ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.99257612
2	ribosomal small subunit assembly (GO:0000028)	7.89823469
3	ribosomal small subunit biogenesis (GO:0042274)	7.72696638
4	translational termination (GO:0006415)	7.69400858
5	maturation of SSU-rRNA (GO:0030490)	7.13211033
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.66373141
7	cotranslational protein targeting to membrane (GO:0006613)	6.58424218
8	protein targeting to ER (GO:0045047)	6.52192910
9	translational elongation (GO:0006414)	6.49051153
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.27651472
11	protein localization to endoplasmic reticulum (GO:0070972)	6.20656089
12	viral life cycle (GO:0019058)	5.72707761
13	cellular protein complex disassembly (GO:0043624)	5.71712814
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.69398120
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.41106707
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.29225207
17	ATP synthesis coupled proton transport (GO:0015986)	5.29225207
18	translational initiation (GO:0006413)	5.23235636
19	DNA deamination (GO:0045006)	5.16800188
20	ribosomal large subunit biogenesis (GO:0042273)	5.03951102
21	chaperone-mediated protein transport (GO:0072321)	4.86310009
22	protein complex disassembly (GO:0043241)	4.81334879
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.56719589
24	macromolecular complex disassembly (GO:0032984)	4.53983511
25	translation (GO:0006412)	4.47281469
26	ribonucleoprotein complex biogenesis (GO:0022613)	4.44367550
27	protein targeting to membrane (GO:0006612)	4.43141707
28	cellular component biogenesis (GO:0044085)	4.25811083
29	protein complex biogenesis (GO:0070271)	4.22384445
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.19919184
31	NADH dehydrogenase complex assembly (GO:0010257)	4.19919184
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.19919184
33	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.17037335
34	GTP biosynthetic process (GO:0006183)	4.01919874
35	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.00640692
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.00640692
37	mRNA catabolic process (GO:0006402)	3.96956354
38	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.93383996
39	substrate-independent telencephalic tangential migration (GO:0021826)	3.82913431
40	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.82913431
41	mitochondrial respiratory chain complex assembly (GO:0033108)	3.79460170
42	protein neddylation (GO:0045116)	3.65959567
43	RNA catabolic process (GO:0006401)	3.55630065
44	UTP biosynthetic process (GO:0006228)	3.53312170
45	UTP metabolic process (GO:0046051)	3.52521822
46	respiratory electron transport chain (GO:0022904)	3.51731421
47	electron transport chain (GO:0022900)	3.49517345
48	rRNA processing (GO:0006364)	3.48880736
49	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.43691634
50	rRNA metabolic process (GO:0016072)	3.41848327
51	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.36953431
52	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.35490547
53	somite development (GO:0061053)	3.34215696
54	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.28548619
55	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.25914305
56	water-soluble vitamin biosynthetic process (GO:0042364)	3.24472416
57	nonmotile primary cilium assembly (GO:0035058)	3.21414835
58	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.18781236
59	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.17389193
60	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.16674273
61	positive regulation of T cell apoptotic process (GO:0070234)	3.14515225
62	ATP biosynthetic process (GO:0006754)	3.14512865
63	ribosome biogenesis (GO:0042254)	3.12387857
64	intracellular protein transmembrane import (GO:0044743)	3.09780448
65	CTP biosynthetic process (GO:0006241)	3.05907229
66	CTP metabolic process (GO:0046036)	3.05907229
67	protein-cofactor linkage (GO:0018065)	3.05574945
68	establishment of protein localization to membrane (GO:0090150)	3.02324064
69	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.02177348
70	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.01187577
71	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.97145105
72	protein targeting (GO:0006605)	2.96748089
73	behavioral response to nicotine (GO:0035095)	2.91633178
