ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	9.90184124
2	viral transcription (GO:0019083)	8.40501195
3	translational termination (GO:0006415)	7.99658890
4	ribosomal small subunit biogenesis (GO:0042274)	7.01774202
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.80492747
6	translational elongation (GO:0006414)	6.74565292
7	cotranslational protein targeting to membrane (GO:0006613)	6.67960953
8	protein targeting to ER (GO:0045047)	6.60148791
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.28482857
10	protein localization to endoplasmic reticulum (GO:0070972)	6.26511206
11	cellular protein complex disassembly (GO:0043624)	6.02869163
12	viral life cycle (GO:0019058)	5.97314119
13	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.79464491
14	translational initiation (GO:0006413)	5.57069642
15	maturation of SSU-rRNA (GO:0030490)	5.21475182
16	protein complex disassembly (GO:0043241)	4.94523970
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.94253233
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.79851449
19	ATP synthesis coupled proton transport (GO:0015986)	4.79851449
20	macromolecular complex disassembly (GO:0032984)	4.72078294
21	ribosomal large subunit biogenesis (GO:0042273)	4.65455607
22	negative regulation of mast cell activation (GO:0033004)	4.64133017
23	protein targeting to membrane (GO:0006612)	4.22743679
24	translation (GO:0006412)	4.14879340
25	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.95329606
26	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.84845721
27	protein complex biogenesis (GO:0070271)	3.83757451
28	formation of translation preinitiation complex (GO:0001731)	3.78649286
29	regulation of activation of Janus kinase activity (GO:0010533)	3.75117357
30	mRNA catabolic process (GO:0006402)	3.72047035
31	behavioral response to nicotine (GO:0035095)	3.71066278
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.60555016
33	NADH dehydrogenase complex assembly (GO:0010257)	3.60555016
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.60555016
35	piRNA metabolic process (GO:0034587)	3.47282868
36	protein-cofactor linkage (GO:0018065)	3.47270381
37	peptidyl-histidine modification (GO:0018202)	3.36087163
38	positive regulation of prostaglandin secretion (GO:0032308)	3.36035249
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.30895199
40	forebrain morphogenesis (GO:0048853)	3.28563054
41	RNA catabolic process (GO:0006401)	3.28275250
42	ribonucleoprotein complex biogenesis (GO:0022613)	3.26692547
43	cellular component biogenesis (GO:0044085)	3.25211701
44	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.21561677
45	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.20686082
46	electron transport chain (GO:0022900)	3.15119162
47	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.14957937
48	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.14957937
49	respiratory electron transport chain (GO:0022904)	3.12950327
50	iron-sulfur cluster assembly (GO:0016226)	3.12423888
51	metallo-sulfur cluster assembly (GO:0031163)	3.12423888
52	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.09788704
53	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.03212163
54	GTP biosynthetic process (GO:0006183)	3.03071455
55	GPI anchor metabolic process (GO:0006505)	2.95587029
56	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.95566362
57	maturation of 5.8S rRNA (GO:0000460)	2.94115481
58	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.93515310
59	ATP biosynthetic process (GO:0006754)	2.93196332
60	platelet dense granule organization (GO:0060155)	2.93126930
61	ncRNA 3-end processing (GO:0043628)	2.92940358
62	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.91639210
63	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.90970231
64	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.90433202
65	establishment of protein localization to membrane (GO:0090150)	2.88441855
66	positive regulation of respiratory burst (GO:0060267)	2.88357263
67	autophagic vacuole fusion (GO:0000046)	2.88027816
68	ubiquinone biosynthetic process (GO:0006744)	2.87628716
69	GPI anchor biosynthetic process (GO:0006506)	2.85971830
70	mannosylation (GO:0097502)	2.85071406
71	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.84261039
72	oxidative phosphorylation (GO:0006119)	2.76806454
73	DNA deamination (GO:0045006)	2.71603091
