RPL12P18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.80067537
2ribosomal small subunit biogenesis (GO:0042274)7.73537847
3translational termination (GO:0006415)7.62813930
4ribosomal small subunit assembly (GO:0000028)7.33930715
5maturation of SSU-rRNA (GO:0030490)6.64184211
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.40357900
7cotranslational protein targeting to membrane (GO:0006613)6.32678986
8translational elongation (GO:0006414)6.30693930
9establishment of protein localization to mitochondrial membrane (GO:0090151)6.29809723
10protein targeting to ER (GO:0045047)6.28876722
11protein neddylation (GO:0045116)6.23995877
12establishment of protein localization to endoplasmic reticulum (GO:0072599)6.02529554
13protein localization to endoplasmic reticulum (GO:0070972)5.95228083
14cellular protein complex disassembly (GO:0043624)5.71821292
15viral life cycle (GO:0019058)5.57841908
16ATP synthesis coupled proton transport (GO:0015986)5.55783070
17energy coupled proton transport, down electrochemical gradient (GO:0015985)5.55783070
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.51645206
19behavioral response to nicotine (GO:0035095)5.27478308
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.10947572
21translational initiation (GO:0006413)4.95788450
22protein complex disassembly (GO:0043241)4.84843962
23chaperone-mediated protein transport (GO:0072321)4.83321194
24macromolecular complex disassembly (GO:0032984)4.59531627
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.51252622
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.51252622
27NADH dehydrogenase complex assembly (GO:0010257)4.51252622
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.40166249
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.40166249
30nuclear-transcribed mRNA catabolic process (GO:0000956)4.21400358
31protein complex biogenesis (GO:0070271)4.16913121
32protein targeting to membrane (GO:0006612)4.14810699
33translation (GO:0006412)3.99074321
34mRNA catabolic process (GO:0006402)3.98765748
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.83555372
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.78736912
37mitochondrial respiratory chain complex assembly (GO:0033108)3.78095648
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.71419698
39cardiovascular system development (GO:0072358)3.70506699
40respiratory electron transport chain (GO:0022904)3.68904019
41positive regulation of prostaglandin secretion (GO:0032308)3.68672986
42electron transport chain (GO:0022900)3.67408961
43ribosomal large subunit biogenesis (GO:0042273)3.66275224
44RNA catabolic process (GO:0006401)3.62166776
45DNA deamination (GO:0045006)3.57818882
46cellular component biogenesis (GO:0044085)3.55773603
47ribonucleoprotein complex biogenesis (GO:0022613)3.48837634
48cellular response to interferon-beta (GO:0035458)3.44805582
49rRNA catabolic process (GO:0016075)3.28574693
50substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.26366731
51substrate-independent telencephalic tangential migration (GO:0021826)3.26366731
52nonmotile primary cilium assembly (GO:0035058)3.25130552
53positive regulation of fatty acid transport (GO:2000193)3.19470326
54positive regulation of icosanoid secretion (GO:0032305)3.16806590
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.16100040
56water-soluble vitamin biosynthetic process (GO:0042364)3.15470879
57centriole replication (GO:0007099)3.12714070
58regulation of cellular respiration (GO:0043457)3.10918888
59endoderm formation (GO:0001706)3.10880425
60ncRNA 3-end processing (GO:0043628)3.10606934
61intracellular protein transmembrane import (GO:0044743)3.03451611
62ATP biosynthetic process (GO:0006754)3.00979106
63purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.99821247
64myoblast migration (GO:0051451)2.98940706
65GTP biosynthetic process (GO:0006183)2.96154692
66response to redox state (GO:0051775)2.95020680
67hydrogen ion transmembrane transport (GO:1902600)2.94622151
68purine nucleoside triphosphate biosynthetic process (GO:0009145)2.91037968
69regulation of prostaglandin secretion (GO:0032306)2.88552310
