ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	8.30745023
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	8.08618602
3	ATP synthesis coupled proton transport (GO:0015986)	8.08618602
4	viral transcription (GO:0019083)	7.25773184
5	translational termination (GO:0006415)	7.03320458
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.60833842
7	cotranslational protein targeting to membrane (GO:0006613)	6.48651020
8	protein targeting to ER (GO:0045047)	6.45784391
9	ribosomal small subunit assembly (GO:0000028)	6.38867003
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	6.36802396
11	ribosomal large subunit biogenesis (GO:0042273)	6.26227742
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.22307274
13	ribosomal small subunit biogenesis (GO:0042274)	6.20546022
14	protein localization to endoplasmic reticulum (GO:0070972)	6.16393965
15	respiratory electron transport chain (GO:0022904)	6.08257008
16	electron transport chain (GO:0022900)	5.96297950
17	translational elongation (GO:0006414)	5.93912098
18	cellular protein complex disassembly (GO:0043624)	5.30933367
19	viral life cycle (GO:0019058)	5.26729232
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.06352472
21	chaperone-mediated protein transport (GO:0072321)	5.05922188
22	translational initiation (GO:0006413)	5.05075115
23	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.05061491
24	translation (GO:0006412)	4.85371579
25	maturation of SSU-rRNA (GO:0030490)	4.76244814
26	ATP biosynthetic process (GO:0006754)	4.55942118
27	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.51336781
28	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.50722230
29	protein complex biogenesis (GO:0070271)	4.48428078
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.44070439
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.44070439
32	NADH dehydrogenase complex assembly (GO:0010257)	4.44070439
33	protein targeting to membrane (GO:0006612)	4.43180869
34	proteasome assembly (GO:0043248)	4.40137140
35	GTP biosynthetic process (GO:0006183)	4.36753215
36	protein complex disassembly (GO:0043241)	4.27635263
37	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.27586436
38	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.27586436
39	protein neddylation (GO:0045116)	4.24409258
40	mitochondrial respiratory chain complex assembly (GO:0033108)	4.14930506
41	hydrogen ion transmembrane transport (GO:1902600)	4.11365683
42	macromolecular complex disassembly (GO:0032984)	4.07849199
43	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.94841333
44	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.91891097
45	respiratory chain complex IV assembly (GO:0008535)	3.84668589
46	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.84370942
47	UTP biosynthetic process (GO:0006228)	3.79196089
48	ribonucleoprotein complex biogenesis (GO:0022613)	3.74017395
49	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.73646837
50	cellular component biogenesis (GO:0044085)	3.71182488
51	proton transport (GO:0015992)	3.68731989
52	regulation of cellular respiration (GO:0043457)	3.67076181
53	protein targeting to mitochondrion (GO:0006626)	3.65745222
54	hydrogen transport (GO:0006818)	3.63291675
55	mRNA catabolic process (GO:0006402)	3.53777192
56	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.47756109
57	termination of RNA polymerase III transcription (GO:0006386)	3.47756109
58	nucleoside triphosphate biosynthetic process (GO:0009142)	3.45746004
59	spliceosomal complex assembly (GO:0000245)	3.45447993
60	UTP metabolic process (GO:0046051)	3.44964527
61	oxidative phosphorylation (GO:0006119)	3.41357045
62	cytochrome complex assembly (GO:0017004)	3.38039031
63	regulation of hypersensitivity (GO:0002883)	3.37177075
64	establishment of protein localization to mitochondrion (GO:0072655)	3.32530426
65	protein localization to mitochondrion (GO:0070585)	3.32150515
66	aldehyde catabolic process (GO:0046185)	3.28380447
67	RNA catabolic process (GO:0006401)	3.25172260
68	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.22420515
69	rRNA processing (GO:0006364)	3.15768370
70	water-soluble vitamin biosynthetic process (GO:0042364)	3.15409780
71	establishment of protein localization to membrane (GO:0090150)	3.14265198
72	guanosine-containing compound biosynthetic process (GO:1901070)	3.12018163
73	protein targeting (GO:0006605)	3.11785107