74	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.69311342
75	positive regulation of icosanoid secretion (GO:0032305)	2.68097408
76	cytochrome complex assembly (GO:0017004)	2.66166212
77	chaperone-mediated protein transport (GO:0072321)	2.65720811
78	hydrogen ion transmembrane transport (GO:1902600)	2.63468840
79	rRNA processing (GO:0006364)	2.62563480
80	proton transport (GO:0015992)	2.58151853
81	preassembly of GPI anchor in ER membrane (GO:0016254)	2.57876318
82	otic vesicle formation (GO:0030916)	2.57820549
83	purine nucleotide salvage (GO:0032261)	2.56926967
84	rRNA metabolic process (GO:0016072)	2.56622549
85	protein targeting (GO:0006605)	2.55895406
86	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.55061036
87	hydrogen transport (GO:0006818)	2.54989798
88	establishment of protein localization to organelle (GO:0072594)	2.53022666
89	regulation of prostaglandin secretion (GO:0032306)	2.52767342
90	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.50475018
91	quinone biosynthetic process (GO:1901663)	2.48951805
92	positive regulation of fatty acid transport (GO:2000193)	2.47945352
93	termination of RNA polymerase III transcription (GO:0006386)	2.47784985
94	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.47784985
95	UTP biosynthetic process (GO:0006228)	2.47065348
96	pseudouridine synthesis (GO:0001522)	2.46910076
97	base-excision repair, AP site formation (GO:0006285)	2.46661178
98	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.46637467
99	ubiquinone metabolic process (GO:0006743)	2.43984925
100	protein polyglutamylation (GO:0018095)	2.43404405

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.91152402
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.59920860
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.37337527
4	VDR_22108803_ChIP-Seq_LS180_Human	3.09277345
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.84501825
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.78379568
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.44702628
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.13929594
9	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.08199282
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.05057242
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.98900036
12	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.87271927
13	ZNF274_21170338_ChIP-Seq_K562_Hela	1.82858301
14	IGF1R_20145208_ChIP-Seq_DFB_Human	1.81855828
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.80330082
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.80011445
17	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.73940008
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.73432175
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.70043348
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.68419334
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.67215938
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62197372
23	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.59712094
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.57136244
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.56286274
26	FUS_26573619_Chip-Seq_HEK293_Human	1.55722039
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.48539676
28	NCOR_22424771_ChIP-Seq_293T_Human	1.47099124
29	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.46226428
30	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.43981031
31	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43103194
32	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43103194
33	EWS_26573619_Chip-Seq_HEK293_Human	1.42393115
34	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.41726577
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.41391375
36	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.39901042
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.39796455
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38622027
39	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.38533562
40	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.37834977
41	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.36748419
42	AR_20517297_ChIP-Seq_VCAP_Human	1.36376306
43	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.35372547
44	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35044197
45	FOXP3_21729870_ChIP-Seq_TREG_Human	1.33896466