70protein targeting (GO:0006605)2.86173286
71rRNA metabolic process (GO:0016072)2.85798543
72rRNA processing (GO:0006364)2.85663589
73lens fiber cell development (GO:0070307)2.82783519
74establishment of protein localization to membrane (GO:0090150)2.82513347
75spliceosomal complex assembly (GO:0000245)2.77327725
76cell proliferation in forebrain (GO:0021846)2.76803791
77establishment of protein localization to organelle (GO:0072594)2.75475737
78rRNA modification (GO:0000154)2.75116577
79protein K6-linked ubiquitination (GO:0085020)2.74827618
80auditory receptor cell differentiation (GO:0042491)2.72647217
81platelet dense granule organization (GO:0060155)2.71966464
82proton transport (GO:0015992)2.70705191
83protein-cofactor linkage (GO:0018065)2.70518195
84tRNA processing (GO:0008033)2.69905133
85positive regulation of T cell apoptotic process (GO:0070234)2.69805645
86intraciliary transport (GO:0042073)2.67057100
87hydrogen transport (GO:0006818)2.63681416
88negative regulation of appetite (GO:0032099)2.61779901
89negative regulation of response to food (GO:0032096)2.61779901
90ribonucleoside triphosphate biosynthetic process (GO:0009201)2.60864189
91regulation of cilium movement (GO:0003352)2.59721388
92olfactory bulb development (GO:0021772)2.56672473
93radial glial cell differentiation (GO:0060019)2.56083435
94respiratory chain complex IV assembly (GO:0008535)2.54007105
95UTP metabolic process (GO:0046051)2.51830551
96reciprocal meiotic recombination (GO:0007131)2.50104092
97reciprocal DNA recombination (GO:0035825)2.50104092
98pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.49185193
99DNA strand renaturation (GO:0000733)2.49068137
100RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.48740701

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.40188560
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.21183189
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.97141144
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.74208370
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.38510481
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.19814814
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.07060333
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80896221
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.68705453
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57533703
11VDR_22108803_ChIP-Seq_LS180_Human2.36013587
12ZNF274_21170338_ChIP-Seq_K562_Hela2.35779400
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.29433775
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17708905
15VDR_23849224_ChIP-Seq_CD4+_Human2.04669646
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00048205
17TTF2_22483619_ChIP-Seq_HELA_Human1.95336054
18FOXP3_21729870_ChIP-Seq_TREG_Human1.90123881
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87693340
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86909293
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82332201
22ELK1_19687146_ChIP-ChIP_HELA_Human1.82170889
23MYC_18940864_ChIP-ChIP_HL60_Human1.79529681
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69504528
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66578899
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63142569
27XRN2_22483619_ChIP-Seq_HELA_Human1.57010429
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.55088130
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.54677973
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54462415
31IRF1_19129219_ChIP-ChIP_H3396_Human1.50894710
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49685009
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.48608611
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48250285
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46867712
36EWS_26573619_Chip-Seq_HEK293_Human1.44670984
37GABP_19822575_ChIP-Seq_HepG2_Human1.42768626
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39773857
39SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36830065
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36350269
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35613707
42IGF1R_20145208_ChIP-Seq_DFB_Human1.34894888