74	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	3.06286615
75	purine nucleoside monophosphate biosynthetic process (GO:0009127)	3.06286615
76	negative regulation of heart rate (GO:0010459)	3.06045235
77	DNA deamination (GO:0045006)	3.05640796
78	mitochondrial transport (GO:0006839)	3.04813396
79	rRNA metabolic process (GO:0016072)	3.03835670
80	CTP metabolic process (GO:0046036)	2.99811976
81	CTP biosynthetic process (GO:0006241)	2.99811976
82	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.97654156
83	positive regulation of mast cell degranulation (GO:0043306)	2.97654156
84	GPI anchor biosynthetic process (GO:0006506)	2.94576086
85	deoxyribose phosphate catabolic process (GO:0046386)	2.93220914
86	rRNA modification (GO:0000154)	2.91818339
87	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.91690542
88	aerobic respiration (GO:0009060)	2.90666591
89	spliceosomal snRNP assembly (GO:0000387)	2.88751662
90	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.88397270
91	regulation of cellular amino acid metabolic process (GO:0006521)	2.87120674
92	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.84472344
93	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.84345454
94	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.83380857
95	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.81876336
96	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.78803702
97	preassembly of GPI anchor in ER membrane (GO:0016254)	2.78792930
98	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.76599924
99	GPI anchor metabolic process (GO:0006505)	2.76373123
100	establishment of protein localization to organelle (GO:0072594)	2.72813597

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	6.12241021
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.92305245
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.87648283
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.26294865
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.91515062
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.43438679
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.25569109
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.09604904
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.72395334
10	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.65876321
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.47944116
12	FOXP3_21729870_ChIP-Seq_TREG_Human	2.44848564
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.39143204
14	VDR_22108803_ChIP-Seq_LS180_Human	2.26890078
15	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.25812599
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.24408259
17	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.22116338
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.21671330
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.19245546
20	TTF2_22483619_ChIP-Seq_HELA_Human	2.10624773
21	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.88325570
22	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.87851491
23	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.84616572
24	DCP1A_22483619_ChIP-Seq_HELA_Human	1.80434366
25	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.78645337
26	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.75978704
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.75832744
28	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.73841110
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.73722335
30	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.68499273
31	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.60845371
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.60464986
33	ZNF274_21170338_ChIP-Seq_K562_Hela	1.60032491
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.57158691
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.56119189
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.55385526
37	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.51234208
38	XRN2_22483619_ChIP-Seq_HELA_Human	1.47825153
39	EWS_26573619_Chip-Seq_HEK293_Human	1.44251672
40	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.43117504
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.42496151
42	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.37813755
43	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35288955
