RPL12P20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)5.88991184
2ubiquinone metabolic process (GO:0006743)5.81289082
3positive regulation of sodium ion transmembrane transporter activity (GO:2000651)5.70507056
4regulation of cytokine production involved in inflammatory response (GO:1900015)5.68846676
5neuronal action potential propagation (GO:0019227)5.34147564
6protein maturation by protein folding (GO:0022417)5.25117488
7ubiquinone biosynthetic process (GO:0006744)5.11481316
8response to redox state (GO:0051775)5.06847970
9estrogen biosynthetic process (GO:0006703)5.01313263
10dopamine transport (GO:0015872)4.82587333
11positive regulation of sodium ion transmembrane transport (GO:1902307)4.65057194
12behavioral response to nicotine (GO:0035095)4.48364438
13astrocyte differentiation (GO:0048708)4.42192517
14cellular response to electrical stimulus (GO:0071257)4.41146976
15negative regulation of heart rate (GO:0010459)4.35497429
16behavioral response to ethanol (GO:0048149)4.34362565
17positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.25211298
18negative regulation of calcium ion transport into cytosol (GO:0010523)4.23891377
19quinone biosynthetic process (GO:1901663)4.15448584
20DNA damage induced protein phosphorylation (GO:0006975)4.14761596
21regulation of glucocorticoid secretion (GO:2000849)4.05675591
22negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.95884073
23protein-chromophore linkage (GO:0018298)3.87415752
24photoreceptor cell differentiation (GO:0046530)3.85546853
25eye photoreceptor cell differentiation (GO:0001754)3.85546853
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.83128458
27nonmotile primary cilium assembly (GO:0035058)3.81835760
28dermatan sulfate biosynthetic process (GO:0030208)3.80506563
29early endosome to late endosome transport (GO:0045022)3.76716413
30membrane depolarization during action potential (GO:0086010)3.76638913
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.71640986
32dorsal/ventral axis specification (GO:0009950)3.71598454
33positive regulation of dendritic spine development (GO:0060999)3.70303307
34regulation of short-term neuronal synaptic plasticity (GO:0048172)3.69404534
35inactivation of MAPK activity (GO:0000188)3.64638739
36postsynaptic membrane organization (GO:0001941)3.62806200
37negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.55002692
38photoperiodism (GO:0009648)3.53839205
39negative regulation of circadian rhythm (GO:0042754)3.53636603
40sarcoplasmic reticulum calcium ion transport (GO:0070296)3.48167723
41regulation of neuron projection regeneration (GO:0070570)3.47922853
42regulation of axon regeneration (GO:0048679)3.47922853
43insulin secretion (GO:0030073)3.46420860
44aldehyde catabolic process (GO:0046185)3.45414371
45negative regulation of cation channel activity (GO:2001258)3.44577267
46pattern specification involved in kidney development (GO:0061004)3.43873003
47positive regulation of vesicle fusion (GO:0031340)3.43175792
48protein export from nucleus (GO:0006611)3.41889799
49toxin metabolic process (GO:0009404)3.41471588
50dermatan sulfate metabolic process (GO:0030205)3.40671196
51regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.40603966
52negative regulation of calcium ion transmembrane transport (GO:1903170)3.32079767
53negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.32079767
54regulation of actin nucleation (GO:0051125)3.30702779
55ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.24548088
56positive regulation of action potential (GO:0045760)3.21756056
57regulation of corticosteroid hormone secretion (GO:2000846)3.18862837
58negative regulation of sequestering of calcium ion (GO:0051283)3.16912342
59release of sequestered calcium ion into cytosol (GO:0051209)3.16912342
60substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.15841390
61substrate-independent telencephalic tangential migration (GO:0021826)3.15841390
62fucose catabolic process (GO:0019317)3.14098639
63L-fucose metabolic process (GO:0042354)3.14098639
64L-fucose catabolic process (GO:0042355)3.14098639
65serotonin metabolic process (GO:0042428)3.12833498