46	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.33149570
47	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.32603528
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.31217345
49	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.30438534
50	NANOG_20526341_ChIP-Seq_ESCs_Human	1.29958882
51	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.29443810
52	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.28217295
53	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27082127
54	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.25165650
55	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.24896586
56	TAF2_19829295_ChIP-Seq_ESCs_Human	1.23900691
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.22790144
58	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.21869749
59	TTF2_22483619_ChIP-Seq_HELA_Human	1.21782412
60	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.20989351
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20091670
62	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.18419616
63	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.16926359
64	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.16746966
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16375201
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.16375201
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15063129
68	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.14073446
69	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.13881393
70	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.13472887
71	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.12258997
72	CTCF_20526341_ChIP-Seq_ESCs_Human	1.10718322
73	P300_19829295_ChIP-Seq_ESCs_Human	1.09517777
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08922811
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08847632
76	ELK1_19687146_ChIP-ChIP_HELA_Human	1.08160118
77	ER_23166858_ChIP-Seq_MCF-7_Human	1.07936147
78	ERA_21632823_ChIP-Seq_H3396_Human	1.06729030
79	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.05618830
80	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.04784794
81	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.03056533
82	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.00454746
83	ERG_20517297_ChIP-Seq_VCAP_Human	1.00247277
84	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.00244939
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00185441
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99873775
87	P53_21459846_ChIP-Seq_SAOS-2_Human	0.98039446
88	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97373168
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96389931
90	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.96228760
91	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95993860
92	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.95746501
93	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.95539109
94	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95470413
95	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95470413
96	STAT1_20625510_ChIP-Seq_HELA_Human	0.94862084
97	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.93750235
98	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93346248
99	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.92758859
100	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.91792413

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.13389395
2	MP0006292_abnormal_olfactory_placode	4.70419667
3	MP0003646_muscle_fatigue	3.15116483
4	MP0005084_abnormal_gallbladder_morpholo	2.25064848
5	MP0002163_abnormal_gland_morphology	2.21952697
6	MP0004885_abnormal_endolymph	2.20002422
7	MP0003283_abnormal_digestive_organ	2.16742598
8	MP0010386_abnormal_urinary_bladder	2.07308455
9	MP0002876_abnormal_thyroid_physiology	1.97455130
10	MP0002160_abnormal_reproductive_system	1.94717061
11	MP0008872_abnormal_physiological_respon	1.93485602
12	MP0005645_abnormal_hypothalamus_physiol	1.90284683
13	MP0005646_abnormal_pituitary_gland	1.90229854
14	MP0002837_dystrophic_cardiac_calcinosis	1.84108114
15	MP0005671_abnormal_response_to	1.81159763
16	MP0008995_early_reproductive_senescence	1.71713171
17	MP0002095_abnormal_skin_pigmentation	1.67801458
18	MP0002277_abnormal_respiratory_mucosa	1.63473312
19	MP0008877_abnormal_DNA_methylation	1.56371704
20	MP0005174_abnormal_tail_pigmentation	1.55785236