44	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.33727089
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32657994
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32657994
47	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.32348523
48	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.32155084
49	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.31965138
50	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.30969615
51	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.27698657
52	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.27685945
53	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.27083940
54	TAF15_26573619_Chip-Seq_HEK293_Human	1.21878210
55	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.20844318
56	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.18724208
57	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.16983217
58	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16685233
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15447473
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15447473
61	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.13078036
62	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.11628610
63	AR_20517297_ChIP-Seq_VCAP_Human	1.10911276
64	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.09181592
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.09063415
66	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.08003312
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.07359948
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.07260713
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06556135
70	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.04897482
71	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.04682858
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03780615
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02699718
74	FUS_26573619_Chip-Seq_HEK293_Human	1.02411527
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00526680
76	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.00432709
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99631803
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.99161831
79	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.98478257
80	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98150198
81	TAF2_19829295_ChIP-Seq_ESCs_Human	0.98001281
82	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.96263014
83	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.95182101
84	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.94606505
85	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.94465221
86	NCOR_22424771_ChIP-Seq_293T_Human	0.93823701
87	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.92118144
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.90586735
89	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.90563148
90	CIITA_25753668_ChIP-Seq_RAJI_Human	0.88372274
91	ERG_20517297_ChIP-Seq_VCAP_Human	0.87719684
92	SPI1_23547873_ChIP-Seq_NB4_Human	0.87098310
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.86876482
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.85908052
95	GATA3_26560356_Chip-Seq_TH2_Human	0.85101127
96	P300_19829295_ChIP-Seq_ESCs_Human	0.83820439
97	IGF1R_20145208_ChIP-Seq_DFB_Human	0.83420705
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.82717972
99	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.82157976
100	NANOG_20526341_ChIP-Seq_ESCs_Human	0.81964574

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.02034161
2	MP0003806_abnormal_nucleotide_metabolis	4.70046552
3	MP0001835_abnormal_antigen_presentation	3.92649933
4	MP0006292_abnormal_olfactory_placode	2.70461609
5	MP0004142_abnormal_muscle_tone	2.43855955
6	MP0003186_abnormal_redox_activity	2.34320275
7	MP0006036_abnormal_mitochondrial_physio	2.20724338
8	MP0008875_abnormal_xenobiotic_pharmacok	2.18337519
9	MP0005671_abnormal_response_to	2.17859998
10	MP0005360_urolithiasis	2.14344250
11	MP0004145_abnormal_muscle_electrophysio	2.06515593
12	MP0003195_calcinosis	1.96849390
13	MP0002837_dystrophic_cardiac_calcinosis	1.93603219
14	MP0003646_muscle_fatigue	1.92989410
15	MP0005367_renal/urinary_system_phenotyp	1.85968633
16	MP0000516_abnormal_urinary_system	1.85968633
17	MP0005646_abnormal_pituitary_gland	1.81027989
18	MP0005075_abnormal_melanosome_morpholog	1.80213093