66piRNA metabolic process (GO:0034587)3.12147800
67negative regulation of neurotransmitter transport (GO:0051589)3.08449551
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.07486898
69collecting duct development (GO:0072044)3.06377090
70catecholamine transport (GO:0051937)3.05318401
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.03322008
72synaptic vesicle maturation (GO:0016188)2.99073359
73regulation of sequestering of calcium ion (GO:0051282)2.98630157
74regulation of calcium ion-dependent exocytosis (GO:0017158)2.98235582
75smooth muscle contraction (GO:0006939)2.96879381
76glycerophospholipid catabolic process (GO:0046475)2.93313609
77ionotropic glutamate receptor signaling pathway (GO:0035235)2.91373807
78response to vitamin E (GO:0033197)2.88304080
79entrainment of circadian clock by photoperiod (GO:0043153)2.88195371
80regulation of glycogen (starch) synthase activity (GO:2000465)2.85783506
81primary amino compound metabolic process (GO:1901160)2.82085197
82negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81026466
83negative regulation of translation, ncRNA-mediated (GO:0040033)2.81026466
84regulation of translation, ncRNA-mediated (GO:0045974)2.81026466
85regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.80276067
86regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.80142993
87renal tubule development (GO:0061326)2.78989785
88triglyceride homeostasis (GO:0070328)2.78792365
89acylglycerol homeostasis (GO:0055090)2.78792365
90nucleobase catabolic process (GO:0046113)2.78663670
91regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.74411281
92regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.74411281
93positive regulation of vascular permeability (GO:0043117)2.73774886
94positive regulation of sodium ion transport (GO:0010765)2.71847974
95axoneme assembly (GO:0035082)2.70638397
96axonal fasciculation (GO:0007413)2.69759286
97regulation of acrosome reaction (GO:0060046)2.68417862
98olfactory bulb development (GO:0021772)2.66559144
99labyrinthine layer development (GO:0060711)2.65035384
100vitamin biosynthetic process (GO:0009110)2.63262382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.16084509
2EZH2_22144423_ChIP-Seq_EOC_Human4.14995905
3TAF15_26573619_Chip-Seq_HEK293_Human3.51182717
4ZNF274_21170338_ChIP-Seq_K562_Hela2.69916342
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.57797627
6GBX2_23144817_ChIP-Seq_PC3_Human2.42959859
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16788585
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13516609
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01124243
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00035523
11ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95610947
12SMAD4_21799915_ChIP-Seq_A2780_Human1.91640363
13PIAS1_25552417_ChIP-Seq_VCAP_Human1.91080277
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84854579
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81928866
16FUS_26573619_Chip-Seq_HEK293_Human1.81204698
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72555012
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.71255556
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70496411
20ARNT_22903824_ChIP-Seq_MCF-7_Human1.70293180
21NR3C1_23031785_ChIP-Seq_PC12_Mouse1.64697338
22BCAT_22108803_ChIP-Seq_LS180_Human1.63718734
23REST_21632747_ChIP-Seq_MESCs_Mouse1.60605476
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58858786
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49893294
26VDR_22108803_ChIP-Seq_LS180_Human1.49274943
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47579734
28AR_25329375_ChIP-Seq_VCAP_Human1.47096546
29TP53_16413492_ChIP-PET_HCT116_Human1.47001687
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46996999
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46720594
32CBP_20019798_ChIP-Seq_JUKART_Human1.46476049
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46476049
34VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.41800018
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40081889
36TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39579203
37STAT3_23295773_ChIP-Seq_U87_Human1.39208478
