ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.63459090
2	maturation of SSU-rRNA (GO:0030490)	7.18592852
3	viral transcription (GO:0019083)	7.11875141
4	translational termination (GO:0006415)	6.84142216
5	ribosomal small subunit biogenesis (GO:0042274)	6.80982833
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.79792965
7	translational elongation (GO:0006414)	5.77547761
8	cotranslational protein targeting to membrane (GO:0006613)	5.70957577
9	protein targeting to ER (GO:0045047)	5.68973027
10	ribosomal large subunit biogenesis (GO:0042273)	5.48945069
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.46562549
12	protein localization to endoplasmic reticulum (GO:0070972)	5.34506860
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.30097159
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.30097159
15	NADH dehydrogenase complex assembly (GO:0010257)	5.30097159
16	chaperone-mediated protein transport (GO:0072321)	5.19220817
17	viral life cycle (GO:0019058)	5.16411068
18	cellular protein complex disassembly (GO:0043624)	5.14751551
19	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.01488108
20	ribonucleoprotein complex biogenesis (GO:0022613)	4.87726122
21	cysteine metabolic process (GO:0006534)	4.84979065
22	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.76758846
23	translational initiation (GO:0006413)	4.75876223
24	protein complex biogenesis (GO:0070271)	4.75356532
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.68561126
26	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.66322046
27	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.66322046
28	cellular component biogenesis (GO:0044085)	4.64252910
29	ATP synthesis coupled proton transport (GO:0015986)	4.59189586
30	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.59189586
31	behavioral response to nicotine (GO:0035095)	4.50883677
32	protein complex disassembly (GO:0043241)	4.34763802
33	mitochondrial respiratory chain complex assembly (GO:0033108)	4.32710694
34	GTP biosynthetic process (GO:0006183)	4.27502475
35	translation (GO:0006412)	4.14646111
36	macromolecular complex disassembly (GO:0032984)	4.08795894
37	protein-cofactor linkage (GO:0018065)	4.06614897
38	ribosome biogenesis (GO:0042254)	4.05351777
39	rRNA modification (GO:0000154)	4.05173277
40	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.98485221
41	UTP biosynthetic process (GO:0006228)	3.88896033
42	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.88687494
43	regulation of mitochondrial translation (GO:0070129)	3.87252904
44	protein targeting to membrane (GO:0006612)	3.83257506
45	chromatin remodeling at centromere (GO:0031055)	3.81638554
46	UTP metabolic process (GO:0046051)	3.75426132
47	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.74301713
48	response to xenobiotic stimulus (GO:0009410)	3.72809925
49	rRNA processing (GO:0006364)	3.69882339
50	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.67343988
51	folic acid-containing compound biosynthetic process (GO:0009396)	3.63788280
52	respiratory electron transport chain (GO:0022904)	3.61434398
53	homocysteine metabolic process (GO:0050667)	3.61171049
54	L-serine metabolic process (GO:0006563)	3.60121536
55	electron transport chain (GO:0022900)	3.59267478
56	termination of RNA polymerase III transcription (GO:0006386)	3.58808719
57	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.58808719
58	rRNA metabolic process (GO:0016072)	3.58792477
59	CENP-A containing nucleosome assembly (GO:0034080)	3.54823916
60	mRNA catabolic process (GO:0006402)	3.53531070
61	rRNA methylation (GO:0031167)	3.39893063
62	DNA deamination (GO:0045006)	3.31254800
63	RNA catabolic process (GO:0006401)	3.24962589
64	pseudouridine synthesis (GO:0001522)	3.22911216
65	kinetochore assembly (GO:0051382)	3.21636472
66	response to nitrosative stress (GO:0051409)	3.19764914
67	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.16724803
68	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.14808052
69	guanosine-containing compound biosynthetic process (GO:1901070)	3.11880282
70	positive regulation of T cell apoptotic process (GO:0070234)	3.11712965
71	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.11484326
72	CTP metabolic process (GO:0046036)	3.04391057
73	CTP biosynthetic process (GO:0006241)	3.04391057
74	intracellular protein transmembrane import (GO:0044743)	2.99731611