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33969661
44FUS_26573619_Chip-Seq_HEK293_Human1.33311928
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32351892
46KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32215979
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30997523
48TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28178163
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27677497
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.25274085
51TP53_22573176_ChIP-Seq_HFKS_Human1.23175489
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.23120953
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20622256
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18533482
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15874559
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14969247
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13504078
58NANOG_20526341_ChIP-Seq_ESCs_Human1.12286855
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12202770
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12118189
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08232401
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.07629384
63REST_21632747_ChIP-Seq_MESCs_Mouse1.07596558
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06920468
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.04329113
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03289844
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.03252103
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03252103
69EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02962167
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02702219
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02233476
72TAF2_19829295_ChIP-Seq_ESCs_Human1.00737818
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00677438
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.00543902
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96045345
76ERA_21632823_ChIP-Seq_H3396_Human0.95941528
77MYC_19829295_ChIP-Seq_ESCs_Human0.95930777
78CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95318996
79FOXH1_21741376_ChIP-Seq_EPCs_Human0.93803955
80P300_19829295_ChIP-Seq_ESCs_Human0.92389825
81REST_18959480_ChIP-ChIP_MESCs_Mouse0.91138066
82SOX2_19829295_ChIP-Seq_ESCs_Human0.90860362
83NANOG_19829295_ChIP-Seq_ESCs_Human0.90860362
84P53_21459846_ChIP-Seq_SAOS-2_Human0.88537724
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87324550
86E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87323976
87YY1_22570637_ChIP-Seq_MALME-3M_Human0.87319513
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86357291
89EZH2_27294783_Chip-Seq_ESCs_Mouse0.86088186
90HOXB7_26014856_ChIP-Seq_BT474_Human0.85669340
91PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84886319
92AR_20517297_ChIP-Seq_VCAP_Human0.84859491
93NCOR_22424771_ChIP-Seq_293T_Human0.83149066
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83107880
95E2F1_18555785_ChIP-Seq_MESCs_Mouse0.81671409
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80762911
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80167233
98EZH2_27304074_Chip-Seq_ESCs_Mouse0.79566490
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.79386052
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79211027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.27582262
2MP0009379_abnormal_foot_pigmentation4.18452825
3MP0006292_abnormal_olfactory_placode3.62093006
4MP0002837_dystrophic_cardiac_calcinosis3.50492669
5MP0008877_abnormal_DNA_methylation3.22895149
6MP0003787_abnormal_imprinting3.11469895
7MP0001485_abnormal_pinna_reflex2.55421630
8MP0002653_abnormal_ependyma_morphology2.53427866
9MP0003122_maternal_imprinting2.45286209
10MP0003878_abnormal_ear_physiology2.45214371
11MP0005377_hearing/vestibular/ear_phenot2.45214371
12MP0004142_abnormal_muscle_tone2.38739998
13MP0008789_abnormal_olfactory_epithelium2.37032816
14MP0000372_irregular_coat_pigmentation2.36180811
15MP0003123_paternal_imprinting2.21291969
16MP0006072_abnormal_retinal_apoptosis2.03697799
17MP0005499_abnormal_olfactory_system1.97707096
