ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.54787397
2	translational termination (GO:0006415)	8.24416736
3	ribosomal small subunit assembly (GO:0000028)	7.91018662
4	ribosomal small subunit biogenesis (GO:0042274)	7.36937492
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.16967371
6	cotranslational protein targeting to membrane (GO:0006613)	7.07460271
7	protein targeting to ER (GO:0045047)	7.02455418
8	translational elongation (GO:0006414)	6.94305575
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.74918122
10	protein localization to endoplasmic reticulum (GO:0070972)	6.61730278
11	ATP synthesis coupled proton transport (GO:0015986)	6.37846051
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.37846051
13	maturation of SSU-rRNA (GO:0030490)	6.23220448
14	cellular protein complex disassembly (GO:0043624)	6.20891878
15	viral life cycle (GO:0019058)	6.20651508
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.07352060
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.92970924
18	translational initiation (GO:0006413)	5.67327965
19	ribosomal large subunit biogenesis (GO:0042273)	5.62475814
20	protein complex disassembly (GO:0043241)	5.17306608
21	chaperone-mediated protein transport (GO:0072321)	4.97133051
22	macromolecular complex disassembly (GO:0032984)	4.93107626
23	translation (GO:0006412)	4.85328931
24	protein targeting to membrane (GO:0006612)	4.77136880
25	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.69007975
26	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.52472945
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.44724218
28	ribonucleoprotein complex biogenesis (GO:0022613)	4.40138127
29	mRNA catabolic process (GO:0006402)	4.31146918
30	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.28876191
31	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.27312950
32	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.22413782
33	respiratory electron transport chain (GO:0022904)	4.20693720
34	GTP biosynthetic process (GO:0006183)	4.19101180
35	electron transport chain (GO:0022900)	4.16004786
36	cellular component biogenesis (GO:0044085)	4.07872812
37	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.98715137
38	RNA catabolic process (GO:0006401)	3.94563247
39	protein complex biogenesis (GO:0070271)	3.94422532
40	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.89758336
41	protein neddylation (GO:0045116)	3.88612825
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.85112727
43	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.81112870
44	NADH dehydrogenase complex assembly (GO:0010257)	3.81112870
45	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.81112870
46	ATP biosynthetic process (GO:0006754)	3.80492174
47	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.68557080
48	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.68557080
49	mitochondrial respiratory chain complex assembly (GO:0033108)	3.65459209
50	behavioral response to nicotine (GO:0035095)	3.65449789
51	spliceosomal complex assembly (GO:0000245)	3.63207543
52	UTP biosynthetic process (GO:0006228)	3.61514214
53	rRNA processing (GO:0006364)	3.54769608
54	rRNA metabolic process (GO:0016072)	3.52462773
55	hydrogen ion transmembrane transport (GO:1902600)	3.44664066
56	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.42735345
57	regulation of isotype switching to IgG isotypes (GO:0048302)	3.38257922
58	DNA deamination (GO:0045006)	3.32687175
59	UTP metabolic process (GO:0046051)	3.31842252
60	water-soluble vitamin biosynthetic process (GO:0042364)	3.31283047
61	establishment of protein localization to membrane (GO:0090150)	3.18178273
62	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.18106509
63	termination of RNA polymerase III transcription (GO:0006386)	3.18106509
64	regulation of immunoglobulin secretion (GO:0051023)	3.15159231
65	protein targeting (GO:0006605)	3.14719389
66	proton transport (GO:0015992)	3.10122969
67	nonmotile primary cilium assembly (GO:0035058)	3.09472546
68	hydrogen transport (GO:0006818)	3.04466487
69	guanosine-containing compound biosynthetic process (GO:1901070)	3.01965005
70	respiratory chain complex IV assembly (GO:0008535)	2.99562654
71	CTP metabolic process (GO:0046036)	2.97882708
72	CTP biosynthetic process (GO:0006241)	2.97882708
73	rRNA catabolic process (GO:0016075)	2.95664394