19	MP0002163_abnormal_gland_morphology	1.73226019
20	MP0008872_abnormal_physiological_respon	1.73167345
21	MP0004147_increased_porphyrin_level	1.65819152
22	MP0005332_abnormal_amino_acid	1.57283572
23	MP0002938_white_spotting	1.55863390
24	MP0005636_abnormal_mineral_homeostasis	1.53369544
25	MP0004885_abnormal_endolymph	1.51729066
26	MP0005085_abnormal_gallbladder_physiolo	1.48524328
27	MP0003786_premature_aging	1.48481919
28	MP0005670_abnormal_white_adipose	1.47751337
29	MP0009785_altered_susceptibility_to	1.46696121
30	MP0002876_abnormal_thyroid_physiology	1.45514201
31	MP0001905_abnormal_dopamine_level	1.43158124
32	MP0001529_abnormal_vocalization	1.40801597
33	MP0005408_hypopigmentation	1.39577245
34	MP0000372_irregular_coat_pigmentation	1.38554771
35	MP0002148_abnormal_hypersensitivity_rea	1.38110016
36	MP0009333_abnormal_splenocyte_physiolog	1.37908143
37	MP0001756_abnormal_urination	1.35671360
38	MP0001873_stomach_inflammation	1.33457970
39	MP0006072_abnormal_retinal_apoptosis	1.32581906
40	MP0000685_abnormal_immune_system	1.28655050
41	MP0001764_abnormal_homeostasis	1.26997908
42	MP0009764_decreased_sensitivity_to	1.24779173
43	MP0005379_endocrine/exocrine_gland_phen	1.24628003
44	MP0003718_maternal_effect	1.24575129
45	MP0005389_reproductive_system_phenotype	1.23798844
46	MP0002139_abnormal_hepatobiliary_system	1.19295570
47	MP0001440_abnormal_grooming_behavior	1.18894267
48	MP0001853_heart_inflammation	1.16487112
49	MP0006035_abnormal_mitochondrial_morpho	1.16243949
50	MP0001800_abnormal_humoral_immune	1.15772115
51	MP0002095_abnormal_skin_pigmentation	1.15232851
52	MP0002166_altered_tumor_susceptibility	1.14604323
53	MP0003567_abnormal_fetal_cardiomyocyte	1.13250888
54	MP0003123_paternal_imprinting	1.10195785
55	MP0003880_abnormal_central_pattern	1.09748318
56	MP0001986_abnormal_taste_sensitivity	1.05339103
57	MP0002102_abnormal_ear_morphology	1.04995482
58	MP0001919_abnormal_reproductive_system	1.04149565
59	MP0001765_abnormal_ion_homeostasis	1.03834842
60	MP0002272_abnormal_nervous_system	1.03133883
61	MP0004019_abnormal_vitamin_homeostasis	1.02490546
62	MP0002234_abnormal_pharynx_morphology	1.02072788
63	MP0009046_muscle_twitch	1.02017570
64	MP0005551_abnormal_eye_electrophysiolog	1.01829126
65	MP0002160_abnormal_reproductive_system	1.00150554
66	MP0003638_abnormal_response/metabolism_	0.98104527
67	MP0005084_abnormal_gallbladder_morpholo	0.97823259
68	MP0008058_abnormal_DNA_repair	0.97033041
69	MP0008877_abnormal_DNA_methylation	0.95393125
70	MP0010386_abnormal_urinary_bladder	0.94075104
71	MP0002006_tumorigenesis	0.90892810
72	MP0000631_abnormal_neuroendocrine_gland	0.90093626
73	MP0001970_abnormal_pain_threshold	0.89606440
74	MP0009643_abnormal_urine_homeostasis	0.88886348
75	MP0001293_anophthalmia	0.84533681
76	MP0003866_abnormal_defecation	0.84220408
77	MP0002736_abnormal_nociception_after	0.82410888
78	MP0003011_delayed_dark_adaptation	0.81074398
79	MP0005174_abnormal_tail_pigmentation	0.79656252
80	MP0001348_abnormal_lacrimal_gland	0.77737537
81	MP0002452_abnormal_antigen_presenting	0.75961745
82	MP0000049_abnormal_middle_ear	0.75177006
83	MP0001968_abnormal_touch/_nociception	0.73463181
84	MP0008469_abnormal_protein_level	0.72719681
85	MP0008775_abnormal_heart_ventricle	0.71802928
86	MP0010155_abnormal_intestine_physiology	0.71292450
87	MP0005319_abnormal_enzyme/_coenzyme	0.69888773
88	MP0006082_CNS_inflammation	0.69870763
89	MP0003724_increased_susceptibility_to	0.69237135
90	MP0005025_abnormal_response_to	0.68769017
91	MP0005365_abnormal_bile_salt	0.68767630
92	MP0008995_early_reproductive_senescence	0.68072741
93	MP0004742_abnormal_vestibular_system	0.67173694
94	MP0002723_abnormal_immune_serum	0.66914147
95	MP0001485_abnormal_pinna_reflex	0.66402221
96	MP0001663_abnormal_digestive_system	0.66011447
97	MP0001845_abnormal_inflammatory_respons	0.65887870
98	MP0006276_abnormal_autonomic_nervous	0.64016164
99	MP0005645_abnormal_hypothalamus_physiol	0.63320456
100	MP0000639_abnormal_adrenal_gland	0.63248341

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	6.86026330
2	Abnormal mitochondria in muscle tissue (HP:0008316)	6.13575582
3	Acute encephalopathy (HP:0006846)	5.86402971
4	Mitochondrial inheritance (HP:0001427)	5.82155424
5	Progressive macrocephaly (HP:0004481)	5.75458299
6	Hepatocellular necrosis (HP:0001404)	5.64022039
7	Increased CSF lactate (HP:0002490)	5.31750177