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38856227
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38690233
40TCF4_23295773_ChIP-Seq_U87_Human1.38221489
41TBL1_22424771_ChIP-Seq_293T_Human1.37837743
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30428971
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.29095762
44NFYA_21822215_ChIP-Seq_K562_Human1.28357932
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28149919
46AHR_22903824_ChIP-Seq_MCF-7_Human1.27326624
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25959387
48NFYB_21822215_ChIP-Seq_K562_Human1.23626475
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21726058
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21446469
51FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20195445
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.19666357
53CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18335157
54TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18265277
55KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18218023
56DROSHA_22980978_ChIP-Seq_HELA_Human1.17733755
57SOX2_18555785_Chip-Seq_ESCs_Mouse1.15380934
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15357009
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15026468
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.14814684
61TCF4_22108803_ChIP-Seq_LS180_Human1.14686516
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14128009
63PHF8_20622853_ChIP-Seq_HELA_Human1.13988027
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13822753
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12909293
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.12375407
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12340350
68EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11493445
69P300_19829295_ChIP-Seq_ESCs_Human1.11129474
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09979795
71P300_18555785_Chip-Seq_ESCs_Mouse1.09839282
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.09666163
73MYC_19829295_ChIP-Seq_ESCs_Human1.09399457
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.08219900
75GATA1_22025678_ChIP-Seq_K562_Human1.07934149
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07765890
77NMYC_18555785_Chip-Seq_ESCs_Mouse1.06369749
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06085362
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05512752
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05436253
81CDX2_22108803_ChIP-Seq_LS180_Human1.04848938
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04840368
83SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03821113
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.03608330
85HNFA_21074721_ChIP-Seq_CACO-2_Human1.03374022
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03308997
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03282151
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02978095
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02842608
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01952811
91RUNX2_22187159_ChIP-Seq_PCA_Human1.01683412
92SMAD3_21741376_ChIP-Seq_ESCs_Human1.01250737
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.01114017
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01043620
95GATA3_21878914_ChIP-Seq_MCF-7_Human1.00358574
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.00153287
97WDR5_24793694_ChIP-Seq_LNCAP_Human1.00086172
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.99961049
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99717434
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99600028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex5.94166790
2MP0001502_abnormal_circadian_rhythm3.40094714
3MP0003122_maternal_imprinting3.26794901
4MP0006276_abnormal_autonomic_nervous3.26163294
5MP0003121_genomic_imprinting3.25612133
6MP0003787_abnormal_imprinting3.13980953
7MP0009046_muscle_twitch3.06409305
8MP0002736_abnormal_nociception_after3.05995317
9MP0001968_abnormal_touch/_nociception2.62562569
10MP0001440_abnormal_grooming_behavior2.57299044
11MP0004859_abnormal_synaptic_plasticity2.55439707
12MP0002735_abnormal_chemical_nociception2.46809109