74	establishment of protein localization to organelle (GO:0072594)	2.93444646
75	ribosome biogenesis (GO:0042254)	2.92562330
76	nucleoside triphosphate biosynthetic process (GO:0009142)	2.87068604
77	hypothalamus development (GO:0021854)	2.86901499
78	cytochrome complex assembly (GO:0017004)	2.84291464
79	somite development (GO:0061053)	2.83021548
80	regulation of activation of Janus kinase activity (GO:0010533)	2.82357869
81	protein-cofactor linkage (GO:0018065)	2.75490507
82	tRNA processing (GO:0008033)	2.73641949
83	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.69640576
84	regulation of mitotic spindle checkpoint (GO:1903504)	2.69640576
85	ncRNA processing (GO:0034470)	2.69360156
86	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.68481675
87	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.68481675
88	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.63026482
89	ncRNA catabolic process (GO:0034661)	2.62910769
90	protein targeting to mitochondrion (GO:0006626)	2.60276138
91	preassembly of GPI anchor in ER membrane (GO:0016254)	2.58192263
92	signal peptide processing (GO:0006465)	2.56796295
93	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.56015724
94	head development (GO:0060322)	2.55750942
95	ncRNA metabolic process (GO:0034660)	2.54255988
96	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.53649663
97	intracellular protein transmembrane import (GO:0044743)	2.52448762
98	establishment of protein localization to mitochondrion (GO:0072655)	2.51798628
99	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.51517995
100	ncRNA 3-end processing (GO:0043628)	2.49244960

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.90347948
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.36478464
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.33943167
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.31947349
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.99337262
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.60335882
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.32832724
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.20646914
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.16084814
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.56486180
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.51789323
12	TTF2_22483619_ChIP-Seq_HELA_Human	2.47708275
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.42583749
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.27272863
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.26209517
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.24338460
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.24190178
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.21798134
19	VDR_22108803_ChIP-Seq_LS180_Human	2.16049657
20	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.12968999
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.10915661
22	EWS_26573619_Chip-Seq_HEK293_Human	1.86682941
23	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.85369915
24	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.83032459
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80078655
26	XRN2_22483619_ChIP-Seq_HELA_Human	1.78106782
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.74004272
28	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.73713541
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.69756622
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.68925220
31	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.61610717
32	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.57956719
33	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.57887775
34	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.57550354
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.55059836
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52146842
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52135184
38	GABP_19822575_ChIP-Seq_HepG2_Human	1.51121976
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50906177
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.49656320
41	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.47612590
42	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.47605398
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.43253534
44	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.41584270