21	MP0002938_white_spotting	1.55350681
22	MP0005551_abnormal_eye_electrophysiolog	1.52756066
23	MP0005389_reproductive_system_phenotype	1.51377899
24	MP0000372_irregular_coat_pigmentation	1.50784784
25	MP0004142_abnormal_muscle_tone	1.48389746
26	MP0004147_increased_porphyrin_level	1.46910977
27	MP0005075_abnormal_melanosome_morpholog	1.46823380
28	MP0002102_abnormal_ear_morphology	1.46741256
29	MP0005379_endocrine/exocrine_gland_phen	1.44927564
30	MP0001968_abnormal_touch/_nociception	1.43241877
31	MP0001188_hyperpigmentation	1.40862248
32	MP0001905_abnormal_dopamine_level	1.39882907
33	MP0002132_abnormal_respiratory_system	1.37986210
34	MP0002138_abnormal_hepatobiliary_system	1.35956635
35	MP0004145_abnormal_muscle_electrophysio	1.34111166
36	MP0003136_yellow_coat_color	1.32247309
37	MP0002653_abnormal_ependyma_morphology	1.30020680
38	MP0002234_abnormal_pharynx_morphology	1.28321150
39	MP0005410_abnormal_fertilization	1.26063222
40	MP0006276_abnormal_autonomic_nervous	1.24846049
41	MP0006072_abnormal_retinal_apoptosis	1.23983745
42	MP0000049_abnormal_middle_ear	1.23633120
43	MP0008789_abnormal_olfactory_epithelium	1.23177465
44	MP0001873_stomach_inflammation	1.21108285
45	MP0003195_calcinosis	1.20469082
46	MP0009333_abnormal_splenocyte_physiolog	1.19726797
47	MP0000631_abnormal_neuroendocrine_gland	1.18105646
48	MP0003186_abnormal_redox_activity	1.17174514
49	MP0001835_abnormal_antigen_presentation	1.13967985
50	MP0008875_abnormal_xenobiotic_pharmacok	1.13059384
51	MP0001485_abnormal_pinna_reflex	1.12448250
52	MP0000678_abnormal_parathyroid_gland	1.11942271
53	MP0001664_abnormal_digestion	1.11865304
54	MP0003880_abnormal_central_pattern	1.09036463
55	MP0002272_abnormal_nervous_system	1.06985982
56	MP0000566_synostosis	1.03574923
57	MP0009745_abnormal_behavioral_response	1.01973561
58	MP0001919_abnormal_reproductive_system	1.01766738
59	MP0002148_abnormal_hypersensitivity_rea	1.01021436
60	MP0001986_abnormal_taste_sensitivity	1.00354045
61	MP0002638_abnormal_pupillary_reflex	0.94343586
62	MP0002736_abnormal_nociception_after	0.94204321
63	MP0000639_abnormal_adrenal_gland	0.93857101
64	MP0000462_abnormal_digestive_system	0.92034260
65	MP0005253_abnormal_eye_physiology	0.90774794
66	MP0002210_abnormal_sex_determination	0.90336741
67	MP0001663_abnormal_digestive_system	0.90258533
68	MP0003567_abnormal_fetal_cardiomyocyte	0.90007227
69	MP0002735_abnormal_chemical_nociception	0.89168580
70	MP0008058_abnormal_DNA_repair	0.88965886
71	MP0005360_urolithiasis	0.88792066
72	MP0000026_abnormal_inner_ear	0.87559281
73	MP0009643_abnormal_urine_homeostasis	0.86683461
74	MP0000230_abnormal_systemic_arterial	0.85938396
75	MP0001963_abnormal_hearing_physiology	0.84097070
76	MP0002822_catalepsy	0.83591666
77	MP0002928_abnormal_bile_duct	0.81994377
78	MP0000653_abnormal_sex_gland	0.77690437
79	MP0001929_abnormal_gametogenesis	0.77529931
80	MP0001145_abnormal_male_reproductive	0.77400924
81	MP0003698_abnormal_male_reproductive	0.77069654
82	MP0005381_digestive/alimentary_phenotyp	0.77033473
83	MP0003943_abnormal_hepatobiliary_system	0.74422542
84	MP0001764_abnormal_homeostasis	0.74293739
85	MP0000681_abnormal_thyroid_gland	0.73971019
86	MP0005332_abnormal_amino_acid	0.73935106
87	MP0001661_extended_life_span	0.73630812
88	MP0005636_abnormal_mineral_homeostasis	0.73333260
89	MP0001970_abnormal_pain_threshold	0.72920858
90	MP0003806_abnormal_nucleotide_metabolis	0.72638787
91	MP0002733_abnormal_thermal_nociception	0.72584830
92	MP0009384_cardiac_valve_regurgitation	0.72248186
93	MP0006036_abnormal_mitochondrial_physio	0.71815238
94	MP0009785_altered_susceptibility_to	0.71446294
95	MP0000343_altered_response_to	0.71325584
96	MP0000538_abnormal_urinary_bladder	0.70486529
97	MP0005499_abnormal_olfactory_system	0.70368529
98	MP0005394_taste/olfaction_phenotype	0.70368529
99	MP0001324_abnormal_eye_pigmentation	0.70344448
100	MP0001800_abnormal_humoral_immune	0.69946813

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.64034504
2	Macrocytic anemia (HP:0001972)	3.80977588
3	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.68815551
4	3-Methylglutaconic aciduria (HP:0003535)	3.64347083
5	Abnormality of cells of the erythroid lineage (HP:0012130)	3.53680736
6	Acute necrotizing encephalopathy (HP:0006965)	3.49459132
7	Abnormal rod and cone electroretinograms (HP:0008323)	3.41974352