13MP0009780_abnormal_chondrocyte_physiolo2.45710600
14MP0005499_abnormal_olfactory_system2.23648716
15MP0005394_taste/olfaction_phenotype2.23648716
16MP0001984_abnormal_olfaction2.21302346
17MP0002909_abnormal_adrenal_gland2.18349435
18MP0008877_abnormal_DNA_methylation2.11139572
19MP0002572_abnormal_emotion/affect_behav2.00358357
20MP0003123_paternal_imprinting1.81544751
21MP0000569_abnormal_digit_pigmentation1.79487778
22MP0001501_abnormal_sleep_pattern1.77598935
23MP0009745_abnormal_behavioral_response1.76861481
24MP0002693_abnormal_pancreas_physiology1.74639977
25MP0003635_abnormal_synaptic_transmissio1.69364776
26MP0008789_abnormal_olfactory_epithelium1.68228493
27MP0002733_abnormal_thermal_nociception1.63864889
28MP0000778_abnormal_nervous_system1.63477197
29MP0000566_synostosis1.61318639
30MP0003879_abnormal_hair_cell1.60336533
31MP0001905_abnormal_dopamine_level1.59794946
32MP0005423_abnormal_somatic_nervous1.59189493
33MP0002557_abnormal_social/conspecific_i1.56903613
34MP0002272_abnormal_nervous_system1.55152318
35MP0003195_calcinosis1.53312055
36MP0002063_abnormal_learning/memory/cond1.51631518
37MP0005248_abnormal_Harderian_gland1.50730383
38MP0001970_abnormal_pain_threshold1.47010062
39MP0006072_abnormal_retinal_apoptosis1.46658255
40MP0002163_abnormal_gland_morphology1.40820637
41MP0005551_abnormal_eye_electrophysiolog1.36384423
42MP0005386_behavior/neurological_phenoty1.36295934
43MP0004924_abnormal_behavior1.36295934
44MP0002064_seizures1.35684807
45MP0005645_abnormal_hypothalamus_physiol1.31603290
46MP0000579_abnormal_nail_morphology1.30251192
47MP0000427_abnormal_hair_cycle1.28415886
48MP0005253_abnormal_eye_physiology1.26422060
49MP0004085_abnormal_heartbeat1.25038071
50MP0001485_abnormal_pinna_reflex1.23859701
51MP0002734_abnormal_mechanical_nocicepti1.21849326
52MP0005408_hypopigmentation1.17819770
53MP0003137_abnormal_impulse_conducting1.16392500
54MP0003646_muscle_fatigue1.16177315
55MP0003183_abnormal_peptide_metabolism1.15498340
56MP0002184_abnormal_innervation1.15436347
57MP0000230_abnormal_systemic_arterial1.14704118
58MP0002876_abnormal_thyroid_physiology1.13674760
59MP0003633_abnormal_nervous_system1.10002307
60MP0001346_abnormal_lacrimal_gland1.09848998
61MP0006292_abnormal_olfactory_placode1.09842133
62MP0001486_abnormal_startle_reflex1.05206961
63MP0003950_abnormal_plasma_membrane1.00008699
64MP0003890_abnormal_embryonic-extraembry0.98160934
65MP0003631_nervous_system_phenotype0.97404006
66MP0008995_early_reproductive_senescence0.96303670
67MP0005535_abnormal_body_temperature0.93741674
68MP0005595_abnormal_vascular_smooth0.93042204
69MP0001348_abnormal_lacrimal_gland0.90310627
70MP0002938_white_spotting0.89300284
71MP0002168_other_aberrant_phenotype0.88047506
72MP0010386_abnormal_urinary_bladder0.88020938
73MP0004133_heterotaxia0.87665123
74MP0005195_abnormal_posterior_eye0.86412888
75MP0001919_abnormal_reproductive_system0.84327443
76MP0002229_neurodegeneration0.83813931
77MP0004811_abnormal_neuron_physiology0.83780598
78MP0009703_decreased_birth_body0.80053619
79MP0008875_abnormal_xenobiotic_pharmacok0.79854828
80MP0005379_endocrine/exocrine_gland_phen0.78153992
81MP0002067_abnormal_sensory_capabilities0.76314142
82MP0000631_abnormal_neuroendocrine_gland0.76190865
83MP0002882_abnormal_neuron_morphology0.75942234
84MP0000383_abnormal_hair_follicle0.75636700
85MP0002971_abnormal_brown_adipose0.74804569
86MP0004145_abnormal_muscle_electrophysio0.74056915
87MP0004885_abnormal_endolymph0.71896655
88MP0002078_abnormal_glucose_homeostasis0.71891060
89MP0005365_abnormal_bile_salt0.71358436
90MP0005389_reproductive_system_phenotype0.68950790
91MP0010329_abnormal_lipoprotein_level0.68422727
92MP0001324_abnormal_eye_pigmentation0.67920314
93MP0004147_increased_porphyrin_level0.67244272
94MP0000372_irregular_coat_pigmentation0.67106541
95MP0003632_abnormal_nervous_system0.66094126
96MP0003953_abnormal_hormone_level0.65931077
97MP0004233_abnormal_muscle_weight0.64502459
98MP0004742_abnormal_vestibular_system0.63625863
99MP0001986_abnormal_taste_sensitivity0.62423713
100MP0002066_abnormal_motor_capabilities/c0.62370279

Predicted human phenotypes