45	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.37332000
46	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.27940332
47	DCP1A_22483619_ChIP-Seq_HELA_Human	1.26329832
48	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.24611151
49	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22590932
50	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.22017714
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19306116
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19247071
53	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.18866737
54	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.17987812
55	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.16162199
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14716012
57	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.14409789
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13815608
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13815608
60	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.08719407
61	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.01054263
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.00696956
63	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.00449446
64	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.99853126
65	ERA_21632823_ChIP-Seq_H3396_Human	0.97791693
66	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97660611
67	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97428002
68	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96093690
69	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.95621883
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94750992
71	AR_20517297_ChIP-Seq_VCAP_Human	0.94691228
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.93365326
73	FUS_26573619_Chip-Seq_HEK293_Human	0.92445155
74	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.92184371
75	NCOR_22424771_ChIP-Seq_293T_Human	0.91600594
76	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.91445147
77	P53_21459846_ChIP-Seq_SAOS-2_Human	0.89211016
78	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.88876584
79	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.88110870
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.87752390
81	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.87720608
82	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.87517106
83	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.86018828
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.85295013
85	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.84806995
86	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.84791504
87	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.84671306
88	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.84042215
89	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.83989645
90	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.82817028
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.82471592
92	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.81025809
93	KDM5A_27292631_Chip-Seq_BREAST_Human	0.80863647
94	P300_19829295_ChIP-Seq_ESCs_Human	0.80197030
95	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.79834249
96	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.79393562
97	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.79372774
98	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.78572408
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.77812000
100	STAT1_20625510_ChIP-Seq_HELA_Human	0.76955834

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.47384422
2	MP0006292_abnormal_olfactory_placode	4.34382578
3	MP0008789_abnormal_olfactory_epithelium	2.70962561
4	MP0001348_abnormal_lacrimal_gland	2.51824609
5	MP0001835_abnormal_antigen_presentation	2.50934737
6	MP0001293_anophthalmia	2.44435943
7	MP0003011_delayed_dark_adaptation	2.20669968
8	MP0002163_abnormal_gland_morphology	2.16091908
9	MP0001529_abnormal_vocalization	2.13777263
10	MP0008875_abnormal_xenobiotic_pharmacok	2.07659412
11	MP0008877_abnormal_DNA_methylation	2.07294564
12	MP0006072_abnormal_retinal_apoptosis	2.05026399
13	MP0005377_hearing/vestibular/ear_phenot	2.04944612
14	MP0003878_abnormal_ear_physiology	2.04944612
15	MP0004142_abnormal_muscle_tone	2.02977150
16	MP0010030_abnormal_orbit_morphology	2.00021230
17	MP0000049_abnormal_middle_ear	1.97593072
18	MP0005499_abnormal_olfactory_system	1.96027873