18MP0005394_taste/olfaction_phenotype1.97707096
19MP0002163_abnormal_gland_morphology1.88068460
20MP0003121_genomic_imprinting1.85462299
21MP0006276_abnormal_autonomic_nervous1.76875372
22MP0002102_abnormal_ear_morphology1.71886418
23MP0002938_white_spotting1.71792202
24MP0003693_abnormal_embryo_hatching1.66447307
25MP0003183_abnormal_peptide_metabolism1.57413081
26MP0001440_abnormal_grooming_behavior1.53294125
27MP0001968_abnormal_touch/_nociception1.49995090
28MP0001986_abnormal_taste_sensitivity1.49676042
29MP0008775_abnormal_heart_ventricle1.42331509
30MP0000049_abnormal_middle_ear1.41330006
31MP0001293_anophthalmia1.40780434
32MP0002736_abnormal_nociception_after1.39268772
33MP0002272_abnormal_nervous_system1.39158252
34MP0001486_abnormal_startle_reflex1.30098778
35MP0004742_abnormal_vestibular_system1.29387297
36MP0004145_abnormal_muscle_electrophysio1.28894126
37MP0004885_abnormal_endolymph1.25735831
38MP0005670_abnormal_white_adipose1.21045078
39MP0002638_abnormal_pupillary_reflex1.20673734
40MP0003890_abnormal_embryonic-extraembry1.20324623
41MP0002138_abnormal_hepatobiliary_system1.16886570
42MP0001529_abnormal_vocalization1.15984216
43MP0009046_muscle_twitch1.14544451
44MP0008872_abnormal_physiological_respon1.13025202
45MP0002234_abnormal_pharynx_morphology1.12573971
46MP0005075_abnormal_melanosome_morpholog1.11481143
47MP0000778_abnormal_nervous_system1.10919348
48MP0005253_abnormal_eye_physiology1.10019289
49MP0001970_abnormal_pain_threshold1.08271970
50MP0005084_abnormal_gallbladder_morpholo1.07538996
51MP0002572_abnormal_emotion/affect_behav1.07522015
52MP0003186_abnormal_redox_activity1.06408459
53MP0005389_reproductive_system_phenotype1.06367481
54MP0005551_abnormal_eye_electrophysiolog1.06318150
55MP0001919_abnormal_reproductive_system1.05189866
56MP0003786_premature_aging1.03883617
57MP0003195_calcinosis1.02896664
58MP0004133_heterotaxia1.02348635
59MP0002557_abnormal_social/conspecific_i1.01280847
60MP0003567_abnormal_fetal_cardiomyocyte0.99662469
61MP0009745_abnormal_behavioral_response0.99156516
62MP0000631_abnormal_neuroendocrine_gland0.95961670
63MP0002095_abnormal_skin_pigmentation0.95607759
64MP0002160_abnormal_reproductive_system0.95485719
65MP0003136_yellow_coat_color0.92772594
66MP0005195_abnormal_posterior_eye0.91640890
67MP0002277_abnormal_respiratory_mucosa0.90901740
68MP0005645_abnormal_hypothalamus_physiol0.90879203
69MP0003119_abnormal_digestive_system0.90190757
70MP0002876_abnormal_thyroid_physiology0.89821223
71MP0005646_abnormal_pituitary_gland0.89814194
72MP0002735_abnormal_chemical_nociception0.88438069
73MP0002210_abnormal_sex_determination0.87858799
74MP0000230_abnormal_systemic_arterial0.86689482
75MP0005647_abnormal_sex_gland0.85201880
76MP0009053_abnormal_anal_canal0.84145023
77MP0002067_abnormal_sensory_capabilities0.82040092
78MP0001348_abnormal_lacrimal_gland0.78809295
79MP0001502_abnormal_circadian_rhythm0.78743591
80MP0002063_abnormal_learning/memory/cond0.77708288
81MP0003938_abnormal_ear_development0.77502291
82MP0001963_abnormal_hearing_physiology0.76058240
83MP0005379_endocrine/exocrine_gland_phen0.74379367
84MP0002733_abnormal_thermal_nociception0.73580060
85MP0004381_abnormal_hair_follicle0.72666172
86MP0006036_abnormal_mitochondrial_physio0.72375392
87MP0002184_abnormal_innervation0.71526650
88MP0000516_abnormal_urinary_system0.70743849
89MP0005367_renal/urinary_system_phenotyp0.70743849
90MP0003880_abnormal_central_pattern0.70743423
91MP0008058_abnormal_DNA_repair0.70318032
92MP0003635_abnormal_synaptic_transmissio0.69805795
93MP0001119_abnormal_female_reproductive0.69211565
94MP0002254_reproductive_system_inflammat0.68929586
95MP0001905_abnormal_dopamine_level0.68860633
96MP0001984_abnormal_olfaction0.67635273
97MP0000653_abnormal_sex_gland0.67067257
98MP0001145_abnormal_male_reproductive0.66946237
99MP0002928_abnormal_bile_duct0.65586548
100MP0002752_abnormal_somatic_nervous0.65052894

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.02178223
2Acute necrotizing encephalopathy (HP:0006965)4.50258769
3Mitochondrial inheritance (HP:0001427)4.03423877
4Acute encephalopathy (HP:0006846)3.93230165