74	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.89247092
75	tongue development (GO:0043586)	2.89212013
76	preassembly of GPI anchor in ER membrane (GO:0016254)	2.85895973
77	positive regulation of respiratory burst (GO:0060267)	2.85229737
78	respiratory chain complex IV assembly (GO:0008535)	2.83913568
79	tRNA processing (GO:0008033)	2.83262275
80	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.82036681
81	establishment of protein localization to organelle (GO:0072594)	2.79717486
82	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.79615259
83	cytochrome complex assembly (GO:0017004)	2.76454735
84	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.76135701
85	cytidine metabolic process (GO:0046087)	2.74232219
86	cytidine catabolic process (GO:0006216)	2.74232219
87	cytidine deamination (GO:0009972)	2.74232219
88	hydrogen ion transmembrane transport (GO:1902600)	2.71479746
89	ncRNA processing (GO:0034470)	2.71351935
90	rRNA modification (GO:0000154)	2.71281117
91	protein targeting to mitochondrion (GO:0006626)	2.68821585
92	neuron fate determination (GO:0048664)	2.68756837
93	pyrimidine nucleotide catabolic process (GO:0006244)	2.66788000
94	inner mitochondrial membrane organization (GO:0007007)	2.65748676
95	establishment of protein localization to mitochondrion (GO:0072655)	2.65498395
96	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.65254916
97	nucleoside triphosphate biosynthetic process (GO:0009142)	2.65010875
98	base-excision repair, AP site formation (GO:0006285)	2.59736490
99	DNA damage response, detection of DNA damage (GO:0042769)	2.58299777
100	pseudouridine synthesis (GO:0001522)	2.56830932

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.71170973
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.50579561
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.48910952
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.42029213
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.82031232
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.38379082
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.24812458
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.16736602
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.15981538
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.14793855
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.61339353
12	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.60898207
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.60355267
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.40964386
15	VDR_22108803_ChIP-Seq_LS180_Human	2.33776026
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.28667914
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.28028494
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.22705753
19	IRF1_19129219_ChIP-ChIP_H3396_Human	2.16050936
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.14883518
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.12491985
22	TTF2_22483619_ChIP-Seq_HELA_Human	2.08203029
23	MYC_18940864_ChIP-ChIP_HL60_Human	2.01717863
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.94280975
25	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.90076677
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.88969475
27	XRN2_22483619_ChIP-Seq_HELA_Human	1.80132489
28	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.78657786
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.63839625
30	GABP_19822575_ChIP-Seq_HepG2_Human	1.57001878
31	EWS_26573619_Chip-Seq_HEK293_Human	1.56192392
32	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.55854288
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.54721924
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.54269397
35	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.49959084
36	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.46239854
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45249048
38	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.40662710
39	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.40302452
40	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.33283610
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.29517956
42	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.26772375
43	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.24215957
44	IGF1R_20145208_ChIP-Seq_DFB_Human	1.23042485