19	MP0005394_taste/olfaction_phenotype	1.96027873
20	MP0008872_abnormal_physiological_respon	1.95239351
21	MP0002102_abnormal_ear_morphology	1.93918705
22	MP0005379_endocrine/exocrine_gland_phen	1.90802464
23	MP0002638_abnormal_pupillary_reflex	1.84465948
24	MP0005671_abnormal_response_to	1.71640404
25	MP0002234_abnormal_pharynx_morphology	1.69690847
26	MP0004885_abnormal_endolymph	1.68123570
27	MP0003646_muscle_fatigue	1.65483202
28	MP0003186_abnormal_redox_activity	1.64215569
29	MP0002938_white_spotting	1.62580206
30	MP0005551_abnormal_eye_electrophysiolog	1.55139032
31	MP0003786_premature_aging	1.47449339
32	MP0002653_abnormal_ependyma_morphology	1.39318684
33	MP0000631_abnormal_neuroendocrine_gland	1.38944703
34	MP0005253_abnormal_eye_physiology	1.38264665
35	MP0001502_abnormal_circadian_rhythm	1.36506161
36	MP0004133_heterotaxia	1.32799801
37	MP0002095_abnormal_skin_pigmentation	1.30832273
38	MP0000685_abnormal_immune_system	1.29312220
39	MP0000566_synostosis	1.25836743
40	MP0003880_abnormal_central_pattern	1.21627178
41	MP0003195_calcinosis	1.20855054
42	MP0002160_abnormal_reproductive_system	1.20125590
43	MP0001968_abnormal_touch/_nociception	1.15540768
44	MP0002876_abnormal_thyroid_physiology	1.15387485
45	MP0002736_abnormal_nociception_after	1.14620597
46	MP0003567_abnormal_fetal_cardiomyocyte	1.13625023
47	MP0001984_abnormal_olfaction	1.13625010
48	MP0002272_abnormal_nervous_system	1.12985985
49	MP0005389_reproductive_system_phenotype	1.12125013
50	MP0001905_abnormal_dopamine_level	1.10824040
51	MP0001485_abnormal_pinna_reflex	1.07745108
52	MP0002277_abnormal_respiratory_mucosa	1.05800982
53	MP0005387_immune_system_phenotype	1.03681940
54	MP0001790_abnormal_immune_system	1.03681940
55	MP0003121_genomic_imprinting	1.00821075
56	MP0005646_abnormal_pituitary_gland	1.00709479
57	MP0004742_abnormal_vestibular_system	1.00616840
58	MP0001873_stomach_inflammation	0.98971296
59	MP0003136_yellow_coat_color	0.97701537
60	MP0001286_abnormal_eye_development	0.97318955
61	MP0005391_vision/eye_phenotype	0.97032561
62	MP0003806_abnormal_nucleotide_metabolis	0.96605070
63	MP0003283_abnormal_digestive_organ	0.96603233
64	MP0006276_abnormal_autonomic_nervous	0.96469334
65	MP0003787_abnormal_imprinting	0.95827251
66	MP0002233_abnormal_nose_morphology	0.95576964
67	MP0001800_abnormal_humoral_immune	0.94349667
68	MP0003937_abnormal_limbs/digits/tail_de	0.94262626
69	MP0000427_abnormal_hair_cycle	0.93734217
70	MP0005075_abnormal_melanosome_morpholog	0.93377775
71	MP0003122_maternal_imprinting	0.93036838
72	MP0002132_abnormal_respiratory_system	0.91850099
73	MP0003938_abnormal_ear_development	0.91395545
74	MP0005195_abnormal_posterior_eye	0.91173774
75	MP0002210_abnormal_sex_determination	0.90166777
76	MP0003183_abnormal_peptide_metabolism	0.87325248
77	MP0005645_abnormal_hypothalamus_physiol	0.85338097
78	MP0004782_abnormal_surfactant_physiolog	0.83430948
79	MP0004145_abnormal_muscle_electrophysio	0.82364271
80	MP0009745_abnormal_behavioral_response	0.80498761
81	MP0001970_abnormal_pain_threshold	0.80310130
82	MP0009053_abnormal_anal_canal	0.80145931
83	MP0003123_paternal_imprinting	0.79024324
84	MP0005423_abnormal_somatic_nervous	0.78480442
85	MP0003936_abnormal_reproductive_system	0.77914071
86	MP0000026_abnormal_inner_ear	0.77347984
87	MP0000647_abnormal_sebaceous_gland	0.75263498
88	MP0002184_abnormal_innervation	0.74394650
89	MP0001663_abnormal_digestive_system	0.73429238
90	MP0006036_abnormal_mitochondrial_physio	0.73375431
91	MP0002148_abnormal_hypersensitivity_rea	0.72237406
92	MP0005084_abnormal_gallbladder_morpholo	0.70715769
93	MP0003718_maternal_effect	0.67687080
94	MP0003693_abnormal_embryo_hatching	0.67357289
95	MP0008995_early_reproductive_senescence	0.66626696
96	MP0005408_hypopigmentation	0.66450963
97	MP0002837_dystrophic_cardiac_calcinosis	0.65509733
98	MP0000778_abnormal_nervous_system	0.64153235
99	MP0001145_abnormal_male_reproductive	0.63009934
100	MP0001440_abnormal_grooming_behavior	0.62800725

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.69293146
2	Acute necrotizing encephalopathy (HP:0006965)	4.67692027
3	Mitochondrial inheritance (HP:0001427)	4.27829182
4	3-Methylglutaconic aciduria (HP:0003535)	4.22287424
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.20294845
6	Macrocytic anemia (HP:0001972)	4.07560204
7	Acute encephalopathy (HP:0006846)	3.99001306