75	tRNA processing (GO:0008033)	2.99717166
76	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.96040184
77	serine family amino acid biosynthetic process (GO:0009070)	2.95821212
78	respiratory chain complex IV assembly (GO:0008535)	2.95694719
79	negative regulation of T cell differentiation in thymus (GO:0033085)	2.94700325
80	histone exchange (GO:0043486)	2.92052478
81	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.91919165
82	kinetochore organization (GO:0051383)	2.88685959
83	ncRNA processing (GO:0034470)	2.88283938
84	cytochrome complex assembly (GO:0017004)	2.85078883
85	sulfur amino acid catabolic process (GO:0000098)	2.83537807
86	proteasome assembly (GO:0043248)	2.83420574
87	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.83348150
88	DNA replication checkpoint (GO:0000076)	2.82296324
89	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.79802641
90	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.78978111
91	replication fork processing (GO:0031297)	2.78724004
92	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.77579523
93	purine nucleotide salvage (GO:0032261)	2.74874615
94	ATP biosynthetic process (GO:0006754)	2.74847016
95	protein neddylation (GO:0045116)	2.72429588
96	DNA replication-independent nucleosome assembly (GO:0006336)	2.71794525
97	DNA replication-independent nucleosome organization (GO:0034724)	2.71794525
98	inner mitochondrial membrane organization (GO:0007007)	2.71394075
99	mitochondrial RNA metabolic process (GO:0000959)	2.69940784
100	adenosine metabolic process (GO:0046085)	2.67707168

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.42224227
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.37840967
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.18679003
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.09123703
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.07736960
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.74862780
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.49472189
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.38441789
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.33700139
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.29555447
11	EZH2_22144423_ChIP-Seq_EOC_Human	3.17364370
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.12902712
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.47294424
14	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.41649241
15	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.40466826
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.25575729
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.23512306
18	TTF2_22483619_ChIP-Seq_HELA_Human	2.20838601
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.20018323
20	XRN2_22483619_ChIP-Seq_HELA_Human	2.17450237
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.97394334
22	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.93525856
23	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.89374066
24	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.87751877
25	GABP_19822575_ChIP-Seq_HepG2_Human	1.86819278
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.79522535
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.72540300
28	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.70425513
29	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.69909839
30	ZNF274_21170338_ChIP-Seq_K562_Hela	1.68182005
31	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.63537980
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.59931688
33	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.57933949
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.56082758
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.55381406
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.54316168
37	VDR_22108803_ChIP-Seq_LS180_Human	1.52752814
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52697587
39	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.46426734
40	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.45941565
41	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.44898458
42	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.42439829
43	E2F7_22180533_ChIP-Seq_HELA_Human	1.41000118
44	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.38113630
45	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.33158799