8	Congenital stationary night blindness (HP:0007642)	3.32834899
9	Mitochondrial inheritance (HP:0001427)	3.26013268
10	Stenosis of the external auditory canal (HP:0000402)	3.25456778
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.14429267
12	Attenuation of retinal blood vessels (HP:0007843)	3.08956279
13	Constricted visual fields (HP:0001133)	3.06330087
14	Pallor (HP:0000980)	3.03663436
15	Increased CSF lactate (HP:0002490)	3.02977028
16	Molar tooth sign on MRI (HP:0002419)	3.01241941
17	Abnormality of midbrain morphology (HP:0002418)	3.01241941
18	Absent/shortened dynein arms (HP:0200106)	2.98909813
19	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.98909813
20	Acute encephalopathy (HP:0006846)	2.88331398
21	Abolished electroretinogram (ERG) (HP:0000550)	2.84577504
22	Abnormal number of erythroid precursors (HP:0012131)	2.82972616
23	Progressive macrocephaly (HP:0004481)	2.81794243
24	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.62969330
25	Optic disc pallor (HP:0000543)	2.59919760
26	Hepatocellular necrosis (HP:0001404)	2.58573805
27	Nephronophthisis (HP:0000090)	2.52636885
28	Panhypogammaglobulinemia (HP:0003139)	2.52511832
29	Pancreatic cysts (HP:0001737)	2.51689409
30	Abnormality of B cell number (HP:0010975)	2.49927904
31	Dyschromatopsia (HP:0007641)	2.45094010
32	Abnormality of the renal collecting system (HP:0004742)	2.43113613
33	Hepatic necrosis (HP:0002605)	2.42438290
34	True hermaphroditism (HP:0010459)	2.37990306
35	Decreased central vision (HP:0007663)	2.36863777
36	Increased hepatocellular lipid droplets (HP:0006565)	2.35730321
37	Polydipsia (HP:0001959)	2.35305633
38	Abnormal drinking behavior (HP:0030082)	2.35305633
39	Asplenia (HP:0001746)	2.34811822
40	Colon cancer (HP:0003003)	2.33506725
41	Renal Fanconi syndrome (HP:0001994)	2.31750003
42	Maternal diabetes (HP:0009800)	2.30831995
43	Bile duct proliferation (HP:0001408)	2.26269042
44	Abnormal biliary tract physiology (HP:0012439)	2.26269042
45	Absent thumb (HP:0009777)	2.22204328
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.21127144
47	Polyuria (HP:0000103)	2.18983097
48	Septo-optic dysplasia (HP:0100842)	2.17535241
49	Elevated erythrocyte sedimentation rate (HP:0003565)	2.14734878
50	Abnormality of urine glucose concentration (HP:0011016)	2.12154050
51	Glycosuria (HP:0003076)	2.12154050
52	Lipid accumulation in hepatocytes (HP:0006561)	2.11935387
53	Increased serum lactate (HP:0002151)	2.10250442
54	Cerebral edema (HP:0002181)	2.08831858
55	Abnormal ciliary motility (HP:0012262)	2.07923778
56	Abnormality of macular pigmentation (HP:0008002)	2.06934152
57	B lymphocytopenia (HP:0010976)	2.06650655
58	Abnormal respiratory motile cilium morphology (HP:0005938)	2.06318822
59	Abnormal respiratory epithelium morphology (HP:0012253)	2.06318822
60	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.04556198
61	Rhinitis (HP:0012384)	2.04324742
62	Abnormality of the renal medulla (HP:0100957)	2.03809837
63	Severe visual impairment (HP:0001141)	2.02532917
64	Pancreatic fibrosis (HP:0100732)	2.00251304
65	Hyperglycinemia (HP:0002154)	1.98432096
66	Abnormality of renal excretion (HP:0011036)	1.97685145
67	Abnormal respiratory motile cilium physiology (HP:0012261)	1.96227169
68	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.95677604
69	Abnormality of renal resorption (HP:0011038)	1.94492103
70	Abnormal urine output (HP:0012590)	1.94346765
71	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.91382362
72	Hypoglycemic seizures (HP:0002173)	1.91012791
73	Severe combined immunodeficiency (HP:0004430)	1.90839486
74	Lethargy (HP:0001254)	1.90336562
75	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.88584042
76	Lactic acidosis (HP:0003128)	1.88488093
77	Abnormality of the renal cortex (HP:0011035)	1.88094613
78	Abnormality of DNA repair (HP:0003254)	1.87934587
79	Testicular atrophy (HP:0000029)	1.87699309
80	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.84099630
81	Malnutrition (HP:0004395)	1.83544590
82	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.78473477
83	Rib fusion (HP:0000902)	1.78101056
84	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.75762616
85	Abnormality of alanine metabolism (HP:0010916)	1.75762616
86	Hyperalaninemia (HP:0003348)	1.75762616
87	Abnormal protein glycosylation (HP:0012346)	1.75722698
88	Abnormal glycosylation (HP:0012345)	1.75722698
89	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.75722698