8	Abnormality of cells of the erythroid lineage (HP:0012130)	3.97843804
9	Increased CSF lactate (HP:0002490)	3.78193916
10	Progressive macrocephaly (HP:0004481)	3.77108310
11	Hepatocellular necrosis (HP:0001404)	3.76451764
12	Increased hepatocellular lipid droplets (HP:0006565)	3.49786674
13	Congenital, generalized hypertrichosis (HP:0004540)	3.48789093
14	Rib fusion (HP:0000902)	3.43367630
15	Lipid accumulation in hepatocytes (HP:0006561)	3.33158447
16	Hepatic necrosis (HP:0002605)	3.32850713
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.12108831
18	Congenital stationary night blindness (HP:0007642)	3.08466245
19	Pallor (HP:0000980)	3.05714687
20	Abnormal number of erythroid precursors (HP:0012131)	3.05684768
21	Abnormality of midbrain morphology (HP:0002418)	3.02390538
22	Molar tooth sign on MRI (HP:0002419)	3.02390538
23	Stomatitis (HP:0010280)	2.97432446
24	Cerebral edema (HP:0002181)	2.94186775
25	Pancreatic fibrosis (HP:0100732)	2.90261348
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.88582723
27	Severe combined immunodeficiency (HP:0004430)	2.86665569
28	B lymphocytopenia (HP:0010976)	2.86114497
29	Septo-optic dysplasia (HP:0100842)	2.79126191
30	Panhypogammaglobulinemia (HP:0003139)	2.75820124
31	Abnormality of B cell number (HP:0010975)	2.75549525
32	Optic disc pallor (HP:0000543)	2.73723190
33	Increased intramyocellular lipid droplets (HP:0012240)	2.72563509
34	Pancreatic cysts (HP:0001737)	2.67013026
35	Increased serum lactate (HP:0002151)	2.62443709
36	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.58439029
37	Renal Fanconi syndrome (HP:0001994)	2.55848181
38	IgG deficiency (HP:0004315)	2.53884347
39	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.48262629
40	Respiratory failure (HP:0002878)	2.42910474
41	Thyroiditis (HP:0100646)	2.39151978
42	Hypoproteinemia (HP:0003075)	2.39045927
43	Bile duct proliferation (HP:0001408)	2.36749217
44	Abnormal biliary tract physiology (HP:0012439)	2.36749217
45	Exertional dyspnea (HP:0002875)	2.36307126
46	Lactic acidosis (HP:0003128)	2.34402850
47	Dyschromatopsia (HP:0007641)	2.34179989
48	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.33638138
49	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.33638138
50	Hypoplasia of the thymus (HP:0000778)	2.33232600
51	Abnormality of the labia minora (HP:0012880)	2.33115569
52	Abnormal ciliary motility (HP:0012262)	2.32417333
53	Increased muscle lipid content (HP:0009058)	2.30520389
54	Colon cancer (HP:0003003)	2.26191768
55	Growth hormone deficiency (HP:0000824)	2.24944542
56	Anophthalmia (HP:0000528)	2.19452823
57	Abnormality of the renal cortex (HP:0011035)	2.16702294
58	True hermaphroditism (HP:0010459)	2.16684135
59	Hyperglycinemia (HP:0002154)	2.16387956
60	Medial flaring of the eyebrow (HP:0010747)	2.15964558
61	Aplasia/hypoplasia of the uterus (HP:0008684)	2.15179657
62	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.14821628
63	Abnormal respiratory motile cilium physiology (HP:0012261)	2.14074665
64	Type II lissencephaly (HP:0007260)	2.13667165
65	Sclerocornea (HP:0000647)	2.09925655
66	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.09181391
67	Combined immunodeficiency (HP:0005387)	2.08193225
68	Pendular nystagmus (HP:0012043)	2.07499075
69	Abolished electroretinogram (ERG) (HP:0000550)	2.07013725
70	Exercise intolerance (HP:0003546)	2.06527557
71	Asplenia (HP:0001746)	2.04949423
72	Hypoplasia of the uterus (HP:0000013)	2.03373089
73	Absent thumb (HP:0009777)	2.03073689
74	Abnormal respiratory epithelium morphology (HP:0012253)	2.01358966
75	Abnormal respiratory motile cilium morphology (HP:0005938)	2.01358966
76	Respiratory difficulties (HP:0002880)	1.97352585
77	Abnormality of alanine metabolism (HP:0010916)	1.96858826
78	Hyperalaninemia (HP:0003348)	1.96858826
79	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.96858826
80	Methylmalonic acidemia (HP:0002912)	1.92620533
81	Nephronophthisis (HP:0000090)	1.91435289
82	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.91120997
83	Leukodystrophy (HP:0002415)	1.91102081
84	Cleft eyelid (HP:0000625)	1.90994045
85	Lethargy (HP:0001254)	1.90020586
86	Hypoplasia of the radius (HP:0002984)	1.86749771
87	Abnormality of renal resorption (HP:0011038)	1.85728576
88	Supernumerary spleens (HP:0009799)	1.84375872
89	Constricted visual fields (HP:0001133)	1.83594915