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20939862
46	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.19777724
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19375787
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19375787
49	TAF2_19829295_ChIP-Seq_ESCs_Human	1.19086642
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.17301831
51	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.15734661
52	FUS_26573619_Chip-Seq_HEK293_Human	1.15717919
53	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.14471600
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14420370
55	DCP1A_22483619_ChIP-Seq_HELA_Human	1.13925812
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10099191
57	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.08225314
58	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.07654513
59	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07117427
60	ERA_21632823_ChIP-Seq_H3396_Human	1.06946761
61	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.06634930
62	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06318888
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05597911
64	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.05028848
65	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.04120571
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03666755
67	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.03389193
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02653758
69	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.01564922
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01384041
71	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00578841
72	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.00109984
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99887560
74	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99341616
75	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.98648416
76	NCOR_22424771_ChIP-Seq_293T_Human	0.97851001
77	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.97067857
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96931659
79	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.96152695
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95146780
81	AR_20517297_ChIP-Seq_VCAP_Human	0.94929864
82	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.92442514
83	KDM5A_27292631_Chip-Seq_BREAST_Human	0.91344542
84	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.91321492
85	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.90943729
86	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.89932293
87	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.89876750
88	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.89043602
89	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.88448705
90	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.84788018
91	MYC_19829295_ChIP-Seq_ESCs_Human	0.84620055
92	ERG_20517297_ChIP-Seq_VCAP_Human	0.84507025
93	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.82131932
94	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.81789073
95	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.81763236
96	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.81712514
97	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.81015103
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.80878801
99	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.79949161
100	P300_19829295_ChIP-Seq_ESCs_Human	0.78516688

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.11368881
2	MP0006292_abnormal_olfactory_placode	5.62801300
3	MP0002102_abnormal_ear_morphology	2.90728184
4	MP0004147_increased_porphyrin_level	2.65858730
5	MP0002163_abnormal_gland_morphology	2.63228730
6	MP0002653_abnormal_ependyma_morphology	2.55489064
7	MP0002638_abnormal_pupillary_reflex	2.47415981
8	MP0001293_anophthalmia	2.43667529
9	MP0008877_abnormal_DNA_methylation	2.37385072
10	MP0008789_abnormal_olfactory_epithelium	2.32074566
11	MP0003787_abnormal_imprinting	2.31184300
12	MP0000569_abnormal_digit_pigmentation	2.09011017
13	MP0003806_abnormal_nucleotide_metabolis	2.00337942
14	MP0005499_abnormal_olfactory_system	1.88843290
15	MP0005394_taste/olfaction_phenotype	1.88843290
16	MP0003011_delayed_dark_adaptation	1.80137548
17	MP0003646_muscle_fatigue	1.79420326
18	MP0002938_white_spotting	1.75169824
19	MP0002837_dystrophic_cardiac_calcinosis	1.74039532