46	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.31847144
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30715905
48	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.26249262
49	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.20245374
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.19366309
51	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18340366
52	STAT1_20625510_ChIP-Seq_HELA_Human	1.17970749
53	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.16907530
54	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.14127040
55	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.12910729
56	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.11726556
57	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.11403507
58	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.10690147
59	ERA_21632823_ChIP-Seq_H3396_Human	1.08494789
60	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.08204833
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05862436
62	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.02645656
63	NCOR_22424771_ChIP-Seq_293T_Human	1.01665869
64	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.01610755
65	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.01497840
66	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.00820028
67	DCP1A_22483619_ChIP-Seq_HELA_Human	1.00657992
68	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.00580439
69	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.00505000
70	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.99869166
71	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97459106
72	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.97071744
73	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.96008501
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94221519
75	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.93901135
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93455986
77	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.92683722
78	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92091323
79	EWS_26573619_Chip-Seq_HEK293_Human	0.91243243
80	KDM5A_27292631_Chip-Seq_BREAST_Human	0.90944859
81	P53_21459846_ChIP-Seq_SAOS-2_Human	0.88300763
82	HOXB7_26014856_ChIP-Seq_BT474_Human	0.87138604
83	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.86747769
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.86436487
85	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.86136799
86	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.85279721
87	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.84460577
88	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.83621352
89	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.83621352
90	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.83443158
91	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.83080084
92	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.82846923
93	CTCF_20526341_ChIP-Seq_ESCs_Human	0.82831220
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.82758668
95	FUS_26573619_Chip-Seq_HEK293_Human	0.82093029
96	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.81791179
97	MYC_19829295_ChIP-Seq_ESCs_Human	0.81375064
98	E2F1_20622854_ChIP-Seq_HELA_Human	0.80921886
99	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.80381691
100	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.79318972

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.86899515
2	MP0006292_abnormal_olfactory_placode	4.87015611
3	MP0005377_hearing/vestibular/ear_phenot	3.32481008
4	MP0003878_abnormal_ear_physiology	3.32481008
5	MP0004147_increased_porphyrin_level	2.91901116
6	MP0002736_abnormal_nociception_after	2.83351649
7	MP0003806_abnormal_nucleotide_metabolis	2.60103192
8	MP0005360_urolithiasis	2.45694699
9	MP0002138_abnormal_hepatobiliary_system	2.42051827
10	MP0002938_white_spotting	2.36056783
11	MP0001293_anophthalmia	2.35774878
12	MP0001968_abnormal_touch/_nociception	2.19434612
13	MP0004885_abnormal_endolymph	2.14488121
14	MP0000049_abnormal_middle_ear	2.02651144
15	MP0005646_abnormal_pituitary_gland	2.02273108
16	MP0008872_abnormal_physiological_respon	1.93572741
17	MP0002132_abnormal_respiratory_system	1.87487459
18	MP0003787_abnormal_imprinting	1.81509622
19	MP0002837_dystrophic_cardiac_calcinosis	1.78247448