90	Depressed nasal ridge (HP:0000457)	1.82949070
91	Tubular atrophy (HP:0000092)	1.82566785
92	Increased IgM level (HP:0003496)	1.82525755
93	Adrenal hypoplasia (HP:0000835)	1.82135871
94	Thyroid-stimulating hormone excess (HP:0002925)	1.81180223
95	Cystic liver disease (HP:0006706)	1.76341419
96	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.75332786
97	Hypoplasia of the fovea (HP:0007750)	1.75332786
98	Erythroderma (HP:0001019)	1.73411923
99	Elevated erythrocyte sedimentation rate (HP:0003565)	1.72340186
100	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.71697707

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.18859109
2	BMPR1B	2.81776122
3	TXK	2.79591236
4	NUAK1	2.61209180
5	GRK1	2.46883216
6	MAP4K2	2.46143326
7	ADRBK2	2.35218421
8	NME1	2.32827802
9	TIE1	2.26743945
10	VRK2	2.21009492
11	EPHB2	2.14414617
12	NME2	2.08894231
13	MAP4K1	1.97626572
14	EIF2AK1	1.95201263
15	LRRK2	1.91115443
16	CDK19	1.89932077
17	MAP3K12	1.81358056
18	DYRK2	1.71995072
19	STK16	1.68816514
20	WNK3	1.68252502
21	ZAK	1.66962791
22	PLK4	1.65944661
23	PINK1	1.56736914
24	PASK	1.52991338
25	CDC7	1.52758811
26	TGFBR1	1.50969454
27	NEK1	1.46554052
28	TLK1	1.43487966
29	STK39	1.42239911
30	PIK3CA	1.41217887
31	CDK8	1.36923142
32	TEC	1.33896069
33	EPHA4	1.29523808
34	FRK	1.27191961
35	VRK1	1.26485241
36	PLK2	1.18459778
37	BCKDK	1.13644530
38	MKNK2	1.08636132
39	EIF2AK3	1.07457613
40	MAP3K11	1.04153556
41	PLK3	1.00668334
42	OXSR1	1.00543196
43	SRPK1	0.92093069
44	TSSK6	0.89028104
45	CAMK1	0.87565208
46	PLK1	0.82829826
47	BUB1	0.82618513
48	IKBKB	0.79940222
49	CSNK2A2	0.79883084
50	MAP3K4	0.78929616
51	IRAK4	0.74228421
52	DAPK3	0.72357774
53	PAK3	0.71618981
54	ITK	0.70916292
55	AURKB	0.69223068
56	CAMK1D	0.66015801
57	GRK6	0.64770296
58	PRKCG	0.64664314
59	TYRO3	0.64496919
60	STK4	0.63030792
61	CAMK1G	0.62814589
62	ADRBK1	0.62464094
63	CAMKK2	0.61644760
64	INSRR	0.61278919
65	AURKA	0.58634294
66	CSNK2A1	0.56080783
67	TAOK3	0.55906304
68	PNCK	0.54667908
69	BTK	0.53853731
70	SYK	0.52040362
71	ATR	0.51657347
72	PDK2	0.50476591
73	CSNK1E	0.49994224
74	NLK	0.49247036
75	MKNK1	0.49119806
76	FES	0.46860678
77	PRKCI	0.45894286
78	RPS6KA6	0.45830956
79	STK11	0.45826371
80	TAF1	0.45540145
81	MAP2K7	0.45121655
82	PRKACA	0.43399481
83	PRKCQ	0.43290996
84	NEK2	0.42687889
85	PHKG1	0.42416621
86	PHKG2	0.42416621
87	RPS6KA5	0.42001516
88	MAP3K13	0.40997108
89	PRKD3	0.39689414
90	CSK	0.39510182
91	RPS6KA4	0.39116019
92	CASK	0.37842931
93	LYN	0.37488635
94	CAMK2D	0.37179756
95	OBSCN	0.36844153
96	EIF2AK2	0.36673042
97	MYLK	0.36542358
98	WNK1	0.36217158
99	PIK3CG	0.34651745
100	KIT	0.34606690

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.76508091
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.31496834
3	Parkinsons disease_Homo sapiens_hsa05012	3.49197918
4	Proteasome_Homo sapiens_hsa03050	2.83815698
5	RNA polymerase_Homo sapiens_hsa03020	2.61775864
6	Huntingtons disease_Homo sapiens_hsa05016	2.45108330
7	Protein export_Homo sapiens_hsa03060	2.42575361
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.35363738
9	Alzheimers disease_Homo sapiens_hsa05010	2.30110353
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.24641598
11	Asthma_Homo sapiens_hsa05310	2.17956142
12	Homologous recombination_Homo sapiens_hsa03440	2.05132586
13	One carbon pool by folate_Homo sapiens_hsa00670	1.99720095
14	RNA degradation_Homo sapiens_hsa03018	1.96932722
15	Mismatch repair_Homo sapiens_hsa03430	1.92513638
16	Sulfur relay system_Homo sapiens_hsa04122	1.83909668
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81348651
18	Allograft rejection_Homo sapiens_hsa05330	1.70844251
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.68509187
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.58262137
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.56837723
22	Caffeine metabolism_Homo sapiens_hsa00232	1.56484061
23	DNA replication_Homo sapiens_hsa03030	1.50726714
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.49251162
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.48553723
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.48139794
27	Basal transcription factors_Homo sapiens_hsa03022	1.46223904
28	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.42865519
29	Spliceosome_Homo sapiens_hsa03040	1.36074198
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.32645404
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26410860