20	MP0002234_abnormal_pharynx_morphology	1.72530851
21	MP0004142_abnormal_muscle_tone	1.65031238
22	MP0002736_abnormal_nociception_after	1.62231988
23	MP0004145_abnormal_muscle_electrophysio	1.61827431
24	MP0008875_abnormal_xenobiotic_pharmacok	1.56060723
25	MP0005551_abnormal_eye_electrophysiolog	1.52280165
26	MP0008872_abnormal_physiological_respon	1.50038400
27	MP0005379_endocrine/exocrine_gland_phen	1.48400089
28	MP0005377_hearing/vestibular/ear_phenot	1.46477251
29	MP0003878_abnormal_ear_physiology	1.46477251
30	MP0001968_abnormal_touch/_nociception	1.42942030
31	MP0008058_abnormal_DNA_repair	1.42447065
32	MP0004885_abnormal_endolymph	1.42431322
33	MP0005084_abnormal_gallbladder_morpholo	1.34853681
34	MP0000049_abnormal_middle_ear	1.33490147
35	MP0003786_premature_aging	1.32555500
36	MP0002095_abnormal_skin_pigmentation	1.32510964
37	MP0002138_abnormal_hepatobiliary_system	1.31461646
38	MP0003136_yellow_coat_color	1.30576969
39	MP0008995_early_reproductive_senescence	1.28824593
40	MP0005174_abnormal_tail_pigmentation	1.27183106
41	MP0006072_abnormal_retinal_apoptosis	1.26566133
42	MP0010030_abnormal_orbit_morphology	1.26507759
43	MP0006276_abnormal_autonomic_nervous	1.20551876
44	MP0004133_heterotaxia	1.18955628
45	MP0003186_abnormal_redox_activity	1.16094374
46	MP0000631_abnormal_neuroendocrine_gland	1.14183193
47	MP0001905_abnormal_dopamine_level	1.11977579
48	MP0001835_abnormal_antigen_presentation	1.11157273
49	MP0003718_maternal_effect	1.10148686
50	MP0005195_abnormal_posterior_eye	1.09006496
51	MP0000427_abnormal_hair_cycle	1.07760299
52	MP0001502_abnormal_circadian_rhythm	1.07429473
53	MP0004742_abnormal_vestibular_system	1.06966128
54	MP0001485_abnormal_pinna_reflex	1.03679988
55	MP0003121_genomic_imprinting	1.03547700
56	MP0005645_abnormal_hypothalamus_physiol	1.01541798
57	MP0002277_abnormal_respiratory_mucosa	1.01253276
58	MP0001501_abnormal_sleep_pattern	0.99029432
59	MP0000372_irregular_coat_pigmentation	0.98489942
60	MP0005389_reproductive_system_phenotype	0.98018514
61	MP0001986_abnormal_taste_sensitivity	0.96732612
62	MP0002557_abnormal_social/conspecific_i	0.96515604
63	MP0002160_abnormal_reproductive_system	0.95001699
64	MP0005646_abnormal_pituitary_gland	0.94058306
65	MP0002272_abnormal_nervous_system	0.93494294
66	MP0003567_abnormal_fetal_cardiomyocyte	0.92811626
67	MP0002752_abnormal_somatic_nervous	0.92618647
68	MP0008775_abnormal_heart_ventricle	0.92060950
69	MP0002210_abnormal_sex_determination	0.91203439
70	MP0000026_abnormal_inner_ear	0.89565930
71	MP0002184_abnormal_innervation	0.88439139
72	MP0001529_abnormal_vocalization	0.87200635
73	MP0003938_abnormal_ear_development	0.84865165
74	MP0003122_maternal_imprinting	0.84595331
75	MP0002233_abnormal_nose_morphology	0.83116394
76	MP0001873_stomach_inflammation	0.82892750
77	MP0001919_abnormal_reproductive_system	0.81965902
78	MP0001286_abnormal_eye_development	0.80574737
79	MP0002733_abnormal_thermal_nociception	0.78059014
80	MP0009745_abnormal_behavioral_response	0.77789549
81	MP0000685_abnormal_immune_system	0.77760767
82	MP0000955_abnormal_spinal_cord	0.77484051
83	MP0003123_paternal_imprinting	0.77196527
84	MP0002876_abnormal_thyroid_physiology	0.76687629
85	MP0005636_abnormal_mineral_homeostasis	0.76440874
86	MP0003283_abnormal_digestive_organ	0.76415465
87	MP0000778_abnormal_nervous_system	0.75995085
88	MP0004019_abnormal_vitamin_homeostasis	0.75388672
89	MP0003195_calcinosis	0.73870455
90	MP0001970_abnormal_pain_threshold	0.72790442
91	MP0005075_abnormal_melanosome_morpholog	0.72233061
92	MP0001963_abnormal_hearing_physiology	0.70158483
93	MP0003936_abnormal_reproductive_system	0.68770936
94	MP0003937_abnormal_limbs/digits/tail_de	0.68387671
95	MP0001984_abnormal_olfaction	0.67842195
96	MP0009333_abnormal_splenocyte_physiolog	0.66369724
97	MP0005391_vision/eye_phenotype	0.64016326
98	MP0002693_abnormal_pancreas_physiology	0.63859207
99	MP0001324_abnormal_eye_pigmentation	0.63707975
100	MP0000613_abnormal_salivary_gland	0.63680678

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.35426780
2	Acute necrotizing encephalopathy (HP:0006965)	4.93435418
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.80877615
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.35705849
5	Abnormality of midbrain morphology (HP:0002418)	4.34465770
6	Molar tooth sign on MRI (HP:0002419)	4.34465770