RankGene SetZ-score
1Limb dystonia (HP:0002451)6.45340104
2Diastasis recti (HP:0001540)5.82560704
3Hyperventilation (HP:0002883)5.66296215
4Distal arthrogryposis (HP:0005684)4.86587172
5Mesangial abnormality (HP:0001966)4.82026049
6Abnormal rod and cone electroretinograms (HP:0008323)4.19753554
7Difficulty running (HP:0009046)4.17756539
8Hip dysplasia (HP:0001385)3.65572017
9Rib fusion (HP:0000902)3.56464721
10Microretrognathia (HP:0000308)3.29022989
11Abnormality of the labia minora (HP:0012880)3.21889886
12Molar tooth sign on MRI (HP:0002419)3.19466919
13Abnormality of midbrain morphology (HP:0002418)3.19466919
14Abnormal pupillary function (HP:0007686)3.17434327
15Pancreatic fibrosis (HP:0100732)3.13508654
16Cerebral hypomyelination (HP:0006808)3.03555556
17Exotropia (HP:0000577)3.02621688
18Protruding ear (HP:0000411)3.02578965
19Limb hypertonia (HP:0002509)3.01312851
20Hypothermia (HP:0002045)2.94084304
21Polyphagia (HP:0002591)2.93308333
22Left ventricular hypertrophy (HP:0001712)2.92634798
23Gait imbalance (HP:0002141)2.89181648
24Abnormal biliary tract physiology (HP:0012439)2.87453040
25Bile duct proliferation (HP:0001408)2.87453040
26Lissencephaly (HP:0001339)2.81491208
27Poor coordination (HP:0002370)2.80149292
28Nephronophthisis (HP:0000090)2.79801037
29Partial agenesis of the corpus callosum (HP:0001338)2.78303675
30Nephrogenic diabetes insipidus (HP:0009806)2.74051988
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.72624250
32Medial flaring of the eyebrow (HP:0010747)2.69020944
33Vertebral arch anomaly (HP:0008438)2.66928699
34Chronic hepatic failure (HP:0100626)2.65811854
35Natal tooth (HP:0000695)2.65257421
36Congenital primary aphakia (HP:0007707)2.63164269
37Volvulus (HP:0002580)2.63072000
38Protruding tongue (HP:0010808)2.62467685
39Nasal speech (HP:0001611)2.52995017
40Long foot (HP:0001833)2.52369721
41Macroorchidism (HP:0000053)2.52192454
42Thin upper lip vermilion (HP:0000219)2.48913324
43Narrow forehead (HP:0000341)2.46119215
44Thoracic kyphosis (HP:0002942)2.40959092
45Overlapping toe (HP:0001845)2.40217386
46Infantile muscular hypotonia (HP:0008947)2.38097910
47Tracheomalacia (HP:0002779)2.35844297
48Large eyes (HP:0001090)2.32444388
49Sleep apnea (HP:0010535)2.31048872
50Genital tract atresia (HP:0001827)2.31030460
51Decreased circulating renin level (HP:0003351)2.27850619
52Abnormality of the aortic arch (HP:0012303)2.26805411
53EEG with generalized epileptiform discharges (HP:0011198)2.26536300
54Hypsarrhythmia (HP:0002521)2.25217748
55Abnormality of the renal medulla (HP:0100957)2.23253973
56Pachygyria (HP:0001302)2.20439245
57Agitation (HP:0000713)2.18224099
58Symphalangism affecting the phalanges of the hand (HP:0009773)2.17442560
59Epileptiform EEG discharges (HP:0011182)2.17280753
60Bony spicule pigmentary retinopathy (HP:0007737)2.17270822
61Abolished electroretinogram (ERG) (HP:0000550)2.14205953
62Metabolic alkalosis (HP:0200114)2.13813767
63Fetal akinesia sequence (HP:0001989)2.13461786
64True hermaphroditism (HP:0010459)2.10698971
65Highly arched eyebrow (HP:0002553)2.04317659
66Nephrotic syndrome (HP:0000100)2.02989812
67Personality changes (HP:0000751)2.01511643
68Vaginal atresia (HP:0000148)1.99157177
69Prominent nasal bridge (HP:0000426)1.99030542
70Unsteady gait (HP:0002317)1.97021488
71Abnormal drinking behavior (HP:0030082)1.94159235
72Polydipsia (HP:0001959)1.94159235
73Abnormal number of incisors (HP:0011064)1.94122650
74Pancreatic cysts (HP:0001737)1.93867401
75Esotropia (HP:0000565)1.93757743
76Primary atrial arrhythmia (HP:0001692)1.92045136
77Upper limb muscle weakness (HP:0003484)1.89300063
78Oligodontia (HP:0000677)1.88093984
79Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.88041843
80Decreased testicular size (HP:0008734)1.87688606
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.86760171
82Hypoplastic nipples (HP:0002557)1.86393291
83Asymmetry of the thorax (HP:0001555)1.85589830
84Type II lissencephaly (HP:0007260)1.81824815
85Epileptic encephalopathy (HP:0200134)1.81259832
86Cone-rod dystrophy (HP:0000548)1.80600314
87Abnormality of the musculature of the hand (HP:0001421)1.79507095