32	Non-homologous end-joining_Homo sapiens_hsa03450	1.23109975
33	Phototransduction_Homo sapiens_hsa04744	1.20027486
34	RNA transport_Homo sapiens_hsa03013	1.16654378
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.15555913
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.15015195
37	Propanoate metabolism_Homo sapiens_hsa00640	1.13322760
38	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.08659568
39	Base excision repair_Homo sapiens_hsa03410	0.99705319
40	Peroxisome_Homo sapiens_hsa04146	0.99154614
41	Purine metabolism_Homo sapiens_hsa00230	0.96622398
42	Type I diabetes mellitus_Homo sapiens_hsa04940	0.90645148
43	Graft-versus-host disease_Homo sapiens_hsa05332	0.85645592
44	Nitrogen metabolism_Homo sapiens_hsa00910	0.85381003
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84552848
46	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.83219865
47	Folate biosynthesis_Homo sapiens_hsa00790	0.81179202
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.80844963
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.78144905
50	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.75292964
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.73348601
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.67736063
53	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.66724733
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66049748
55	Metabolic pathways_Homo sapiens_hsa01100	0.65322110
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.64855654
57	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63197519
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61526947
59	Rheumatoid arthritis_Homo sapiens_hsa05323	0.58429093
60	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.57740151
61	Fatty acid degradation_Homo sapiens_hsa00071	0.56886567
62	Retinol metabolism_Homo sapiens_hsa00830	0.55252641
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54023114
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.53052501
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.51633093
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50477857
67	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.48816088
68	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48559249
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47515167
70	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.47012105
71	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.46969664
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46257408
73	Nicotine addiction_Homo sapiens_hsa05033	0.46244989
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.45810344
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42478931
76	Pyruvate metabolism_Homo sapiens_hsa00620	0.40804386
77	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.39550050
78	Butanoate metabolism_Homo sapiens_hsa00650	0.39450506
79	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38622530
80	Regulation of autophagy_Homo sapiens_hsa04140	0.36156622
81	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.35803357
82	Sulfur metabolism_Homo sapiens_hsa00920	0.35350592
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.34216491
84	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.33284954
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33079988
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.29537082
87	Olfactory transduction_Homo sapiens_hsa04740	0.28926034
88	Taste transduction_Homo sapiens_hsa04742	0.27677976
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26362517
90	Antigen processing and presentation_Homo sapiens_hsa04612	0.24171189
91	Fatty acid elongation_Homo sapiens_hsa00062	0.22210466
92	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.22166394
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.21236579
94	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.19483303
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.16910843
96	Mineral absorption_Homo sapiens_hsa04978	0.15884991
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.15665816
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.15039895
99	Morphine addiction_Homo sapiens_hsa05032	0.14757251
100	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.14427820

RPL12P15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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