7	Acute encephalopathy (HP:0006846)	4.12915679
8	Progressive macrocephaly (HP:0004481)	4.10613934
9	Mitochondrial inheritance (HP:0001427)	4.05884561
10	Pancreatic fibrosis (HP:0100732)	3.70038644
11	Macrocytic anemia (HP:0001972)	3.67899748
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.67625641
13	Abnormal number of erythroid precursors (HP:0012131)	3.61010925
14	Increased CSF lactate (HP:0002490)	3.53717475
15	Pancreatic cysts (HP:0001737)	3.41229159
16	Nephronophthisis (HP:0000090)	3.32102219
17	Hepatocellular necrosis (HP:0001404)	3.30979019
18	Pallor (HP:0000980)	3.17633969
19	Cerebral edema (HP:0002181)	3.13939824
20	Hepatic necrosis (HP:0002605)	3.12227196
21	Increased hepatocellular lipid droplets (HP:0006565)	3.10061905
22	Abnormal rod and cone electroretinograms (HP:0008323)	3.06900162
23	Colon cancer (HP:0003003)	3.05642236
24	Lipid accumulation in hepatocytes (HP:0006561)	2.98343189
25	Septo-optic dysplasia (HP:0100842)	2.94499395
26	Optic disc pallor (HP:0000543)	2.88092908
27	Congenital stationary night blindness (HP:0007642)	2.82434298
28	3-Methylglutaconic aciduria (HP:0003535)	2.72850060
29	True hermaphroditism (HP:0010459)	2.71693553
30	Renal Fanconi syndrome (HP:0001994)	2.62130021
31	Abnormality of the renal medulla (HP:0100957)	2.60129642
32	Asplenia (HP:0001746)	2.56088536
33	Pendular nystagmus (HP:0012043)	2.49750466
34	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.48296985
35	Increased intramyocellular lipid droplets (HP:0012240)	2.47971118
36	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.47116451
37	Tubular atrophy (HP:0000092)	2.45337760
38	Leukodystrophy (HP:0002415)	2.41937002
39	Absent thumb (HP:0009777)	2.41336425
40	Stenosis of the external auditory canal (HP:0000402)	2.40489113
41	Abnormality of alanine metabolism (HP:0010916)	2.38134248
42	Hyperalaninemia (HP:0003348)	2.38134248
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.38134248
44	Increased serum lactate (HP:0002151)	2.37390333
45	Constricted visual fields (HP:0001133)	2.36874110
46	Cystic liver disease (HP:0006706)	2.34438803
47	Congenital, generalized hypertrichosis (HP:0004540)	2.33432033
48	Supernumerary spleens (HP:0009799)	2.28913134
49	Polydipsia (HP:0001959)	2.26083883
50	Abnormal drinking behavior (HP:0030082)	2.26083883
51	Depressed nasal ridge (HP:0000457)	2.25719311
52	Lactic acidosis (HP:0003128)	2.21550756
53	Exercise intolerance (HP:0003546)	2.19967037
54	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.19431433
55	Abnormality of the labia minora (HP:0012880)	2.17874840
56	Medial flaring of the eyebrow (HP:0010747)	2.16236775
57	Abnormality of the renal cortex (HP:0011035)	2.13755788
58	Oligodactyly (hands) (HP:0001180)	2.12869222
59	Anencephaly (HP:0002323)	2.12026926
60	Type II lissencephaly (HP:0007260)	2.09829391
61	Stomatitis (HP:0010280)	2.08517119
62	Increased muscle lipid content (HP:0009058)	2.07401377
63	Abolished electroretinogram (ERG) (HP:0000550)	2.06782889
64	Sclerocornea (HP:0000647)	2.05714488
65	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.05094312
66	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.05094312
67	Hypoplasia of the radius (HP:0002984)	2.02116796
68	Congenital hepatic fibrosis (HP:0002612)	2.00801328
69	Respiratory failure (HP:0002878)	1.99997437
70	Postaxial foot polydactyly (HP:0001830)	1.98177298
71	Exertional dyspnea (HP:0002875)	1.95070140
72	Hypoplasia of the ulna (HP:0003022)	1.94622077
73	Optic nerve hypoplasia (HP:0000609)	1.94416073
74	Lethargy (HP:0001254)	1.93168780
75	Glycosuria (HP:0003076)	1.93124025
76	Abnormality of urine glucose concentration (HP:0011016)	1.93124025
77	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.90338367
78	Hypomagnesemia (HP:0002917)	1.89650693
79	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.86628215
80	Oligodactyly (HP:0012165)	1.84956837
81	Hyperphosphaturia (HP:0003109)	1.84663324
82	Hypoplasia of the pons (HP:0012110)	1.84303449
83	Abnormal ciliary motility (HP:0012262)	1.83601895
84	Maternal diabetes (HP:0009800)	1.80869706
85	Abnormal respiratory motile cilium morphology (HP:0005938)	1.80352045
86	Abnormal respiratory epithelium morphology (HP:0012253)	1.80352045
87	Optic nerve coloboma (HP:0000588)	1.78498587
88	Abnormality of renal resorption (HP:0011038)	1.77714056
89	Abnormality of the pons (HP:0007361)	1.74891332