88Fragile skin (HP:0001030)1.78502899
89Tubular atrophy (HP:0000092)1.77370190
90Specific learning disability (HP:0001328)1.77129269
91Supraventricular tachycardia (HP:0004755)1.75856041
92Vitreoretinal degeneration (HP:0000655)1.73844661
93Cystic liver disease (HP:0006706)1.73391637
94Bifid tongue (HP:0010297)1.72417602
95Abnormality of the renal cortex (HP:0011035)1.71146917
96Postaxial hand polydactyly (HP:0001162)1.70893846
97Dyschromatopsia (HP:0007641)1.70000628
98Papilledema (HP:0001085)1.69869221
99Aplasia/Hypoplasia of the lens (HP:0008063)1.69847563
100Atrial fibrillation (HP:0005110)1.69649092

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K95.75436457
2WNK34.08366910
3PIK3CG3.52248928
4IRAK43.24375769
5CASK2.51040997
6SGK22.44217913
7PINK12.41619263
8PDK22.41234755
9CSNK1G32.39482957
10ACVR1B2.34955688
11CSNK1G12.28535369
12FRK2.22213495
13SGK32.03800249
14CAMK1D2.03461101
15CDK122.00343086
16CSNK1G21.88413253
17SGK2231.86788571
18SGK4941.86788571
19CAMK1G1.82813679
20PRKCH1.79724799
21MAP3K41.76676925
22PAK31.76421655
23MAPK131.74087725
24FGFR21.71248615
25MKNK21.66020518
26PRKD31.63246379
27ERN11.54223734
28PHKG21.34901827
29PHKG11.34901827
30TNIK1.28322896
31MAP3K121.28286209
32ADRBK21.28002441
33RPS6KA21.19684161
34CSNK1E1.18389029
35GRK11.10786935
36MAP2K71.05938369
37MINK11.05159566
38TLK11.02048313
39ALK1.01749985
40BMPR1B0.95598356
41MARK10.89377190
42NTRK30.88224536
43PNCK0.84785290
44UHMK10.81227131
45CAMK10.80353309
46PRKCG0.78372318
47RPS6KB10.78130633
48TAOK30.76204387
49PRKCZ0.75361894
50MAP3K20.73539979
51PRKAA10.72790681
52NTRK20.70393678
53PRKCE0.70043694
54MARK30.67681640
55RPS6KA60.67369085
56KIT0.65854434
57DMPK0.61466877
58SGK10.60703232
59WNK40.59520490
60RPS6KC10.56776656
61RPS6KL10.56776656
62OXSR10.55500560
63DAPK20.55009269
64PAK60.54603921
65PIK3CA0.54102087
66CAMKK10.53601796
67FER0.52101624
68MAP2K10.51284036
69PRKD20.51012438
70TXK0.49123765
71MKNK10.49092374
72PKN10.48953661
73EPHA30.46538945
74ERBB30.45818275
75CSNK1A10.45053465
76DYRK20.44436802
77GSK3A0.43967468
78STK110.43233601
79PRKAA20.42102339
80PRKCI0.40992950
81BRSK10.38933245
82CDK50.38622977
83MAPK10.37476497
84ADRBK10.37251576
85MST40.37039077
86PRKCA0.36183314
87CSNK2A20.35198430
88PRKACA0.35088552
89OBSCN0.35087950
90CSNK1D0.32801098
91CAMKK20.30855685
92NUAK10.29720598
93MAP2K40.28647562
94TYRO30.28564045
95PAK40.27560091
96CAMK2D0.27327296
97CAMK2G0.26165866
98MARK20.25743475
99MYLK0.24568115
100DYRK1A0.24073818

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001305.74803397
2Nitrogen metabolism_Homo sapiens_hsa009103.72657990
3Cocaine addiction_Homo sapiens_hsa050303.15196559
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.07861384
5Circadian rhythm_Homo sapiens_hsa047102.97268581
6Amphetamine addiction_Homo sapiens_hsa050312.64588394
7Nicotine addiction_Homo sapiens_hsa050332.61632028
8Linoleic acid metabolism_Homo sapiens_hsa005912.19968789
9Synaptic vesicle cycle_Homo sapiens_hsa047212.18736382
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07172635
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94868990
12Selenocompound metabolism_Homo sapiens_hsa004501.90649114
13Ovarian steroidogenesis_Homo sapiens_hsa049131.89476571
14Insulin secretion_Homo sapiens_hsa049111.79131433
15Ether lipid metabolism_Homo sapiens_hsa005651.78383732
16Dopaminergic synapse_Homo sapiens_hsa047281.77350710
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.61331331
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.53200908
19Circadian entrainment_Homo sapiens_hsa047131.48420587
20Fatty acid biosynthesis_Homo sapiens_hsa000611.48142091
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43800125
22Glutamatergic synapse_Homo sapiens_hsa047241.36632102
23Pancreatic secretion_Homo sapiens_hsa049721.32032263
24Butanoate metabolism_Homo sapiens_hsa006501.28902630
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27201454
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26880522
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25142473
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.21061988
29Serotonergic synapse_Homo sapiens_hsa047261.17194239