20	MP0010030_abnormal_orbit_morphology	1.74515046
21	MP0003693_abnormal_embryo_hatching	1.73572050
22	MP0008877_abnormal_DNA_methylation	1.71757699
23	MP0003186_abnormal_redox_activity	1.68212753
24	MP0001764_abnormal_homeostasis	1.65453386
25	MP0008058_abnormal_DNA_repair	1.62809024
26	MP0000631_abnormal_neuroendocrine_gland	1.60321853
27	MP0008789_abnormal_olfactory_epithelium	1.55259128
28	MP0002160_abnormal_reproductive_system	1.52114763
29	MP0005670_abnormal_white_adipose	1.51141790
30	MP0002234_abnormal_pharynx_morphology	1.49403338
31	MP0003646_muscle_fatigue	1.44788822
32	MP0009053_abnormal_anal_canal	1.38524817
33	MP0001485_abnormal_pinna_reflex	1.36405827
34	MP0002095_abnormal_skin_pigmentation	1.35759946
35	MP0004142_abnormal_muscle_tone	1.30769420
36	MP0002102_abnormal_ear_morphology	1.29534117
37	MP0003011_delayed_dark_adaptation	1.25441937
38	MP0001661_extended_life_span	1.24767856
39	MP0005389_reproductive_system_phenotype	1.21842456
40	MP0005423_abnormal_somatic_nervous	1.21276520
41	MP0003937_abnormal_limbs/digits/tail_de	1.21220820
42	MP0006072_abnormal_retinal_apoptosis	1.20176067
43	MP0005551_abnormal_eye_electrophysiolog	1.19100384
44	MP0008995_early_reproductive_senescence	1.17435350
45	MP0004043_abnormal_pH_regulation	1.14797421
46	MP0003938_abnormal_ear_development	1.14617034
47	MP0003136_yellow_coat_color	1.13319372
48	MP0003121_genomic_imprinting	1.09525399
49	MP0005499_abnormal_olfactory_system	1.09109676
50	MP0005394_taste/olfaction_phenotype	1.09109676
51	MP0005645_abnormal_hypothalamus_physiol	1.07290851
52	MP0002210_abnormal_sex_determination	1.06442849
53	MP0005332_abnormal_amino_acid	1.06258189
54	MP0003890_abnormal_embryonic-extraembry	1.05457458
55	MP0000026_abnormal_inner_ear	1.05412659
56	MP0000566_synostosis	1.04638268
57	MP0003567_abnormal_fetal_cardiomyocyte	1.03889507
58	MP0003122_maternal_imprinting	1.03532951
59	MP0002876_abnormal_thyroid_physiology	1.03029259
60	MP0000750_abnormal_muscle_regeneration	1.02180644
61	MP0003111_abnormal_nucleus_morphology	0.99747953
62	MP0002277_abnormal_respiratory_mucosa	0.98933748
63	MP0003195_calcinosis	0.98742153
64	MP0002735_abnormal_chemical_nociception	0.97256550
65	MP0003786_premature_aging	0.95765197
66	MP0005410_abnormal_fertilization	0.94384981
67	MP0001286_abnormal_eye_development	0.94329124
68	MP0004957_abnormal_blastocyst_morpholog	0.91817069
69	MP0004742_abnormal_vestibular_system	0.91608998
70	MP0008875_abnormal_xenobiotic_pharmacok	0.89763111
71	MP0003183_abnormal_peptide_metabolism	0.88758215
72	MP0000653_abnormal_sex_gland	0.85603648
73	MP0003123_paternal_imprinting	0.84401564
74	MP0005253_abnormal_eye_physiology	0.82919095
75	MP0006276_abnormal_autonomic_nervous	0.82673011
76	MP0005636_abnormal_mineral_homeostasis	0.81914509
77	MP0002249_abnormal_larynx_morphology	0.81769657
78	MP0001145_abnormal_male_reproductive	0.81478999
79	MP0003942_abnormal_urinary_system	0.81199657
80	MP0001986_abnormal_taste_sensitivity	0.79207644
81	MP0010094_abnormal_chromosome_stability	0.79024846
82	MP0005174_abnormal_tail_pigmentation	0.78081939
83	MP0000685_abnormal_immune_system	0.77432638
84	MP0005391_vision/eye_phenotype	0.75626945
85	MP0003718_maternal_effect	0.73982545
86	MP0001929_abnormal_gametogenesis	0.73286767
87	MP0001502_abnormal_circadian_rhythm	0.73125340
88	MP0000647_abnormal_sebaceous_gland	0.72930552
89	MP0001919_abnormal_reproductive_system	0.72426979
90	MP0009250_abnormal_appendicular_skeleto	0.72338798
91	MP0003698_abnormal_male_reproductive	0.72294723
92	MP0008775_abnormal_heart_ventricle	0.70766215
93	MP0000372_irregular_coat_pigmentation	0.70104458
94	MP0001905_abnormal_dopamine_level	0.69620277
95	MP0002272_abnormal_nervous_system	0.69299729
96	MP0004019_abnormal_vitamin_homeostasis	0.68972469
97	MP0003936_abnormal_reproductive_system	0.68695058
98	MP0005084_abnormal_gallbladder_morpholo	0.67877914
99	MP0002697_abnormal_eye_size	0.67496426
100	MP0001348_abnormal_lacrimal_gland	0.67274822

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.13049466
2	Acute necrotizing encephalopathy (HP:0006965)	4.94275697
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.70383296
4	Acute encephalopathy (HP:0006846)	4.43194816
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.27912102
6	Abnormal number of erythroid precursors (HP:0012131)	4.17375577