5Abnormal mitochondria in muscle tissue (HP:0008316)3.88544074
6Pancreatic fibrosis (HP:0100732)3.86368833
7Progressive macrocephaly (HP:0004481)3.79073755
8Increased hepatocellular lipid droplets (HP:0006565)3.72204997
9Increased CSF lactate (HP:0002490)3.60027930
10Molar tooth sign on MRI (HP:0002419)3.59681233
11Abnormality of midbrain morphology (HP:0002418)3.59681233
12Abnormality of cells of the erythroid lineage (HP:0012130)3.51247344
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.47182497
14Lipid accumulation in hepatocytes (HP:0006561)3.44687646
15Macrocytic anemia (HP:0001972)3.39145503
16Hepatocellular necrosis (HP:0001404)3.13833670
17Pancreatic cysts (HP:0001737)3.09767455
18Type II lissencephaly (HP:0007260)2.94568833
193-Methylglutaconic aciduria (HP:0003535)2.92392896
20Cerebral edema (HP:0002181)2.91821094
21Increased intramyocellular lipid droplets (HP:0012240)2.87445568
22Renal Fanconi syndrome (HP:0001994)2.82486653
23Oligodactyly (hands) (HP:0001180)2.80763889
24Abnormal rod and cone electroretinograms (HP:0008323)2.76199060
25Abnormality of the labia minora (HP:0012880)2.70596465
26True hermaphroditism (HP:0010459)2.67637516
27Pallor (HP:0000980)2.67118379
28Hepatic necrosis (HP:0002605)2.65764573
29Cystic liver disease (HP:0006706)2.65185871
30Cerebellar dysplasia (HP:0007033)2.64980851
31Medial flaring of the eyebrow (HP:0010747)2.64707767
32Abnormal number of erythroid precursors (HP:0012131)2.63747140
33Aplasia/Hypoplasia of the spleen (HP:0010451)2.58941221
34Tubulointerstitial nephritis (HP:0001970)2.58240810
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.55803646
36Increased serum lactate (HP:0002151)2.51633503
37Hyperglycinemia (HP:0002154)2.47947102
38Asplenia (HP:0001746)2.43533711
39Septo-optic dysplasia (HP:0100842)2.43191693
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40759607
41Oligodactyly (HP:0012165)2.38331606
42Increased muscle lipid content (HP:0009058)2.37661141
43Exertional dyspnea (HP:0002875)2.35644128
44Hypoplasia of the ulna (HP:0003022)2.34981490
45Double outlet right ventricle (HP:0001719)2.32818822
46Congenital malformation of the right heart (HP:0011723)2.32818822
47Intestinal atresia (HP:0011100)2.31389797
48Adrenal hypoplasia (HP:0000835)2.29182378
49Bile duct proliferation (HP:0001408)2.28966031
50Abnormal biliary tract physiology (HP:0012439)2.28966031
51Anencephaly (HP:0002323)2.27553763
52Postaxial foot polydactyly (HP:0001830)2.26459980
53Respiratory difficulties (HP:0002880)2.26058515
54Optic disc pallor (HP:0000543)2.25160590
55Growth hormone deficiency (HP:0000824)2.21121912
56Nephronophthisis (HP:0000090)2.21103796
57Colon cancer (HP:0003003)2.19454078
58Hypoplasia of the radius (HP:0002984)2.18890685
59Forearm undergrowth (HP:0009821)2.17577860
60Elevated erythrocyte sedimentation rate (HP:0003565)2.16037547
61Lactic acidosis (HP:0003128)2.14974857
62Chromsome breakage (HP:0040012)2.14385111
63Gait imbalance (HP:0002141)2.11326476
64Aplasia/Hypoplasia of the ulna (HP:0006495)2.10039674
65Congenital primary aphakia (HP:0007707)2.09471692
66Horseshoe kidney (HP:0000085)2.09271857
67Congenital stationary night blindness (HP:0007642)2.08397477
68Absent thumb (HP:0009777)2.08006502
69Fibular hypoplasia (HP:0003038)2.07372913
70Exercise intolerance (HP:0003546)2.07208065
71Agitation (HP:0000713)2.01880611
72Stenosis of the external auditory canal (HP:0000402)2.00859792
73Lissencephaly (HP:0001339)2.00847262
74Pendular nystagmus (HP:0012043)2.00192434
75Thyroid-stimulating hormone excess (HP:0002925)1.99300294
76Median cleft lip (HP:0000161)1.97480314
77Abnormality of renal resorption (HP:0011038)1.95802056
78Nephrogenic diabetes insipidus (HP:0009806)1.93346988
79Anomalous pulmonary venous return (HP:0010772)1.91794535
80Supernumerary spleens (HP:0009799)1.91354819
81Lethargy (HP:0001254)1.90691830
82Abolished electroretinogram (ERG) (HP:0000550)1.89174668
83Preaxial hand polydactyly (HP:0001177)1.87569341
84Glycosuria (HP:0003076)1.86187194
85Abnormality of urine glucose concentration (HP:0011016)1.86187194
86Dynein arm defect of respiratory motile cilia (HP:0012255)1.84805373