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.17085465
31Steroid biosynthesis_Homo sapiens_hsa001001.16107988
32Cardiac muscle contraction_Homo sapiens_hsa042601.11518847
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05843649
34One carbon pool by folate_Homo sapiens_hsa006701.02728545
35Phenylalanine metabolism_Homo sapiens_hsa003601.00359846
36Taste transduction_Homo sapiens_hsa047420.97914123
37Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95236444
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94074407
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92778600
40Collecting duct acid secretion_Homo sapiens_hsa049660.91712757
41Caffeine metabolism_Homo sapiens_hsa002320.91365175
42Histidine metabolism_Homo sapiens_hsa003400.91189975
43Long-term depression_Homo sapiens_hsa047300.88607460
44cAMP signaling pathway_Homo sapiens_hsa040240.85517628
45Basal transcription factors_Homo sapiens_hsa030220.85477092
46GABAergic synapse_Homo sapiens_hsa047270.84600948
47Glycerolipid metabolism_Homo sapiens_hsa005610.83585777
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81404733
49Dorso-ventral axis formation_Homo sapiens_hsa043200.77738167
50Salivary secretion_Homo sapiens_hsa049700.77563463
51Morphine addiction_Homo sapiens_hsa050320.75008805
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.74430370
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71069449
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.70678589
55Bile secretion_Homo sapiens_hsa049760.70574982
56Mineral absorption_Homo sapiens_hsa049780.70457098
57Phototransduction_Homo sapiens_hsa047440.70400286
58Olfactory transduction_Homo sapiens_hsa047400.69177331
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69008538
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68892952
61Tryptophan metabolism_Homo sapiens_hsa003800.62954274
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61670266
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60969880
64Gastric acid secretion_Homo sapiens_hsa049710.59477932
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59438253
66Renin secretion_Homo sapiens_hsa049240.59210303
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59182956
68Sulfur metabolism_Homo sapiens_hsa009200.58828140
69Dilated cardiomyopathy_Homo sapiens_hsa054140.57381388
70Thyroid hormone synthesis_Homo sapiens_hsa049180.57163737
71Arginine biosynthesis_Homo sapiens_hsa002200.55926814
72Fatty acid degradation_Homo sapiens_hsa000710.55162500
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55048019
74Chemical carcinogenesis_Homo sapiens_hsa052040.52242709
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.52087024
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51718631
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51331240
78Cholinergic synapse_Homo sapiens_hsa047250.51091946
79Parkinsons disease_Homo sapiens_hsa050120.50014236
80Type II diabetes mellitus_Homo sapiens_hsa049300.49718746
81Oxidative phosphorylation_Homo sapiens_hsa001900.46035791
82Metabolic pathways_Homo sapiens_hsa011000.44473005
83Peroxisome_Homo sapiens_hsa041460.42147878
84Glucagon signaling pathway_Homo sapiens_hsa049220.42133918
85Retinol metabolism_Homo sapiens_hsa008300.41800399
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41014614
87Arachidonic acid metabolism_Homo sapiens_hsa005900.40907279
88MAPK signaling pathway_Homo sapiens_hsa040100.38377951
89Calcium signaling pathway_Homo sapiens_hsa040200.37521734
90Oxytocin signaling pathway_Homo sapiens_hsa049210.37380108
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35539316
92Arginine and proline metabolism_Homo sapiens_hsa003300.34731126
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34569310
94Fat digestion and absorption_Homo sapiens_hsa049750.34416611
95Axon guidance_Homo sapiens_hsa043600.33336273
96Huntingtons disease_Homo sapiens_hsa050160.32910828
97beta-Alanine metabolism_Homo sapiens_hsa004100.32786629
98Lysine degradation_Homo sapiens_hsa003100.27872138
99Alcoholism_Homo sapiens_hsa050340.26748612
100Fatty acid metabolism_Homo sapiens_hsa012120.24819484

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