7	Macrocytic anemia (HP:0001972)	4.14140950
8	Progressive macrocephaly (HP:0004481)	3.92382253
9	Septo-optic dysplasia (HP:0100842)	3.90282561
10	Mitochondrial inheritance (HP:0001427)	3.82908347
11	Short middle phalanx of the 5th finger (HP:0004220)	3.45519879
12	Increased CSF lactate (HP:0002490)	3.45247011
13	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.40520988
14	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.28622617
15	Abnormality of alanine metabolism (HP:0010916)	3.28622617
16	Hyperalaninemia (HP:0003348)	3.28622617
17	Cerebral edema (HP:0002181)	3.17781387
18	Hepatocellular necrosis (HP:0001404)	3.13057543
19	Pallor (HP:0000980)	3.08781096
20	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.90640370
21	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.87599326
22	Maternal diabetes (HP:0009800)	2.78257661
23	Constricted visual fields (HP:0001133)	2.78255150
24	Rib fusion (HP:0000902)	2.77749366
25	Hepatic necrosis (HP:0002605)	2.76543224
26	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.71723762
27	Abnormality of DNA repair (HP:0003254)	2.70222577
28	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.66410108
29	Birth length less than 3rd percentile (HP:0003561)	2.61134760
30	Abnormality of midbrain morphology (HP:0002418)	2.59501341
31	Molar tooth sign on MRI (HP:0002419)	2.59501341
32	Abnormality of the labia minora (HP:0012880)	2.56359938
33	Colon cancer (HP:0003003)	2.55013633
34	Pendular nystagmus (HP:0012043)	2.50066704
35	Absent septum pellucidum (HP:0001331)	2.41287617
36	Congenital, generalized hypertrichosis (HP:0004540)	2.37627943
37	Lactic acidosis (HP:0003128)	2.35661259
38	Chronic hepatic failure (HP:0100626)	2.32745949
39	Lethargy (HP:0001254)	2.24662409
40	Increased serum lactate (HP:0002151)	2.23929887
41	Optic disc pallor (HP:0000543)	2.22727204
42	Pancreatic fibrosis (HP:0100732)	2.19054098
43	Absent thumb (HP:0009777)	2.16182952
44	Pancreatic cysts (HP:0001737)	2.15101522
45	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.14744993
46	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.13462990
47	Ectopic kidney (HP:0000086)	2.13152296
48	Optic nerve hypoplasia (HP:0000609)	2.10765897
49	Type II lissencephaly (HP:0007260)	2.09456892
50	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.07857116
51	Esophageal atresia (HP:0002032)	2.05909039
52	Bile duct proliferation (HP:0001408)	2.04414181
53	Abnormal biliary tract physiology (HP:0012439)	2.04414181
54	Hyperglycinemia (HP:0002154)	2.04343495
55	Leukodystrophy (HP:0002415)	2.02592390
56	Abnormality of the middle phalanges of the toes (HP:0010183)	2.01847790
57	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.00604633
58	Increased hepatocellular lipid droplets (HP:0006565)	1.99160510
59	Anophthalmia (HP:0000528)	1.98659111
60	Abnormality of the renal collecting system (HP:0004742)	1.98634954
61	Respiratory failure (HP:0002878)	1.97796628
62	Abnormal rod and cone electroretinograms (HP:0008323)	1.97337174
63	Anencephaly (HP:0002323)	1.95873157
64	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.94112968
65	Hyperthyroidism (HP:0000836)	1.92055561
66	Abnormality of the 4th metacarpal (HP:0010012)	1.91669251
67	Occipital encephalocele (HP:0002085)	1.91187860
68	Depressed nasal ridge (HP:0000457)	1.90525121
69	Abnormality of the septum pellucidum (HP:0007375)	1.90204915
70	3-Methylglutaconic aciduria (HP:0003535)	1.89990613
71	Abnormality of cochlea (HP:0000375)	1.89372920
72	Asplenia (HP:0001746)	1.88933053
73	Supernumerary spleens (HP:0009799)	1.88742666
74	Hypoplasia of the radius (HP:0002984)	1.86650438
75	Entropion (HP:0000621)	1.86072539
76	Abnormality of serum amino acid levels (HP:0003112)	1.85519306
77	Lipid accumulation in hepatocytes (HP:0006561)	1.81473671
78	Horseshoe kidney (HP:0000085)	1.81336757
79	True hermaphroditism (HP:0010459)	1.79779302
80	Pancytopenia (HP:0001876)	1.79688786
81	Elevated erythrocyte sedimentation rate (HP:0003565)	1.79330058
82	Chromsome breakage (HP:0040012)	1.77513645
83	Duplicated collecting system (HP:0000081)	1.75548121
84	Abolished electroretinogram (ERG) (HP:0000550)	1.74112769
85	Abnormal number of incisors (HP:0011064)	1.73616809
86	Small hand (HP:0200055)	1.73383676
87	Oligodactyly (HP:0012165)	1.73132236
88	Sclerocornea (HP:0000647)	1.71729488
89	Exercise intolerance (HP:0003546)	1.70975805
