic lupus erythematosus_Homo sapiens_hsa053220.53054963
68Olfactory transduction_Homo sapiens_hsa047400.52120784
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48878070
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47874004
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46231351
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45983446
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45018061
74p53 signaling pathway_Homo sapiens_hsa041150.44425884
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44264489
76Caffeine metabolism_Homo sapiens_hsa002320.43159083
77Antigen processing and presentation_Homo sapiens_hsa046120.43016309
78Fat digestion and absorption_Homo sapiens_hsa049750.42522978
79Staphylococcus aureus infection_Homo sapiens_hsa051500.40998253
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.40723722
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39985751
82Morphine addiction_Homo sapiens_hsa050320.38639908
83Ether lipid metabolism_Homo sapiens_hsa005650.32940727
84RNA transport_Homo sapiens_hsa030130.32790758
85Spliceosome_Homo sapiens_hsa030400.31866017
86Hematopoietic cell lineage_Homo sapiens_hsa046400.29925589
87Serotonergic synapse_Homo sapiens_hsa047260.29244403
88Arginine and proline metabolism_Homo sapiens_hsa003300.29118959
89Nitrogen metabolism_Homo sapiens_hsa009100.28188471
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26881678
91Vitamin digestion and absorption_Homo sapiens_hsa049770.25938280
92Cholinergic synapse_Homo sapiens_hsa047250.24805429
93Pyruvate metabolism_Homo sapiens_hsa006200.23215653
94Glutathione metabolism_Homo sapiens_hsa004800.21217889
95Tyrosine metabolism_Homo sapiens_hsa003500.21215333
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.19892048
97Sulfur metabolism_Homo sapiens_hsa009200.19580404
98Salivary secretion_Homo sapiens_hsa049700.19502483
99Hippo signaling pathway_Homo sapiens_hsa043900.18373877
100Taste transduction_Homo sapiens_hsa047420.18257358

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