8	Hepatic necrosis (HP:0002605)	5.02292884
9	3-Methylglutaconic aciduria (HP:0003535)	4.95523090
10	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.50574905
11	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.50574905
12	Cerebral edema (HP:0002181)	4.41379731
13	Increased hepatocellular lipid droplets (HP:0006565)	4.31605731
14	Lipid accumulation in hepatocytes (HP:0006561)	4.01786487
15	Macrocytic anemia (HP:0001972)	3.95793551
16	Congenital, generalized hypertrichosis (HP:0004540)	3.77128686
17	Renal Fanconi syndrome (HP:0001994)	3.69143968
18	Abnormality of cells of the erythroid lineage (HP:0012130)	3.65989435
19	Exertional dyspnea (HP:0002875)	3.56015654
20	Reticulocytopenia (HP:0001896)	3.54835069
21	Respiratory failure (HP:0002878)	3.50231907
22	Leukodystrophy (HP:0002415)	3.49343944
23	Increased serum lactate (HP:0002151)	3.41914519
24	Lactic acidosis (HP:0003128)	3.40704740
25	Increased intramyocellular lipid droplets (HP:0012240)	3.26795756
26	Optic disc pallor (HP:0000543)	3.18837965
27	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.17814972
28	Abnormal number of erythroid precursors (HP:0012131)	2.96490561
29	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.89386382
30	Abnormality of alanine metabolism (HP:0010916)	2.89386382
31	Hyperalaninemia (HP:0003348)	2.89386382
32	Exercise intolerance (HP:0003546)	2.84675241
33	Pallor (HP:0000980)	2.81633768
34	Lethargy (HP:0001254)	2.80317783
35	Increased muscle lipid content (HP:0009058)	2.79194765
36	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.69005491
37	Molar tooth sign on MRI (HP:0002419)	2.67889078
38	Abnormality of midbrain morphology (HP:0002418)	2.67889078
39	Abnormality of renal resorption (HP:0011038)	2.62001684
40	Glycosuria (HP:0003076)	2.48709062
41	Abnormality of urine glucose concentration (HP:0011016)	2.48709062
42	CNS demyelination (HP:0007305)	2.48562000
43	Cleft eyelid (HP:0000625)	2.45294134
44	Respiratory difficulties (HP:0002880)	2.44685933
45	Aplastic anemia (HP:0001915)	2.40129703
46	Microvesicular hepatic steatosis (HP:0001414)	2.38782230
47	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.35564646
48	Hyperphosphaturia (HP:0003109)	2.18436101
49	Abnormality of serum amino acid levels (HP:0003112)	2.14790156
50	X-linked dominant inheritance (HP:0001423)	2.07361557
51	Generalized aminoaciduria (HP:0002909)	2.07034596
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.06375854
53	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.05287900
54	Abnormality of magnesium homeostasis (HP:0004921)	2.02856313
55	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.99192664
56	Abolished electroretinogram (ERG) (HP:0000550)	1.99032668
57	Hyperglycinemia (HP:0002154)	1.97422424
58	Hypoplasia of the uterus (HP:0000013)	1.97066898
59	Increased serum pyruvate (HP:0003542)	1.96638447
60	Testicular atrophy (HP:0000029)	1.95318635
61	Type I transferrin isoform profile (HP:0003642)	1.94795718
62	Hypothermia (HP:0002045)	1.93372138
63	Congenital stationary night blindness (HP:0007642)	1.90882310
64	Pancreatic cysts (HP:0001737)	1.89055331
65	Dyschromatopsia (HP:0007641)	1.88765649
66	Vomiting (HP:0002013)	1.88679729
67	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.88013819
68	Aplasia/hypoplasia of the uterus (HP:0008684)	1.86759377
69	Parakeratosis (HP:0001036)	1.83406773
70	Constricted visual fields (HP:0001133)	1.82621502
71	Abnormal hemoglobin (HP:0011902)	1.81453538
72	Blindness (HP:0000618)	1.81103992
73	Stenosis of the external auditory canal (HP:0000402)	1.80331979
74	Woolly hair (HP:0002224)	1.80254982
75	Abnormal urine phosphate concentration (HP:0012599)	1.79768502
76	Abnormal rod and cone electroretinograms (HP:0008323)	1.79037017
77	Amniotic constriction ring (HP:0009775)	1.78614975
78	Abnormality of placental membranes (HP:0011409)	1.78614975
79	Emotional lability (HP:0000712)	1.77114163
80	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.74074051
81	Methylmalonic acidemia (HP:0002912)	1.73109160
82	Hypoproteinemia (HP:0003075)	1.70996044
83	Hypomagnesemia (HP:0002917)	1.70036810
84	Reduced antithrombin III activity (HP:0001976)	1.69870458
85	True hermaphroditism (HP:0010459)	1.69745666
86	Spastic paraparesis (HP:0002313)	1.69698218
87	Gliosis (HP:0002171)	1.66950932
88	Methylmalonic aciduria (HP:0012120)	1.66196671