90	Abnormality of magnesium homeostasis (HP:0004921)	1.74637242
91	Chronic hepatic failure (HP:0100626)	1.73438262
92	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.72262552
93	Forearm undergrowth (HP:0009821)	1.70797124
94	Hyperglycinemia (HP:0002154)	1.69333894
95	Polyuria (HP:0000103)	1.69219036
96	Elevated erythrocyte sedimentation rate (HP:0003565)	1.67872078
97	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.66490074
98	Increased IgM level (HP:0003496)	1.65571195
99	Dyschromatopsia (HP:0007641)	1.65348750
100	Male pseudohermaphroditism (HP:0000037)	1.64343766

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	4.48387676
2	STK39	3.31712855
3	BCKDK	2.85581908
4	VRK2	2.61823242
5	NUAK1	2.57115254
6	ADRBK2	2.37586531
7	TLK1	2.34817438
8	CDK19	2.32007246
9	NEK1	2.26309339
10	ZAK	2.25539671
11	GRK1	2.25193417
12	TXK	2.12761847
13	TAF1	2.04437604
14	NME2	1.98609985
15	CDC7	1.89767331
16	PIK3CA	1.89607205
17	FRK	1.85866374
18	STK16	1.80162319
19	DYRK2	1.79787509
20	LRRK2	1.67839578
21	PASK	1.63708883
22	OXSR1	1.56883311
23	VRK1	1.48241364
24	MAP2K6	1.42903773
25	NME1	1.37252506
26	TAOK3	1.33780936
27	BMPR1B	1.26848716
28	EIF2AK1	1.25722420
29	TIE1	1.22056805
30	MAP4K1	1.14637787
31	MAP4K2	1.10535943
32	PINK1	1.07229540
33	EPHB2	1.02504484
34	PRKCQ	0.98841870
35	NTRK2	0.97031270
36	PRKCG	0.96985295
37	BUB1	0.95684761
38	IKBKB	0.95137531
39	WNK1	0.91767194
40	DAPK3	0.90180583
41	CAMK1	0.88525127
42	INSRR	0.88206288
43	CASK	0.87778871
44	TGFBR1	0.87522265
45	AURKB	0.84428902
46	MAP3K11	0.83721255
47	EPHA4	0.83254440
48	NTRK3	0.83082878
49	BRAF	0.80580740
50	PLK1	0.78845040
51	AURKA	0.78453450
52	PLK3	0.78121845
53	MST4	0.77035008
54	MAP3K4	0.76712143
55	NEK2	0.76023834
56	RPS6KB2	0.73982091
57	CSNK2A2	0.68690595
58	MAP3K13	0.67932761
59	ADRBK1	0.67759762
60	WNK3	0.67080611
61	PHKG2	0.65412368
62	PHKG1	0.65412368
63	MAP2K7	0.64553608
64	TEC	0.63872935
65	PIK3CG	0.60869653
66	ATR	0.60028679
67	TSSK6	0.58077124
68	RPS6KA6	0.56403414
69	FLT3	0.56093955
70	ARAF	0.55785072
71	MAP3K9	0.55347369
72	DMPK	0.54234510
73	CSNK1E	0.51392995
74	CSNK1G2	0.48399814
75	MAPKAPK5	0.48033456
76	EIF2AK3	0.47678491
77	TYRO3	0.47238528
78	ALK	0.46224243
79	PRKACA	0.45672284
80	RPS6KA5	0.45338836
81	CSNK2A1	0.44183959
82	MAP2K4	0.43861580
83	ITK	0.41610548
84	MKNK2	0.41581219
85	DYRK3	0.41561392
86	PRKCH	0.40184375
87	CAMKK2	0.40075360
88	CHEK2	0.39664804
89	CHEK1	0.38769367
90	PRKCD	0.38611030
91	PAK3	0.37879911
92	OBSCN	0.37269598
93	PDK2	0.36894773
94	SRPK1	0.36225147
95	GRK5	0.35409511
96	STK11	0.35190905
97	RPS6KC1	0.35179246
98	RPS6KL1	0.35179246
99	CAMK2A	0.34261752
100	CSNK1G1	0.32439382

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.82347994
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.02150301
3	Parkinsons disease_Homo sapiens_hsa05012	3.31093903
4	Protein export_Homo sapiens_hsa03060	2.82214332
5	Proteasome_Homo sapiens_hsa03050	2.78999910
6	RNA polymerase_Homo sapiens_hsa03020	2.56191973
7	Huntingtons disease_Homo sapiens_hsa05016	2.41725588
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.33948551
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.21634301
10	Alzheimers disease_Homo sapiens_hsa05010	2.19975277
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.12808424
12	Basal transcription factors_Homo sapiens_hsa03022	2.09148555
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.06450642
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.00296090
15	RNA degradation_Homo sapiens_hsa03018	1.95918248
16	Homologous recombination_Homo sapiens_hsa03440	1.93911794
17	One carbon pool by folate_Homo sapiens_hsa00670	1.84238982
18	Asthma_Homo sapiens_hsa05310	1.76181448
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.71844489
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.69175899
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.65323972
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55061696
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.42902612
24	Sulfur relay system_Homo sapiens_hsa04122	1.35482898
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.30841771
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.29059625
27	Base excision repair_Homo sapiens_hsa03410	1.28781924
28	Butanoate metabolism_Homo sapiens_hsa00650	1.20530148
29	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.20363884