90	Neutropenia (HP:0001875)	1.70717472
91	Stenosis of the external auditory canal (HP:0000402)	1.69511171
92	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.68284387
93	Short 5th finger (HP:0009237)	1.68144779
94	Triphalangeal thumb (HP:0001199)	1.67967237
95	Delayed CNS myelination (HP:0002188)	1.67022555
96	11 pairs of ribs (HP:0000878)	1.66811381
97	Poor speech (HP:0002465)	1.66722140
98	Oligodactyly (hands) (HP:0001180)	1.65981417
99	Metabolic acidosis (HP:0001942)	1.65957438
100	Squamous cell carcinoma (HP:0002860)	1.62642966

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.34793655
2	STK16	4.04571646
3	NME1	3.04308744
4	NUAK1	3.03828275
5	CDC7	3.03047010
6	DYRK2	2.95421303
7	CDK19	2.95336272
8	EPHB2	2.58371216
9	MAP4K2	2.29849227
10	PDK2	2.26480816
11	TAF1	2.24276115
12	WNK4	2.20196519
13	TXK	2.01469447
14	ADRBK2	1.96648208
15	ZAK	1.91849688
16	PLK4	1.91219731
17	PIK3CA	1.60562218
18	VRK1	1.57491815
19	CDK8	1.44107263
20	TLK1	1.43417538
21	RPS6KB2	1.40755891
22	GRK1	1.40339379
23	BMPR1B	1.34952972
24	BCKDK	1.31597221
25	WNK3	1.29796344
26	ACVR1B	1.25183368
27	PASK	1.24276715
28	BUB1	1.21544191
29	TIE1	1.19194762
30	SRPK1	1.17540100
31	CAMK1	1.11011565
32	OXSR1	1.09650851
33	NME2	1.05834055
34	ATR	1.01044560
35	TEC	0.94137202
36	PRKD3	0.93485821
37	STK39	0.93285309
38	FRK	0.90491575
39	MAP3K11	0.89317225
40	WNK1	0.88768294
41	CAMK1D	0.88261271
42	CAMKK2	0.88216389
43	PLK1	0.84721424
44	NEK1	0.84695311
45	MAP3K4	0.84688094
46	AURKB	0.83235655
47	PLK3	0.81857484
48	CAMK1G	0.80560227
49	AURKA	0.79647471
50	CHEK2	0.79041792
51	PRKCI	0.78212592
52	CDK9	0.78100938
53	INSRR	0.77569628
54	CSNK2A2	0.75703468
55	PRKCG	0.75242876
56	EIF2AK1	0.73474056
57	ADRBK1	0.73347391
58	PINK1	0.72003280
59	DAPK3	0.70826654
60	NTRK2	0.69928143
61	SMG1	0.67831985
62	TGFBR1	0.66464472
63	MAPKAPK5	0.65792784
64	PAK3	0.64785312
65	NEK2	0.63781509
66	HIPK2	0.61290656
67	IKBKB	0.61274352
68	MKNK2	0.59892440
69	CSNK1G2	0.59410241
70	TRIM28	0.58910947
71	TAOK3	0.58755017
72	CDK7	0.58525591
73	CSNK1A1	0.57469633
74	LRRK2	0.56614580
75	IRAK4	0.54231989
76	MAP2K7	0.52585386
77	CSNK2A1	0.52468875
78	PNCK	0.50008827
79	GRK5	0.49213117
80	RPS6KA6	0.48124643
81	CSNK1G3	0.47737565
82	ITK	0.46735991
83	CAMKK1	0.44219312
84	PRKCQ	0.43675221
85	RPS6KA1	0.43123473
86	TYRO3	0.42048481
87	EIF2AK2	0.40829574
88	RPS6KA5	0.39823160
89	CSNK1E	0.39593974
90	MAP4K1	0.39593370
91	CDK3	0.38835959
92	DMPK	0.38206746
93	IRAK2	0.37498229
94	EPHA4	0.35812483
95	CHEK1	0.34787926
96	SGK494	0.34079131
97	SGK223	0.34079131
98	ABL2	0.32942346
99	CSNK1A1L	0.31992652
100	CSNK1G1	0.31811609

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.11109589
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.56528680
3	Parkinsons disease_Homo sapiens_hsa05012	2.88690419
4	RNA polymerase_Homo sapiens_hsa03020	2.86181270
5	One carbon pool by folate_Homo sapiens_hsa00670	2.46595002
6	Proteasome_Homo sapiens_hsa03050	2.36560175
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.29275425
8	Huntingtons disease_Homo sapiens_hsa05016	2.23927845
9	Homologous recombination_Homo sapiens_hsa03440	2.22228580
10	DNA replication_Homo sapiens_hsa03030	2.21876321
11	Mismatch repair_Homo sapiens_hsa03430	2.12557053
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.06368088
13	Sulfur relay system_Homo sapiens_hsa04122	1.99140098
14	Alzheimers disease_Homo sapiens_hsa05010	1.97444739
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.95106224
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.91450097
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.85859561
18	RNA degradation_Homo sapiens_hsa03018	1.83861332
19	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.79667780
20	Protein export_Homo sapiens_hsa03060	1.78042352
21	Base excision repair_Homo sapiens_hsa03410	1.75747551
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.69309023
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.62915971
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.61326569
25	Spliceosome_Homo sapiens_hsa03040	1.57822413
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.34083240
27	Basal transcription factors_Homo sapiens_hsa03022	1.31920824
28	RNA transport_Homo sapiens_hsa03013	1.25032785
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.24883165
30	Peroxisome_Homo sapiens_hsa04146	1.22030226
31	Purine metabolism_Homo sapiens_hsa00230	1.19549078