89	Congenital ichthyosiform erythroderma (HP:0007431)	1.65071187
90	Triphalangeal thumb (HP:0001199)	1.63284942
91	Sensory axonal neuropathy (HP:0003390)	1.62287140
92	Abnormality of the anterior horn cell (HP:0006802)	1.61460446
93	Degeneration of anterior horn cells (HP:0002398)	1.61460446
94	Porencephaly (HP:0002132)	1.60728624
95	Sclerocornea (HP:0000647)	1.60720226
96	Hypoplasia of the ulna (HP:0003022)	1.60417636
97	Pancreatic fibrosis (HP:0100732)	1.59157251
98	Male pseudohermaphroditism (HP:0000037)	1.59117787
99	IgG deficiency (HP:0004315)	1.56952139
100	Hypoplasia of the radius (HP:0002984)	1.53774038

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K12	5.96621270
2	MYLK	3.60778880
3	NME2	3.56385481
4	BMPR2	3.40391733
5	CDK19	3.30171710
6	TLK1	2.74570248
7	STK16	2.45140126
8	ILK	2.38944276
9	NUAK1	2.24460054
10	MAP4K2	2.20401053
11	WNK4	2.01320627
12	SCYL2	1.88674993
13	GRK1	1.84381210
14	TIE1	1.80714420
15	MST4	1.59209592
16	OXSR1	1.55211409
17	PDK2	1.52906327
18	DAPK3	1.51386270
19	CSF1R	1.49243079
20	VRK2	1.44677292
21	ERBB3	1.40023450
22	NEK1	1.39630108
23	EIF2AK1	1.37685256
24	TEC	1.36761129
25	FRK	1.35865144
26	ADRBK2	1.29293358
27	DYRK2	1.26937144
28	TAOK3	1.25262575
29	PLK4	1.22145999
30	IKBKB	1.21092542
31	DAPK1	1.16917717
32	STK39	1.14787385
33	TXK	1.08925511
34	LRRK2	1.08570249
35	INSRR	1.08370797
36	TRIM28	1.06877397
37	STK24	1.05904279
38	BCKDK	1.04930471
39	PAK4	1.03851820
40	FLT3	1.02572037
41	WNK3	1.02442520
42	TRPM7	1.01433539
43	PASK	1.00617028
44	ZAK	0.96848317
45	AURKB	0.93004992
46	EIF2AK3	0.91272019
47	ITK	0.91242118
48	BUB1	0.87180999
49	BMPR1B	0.84721295
50	ABL2	0.81025401
51	CSNK2A2	0.81014779
52	PBK	0.78445043
53	STK3	0.76148188
54	KIT	0.75930507
55	LYN	0.74230631
56	CSNK2A1	0.73309272
57	NME1	0.72657827
58	GRK7	0.71750188
59	FES	0.67715442
60	KDR	0.60864950
61	OBSCN	0.60493373
62	ADRBK1	0.55032844
63	CDC7	0.54641795
64	RPS6KA5	0.53203898
65	VRK1	0.52490357
66	STK38L	0.51991335
67	MAP4K1	0.48914053
68	BTK	0.48281925
69	PRKCE	0.47731455
70	PRKACA	0.46907877
71	GRK6	0.46331542
72	CDK8	0.46135469
73	EPHA4	0.45196341
74	ACVR1B	0.44186054
75	MAP2K6	0.43669094
76	SRPK1	0.43071593
77	CAMK2D	0.42580773
78	ATR	0.42054304
79	SYK	0.41268247
80	PIK3CG	0.41074370
81	ROCK1	0.40310701
82	PRKCA	0.40237671
83	PRKCD	0.39392171
84	PRKG1	0.37134721
85	CSNK1A1	0.36866778
86	PLK3	0.36341208
87	MUSK	0.35708191
88	RPS6KB2	0.35643265
89	IGF1R	0.34516486
90	CSNK1E	0.34177123
91	PLK1	0.33542299
92	PAK1	0.33165898
93	CSNK1G3	0.32454032
94	RPS6KA4	0.31301390
95	CSNK1G2	0.30709137
96	PIM1	0.30636048
97	MATK	0.30559688
98	MINK1	0.29356604
99	TAF1	0.29233089
100	CAMK1	0.28265755

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.99956891
2	Ribosome_Homo sapiens_hsa03010	4.90656014
3	Oxidative phosphorylation_Homo sapiens_hsa00190	4.38858874
4	Parkinsons disease_Homo sapiens_hsa05012	3.51382658
5	Allograft rejection_Homo sapiens_hsa05330	3.29255346
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.14254599
7	Protein export_Homo sapiens_hsa03060	3.13093146
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.99191343
9	Proteasome_Homo sapiens_hsa03050	2.97096404
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.77713821
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.64712539
12	Alzheimers disease_Homo sapiens_hsa05010	2.41401890
13	Huntingtons disease_Homo sapiens_hsa05016	2.40955695
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.16621907
15	RNA polymerase_Homo sapiens_hsa03020	1.88884877
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.87069284
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.72353254
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.54587398
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.48059892
20	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.46889576
21	One carbon pool by folate_Homo sapiens_hsa00670	1.46226843
22	Viral myocarditis_Homo sapiens_hsa05416	1.34576672
23	Antigen processing and presentation_Homo sapiens_hsa04612	1.33728654
24	Homologous recombination_Homo sapiens_hsa03440	1.24012712
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.20548832
26	RNA degradation_Homo sapiens_hsa03018	1.10186792
27	Mismatch repair_Homo sapiens_hsa03430	1.08809941
28	Leishmaniasis_Homo sapiens_hsa05140	0.96726876
29	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95972690
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.92851533