87Absent/shortened dynein arms (HP:0200106)1.84805373
88Stomatitis (HP:0010280)1.84736710
89Abnormality of the renal cortex (HP:0011035)1.84171047
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.84116911
91Respiratory failure (HP:0002878)1.83040241
92Leukodystrophy (HP:0002415)1.82155011
93Ectopic kidney (HP:0000086)1.81977998
94Chronic hepatic failure (HP:0100626)1.79985531
95Dyschromatopsia (HP:0007641)1.79512045
96Aplasia/Hypoplasia of the fibula (HP:0006492)1.77563178
97Myokymia (HP:0002411)1.77193832
98Polydipsia (HP:0001959)1.76188859
99Abnormal drinking behavior (HP:0030082)1.76188859
100Sclerocornea (HP:0000647)1.76066338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.80149097
2WNK43.80069051
3VRK22.88776241
4NUAK12.85938564
5EPHA32.81326499
6CAMKK22.73466606
7CDC72.50546632
8CDK192.48339848
9DYRK22.41749566
10STK392.31305468
11TNIK2.07555762
12LRRK22.06603736
13PAK31.95419823
14TAF11.90718351
15ADRBK21.90055822
16WNK31.78651607
17OXSR11.77360813
18MAP4K11.77241333
19PINK11.68281526
20GRK11.65607481
21FRK1.54554157
22EIF2AK11.51964277
23PNCK1.43613879
24SCYL21.40942077
25MKNK21.38240260
26PDK21.33016171
27CAMKK11.31401755
28BMPR1B1.28567380
29PLK41.27402114
30NME21.21548075
31IRAK11.21286522
32SMG11.15419649
33NLK1.15234360
34VRK11.14292296
35TIE11.13197749
36TLK11.11111304
37ICK1.10616963
38GRK51.06014363
39TYRO31.03436173
40INSRR1.00957422
41DAPK30.96666073
42EPHB20.93257901
43WNK10.90249849
44CAMK1G0.87474890
45ZAK0.84546890
46PIK3CA0.83806016
47DMPK0.83400457
48IKBKB0.82981341
49CAMK10.81067131
50PLK20.79267576
51BRD40.78237764
52BCKDK0.77280044
53CSNK1G20.76298563
54PASK0.75660423
55MAP3K90.73592188
56NTRK20.72903314
57STK160.72619935
58PRKCQ0.71798667
59NEK10.71212200
60PLK30.68495669
61IRAK40.67912198
62ATR0.66374140
63ADRBK10.64848427
64STK110.61592699
65CSNK1G30.61310376
66RPS6KA50.59579744
67MAP3K110.59388430
68RPS6KA40.57953366
69PRKCG0.57904008
70STK40.57822111
71GRK60.57317211
72LIMK10.55590233
73BRAF0.54506843
74TRIM280.54052346
75ARAF0.52609479
76FGFR20.52462050
77AKT30.52388456
78SGK4940.50226485
79SGK2230.50226485
80PRKCE0.48464632
81MAPKAPK50.48438649
82CSNK1G10.48324931
83MINK10.47270584
84MAP4K20.46542553
85MKNK10.45892572
86NEK20.44409441
87NME10.44272420
88PLK10.43202899
89CSNK2A20.42768746
90TEC0.42140610
91RPS6KA60.41182112
92PRKACA0.40887357
93CDK70.39057027
94PRKCH0.34609121
95CSNK1A1L0.34541670
96AKT20.34270435
97ITK0.33869536
98SRPK10.33346173
99PRKCZ0.31504875
100OBSCN0.31478930

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.48180293
2Oxidative phosphorylation_Homo sapiens_hsa001904.31287439
3Parkinsons disease_Homo sapiens_hsa050123.60189683
4RNA polymerase_Homo sapiens_hsa030202.78806503
5Huntingtons disease_Homo sapiens_hsa050162.63107641
6Alzheimers disease_Homo sapiens_hsa050102.32921747
7RNA degradation_Homo sapiens_hsa030182.26149466
8Cardiac muscle contraction_Homo sapiens_hsa042602.17845162
9Proteasome_Homo sapiens_hsa030502.16668301
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.09066778
11Homologous recombination_Homo sapiens_hsa034402.04660035
12Protein export_Homo sapiens_hsa030602.00929480
13Linoleic acid metabolism_Homo sapiens_hsa005911.95555986
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91008126
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87181776
16Mismatch repair_Homo sapiens_hsa034301.81843634
17Fanconi anemia pathway_Homo sapiens_hsa034601.77240553
18One carbon pool by folate_Homo sapiens_hsa006701.56689478
19DNA replication_Homo sapiens_hsa030301.48149917
20Asthma_Homo sapiens_hsa053101.46429938
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39973200
22Pyrimidine metabolism_Homo sapiens_hsa002401.36116147
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.35575855
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.27285806
25Collecting duct acid secretion_Homo sapiens_hsa049661.26585717
26Nicotine addiction_Homo sapiens_hsa050331.22876583
27Propanoate metabolism_Homo sapiens_hsa006401.19985155
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19609165
29Ether lipid metabolism_Homo sapiens_hsa005651.17212249
30Fat digestion and absorption_Homo sapiens_hsa049751.12077264