90	Abnormal protein N-linked glycosylation (HP:0012347)	1.75722698
91	Metaphyseal dysplasia (HP:0100255)	1.74142837
92	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.73041547
93	Increased intramyocellular lipid droplets (HP:0012240)	1.68703520
94	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.67428054
95	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.67428054
96	Male pseudohermaphroditism (HP:0000037)	1.67016654
97	Cystic liver disease (HP:0006706)	1.66548118
98	Sclerocornea (HP:0000647)	1.64712113
99	IgG deficiency (HP:0004315)	1.63571163
100	Hypomagnesemia (HP:0002917)	1.61258690

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	2.92373297
2	CDK19	2.73543479
3	TXK	2.51003686
4	ADRBK2	2.48575576
5	WNK4	2.39884659
6	PASK	2.38122964
7	MAP4K1	2.25490941
8	MAP4K2	2.20105748
9	MAP3K12	2.00373141
10	LIMK1	1.97419116
11	NUAK1	1.94619873
12	GRK1	1.83391759
13	STK39	1.76220373
14	MAP3K11	1.71439088
15	BMPR1B	1.71422529
16	CDK8	1.70256166
17	TIE1	1.69953642
18	PINK1	1.62977109
19	KDR	1.59928654
20	KIT	1.55774317
21	STK16	1.53664366
22	CAMKK2	1.49323197
23	BCKDK	1.46356220
24	INSRR	1.43799664
25	ACVR1B	1.40356214
26	FRK	1.39772531
27	DYRK2	1.39242917
28	ADRBK1	1.30535328
29	WNK3	1.28974930
30	TAF1	1.25672001
31	OXSR1	1.25230733
32	PRKD3	1.23012193
33	EPHB2	1.19679158
34	TEC	1.14941037
35	ABL2	1.13900848
36	PRKCQ	1.12356571
37	MUSK	1.10901595
38	RPS6KB2	1.09294944
39	CDK3	1.09171297
40	NME2	1.05351877
41	MAPK13	1.04405056
42	VRK1	1.01143273
43	FLT3	1.00512748
44	PRKCH	0.99442472
45	TLK1	0.96896801
46	MAPK7	0.96399900
47	CAMKK1	0.96202507
48	BMPR2	0.95982809
49	MATK	0.95302045
50	PLK4	0.94188474
51	DAPK3	0.94018674
52	TGFBR1	0.93791546
53	ZAK	0.93350196
54	MAPKAPK5	0.92905580
55	TAOK3	0.92708476
56	PRKCE	0.89067860
57	PRKCI	0.87032063
58	MAP3K4	0.86339575
59	SYK	0.85631319
60	IRAK4	0.85270600
61	LRRK2	0.84715884
62	NLK	0.84295968
63	PBK	0.82712684
64	LMTK2	0.80682657
65	MAP2K4	0.73933227
66	PIK3CA	0.72708580
67	TESK2	0.72500631
68	DAPK2	0.70553018
69	CLK1	0.69599078
70	LCK	0.68714245
71	PRKCD	0.67883793
72	CCNB1	0.67745786
73	PRKCG	0.67146762
74	BRSK1	0.66085112
75	CAMK1	0.65739292
76	DAPK1	0.65591478
77	PRKG2	0.64176090
78	CSNK2A2	0.63210015
79	ILK	0.62038310
80	OBSCN	0.60678959
81	IKBKB	0.59591577
82	MST4	0.58749946
83	PRKACA	0.57653130
84	GRK5	0.55019398
85	RPS6KA5	0.53560456
86	BTK	0.53442019
87	PDK2	0.53289287
88	PRKCA	0.51707484
89	PRKG1	0.51230512
90	MAP2K6	0.50746627
91	ITK	0.50378744
92	CSNK2A1	0.49936566
93	PHKG2	0.48641061
94	PHKG1	0.48641061
95	LYN	0.48450771
96	MAP2K7	0.48378202
97	CSNK1G1	0.46379440
98	RPS6KA6	0.46367635
99	PIK3CG	0.45222610
100	RPS6KA1	0.40570465

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.43753862
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.64954731
3	Parkinsons disease_Homo sapiens_hsa05012	2.93968238
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.43244298
5	Sulfur relay system_Homo sapiens_hsa04122	2.41237582
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.27432566
7	RNA polymerase_Homo sapiens_hsa03020	2.15736104
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.14117619
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.12759649
10	Proteasome_Homo sapiens_hsa03050	1.99726144
11	Primary immunodeficiency_Homo sapiens_hsa05340	1.94054823
12	Huntingtons disease_Homo sapiens_hsa05016	1.93827129
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.89156386
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.84361985
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.82335747
16	Alzheimers disease_Homo sapiens_hsa05010	1.79700737
17	Allograft rejection_Homo sapiens_hsa05330	1.52496388
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.50224362
19	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.48906159
20	Graft-versus-host disease_Homo sapiens_hsa05332	1.47196452
21	Regulation of autophagy_Homo sapiens_hsa04140	1.46897375
22	Butanoate metabolism_Homo sapiens_hsa00650	1.43389397
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.40914417
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.38951818
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.37597294
26	Fat digestion and absorption_Homo sapiens_hsa04975	1.36519815
27	RNA degradation_Homo sapiens_hsa03018	1.36446206
28	Protein export_Homo sapiens_hsa03060	1.31560168
29	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.27859132