31	Spliceosome_Homo sapiens_hsa03040	0.85429933
32	Nucleotide excision repair_Homo sapiens_hsa03420	0.84220443
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.83326943
34	Propanoate metabolism_Homo sapiens_hsa00640	0.83063447
35	DNA replication_Homo sapiens_hsa03030	0.82492495
36	Regulation of autophagy_Homo sapiens_hsa04140	0.81727094
37	Basal transcription factors_Homo sapiens_hsa03022	0.80577273
38	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.80036996
39	Collecting duct acid secretion_Homo sapiens_hsa04966	0.77323655
40	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.74943759
41	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74016660
42	Phototransduction_Homo sapiens_hsa04744	0.70549368
43	RNA transport_Homo sapiens_hsa03013	0.70175967
44	Linoleic acid metabolism_Homo sapiens_hsa00591	0.70156143
45	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.69778892
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.68263834
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68050709
48	Fanconi anemia pathway_Homo sapiens_hsa03460	0.66063677
49	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62712263
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62239936
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61478918
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.60771969
53	Purine metabolism_Homo sapiens_hsa00230	0.60324282
54	Folate biosynthesis_Homo sapiens_hsa00790	0.60173237
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60013848
56	Sulfur metabolism_Homo sapiens_hsa00920	0.59926018
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.58463270
58	Metabolic pathways_Homo sapiens_hsa01100	0.57915944
59	Fatty acid degradation_Homo sapiens_hsa00071	0.55947123
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53258189
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.53136399
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.52784240
63	Pyruvate metabolism_Homo sapiens_hsa00620	0.52720521
64	Peroxisome_Homo sapiens_hsa04146	0.51752160
65	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.50778821
66	Sulfur relay system_Homo sapiens_hsa04122	0.50777018
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49729019
68	Glutathione metabolism_Homo sapiens_hsa00480	0.49318169
69	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.48294236
70	Retinol metabolism_Homo sapiens_hsa00830	0.48031092
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.45611593
72	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44015390
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42049285
74	Base excision repair_Homo sapiens_hsa03410	0.41572975
75	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37615551
76	Caffeine metabolism_Homo sapiens_hsa00232	0.37217065
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36772673
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.33676555
79	Phagosome_Homo sapiens_hsa04145	0.32992183
80	Toxoplasmosis_Homo sapiens_hsa05145	0.32053672
81	Nitrogen metabolism_Homo sapiens_hsa00910	0.31985581
82	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.31838735
83	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.30328599
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30103749
85	Fatty acid elongation_Homo sapiens_hsa00062	0.28839924
86	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.28360252
87	Tyrosine metabolism_Homo sapiens_hsa00350	0.27651683
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.27651582
89	Butanoate metabolism_Homo sapiens_hsa00650	0.26579245
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.25718844
91	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.25586954
92	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.24994805
93	Herpes simplex infection_Homo sapiens_hsa05168	0.24628343
94	Tuberculosis_Homo sapiens_hsa05152	0.24074318
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.23595825
96	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.23258338
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.22221172
98	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.21676458
99	Renin-angiotensin system_Homo sapiens_hsa04614	0.20334923
100	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.19919768

RPL12P14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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