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08300246
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05534259
33Basal transcription factors_Homo sapiens_hsa030221.01417178
34Sulfur relay system_Homo sapiens_hsa041221.01347085
35RNA transport_Homo sapiens_hsa030130.97791943
36Purine metabolism_Homo sapiens_hsa002300.97716871
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94835566
38Antigen processing and presentation_Homo sapiens_hsa046120.94751530
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94035818
40Peroxisome_Homo sapiens_hsa041460.92742395
41Primary immunodeficiency_Homo sapiens_hsa053400.91913406
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91899474
43Vitamin B6 metabolism_Homo sapiens_hsa007500.91338912
44Nucleotide excision repair_Homo sapiens_hsa034200.90347277
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89975893
46Arachidonic acid metabolism_Homo sapiens_hsa005900.87216751
47Tryptophan metabolism_Homo sapiens_hsa003800.86992086
48Autoimmune thyroid disease_Homo sapiens_hsa053200.86482391
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85481183
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83338910
51Butanoate metabolism_Homo sapiens_hsa006500.82468964
52beta-Alanine metabolism_Homo sapiens_hsa004100.80218144
53Olfactory transduction_Homo sapiens_hsa047400.80110782
54Allograft rejection_Homo sapiens_hsa053300.78661763
55Metabolic pathways_Homo sapiens_hsa011000.78609424
56Glycerolipid metabolism_Homo sapiens_hsa005610.78239835
57Spliceosome_Homo sapiens_hsa030400.76623216
58Base excision repair_Homo sapiens_hsa034100.76528760
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73939074
60Fatty acid elongation_Homo sapiens_hsa000620.72877250
61Arginine and proline metabolism_Homo sapiens_hsa003300.72783433
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72341653
63Sulfur metabolism_Homo sapiens_hsa009200.69710505
64Type I diabetes mellitus_Homo sapiens_hsa049400.68999704
65Morphine addiction_Homo sapiens_hsa050320.67384155
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66946740
67Phototransduction_Homo sapiens_hsa047440.66798529
68Graft-versus-host disease_Homo sapiens_hsa053320.65749335
69Selenocompound metabolism_Homo sapiens_hsa004500.64226086
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63616820
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62962894
72Non-homologous end-joining_Homo sapiens_hsa034500.60812339
73Nitrogen metabolism_Homo sapiens_hsa009100.60400952
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57947190
75Fatty acid degradation_Homo sapiens_hsa000710.57505405
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55422261
77Basal cell carcinoma_Homo sapiens_hsa052170.53025732
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51057853
79Pyruvate metabolism_Homo sapiens_hsa006200.50984496
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.50871967
81Glutathione metabolism_Homo sapiens_hsa004800.50169352
82Caffeine metabolism_Homo sapiens_hsa002320.47965282
83Rheumatoid arthritis_Homo sapiens_hsa053230.47154622
84Vitamin digestion and absorption_Homo sapiens_hsa049770.43672938
85Chemical carcinogenesis_Homo sapiens_hsa052040.43130534
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39393653
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38266060
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37193603
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36973197
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35677589
91Retinol metabolism_Homo sapiens_hsa008300.35599328
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32241927
93GABAergic synapse_Homo sapiens_hsa047270.29986480
94p53 signaling pathway_Homo sapiens_hsa041150.27996079
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.26553167
96Steroid biosynthesis_Homo sapiens_hsa001000.26469481
97Viral myocarditis_Homo sapiens_hsa054160.26064874
98Synaptic vesicle cycle_Homo sapiens_hsa047210.23789263
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20426984
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.20016080

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