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.18219910
33	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.16318241
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.16165226
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.14892324
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.14068297
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.12319644
38	Asthma_Homo sapiens_hsa05310	1.10050595
39	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.09939100
40	Propanoate metabolism_Homo sapiens_hsa00640	1.08586246
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05981261
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.05341744
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.00985301
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00526690
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.98305693
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90977315
47	Butanoate metabolism_Homo sapiens_hsa00650	0.88357474
48	Regulation of autophagy_Homo sapiens_hsa04140	0.86847408
49	Glutathione metabolism_Homo sapiens_hsa00480	0.85407164
50	Retinol metabolism_Homo sapiens_hsa00830	0.84753079
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83427495
52	Metabolic pathways_Homo sapiens_hsa01100	0.81536155
53	Primary immunodeficiency_Homo sapiens_hsa05340	0.81121120
54	Fatty acid degradation_Homo sapiens_hsa00071	0.79809590
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.78377597
56	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.76752385
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76108232
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.75553532
59	Arginine and proline metabolism_Homo sapiens_hsa00330	0.72444766
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.72159158
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72002096
62	Folate biosynthesis_Homo sapiens_hsa00790	0.68220818
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68154011
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.68027747
65	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.66871475
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66104446
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.65207656
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.63347716
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61794244
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60330283
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59301209
72	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58586701
73	Nicotine addiction_Homo sapiens_hsa05033	0.57677456
74	Allograft rejection_Homo sapiens_hsa05330	0.55887543
75	Arginine biosynthesis_Homo sapiens_hsa00220	0.53855331
76	Ether lipid metabolism_Homo sapiens_hsa00565	0.53668862
77	Sulfur metabolism_Homo sapiens_hsa00920	0.51539926
78	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.50591024
79	Type I diabetes mellitus_Homo sapiens_hsa04940	0.49588280
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49153622
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48136301
82	Basal cell carcinoma_Homo sapiens_hsa05217	0.44952673
83	Morphine addiction_Homo sapiens_hsa05032	0.43245219
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42528314
85	Galactose metabolism_Homo sapiens_hsa00052	0.40430605
86	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.39338944
87	Olfactory transduction_Homo sapiens_hsa04740	0.38629725
88	Serotonergic synapse_Homo sapiens_hsa04726	0.37607768
89	Phototransduction_Homo sapiens_hsa04744	0.36668296
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36463496
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36446576
92	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.33056002
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.31171605
94	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.31038090
95	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.28634156
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.28327000
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27659462
98	Caffeine metabolism_Homo sapiens_hsa00232	0.27513582
99	Graft-versus-host disease_Homo sapiens_hsa05332	0.25801964
100	p53 signaling pathway_Homo sapiens_hsa04115	0.25116208

RPL12P19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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