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.26748276
31	Phototransduction_Homo sapiens_hsa04744	1.25087861
32	Asthma_Homo sapiens_hsa05310	1.24997326
33	Peroxisome_Homo sapiens_hsa04146	1.21915045
34	Homologous recombination_Homo sapiens_hsa03440	1.19998372
35	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.19251209
36	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.18991708
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.15106833
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14368539
39	Olfactory transduction_Homo sapiens_hsa04740	1.13600383
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12903624
41	Nitrogen metabolism_Homo sapiens_hsa00910	1.09919527
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05127015
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02407794
44	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.00058240
45	Retinol metabolism_Homo sapiens_hsa00830	0.99501371
46	Rheumatoid arthritis_Homo sapiens_hsa05323	0.99422883
47	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91750854
48	Antigen processing and presentation_Homo sapiens_hsa04612	0.91196816
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90200918
50	Purine metabolism_Homo sapiens_hsa00230	0.88152184
51	Caffeine metabolism_Homo sapiens_hsa00232	0.80888269
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79922740
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.78481947
54	Fanconi anemia pathway_Homo sapiens_hsa03460	0.78083738
55	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.76640385
56	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.74859527
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72936816
58	Sulfur metabolism_Homo sapiens_hsa00920	0.72420086
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.71120863
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71090443
61	Tyrosine metabolism_Homo sapiens_hsa00350	0.70489219
62	Basal transcription factors_Homo sapiens_hsa03022	0.70393387
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.69301712
64	Nicotine addiction_Homo sapiens_hsa05033	0.69261038
65	Metabolic pathways_Homo sapiens_hsa01100	0.68000290
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62108130
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60255918
68	Glutathione metabolism_Homo sapiens_hsa00480	0.58213287
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56321629
70	Taste transduction_Homo sapiens_hsa04742	0.56230433
71	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.56153445
72	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.54809943
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.54092283
74	African trypanosomiasis_Homo sapiens_hsa05143	0.53470958
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53399104
76	Malaria_Homo sapiens_hsa05144	0.53120865
77	Nucleotide excision repair_Homo sapiens_hsa03420	0.52670614
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.52250188
79	Salivary secretion_Homo sapiens_hsa04970	0.50392772
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.49462866
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.49200457
82	Pancreatic secretion_Homo sapiens_hsa04972	0.47618857
83	Propanoate metabolism_Homo sapiens_hsa00640	0.47529090
84	Base excision repair_Homo sapiens_hsa03410	0.46594164
85	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.45422023
86	Mineral absorption_Homo sapiens_hsa04978	0.43764881
87	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.40253319
88	Mismatch repair_Homo sapiens_hsa03430	0.39350824
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.38434948
90	DNA replication_Homo sapiens_hsa03030	0.37533585
91	RNA transport_Homo sapiens_hsa03013	0.35161524
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33840108
93	Insulin secretion_Homo sapiens_hsa04911	0.33805717
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33503473
95	Morphine addiction_Homo sapiens_hsa05032	0.31022190
96	Spliceosome_Homo sapiens_hsa03040	0.28286010
97	Circadian entrainment_Homo sapiens_hsa04713	0.27782561
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.25611383
99	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.25012302
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.24554074

RPL12P16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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