30	Propanoate metabolism_Homo sapiens_hsa00640	1.17944699
31	Allograft rejection_Homo sapiens_hsa05330	1.16777065
32	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.13686034
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.12700321
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.10525746
35	Mismatch repair_Homo sapiens_hsa03430	1.09832146
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.09564331
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.07375299
38	Peroxisome_Homo sapiens_hsa04146	1.05137843
39	Primary immunodeficiency_Homo sapiens_hsa05340	1.00791500
40	Type I diabetes mellitus_Homo sapiens_hsa04940	0.96859403
41	RNA transport_Homo sapiens_hsa03013	0.95001902
42	DNA replication_Homo sapiens_hsa03030	0.91480310
43	Phototransduction_Homo sapiens_hsa04744	0.90702641
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90510085
45	Spliceosome_Homo sapiens_hsa03040	0.89716137
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85800543
47	Folate biosynthesis_Homo sapiens_hsa00790	0.85757345
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85666238
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.85581377
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84184962
51	Purine metabolism_Homo sapiens_hsa00230	0.82837831
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.81376016
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.79846032
54	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.79523409
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.77261455
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74872776
57	Metabolic pathways_Homo sapiens_hsa01100	0.74155511
58	Graft-versus-host disease_Homo sapiens_hsa05332	0.72411771
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70095397
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67715991
61	Caffeine metabolism_Homo sapiens_hsa00232	0.64717090
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57200741
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56811915
64	Non-homologous end-joining_Homo sapiens_hsa03450	0.55590037
65	Pyruvate metabolism_Homo sapiens_hsa00620	0.54304238
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53858604
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51040445
68	Retinol metabolism_Homo sapiens_hsa00830	0.51025625
69	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49423868
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49135108
71	Basal cell carcinoma_Homo sapiens_hsa05217	0.48280095
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.45539868
73	Glutathione metabolism_Homo sapiens_hsa00480	0.44139261
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43850400
75	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.43745598
76	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.43190554
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.40949867
78	Fatty acid degradation_Homo sapiens_hsa00071	0.39782515
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.39347112
80	Nicotine addiction_Homo sapiens_hsa05033	0.38182862
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.37205991
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35973345
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.35197985
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34029374
85	Sulfur metabolism_Homo sapiens_hsa00920	0.33934444
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.30563450
87	Olfactory transduction_Homo sapiens_hsa04740	0.30280932
88	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.25052448
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.22743091
90	Mineral absorption_Homo sapiens_hsa04978	0.21888426
91	Regulation of autophagy_Homo sapiens_hsa04140	0.21478434
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.20445155
93	Serotonergic synapse_Homo sapiens_hsa04726	0.19541286
94	Steroid biosynthesis_Homo sapiens_hsa00100	0.18913995
95	Morphine addiction_Homo sapiens_hsa05032	0.18323167
96	Insulin secretion_Homo sapiens_hsa04911	0.18269636
97	Taste transduction_Homo sapiens_hsa04742	0.17025334
98	Antigen processing and presentation_Homo sapiens_hsa04612	0.15825416
99	Tyrosine metabolism_Homo sapiens_hsa00350	0.15010910
100	p53 signaling pathway_Homo sapiens_hsa04115	0.13672914

RPL12P17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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